Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchromatin binding

MKRN4P VAX1 RNF2 PHF19 MKRN1 PPP2R3B NSD1 CDT1 PHF10 POLR3A DNMT1

1.28e-057396111GO:0003682
GeneOntologyMolecularFunctionhistone modifying activity

MED24 KMT2C KMT2D RNF2 NSD1 PHF10

6.99e-05229616GO:0140993
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

MKRN3 MKRN4P MED24 TRAF6 RNF2 MYCBP2 MKRN1 HERC1

9.15e-05473618GO:0004842
GeneOntologyMolecularFunctionacyltransferase activity

MKRN3 MKRN4P MED24 KMT2C TRAF6 RNF2 MYCBP2 MKRN1 HERC1 PHF10

1.10e-047756110GO:0016746
GeneOntologyMolecularFunctionubiquitin protein ligase activity

MKRN3 MKRN4P MED24 TRAF6 RNF2 MYCBP2 MKRN1

1.35e-04372617GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

MKRN3 MKRN4P MED24 TRAF6 RNF2 MYCBP2 MKRN1 HERC1

1.58e-04512618GO:0019787
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

MKRN3 MKRN4P MED24 TRAF6 RNF2 MYCBP2 MKRN1

2.05e-04398617GO:0061659
GeneOntologyMolecularFunctionaminoacyltransferase activity

MKRN3 MKRN4P MED24 TRAF6 RNF2 MYCBP2 MKRN1 HERC1

2.05e-04532618GO:0016755
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2D

2.54e-048612GO:0140945
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2C KMT2D NSD1

3.29e-0444613GO:0140938
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2D

4.07e-0410612GO:0140999
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2C KMT2D NSD1

1.18e-0368613GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2C KMT2D NSD1

1.23e-0369613GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2C KMT2D NSD1

1.34e-0371613GO:0042054
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH5 DNAH9

1.36e-0318612GO:0008569
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2D

1.68e-0320612GO:0042800
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

KMT2C KMT2D NSD1 DNMT1

1.89e-03172614GO:0008757
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH5 DNAH9

3.30e-0328612GO:0051959
GeneOntologyMolecularFunctionprotein methyltransferase activity

KMT2C KMT2D NSD1

3.86e-03103613GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

KMT2C KMT2D NSD1

4.08e-03105613GO:0008170
GeneOntologyMolecularFunctionmethyltransferase activity

KMT2C KMT2D NSD1 DNMT1

4.09e-03213614GO:0008168
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2C KMT2D RNF2 PHF19 NSD1

2.24e-0675595GO:0035097
GeneOntologyCellularComponentmethyltransferase complex

KMT2C KMT2D RNF2 PHF19 NSD1

1.34e-05108595GO:0034708
GeneOntologyCellularComponentMLL3/4 complex

KMT2C KMT2D

5.08e-0412592GO:0044666
GeneOntologyCellularComponentouter dynein arm

DNAH5 DNAH9

5.08e-0412592GO:0036157
GeneOntologyCellularComponentmicrofibril

FBN2 FBN3

5.99e-0413592GO:0001527
GeneOntologyCellularComponentnuclear protein-containing complex

