Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	phosphatase complex	PPP1R3A PPP4R3B PPP2R2A PPP4R3A	9.26e-05	55	90	4	GO:1903293
GeneOntologyCellularComponent	protein serine/threonine phosphatase complex	PPP1R3A PPP4R3B PPP2R2A PPP4R3A	9.26e-05	55	90	4	GO:0008287
GeneOntologyCellularComponent	protein phosphatase 4 complex	PPP4R3B PPP4R3A	2.72e-04	6	90	2	GO:0030289
Domain	Spectrin/alpha-actinin	SESTD1 DSP SYNE1 SPTA1	1.50e-05	32	88	4	IPR018159
Domain	SPEC	SESTD1 DSP SYNE1 SPTA1	1.50e-05	32	88	4	SM00150
Domain	SMK-1	PPP4R3B PPP4R3A	2.19e-05	2	88	2	PF04802
Domain	DUF625	PPP4R3B PPP4R3A	2.19e-05	2	88	2	IPR006887
Domain	Spectrin_repeat	DSP SYNE1 SPTA1	3.38e-04	29	88	3	IPR002017
Domain	WH1	PPP4R3B PPP4R3A	1.66e-03	13	88	2	PS50229
Domain	Dynein_heavy_chain_D4_dom	DNAH9 DNAH14	1.93e-03	14	88	2	IPR024317
Domain	FN_type2_col-bd	IGF2R LY75	1.93e-03	14	88	2	IPR000562
Domain	FN2_2	IGF2R LY75	1.93e-03	14	88	2	PS51092
Domain	Dynein_HC_stalk	DNAH9 DNAH14	1.93e-03	14	88	2	IPR024743
Domain	Myotubularin-like_Pase_dom	SBF2 MTMR10	1.93e-03	14	88	2	IPR010569
Domain	MT	DNAH9 DNAH14	1.93e-03	14	88	2	PF12777
Domain	AAA_8	DNAH9 DNAH14	1.93e-03	14	88	2	PF12780
Domain	PPASE_MYOTUBULARIN	SBF2 MTMR10	1.93e-03	14	88	2	PS51339
Domain	Myotubularin_fam	SBF2 MTMR10	1.93e-03	14	88	2	IPR030564
Domain	Myotub-related	SBF2 MTMR10	1.93e-03	14	88	2	PF06602
Domain	fn2	IGF2R LY75	1.93e-03	14	88	2	PF00040
Domain	FN2_1	IGF2R LY75	1.93e-03	14	88	2	PS00023
Domain	FN2	IGF2R LY75	1.93e-03	14	88	2	SM00059
Domain	BTB_2	KCNV1 KCTD19 KCTD10	2.00e-03	53	88	3	PF02214
Domain	T1-type_BTB	KCNV1 KCTD19 KCTD10	2.00e-03	53	88	3	IPR003131
Domain	DHC_fam	DNAH9 DNAH14	2.21e-03	15	88	2	IPR026983
Domain	Dynein_heavy_dom	DNAH9 DNAH14	2.21e-03	15	88	2	IPR004273
Domain	Dynein_heavy	DNAH9 DNAH14	2.21e-03	15	88	2	PF03028
Domain	GRAM	SBF2 TBC1D8B	2.52e-03	16	88	2	SM00568
Domain	PH_dom-like	PPP4R3B SBF2 TBC1D2B WDFY3 FERMT2 MTMR10 PPP4R3A	3.97e-03	426	88	7	IPR011993
Domain	-	RGS11 AXIN2	4.77e-03	22	88	2	1.10.196.10
Domain	DAPIN	NLRP1 MEFV	4.77e-03	22	88	2	PS50824
Domain	GRAM	SBF2 TBC1D8B	4.77e-03	22	88	2	PF02893
Domain	PYRIN	NLRP1 MEFV	4.77e-03	22	88	2	PF02758
Domain	MAGE_N	MAGEB10 MAGEC2	4.77e-03	22	88	2	PF12440
Domain	GRAM	SBF2 TBC1D8B	4.77e-03	22	88	2	IPR004182
Domain	DAPIN	NLRP1 MEFV	4.77e-03	22	88	2	IPR004020
Domain	RGS_subdom1	RGS11 AXIN2	4.77e-03	22	88	2	IPR024066
Domain	PYRIN	NLRP1 MEFV	4.77e-03	22	88	2	SM01289
Domain	MAGE_N	MAGEB10 MAGEC2	4.77e-03	22	88	2	IPR021072
Domain	Spectrin	SYNE1 SPTA1	5.21e-03	23	88	2	PF00435
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	AURKC CERK PPP2R2A MLH3 OBSL1 PEX1 RNF213 XPC NUP188 WDFY3 KAT6B CDKAL1 ADH4 NIN	1.06e-06	1116	90	14	31753913
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CDK12 SYNE1 OBSL1 KDM3B WDFY3 KAT6B NIN	2.05e-06	225	90	7	12168954
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	THBD IGF2R LOX RGS11 XPC AXIN2 DNMT3B ADH4	3.75e-06	351	90	8	20453000
Pubmed	PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.	ENPP1 ALKBH3	6.62e-06	2	90	2	22826605
Pubmed	Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.	PPP4R3B PPP4R3A	6.62e-06	2	90	2	16107728
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PPP4R3B CERK PPP2R2A CDK12 TBC1D2B KDM3B NUP188 KAT6B NIN	9.65e-06	529	90	9	14621295
Pubmed	Modulation of epigenetic factors during the early stages of HIV-1 infection in CD4+ T cells in vitro.	AURKC DNMT3B	1.98e-05	3	90	2	30077875
Pubmed	Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura.	AHCY DNMT3B	1.98e-05	3	90	2	18683034
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PHKA2 AURKC PPP2R2A CDK12 AHCY OBSL1 PEX1 NUP188 DCK MAP2K2 AXIN2	2.35e-05	910	90	11	36736316
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	PHKA2 ENPP1 OBSL1 PEX1 NIN	3.17e-05	139	90	5	25476789
Pubmed	Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells.	PPP4R3B PPP4R3A	3.96e-05	4	90	2	21423269
Pubmed	Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs.	AHCY DNMT3B	3.96e-05	4	90	2	17688412
Pubmed	Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis.	PPP4R3B PPP4R3A	3.96e-05	4	90	2	20876121
Pubmed	Next-generation sequencing to generate interactome datasets.	BTN2A2 GJB2 PNLIPRP1 PYROXD1 AHCY SEPTIN1 WDFY3 FERMT2 PIAS2 PRRC1 CTSW SNX1	4.01e-05	1147	90	12	21516116
