Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-affinity D-glucose:sodium symporter activity	SLC5A9 SLC5A4	1.22e-04	3	128	2	GO:0005362
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	TESK2 DYRK1B DYRK3 AURKB	2.32e-04	47	128	4	GO:0004712
GeneOntologyMolecularFunction	aliphatic amine oxidase activity	AOC2 AOC3	2.43e-04	4	128	2	GO:0052595
GeneOntologyMolecularFunction	cytoskeletal anchor activity	MAP1A OBSL1 MARK4	4.72e-04	24	128	3	GO:0008093
GeneOntologyMolecularFunction	protein serine kinase activity	MAP3K14 SNRK TESK2 MARK4 DYRK1B ALPK2 PKN3 DYRK3 AURKB	5.61e-04	363	128	9	GO:0106310
Domain	-	AOC2 AOC3	1.37e-04	3	127	2	2.70.98.20
Domain	Cu_amine_oxidase_N3	AOC2 AOC3	1.37e-04	3	127	2	IPR015802
Domain	Cu_amine_oxidase_N2	AOC2 AOC3	1.37e-04	3	127	2	IPR015800
Domain	COPPER_AMINE_OXID_1	AOC2 AOC3	1.37e-04	3	127	2	PS01164
Domain	COPPER_AMINE_OXID_2	AOC2 AOC3	1.37e-04	3	127	2	PS01165
Domain	Cu_amine_oxidN2	AOC2 AOC3	1.37e-04	3	127	2	PF02727
Domain	Cu_amine_oxidN3	AOC2 AOC3	1.37e-04	3	127	2	PF02728
Domain	Cu_amine_oxidase_N-reg	AOC2 AOC3	1.37e-04	3	127	2	IPR016182
Domain	Cu_amine_oxid	AOC2 AOC3	1.37e-04	3	127	2	PF01179
Domain	Cu_amine_oxidase_C	AOC2 AOC3	1.37e-04	3	127	2	IPR015798
Domain	Terpenoid_cyclase/PrenylTrfase	ASIC3 C4A C4B	2.33e-04	18	127	3	IPR008930
Domain	Cu_amine_oxidase	AOC2 AOC3	2.73e-04	4	127	2	IPR000269
Domain	NUT	NUTM2A NUTM2B	4.53e-04	5	127	2	IPR024310
Domain	NUT_N	NUTM2A NUTM2B	4.53e-04	5	127	2	IPR024309
Domain	Anaphylatoxin_comp_syst	C4A C4B	4.53e-04	5	127	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	4.53e-04	5	127	2	IPR001840
Domain	NUT	NUTM2A NUTM2B	4.53e-04	5	127	2	PF12881
Domain	ANATO	C4A C4B	9.42e-04	7	127	2	SM00104
Domain	Hr1	RTKN PKN3	9.42e-04	7	127	2	SM00742
Domain	ANAPHYLATOXIN_2	C4A C4B	9.42e-04	7	127	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	9.42e-04	7	127	2	PS01177
Domain	ANATO	C4A C4B	9.42e-04	7	127	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	9.42e-04	7	127	2	IPR000020
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.25e-03	8	127	2	IPR019565
Domain	HR1	RTKN PKN3	1.25e-03	8	127	2	PF02185
Domain	Thiol-ester_cl	C4A C4B	1.25e-03	8	127	2	PF10569
Domain	Na/solute_symporter_CS	SLC5A9 SLC5A4	1.25e-03	8	127	2	IPR018212
Domain	MacrogloblnA2_CS	C4A C4B	1.25e-03	8	127	2	IPR019742
Domain	A2M	C4A C4B	1.99e-03	10	127	2	PF00207
Domain	A2M_N_2	C4A C4B	1.99e-03	10	127	2	IPR011625
Domain	A2M_comp	C4A C4B	1.99e-03	10	127	2	IPR011626
Domain	A2M_recep	C4A C4B	1.99e-03	10	127	2	PF07677
Domain	A2M_comp	C4A C4B	1.99e-03	10	127	2	PF07678
Domain	A2M_N	C4A C4B	1.99e-03	10	127	2	PF01835
Domain	A2M_N	C4A C4B	1.99e-03	10	127	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.99e-03	10	127	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.99e-03	10	127	2	PS00477
Domain	A2M_N_2	C4A C4B	1.99e-03	10	127	2	PF07703
Domain	Macroglobln_a2	C4A C4B	1.99e-03	10	127	2	IPR001599
Domain	BAH	TNRC18 BAHCC1	2.42e-03	11	127	2	PS51038
Domain	BAH_dom	TNRC18 BAHCC1	2.42e-03	11	127	2	IPR001025
Domain	BAH	TNRC18 BAHCC1	2.42e-03	11	127	2	SM00439
Domain	NA_SOLUT_SYMP_1	SLC5A9 SLC5A4	2.42e-03	11	127	2	PS00456
Domain	BAH	TNRC18 BAHCC1	2.42e-03	11	127	2	PF01426
Domain	SSF	SLC5A9 SLC5A4	2.90e-03	12	127	2	PF00474
Domain	NA_SOLUT_SYMP_2	SLC5A9 SLC5A4	2.90e-03	12	127	2	PS00457
Domain	Na/solute_symporter	SLC5A9 SLC5A4	2.90e-03	12	127	2	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A9 SLC5A4	2.90e-03	12	127	2	PS50283
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ARHGAP23 RTKN ARHGEF17 STX5 ARHGAP31 PKN3 ARAP1	2.92e-05	142	88	7	MM15576
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ARHGAP23 RTKN ARHGEF17 STX5 ARHGAP31 PKN3 ARAP1	3.97e-05	149	88	7	M41805
