Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.40e-1041094GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.40e-1041094GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.40e-1041094GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-0951094GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-0951094GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-0951094GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-0951094GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-0951094GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-0951094GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.18e-0951094GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.25e-0861094GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.90e-0871094GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.78e-0881094GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.78e-0881094GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.78e-0881094GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-0791094GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-0791094GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.72e-07101094GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.72e-07101094GO:0032052
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.06e-07141094GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.06e-07141094GO:0001758
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.81e-06201094GO:0004303
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.21e-06241094GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.14e-05261094GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.14e-05261094GO:0070402
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.34e-05271094GO:0008106
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

AKR1C4 NDUFB4 AKR1C1 AKR1C2 AKR1C3

1.90e-05601095GO:0016655
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.06e-05301094GO:0018455
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C3

2.53e-05111093GO:0030283
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.69e-05321094GO:0004033
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.04e-05331094GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.43e-05341094GO:0016628
GeneOntologyMolecularFunctionpoly(A)-specific ribonuclease activity

CNOT6 CNOT6L CNOT1

4.35e-05131093GO:0004535
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.96e-05391094GO:0016229
GeneOntologyMolecularFunctionRNA exonuclease activity, producing 5'-phosphomonoesters

DCP2 CNOT6 CNOT6L CNOT1

6.60e-05401094GO:0016896
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.60e-05401094GO:0016709
GeneOntologyMolecularFunctioncollagen binding

MAP1A ITGA3 CSPG4 PAK1 LRRC15

8.14e-05811095GO:0005518
GeneOntologyMolecularFunctionRNA exonuclease activity

DCP2 CNOT6 CNOT6L CNOT1

1.05e-04451094GO:0004532
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.36e-04481094GO:0016620
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

AKR1C4 NDUFB4 AKR1C1 AKR1C2 AKR1C3

1.73e-04951095GO:0016651
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

1.76e-0441092GO:0047718
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.48e-04561094GO:0016903
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-04621094GO:0016627
GeneOntologyMolecularFunctionNADP binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-04621094GO:0050661
GeneOntologyMolecularFunctionexonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

DCP2 CNOT6 CNOT6L CNOT1

3.67e-04621094GO:0016796
GeneOntologyMolecularFunctiontestosterone dehydrogenase (NAD+) activity

AKR1C4 AKR1C3

1.04e-0391092GO:0047035
GeneOntologyMolecularFunction3'-5'-RNA exonuclease activity

CNOT6 CNOT6L CNOT1

1.07e-03371093GO:0000175
GeneOntologyMolecularFunctionexonuclease activity

DCP2 CNOT6 CNOT6L CNOT1

1.62e-03921094GO:0004527
GeneOntologyMolecularFunctiongrowth factor binding

NLRP7 LRRC32 TSKU IGFALS LRP2

1.66e-031561095GO:0019838
GeneOntologyMolecularFunctionRoundabout binding

RTN4R IGFALS

1.88e-03121092GO:0048495
GeneOntologyMolecularFunctioncarboxylic acid binding

NRTN RTN4R AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.00e-032391096GO:0031406
GeneOntologyMolecularFunctionorganic acid binding

NRTN RTN4R AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.72e-032541096GO:0043177
GeneOntologyMolecularFunctionmonocarboxylic acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.82e-031071094GO:0033293
GeneOntologyMolecularFunctionmonooxygenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.65e-031151094GO:0004497
GeneOntologyMolecularFunction3'-5' exonuclease activity

CNOT6 CNOT6L CNOT1

4.53e-03611093GO:0008408
GeneOntologyMolecularFunctioninsulin-like growth factor binding

IGFALS LRP2

4.75e-03191092GO:0005520
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.19e-031271094GO:0016616
GeneOntologyMolecularFunctionsteroid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.11e-031331094GO:0005496
GeneOntologyMolecularFunctionRNA nuclease activity

DCP2 CNOT6 CNOT6L CNOT1

6.60e-031361094GO:0004540
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.94e-031381094GO:0016614
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.38e-1041094GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.38e-1041094GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.38e-1041094GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.38e-1041094GO:0008208
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-0951094GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-0951094GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-0951094GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-0951094GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-0951094GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.67e-0951094GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.10e-0861094GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.10e-0861094GO:0016095
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.55e-0871094GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.55e-0871094GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.55e-0871094GO:1900052
GeneOntologyBiologicalProcesshormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3 DIO3

7.15e-08211095GO:0042447
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3 CNOT1

7.15e-08211095GO:0048385
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.11e-0891094GO:0044597
GeneOntologyBiologicalProcessparturition

AKR1C4 AKR1C1 AKR1C2 PLA2G4B AKR1C3

9.21e-08221095GO:0007567
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.51e-07101094GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.51e-07101094GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.51e-07101094GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.51e-07101094GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.51e-07101094GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.37e-07111094GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.37e-07111094GO:0016115
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.09e-07141094GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.09e-07141094GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.63e-07151094GO:0016102
GeneOntologyBiologicalProcesstestosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.28e-06161094GO:0061370
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.28e-06161094GO:0032351
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3 CNOT1

1.64e-06381095GO:0048384
GeneOntologyBiologicalProcessneuron development

ADCY10 MYH10 B4GAT1 MAP1A NRTN RTN4R ITGA3 WDPCP NCDN TSKU MET NTNG2 IGFALS HMCN2 UBE3A CSPG4 PAK1 SLITRK5 LRP2 DIO3 KCNQ2 GPC2 ULK2

1.92e-06146310923GO:0048666
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

ADCY10 MYH10 B4GAT1 MAP1A RTN4R WDPCP TSKU MET NTNG2 IGFALS HMCN2 UBE3A PAK1 SLITRK5 LRP2 ULK2

1.96e-0674810916GO:0048667
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.13e-06181094GO:0030656
GeneOntologyBiologicalProcesspositive regulation of cytoplasmic mRNA processing body assembly

CNOT6 CNOT6L CNOT1

2.84e-0661093GO:0010606
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.12e-06211094GO:0016114
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.12e-06211094GO:0042574
GeneOntologyBiologicalProcessketone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.12e-06211094GO:0042182
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.02e-06221094GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.02e-06221094GO:0042448
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.02e-06221094GO:1902644
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.05e-06231094GO:0071379
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.05e-06231094GO:0034310
GeneOntologyBiologicalProcesscellular response to calcium ion

AKR1C4 AKR1C1 AKR1C2 RYR1 AKR1C3 KCNQ2

7.23e-06881096GO:0071277
GeneOntologyBiologicalProcessregulation of cytoplasmic mRNA processing body assembly

CNOT6 CNOT6L CNOT1

7.89e-0681093GO:0010603
GeneOntologyBiologicalProcessaxonogenesis

ADCY10 MYH10 B4GAT1 MAP1A RTN4R TSKU NTNG2 IGFALS HMCN2 PAK1 SLITRK5 LRP2 ULK2

9.18e-0656610913GO:0007409
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.01e-05261094GO:0010566
GeneOntologyBiologicalProcessicosanoid metabolic process

AKR1C4 AKR1C1 AKR1C2 CES2 DPEP2 PLA2G4B AKR1C3

1.05e-051421097GO:0006690
GeneOntologyBiologicalProcessprostaglandin metabolic process

AKR1C4 AKR1C1 AKR1C2 CES2 AKR1C3

1.16e-05561095GO:0006693
GeneOntologyBiologicalProcessneuron projection development

ADCY10 MYH10 B4GAT1 MAP1A NRTN RTN4R ITGA3 NCDN TSKU MET NTNG2 IGFALS HMCN2 UBE3A CSPG4 PAK1 SLITRK5 LRP2 GPC2 ULK2

1.17e-05128510920GO:0031175
GeneOntologyBiologicalProcessprostanoid metabolic process