MED24 KMT2C KMT2D RNF2 PHF19 ZCCHC8 EXOSC3 NSD1 MCM6 PHF10 POLR3A

1.45e-0313775911GO:0140513
DomainRING

MKRN3 MKRN4P KMT2C TRAF6 KMT2D RAPSN RNF2 MYCBP2 MKRN1 NSD1

5.03e-083056110SM00184
DomainZnf_RING

MKRN3 MKRN4P KMT2C TRAF6 KMT2D RAPSN RNF2 MYCBP2 MKRN1 NSD1

9.37e-083266110IPR001841
Domain-

MKRN3 KMT2C TRAF6 KMT2D RAPSN RNF2 PHF19 MYCBP2 MKRN1 NSD1 PHF10

1.94e-0744961113.30.40.10
DomainZnf_RING/FYVE/PHD

MKRN3 KMT2C TRAF6 KMT2D RAPSN RNF2 PHF19 MYCBP2 MKRN1 NSD1 PHF10

2.42e-074596111IPR013083
DomainZF_RING_2

MKRN3 MKRN4P KMT2C TRAF6 KMT2D RAPSN RNF2 MYCBP2 MKRN1

4.98e-07298619PS50089
DomainZF_RING_1

MKRN3 MKRN4P TRAF6 KMT2D RAPSN RNF2 MYCBP2 MKRN1

4.54e-06291618PS00518
DomainPHD

KMT2C KMT2D PHF19 NSD1 PHF10

4.55e-0675615PF00628
DomainZnf_PHD-finger

KMT2C KMT2D PHF19 NSD1 PHF10

5.89e-0679615IPR019787
DomainMKRN1_C

MKRN3 MKRN1

1.05e-052612PF15815
DomainMKRN1_C

MKRN3 MKRN1

1.05e-052612IPR031644
DomainPHD

KMT2C KMT2D PHF19 NSD1 PHF10

1.06e-0589615SM00249
DomainZnf_PHD

KMT2C KMT2D PHF19 NSD1 PHF10

1.18e-0591615IPR001965
DomainZF_PHD_2

KMT2C KMT2D PHF19 NSD1 PHF10

1.45e-0595615PS50016
DomainZF_PHD_1

KMT2C KMT2D PHF19 NSD1 PHF10

1.53e-0596615PS01359
DomainPost-SET_dom

KMT2C KMT2D NSD1

1.80e-0516613IPR003616
DomainPostSET

KMT2C KMT2D NSD1

1.80e-0516613SM00508
DomainPOST_SET

KMT2C KMT2D NSD1

1.80e-0516613PS50868
DomainFBN

FBN2 FBN3

3.14e-053612IPR011398
Domainzf-C3HC4

MKRN3 MKRN4P TRAF6 RAPSN RNF2 MKRN1

8.70e-05223616PF00097
DomainFYrich_C

KMT2C KMT2D

1.04e-045612IPR003889
DomainFYrich_N

KMT2C KMT2D

1.04e-045612IPR003888
DomainFYRC

KMT2C KMT2D

1.04e-045612SM00542
DomainFYRN

KMT2C KMT2D

1.04e-045612SM00541
DomainFYRN

KMT2C KMT2D

1.04e-045612PF05964
DomainFYRC

KMT2C KMT2D

1.04e-045612PF05965
DomainFYRC

KMT2C KMT2D

1.04e-045612PS51543
DomainFYRN

KMT2C KMT2D

1.04e-045612PS51542
DomainZnf_FYVE_PHD

KMT2C KMT2D PHF19 NSD1 PHF10

1.18e-04147615IPR011011
DomainTB

FBN2 FBN3

2.18e-047612PF00683
DomainDHC_N1

DNAH5 DNAH9

2.90e-048612PF08385
Domain-

FBN2 FBN3

2.90e-0486123.90.290.10
DomainDynein_heavy_dom-1

DNAH5 DNAH9

2.90e-048612IPR013594
DomainSET

KMT2C KMT2D NSD1

3.23e-0441613PF00856
DomainTB

FBN2 FBN3

3.72e-049612PS51364
DomainTB_dom

FBN2 FBN3

3.72e-049612IPR017878
DomainSET

KMT2C KMT2D NSD1

4.55e-0446613SM00317
DomainZnF_C3H1

MKRN3 MKRN4P MKRN1

5.16e-0448613SM00356
Domainzf-CCCH

MKRN3 MKRN4P MKRN1

5.49e-0449613PF00642
DomainSET_dom

KMT2C KMT2D NSD1

5.82e-0450613IPR001214
DomainSET

KMT2C KMT2D NSD1

5.82e-0450613PS50280
DomainHMG_box

KMT2C KMT2D SOX13

6.91e-0453613PF00505
DomainHMG

KMT2C KMT2D SOX13

7.30e-0454613SM00398
DomainZnf_CCCH

MKRN3 MKRN4P MKRN1

9.00e-0458613IPR000571
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH9

9.31e-0414612IPR024317
DomainDynein_HC_stalk

DNAH5 DNAH9

9.31e-0414612IPR024743
DomainDynein_heavy_dom-2

DNAH5 DNAH9

9.31e-0414612IPR013602
DomainDHC_N2

DNAH5 DNAH9

9.31e-0414612PF08393
DomainMT

DNAH5 DNAH9

9.31e-0414612PF12777
DomainAAA_8

DNAH5 DNAH9

9.31e-0414612PF12780
DomainATPase_dyneun-rel_AAA

DNAH5 DNAH9

9.31e-0414612IPR011704
DomainAAA_5

DNAH5 DNAH9

9.31e-0414612PF07728
DomainDHC_fam

DNAH5 DNAH9

1.07e-0315612IPR026983
DomainDynein_heavy_dom

DNAH5 DNAH9

1.07e-0315612IPR004273
DomainDynein_heavy

DNAH5 DNAH9

1.07e-0315612PF03028
DomainHMG_box_dom

KMT2C KMT2D SOX13

1.25e-0365613IPR009071
DomainRCC1

MYCBP2 HERC1

1.92e-0320612PF00415
DomainZnf_RING_CS

MKRN3 TRAF6 RNF2 MKRN1

1.98e-03163614IPR017907
DomainRCC1_1

MYCBP2 HERC1

2.12e-0321612PS00625
DomainRCC1_2

MYCBP2 HERC1

2.12e-0321612PS00626
DomainRCC1_3

MYCBP2 HERC1

2.12e-0321612PS50012
DomainEPHD

KMT2C KMT2D

2.32e-0322612PS51805
DomainReg_chr_condens

MYCBP2 HERC1

2.32e-0322612IPR000408
Domain-

MYCBP2 HERC1

2.32e-03226122.130.10.30
DomainZnf_C3HC4_RING-type

MKRN3 TRAF6 RNF2 MKRN1

2.41e-03172614IPR018957
DomainRCC1/BLIP-II

MYCBP2 HERC1

2.54e-0323612IPR009091
DomaincEGF

FBN2 FBN3

3.24e-0326612IPR026823
DomaincEGF

FBN2 FBN3

3.24e-0326612PF12662
DomainhEGF

FBN2 FBN3

3.76e-0328612PF12661
Pubmed

Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.