Pubmed	SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization.	PIAS2 NIN	6.59e-05	5	90	2	16154161
Pubmed	Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation.	IGF2R DNMT3B	6.59e-05	5	90	2	20132320
Pubmed	Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.	IGF2R SNX1	6.59e-05	5	90	2	16214895
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	PHKA2 CDK12 SPTA1 RBM39	7.23e-05	85	90	4	16051665
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP4R3B ARHGAP32 PPP2R2A IGF2R PTPRB DSP SBF2 RNF213 MTMR10 PPP4R3A NIN	8.44e-05	1049	90	11	27880917
Pubmed	HIV-host interactome revealed directly from infected cells.	IGF2R LY75 DNAJC3 CTSW CDKAL1	8.73e-05	172	90	5	27375898
Pubmed	Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.	IGF2R SNX1	9.87e-05	6	90	2	17101778
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PPP4R3B SESTD1 DSP SYNE1 AHCY OBSL1 XPC WDFY3 PIAS2 MTMR10 SNX1 TRIM52	1.18e-04	1285	90	12	35914814
Pubmed	Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice.	IGF2R DNMT3B	1.38e-04	7	90	2	11934864
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PPP4R3B ZC3H7A DSP TBC1D2B OBSL1 PIAS2 PPP4R3A NIN	1.46e-04	588	90	8	38580884
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	AURKC KATNB1 AXIN2 NIN	1.47e-04	102	90	4	20508983
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	PPP4R3B PPP2R2A DSP PPP4R3A	1.64e-04	105	90	4	19156129
Pubmed	Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.	PIAS2 DNMT3B	1.84e-04	8	90	2	14752048
Pubmed	Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.	IGF2R DNMT3B	1.84e-04	8	90	2	15215868
Pubmed	A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.	PPP4R3B PPP4R3A	1.84e-04	8	90	2	18614045
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PHKA2 PPP2R2A SYNE1 KCTD10 CALCOCO1 AHCY XPC NUP188 RBM39 PRRC1 VPS13B	1.96e-04	1155	90	11	20360068
Pubmed	Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis.	PPP4R3B PPP4R3A	2.36e-04	9	90	2	28467410
Pubmed	Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.	PPP2R2A MAP2K2	2.36e-04	9	90	2	16239230
Pubmed	Tagging genes with cassette-exchange sites.	PPP2R2A CDK12 KCTD10 KAT6B RBM39 CDKAL1	2.41e-04	335	90	6	15741177
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	IGF2R SYNE1 TBC1D2B FERMT2 SNX1 CDKAL1	2.57e-04	339	90	6	37232246
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	MLH3 RFTN2 CTSW CDKAL1 SBNO2 DNMT3B	2.69e-04	342	90	6	23128233
Pubmed	A human MAP kinase interactome.	ZC3H7A ARHGAP32 DSP SYNE1 MAP2K2 PIAS2 PPP4R3A	2.74e-04	486	90	7	20936779
Pubmed	A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.	MLH3 IGF2R XPC DNMT3B	2.83e-04	121	90	4	19789190
Pubmed	Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City.	ENPP1 CDKAL1	2.94e-04	10	90	2	20503258
Pubmed	Evolution of the regulators of G-protein signaling multigene family in mouse and human.	SPTA1 RGS11 AXIN2	3.19e-04	51	90	3	11829488
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	RPGRIP1 AURKC CDK12 TBC1D2B NUP188 MAP2K2 PIAS2 RBM39	3.52e-04	670	90	8	22990118
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	SESTD1 ARHGAP32 TRPM5 FERMT2 MTMR10 NIN	3.70e-04	363	90	6	14691545
Pubmed	Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis.	PPP4R3B PPP4R3A	4.30e-04	12	90	2	29180410
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ZC3H7A IGF2R MTX2 MRS2 SYNE1 OBSL1 FERMT2 DNAJC3 VPS13B SNX1 CDKAL1 NIN	4.48e-04	1487	90	12	33957083
Pubmed	The protein interaction landscape of the human CMGC kinase group.	AURKC PPP2R2A CDK12 OBSL1 ALKBH3 NUP188 RBM39 AXIN2	4.49e-04	695	90	8	23602568
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PPP2R2A PTPRB SBF2 CALCOCO1 RNF213 KAT6B MAP2K2 DNAJC3 RBM39 VPS13B DNAH14 SBNO2	4.53e-04	1489	90	12	28611215
Pubmed	Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.	GJB2 SYNE1 DNMT3B	4.91e-04	59	90	3	32031713
Pubmed	Evolutionary plasticity of segmentation clock networks.	PPP4R3B AXIN2	5.91e-04	14	90	2	21652651
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	KCNV1 CDK12 KCTD10 USP24 AHCY KDM3B KAT6B MAP2K2	6.19e-04	730	90	8	34857952
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	RPGRIP1 HTR1B SEPTIN1 XPC PIAS2 MTMR10	6.32e-04	402	90	6	24722188
Pubmed	Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.	PPP1R3A THBD IGF2R ENPP1	6.69e-04	152	90	4	19578796