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOC2A CTC1 AOC2 C15orf39 AMBRA1 TBC1D25 SFI1 NCLN WASHC2A STK11IP RYR1 PHC2 LIME1 NCOR1 TNRC18 MGAT1 KANSL1 ADAMTS7 ZNF592 IL17RE KLHL21 CASKIN1 SBF2 MARK4 KBTBD11 BCAM MAPKBP1 METTL27 PKN3 ARAP1 MVB12B BAHCC1	1.28e-19	1105	131	32	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUT4 MAP1A ARHGAP23 RANBP9 OBSL1 KIAA1549 AMBRA1 PDCD2L ZNF318 ACTL7A PJA2 ZNF592 ZC3H4 KLHL21 MARK4 WDR62 SEZ6L AURKB BAHCC1	4.24e-08	1116	131	19	31753913
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA1549 AMBRA1 SNRK SFI1 RRBP1 ZNF592 ARHGAP31 ZC3H4 KLHL21 PPM1F CASKIN1 KBTBD11 ARAP1	1.14e-07	529	131	13	14621295
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PDE3B HIVEP1 KIF26B MAP3K14 RALGAPB CAMSAP3 RTKN ARHGEF17 AKT1S1 PJA2 STX5 TESK2 MARK4 DYRK1B MTCL1 WDR62	1.69e-07	861	131	16	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPB OBSL1 GPATCH8 ARHGEF17 WASHC2A PJA2 KANSL1 MARK4 MTCL1 MAPKBP1 SEZ6L	4.45e-07	407	131	11	12693553
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	OBSL1 AMBRA1 PDCD2L NCLN STK11IP PJA2 MOGS PPM1F DYRK1B CAPRIN1 PKN3 WDR62 AURKB	5.34e-07	606	131	13	36538041
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PDE3B ARHGAP23 RALGAPB CAMSAP3 OBSL1 C15orf39 AMBRA1 RRBP1 NCLN MOGS ZC3H4 C4A C4B	1.17e-06	650	131	13	38777146
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	HIVEP1 RALGAPB CAMSAP3 ZNF318 GPATCH8 RRBP1 AKT1S1 PHC2 NCOR1 KANSL1 ZNF592 ZC3H4 WDR62	7.76e-06	774	131	13	15302935
Pubmed	The DNA sequence and biology of human chromosome 19.	NCLN ZNRF4 RYR1 DYRK1B GRIN3B ONECUT3 MADCAM1 WDR62	1.30e-05	284	131	8	15057824
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.41e-05	2	131	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.41e-05	2	131	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.41e-05	2	131	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.41e-05	2	131	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.41e-05	2	131	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.41e-05	2	131	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.41e-05	2	131	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.41e-05	2	131	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.41e-05	2	131	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.41e-05	2	131	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.41e-05	2	131	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.41e-05	2	131	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.41e-05	2	131	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.41e-05	2	131	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.41e-05	2	131	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.41e-05	2	131	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.41e-05	2	131	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.41e-05	2	131	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.41e-05	2	131	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.41e-05	2	131	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.41e-05	2	131	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.41e-05	2	131	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.41e-05	2	131	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.41e-05	2	131	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.41e-05	2	131	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.41e-05	2	131	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.41e-05	2	131	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.41e-05	2	131	2	1699796
Pubmed	Identification of a region within the placental alkaline phosphatase mRNA that mediates p180-dependent targeting to the endoplasmic reticulum.	RRBP1 ALPP	1.41e-05	2	131	2	24019514