AKR1C4 AKR1C1 AKR1C2 CES2 AKR1C3

1.26e-05571095GO:0006692
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.37e-05281094GO:0048025
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.58e-05291094GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.58e-05291094GO:0050686
GeneOntologyBiologicalProcessneuron projection morphogenesis

ADCY10 MYH10 B4GAT1 MAP1A RTN4R TSKU MET NTNG2 IGFALS HMCN2 UBE3A PAK1 SLITRK5 LRP2 ULK2

2.08e-0580210915GO:0048812
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.37e-05321094GO:2000353
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

ADCY10 MYH10 B4GAT1 MAP1A RTN4R TSKU MET NTNG2 IGFALS HMCN2 UBE3A PAK1 SLITRK5 LRP2 ULK2

2.65e-0581910915GO:0120039
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.68e-05331094GO:0033119
GeneOntologyBiologicalProcesscell projection morphogenesis

ADCY10 MYH10 B4GAT1 MAP1A RTN4R TSKU MET NTNG2 IGFALS HMCN2 UBE3A PAK1 SLITRK5 LRP2 ULK2

2.93e-0582610915GO:0048858
GeneOntologyBiologicalProcesssteroid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.03e-05341094GO:0006706
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.41e-05351094GO:0120255
GeneOntologyBiologicalProcessaxon development

ADCY10 MYH10 B4GAT1 MAP1A RTN4R TSKU NTNG2 IGFALS HMCN2 PAK1 SLITRK5 LRP2 ULK2

3.44e-0564210913GO:0061564
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.82e-05361094GO:0034694
GeneOntologyBiologicalProcessisoprenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.82e-05361094GO:0008299
GeneOntologyBiologicalProcessorganic hydroxy compound catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3 DIO3

4.24e-05731095GO:1901616
GeneOntologyBiologicalProcessretinoic acid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.82e-05401094GO:0042573
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

AKR1C4 AKR1C1 AKR1C2 CES2 PLA2G4B AKR1C3

6.10e-051281096GO:0033559
GeneOntologyBiologicalProcesscellular response to fatty acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.08e-05421094GO:0071398
GeneOntologyBiologicalProcessvitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 PDXK LRP2 AKR1C3

7.55e-051331096GO:0006766
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.30e-05451094GO:0008207
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

AKR1C4 AKR1C1 AKR1C2 UBE3A PAK1 AKR1C3 CNOT1

9.98e-052021097GO:0141193
GeneOntologyBiologicalProcesspositive regulation of reactive oxygen species metabolic process

ADCY10 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.10e-04891095GO:2000379
GeneOntologyBiologicalProcessretinoid metabolic process

AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3

1.10e-04891095GO:0001523
GeneOntologyBiologicalProcessalcohol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.10e-04471094GO:0046164
GeneOntologyBiologicalProcessditerpenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3

1.42e-04941095GO:0016101
GeneOntologyBiologicalProcessaldehyde metabolic process

AKR1C4 AKR1C1 AKR1C2 PDXK AKR1C3

1.49e-04951095GO:0006081
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

MYO1C LRRC24 ASIC1 RTN4R IKZF1 STIL WDPCP CNOT6 MET NTNG2 CNOT6L SSH3 VPS35 TBC1D12 PAK1 SLITRK5 CNOT1

1.63e-04118910917GO:0044087
GeneOntologyBiologicalProcesscell morphogenesis

ADCY10 MYH10 B4GAT1 MAP1A RTN4R IDUA WDPCP TSKU MET NTNG2 IGFALS HMCN2 UBE3A PAK1 SLITRK5 LRP2 ULK2

1.71e-04119410917GO:0000902
GeneOntologyBiologicalProcessresponse to calcium ion

AKR1C4 AKR1C1 AKR1C2 RYR1 AKR1C3 KCNQ2

2.15e-041611096GO:0051592
GeneOntologyBiologicalProcessketone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.35e-04571094GO:0042181
GeneOntologyBiologicalProcessP-body assembly

CNOT6 CNOT6L CNOT1

2.35e-04231093GO:0033962
GeneOntologyBiologicalProcessregulation of cell junction assembly

MYO1C LRRC24 ASIC1 RTN4R WDPCP NTNG2 VPS35 SLITRK5

2.38e-043091098GO:1901888
GeneOntologyBiologicalProcessterpenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3

2.39e-041051095GO:0006721
GeneOntologyBiologicalProcessregulation of hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.51e-04581094GO:0032350
GeneOntologyBiologicalProcesspostsynapse organization

MYH10 FNTA ASIC1 RTN4R ITGA3 NTNG2 UBE3A VPS35

2.59e-043131098GO:0099173
GeneOntologyBiologicalProcesssynapse organization

MYH10 FNTA LRRC24 ASIC1 RTN4R ITGA3 NTNG2 HMCN2 UBE3A VPS35 PAK1 SLITRK5

2.70e-0468510912GO:0050808
GeneOntologyBiologicalProcesscellular response to steroid hormone stimulus

AKR1C4 AKR1C1 AKR1C2 UBE3A PAK1 AKR1C3 CNOT1

2.81e-042391097GO:0071383
GeneOntologyBiologicalProcesspositive regulation of epithelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.87e-04601094GO:1904037
GeneOntologyBiologicalProcesshormone-mediated signaling pathway

AKR1C4 AKR1C1 AKR1C2 UBE3A PAK1 AKR1C3 CNOT1

3.18e-042441097GO:0009755
GeneOntologyBiologicalProcesshead development

MYH10 IFT172 RTN4R IKZF1 STIL AK8 TSKU MET UBE3A PAK1 SLITRK5 ANKRD11 LRP2 KCNQ2

3.44e-0491910914GO:0060322
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

DCP2 CNOT6 CNOT6L CNOT1

3.90e-04651094GO:0000288
GeneOntologyBiologicalProcessregulation of neuron projection development

ADCY10 RTN4R ITGA3 TSKU MET NTNG2 UBE3A CSPG4 PAK1 GPC2 ULK2

3.97e-0461210911GO:0010975
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

FNTA LRRC32 AKR1C4 ITGA3 AKR1C1 AKR1C2 RYR1 AKR1C3

4.16e-043361098GO:0071560
GeneOntologyBiologicalProcesssecondary metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.38e-04671094GO:0019748
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

FNTA LRRC32 AKR1C4 ITGA3 AKR1C1 AKR1C2 RYR1 AKR1C3

4.77e-043431098GO:0071559
GeneOntologyBiologicalProcessresponse to fatty acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.90e-04691094GO:0070542
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

ADCY10 RTN4R ITGA3 WDPCP TSKU MET NTNG2 UBE3A CSPG4 VPS35 PAK1 GPC2 ULK2

5.23e-0484610913GO:0120035
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

MYO1C FNTA ADAMTS3 LRRC32 AKR1C4 ITGA3 AKR1C1 AKR1C2 RYR1 MYOF UBE3A LRP2 AKR1C3

5.47e-0485010913GO:0071363
GeneOntologyBiologicalProcessneuron projection organization

ADCY10 MAP1A ITGA3 UBE3A VPS35

5.73e-041271095GO:0106027
GeneOntologyCellularComponentCCR4-NOT complex

CNOT6 CNOT6L CNOT1

7.15e-05161083GO:0030014
MousePhenoparturition failure

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.58e-0710924MP:0012010
MousePhenohypermyelination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.60e-0711924MP:0010050
MousePhenoincreased oligodendrocyte number

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.20e-0613924MP:0010160
MousePhenoincreased circulating progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.27e-0615924MP:0005186
MousePhenolong stride length

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.27e-0615924MP:0010540
MousePhenolong gestation period

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.27e-0615924MP:0002293
MousePhenoabnormal gestational length