Pubmed	Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis.	LOX AXIN2	6.80e-04	15	90	2	30595533
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	CDKAL1 SBNO2	7.76e-04	16	90	2	19068216
Pubmed	Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.	RNF213 AXIN2	7.76e-04	16	90	2	29859889
Pubmed	Desmoplakin is essential in epidermal sheet formation.	GJB2 DSP	8.78e-04	17	90	2	11781569
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DSP CDK12 USP24 KDM3B XPC KAT6B MAP2K2 PPP4R3A	9.04e-04	774	90	8	15302935
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	PHKA2 CDK12 OBSL1 WDFY3 VPS13B AXIN2	9.17e-04	432	90	6	23455922
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	ARHGAP32 PPP2R2A ADAMTSL1 AHCY MAP2K2	9.31e-04	288	90	5	38496616
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	DSP SBF2 MTMR10 PRRC1	9.50e-04	167	90	4	25659891
Pubmed	A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.	PPP4R3B PPP4R3A	9.86e-04	18	90	2	16085932
Pubmed	Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.	MTX2 TKTL1	1.10e-03	19	90	2	17660561
Pubmed	The DNA sequence and analysis of human chromosome 6.	BTN2A2 HTR1B IGF2R MRS2 DSP ENPP1 SYNE1	1.17e-03	622	90	7	14574404
Pubmed	Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development.	GJB2 AXIN2	1.22e-03	20	90	2	21606200
Pubmed	Impaired stria vascularis integrity upon loss of E-cadherin in basal cells.	GJB2 AXIN2	1.22e-03	20	90	2	21925491
Pubmed	PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.	PPP4R3B PPP4R3A	1.22e-03	20	90	2	18715871
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPGRIP1 ZC3H7A DSP PYROXD1 SYNE1 SPTA1 RGS11 XPC TKTL1 DNAJC3 DNMT3B	1.24e-03	1442	90	11	35575683
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PPP4R3B PPP2R2A USP24 AHCY KDM3B NUP188 DCK FERMT2 PRRC1 SNX1 PPP4R3A	1.33e-03	1455	90	11	22863883
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ARHGAP32 USP24 KDM3B XPC WDFY3 MAP2K2 PIAS2	1.36e-03	638	90	7	31182584
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	ADAMTSL1 PNLIPRP1 SPTA1	1.37e-03	84	90	3	15203218
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SYNE1 SPTA1 RNF213 ZNF616	1.44e-03	187	90	4	26460568
Pubmed	Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.	PPP2R2A SPTA1 MAP2K2	1.47e-03	86	90	3	10862698
Pubmed	Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation.	MAP2K2 AXIN2	1.48e-03	22	90	2	25926459
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PHKA2 CDK12 ENPP1 OBSL1 KDM3B PEX1 SBNO2	1.51e-03	650	90	7	38777146
Pubmed	Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.	DSP NIN	1.62e-03	23	90	2	19841136
Pubmed	Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.	KCTD10 RBM39 SNX1	1.67e-03	90	90	3	31280863
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	ZC3H7A ARHGAP32 IGF2R DSP KATNB1 FERMT2 RBM39 NIN	1.67e-03	853	90	8	28718761
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	WDFY3 SNX1	1.76e-03	24	90	2	17452356
Pubmed	Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.	PHKA2 AHCY	1.76e-03	24	90	2	17937387
Pubmed	Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism.	SNX1 AXIN2	1.76e-03	24	90	2	32521258
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	PTPRB DSP SYNE1 CALCOCO1 DNAH9	1.77e-03	333	90	5	32665550
Pubmed	Systematic identification of pathological lamin A interactors.	THBD BTN2A2 GJB2 PNLIPRP1 PIAS2	1.86e-03	337	90	5	24623722
Pubmed	Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.	IGF2R SNX1	1.91e-03	25	90	2	15078902
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	USP24 AHCY	1.91e-03	25	90	2	35211260
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	IGF2R DSP ENPP1 CALCOCO1 USP24 AHCY KDM3B NUP188 DNAJC3 SNX1	1.93e-03	1297	90	10	33545068
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	PPP2R2A IGF2R DSP CDK12 USP24 AHCY FERMT2 MAP2K2	2.00e-03	878	90	8	37223481
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	PPP2R2A USP24 AHCY RNF213 NUP188	2.03e-03	344	90	5	36282215
Pubmed	Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development.	MAP2K2 DNMT3B	2.07e-03	26	90	2	27122033
Pubmed	Epidermal development requires ninein for spindle orientation and cortical microtubule organization.	DSP NIN	2.07e-03	26	90	2	30923192
Pubmed	WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.	PPP2R2A USP24 NLRP1	2.07e-03	97	90	3	25071155