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.41e-05	2	131	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.41e-05	2	131	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.41e-05	2	131	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.41e-05	2	131	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.41e-05	2	131	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.41e-05	2	131	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.41e-05	2	131	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.41e-05	2	131	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.41e-05	2	131	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.41e-05	2	131	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.41e-05	2	131	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.41e-05	2	131	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.41e-05	2	131	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.41e-05	2	131	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.41e-05	2	131	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.41e-05	2	131	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.41e-05	2	131	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.41e-05	2	131	2	34358307
Pubmed	The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase.	AOC2 AOC3	1.41e-05	2	131	2	19588076
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.41e-05	2	131	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.41e-05	2	131	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.41e-05	2	131	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.41e-05	2	131	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.41e-05	2	131	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.41e-05	2	131	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.41e-05	2	131	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.41e-05	2	131	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.41e-05	2	131	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.41e-05	2	131	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.41e-05	2	131	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.41e-05	2	131	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.41e-05	2	131	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.41e-05	2	131	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	1.41e-05	2	131	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	1.41e-05	2	131	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	1.41e-05	2	131	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	1.41e-05	2	131	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.41e-05	2	131	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	1.41e-05	2	131	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.41e-05	2	131	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	1.41e-05	2	131	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.41e-05	2	131	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	1.41e-05	2	131	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.41e-05	2	131	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	1.41e-05	2	131	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	1.41e-05	2	131	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	1.41e-05	2	131	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.41e-05	2	131	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.41e-05	2	131	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.41e-05	2	131	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	1.41e-05	2	131	2	3944109
Pubmed	Anatomical distribution of primary amine oxidase activity in four adipose depots and plasma of severely obese women with or without a dysmetabolic profile.	AOC2 AOC3	1.41e-05	2	131	2	27766585
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.41e-05	2	131	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.41e-05	2	131	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.41e-05	2	131	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.41e-05	2	131	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	1.41e-05	2	131	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	1.41e-05	2	131	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.41e-05	2	131	2	28873507
