Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CDK18 MARK2 PIK3CA PLK4 BRD4 AURKB	1.81e-04	446	38	6	GO:0004674
GeneOntologyMolecularFunction	insulin receptor substrate binding	ZNF592 PIK3CA	3.65e-04	15	38	2	GO:0043560
GeneOntologyMolecularFunction	protein serine kinase activity	CDK18 MARK2 PIK3CA PLK4 AURKB	5.92e-04	363	38	5	GO:0106310
Domain	DUF1669	FAM83G FAM83C	1.18e-04	8	39	2	IPR012461
Domain	DUF1669	FAM83G FAM83C	1.18e-04	8	39	2	PF07894
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	MARK2 PLK4 AURKB	4.01e-04	69	39	3	IPR020636
Domain	Ank_2	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.02e-03	215	39	4	PF12796
Domain	Ank	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.27e-03	228	39	4	PF00023
Domain	-	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.73e-03	248	39	4	1.25.40.20
Domain	ANK	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.81e-03	251	39	4	SM00248
Domain	ANK_REPEAT	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.86e-03	253	39	4	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.89e-03	254	39	4	IPR020683
Domain	ANK_REP_REGION	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.89e-03	254	39	4	PS50297
Domain	Ankyrin_rpt	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	2.12e-03	262	39	4	IPR002110
Domain	C2	CPNE4 PIK3CA CADPS	2.91e-03	137	39	3	SM00239
Domain	C2	CPNE4 PIK3CA CADPS	3.22e-03	142	39	3	PS50004
Domain	C2_dom	CPNE4 PIK3CA CADPS	4.82e-03	164	39	3	IPR000008
Domain	Kinase-like_dom	CDK18 MARK2 PIK3CA PLK4 AURKB	5.15e-03	542	39	5	IPR011009
Domain	S_TKc	CDK18 MARK2 PLK4 AURKB	6.50e-03	359	39	4	SM00220
Domain	PROTEIN_KINASE_ST	CDK18 MARK2 PLK4 AURKB	6.69e-03	362	39	4	PS00108
Domain	Protein_kinase_ATP_BS	CDK18 MARK2 PLK4 AURKB	7.84e-03	379	39	4	IPR017441
Domain	Pkinase	CDK18 MARK2 PLK4 AURKB	7.98e-03	381	39	4	PF00069
Pubmed	Expression of testicular germ cell genes identified by differential display analysis.	ANKRD20A3P ANKRD20A4P ANKRD20A1	7.27e-08	8	39	3	12634303
Pubmed	Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.	PIK3CA BRD4	1.23e-06	2	39	2	29133261
Pubmed	Regulation of aurora B expression by the bromodomain protein Brd4.	BRD4 AURKB	1.23e-06	2	39	2	19596781
Pubmed	TGF-β induces PML SUMOylation, degradation and PML nuclear body disruption.	CASP8 PML	3.67e-06	3	39	2	31153006
Pubmed	BRD4 interacts with PML/RARα in acute promyelocytic leukemia.	BRD4 PML	3.67e-06	3	39	2	30552662
Pubmed	Absence of the frequently reported PIK3CA, CASP8, and NOTCH1 mutations in South Indian oral cancers.	CASP8 PIK3CA	3.67e-06	3	39	2	28181739
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FAM83G CDK18 MARK2 NELFCD VIRMA PLK4 BRD4 PML	4.26e-06	861	39	8	36931259
Pubmed	Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.	CASP8 PIK3CA	1.22e-05	5	39	2	20379197
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PYGB XPA ZNF592 NELFCD VIRMA BRD4 PML AURKB	1.40e-05	1014	39	8	32416067
Pubmed	PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.	CASP8 PML	3.42e-05	8	39	2	21803845