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	PPP4R3B KCTD10 CDKAL1 PPP4R3A	2.16e-03	209	90	4	26389662
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	SESTD1 KCTD10 USP24 SNX1	2.28e-03	212	90	4	33853758
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	DSP SYNE1 TBC1D2B RNF213	2.36e-03	214	90	4	22199357
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	PPP2R2A DSP AHCY KDM3B SNX1	2.39e-03	357	90	5	37059091
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GREB1L SYNE1 SBF2	2.39e-03	102	90	3	11214970
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NLRP1 WDFY3 SBNO2	2.39e-03	102	90	3	10231032
Pubmed	Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse.	GJB2 AXIN2	2.40e-03	28	90	2	20346939
Pubmed	WFS1 Spectrum Disorder	PPP1R3A ENPP1	2.40e-03	28	90	2	20301750
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ARHGAP32 IGF2R DSP USP24 AHCY FERMT2 CDKAL1	2.44e-03	708	90	7	39231216
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	CDK12 CALCOCO1 ZNF616 DNAH9 RBM39	2.50e-03	361	90	5	26167880
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TBC1D2B USP24 KDM3B	2.53e-03	104	90	3	10470851
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|368C / Donor, Lineage, Cell class and subclass (all cells)	ZNF677 MRS2 ALKBH3 PEX1 SAMD3 CTSW TRIM52	1.11e-07	188	90	7	ecc2364d946f97ae0212fd6739960c9fc75e4919
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 TBC1D2B RNF213 SAMD3 FERMT2 CTSW	1.56e-06	176	90	6	5914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCell	COVID-19_Severe-gd_T\|COVID-19_Severe / Disease condition and Cell class	PPP4R3B IGF2R SYNE1 RNF213 CTSW PPP4R3A	2.02e-06	184	90	6	791f1bcb954aadc63d4117c400537d036f68734d
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK\|bone_marrow / Manually curated celltypes from each tissue	IGF2R SYNE1 RNF213 SAMD3 RBM39 CTSW	2.66e-06	193	90	6	e790ab76c12f74a13936c231076f1e397283efb3
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK-NK_CD16\|bone_marrow / Manually curated celltypes from each tissue	IGF2R SYNE1 RNF213 SAMD3 RBM39 CTSW	2.74e-06	194	90	6	7773501e076d470158dbc1d7f10c67152b326eb7
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 USP24 RNF213 SAMD3 RBM39 VPS13B	3.17e-06	199	90	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	severe-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IGF2R SYNE1 RNF213 SAMD3 RBM39 CTSW	3.27e-06	200	90	6	d6767f06fe13be8110a86c2a6029be2dd9ce666c
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB2 SEPTIN1 SAMD3 CTSW AXIN2	1.58e-05	155	90	5	7a16df1a40c7255c24dfb9a921b62871554c7b6d
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB2 SEPTIN1 SAMD3 CTSW AXIN2	1.58e-05	155	90	5	f51a12556ca0a3416a6cf0687f908fb4e752fb2f
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	MAGEB10 ENPP1 SYNE1 RNF213 SAMD3	1.63e-05	156	90	5	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	facs-GAT-Fat-18m-Lymphocytic-NK_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB2 SEPTIN1 SAMD3 CTSW ADH4	1.79e-05	159	90	5	796e63f6052189106359a4e01eae3e466bf1d593
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45____NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPTIN1 TKTL1 SAMD3 CTSW DNMT3B	2.01e-05	163	90	5	a763c1632d6465a1e753bdc8eadaf819d2b09e5e
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPTIN1 TKTL1 SAMD3 CTSW DNMT3B	2.01e-05	163	90	5	eaed783eecd07aafa5af844b63c9d816b4da99e4
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTA1 SEPTIN1 RGS11 SAMD3 CTSW	2.01e-05	163	90	5	924c666596bbb42d7876c9b164a725277f3efa5f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RPGRIP1 CLXN SYNE1 RFTN2 AXIN2	2.13e-05	165	90	5	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RPGRIP1 CLXN SYNE1 RFTN2 AXIN2	2.13e-05	165	90	5	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RPGRIP1 CLXN SYNE1 RFTN2 AXIN2	2.13e-05	165	90	5	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	facs-Heart-RA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPTIN1 TKTL1 SAMD3 LY75 CTSW	2.83e-05	175	90	5	db977f18a71845ecb16ee3e6b3fb03dea4a1a8bc
ToppCell	facs-Heart-RA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPTIN1 TKTL1 SAMD3 LY75 CTSW	2.83e-05	175	90	5	7b38cbd73be26cf33393c6e6c804d62856a91ec3
