Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM5 RYR3 ITPR3	1.32e-04	31	64	3	GO:0099604
GeneOntologyBiologicalProcess	protein complex oligomerization	TRPM7 ZNF746 PRMT1 RRM2 ZDHHC1 RYR3 ITPR3	3.25e-05	296	63	7	GO:0051259
GeneOntologyBiologicalProcess	negative regulation of smooth muscle contraction	NCF1 CALCRL NCF1B	4.01e-05	22	63	3	GO:0045986
Domain	DUF1088	NBEA LRBA	1.12e-05	2	63	2	IPR010508
Domain	DUF1088	NBEA LRBA	1.12e-05	2	63	2	PF06469
Domain	HSA	SMARCA2 SRCAP	6.69e-05	4	63	2	SM00573
Domain	HSA	SMARCA2 SRCAP	6.69e-05	4	63	2	PS51204
Domain	HSA_dom	SMARCA2 SRCAP	6.69e-05	4	63	2	IPR014012
Domain	HSA	SMARCA2 SRCAP	6.69e-05	4	63	2	PF07529
Domain	ConA-like_dom	PAPPA2 RNF123 NBEA LRBA TRIM22 RYR3	9.45e-05	219	63	6	IPR013320
Domain	DUF4704	NBEA LRBA	1.11e-04	5	63	2	IPR031570
Domain	DUF4704	NBEA LRBA	1.11e-04	5	63	2	PF15787
Domain	ARM-type_fold	DOCK1 IFT172 MROH2A ASPM NBEA LRBA RYR3	1.41e-04	339	63	7	IPR016024
Domain	RIH_assoc	RYR3 ITPR3	1.67e-04	6	63	2	PF08454
Domain	RIH_assoc-dom	RYR3 ITPR3	1.67e-04	6	63	2	IPR013662
Domain	RIH_dom	RYR3 ITPR3	1.67e-04	6	63	2	IPR000699
Domain	Ins145_P3_rcpt	RYR3 ITPR3	1.67e-04	6	63	2	IPR014821
Domain	Ryanodine_recept-rel	RYR3 ITPR3	1.67e-04	6	63	2	IPR015925
Domain	PH_BEACH	NBEA LRBA	1.67e-04	6	63	2	PF14844
Domain	-	RYR3 ITPR3	1.67e-04	6	63	2	1.25.10.30
Domain	RYDR_ITPR	RYR3 ITPR3	1.67e-04	6	63	2	PF01365
Domain	Ins145_P3_rec	RYR3 ITPR3	1.67e-04	6	63	2	PF08709
Domain	PH-BEACH_dom	NBEA LRBA	3.09e-04	8	63	2	IPR023362
Domain	-	NBEA LRBA	3.09e-04	8	63	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	3.09e-04	8	63	2	PS51783
Domain	BEACH_dom	NBEA LRBA	3.97e-04	9	63	2	IPR000409
Domain	BEACH	NBEA LRBA	3.97e-04	9	63	2	PS50197
Domain	Beach	NBEA LRBA	3.97e-04	9	63	2	PF02138
Domain	-	NBEA LRBA	3.97e-04	9	63	2	1.10.1540.10
Domain	Beach	NBEA LRBA	3.97e-04	9	63	2	SM01026
Domain	MIR	RYR3 ITPR3	4.95e-04	10	63	2	PS50919
Domain	MIR	RYR3 ITPR3	4.95e-04	10	63	2	PF02815
Domain	MIR	RYR3 ITPR3	4.95e-04	10	63	2	SM00472
Domain	MIR_motif	RYR3 ITPR3	4.95e-04	10	63	2	IPR016093
Domain	Ion_trans_dom	TRPM5 TRPM7 RYR3 ITPR3	5.94e-04	114	63	4	IPR005821
Domain	Ion_trans	TRPM5 TRPM7 RYR3 ITPR3	5.94e-04	114	63	4	PF00520
Domain	Dynein_heavy_chain_D4_dom	DNAH7 DNAH11	9.93e-04	14	63	2	IPR024317
Domain	Dynein_HC_stalk	DNAH7 DNAH11	9.93e-04	14	63	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH7 DNAH11	9.93e-04	14	63	2	IPR013602
Domain	DHC_N2	DNAH7 DNAH11	9.93e-04	14	63	2	PF08393
Domain	MT	DNAH7 DNAH11	9.93e-04	14	63	2	PF12777
Domain	AAA_8	DNAH7 DNAH11	9.93e-04	14	63	2	PF12780
Domain	DHC_fam	DNAH7 DNAH11	1.14e-03	15	63	2	IPR026983
Domain	Dynein_heavy_dom	DNAH7 DNAH11	1.14e-03	15	63	2	IPR004273
Domain	Dynein_heavy	DNAH7 DNAH11	1.14e-03	15	63	2	PF03028
Domain	zf-DHHC	ZDHHC1 ZDHHC4	2.71e-03	23	63	2	PF01529
Domain	SPRY	RNF123 TRIM22 RYR3	3.17e-03	87	63	3	SM00449
Domain	DHHC	ZDHHC1 ZDHHC4	3.20e-03	25	63	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC1 ZDHHC4	3.20e-03	25	63	2	IPR001594
Domain	WD40_repeat_dom	FBXW8 ITFG2 IFT172 NBEA LRBA	3.26e-03	297	63	5	IPR017986
Domain	FN3	PAPPA2 IL12RB2 EPHA2 CNTN1	3.52e-03	185	63	4	SM00060
Domain	SPRY	RNF123 TRIM22 RYR3	3.94e-03	94	63	3	PF00622
Domain	SPRY_dom	RNF123 TRIM22 RYR3	3.94e-03	94	63	3	IPR003877
Domain	B30.2/SPRY	RNF123 TRIM22 RYR3	4.06e-03	95	63	3	IPR001870
Domain	B302_SPRY	RNF123 TRIM22 RYR3	4.06e-03	95	63	3	PS50188
Domain	-	PAPPA2 NBEA LRBA	4.06e-03	95	63	3	2.60.120.200
Domain	SNF2_N	SMARCA2 SRCAP	5.20e-03	32	63	2	IPR000330
Domain	SNF2_N	SMARCA2 SRCAP	5.20e-03	32	63	2	PF00176
Domain	FN3_dom	PAPPA2 IL12RB2 EPHA2 CNTN1	5.42e-03	209	63	4	IPR003961
Pathway	REACTOME_RAC2_GTPASE_CYCLE	DOCK1 EPHA2 NCF1 ARHGAP35 NCF1B	1.65e-05	87	52	5	MM15600
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPM5 CLCN5 TRPM7 SCNN1G RYR3	3.09e-05	99	52	5	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPM5 CLCN5 TRPM7 SCNN1G RYR3	4.29e-05	106	52	5	M27200
Pathway	REACTOME_RAC2_GTPASE_CYCLE	DOCK1 EPHA2 NCF1 ARHGAP35	3.05e-04	88	52	4	M41810
Pathway	REACTOME_RAC3_GTPASE_CYCLE	EPHA2 NCF1 ARHGAP35 NCF1B	3.77e-04	93	52	4	MM15609
Pathway	REACTOME_RAC1_GTPASE_CYCLE	DOCK1 EPHA2 NCF1 ARHGAP35 NCF1B	4.51e-04	175	52	5	MM15599