MKRN4P MKRN1 PPP2R3B NSD1

6.37e-10862415522233
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

3.13e-06262228483418
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

3.13e-06262234156443
Pubmed

Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.

MCM6 CDT1

3.13e-06262220202939
Pubmed

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation.

MKRN4P MKRN1

3.13e-06262230143610
Pubmed

An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.

MKRN4P MKRN1

3.13e-06262212721631
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

3.13e-06262231924266
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

3.13e-06262227280393
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

3.13e-06262236869380
Pubmed

Down-regulation of salt-inducible kinase 1 (SIK1) is mediated by RNF2 in hepatocarcinogenesis.

RNF2 SIK1

3.13e-06262227911266
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

3.13e-06262228967912
Pubmed

Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma.

MKRN4P MKRN1

3.13e-06262219604354
Pubmed

The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans.

MKRN4P MKRN1

3.13e-06262216882727
Pubmed

The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells.

MCM6 CDT1

3.13e-06262221099365
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

3.13e-06262225346535
Pubmed

Structural insights into the Cdt1-mediated MCM2-7 chromatin loading.

MCM6 CDT1

3.13e-06262222140117
Pubmed

Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals.

MKRN4P MKRN1

3.13e-06262216415359
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

3.13e-06262236601880
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

MED24 KMT2D RNF2 ZCCHC8 MCM6 UTRN PHF10

8.46e-0641062726949251
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

KMT2D RNF2 PHF19 PHF10 DNMT1

9.25e-0615762530186101
Pubmed

Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord.

C3 ST8SIA1

9.37e-06362224673754
Pubmed

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.

MCM6 CDT1

9.37e-06362215811859
Pubmed

Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF.

MKRN4P MKRN1

9.37e-06362223104211
Pubmed

Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia.

DNAH5 DNAH9

9.37e-06362215750039
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2C KMT2D

9.37e-06362223932714
Pubmed

DNA methyltransferase DNMT1 inhibits lipopolysaccharide‑induced inflammatory response in human dental pulp cells involving the methylation changes of IL‑6 and TRAF6.

TRAF6 DNMT1

9.37e-06362231974603
Pubmed

The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.

PPP2R3B CDT1

9.37e-06362227974665
Pubmed

Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues.

C3 ST8SIA1

9.37e-06362220018737
Pubmed

The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.

MKRN4P MKRN1

9.37e-06362210843807
Pubmed

Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.

DNAH5 DNAH9

9.37e-06362215845866
Pubmed

Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.

MKRN4P MKRN1

9.37e-06362224336050
Pubmed

Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.

KMT2C KMT2D

9.37e-06362222183980
Pubmed

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin.

MCM6 CDT1

9.37e-06362215286659
Pubmed

Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity.

MCM6 CDT1

9.37e-06362212192004
Pubmed

DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability.

TRAF6 DNMT1

9.37e-06362235804015
Pubmed

Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.

PDE4D SIK1

9.37e-06362225918234
Pubmed

HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.

KMT2C KMT2D

9.37e-06362221683083
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

MED24 KMT2C KMT2D RNF2 ZCCHC8

1.25e-0516762520362541
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2C KMT2D

1.87e-05462219221051
Pubmed

Cancer gene mutation frequencies for the U.S. population.

KMT2C KMT2D

1.87e-05462234645806
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C KMT2D

1.87e-05462228398509
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN2 FBN3

1.87e-05462225034023
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2C KMT2D

1.87e-05462223129768
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2C KMT2D

1.87e-05462224081332
Pubmed

Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.

MKRN4P MKRN1

1.87e-05462211597136
Pubmed

Mouse mutants from chemically mutagenized embryonic stem cells.

FBN2 MEI1

1.87e-05462210700192
Pubmed

Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.

MCM6 CDT1

1.87e-05462218606811
Pubmed

DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.

DNAH5 DNAH9

1.87e-05462218950741
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

KMT2C KMT2D PHF19 ZCCHC8 EXOSC3 CDT1 DNMT1

2.01e-0546962727634302
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

TRAF6 RNF2 MYCBP2 HERC1

2.58e-059562429643511
Pubmed

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.

