Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF771 ZNF696 MXD3 IRF4 ZSCAN12 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	1.71e-10	1459	37	17	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF771 MXD3 IRF4 ZSCAN12 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	1.73e-10	1244	37	16	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF771 MXD3 IRF4 ZSCAN12 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	2.38e-10	1271	37	16	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF771 ZNF696 MXD3 IRF4 ZSCAN12 ZNF317 ZNF154 ZNF157 ZNF418 MTF1 ZSCAN5A ZNF423 ZSCAN5C ZNF316 ZNF304	1.09e-08	1412	37	15	GO:0000981
MousePheno	increased Schwann cell number	HSPG2 DHTKD1	4.97e-05	6	26	2	MP:0010742
MousePheno	increased chromosomal stability	ZSCAN5A ZSCAN5C	4.97e-05	6	26	2	MP:0010095
Domain	zf-C2H2	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	9.28e-12	693	35	14	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	9.46e-12	694	35	14	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	4.12e-11	775	35	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	4.26e-11	777	35	14	PS00028
Domain	Znf_C2H2-like	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	5.87e-11	796	35	14	IPR015880
Domain	Znf_C2H2	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	6.82e-11	805	35	14	IPR007087
Domain	ZnF_C2H2	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	7.16e-11	808	35	14	SM00355
Domain	-	ZNF771 ZNF696 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 MTF1 ZSCAN5A ZNF691 ZNF423 ZNF316 ZNF304	1.22e-10	679	35	13	3.30.160.60
Domain	zf-C2H2_6	ZNF771 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 ZNF423 ZNF316	9.26e-08	314	35	8	PF13912
Domain	KRAB	ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 ZNF316 ZNF304	3.80e-06	358	35	7	PS50805
Domain	KRAB	ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 ZNF316 ZNF304	3.80e-06	358	35	7	PF01352
Domain	KRAB	ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 ZNF316 ZNF304	4.63e-06	369	35	7	SM00349
Domain	KRAB	ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 ZNF316 ZNF304	4.72e-06	370	35	7	IPR001909
Domain	LDLR_class-A_CS	LRP4 HSPG2	2.54e-03	40	35	2	IPR023415
Domain	Ldl_recept_a	LRP4 HSPG2	3.21e-03	45	35	2	PF00057
Domain	-	LRP4 HSPG2	3.35e-03	46	35	2	4.10.400.10
Domain	LDLRA_1	LRP4 HSPG2	3.65e-03	48	35	2	PS01209
Domain	LDrepeatLR_classA_rpt	LRP4 HSPG2	3.80e-03	49	35	2	IPR002172
Domain	LDLa	LRP4 HSPG2	3.80e-03	49	35	2	SM00192
Domain	LDLRA_2	LRP4 HSPG2	3.80e-03	49	35	2	PS50068
Domain	SCAN	ZSCAN5A ZSCAN5C	4.93e-03	56	35	2	SM00431
Domain	SCAN_BOX	ZSCAN5A ZSCAN5C	5.28e-03	58	35	2	PS50804
Domain	SCAN	ZSCAN5A ZSCAN5C	5.28e-03	58	35	2	PF02023
Domain	SCAN_dom	ZSCAN5A ZSCAN5C	5.28e-03	58	35	2	IPR003309
Domain	Retrov_capsid_C	ZSCAN5A ZSCAN5C	5.46e-03	59	35	2	IPR008916
Pubmed	Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.	ZSCAN5A ZSCAN5C	6.60e-06	4	37	2	31155506
Pubmed	ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.	ZSCAN5A ZSCAN5C	6.60e-06	4	37	2	27732952
Pubmed	Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue.	SCNN1D PKD1L3	1.65e-05	6	37	2	19812697
Pubmed	Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.	MXD3 MTF1	8.53e-05	13	37	2	16093251
Pubmed	Genetic predictors of fibrin D-dimer levels in healthy adults.	LRP4 ARHGEF28	1.31e-04	16	37	2	21502573
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MXD3 ZSCAN12 MTF1 ZSCAN5A ZNF423 ZSCAN5C	1.94e-04	808	37	6	20412781