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM5 CLCN5 TRPM7 SCNN1G RYR3	4.63e-04	176	52	5	MM15718
Pathway	REACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES	NCF1 NCF1B	4.73e-04	9	52	2	MM14524
Pathway	REACTOME_RND3_GTPASE_CYCLE	PTPN13 EPHA2 ARHGAP35	4.91e-04	42	52	3	M41826
Pathway	REACTOME_RND1_GTPASE_CYCLE	PTPN13 EPHA2 ARHGAP35	4.91e-04	42	52	3	M41828
Pathway	REACTOME_RND3_GTPASE_CYCLE	PTPN13 EPHA2 ARHGAP35	4.91e-04	42	52	3	MM15677
Pathway	REACTOME_RND2_GTPASE_CYCLE	PTPN13 EPHA2 ARHGAP35	5.26e-04	43	52	3	M41827
Pathway	REACTOME_RND1_GTPASE_CYCLE	PTPN13 EPHA2 ARHGAP35	5.26e-04	43	52	3	MM15679
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM5 CLCN5 TRPM7 SCNN1G RYR3	5.53e-04	183	52	5	M997
Pathway	REACTOME_RND2_GTPASE_CYCLE	PTPN13 EPHA2 ARHGAP35	5.64e-04	44	52	3	MM15678
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	TRPM5 SCNN1G ITPR3	6.85e-04	47	52	3	M42524
Pathway	KEGG_TASTE_TRANSDUCTION	TRPM5 SCNN1G ITPR3	9.21e-04	52	52	3	M5785
Pathway	WP_MFAP5MEDIATED_OVARIAN_CANCER_CELL_MOTILITY_AND_INVASIVENESS	RYR3 ITPR3	1.01e-03	13	52	2	M39463
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	DOCK1 ARHGAP35	1.01e-03	13	52	2	MM15484
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	DOCK1 ARHGAP35	1.18e-03	14	52	2	M27734
Pubmed	[PRMT1 inhibits apoptosis of nasopharyngeal carcinoma cells by promoting RRM2 expression].	PRMT1 RRM2	3.44e-06	2	65	2	36651245
Pubmed	ClC-5 chloride channel alters expression of the epithelial sodium channel (ENaC).	CLCN5 SCNN1G	3.44e-06	2	65	2	15702377
Pubmed	Transcriptional specificity of the pluripotent embryonic stem cell.	EPHA2 PRMT1	3.44e-06	2	65	2	8891343
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1 NCF1B	1.03e-05	3	65	2	18036262
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1 NCF1B	1.03e-05	3	65	2	10678931
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1 NCF1B	1.03e-05	3	65	2	27044504
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1 NCF1B	1.03e-05	3	65	2	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1 NCF1B	1.03e-05	3	65	2	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1 NCF1B	1.03e-05	3	65	2	10891396
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1 NCF1B	1.03e-05	3	65	2	25474113
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1 NCF1B	1.03e-05	3	65	2	18787174
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1 NCF1B	1.03e-05	3	65	2	26209274
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1 NCF1B	1.03e-05	3	65	2	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1 NCF1B	1.03e-05	3	65	2	22184329
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1 NCF1B	1.03e-05	3	65	2	11018074
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1 NCF1B	1.03e-05	3	65	2	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1 NCF1B	1.03e-05	3	65	2	20142487
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	1.03e-05	3	65	2	28814779
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1 NCF1B	1.03e-05	3	65	2	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1 NCF1B	1.03e-05	3	65	2	20686129
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1 NCF1B	1.03e-05	3	65	2	21570954
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1 NCF1B	1.03e-05	3	65	2	25565313
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1 NCF1B	1.03e-05	3	65	2	39357591
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1 NCF1B	1.03e-05	3	65	2	12958309
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1 NCF1B	1.03e-05	3	65	2	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1 NCF1B	1.03e-05	3	65	2	31118934
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1 NCF1B	1.03e-05	3	65	2	23482812
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1 NCF1B	1.03e-05	3	65	2	16041040
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1 NCF1B	1.03e-05	3	65	2	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1 NCF1B	1.03e-05	3	65	2	10987289
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1 NCF1B	1.03e-05	3	65	2	21435178
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1 NCF1B	1.03e-05	3	65	2	18703411