DNAH5 DNAH9

3.12e-05562226909801
Pubmed

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

KMT2C KMT2D

3.12e-05562231127101
Pubmed

ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.

DNAH5 DNAH9

3.12e-05562223849778
Pubmed

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

KMT2C KMT2D

3.12e-05562232601106
Pubmed

The establishment of rotational polarity in the airway and ependymal cilia: analysis with a novel cilium motility mutant mouse.

DNAH5 DNAH9

3.12e-05562223525783
Pubmed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

KMT2C KMT2D

3.12e-05562226744420
Pubmed

Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal.

TRAF6 SIK1

4.67e-05662224061540
Pubmed

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

DNAH5 DNAH9

4.67e-05662233347437
Pubmed

Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.

C3 ST8SIA1

4.67e-05662227644882
Pubmed

Proliferating cell nuclear antigen interacts with the CRL4 ubiquitin ligase subunit CDT2 in DNA synthesis-induced degradation of CDT1.

CDT1 DNMT1

4.67e-05662230301766
Pubmed

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.

MKRN4P MKRN1

4.67e-05662219536131
Pubmed

Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing re-replication.

MCM6 CDT1

4.67e-05662218184650
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C KMT2D

4.67e-05662217021013
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

NLRP11 KMT2D NSD1 HERC1 DNAH5

6.25e-0523462536243803
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2C KMT2D

6.53e-05762230604749
Pubmed

SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.

RAPSN UTRN

6.53e-05762219509342
Pubmed

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.

KMT2C KMT2D

6.53e-05762236598580
Pubmed

Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos.

MKRN3 DNMT1

6.53e-05762225300248
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH5 DNAH9

6.53e-05762231178125
Pubmed

Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice.

RAPSN UTRN

6.53e-05762211802174
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C KMT2D

6.53e-05762219556342
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KMT2C RNF2 DNMT1

6.78e-054462324183668
Pubmed

Functional proteomics mapping of a human signaling pathway.

KMT2D FBN2 MYCBP2 ZCCHC8 HERC1 UTRN SOX13

8.65e-0559162715231748
Pubmed

Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.

RNF2 CDT1

8.69e-05862218650381
Pubmed

Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.

KMT2C KMT2D

8.69e-05862221447625
Pubmed

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.

KMT2C KMT2D

8.69e-05862230335158
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2C KMT2D

8.69e-05862223130995
Pubmed

Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation.

RAPSN UTRN

8.69e-05862215371519
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2C KMT2D

8.69e-05862222266653
Pubmed

Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice.

RAPSN UTRN

8.69e-05862212832540
Pubmed

RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.

RNF2 DNMT1

8.69e-05862222269950
Pubmed

Fcγ receptor-mediated inflammation inhibits axon regeneration.

C3 ST8SIA1

1.12e-04962224523933
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2C KMT2D

1.12e-04962222665483
Pubmed

Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.

DNAH5 DNAH9

1.12e-04962227353389
Pubmed

DNMT1 interacts with the developmental transcriptional repressor HESX1.

RNF2 DNMT1

1.39e-041062217931718
Pubmed

Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.

C3 ADCY7

1.39e-041062211884542
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KMT2C KMT2D ABR GAREM2 MYCBP2 NISCH NSD1 HERC1 ADCY7

1.43e-04110562935748872
Pubmed

New nomenclature for chromatin-modifying enzymes.

KMT2C KMT2D NSD1

1.47e-045762318022353
Pubmed

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

MKRN3 TRAF6 RAPSN RNF2

1.49e-0414962419549727
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYCBP2 ZCCHC8 POLDIP3 NSD1 MCM6 UTRN DNMT1

1.60e-0465362722586326
Pubmed

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.

KMT2C KMT2D

1.70e-041162237012455
Pubmed

Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.

RAPSN UTRN

1.70e-041162211312300
Pubmed

Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor.

RAPSN UTRN

1.70e-041162212403715
Pubmed

Human transcription factor protein interaction networks.

MED24 NOL4 KMT2C KMT2D FBN2 RNF2 POLDIP3 HERC1 PHF10 SOX13

2.04e-041429621035140242
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2C KMT2D

2.04e-041262227563068
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

MED24 KMT2D RNF2

2.18e-046562322496869
Pubmed

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.