Pubmed	Congenital Myasthenic Syndromes Overview	LRP4 ALG2	3.52e-04	26	37	2	20301347
Pubmed	CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.	IRF4 ADAMTS5 ZNF423	5.07e-04	146	37	3	29688375
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	ZSCAN5A ZSCAN5C	5.35e-04	32	37	2	38060382
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	LRP4 FZD3	6.41e-04	35	37	2	30940800
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	HSPG2 ADAMTS5	7.56e-04	38	37	2	29743679
Pubmed	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.	HSPG2 ADAMTS5	7.56e-04	38	37	2	18267097
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF317 ZNF649 ZNF316	9.46e-04	181	37	3	37372979
Cytoband	19q13.43	ZNF418 ZSCAN5A ZSCAN5C	4.87e-05	87	37	3	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF154 ZNF649 ZNF418 ZSCAN5A ZSCAN5C ZNF304	3.53e-04	1192	37	6	chr19q13
Cytoband	19q13.4	ZNF154 ZNF304	1.87e-03	79	37	2	19q13.4
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF771 ZNF696 ZSCAN12 ZNF317 ZNF154 ZNF157 ZNF649 ZNF418 ZSCAN5A ZNF691 ZNF423 ZSCAN5C ZNF316 ZNF304	5.13e-13	718	28	14	28
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSL1 HSPG2	2.56e-02	161	28	2	593
Drug	Proadifen hydrochloride [62-68-0]; Down 200; 10.2uM; HL60; HT_HG-U133A	ZNF771 MXD3 ADAMTS5 PDE12 CHRNA9	1.53e-05	195	37	5	2707_DN
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; PC3; HT_HG-U133A	OBSL1 LRP4 IRF4 ADAMTS5 FSHB	1.57e-05	196	37	5	4443_UP
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	MXD3 HSPG2 ADAMTS5 ARHGEF28 CHRNA9	1.60e-05	197	37	5	5202_UP
Disease	Myasthenic Syndromes, Congenital, Slow Channel	LRP4 ALG2	1.53e-04	16	34	2	C0751885
Disease	Congenital Myasthenic Syndromes, Postsynaptic	LRP4 ALG2	1.73e-04	17	34	2	C0751883
Disease	Congenital Myasthenic Syndromes, Presynaptic	LRP4 ALG2	2.18e-04	19	34	2	C0751884
Disease	Myasthenic Syndromes, Congenital	LRP4 ALG2	3.50e-04	24	34	2	C0751882
Disease	D dimer measurement	LRP4 ARHGEF28	5.49e-04	30	34	2	EFO_0004507
Disease	Disproportionate short stature	OBSL1 HSPG2	3.57e-03	77	34	2	C0878659

Protein segments in the cluster

Peptide	Gene	Start	Entry
HRSHCFYRGTVDGSP	ADAMTS5	126	Q9UNA0
VYDVGESCLSPHHSR	CHRNA9	351	Q9UGM1
YDGAGPDHSSCRIER	DHTKD1	701	Q96HY7
HHVSPADSGEYVCRV	HSPG2	2781	P98160
KCEPGSSREHDHDYS	KRT26	121	Q7Z3Y9
SEGEGHSEPSHICYT	ARHGEF28	486	Q8N1W1
DQGTYGCESHHDRTL	OBSL1	1516	O75147
REREAEHGYASLCPH	MXD3	21	Q9BW11
PEGCRISHGHTYDAS	IRF4	271	Q15306
EAGPGTCTFDHRHLY	PDE12	271	Q6L8Q7
YETVRVPGCAHHADS	FSHB	76	P01225
TDSCYFHSGPRGTHD	GBE1	306	Q04446
HGSLHRSRDGRYTPC	FZD3	586	Q9NPG1
EDEVHRLGSPYGHCT	SCNN1D	521	P51172
PSRVHVGSGDHDYCV	PPRC1	1286	Q5VV67
VGSGDHDYCVRSRTP	PPRC1	1291	Q5VV67
STHHGSRGEERPYCE	CLIP1	1406	P30622
RTHTGEKPFRCDHDG	MTF1	251	Q14872
REVCEHTYYSAHPGG	OVCH1	726	Q7RTY7
TLYGSEGRSEPHHLC	PKD1L3	766	Q7Z443
TAHYDPGHCFAESRE	ALG2	51	Q9H553
RPEELESGGMYHCHS	SLC30A8	41	Q8IWU4
HTRTHTGERPYECTE	ZNF157	236	P51786
HARTHTGERPFGCTE	ZNF771	81	Q7L3S4
HRTHTGERPYECTEC	ZNF691	246	Q5VV52
RLPFHGYESACSGRH	SMRP1	191	Q8NCR6
FHQRTHTGERPYTCD	ZSCAN5A	401	Q9BUG6
HQRAHSGERPYACAE	ZNF696	171	Q9H7X3
TAHGRAHTGERPYAC	ZNF316	791	A6NFI3
HQRGHTGERPYECGE	ZNF418	416	Q8TF45
PCHGSHYDASGRIRL	UQCRFS1P1	246	P0C7P4
HQRFHTGERPYECSE	ZNF304	381	Q9HCX3
QHRGVHTGERPYECS	ZNF154	346	Q13106
EGVYCHLDSHRQPDS	ZNF423	336	Q2M1K9
HTEHQRICPGEESYG	ZSCAN12	261	O43309
RTHTGERPYECHDCG	ZNF317	326	Q96PQ6
FHQRTHTGERPYTCD	ZSCAN5C	401	A6NGD5
HRTHTGERPYGCDEC	ZNF649	421	Q9BS31
HTGYRLTEDGHTCQD	LRP4	381	O75096