Pubmed	Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.	NCF1 NCF1B	1.03e-05	3	65	2	29228045
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1 NCF1B	1.03e-05	3	65	2	17307863
Pubmed	Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.	NCF1 NCF1B	1.03e-05	3	65	2	22155727
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1 NCF1B	1.03e-05	3	65	2	27829407
Pubmed	Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.	NCF1 NCF1B	1.03e-05	3	65	2	24576409
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1 NCF1B	1.03e-05	3	65	2	22376231
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1 NCF1B	1.03e-05	3	65	2	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1 NCF1B	1.03e-05	3	65	2	28274989
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1 NCF1B	1.03e-05	3	65	2	26645958
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1 NCF1B	1.03e-05	3	65	2	12364355
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1 NCF1B	1.03e-05	3	65	2	24549323
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1 NCF1B	1.03e-05	3	65	2	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1 NCF1B	1.03e-05	3	65	2	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1 NCF1B	1.03e-05	3	65	2	10670582
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1 NCF1B	1.03e-05	3	65	2	20881184
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1 NCF1B	1.03e-05	3	65	2	26528554
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1 NCF1B	1.03e-05	3	65	2	19052348
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1 NCF1B	1.03e-05	3	65	2	20864666
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1 NCF1B	1.03e-05	3	65	2	23328631
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1 NCF1B	1.03e-05	3	65	2	34572995
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1 NCF1B	1.03e-05	3	65	2	17114280
Pubmed	Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.	NCF1 NCF1B	1.03e-05	3	65	2	19168575
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1 NCF1B	1.03e-05	3	65	2	25989352
Pubmed	NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.	NCF1 NCF1B	1.03e-05	3	65	2	19503084
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1 NCF1B	1.03e-05	3	65	2	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1 NCF1B	1.03e-05	3	65	2	17332431
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1 NCF1B	1.03e-05	3	65	2	36592568
Pubmed	Genetic requirement of p47phox for superoxide production by murine microglia.	NCF1 NCF1B	1.03e-05	3	65	2	11156938
Pubmed	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.	NCF1 NCF1B	1.03e-05	3	65	2	30504842
Pubmed	Genomic structure of the human p47-phox (NCF1) gene.	NCF1 NCF1B	1.03e-05	3	65	2	10772875
Pubmed	A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification.	NCF1 NCF1B	1.03e-05	3	65	2	27798190
Pubmed	Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.	NCF1 NCF1B	1.03e-05	3	65	2	20702812
Pubmed	Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.	NCF1 NCF1B	1.03e-05	3	65	2	33705493
Pubmed	Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.	NCF1 NCF1B	1.03e-05	3	65	2	23965970
Pubmed	Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.	NCF1 NCF1B	1.03e-05	3	65	2	26455429
Pubmed	Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.	NCF1 NCF1B	1.03e-05	3	65	2	15513930
Pubmed	Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.	NCF1 NCF1B	1.03e-05	3	65	2	15626477
Pubmed	Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.	NCF1 NCF1B	1.03e-05	3	65	2	15033459
Pubmed	NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.	NCF1 NCF1B	1.03e-05	3	65	2	19077231
Pubmed	Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.	NCF1 NCF1B	1.03e-05	3	65	2	20828610
Pubmed	p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.	NCF1 NCF1B	1.03e-05	3	65	2	20817944
Pubmed	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.	NCF1 NCF1B	1.03e-05	3	65	2	22319452
Pubmed	Early determinants of H2O2-induced endothelial dysfunction.	NCF1 NCF1B	1.03e-05	3	65	2	16895801
Pubmed	Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.	NCF1 NCF1B	1.03e-05	3	65	2	20690191
Pubmed	Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.	NCF1 NCF1B	1.03e-05	3	65	2	16772302