DNAH5 DNAH9

2.41e-041362235942101
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2C KMT2D

2.41e-041362221502505
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C KMT2D

2.41e-041362217761849
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C KMT2D

2.81e-041462212482968
GeneFamilyPHD finger proteins

KMT2C KMT2D PHF19 NSD1 PHF10

3.19e-069046588
GeneFamilyRing finger proteins

MKRN3 MKRN4P TRAF6 RAPSN RNF2 MKRN1

6.59e-0527546658
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2D NSD1

8.73e-0534463487
GeneFamilyDyneins, axonemal

DNAH5 DNAH9

8.41e-0417462536
CoexpressionGSE19401_UNSTIM_VS_RETINOIC_ACID_AND_PAM2CSK4_STIM_FOLLICULAR_DC_DN

CTSF CAMKK2 ABR NISCH RENBP UTRN

7.67e-06199626M7659
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B C3 DNAH5 PKHD1L1 DNAH9 SPINK5

1.52e-0717362666f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B C3 DNAH5 PKHD1L1 DNAH9 SPINK5

1.52e-07173626649b08a409095592cccf31883be69c754411280d
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C MYCBP2 NISCH NSD1 RET HERC1

3.08e-071956263e519cffa6144a62b06124642a14c9ff39b76554
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B DNAH5 PKHD1L1 DNAH9 SPINK5

3.84e-0616962512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM6 RENBP CDT1 ARHGAP11A DNMT1

4.67e-06176625270d7908dbd84028958d257f94941dc685e20255
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 FBN2 DNAH5 PKHD1L1 DNAH9

5.80e-061846252cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 FBN2 DNAH5 PKHD1L1 DNAH9

5.80e-06184625ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 FBN2 DNAH5 PKHD1L1 DNAH9

5.80e-061846252b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

PDE4D COL27A1 C3 DNAH5 SPINK5

6.44e-06188625ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 RAPSN PHF19 MCM6 RET

6.44e-0618862561ae7405ab56570409bf35382dc0a038e4137c15
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NOL4 ASIC2 SIK1 RET VWDE

7.50e-06194625d024cd75a97f048257e49cee9190fb2e79202ee2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

7.50e-061946254c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C MYCBP2 NISCH RET HERC1

7.69e-061956257796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell(4)_B_cells-(4)_B_Hypermutation|(4)_B_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.28e-061986258be724a49b4c911d68c3e82fb75e96722d0eaa03
ToppCellnormal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_DZ|B_lymphocytes / Location, Cell class and cell subclass

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.28e-0619862541e4bc7964a4895dd05bc62f0ef632ce9c89e34f
ToppCellcycling_basal_cell|World / shred by cell class for turbinate

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.28e-06198625e86c1224f5b0890a50a25257628e90c790aae7cd
ToppCellNS-critical-d_16-33-Lymphoid-NKT-proliferating|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.49e-0619962531b144bb209c629e12156f4d9c9cec79baffffb9
ToppCellsevere-Lymphocytic-Prol._cells|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.49e-06199625b24315952b6ac6c8d2d3a7bd949a5b5392624d4e
ToppCellControl-Control-Lymphocyte-T/NK-T/NK_proliferative|Control / Disease, condition lineage and cell class

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-062006256cf63dd57f6bc0c42e7182322dd24ff9afbe9186
ToppCellcontrol-T/NK_proliferative|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-062006251da366e35a05f73253629663eeea1fed4ebd7b52
ToppCellSevere-Developping_Plasmablast|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-062006256d0cd00e52568d23597cc2a4059bd967d7d2dab5
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-0620062504bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-062006257e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-06200625f6b5320cdfe640a71e6e2df26f30d42e64b1c921
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-062006255b014c658eecc5e73679e5feb7a2aaa3d297001d
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-062006259775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCellmild-T/NK_proliferative|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF19 MCM6 CDT1 ARHGAP11A DNMT1

8.70e-0620062563cc57b9331459efbb73051d174d198a3568b938
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ASIC2 PHF10 SOX13 FBN3

4.00e-051376248e2fa2ef8becace96a68bb85c002329110902fbb
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

NOL4 FBN2 ASIC2 DNAH9

5.41e-051486240dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRAF6 MCM6 CDT1 ST8SIA1

5.85e-0515162475c068b3e3aae5f9ba64d5fa5d1e2105a60e4293
ToppCellInt-URO-Lymphocyte-T_NK-CD8_Naive|Int-URO / Disease, Lineage and Cell Type

CTSF PTPRK MCM6 CDT1

6.00e-0515262452d6f9cf1f4637c922f582705d625b4cbe3dc0c2
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RSPH14 DNAH5 DNAH9 SPINK5

8.05e-05164624e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANO9 GAREM2 C3 PKHD1L1

8.64e-051676247abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAPSN PHF19 MCM6 MEI1

8.64e-0516762453e32d6687a07f486141df9f4ab998af4c03a507
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANO9 GAREM2 C3 PKHD1L1

8.64e-05167624d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

RAPSN PPP2R3B MCM6 CDT1

9.68e-051726246fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCellASK454-Epithelial-Transformed_epithelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CPNE2 RNF2 PKHD1L1 SPINK5

9.68e-051726243986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCelldroplet-Fat-Gat-18m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 RSPH14 DNAH5 DNAH9

9.90e-05173624f3f67531f72d6d52e19c7f1f2db1ab4026fb70da
ToppCelldroplet-Fat-Gat-18m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 RSPH14 DNAH5 DNAH9