Pubmed	Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.	UTP20 DNAH5	3.42e-05	8	39	2	17903303
Pubmed	The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.	FAM83G FAM83C	6.70e-05	11	39	2	29789297
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	CASP8 PIK3CA BRD4	7.07e-05	71	39	3	28319113
Pubmed	Pharmacogenetic analyses of hematotoxicity in advanced gastric cancer patients receiving biweekly fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).	XPA CYP3A4	1.27e-04	15	39	2	19074750
Pubmed	Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.	MARK2 PLK4	1.46e-04	16	39	2	8274451
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZBTB26 FANCM DNAH5	2.01e-04	101	39	3	10997877
Pubmed	Lost in transcription: molecular mechanisms that control HIV latency.	NELFCD BRD4	2.07e-04	19	39	2	23518577
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	PIK3CA PLK4 AURKB	2.07e-04	102	39	3	20508983
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UTP20 MARK2 ZNF592 OTUD5 VIRMA BRD4	2.08e-04	774	39	6	15302935
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	CDK18 PYGB UTP20 PML	2.10e-04	262	39	4	36880596
Pubmed	BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	CASP8 PIK3CA	2.54e-04	21	39	2	20301425
Pubmed	Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.	COPS3 NELFCD	3.05e-04	23	39	2	12620389
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	CASP8 PYGB ST3GAL5 PML	4.13e-04	313	39	4	20800603
Pubmed	Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.	FAM83G COPS3	5.23e-04	30	39	2	24292625
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	CASP8 XPA CYP3A4 PIK3CA	6.35e-04	351	39	4	20453000
Pubmed	alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.	XPA PML	6.72e-04	34	39	2	16889989
Pubmed	DNA sequence and analysis of human chromosome 9.	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	7.73e-04	370	39	4	15164053
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PYGB COPS3 MARK2 CPNE4 VIRMA CADPS METAP2	9.52e-04	1431	39	7	37142655
Pubmed	Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.	FANCM PML	9.77e-04	41	39	2	15561718
Pubmed	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	CASP8 PML AURKB	1.07e-03	179	39	3	19074885
Interaction	ANKRD20A4P interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	1.33e-07	6	39	3	int:ANKRD20A4P
Interaction	ANKRD20A2P interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	2.33e-07	7	39	3	int:ANKRD20A2P
Interaction	ANKRD20A1 interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	1.09e-06	11	39	3	int:ANKRD20A1
Interaction	CASP8AP2 interactions	CASP8 VIRMA BRD4 PML	3.03e-06	52	39	4	int:CASP8AP2
Interaction	RPS7 interactions	UTP20 COPS3 VIRMA METAP2 BRD4 PML AURKB	2.74e-05	466	39	7	int:RPS7
Interaction	MAMLD1 interactions	VIRMA PML	3.64e-05	5	39	2	int:MAMLD1
Interaction	GTF3C3 interactions	CPNE4 VIRMA BRD4 PML AURKB	5.53e-05	214	39	5	int:GTF3C3
Interaction	PPM1B interactions	FANCM VIRMA PLK4 BRD4 AURKB	5.78e-05	216	39	5	int:PPM1B
Interaction	ATR interactions	XPA VIRMA PIK3CA BRD4 PML	5.91e-05	217	39	5	int:ATR