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPTIN1 TKTL1 SAMD3 DNAJC3 CTSW	2.99e-05	177	90	5	dba8b30a311051c22ca5f77697f5dbf9423c3ba0
ToppCell	facs-Heart-LA-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR1B SEPTIN1 TKTL1 SAMD3 CTSW	3.07e-05	178	90	5	d32b4e9c3d1f246ad49e2d8f6497989af68a6c00
ToppCell	facs-Heart-RA-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPTIN1 TKTL1 SAMD3 LY75 CTSW	3.07e-05	178	90	5	ba6ded4455233635a11afcf6f522c786bd81b5e0
ToppCell	facs-Heart-LA-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR1B SEPTIN1 TKTL1 SAMD3 CTSW	3.07e-05	178	90	5	b7abf5656233e1a9cdbbe978dfa84d16f14b0be0
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_NK\|GI_small-bowel / Manually curated celltypes from each tissue	SYNE1 KCTD10 TKTL1 SAMD3 CTSW	3.15e-05	179	90	5	535bdfdd990ba9ee3edc8f3ad15297f8fb5a266e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZC3H7A TBC1D2B SAMD3 CTSW VPS13B	3.15e-05	179	90	5	db76edd368eeca05a2a5d407c3eb2f535ade0ce3
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	IGF2R SYNE1 RNF213 SAMD3 CTSW	3.50e-05	183	90	5	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	normal-na-Lymphocytic_NK-NK_dim-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SYNE1 RNF213 SAMD3 RBM39 CTSW	3.69e-05	185	90	5	b1a8a8c4d0fc7605eabc17dcb6bd9e8ab4fd578c
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF2R SEPTIN1 SAMD3 CTSW AXIN2	3.78e-05	186	90	5	4dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCell	10x5'v1-week_12-13-Lymphocytic_T-T_NK-NK_T_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SEPTIN1 TKTL1 SAMD3 FERMT2 CTSW	3.78e-05	186	90	5	b099cb0902e9afb11218d70407d3cab212343c6d
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF2R SEPTIN1 SAMD3 CTSW AXIN2	3.78e-05	186	90	5	e23e1246914e230369a716d0d666b98383bf8512
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 RNF213 SAMD3 RBM39 CTSW	4.08e-05	189	90	5	0e8d1be3c406d1a393e18faccfe89116a8f82bcf
ToppCell	10x5'-blood-Lymphocytic_T_CD8-Trm/em_CD8\|blood / Manually curated celltypes from each tissue	SYNE1 SEPTIN1 SAMD3 CTSW NIN	4.19e-05	190	90	5	e1f474dc36bf9eaf457b14a8761d287904754cdc
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEPTIN1 RNF213 TKTL1 SAMD3 CTSW	4.29e-05	191	90	5	753deb090b7b78b4ef31604dbe5dbfc4dcf5184a
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEPTIN1 RNF213 TKTL1 SAMD3 CTSW	4.29e-05	191	90	5	355f5bcb220d917163833dead0050fc756c7b260
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEPTIN1 RNF213 TKTL1 SAMD3 CTSW	4.29e-05	191	90	5	337d7d7b89fe370e1fe005b9daad76c5dc3b8444
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SYNE1 RNF213 TKTL1 SAMD3 CTSW	4.40e-05	192	90	5	fdc741e1846cfd8ed741b160e3c611c310c5d36d
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	IGF2R SBF2 WDFY3 PRRC1 VPS13B	4.51e-05	193	90	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 SAMD3 RBM39 CTSW TRIM52	4.62e-05	194	90	5	6be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCell	10x5'-Liver-Lymphocytic_NK\|Liver / Manually curated celltypes from each tissue	IGF2R SYNE1 KCTD10 SAMD3 CTSW	4.62e-05	194	90	5	0b78f4ed84bbaca9f72f005c16c7492bb01d4328
ToppCell	T_cells-CD56_dim_CD16+_NK_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	IGF2R SYNE1 KCTD10 SAMD3 CTSW	4.62e-05	194	90	5	335c6c2f3f319d4f19eace62f8826a0f40c130f6
ToppCell	T/NK_cells-CD8+_Naive_T_cell\|World / Lineage and Cell class	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	4.74e-05	195	90	5	43f11068beea076e9caeb1572215c3f65c9308e1
ToppCell	Control-CD8+_Tem\|Control / Disease condition and Cell class	SYNE1 RNF213 SAMD3 CTSW NIN	4.74e-05	195	90	5	7503b3e032f95b350a2782d28e4d412a8dc9ebcc
ToppCell	T_cells-GZMK+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	IGF2R SYNE1 RNF213 SAMD3 CTSW	4.74e-05	195	90	5	003ea7ddec6c1c98d2f6470bb51ebd97450eb936
ToppCell	wk_20-22-Hematologic_Lymphocytic-NK-CD16+_NK\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SEPTIN1 RNF213 TKTL1 SAMD3 CTSW	4.74e-05	195	90	5	7533822d2fe551f499b5b2fdec7172f56c79cb44
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	4.74e-05	195	90	5	cab90c67a7b3119c0d0d2d5e84511c41dcb8765f
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	SYNE1 RNF213 SAMD3 CTSW PPP4R3A	4.74e-05	195	90	5	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD8\|bone_marrow / Manually curated celltypes from each tissue	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	4.85e-05	196	90	5	5c9ed3c6e3cbd43b52f0291b5c26dd7f9fadf3da