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.01e-0618924MP:0002292
MousePhenodysmyelination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.85e-0620924MP:0013438
MousePhenodecreased oligodendrocyte number

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.00e-0525924MP:0009808
MousePhenoprolonged diestrus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.22e-0530924MP:0009011
MousePhenoabnormal parturition

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.21e-0533924MP:0002907
MousePhenoabnormal diestrus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.87e-0535924MP:0009010
MousePhenoenhanced coordination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0438924MP:0003858
MousePhenoprolonged estrous cycle

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.21e-0439924MP:0009006
MousePhenodecreased vocalization

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.32e-0446924MP:0020351
MousePhenoabnormal muscle development

MYH10 IDUA RYR1 MET MYOF

2.67e-0487925MP:0000733
MousePhenoabnormal circulating progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.21e-0450924MP:0005184
MousePhenoabnormal oligodendrocyte morphology

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.47e-0451924MP:0000953
MousePhenoincreased stereotypic behavior

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.02e-0453924MP:0001409
MousePhenoabnormal progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.32e-0454924MP:0011384
MousePhenoabnormal mitochondrial shape

RYR1 MTFMT VPS35

4.44e-0423923MP:0011633
DomainLRR_8

LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

5.20e-0817110710PF13855
DomainLeu-rich_rpt_typical-subtyp

LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

7.20e-0817710710IPR003591
DomainLRR_TYP

LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

7.20e-0817710710SM00369
DomainALDOKETO_REDUCTASE_1

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.08e-07101074PS00798
DomainAldo/ket_reductase_CS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.08e-07101074IPR018170
DomainAldo/keto_reductase

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.08e-07101074IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.08e-07101074PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.08e-07101074PS00063
DomainLRR

LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

2.37e-0720110710PS51450
DomainLRR_1

LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

5.22e-0721910710PF00560
DomainLRRNT

LRRC24 RTN4R LRRC32 TSKU IGFALS SLITRK5 LRRC15

1.50e-06981077IPR000372
DomainLRRNT

LRRC24 RTN4R LRRC32 TSKU IGFALS SLITRK5 LRRC15

1.50e-06981077SM00013
Domain-

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.76e-061610743.20.20.100
DomainNADP_OxRdtase_dom

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.29e-06171074IPR023210
DomainAldo_ket_red

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.29e-06171074PF00248
DomainAldo/ket_red/Kv-b

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.29e-06171074IPR001395
Domain-

NLRP7 LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

2.33e-06321107113.80.10.10
DomainL_dom-like

NLRP7 LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

2.86e-0632810711IPR032675
DomainLeu-rich_rpt

LRRC24 RTN4R LRRC32 LRCH1 CNOT6 TSKU IGFALS CNOT6L SLITRK5 LRRC15

3.57e-0627110710IPR001611
DomainCys-rich_flank_reg_C

LRRC24 RTN4R IGFALS SLITRK5 LRRC15

1.68e-04901075IPR000483
DomainLRRCT

LRRC24 RTN4R IGFALS SLITRK5 LRRC15

1.68e-04901075SM00082
DomainDUF3669_Znf

ZNF398 ZNF282

4.80e-0461072IPR022137
DomainDUF3669

ZNF398 ZNF282

4.80e-0461072PF12417
DomainTIL_dom

SSPOP LRP2

2.83e-03141072IPR002919
DomainARM-type_fold

WAPL HGH1 IFT172 NCDN URB1 RIC8B VPS35

3.38e-033391077IPR016024
DomainLRRNT

LRRC32 IGFALS SLITRK5

3.48e-03531073PF01462
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-079774M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-079774M47817
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3 GPC2

1.50e-0745776MM15344
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.64e-0711774M47812
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.67e-0713774M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.67e-0713774MM14747
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

FNTA AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3 GPC2

6.64e-0792777MM14881
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.90e-0714774M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.90e-0714774M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.90e-0714774M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.90e-0714774MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0615774MM14870
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C4 AKR1C1 LRP2 AKR1C3 GPC2

6.08e-0648775M27642
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.73e-0623774M1926
PathwayREACTOME_PREDNISONE_ADME

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.73e-0623774MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.73e-0623774MM14741
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.53e-0528774MM15188
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

FNTA AKR1C4 AKR1C1 LRP2 AKR1C3 GPC2

1.73e-05100776M27158
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

AKR1C4 AKR1C1 AKR1C2 DPEP2 AKR1C3

2.00e-0561775MM14861
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.99e-0533774M5967
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.99e-0533774MM14737
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

AKR1C4 AKR1C1 AKR1C2 PDXK LRP2 AKR1C3 GPC2

7.59e-05189777MM14772
PathwayREACTOME_SENSORY_PERCEPTION

FNTA AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3 GPC2

7.85e-05190777MM15687
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.46e-0544774M499
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.03e-0445774MM14751
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN

CNOT6 CNOT6L CNOT1

1.21e-0418773MM15336
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.45e-0449774MM15186
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN

CNOT6 CNOT6L CNOT1

1.94e-0421773M27634
PathwayREACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY

DCP2 CNOT6 CNOT6L CNOT1

2.12e-0454774MM15089
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.27e-0455774M14933
PathwayREACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY

DCP2 CNOT6 CNOT6L CNOT1

2.44e-0456774M839
PathwayREACTOME_DEADENYLATION_OF_MRNA

CNOT6 CNOT6L CNOT1

2.92e-0424773MM15090
PathwayKEGG_RNA_DEGRADATION

DCP2 CNOT6 CNOT6L CNOT1

2.98e-0459774M963
PathwayREACTOME_DEADENYLATION_OF_MRNA

CNOT6 CNOT6L CNOT1

3.31e-0425773M13492
PathwayREACTOME_DRUG_ADME

AKR1C4 AKR1C1 AKR1C2 CES2 AKR1C3

4.79e-04119775MM15692
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.74e-0470774M16794
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

AKR1C4 AKR1C1 PDXK LRP2 AKR1C3 GPC2

7.37e-04198776M18311
PathwayREACTOME_M_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_MATERNALLY_STORED_FACTORS

CNOT6 CNOT6L CNOT1

7.60e-0433773M48026
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CNOT6 CNOT6L CNOT1

8.30e-0434773MM15325
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

B4GAT1 ADAMTS3 SSPOP CSPG4 GPC2

1.10e-03143775M27275
PathwayREACTOME_METABOLISM_OF_STEROIDS

AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3

1.53e-03154775M27832
PathwayWP_ALTERNATIVE_PATHWAY_OF_FETAL_ANDROGEN_SYNTHESIS

AKR1C4 AKR1C2

1.57e-0311772M39749
PathwayWP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION

AKR1C1 AKR1C2 AKR1C3

1.89e-0345773M39355
PathwayREACTOME_CS_DS_DEGRADATION

IDUA CSPG4

2.21e-0313772MM14805
PathwayREACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

IDUA CSPG4 GPC2

2.27e-0348773MM14696
PathwayREACTOME_FATTY_ACID_METABOLISM

AKR1C4 AKR1C1 AKR1C2 DPEP2 AKR1C3

2.36e-03170775MM15573
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CNOT6 CNOT6L CNOT1

2.41e-0349773M27614
PathwayREACTOME_DISEASES_OF_METABOLISM

B4GAT1 ADAMTS3 IDUA SSPOP CSPG4 GPC2

2.43e-03250776M27554
PathwayREACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