9.90e-05173624a40a52d8041d45dc3bef74fe55945ae07aa018d6
ToppCelldroplet-Fat-Gat-18m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 RSPH14 DNAH5 DNAH9

9.90e-05173624f0b4dd1cf41d6ee6abb0e1968b8b39f4fabebcb5
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPNE2 COL27A1 ST8SIA1 ZNF606

1.03e-041756241b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTPRK ZNF606 ARHGAP11A SOX13

1.03e-0417562487e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B COL27A1 SIK1 VWDE

1.08e-041776241dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B COL27A1 SIK1 VWDE

1.08e-04177624426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCellfacs-Limb_Muscle-Muscle_Diaphragm-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM6 CDT1 ARHGAP11A DNMT1

1.10e-041786245ac5257d88fa0dc67714881d6f005f6cea925710
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MKRN3 RAPSN RET VWDE

1.10e-0417862413dfd28a80889c2dacdc65b94a41bb9762dc409d
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MKRN3 RAPSN RET VWDE

1.10e-04178624a9ba4089413b1c55d667ce836b6972ca572ee2b8
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B RAPSN RET SOX13

1.10e-04178624408e41c853f608965cef9111fb87fdc311cdc7a8
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5|Striatum / BrainAtlas - Mouse McCarroll V32

VAX1 PHF19 CDT1 ARHGAP11A

1.23e-04183624f20b0d71f857ac35868fd80531050ad8b6091716
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPH14 C3 DNAH5 DNAH9

1.25e-04184624264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 NSD1 SIK1 UTRN

1.25e-041846241154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPH14 C3 DNAH5 DNAH9

1.25e-04184624d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPH14 C3 DNAH5 DNAH9

1.25e-0418462422010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PHF19 CDT1 MEI1 DNMT1

1.25e-041846248260e688ec42a1374727bc85dceb7edd19a8b662
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MKRN3 ZNF12 RENBP PKHD1L1

1.28e-04185624bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMKK2 MYCBP2 NSD1 SIK1

1.28e-041856247adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PHF19 MCM6 CDT1 ARHGAP11A

1.28e-041856249d424a8608b339dd6129c58d87626678d4ec4af7
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PHF19 MCM6 CDT1 ARHGAP11A

1.28e-04185624a3cd0511fa7cf317c3fcb7082fa785bbf51c5cef
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PDE4D PTPRK DNAH5 FBN3

1.31e-041866242ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 C3 VEGFD PKHD1L1

1.34e-041876244e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 C3 VEGFD PKHD1L1

1.34e-04187624d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 C3 VEGFD PKHD1L1

1.34e-04187624827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

PDE4D PTPRK DNAH5 SPINK5

1.34e-041876248407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAMKK2 PDE4D PTPRK ASIC2

1.39e-04189624a75226616340045b581d08429d2e123e041dee55
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAMKK2 PDE4D PTPRK ASIC2

1.42e-04190624d594da827e3c16644952b9589cc12b947ce36279
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CAMKK2 ST8SIA1 RET PKHD1L1

1.42e-041906249ce301841ce9486701fa28eb2a9929e35d476878
ToppCell(02)_Cycling_Basal_(regeneration)|World / shred by cell type and Timepoint

MCM6 CDT1 ARHGAP11A DNMT1

1.42e-0419062453f017a11ca5ebe9025558e12cedc409cab2e5aa
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAMKK2 PDE4D PTPRK ASIC2

1.42e-0419062449e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

PHF19 MCM6 CDT1 ARHGAP11A

1.45e-04191624210a0f1a71df2508cbfc73d6868a2122338b9a1c
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MKRN3 PTPRK MCM6 VEGFD

1.45e-04191624c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCelldroplet-Marrow-BM-1m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM6 CDT1 PKHD1L1 PHF10

1.45e-04191624d78d4fbb0b8317dbf14e32182466a432abef3e93
ToppCellcontrol-T/NK_proliferative|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF19 MCM6 CDT1 ARHGAP11A

1.51e-04193624ecb4018a47d9a82bb999e0bc8b3dceabd97d1f0d
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 CDT1 ARHGAP11A PKHD1L1

1.51e-041936240373984547cefc0cbd77f8e795d508f6fcebc6c8
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PHF19 CDT1 ARHGAP11A DNMT1

1.51e-04193624b835d28de9daeec5213172c96f62b332cda53bb5
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 MCM6 CDT1 ARHGAP11A

1.54e-04194624f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell(1)_T_cells_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PHF19 MCM6 CDT1 ARHGAP11A

1.54e-041946248f313071933451780309d2174ed27d8cdc734343
ToppCellControl-Lymphoid_T/NK-T/NK_proliferative|Control / Disease group, lineage and cell class