Pubmed	Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.	NCF1 NCF1B	1.03e-05	3	65	2	32504071
Pubmed	Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.	NCF1 NCF1B	1.03e-05	3	65	2	16280459
Pubmed	Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.	NCF1 NCF1B	1.03e-05	3	65	2	18185592
Pubmed	NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.	NCF1 NCF1B	1.03e-05	3	65	2	36853827
Pubmed	Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.	NCF1 NCF1B	1.03e-05	3	65	2	23024271
Pubmed	Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.	NCF1 NCF1B	1.03e-05	3	65	2	21253614
Pubmed	Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.	NCF1 NCF1B	1.03e-05	3	65	2	25873172
Pubmed	Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.	NCF1 NCF1B	1.03e-05	3	65	2	15310853
Pubmed	Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.	NCF1 NCF1B	1.03e-05	3	65	2	31393787
Pubmed	Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.	NCF1 NCF1B	1.03e-05	3	65	2	10725280
Pubmed	Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.	NCF1 NCF1B	1.03e-05	3	65	2	34970267
Pubmed	Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility.	NCF1 NCF1B	1.03e-05	3	65	2	25689796
Pubmed	Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.	NCF1 NCF1B	1.03e-05	3	65	2	14993144
Pubmed	Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation.	NCF1 NCF1B	1.03e-05	3	65	2	22050439
Pubmed	The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.	NCF1 NCF1B	1.03e-05	3	65	2	12031896
Pubmed	NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion.	NCF1 NCF1B	1.03e-05	3	65	2	11249873
Pubmed	Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.	NCF1 NCF1B	1.03e-05	3	65	2	15936744
Pubmed	NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation.	NCF1 NCF1B	1.03e-05	3	65	2	17220182
Pubmed	NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse.	NCF1 NCF1B	1.03e-05	3	65	2	25628043
Pubmed	The p47phox mouse knock-out model of chronic granulomatous disease.	NCF1 NCF1B	1.03e-05	3	65	2	7650482
Pubmed	Disseminated trichosporonosis in a murine model of chronic granulomatous disease.	NCF1 NCF1B	1.03e-05	3	65	2	12868577
Pubmed	Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.	NCF1 NCF1B	1.03e-05	3	65	2	12560337
Pubmed	NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia.	NCF1 NCF1B	1.03e-05	3	65	2	20859296
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	2.06e-04	9	44	2	1230
GeneFamily	Dyneins, axonemal	DNAH7 DNAH11	7.69e-04	17	44	2	536
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC1 ZDHHC4	1.54e-03	24	44	2	76
GeneFamily	Transient receptor potential cation channels	TRPM5 TRPM7	2.10e-03	28	44	2	249
GeneFamily	Sulfotransferases, membrane bound	NDST3 CHST9	3.65e-03	37	44	2	763
GeneFamily	WD repeat domain containing	FBXW8 IFT172 NBEA LRBA	3.71e-03	262	44	4	362
GeneFamily	Fibronectin type III domain containing	IL12RB2 EPHA2 CNTN1	6.91e-03	160	44	3	555
CoexpressionAtlas	ratio_StemCell_vs_induced-DefinitiveEndoderm_top-relative-expression-ranked_500_k-means-cluster#4	IL12RB2 ADGRG3 CALCRL TRIM22 CNTN1	5.23e-06	86	62	5	ratio_SC_vs_DE_500_K4
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CENPN ASPM TIMELESS RRM2 COQ2 KYAT1	4.20e-07	199	64	6	3d876f172487425b37b2f658dae59e0f293ee76e
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB2 CENPN TIMELESS ARHGAP35 RRM2	4.12e-06	166	64	5	21ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ADGRG3 MROH2A CALCRL RYR3	5.32e-06	175	64	5	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	Dividing_Macrophages-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	FANCD2 CENPN ASPM TIMELESS RRM2	5.78e-06	178	64	5	1893fadac2ec3d5de0a641e57b7b2f962012a9ba
ToppCell	control-Lymphoid-NKT-proliferating\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FANCD2 IL12RB2 CENPN ASPM RRM2	6.11e-06	180	64	5	535535a67b3f3320bad2f98b1bc98a7b0ee77840