IDUA CSPG4 GPC2

2.55e-0350773M678
PathwayREACTOME_CS_DS_DEGRADATION

IDUA CSPG4

2.57e-0314772M651
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110420124700
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110410500239
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110416508162
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110419487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110414967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110410393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110415193432
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110431479646
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110415222881
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110416191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110415577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110410702227
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110417034817
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110417629694
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110429764944
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110410526179
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110417888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110417442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110428329705
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110416018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110417272929
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110419237748
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110418667791
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110428259989
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110421521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-11411048274401
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110416511129
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110410803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-114110434590152
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.47e-11411047789999
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-10511047737980
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-105110421851338
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-105110417872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-105110417064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-105110410672042
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-105110438788959
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-105110416984997
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.72e-105110418003893
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.41e-096110429107092
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.41e-096110419273550
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.41e-096110415860270
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.41e-096110415471942
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.41e-096110426748576
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.41e-096110417122075
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.41e-096110417255200
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RTL6 LRRC24 ITGA3 IDUA RYR1 GRAMD2A MYOF URB1 PLA2G4B SURF6 CSPG4 DUSP16 ANKRD11 ZNF398 CPSF1 KCNQ2 GPC2 SNAPC4 ULK2

1.86e-0911051101935748872
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.29e-097110426160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.29e-097110434843575
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.29e-097110422529366
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.29e-097110433127481
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.29e-097110412562828
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.29e-097110416337335
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.57e-098110433584538
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.57e-098110420837989
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.57e-09811049224647
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.18e-089110433348080
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.96e-0810110436313771
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C1 AKR1C2 AKR1C3

3.08e-083110319320734
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C1 AKR1C2 AKR1C3

3.08e-083110331780644
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C4 AKR1C1 AKR1C3

3.08e-08311037626489
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C1 AKR1C2 AKR1C3

3.08e-083110321232532
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C1 AKR1C2 AKR1C3

3.08e-083110313678667
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.60e-0812110421256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.60e-0812110428893949
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.60e-0812110425774556
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.63e-0813110411682476
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.63e-0813110417062636
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.63e-0813110415117747
Pubmed

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.63e-0813110424580729
Pubmed

Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.25e-0814110419955443
Pubmed

Placental endocrine function shapes cerebellar development and social behavior.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.25e-0814110434400844
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.18e-0717110432243503
Pubmed

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.

CNOT6 CNOT6L CNOT1

3.06e-075110322977175
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C1 AKR1C2 AKR1C3

3.06e-075110315212687
Pubmed

Functional dynamics of H3K9 methylation during meiotic prophase progression.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.54e-0719110417599069
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

AKR1C4 AKR1C1 AKR1C2 LRP2 AKR1C3

3.98e-0747110511208732
Pubmed

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.41e-0720110423636947
Pubmed

WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.41e-0720110424135228
Pubmed

Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.

CNOT6 CNOT6L CNOT1

6.11e-076110331924127
Pubmed

Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.01e-0723110423685333
Pubmed

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

AKR1C1 AKR1C2 AKR1C3

1.07e-067110319846565
Pubmed

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.14e-0625110426098214
Pubmed

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.34e-0626110423892084
Pubmed

Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.57e-0627110417077188
Pubmed

Identification of differentially expressed genes in mouse spermatogenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.57e-0627110414581517
Pubmed

Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.57e-0627110423471215
Pubmed

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.83e-0628110429879378
Pubmed

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.83e-0628110421820362
Pubmed

The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.83e-0628110429212953
Pubmed

Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development.

CNOT6 CNOT6L CNOT1

2.55e-069110321741365
Pubmed

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.

FNTA RAD54L2 LRCH1 AKR1C2 PDXK CNOT1

2.62e-06122110630773093
Pubmed

Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.18e-0632110434288113
Pubmed

mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.

CNOT6 CNOT6L CNOT1

3.63e-0610110327618784
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.77e-0637110421362171
Pubmed

Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.

CNOT6 CNOT6L CNOT1

6.63e-0612110317452450
Pubmed

Human Ccr4-Not complexes contain variable deadenylase subunits.

CNOT6 CNOT6L CNOT1

6.63e-0612110319558367
Pubmed

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.

CNOT6 CNOT6L CNOT1

6.63e-0612110331320642
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

MYH10 B4GAT1 MYO1C RTN4R AKR1C4 IDUA AKR1C1 MYOF IGFALS KRT77 CSPG4 LRP2 AKR1C3 LRRC15

7.39e-0610701101423533145
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

WAPL AKR1C4 AKR1C1 AKR1C2 NCDN GRAMD2A URB1 CNOT6L VPS33B AMOT LRP2 AKR1C3 ULK2 CNOT1

8.56e-0610841101411544199
Pubmed

NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.

DCP2 CNOT6L CNOT1

8.60e-0613110320133598
InteractionAKR1C4 interactions

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.17e-0881074int:AKR1C4
InteractionTOP3B interactions

MYH10 RTL6 MYO1C LRRC24 ITGA3 IDUA RYR1 GRAMD2A MYOF URB1 CNOT6L PLA2G4B SURF6 CSPG4 DUSP16 ANKRD11 ZNF398 CPSF1 KCNQ2 GPC2 SNAPC4 ULK2 CNOT1

2.20e-06147010723int:TOP3B
InteractionNANOS1 interactions

CNOT6 CNOT6L PAK1 CNOT1

3.41e-06201074int:NANOS1
InteractionAKR1C1 interactions

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.41e-06201074int:AKR1C1
InteractionN4BP2 interactions

BCL3 CNOT6L AMOT VPS35 DUSP16 SNAPC4

7.91e-06891076int:N4BP2
InteractionAKR1C3 interactions

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.33e-05371074int:AKR1C3
Cytoband10p15-p14

AKR1C1 AKR1C2 AKR1C3

2.66e-076110310p15-p14
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.80e-05901104chr10p15
Cytoband7q36.1

SSPOP ZNF398 ZNF282

7.67e-047411037q36.1
CytobandEnsembl 112 genes in cytogenetic band chr9q34

AK8 NTNG2 HMCN2 SURF6 SNAPC4

1.15e-033251105chr9q34
CytobandEnsembl 112 genes in cytogenetic band chr10q23

WAPL IFIT1 MYOF TBC1D12

1.28e-031951104chr10q23
CytobandEnsembl 112 genes in cytogenetic band chr8q24

LRRC24 HGH1 LRATD2 CPSF1 FAM83A

1.69e-033551105chr8q24
GeneFamilyAldo-keto reductases

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.72e-0715704399
GeneFamilyCCR4-NOT transcription complex

CNOT6 CNOT6L CNOT1

8.97e-06117031023
CoexpressionIRITANI_MAD1_TARGETS_UP

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.46e-07171094MM826
CoexpressionVARELA_ZMPSTE24_TARGETS_DN

AKR1C4 AKR1C1 AKR1C2 IGFALS AKR1C3

1.21e-06451095MM1173
CoexpressionGSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_IRF4MID_BCELL_DN

RAD52 MYH10 MYO1C IKZF1 WDPCP NCDN CNOT6 RIC8B

1.96e-062001098M9842
CoexpressionLIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.82e-06241094MM766
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.35e-06251094MM480
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.13e-06301094MM853
CoexpressionBREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

AKR1C4 AKR1C1 AKR1C2 PLA2G4B AKR1C3

1.45e-05741095MM769
CoexpressionDESCARTES_ORGANOGENESIS_INTERMEDIATE_MESODERM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.50e-05361094MM3660
CoexpressionGSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_14H_DN

ADCY10 NLRP7 IFIT1 NCDN HMCN2 DUSP16 LRP2

1.61e-051921097M4277
CoexpressionWANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.68e-05371094MM630
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3

AKR1C4 AKR1C1 AKR1C2 CES2 AKR1C3

2.00e-05791095MM535
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN

BCL3 RAD54L2 IDUA NDUFB4 CES2 DPEP2 PLA2G4B SSH3 ANKRD11 CPSF1 CACNA1I

6.84e-0563410911M40866
CoexpressionYAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6