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 RNF213 SAMD3 CTSW PPP4R3A	4.85e-05	196	90	5	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	4.85e-05	196	90	5	a9157809122e6fc5783a291522f103bef30943e4
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 RNF213 SAMD3 CTSW PPP4R3A	4.85e-05	196	90	5	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 RNF213 SAMD3 CTSW PPP4R3A	4.85e-05	196	90	5	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 RNF213 SAMD3 CTSW PPP4R3A	4.85e-05	196	90	5	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 RNF213 SAMD3 RBM39 CTSW	4.85e-05	196	90	5	17f17edadafdad9f24e88d708d7e1c765503131c
ToppCell	COVID-19_Severe-NK\|World / disease group, cell group and cell class	IGF2R SYNE1 RNF213 SAMD3 CTSW	4.85e-05	196	90	5	f46ca7cc2d8407d0dcaa77c4b16a2c1f2a23734d
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, condition lineage and cell class	THBD BTN2A2 ENPP1 AHCY OBSL1	4.97e-05	197	90	5	e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCell	COVID-19_Severe-NK_activated\|World / disease group, cell group and cell class	SYNE1 RNF213 TKTL1 SAMD3 CTSW	4.97e-05	197	90	5	a60db36d1a192998e3ded63e0c7c08d41689f95f
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	5.09e-05	198	90	5	24f6954aff8751885e783d68c631b04dd1980f48
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.09e-05	198	90	5	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 RNF213 TKTL1 SAMD3 CTSW	5.09e-05	198	90	5	0e918e9db9b884f5328d438e90efe065e27266ee
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SYNE1 SAMD3 KAT6B RBM39 CTSW	5.09e-05	198	90	5	34c564ece9a2b94dcf646e3c95b5be9c5ecfaafe
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	5.09e-05	198	90	5	4633e379893a26a746f8e29302cc54bbe04dd23f
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK\|COVID-19_Convalescent / Disease group, lineage and cell class	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	5.09e-05	198	90	5	457ba9e3f1bb6453af8cc1a6e7436af66296f8f5
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 RNF213 TKTL1 SAMD3 CTSW	5.09e-05	198	90	5	ce92d5fbc2eac27fb246b044fb1914ab92506275
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 RNF213 TKTL1 SAMD3 CTSW	5.09e-05	198	90	5	fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.09e-05	198	90	5	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 RNF213 TKTL1 SAMD3 CTSW	5.09e-05	198	90	5	1ef3a6bd681c223eed58300348adfef89df5563c
ToppCell	severe-NK\|severe / disease stage, cell group and cell class	SYNE1 RNF213 TKTL1 SAMD3 CTSW	5.09e-05	198	90	5	cb505077dc5bdf3fdd513bb9032e32bb9644c004
ToppCell	COVID-19_Severe-Lymphoid_T/NK-NK_activated\|COVID-19_Severe / Disease group, lineage and cell class	SYNE1 RNF213 TKTL1 SAMD3 CTSW	5.22e-05	199	90	5	edf5f80b4c299e6bf462675f2cd3329d86c923d8
ToppCell	COVID_non-vent-Lymphocytic-ILC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCell	COVID_vent-Lymphocytic-ILC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	e3ff7fa1b1de1aaf6b46cdf49afa95bad457728a
ToppCell	COVID-19_Moderate-NK\|World / disease group, cell group and cell class	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	c41b67b760831c7d5e19fabcc932a056dc560f93
ToppCell	COVID_non-vent-Lymphocytic-ILC-NK_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	4820f5bcd7bc34c2ebf6a3422cc8eb383a3b5a4e
ToppCell	healthy_donor-Lymphocytic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	2841e16d54acd344ba454f024e285c28abc37319
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CERK SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	eb05ccae5187e4701bbbe6d714a6d2808fbcf306
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	10c8729b779073c3bf808e85958d59147f0be5c5
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 SBF2 WDFY3 VPS13B CDKAL1	5.22e-05	199	90	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Control-NK\|Control / Disease condition and Cell class	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	f3316fb97c6065286ffd22a0ad9fe7aa5b3b5650
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	867fd292f3879982422e840e087bfdb3b21a8715
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	8f2b57cf2f932f20ea029132d8bda01aac774571