ToppCell	RA-16._Neuronal\|World / Chamber and Cluster_Paper	RELN PTPN13 TSPAN11 NIBAN2 CNTN1	6.27e-06	181	64	5	7d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPN13 TSPAN11 CHST9 CNTN1 DNAH11	6.27e-06	181	64	5	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	P28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FANCD2 LHX2 CENPN ASPM RRM2	6.27e-06	181	64	5	e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPN13 TSPAN11 CHST9 CNTN1 DNAH11	6.27e-06	181	64	5	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	P28-Endothelial-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FANCD2 LHX2 CENPN ASPM RRM2	6.27e-06	181	64	5	2be3d44619adb25d339e7a27b500a56e07e8de01
ToppCell	5'-Adult-Appendix-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPN13 TSPAN11 CHST9 CNTN1 DNAH11	6.27e-06	181	64	5	e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell	mild_COVID-19_(asymptomatic)-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	FANCD2 CENPN ASPM TIMELESS RRM2	6.44e-06	182	64	5	9adf90bb2808f234d53b89ca0ae07380478204ad
ToppCell	mild_COVID-19_(asymptomatic)-T/NK_proliferative\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	FANCD2 CENPN ASPM TIMELESS RRM2	6.62e-06	183	64	5	df8568751205313d149939ea2683097e3652a60b
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MROH2A RYR3 CNTN1 DNAH11	6.79e-06	184	64	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MROH2A RYR3 CNTN1 DNAH11	6.79e-06	184	64	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MROH2A RYR3 CNTN1 DNAH11	6.79e-06	184	64	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Bac-SEP-Lymphocyte-T_NK-T_NK_proliferative\|Bac-SEP / Disease, Lineage and Cell Type	FANCD2 IL12RB2 CENPN ASPM RRM2	6.79e-06	184	64	5	848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|368C / Donor, Lineage, Cell class and subclass (all cells)	EPHA2 SCNN1G NBEA LRBA DNAH11	7.35e-06	187	64	5	b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	EPHA2 SCNN1G NBEA LRBA DNAH11	7.35e-06	187	64	5	61c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCell	10x5'-Liver-Lymphocytic_NK-Cycling_NK\|Liver / Manually curated celltypes from each tissue	FANCD2 CENPN ASPM TIMELESS RRM2	7.54e-06	188	64	5	5eb94e652a734c6f15c68a178e9d05f0febcf34c
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CENPN NIPSNAP1 ASPM ALG3 RRM2	7.54e-06	188	64	5	15146fd2c5592ea84d20b1fdd172b39cd60b5bed
ToppCell	droplet-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LHX2 CENPN ASPM TIMELESS RRM2	7.54e-06	188	64	5	0ec2a1b0505501ba18f10a5fce68c306a6292419
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 CLCN5 RYR3 CNTN1 ITPR3	7.74e-06	189	64	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	wk_08-11-Epithelial-PNS-Early_Schwann\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DOCK1 RELN TSPAN11 EPHA2 KYAT1	7.94e-06	190	64	5	8190674a48607984726974765aafbca116f437e0
ToppCell	wk_20-22-Hematologic_Lymphocytic-NK-Cycling_NK\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FANCD2 IL12RB2 CENPN ASPM RRM2	8.14e-06	191	64	5	5d4fed25bd318472a17228b12ade4c331865bda5
ToppCell	Mild-T/NK_proliferative\|World / Disease group and Cell class	FANCD2 CENPN ASPM TIMELESS RRM2	8.14e-06	191	64	5	9dba5526fd5ea8065ad305feb2ee562335f887c6
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FANCD2 CENPN ASPM TIMELESS RRM2	8.14e-06	191	64	5	50854384fdaa0efa2e3227659d544ed09ac102f2
ToppCell	15-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	IFT172 EPHA2 NBEA DNAH7 DNAH11	8.35e-06	192	64	5	9cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FANCD2 CENPN ASPM TIMELESS RRM2	8.78e-06	194	64	5	f9070035553bc68106a9e0bdf4b507715a138aba
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FANCD2 NDST3 ASPM TIMELESS RRM2	8.78e-06	194	64	5	590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell	Control-Lymphocyte-T_NK-T_NK_proliferative\|Control / Disease, Lineage and Cell Type	FANCD2 CENPN ASPM TIMELESS RRM2	8.78e-06	194	64	5	844731b7943d1cfca819b7b89e4e62067bfa0230
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating\|367C / Donor, Lineage, Cell class and subclass (all cells)	CENPN ASPM TIMELESS RRM2 COQ2	8.78e-06	194	64	5	a12b64945e10f00aa983678a02586c59badc1570
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_Progenitors\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	9.23e-06	196	64	5	5905f0e3061a6b98b7a33d64c782c3dda2cd51ef