Interaction	ZNF687 interactions	ZNF592 VIRMA BRD4 PML	7.09e-05	115	39	4	int:ZNF687
Interaction	NUP205 interactions	FBXL13 VIRMA BRD4 PML AURKB	8.61e-05	235	39	5	int:NUP205
Interaction	KLHL21 interactions	XPA VIRMA AURKB	9.60e-05	46	39	3	int:KLHL21
Interaction	LRRC37B interactions	VIRMA METAP2	1.01e-04	8	39	2	int:LRRC37B
Cytoband	9p12	ANKRD20A2P ANKRD20A3P	2.81e-04	29	39	2	9p12
GeneFamily	Ankyrin repeat domain containing	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	4.98e-04	242	28	4	403
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GRM7 AURKB	3.18e-02	181	28	2	694
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_200	NAP1L2 GRM7 CADPS	3.60e-05	35	39	3	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_200
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ST3GAL5 ANKRD20A1	5.57e-07	184	39	5	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	IPF-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ST3GAL5 ANKRD20A1	5.88e-07	186	39	5	962c2dada19185628ead77c32fcb07fa95114247
ToppCell	IPF-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ST3GAL5 ANKRD20A1	6.20e-07	188	39	5	47bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCell	IPF-Myeloid-cDC1\|IPF / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ST3GAL5 ANKRD20A1	6.20e-07	188	39	5	2331a2bae1383820d598e93aa86c75b101069bac
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ST3GAL5 ANKRD20A1	6.70e-07	191	39	5	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PYGB UTP20 COPS3 CPNE4	1.39e-05	168	39	4	d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.99e-05	184	39	4	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	Control-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	2.08e-05	186	39	4	3de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCell	Control-Myeloid-cDC1\|Control / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	2.08e-05	186	39	4	b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	2.35e-05	192	39	4	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	mLN-(5)_Dendritic_cell-(53)_Lymphoid_DC\|mLN / shred on region, Cell_type, and subtype	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	2.65e-05	198	39	4	da84c76afe835aeee39da04b63c03549218b5d91
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|mLN / Region, Cell class and subclass	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	2.65e-05	198	39	4	3965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
Drug	lonafarnib	CASP8 CYP3A4 PIK3CA METAP2 PML	2.19e-06	124	39	5	CID000148195
Drug	UCN-01	CASP8 CDK18 XPA METAP2 AURKB	6.34e-06	154	39	5	CID000072271
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A	CASP8 GGA2 ST3GAL5 PLK4 PML	1.89e-05	193	39	5	3624_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT_HG-U133A	UTP20 GGA2 CYP3A4 PLK4 PML	1.99e-05	195	39	5	1668_DN
Drug	Quinic acid [86-68-0]; Down 200; 19.6uM; PC3; HT_HG-U133A	XPA GGA2 ST3GAL5 BRD4 PML	2.04e-05	196	39	5	7317_DN
Drug	Succinylsulfathiazole [116-43-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	CASP8 GGA2 ST3GAL5 CYP3A4 PLK4	2.09e-05	197	39	5	4265_DN