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	5e9fe852a70546c9d235414a2c26ca3e67ba6eb9
ToppCell	Control-Lymphoid_T/NK-NK\|Control / Disease group, lineage and cell class	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	94b2693a8378b9b2c58c6aebb2c6658d75b2e3de
ToppCell	COVID_vent-Lymphocytic-ILC-NK_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	5f914962e2572b0c6372465b81b7496fa663d93c
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.22e-05	199	90	5	d2c9fb69e5ef75778a1652da293fcf8cfa7ecfcc
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 RNF213 SAMD3 RBM39 CTSW	5.34e-05	200	90	5	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	MS-IIF-Lymphocyte-T/NK-NK\|IIF / Disease, condition lineage and cell class	RNF213 TKTL1 SAMD3 RBM39 CTSW	5.34e-05	200	90	5	4f889cc5ab76a128fd781d927b0d8368f4f927b7
ToppCell	severe-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 RNF213 SAMD3 RBM39 CTSW	5.34e-05	200	90	5	2253d74049cc49c92e897ff4aa298d913daeb739
ToppCell	Control-Control-Lymphocyte-T/NK-NK\|Control / Disease, condition lineage and cell class	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.34e-05	200	90	5	c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 RNF213 SAMD3 RBM39 CTSW	5.34e-05	200	90	5	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	mild-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IGF2R SYNE1 RNF213 SAMD3 CTSW	5.34e-05	200	90	5	a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCell	COVID-19-COVID-19_Convalescent-Lymphocyte-T/NK\|COVID-19_Convalescent / Disease, condition lineage and cell class	SYNE1 SEPTIN1 RNF213 SAMD3 CTSW	5.34e-05	200	90	5	e94acbc62f8e9835413981ba6d0590a356afa05e
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 SEPTIN1 TKTL1 SAMD3 CTSW	5.34e-05	200	90	5	0a6fc7eff94e2f71af9f31a01779aafd2f4a6699
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK_activated\|COVID-19_Severe / Disease, condition lineage and cell class	SYNE1 RNF213 TKTL1 SAMD3 CTSW	5.34e-05	200	90	5	6a77f9643646bafc1157bf1fc1e4c614860ee642
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	IGF2R SYNE1 USP24 RNF213 SAMD3	5.34e-05	200	90	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	severe-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 RNF213 SAMD3 RBM39 CTSW	5.34e-05	200	90	5	6aa77955017d073a96324e4db6b9950a2ec46cf8
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-NK\|Leuk-UTI / Disease, condition lineage and cell class	SYNE1 KCTD10 TKTL1 SAMD3 CTSW	5.34e-05	200	90	5	bb37fed4872e71f413ae7c4aa12586fa31075334
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GREB1L KCNV1 CLXN SAMD3	1.03e-04	120	90	4	a6d0406a174d46ce06b41280292931954af88a59
ToppCell	droplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	REP15 IGF2R MRS2 SPTA1	1.67e-04	136	90	4	a43b3db1754c619d328a26a2ba6af4756629a723
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEPTIN1 TKTL1 SAMD3 CTSW	1.86e-04	140	90	4	568a008ff103269e9fe36aa95e9d302641efed98
Drug	HMDS	SESTD1 ARHGAP32 SYNE1 TKTL1 DCK	1.67e-08	21	90	5	CID000013838
Drug	Diflorasone Diacetate [33564-31-7]; Down 200; 8uM; PC3; HT_HG-U133A	THBD MLH3 PTPRB LOX SYNE1 TBC1D8B CDKAL1 PPP4R3A	1.29e-06	200	90	8	4077_DN
Drug	2-propylpentanoic acid; Up 200; 50uM; HL60; HT_HG-U133A	MLH3 KRT24 PTPRB CALCOCO1 KATNB1 WDFY3 CDKAL1	1.37e-05	198	90	7	1163_UP
Drug	Cefotetan [69712-56-7]; Down 200; 7uM; HL60; HT_HG-U133A	BTN2A2 KATNB1 PEX1 NLRP1 WDFY3 DNAJC3 DNMT3B	1.42e-05	199	90	7	1319_DN
Disease	ischemia (biomarker_via_orthology)	THBD GJB2 HTR1B	2.02e-05	18	88	3	DOID:326 (biomarker_via_orthology)
Disease	lung adenocarcinoma (implicated_via_orthology)	GJB2 IGF2R	2.63e-05	3	88	2	DOID:3910 (implicated_via_orthology)
Disease	Hidradenitis Suppurativa	GJB2 MEFV	1.83e-04	7	88	2	C0162836
Disease	hepatocellular carcinoma (is_marker_for)	IGF2R PTPRB CDK12 MAP2K2 AXIN2 DNMT3B	2.88e-04	301	88	6	DOID:684 (is_marker_for)
Disease	glioblastoma (is_marker_for)	PTPRB ENPP1 MAP2K2	3.11e-04	44	88	3	DOID:3068 (is_marker_for)
Disease	Amino Acid Metabolism, Inherited Disorders	AHCY XPC	6.71e-04	13	88	2	C0750905
Disease	colon carcinoma (is_marker_for)	IGF2R AXIN2	6.71e-04	13	88	2	DOID:1520 (is_marker_for)
Disease	Amino Acid Metabolism, Inborn Errors	AHCY XPC	6.71e-04	13	88	2	C0002514