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FANCD2 CENPN ASPM TIMELESS RRM2	9.23e-06	196	64	5	1d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	ASPM CHST9 RRM2 DNAH7 DNAH11	9.23e-06	196	64	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	ASPM CHST9 RRM2 DNAH7 DNAH11	9.23e-06	196	64	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	Mild_COVID-19-T/NK-proliferating_T/NK\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	5fd52fba2cb6fa67377f873da2ff6ce9c83b0591
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	84ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / Disease condition and Cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	718a84e9a8248080f2d964e7c6a3ba183ece9592
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	d7a9296092153cf66426911fecd810f0c1ef978e
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	dcff23240bb7cb652d7426b29355aa74442ef6fc
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	434a5686a103bb766e0d80038413f0e12ea3981a
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	8b616cde333bdbc0c591035ad9e4949155866245
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	6bddfa199ca812d9e518eaa02c3d4fb67e9f5b16
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	c0a71a9452febda433bc544e4ac0a79c43dcf13e
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.46e-06	197	64	5	f34b1e34f1f0694564031077172c890b233ce8b7
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IFT172 NBEA CHST9 DNAH7 DNAH11	9.46e-06	197	64	5	d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCell	distal-Hematologic-Proliferating_NK/T-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	5c14b152912429f099dfcb6bcb1aec80314a3284
ToppCell	COVID-19_Moderate-T/NK_proliferative\|COVID-19_Moderate / disease group, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	166c000fb0e19602ffdd8bf2b2f19be2c6df96a6
ToppCell	distal-3-Hematologic-Proliferating_NK/T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	aa23119d73554733981df474648e59918d04edfc
ToppCell	COVID-19_Moderate-T/NK_proliferative\|World / disease group, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	bf0131fbca6032e1aab4aa807f8c1d3be689cb7f
ToppCell	distal-1-Hematologic-Proliferating_Macrophage\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	df3f5559ecd1f3cd1fd60e39dbad8741309e83a3
ToppCell	distal-Hematologic-Proliferating_Macrophage-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	2b0716e900bce54ad1825d6dcdaf4ebf31f355c4
ToppCell	COVID-19_Severe-T/NK_proliferative\|World / disease group, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	48045689d0969ff0a14eee7086b8e19b0d6b6065
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating-cycling_dorsal_progenitors\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	dada1c19a261c8e1090957cd7e37f2a43a9fe14f
ToppCell	cycling_basal_cell\|World / shred by cell class for turbinate	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	e86c1224f5b0890a50a25257628e90c790aae7cd
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG-11\|World / Primary Cells by Cluster	FANCD2 CENPN ASPM TIMELESS RRM2	9.69e-06	198	64	5	672c6faeed54e1397e12c0aac1a5cbd19c684f06
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IFT172 NBEA CHST9 DNAH7 DNAH11	9.69e-06	198	64	5	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	11c3d9fe811a4619347f47d2b0e94066e3085625
ToppCell	severe_influenza-T/NK_proliferative\|severe_influenza / disease group, cell group and cell class (v2)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	638b1491c47f2884daf1c1d38a779ad8e0f59c52
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	4394dcd1809f49e9bada8f5e115d5123356eae3e
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	e98ff036d04fc78dffef156bdc0d644532274067
ToppCell	remission-T/NK_proliferative\|remission / disease stage, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	303a5fc43a48b05b6f2060d99eef4adc36f8d4e3
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	36c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	305a9ade5bbe8e981e7c641c9a5e0c9f8ef60470
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	a99516a5760f49a69b0fe45a9b2316e393252966