AKR1C4 AKR1C1 AKR1C2 CES2 AKR1C3

6.85e-051021095MM872
CoexpressionMARCHINI_TRABECTEDIN_RESISTANCE_UP

IFIT1 AKR1C1 AKR1C2

7.57e-05201093M17330
CoexpressionMIKKELSEN_MCV6_LCP_WITH_H3K4ME3

AKR1C4 CHIT1 AKR1C1 AKR1C2 CES2 AKR1C3

9.03e-051741096MM836
CoexpressionDURCHDEWALD_SKIN_CARCINOGENESIS_UP

HGH1 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-041111095MM705
CoexpressionMARSON_FOXP3_TARGETS_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.15e-04601094MM847
CoexpressionBAKKER_FOXO3_TARGETS_DN

HGH1 DCP2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.38e-041881096MM904
CoexpressionNABA_ECM_GLYCOPROTEINS

INTS6L SSPOP TSKU NTNG2 IGFALS HMCN2

1.50e-041911096MM17059
CoexpressionNADLER_HYPERGLYCEMIA_AT_OBESITY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.67e-04661094MM631
CoexpressionNABA_ECM_GLYCOPROTEINS

INTS6L SSPOP TSKU NTNG2 IGFALS HMCN2

1.73e-041961096M3008
CoexpressionGSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP

ADCY10 ASIC1 ITGA3 IDUA AKR1C1 ANKRD11

1.88e-041991096M7259
CoexpressionGSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_UP

STIL ZC3H4 SUV39H1 CPSF1 TLE6 SNAPC4

1.93e-042001096M6640
CoexpressionGSE42724_NAIVE_VS_MEMORY_BCELL_DN

DCP2 IKZF1 LRCH1 SGK3 DUSP16 PPIP5K2

1.93e-042001096M9793
CoexpressionGOLDRATH_IMMUNE_MEMORY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.99e-04691094MM621
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D

AKR1C4 AKR1C1 AKR1C2 CES2 DNAJC10 AKR1C3 LRRC15

2.29e-042931097MM895
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#1

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF NTNG2 CSPG4 DIO3 TLE6 ARHGAP20 ULK2 CCDC33

6.52e-0746210813Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K1
CoexpressionAtlasFacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_2500_k-means-cluster#3

RIPOR3 IKZF1 BCL3 GRAMD2A MYOF KRT77 CSPG4 DIO3 TLE6 ARHGAP20 ULK2 CCDC33

1.51e-0641910812Facebase_RNAseq_e9.5_Olfactory Placode_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#1

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF HMCN2 CSPG4 TLE6 ARHGAP20 ULK2 CCDC33

2.12e-0643310812Facebase_RNAseq_e10.5_Mandibular Arch_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_2500_k-means-cluster#4

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 DIO3 TLE6 GPC2 ARHGAP20 ULK2 CCDC33

2.92e-0652910813Facebase_RNAseq_e10.5_Olfactory Pit_2500_K4
CoexpressionAtlasFacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 DIO3 TLE6 GPC2 ARHGAP20 ULK2 CCDC33

2.98e-0653010813Facebase_RNAseq_e9.5_Maxillary Arch_2500_K5
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#1

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 TLE6 ARHGAP20 ULK2 CCDC33

4.11e-0638310811Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_2500_K1
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#1

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 DIO3 TLE6 ARHGAP20 ULK2 CCDC33

4.21e-0646310812Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K1
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#3

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 TLE6 ARHGAP20 ULK2 CCDC33

7.84e-0641010811Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K3
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#1

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 TLE6 ARHGAP20 ULK2 CCDC33

9.83e-0642010811Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K1
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#1

LRRC24 RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 DIO3 TLE6 ARHGAP20 ULK2 CCDC33

1.07e-0550810812Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#2

LRRC24 IKZF1 BCL3 GRAMD2A MYOF NTNG2 HMCN2 KRT77 CSPG4 TLE6 ARHGAP20 ULK2 CCDC33

1.50e-0561610813Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

RIPOR3 IKZF1 BCL3 GRAMD2A MYOF CSPG4 DIO3 TLE6 ARHGAP20 ULK2 CCDC33

1.75e-0544710811Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

RIPOR3 IKZF1 BCL3 GRAMD2A MYOF NTNG2 CSPG4 DIO3 TLE6 ARHGAP20 ULK2

2.15e-0545710811Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_2500_K4
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#4

IKZF1 BCL3 MYOF NTNG2 CSPG4 TLE6 ARHGAP20

6.51e-051961087Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_1000_K4
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#2

IKZF1 BCL3 MYOF HMCN2 CSPG4 TLE6 ARHGAP20

6.72e-051971087Facebase_RNAseq_e10.5_Mandibular Arch_1000_K2
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_1000_k-means-cluster#5

RIPOR3 IKZF1 BCL3 MYOF CSPG4 TLE6 ARHGAP20

9.17e-052071087Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_1000_K5
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_1000_k-means-cluster#1

RIPOR3 IKZF1 BCL3 MYOF CSPG4 TLE6 ARHGAP20

1.16e-042151087Facebase_RNAseq_e8.5_Paraxial Mesoderm_1000_K1
CoexpressionAtlasFacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#1

LRRC24 RIPOR3 IKZF1 BCL3 METTL21EP GRAMD2A MYOF CSPG4 DIO3 TLE6 GPC2 ARHGAP20 ULK2 CCDC33

1.45e-0487810814Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#3

IKZF1 BCL3 GRAMD2A NTNG2 HMCN2 KRT77 TLE6 ULK2 CCDC33

3.70e-044331089Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000

MYH10 WAPL IKZF1 BCL3 STIL GRAMD2A NTNG2 CNOT6L HMCN2 TTC7B KRT77 TLE6 ULK2 CCDC33

4.41e-0497910814Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000_k-means-cluster#5

IKZF1 BCL3 MYOF CSPG4 TLE6 ARHGAP20 CCDC33

5.30e-042761087Facebase_RNAseq_e10.5_Olfactory Pit_1000_K5
ToppCellRSV-Healthy-5|Healthy / Virus stimulation, Condition and Cluster

MYH10 LRRC24 LRRC32 IFIT1 LRATD2 ZNF282

6.49e-0618411061e282d619ef8035437fabe0fd2aefda1c142f7f6
ToppCellRSV-Healthy-5|RSV / Virus stimulation, Condition and Cluster

MYH10 LRRC24 LRRC32 IFIT1 LRATD2 ZNF282

6.49e-061841106ba958f731de6c9eff60103d483e020e2c0c7af7c
ToppCellNS-moderate-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CMYA5 AKR1C1 AKR1C2 MYOF AKR1C3 ARHGAP20

9.31e-06196110647930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|Epithelial / Condition, Lineage and Cell class

CMYA5 AKR1C1 AKR1C2 RYR1 TSKU FAM83A

9.58e-06197110678ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKR1C1 AKR1C2 TSKU MYOF AKR1C3 FAM83A

9.86e-0619811069718f4c013c347f1b3c785ae232dd2fb6c1fe298
Drugcloxazolam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.97e-1041094ctd:C005522
DrugPregnanes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.97e-1041094ctd:D011278
Drugtetralol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.97e-1041094ctd:C019106
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.97e-1041094ctd:C018156
DrugHydroxysteroids

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.48e-0951094ctd:D006914
Drugcresolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.48e-0951094ctd:C010092
DrugMedazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.40e-0961094ctd:D008472
DrugNitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.43e-0881094ctd:D009567
Drug4-hydroxybenzoic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.15e-0891094ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.15e-0891094ctd:D004092
Drugoctyl gallate

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-07101094ctd:C016627
Drugcyclopentanol