Disease	Squamous cell carcinoma of mouth	CASP8 PIK3CA	1.36e-05	5	35	2	C0585362
Disease	HEPATOCELLULAR CARCINOMA	CASP8 PIK3CA	4.89e-05	9	35	2	114550
Disease	Adult Hepatocellular Carcinoma	CASP8 PIK3CA	4.89e-05	9	35	2	C0279607
Disease	Hepatocellular carcinoma	CASP8 PIK3CA	4.89e-05	9	35	2	cv:C2239176
Disease	Lung cancer	CASP8 PIK3CA	1.23e-04	14	35	2	cv:C0242379
Disease	LUNG CANCER	CASP8 PIK3CA	1.23e-04	14	35	2	211980
Disease	Neoplasm of lung	CASP8 PIK3CA	1.23e-04	14	35	2	cv:C0024121
Disease	Adenoid Cystic Carcinoma	PYGB MARK2 PIK3CA	2.28e-04	100	35	3	C0010606
Disease	BREAST CANCER	CASP8 PIK3CA	2.83e-04	21	35	2	114480
Disease	Headache, HbA1c measurement	CASP8 PML	2.83e-04	21	35	2	EFO_0004541, HP_0002315
Disease	Glioblastoma Multiforme	PIK3CA BRD4 PML	3.11e-04	111	35	3	C1621958
Disease	Malignant tumor of breast	CASP8 PIK3CA	4.71e-04	27	35	2	cv:C0006142
Disease	Breast neoplasm	CASP8 PIK3CA	4.71e-04	27	35	2	cv:C1458155
Disease	Familial cancer of breast	CASP8 PIK3CA	4.71e-04	27	35	2	cv:C0346153
Disease	Hyperplasia	PIK3CA BRD4	5.07e-04	28	35	2	C0020507
Disease	Pigmented Basal Cell Carcinoma	XPA PIK3CA	5.07e-04	28	35	2	C1368275
Disease	Strabismus	DNAH5 CADPS	5.44e-04	29	35	2	HP_0000486
Disease	Carcinoma, Basal Cell	XPA PIK3CA	5.44e-04	29	35	2	C4721806
Disease	colorectal adenoma	FBXL13 GRM7	7.05e-04	33	35	2	EFO_0005406
Disease	Breast adenocarcinoma	CASP8 PIK3CA	1.09e-03	41	35	2	C0858252
Disease	Cutaneous Melanoma	XPA PIK3CA	1.09e-03	41	35	2	C0151779
Disease	Neoplasm of uncertain or unknown behavior of breast	CASP8 PIK3CA	1.09e-03	41	35	2	C0496956

Protein segments in the cluster

Peptide	Gene	Start	Entry
FHNHEEMKGLMDENC	ANKRD20A1	501	Q5TYW2
MMDICKENGAYDAKH	COPS3	166	Q9UNS2
GLHDYCDIIKHPMDM	BRD4	386	O60885
LKQYLDHCGNLMSMH	CDK18	226	Q07002
FHNHEEMKGLMDENC	ANKRD20A4P	501	Q4UJ75
CHEEMYGNEEGMVHE	NAP1L2	181	Q9ULW6
FHNHEEMKGLMDENC	ANKRD20A2P	501	Q5SQ80
LCSMEMGQEHQYHSK	CADPS	1151	Q9ULU8
DMDKALLYFIHVMDH	GDAP2	366	Q9NXN4
KGVVHDDMECSHYMK	METAP2	371	P50579
DDMECSHYMKNFDVG	METAP2	376	P50579
VCHGEHTYLFAQAMM	NELFCD	231	Q8IXH7
NEDFMKLYNHLECMF	FANCM	406	Q8IYD8
LSYHKGFCMFDMECH	CYP3A4	51	P08684
LEMCMNHCGEKFHSE	GGA2	86	Q9UJY4
LEYFMKQMNDAHHGG	PIK3CA	1036	P42336
FHNHEEMKGLMDENC	ANKRD20A3P	501	Q5VUR7
QEHLRHFLEMCYKMD	FAM83C	206	Q9BQN1
HFLEMCYKMDLNGEH	FAM83C	211	Q9BQN1
HKMHSFLDYIMGGCQ	CPNE4	291	Q96A23
DSAMEMLSAKCHYLH	FBXL13	621	Q8NEE6
LKIYQLMDHSNMDCF	CASP8	296	Q14790
ELHEKYMLLCMHGTP	MARK2	726	Q7KZI7
YAMAHALHHMNKDLC	GRM7	416	Q14831
KMTDELYHHMPENRC	ERMARD	481	Q5T6L9
DDLCHMHIKSPMDFE	DNAH5	1901	Q8TE73
DQDMHEVVRKHCMDY	OTUD5	236	Q96G74
NVKYFLHMCERACMH	FAM83G	211	A6ND36
HYHDPEMDFFENMKH	UTP20	1566	O75691
TMAKEEACHGLMQEY	RGSL1	201	A5PLK6
MKCYASDQEVLDMHG	PML	336	P29590
ECDMKKMHYVDPDHV	ST3GAL5	91	Q9UNP4
KMYMDHANEGHRICL	PLK4	766	O00444
GKMHPTFCENKHYLM	CLEC1B	201	Q9P126
MEELADALMYCHGKK	AURKB	181	Q96GD4
CHKQMRDYMVLAAHF	ZNF592	716	Q92610
PDCFKDIVNMLMHHD	PYGB	756	P11216
EECGKEFMDSYLMNH	XPA	106	P23025
MMFLAEHDYGLFHLK	VIRMA	1351	Q69YN4
ENYANHLKMHKLFMC	ZBTB26	286	Q9HCK0
LFKHMCYEMERLHNG	NALCN	1511	Q8IZF0