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	c0ea391bb347b99b94b5d7f02612ede938986745
ToppCell	COVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Mild / Disease group, lineage and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	7feedb0bf84a3361c8ab5b6674ff64e8ff140c23
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	7beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	96af1f289552f38f2dfa181192eb3276f4c7d70b
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	123fbf2122aa221d8cbf3aef9361ba0982c07695
ToppCell	remission-T/NK_proliferative\|World / disease stage, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	f305f3a454b7d2170429bad087480ccccca19acd
ToppCell	COVID-19_Mild-T/NK_proliferative\|COVID-19_Mild / Disease condition and Cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	9f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCell	COVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Severe / Disease group, lineage and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	fba48342066aab41a8bcb20db40a6df0158e1cbe
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Convalescent / Disease group, lineage and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	893b78c661c529db07a5fcc3124d9b3d0f270fa5
ToppCell	COVID-19_Convalescent-T/NK_proliferative\|COVID-19_Convalescent / Disease condition and Cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	c608d953b852b67a4e36bd63d45f0deec3eefbd9
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	6b1304417cf9c44ca70d2bfc2b5acc1a206f25b6
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	5b18e18ddbf4bd53aa0d574d23092cb96da7f400
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / disease group, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	af78837f3a7641a5bd98765eef9cb4f86034048c
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	6df65f4c2f9a125e0c7c4f597fefc05a97fc8831
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	cb229aa3eb7b1cc47e76711b8fc18fce88a5cf08
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_Progenitors_nGenesUnder4k\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	2fbf94f7858250088e0f5ce1ff51892730a13ae8
ToppCell	Mild-T/NK_proliferative\|Mild / Disease group and Cell class	FANCD2 CENPN ASPM TIMELESS RRM2	9.93e-06	199	64	5	64a5c91243ee999ea21ffddd450d3e5fdbf6470b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	8f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells\|10w / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCell	distal-Hematologic-Proliferating_Macrophage\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	3835a8a9739b8cd5bf19c40765ef76907ac1ad38
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Stem_cells-Neuroepithelial_cell\|3m / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	2938a029fa0478be561574ace91f95c4a528b2d4
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Mild / Disease, condition lineage and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	6126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCell	Control-Control-Lymphocyte-T/NK-T/NK_proliferative\|Control / Disease, condition lineage and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	6cf63dd57f6bc0c42e7182322dd24ff9afbe9186
ToppCell	Biopsy_IPF-Epithelial-Proliferating_Epithelial_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	63c5402f050fdb12abab3c8b7f33d4914ae26b9b
ToppCell	severe-T/NK_proliferative\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	9d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors_nGenesUnder4k\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	8223d2c9b9e05b1d26e3de1bc0226d175af2e7b2
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Severe / Disease, condition lineage and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	0892603e604c2a945dd720685d45970f855bd5d3
ToppCell	mLN-T_cell-cycling_gd_T\|mLN / Region, Cell class and subclass	IL12RB2 ADGRG3 CENPN ASPM RRM2	1.02e-05	200	64	5	4efeef51f885ee8f6dd3911a536cc49e3c14da98
ToppCell	control-T/NK_proliferative\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	1da366e35a05f73253629663eeea1fed4ebd7b52