AKR1C1 AKR1C2 AKR1C3

1.07e-0731093ctd:C016327
Drugcyclopentanone

AKR1C1 AKR1C2 AKR1C3

1.07e-0731093ctd:C007201
Drug5-dihydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

1.07e-0731093ctd:C454687
Drug4-benzoylbenzoic acid

AKR1C1 AKR1C2 AKR1C3

1.07e-0731093ctd:C058818
Drugdichloro(4-cymene)ruthenium(II)

AKR1C1 AKR1C2 AKR1C3

1.07e-0731093ctd:C530610
DrugDihydroxydihydrobenzopyrenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.60e-07111094ctd:D004101
Drugchlordecone alcohol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.60e-07111094CID000013946
DrugPhenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.39e-07121094ctd:D020113
DrugDMBA-3,4-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.44e-07131094CID000050096
Drugflunisolide

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.44e-07131094ctd:C007734
Drugtetrahydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

4.25e-0741093ctd:C009413
Druggliquidone

AKR1C1 AKR1C2 AKR1C3

4.25e-0741093ctd:C010969
DrugDBD-H

AKR1C4 AKR1C1 AKR1C3

4.25e-0741093CID000131382
DrugBenfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A

MYO1C ASIC1 BCL3 IFIT1 RYR1 MET MYOF LRP2 ZNF282

4.39e-0719610993837_UP
Drug5-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.79e-07141094ctd:D043582
Drug1-acenaphthenol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.79e-07141094CID000022750
DrugMeclofenamic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.79e-07141094ctd:D008469
DrugNSC86000

AKR1C1 AKR1C2 AKR1C3

1.06e-0651093CID000257630
Drugoxcarbazepine

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.82e-06191094ctd:C036006
DrugAC1L93E5

AKR1C4 AKR1C1 AKR1C3

2.11e-0661093CID000412383
DrugEstazolam

AKR1C1 AKR1C2 AKR1C3

2.11e-0661093ctd:D004949
Drug3-hydroxyhexobarbital

AKR1C4 AKR1C2 AKR1C3

2.11e-0661093CID000439898
DrugGlipizide

AKR1C1 AKR1C2 AKR1C3

2.11e-0661093ctd:D005913
Drugacenaphthene-1-ol

AKR1C1 AKR1C2 AKR1C3

2.11e-0661093ctd:C023723
Drugbenzo(a)pyrene-7,8-dione

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.27e-06201094ctd:C076588
DrugChrysenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.27e-06201094ctd:D002911
DrugFlunitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.79e-06211094ctd:D005445
Drugbenzene dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.40e-06221094CID000000418
Drug4-hydroxyequilenin-o-quinone

AKR1C1 AKR1C2 AKR1C3

3.68e-0671093ctd:C117714
Drugzomepirac

AKR1C1 AKR1C2 AKR1C3

3.68e-0671093ctd:C020549
DrugFenbufen [36330-85-5]; Up 200; 15.8uM; HL60; HT_HG-U133A

B4GAT1 MYO1C AKR1C4 URB1 SSH3 PAK1 SLITRK5 LRP2

4.22e-0619310982346_UP
DrugBoldine [476-70-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

MYO1C IKZF1 NOL10 AKR1C4 IFIT1 URB1 CACNA1I SNAPC4

4.22e-0619310984122_UP
DrugFlunisolide [3385-03-3]; Down 200; 9.2uM; HL60; HT_HG-U133A

ASIC1 BCL3 URB1 SSH3 LRP2 DLX4 SNAPC4 ULK2

4.55e-0619510982168_DN
DrugGlycyrrhetinic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.91e-06241094ctd:D006034
DrugThiocolchicoside [602-41-5]; Up 200; 7uM; PC3; HT_HG-U133A

NAB2 PCDHA5 TRIM23 RYR1 TSKU URB1 CSPG4 LRRC15

5.09e-0619810985095_UP
Drug9,10-phenanthrenequinone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.82e-06251094ctd:C005399
DrugPregnanolone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.82e-06251094ctd:D011280
Drug2-cyclohexen-1-ol

AKR1C4 AKR1C2 AKR1C3

5.87e-0681093CID000013198
DrugHexestrol

AKR1C4 AKR1C1 AKR1C2 SGK3 AKR1C3

6.59e-06551095ctd:D006589
Drug1,2-dihydroxynaphthalene

AKR1C4 AKR1C1 AKR1C2 PAK1 AKR1C3

7.87e-06571095CID000011318
Drugbenzo(a)pyrene 7,8-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.42e-05311094ctd:C017228
Drugchlordecone

AKR1C4 AKR1C1 AKR1C2 TSKU AKR1C3

1.75e-05671095CID000000299
Drugalpha-methylcinnamic acid

AKR1C1 AKR1C3

2.27e-0521092ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

2.27e-0521092DB07768
Drugbaccharin

AKR1C2 AKR1C3

2.27e-0521092ctd:C012764
Drugfenamic acid

AKR1C1 AKR1C2 AKR1C3

2.28e-05121093ctd:C001209
Drugestazolam

AKR1C1 AKR1C2 TSKU AKR1C3

2.32e-05351094CID000003261
Drug5 beta-pregnane-3,20-dione

RTN4R AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.49e-05721095CID000092745
Drugquercitrin

AKR1C4 AKR1C1 AKR1C2 TSKU

2.60e-05361094CID005280459
Drug4-formyl-benzoate

AKR1C4 AKR1C1 AKR1C2

2.95e-05131093CID000012088
Drug5 alpha-androstane-3 beta,17 beta-diol

AKR1C4 NDUFB4 AKR1C1 AKR1C2 IGFALS ANKRD11 AKR1C3

3.09e-051851097CID000011301
DrugDydrogesterone

AKR1C1 AKR1C2 AKR1C3

3.74e-05141093ctd:D004394
Drug6-.beta.-Naltrexol

AKR1C4 AKR1C1 AKR1C2

3.74e-05141093CID000631219
Drug20 alpha-dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.98e-05401094CID000008956
DrugKetoprofen [22071-15-4]; Down 200; 15.8uM; PC3; HT_HG-U133A

ASIC1 IDUA URB1 SSH3 SUV39H1 LRP2 SNAPC4

4.05e-0519310974286_DN
DrugClozapine [5786-21-0]; Up 200; 12.2uM; PC3; HT_HG-U133A

NAB2 AKR1C4 NCDN URB1 PAK1 DLX4 LRRC15

4.05e-0519310974670_UP
DrugTiletamine hydrochloride; Down 200; 15.4uM; HL60; HT_HG-U133A

NOL10 NCDN MYOF SSH3 SLITRK5 SNAPC4 ULK2

4.33e-0519510973137_DN
DrugMegestrol acetate [595-33-5]; Up 200; 10.4uM; HL60; HT_HG-U133A

RAD52 AKR1C4 IFIT1 MET URB1 UBE3A DPEP2

4.33e-0519510973091_UP
DrugPimethixene maleate [13187-06-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A

ASIC1 PCDHA5 IKZF1 RAD54L2 IFIT1 MYOF CACNA1I

4.33e-0519510977468_UP
Drugo-quinone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.39e-05411094CID000011421
DrugDihydrostreptomycin sulfate [5490-27-7]; Down 200; 2.8uM; PC3; HT_HG-U133A

RAD52 ASIC1 TRIM23 MET URB1 LRP2 SNAPC4

4.47e-0519610975751_DN
DrugAlfuzosin hydrochloride [81403-68-1]; Up 200; 9.4uM; PC3; HT_HG-U133A

NOL10 BCL3 LRCH1 LRP2 CACNA1I SEC14L5 LRRC15

4.47e-0519610974644_UP
DrugNadolol [42200-33-9]; Down 200; 13uM; MCF7; HT_HG-U133A