PHF19 MCM6 CDT1 ARHGAP11A

1.54e-041946249bbb124001fba7450f4639f47f9b720a483e7242
ToppCellControl-Lymphocyte-T_NK-T_NK_proliferative|Control / Disease, Lineage and Cell Type

PHF19 MCM6 CDT1 DNMT1

1.54e-04194624844731b7943d1cfca819b7b89e4e62067bfa0230
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PHF19 MCM6 CDT1 ARHGAP11A

1.54e-04194624a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 MCM6 CDT1 ARHGAP11A

1.54e-0419462417744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ASIC2 SIK1 RET ZNF606

1.54e-04194624ea5b7727ffef6cb454c501979a51bc1d4108d0e4
ToppCell(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

PHF19 MCM6 CDT1 ARHGAP11A

1.54e-041946244d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CDT1 UTRN PHF10 DNMT1

1.54e-04194624dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PHF19 MCM6 CDT1 ARHGAP11A

1.54e-04194624e14f66f7584909621b776292fbd52808273fd2ee
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

PDE4D PTPRK DNAH5 DNAH9

1.57e-04195624fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE4D MYCBP2 HERC1 UTRN

1.57e-041956244b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PHF19 CDT1 ARHGAP11A DNMT1

1.57e-0419562467670d16ddd5d5ab7bc2254df329f5a7b2581556
ToppCelltumor_Lung-B_lymphocytes-GC_B_cells_in_the_DZ|B_lymphocytes / Location, Cell class and cell subclass

PHF19 CDT1 ARHGAP11A DNMT1

1.57e-04195624339e81a3a5b1f71c0d15ef1ef0f6999378704923
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PHF19 CDT1 ARHGAP11A DNMT1

1.57e-0419562423dc2f8a3a038195a31feee7e3a51094a7a7c23e
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

PDE4D PTPRK DNAH5 DNAH9

1.57e-04195624eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-041966246d80e23f6a1725a3f5ea7263233c55c2ea56f977
ToppCellBAL-Control-Myeloid-Myeloid|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-04196624bf1d3fae8c01bb3d17c2dafad92b94937c663acd
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-041966249d4f0a95e49bda25864cbe27e4e86096cba5609f
ToppCellcycling_basal_cell|World / shred by cell class for nasal brushing

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-04196624aa7bac70a2fe4a3cb28d89fa1a87c68c2ead1349
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

PDE4D PTPRK DNAH5 DNAH9

1.60e-04196624af4cdc61830685a888a1209826c23bcf54a43084
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-041966243dd7ed1dfac8d90c8a44f0ae00128bb46d9ef496
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-041966244f649e3bfd21f21682678828673843a7d51c4ff2
ToppCellBAL-Control-Myeloid-Myeloid|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-04196624799c290fb3dfacb666dd0dc3c43ec8a86b697ec7
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

PDE4D PTPRK DNAH5 DNAH9

1.60e-041966246d02d494196e3f857d53eea46d9419690d43beca
ToppCellBAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 MCM6 CDT1 ARHGAP11A

1.60e-041966240c003a767c3b58605099dab64b9df0d8e5d8bc4b
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

4.34e-062622DOID:0080598 (implicated_via_orthology)
Diseaseconnective tissue disease (implicated_via_orthology)

FBN2 FBN3

1.30e-053622DOID:65 (implicated_via_orthology)
DiseaseProstatic Neoplasms

KMT2C KMT2D CAMKK2 PDE4D ABR PTPRK DNMT1 SPINK5

4.32e-05616628C0033578
DiseaseMalignant neoplasm of prostate

KMT2C KMT2D CAMKK2 PDE4D ABR PTPRK DNMT1 SPINK5

4.32e-05616628C0376358
Diseaselaryngeal carcinoma (is_marker_for)

KMT2C TRAF6

6.48e-056622DOID:2600 (is_marker_for)
Diseaseparathyroid hormone measurement

RSPH14 PDE4D ASIC2

2.14e-0455623EFO_0004752
DiseaseHirschsprung's disease (implicated_via_orthology)

MED24 RET

2.83e-0412622DOID:10487 (implicated_via_orthology)
DiseaseSitus ambiguus

DNAH5 DNAH9

4.48e-0415622C0266642
DiseaseIGF-1 measurement

MED24 ZNF12 PDE4D RAPSN GAREM2 DNMT1

5.57e-04488626EFO_0004627
DiseaseAsthma

PDE4D DNAH5 DNMT1

6.47e-0480623C0004096
Diseaseotitis media (implicated_via_orthology)

NISCH DNAH5

9.77e-0422622DOID:10754 (implicated_via_orthology)
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

KMT2D RET

1.07e-0323622C1708353
Diseaseresponse to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema

PDE4D VWDE

1.37e-0326622EFO_0005325, EFO_0005532, EFO_0010735
DiseaseSezary Syndrome

KMT2C KMT2D

1.47e-0327622C0036920
Diseaselysophosphatidylcholine 20:4 measurement

RAPSN MYCBP2

2.07e-0332622EFO_0010363

Protein segments in the cluster

PeptideGeneStartEntry
ALSDPAAKENCMMHL

ABR

746

Q12979
SLCDGDMEKPIQVMC

CPNE2

216

Q96FN4
CQERRCPNMAMKEAD

DNMT1

686

P26358
CCTIMSPGEMEKHLL

CDT1

486

Q9H211
RKCCEDGMRENPMRF

C3

691

P01024
PTHARNCVKMGLDMC

ADCY7

341

P51828
KLEECHASGCMMDLF

ANO9

461

A1A5B4
MKNCMDVDECARDPL

FBN3

1066

Q75N90
IVENCNCRMVHMPGD

ASIC2

316

Q16515
CDMCGLQVLHPMDAA

MKRN4P

271

Q13434
EMCPSSFCKQHREGM

NSD1

2176

Q96L73
TMDDMGLVAKACGCP

PPP2R3B

161

Q9Y5P8
MECCEESMKIALQHG

RAPSN

226

Q13702
FHVPRCLAMCEEMLG

RENBP

391

P51606
MARMHCCDEVQPKHV

MCM6

631

Q14566
PELQKDMLHCNMCKR

KMT2C

476

Q8NEZ4
HPNCMLVNIGLEECM

NLRP11

886

P59045
PDGKMHGNTCSMCEA

SPINK5

461

Q9NQ38
CLKECPCMKGGTDMQ

FAM184B

376

Q9ULE4
GVEMDTPQLDKCMSC

HERC1

1181

Q15751
LMQLSMDCPCDLADG

RCE1

131

Q9Y256
DHFLCEMPALIGMAC

OR2W6P

181

Q8NHA6
ERGMEISPMCDKHNA

PDE4D

651

Q08499
DECHKELCNMPSMRG

MEI1

136

Q5TIA1
CIICGQPHHEEEMMF

PHF10

436

Q8WUB8
CDKMDKACMGGLPSN

CTSF

326

Q9UBX1
PARVCRDLMDCEQKM

COL27A1

1686

Q8IZC6
GQCPFMDERIMCLHS

CAMKK2

386

Q96RR4
ITHPCMESAEGKRMQ

DNAH9

631

Q9NYC9
GLHDCESRGMMCKNL

FBN2

2301

P35556
NKDMEPEMVCIDSCG

EXOSC3

171

Q9NQT5
HSELMCPICLDMLKN

RNF2

46

Q99496
CIHTLMRAMTDCGKP

DNAH5

2271

Q8TE73
NRCLDGQPMKCNLHM

POLDIP3

336

Q9BY77
HDKNRFMDMLPPDRC

PTPRK

1201

Q15262
CDMCGLQVLHPMDAA

MKRN1

236

Q9UHC7
GKMPCLICMNHRTNE

GAREM2

211

Q75VX8
MHKDLVNVPLCVDMC

UTRN

2921

P46939
ENMMEGNLPKCAAHS

ARHGAP11A

741

Q6P4F7
MDMFCDRLSCHGKAE

MED24

101

O75448
SHICFGMKSPEEMRQ

POLR3A

16

O14802
LLQGDCEMEDLMPCS

SIK1B

761

A0A0B4J2F2
LLQGDCEMEDLMPCS

SIK1

761

P57059
QMEDCCDPAHLFAMT

ST8SIA1

81

Q92185
KQMPMCDNHDDGETA

MYCBP2

4256

O75592
MSCSECQKRMHLNPD

NOL4

156

O94818
RPAEMPTKCVEMNHC

VWDE

71

Q8N2E2
CVHPLEEAMLSCDMD

SOX13

396

Q9UN79
NCGSEEHQMKDCPMP

ZCCHC8

231

Q6NZY4
PNAHSCEMCILVMKD

ZNF549

101

Q6P9A3
CDMCGLQTLHPMDAA

MKRN3

266

Q13064
CRMLSDLCQGSMHSP

NPVF

141

Q9HCQ7
ALMALCDLMHDPECI

RSPH14

46

Q9UHP6
MVKCPNEGCLHKMEL

TRAF6

131

Q9Y4K3
DLRSCFAPQHMAMLC

NISCH

806

Q9Y2I1
HEACTQCLNEPMMFG

PHF19

221

Q5T6S3
LKLDHPNGDMGSMVC

PKHD1L1

211

Q86WI1
TGHRMERPDNCSEEM

RET

966

P07949
TSHMEMKPYECSECG

ZNF12

261

P17014
ALCGPHMMFDEDRCE

VEGFD

256

O43915
MRMHTGEKPFKCDEC

ZNF606

531

Q8WXB4
MFGKPDKMDVRCHSD

VAX1

1

Q5SQQ9
MLCPMHKIKGPCEQE

KMT2D

5131

O14686