ToppCell	healthy_donor-Lymphocytic-Proliferative_Lymphocyte\|healthy_donor / Disease condition, Lineage, Cell class and subclass	FANCD2 CENPN ASPM TIMELESS RRM2	1.02e-05	200	64	5	e4eb915c29909cf8535a3603c68976545c05e54b
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1 NCF1B	4.47e-05	5	63	2	DOID:3265 (implicated_via_orthology)
Disease	atrioventricular septal defect (implicated_via_orthology)	IFT172 DNAH11	9.36e-05	7	63	2	DOID:0050651 (implicated_via_orthology)
Disease	asthma exacerbation measurement, response to corticosteroid	LHX2 RRM2 DNAH11	1.80e-04	51	63	3	EFO_0007614, GO_0031960
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1 NCF1B	2.92e-04	12	63	2	DOID:7148 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NDST3 NBEA LRBA ITPR3	3.18e-04	152	63	4	DOID:0060041 (implicated_via_orthology)
Disease	response to 5-fluorouracil, response to cyclophosphamide, chemotherapy-induced alopecia, response to doxorubicin	LHX2 SMARCA2	4.02e-04	14	63	2	EFO_0005400, GO_0036275, GO_1902518, GO_1902520
Disease	polycystic kidney disease (implicated_via_orthology)	IFT172 KIF3A	4.02e-04	14	63	2	DOID:0080322 (implicated_via_orthology)
Disease	carotid plaque build	TSPAN11 EPG5 ITPR3	7.81e-04	84	63	3	EFO_0006501
Disease	coagulation factor measurement	ASPM CNTN1	8.32e-04	20	63	2	EFO_0004634
Disease	Bronchiectasis	SCNN1G DNAH11	1.01e-03	22	63	2	C0006267
Disease	vasculitis	IL12RB2 P4HA2	1.20e-03	24	63	2	EFO_0006803
Disease	Adenoid Cystic Carcinoma	ASPM SMARCA2 SRCAP	1.29e-03	100	63	3	C0010606
Disease	lifestyle measurement	PPP1R3A P4HA2 NIPSNAP1 SMARCA2	1.62e-03	235	63	4	EFO_0010724
Disease	susceptibility to rheumatic fever measurement	RELN RYR3	1.64e-03	28	63	2	EFO_0008416
Disease	asthma, cardiovascular disease	LRRC3C P4HA2	1.88e-03	30	63	2	EFO_0000319, MONDO_0004979

Protein segments in the cluster

Peptide	Gene	Start	Entry
WKLFYLMHQVESENL	EPG5	721	Q9HCE0
IHRVAYTEIDWKAYM	ALG3	61	Q92685
YGHWYDRQKVMLKEI	DNAH11	2601	Q96DT5
NLQRYWLNYEAHLMK	ADGRG3	66	Q86Y34
YEVYHSLEEIQNWMH	CPA6	136	Q8N4T0
IIQSYYRMHVQQKKW	ASPM	1976	Q8IZT6
HWKQTVFYMEDYLTV	PRMT1	311	Q99873
IIYENILKYINMDSW	NDST3	131	O95803
LEHNMWNYLYFIVLV	ITPR3	2561	Q14573
RQWIQISDAVYHMVY	NIBAN2	266	Q96TA1
MVAYLVHYVWQNRDE	LRRC3C	236	A6NJW4
VMWTLIYDTIYAHQD	COQ2	241	Q96H96
LLNDYWVHNEMKAEI	nan	256	O00370
DVWYMKRHIDYSRQQ	IL12RB2	326	Q99665
DYRMNQKLWEVYSGH	FBXW8	501	Q8N3Y1
WFVQIAMALQYLHEK	NEK4	111	P51957
SQHYVYMFLVKWQDL	NCF1	21	P14598
YWQKEVRLQLYHMAL	GPR119	281	Q8TDV5
PQKWYMVTIVHIYNR	LRBA	296	P50851
SDRYYLLAVDKQWHM	LHX2	61	P50458
IPRDYQEMIENYVHW	KIF3A	596	Q9Y496
QKIYVYWEVQLERME	ITFG2	376	Q969R8
SQHYVRYMFLVKWQD	NCF1B	21	A6NI72
TWTLLHEMDYQKYIS	RELN	2986	P78509
HYLEAQEWKATVNMY	IFT172	1051	Q9UG01
DYYHTVLWMEQVLKQ	P4HA2	181	O15460
LVYVRMSLDDWQTHY	PPP1R3A	156	Q16821
MHCYLDLVYQQWTES	PAPPA2	826	Q9BXP8
AWVYYHMDQLEEAQK	IFIT5	101	Q13325
LYQEIIHYFDKGKMW	DOCK1	1276	Q14185
EWLESIKMQQYTEHF	EPHA2	911	P29317
VGMEQLAYYHQEWTV	CLCN5	541	P51795
HVLEKIVESYQIRYW	CNTN1	831	Q12860
RYYWQENHLETKMIN	DNAH7	1271	Q8WXX0
IIYMQFHQHQKVWEV	CENPN	71	Q96H22
AYEMALKKYHGWIVQ	GLTP	131	Q9NZD2
LQAHWQLMKQYYLLE	MCRS1	251	Q96EZ8
SGINAIQEWYKLHYM	SCNN1G	221	P51170
IVVAVFAEKQHLMWY	CALCRL	241	Q16602
DSQQIHEEKLLYWNM	FANCD2	1256	Q9BXW9
VEKIHIYSLGMTLYW	PTPN13	96	Q12923
IWYKGQMKDLYHYIT	PSG3	66	Q16557
REKAVSLHLYLMWIY	MROH2A	966	A6NES4
WDENVYYTVPLVRHM	NIPSNAP1	256	Q9BPW8
MKHTYINVWTKEYEG	TAS2R36	146	P0DTE0
KNYHWLNDEVINFYM	SENP2	406	Q9HC62
HYQLQGLEWMVSLYN	SMARCA2	726	P51531
EKLNFINTYIMHIWE	OVCH1	1071	Q7RTY7
INTYIMHIWENSVYD	OVCH1	1076	Q7RTY7
ITDEVYQWMVYDGHQ	KYAT1	211	Q16773
QPRKWYMISIVHIYN	NBEA	321	Q8NFP9
LQLMHTLKYYYWVIN	NBEA	641	Q8NFP9
YQHIGLDWLVTMYEK	SRCAP	621	Q6ZRS2
QWLEESVYMDIYGKH	ARHGAP35	466	Q9NRY4
LLFMYLQVWIEEQHT	CHST9	26	Q7L1S5
LREKAQQHDETYYMW	TIMELESS	366	Q9UNS1
MFWKFQRYNLIVEYH	TRPM5	991	Q9NZQ8
VIFPIEYHDIWQMYK	RRM2	81	P31350
HTGQESYVWKMYQER	RYR3	4836	Q15413
HATVYSQEKMLDIYW	RNF123	826	Q5XPI4
LHLVLQGMVYTEYTW	ZDHHC4	71	Q9NPG8
MELYQHLESKEWFVQ	ACP6	361	Q9NPH0
MAHYKTEQDDWLIIY	TSPAN11	1	A1L157
NYQHMLRVIKKYWLQ	PLBD2	266	Q8NHP8
WQKELYKHVMRGNYE	ZNF746	116	Q6NUN9
MLQVLKELTDVQYYW	TRIM22	286	Q8IYM9
ISNIVWKYQRYHFIM	TRPM7	1106	Q96QT4
LMWHKLTTYEYIVQH	ZDHHC1	271	Q8WTX9