RAD52 ASIC1 NAB2 IKZF1 IDUA MET LRP2

4.47e-0519610973359_DN
DrugAmpyrone [83-07-8]; Up 200; 19.6uM; PC3; HT_HG-U133A

B4GALNT1 IKZF1 RYR1 PDXK LRP2 ULK2 SEC14L5

4.62e-0519710974507_UP
Drugdrospirenone

AKR1C4 AKR1C1 AKR1C2

4.66e-05151093ctd:C035144
DrugTolfenamic acid [13710-19-5]; Up 200; 15.2uM; PC3; HT_HG-U133A

ASIC1 NAB2 RAD54L2 IDUA MYOF SLITRK5 LRP2

4.77e-0519810976354_UP
DrugBenzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

MAP1A ASIC1 IDUA MYOF SSH3 LRP2 SNAPC4

4.92e-0519910974294_DN
DrugNatamycin [7681-93-8]; Down 200; 6uM; HL60; HT_HG-U133A

MYO1C ASIC1 IKZF1 NCDN MYOF PAK1 SLITRK5

4.92e-0519910976126_DN
DrugLomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; HL60; HT_HG-U133A

MYO1C PDXK MYOF UBE3A SSH3 SNAPC4 SEC14L5

5.08e-0520010972348_UP
Drug9-cis-retinal

AKR1C4 AKR1C1 AKR1C3

5.71e-05161093ctd:C031390
DrugFlufenamic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.37e-05451094ctd:D005439
Drugnaphthalene-1,2-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.37e-05451094CID000000362
Drugbenzo(a)pyrene-1,6-quinone

AKR1C1 AKR1C2 AKR1C3

6.91e-05171093ctd:C030233
DrugCQ-S

B4GAT1 AKR1C2 RYR1

6.91e-05171093CID000072462
Drugcloxazolam

AKR1C1 AKR1C2 AKR1C3

8.27e-05181093CID000002816
DrugRuthenium Compounds

AKR1C1 AKR1C2 AKR1C3

8.27e-05181093ctd:D017975
Drugbenzo(a)pyrene-3,6-quinone

AKR1C1 AKR1C2 AKR1C3

8.27e-05181093ctd:C018003
DrugAC1L8ZBW

AKR1C4 AKR1C1 AKR1C2

9.78e-05191093CID000435356
Drugandrostane-3,17-dione

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.04e-04511094CID000000443
Drugcaffeic acid phenethyl ester

NRTN AKR1C4 AKR1C1 AKR1C2 CSPG4 AKR1C3 KCNQ2 LRRC15

1.27e-043111098ctd:C055494
Drug3-hydroxyandrostan-17-one

AKR1C4 NDUFB4 AKR1C1 AKR1C2 AKR1C3

1.32e-041021095CID000000225
Drugconiferaldehyde

AKR1C1 AKR1C2 AKR1C3

1.33e-04211093ctd:C075384
DrugDutasteride

AKR1C1 AKR1C2 AKR1C3

1.33e-04211093ctd:D000068538
Drugflufenamic acid

ASIC1 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.73e-041081095CID000003371
Drugphenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.73e-04581094CID000004764
DrugNSC36919

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.73e-04581094CID000235496
Drug2'-Monophosphoadenosine 5'-Diphosphoribose

AKR1C1 AKR1C2 AKR1C3

1.76e-04231093DB03461
Drugmedazepam

AKR1C1 AKR1C2 AKR1C3

2.01e-04241093CID000004041
Drug9,10-phenanthrenequinone

AKR1C4 AKR1C1 CES2 AKR1C3

2.10e-04611094CID000006763
DiseaseNeoplasms, Hormone-Dependent

AKR1C1 AKR1C2 AKR1C3

5.04e-0831103C0027661
DiseaseAmbiguous Genitalia

AKR1C1 AKR1C2 AKR1C3

5.01e-0751103C0266362
DiseasePseudohermaphroditism

AKR1C1 AKR1C2 AKR1C3

5.01e-0751103C0033804
DiseaseHermaphroditism

AKR1C1 AKR1C2 AKR1C3

5.01e-0751103C0019269
DiseaseIntersex Conditions

AKR1C1 AKR1C2 AKR1C3

5.01e-0751103C2930618
DiseaseSex Differentiation Disorders

AKR1C1 AKR1C2 AKR1C3

5.01e-0751103C2930619
DiseaseDisorders of Sex Development

AKR1C1 AKR1C2 AKR1C3

1.75e-0671103C0036875
DiseaseMALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE

AKR1C4 AKR1C2

1.38e-0521102C1839840
Disease46,XY SEX REVERSAL 8

AKR1C4 AKR1C2

1.38e-0521102614279
Disease46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

AKR1C4 AKR1C2

1.38e-0521102cv:C1839840
Disease46,XY sex reversal 8 (is_implicated_in)

AKR1C4 AKR1C2

1.38e-0521102DOID:0111773 (is_implicated_in)
Diseasecortolone glucuronide (1) measurement

AKR1C2 AKR1C3

2.05e-0461102EFO_0800552
Diseaseheart disease (implicated_via_orthology)

CNOT6 CNOT6L CNOT1

3.87e-04381103DOID:114 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

ZC3H4 PAK1 ANKRD11 KCNQ2

4.14e-04931104C1535926
DiseaseB-lymphoblastic leukemia/lymphoma (is_implicated_in)

IKZF1 AKR1C3

6.08e-04101102DOID:0080630 (is_implicated_in)
DiseaseMetabolic Bone Disorder

ANKRD11 LRP2

1.22e-03141102C0005944
Diseaseunipolar depression, cognitive function measurement

MYH10 SGK3

1.40e-03151102EFO_0003761, EFO_0008354
DiseaseOsteopenia

ANKRD11 LRP2

1.40e-03151102C0029453
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

1.60e-03161102GO_0031427
DiseaseSchizophrenia

ADAMTS3 RTN4R CMYA5 MET NTNG2 PLA2G4B VPS35 LRP2 DIO3 KCNQ2

1.74e-0388311010C0036341
DiseaseNeoplastic Cell Transformation

AKR1C1 AKR1C2 SUV39H1 AKR1C3

1.85e-031391104C0007621
Diseasefree androgen index

AKR1C4 AKR1C2 MET URB1 AKR1C3 PPIP5K2

2.82e-033741106EFO_0007005
DiseaseN-glycan measurement

NRTN IKZF1

3.03e-03221102EFO_0004999
Diseaseschizophrenia (is_implicated_in)