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	HTR1B RNF213 CDKAL1	1.27e-03	71	88	3	EFO_0004735, EFO_0007965
Disease	type 2 diabetes mellitus (is_implicated_in)	PPP1R3A IGF2R ENPP1 CDKAL1	1.74e-03	171	88	4	DOID:9352 (is_implicated_in)
Disease	anxiety disorder (implicated_via_orthology)	HTR1B KDM3B	1.95e-03	22	88	2	DOID:2030 (implicated_via_orthology)
Disease	Hepatic Form of Wilson Disease	LOX AHCY	2.33e-03	24	88	2	C1527352
Disease	Hepatolenticular Degeneration	LOX AHCY	2.33e-03	24	88	2	C0019202
Disease	Noonan Syndrome	KAT6B MAP2K2	2.33e-03	24	88	2	C0028326
Disease	urate measurement, bone density	SYNE1 ALKBH3 DCK KAT6B DNAH9 DNAH14 CDKAL1	2.53e-03	619	88	7	EFO_0003923, EFO_0004531
Disease	Micronuclei, Chromosome-Defective	PPP2R2A XPC	2.73e-03	26	88	2	C1449861
Disease	Micronuclei, Genotoxicant-Induced	PPP2R2A XPC	2.73e-03	26	88	2	C1449862
Disease	Colorectal cancer	MLH3 AXIN2	2.94e-03	27	88	2	cv:C0346629
Disease	COLORECTAL CANCER	MLH3 AXIN2	2.94e-03	27	88	2	114500
Disease	Neoplasm of the large intestine	MLH3 AXIN2	2.94e-03	27	88	2	cv:C0009404

Protein segments in the cluster

Peptide	Gene	Start	Entry
LFIKDVIGDEICCWS	KCTD10	201	Q9H3F6
FWRQAKAEEEVSECV	HTR1B	186	P28222
IEGRTYDEKVDLWCI	AURKC	211	Q9UQB9
ESDWGKRCVDKFDII	CDK12	716	Q9NYV4
KEDVLWCTELERIFG	DNMT3B	796	Q9UBC3
QWCFSQVKGAVDDDV	PPP2R2A	11	P63151
WEAGKPLCIEEVEVA	ADH4	16	P08319
FVDVKEADWILEQLC	ALKBH3	96	Q96Q83
PTLNEEEEWTCADFK	AXIN2	226	Q9Y2T1
KEVWGDEQADFVCNT	GJB2	41	P29033
FLDKILEVCVWDAEL	DNAJC3	176	Q13217
RSEVEEVDFAGWLCK	MAP2K2	371	P36507
GWDTEIKDDVIEECN	RBM39	441	Q14498
IVVEQWTVIEGCEIK	RFTN2	341	Q52LD8
DVVQWLAQKFCVSEE	RGS11	56	O94810
ALSFQEKAGCDEIWE	PPP4R3A	81	Q6IN85
SEFKEWPLFCQEVEE	KCTD19	461	Q17RG1
ELSWEKIECESGVED	KAT6B	701	Q8WYB5
EDWIQCFSIEKAGAV	OBSL1	561	O75147
WTIREFKICGEEQLD	PTPRB	1841	P23467
IFTNGNCVAEEEVWK	MAGEB10	211	Q96LZ2
VIFIKGNCASEEVIW	MAGEC2	236	Q9UBF1
QLCVNEPFEETEEKW	MTMR10	351	Q9NXD2
VLVCLEEGWDITAQV	SBF2	1406	Q86WG5
WDLEKFQVVSCIEGE	KATNB1	216	Q9BVA0
EDIQGHVTSVEEWKC	ADAMTSL1	406	Q8N6G6
EIQYWGIDELSIDSC	KCNV1	136	Q6PIU1
KLFEVEEVNCICVDW	PNLIPRP1	111	P54315
CHFEESGQDLEIWKE	MLH3	516	Q9UHC1
EIEFCVWDQFLGEIN	NLRP1	1126	Q9C000
EELCVSKWSDPQVFE	MRS2	266	Q9HD23
CAIISDVKVRDFWDG	KDM3B	1451	Q7LBC6
DVKVRDFWDGFEIIC	KDM3B	1456	Q7LBC6
QISALEEEICQIWGE	KRT24	406	Q2M2I5
DCVVLDTDGFWKTVD	LY75	1196	O60449
GEKSWVEEPCESINE	ENPP1	186	P22413
ALIGELEAKECQSEW	MEFV	511	O15553
ALSFQEKAGCDEIWE	PPP4R3B	81	Q5MIZ7
FWLESEVIIQVTDCE	ARHGAP32	16	A7KAX9
WIQLDTGEDVGCEEK	GREB1L	846	Q9C091
GFNLVSVKEFDCWEL	PPP1R3A	71	Q16821
CVDDTWNPKIFVVFD	PARP11	311	Q9NR21
FQEGVCEIWLTSEDT	CDKAL1	246	Q5VV42
GLEAAEDVEEWQVVC	CERK	371	Q8TCT0
EDVEEWQVVCGKFLA	CERK	376	Q8TCT0
LCEQECEWEEITITG	DSP	2496	P15924
WDFVDVSVQELLDCG	CTSW	171	P56202
SCWETQGEKFIENLI	DNAH14	3101	Q0VDD8
EVTRAEWEQKDEFIC	IGHE	391	P01854
GADIDCQWIDITDVK	LOX	356	P28300
TFVNILKQLCEDWEV	DCK	36	P27707
EETLNWKTEGICDYV	DNAH9	776	Q9NYC9
EQAKWAILLEEIECT	FERMT2	296	Q96AC1
EIKAQEDGSIWLECI	BTN2A2	156	Q8WVV5
VCNIGHFDVEIDVKW	AHCY	296	P23526
DWIGIFKVEAACVRD	CALCOCO1	46	Q9P1Z2
EEDEKACVLQVVWNG	PEX1	376	O43933
AELKLFENIECEWPV	PHKA2	316	P46019
SDVDEIKFQEDGSWC	PIAS2	411	O75928
ELYLQWCDEATVGEI	MTX2	126	O75431
EVRGCDVTFEWKTKV	IGF2R	1971	P11717
PIWEEQQCEVKADGF	THBD	151	P07204
AGWICFDRVLETVEK	RPGRIP1	716	Q96KN7
LEGKNTDEEIVECWH	SYNE1	2986	Q8NF91
TDEEIVECWHKGQEI	SYNE1	2991	Q8NF91
DWIEEKLQEVCEDLG	NIN	181	Q8N4C6
VEQVCSWLVEKNLGE	SAMD3	6	Q8N6K7
QILDWCGEAFEGVIV	SBNO2	371	Q9Y2G9
DKWFDIGCLVVEDPV	PRRC1	341	Q96M27
EVSLVCVVKPDEFWD	SESTD1	91	Q86VW0
DLVSWFEDCKEGKIE	C12orf29	236	Q8N999
FDKDNDGCVNVLEWI	CLXN	76	Q9HAE3
DCWLPVVKFIEEQFE	SEPTIN1	106	Q8WYJ6
RGCVTQLWSKEDEED	TRIM52	41	Q96A61
EEFGESKWDSNICEL	RNF213	406	Q63HN8
SIVEELCAWVEKFIN	RNF213	3186	Q63HN8
DVAIEFPQEEWKCLD	ZNF880	11	Q6PDB4
DVAIEFSQEEWKCLE	ZNF616	11	Q08AN1
LQACEELVKTLGFDW	WDFY3	1656	Q8IZQ1
VDIAKSEIFNGDVEW	TRPM5	361	Q9NZQ8
SEIFNGDVEWKSCDL	TRPM5	366	Q9NZQ8
DIWFEEKLQEVECEE	SNX1	306	Q13596
AKEEEAFWLLVAVCE	TBC1D8B	586	Q0IIM8
IEGCEVIWAIKDKAI	PYROXD1	166	Q8WU10
ELGELVFKDWSVVIE	TTC41P	236	Q6P2S7
KELCEVDEDGDSWLQ	NUP188	1291	Q5SRE5
IHFITFCQEKGVDEW	REP15	61	Q6BDI9
ECADILEWIGDKEAI	SPTA1	166	P02549
KDVAIEFSQEEWECL	ZNF677	11	Q86XU0
CQEEIDVWTLERKGA	ZC3H7A	526	Q8IWR0
AKEIWECLVTGQDVC	USP24	731	Q9UPU5
KEVLCWEQEGTTVEA	VPS13B	421	Q7Z7G8
IEFSQEEWKCLDPVQ	ZNF766	16	Q5HY98
AGIDQWLEVFCEQEE	XPC	526	Q01831
LEQEDAFWCLVTIVE	TBC1D2B	766	Q9UPU7
VVDGRDVEALCQVFW	TKTL1	186	P51854