RTN4R PAK1 CACNA1I

3.13e-03781103DOID:5419 (is_implicated_in)
DiseaseEndometrioma

IFIT1 AKR1C1 AKR1C2 AKR1C3

3.15e-031611104C0269102
DiseaseEndometriosis

IFIT1 AKR1C1 AKR1C2 AKR1C3

3.15e-031611104C0014175
DiseaseEpilepsy, Cryptogenic

UBE3A ANKRD11 KCNQ2

3.60e-03821103C0086237
DiseaseAwakening Epilepsy

UBE3A ANKRD11 KCNQ2

3.60e-03821103C0751111
DiseaseAura

UBE3A ANKRD11 KCNQ2

3.60e-03821103C0236018

Protein segments in the cluster

PeptideGeneStartEntry
PRQLLQRYLAAAGEQ

TBC1D12

66

O60347
TPALIALRYQLQRGV

AKR1C4

251

P17516
GPYQEARRQLSLLLD

ADAD2

551

Q8NCV1
QRLLQEQLRYGNPSE

AMOT

16

Q4VCS5
RAGYPLSERQQVALL

ANKRD11

106

Q6UB99
QLLLYRVVRGPQLGR

CSPG4

1616

Q6UVK1
GRYALRLSAENPLQV

CCDC33

41

Q8N5R6
SYPNNLLRNLAREGA

B4GAT1

206

O43505
PGLDQLNRQLQLVTY

B4GALNT1

211

Q00973
TPALIALRYQLQRGV

AKR1C3

251

P42330
QLLQRLYDPVQGQVL

ABCB5

1061

Q2M3G0
LRELVLAGNRLAYLQ

IGFALS

196

P35858
RINDQLARLYIIPGI

DCP2

166

Q8IU60
RRVVLTGYPLQNNLI

RAD54L2

486

Q9Y4B4
LLLNSRYPQLIQVLG

ADCY10

1346

Q96PN6
YLALPERAQLAAQLG

DLX4

141

Q92988
LLQQLRELPGQLASY

ABHD16B

86

Q9H3Z7
YQAIQKALRQRLGPE

RAD52

36

P43351
NAYDIPRRGLLDQLT

INTS6L

511

Q5JSJ4
IARLAQYRALLQGAP

NRTN

51

Q99748
NQGRYPLIQTLRQEL

CHIT1

371

Q13231
LNRLGIQAEPLYRVV

MAP1A

166

P78559
LNQAEGRNPTLERYL

NCDN

26

Q9UBB6
LPRTLGELQLYRVLQ

NAB2

36

Q15742
GELQLYRVLQRANLL

NAB2

41

Q15742
RQVLGARGYSLNLIP

GPC2

36

Q8N158
ILDYAQGNRPLVLNF

DIO3

151

P55073
RLQQGAYRLLPSNAL

HMCN2

3801

Q8NDA2
NRQGELRISVLPAYL

CPSF1

991

Q10570
QAHLLNRLGYNPNRV

AK8

361

Q96MA6
QTERQQRYLLLAGAP

ITGA3

61

P26006
KLQNFLYNVLERPRG

KCNQ2

76

O43526
QYLQLNLQPAVGRAL

CES2

516

O00748
LAQLRVLYLAGNQLA

LRRC24

121

Q50LG9
LNVRRNYLKVLPQEL

LRCH1

216

Q9Y2L9
LRIGKQPYRLQIQLS

LRATD2

221

Q96KN1
LGAYRPTRLQLEQLG

FAM83A

401

Q86UY5
VLRDNVPNLRGLQVY

LRP2

1996

P98164
LPELLGNLQYNISRN

METTL21EP

146

A6NDL7
LGVLAPSQLQRYRQE

PLA2G4B

371

P0C869
NNAINYLGAESLRPL

IKZF1

316

Q13422
LNLEQGRYLNPLQTD

NOL10

161

Q9BSC4
IGANAQLRYRLNPNE

PCDHA5

161

Q9Y5H7
EYLLQYNDPNRRGLI

NDUFB4

46

O95168
ILTPLGRYQIINGLR

SMPD4

706

Q9NXE4
GLLLRAQRPGLALNY

IFT172

1221

Q9UG01
LAALPRLIYLNLSNN

LRRC32

261

Q14392
RLIYLNLSNNLIRLP

LRRC32

266

Q14392
GRPLSQLLNLDLSYN

LRRC32

311

Q14392
NENPLRALYLIATNG

PAK1

466

Q13153
RANLLLLGYAQGRLE

WDPCP

261

O95876
YQLRTVRCLQPLLDG

ADAMTS3

926

O15072
LYQALQSRRQALGPE

CACNA1I

456

Q9P0X4
PARVGILLDYNNQRL

CMYA5

4006

Q8N3K9
RILPNLYLGCQRDVL

DUSP16

161

Q9BY84
IFRLYRAIGNIIPLQ

MTFMT

261

Q96DP5
GYLDLLRENQLLPGF

IDUA

116

P35475
LRQAVRLNPDNGYIK

IFIT1

206

P09914
DLPLVLRQVYQKGLQ

DPEP2

91

Q9H4A9
LLPELRRASNLLYGQ

DNAJC10

486

Q8IXB1
QRDFLLQGRLYISPN

GRAMD2A

96

Q8IUY3
GGRELDIYNNLRQTP

BCL3

161

P20749
QDIDGRPLYILRLGQ

SEC14L5

321

O43304
PGRELLLQTNLINYV

RYR1

626

P21817
RAGLNEFIQNLVRYP

SGK3

91

Q96BR1
ILNLYQEPDGTRRLL

CNOT6

136

Q9ULM6
IRALELDPNLYRIGQ

MYH10

751

P35580
PGRQQVRDQGAYLIL

HGH1

301

Q9BTY7
LLRPALGGTYVQREN

NTNG2

256

Q96CW9
DITVYLLQGRRLLQP

MET

1291

P08581
QLPRANVVLLRYLFG

ARHGAP20

476

Q9P2F6
QPRSLLLQAARGYVV

MRPS15

41

P82914
PLRNNYQGFLAELRR

RTL6

161

Q6ICC9
LAPLRALQYLRLNDN

RTN4R

246

Q9BZR6
RPHYLQLDLLQPRNL

SSPOP

2121

A2VEC9
LGNLQVLRLYENRLT

LRRC15

196

Q8TF66
QLRYELQGLPLLTQI

RIC8B

181

Q9NVN3
DRGLSKYPNLLNQLL

FNTA

286

P49354
GRLLESLGQLYRNLN

SH3TC2

1001

Q8TF17
LRDLQLLAQQPIYVR

NLRP7

306

Q8WX94
GNLTPLTGRNYRQLL

SURF6

226

O75683
PILQNIGQLGLLARY

URB1

1061

O60287
SNYLIVLGSQRRRNP

PDXK

196

O00764
NDQGQVRLRAGLPIY

SUV39H1

206

O43463
ELRLGLPLQQYRDFI

SSH3

301

Q8TE77
TPALIALRYQLQRGV

AKR1C1

251

Q04828
TPALIALRYQLQRGV

AKR1C2

251

P52895
AGELLALLNNRYEIP

ASIC1

111

P78348
NNLLRVLPYELGRLF

CNOT6L

111

Q96LI5
PGNRYNLQLINALVL

CNOT1

2206

A5YKK6
YLLNQNLRSIPEQLG

STIL

1151

Q15468
GLYGRLLQIERFPQA

TEX13D

141

A0A0J9YY54
GQQLNPYLRLKVRRD

UBE3A

516

Q05086
QPQLRELEYQVLGFR

RIPOR3

531

Q96MK2
LLLSGNLLNRLYPNE

SLITRK5

86

O94991
QHPLRGLFLRNYLLQ

VPS35

141

Q96QK1
YGLLQRRLENLENLL

ZNF398

106

Q8TD17
YLPQEQRFDIRVLGL

WAPL

971

Q7Z5K2
YRQLALNAPGENILF

SERPINA13P

61

Q6UXR4
FLPSAQRALYLRIQQ

ZC3H4

761

Q9UPT8
YKNPRNNLRSLLGER

ZNF844

56

Q08AG5
SPYLANLLLGLLQRN

ULK2

241

Q8IYT8
IPEALGYVRQALQLQ

TTC7B

531

Q86TV6
VRGQLQDNPAYLLLR

SNAPC4

1351

Q5SXM2
LQAEGILLPRYAILN

PPIP5K2

141

O43314
LELLERLQNGPIGQY

TRIM23

96

P36406
NLRDLPLRYLSLDGN

TSKU

201

Q8WUA8
LARDQLIYLLEQLPG

VPS33B

21

Q9H267
YGLLQRRLENLENLL

ZNF282

161

Q9UDV7
LNYQGILNRLKQFPR

TLE6

31

Q9H808
LEPLLENYIGDLRRQ

KRT77

211

Q7Z794
TLRRLGLERNPQSYL

MYO1C

251

O00159
RIYIVRGLELQPQDN

MYOF

1556

Q9NZM1