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	1.41e-05	2	131	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	1.41e-05	2	131	2	2900855
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.41e-05	2	131	2	276882
Interaction	TOP3B interactions	DOC2A CNOT11 CTC1 AOC2 C15orf39 AMBRA1 TBC1D25 SFI1 NCLN WASHC2A STK11IP RYR1 PHC2 LIME1 NCOR1 TNRC18 MGAT1 KANSL1 MOGS ADAMTS7 ZNF592 IL17RE KLHL21 CASKIN1 SBF2 MARK4 KBTBD11 BCAM MAPKBP1 METTL27 CAPRIN1 PKN3 ARAP1 MVB12B BAHCC1	2.70e-12	1470	126	35	int:TOP3B
Interaction	RCOR1 interactions	EPS15 HIVEP1 TLX3 CAMSAP3 RANBP9 C15orf39 ZNF318 NCOR1 ZNF592 VARS1 PKN3 WDR62 AURKB	1.35e-05	494	126	13	int:RCOR1
Cytoband	19p13.3	PLK5 NCLN ZNRF4 GRIN3B ONECUT3 MADCAM1	6.48e-05	237	131	6	19p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	PDCD2L HIF3A KIRREL2 AKT1S1 RYR1 ZC3H4 MARK4 DYRK1B BCAM KIR2DL4 SLC27A5 WDR62	1.66e-04	1192	131	12	chr19q13
Cytoband	11q12.3	STX5 LRRN4CL ZBTB3	1.78e-04	38	131	3	11q12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr10q23	NUTM2A PDLIM1 FGFBP3 MARCHF5 STAMBPL1	2.53e-04	195	131	5	chr10q23
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	ABI3 AOC2 MAP3K14 GPATCH8 DHX8 KANSL1 AOC3	4.39e-04	473	131	7	chr17q21
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	INHA OBSL1 STK11IP IHH	5.29e-04	129	131	4	chr2q35
Cytoband	17q21	AOC2 MAP3K14 AOC3	7.96e-04	63	131	3	17q21
Cytoband	17q21.31	GPATCH8 DHX8 KANSL1	1.71e-03	82	131	3	17q21.31
Cytoband	1p32	EPS15 TESK2	2.71e-03	27	131	2	1p32
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP23 RTKN SBF2 FGD1 ARAP1 PSD4	5.07e-04	206	88	6	682
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B BCAM	7.68e-04	37	88	3	454
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	8.25e-04	9	88	2	1234
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CAMSAP3 SFI1 RYR1 NCOR1 AURKB	1.91e-03	181	88	5	694
Coexpression	GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP	AMBRA1 NLRP1 ZNF318 MGAT1 STX5 MOGS ZC3H4 BCAM	7.47e-06	199	131	8	M7254
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KIAA1549 SOCS7 XYLT1 WDR97 PKHD1 IHH DYRK3	1.29e-06	185	131	7	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP23 ASIC3 PJA2 NKD1 ARHGAP31 IL17RE	6.17e-06	153	131	6	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 C15orf39 VWA7 FGD1 C4A DYRK3	1.05e-05	168	131	6	b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell	CD8+_Memory_T_cell-FLU-3\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	SCFD2 PDLIM1 PPM1F LRP11 MADCAM1 WDR62	1.20e-05	172	131	6	45ac433dbb3796f69e886c04457b2971403050ee
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	KIF26B XYLT1 ARHGAP31 AOC3 CHRD ALPK2	1.46e-05	178	131	6	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABI3 SNRK PPM1F BCAM MADCAM1 AURKB	1.99e-05	188	131	6	5d166d9e71632edd059ff0a9f66f8763f259d40a
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 SNRK PDLIM1 ARHGAP31 BCAM PKN3	2.05e-05	189	131	6	d52fc275976a625b014fa36f62ef07dddf1ffa43
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 SNRK PDLIM1 ARHGAP31 BCAM PKN3	2.05e-05	189	131	6	199cec36fbbc1288771b9edf22143c34ab990af1
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 SNRK PDLIM1 ARHGAP31 BCAM PKN3	2.11e-05	190	131	6	0a211e7dc515926b488f04c6248f6c7e61c2da87
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 SNRK PDLIM1 ARHGAP31 PPM1F BCAM	2.24e-05	192	131	6	24d28e28a5c54ca7770f7e5ad7f4d00039e0aaf9
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TUT4 HIVEP1 HIF3A RRBP1 KANSL1 NKD1	2.24e-05	192	131	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	TUT4 HIVEP1 HIF3A RRBP1 KANSL1 NKD1	2.31e-05	193	131	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma\|TCGA-Adrenal / Sample_Type by Project: Shred V9	MAP1A INSM1 NLRP1 ARHGEF17 MTCL1 SEZ6L	2.38e-05	194	131	6	b6488bc3a8905e926ad298332963e1bbaf010046
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma\|TCGA-Adrenal / Sample_Type by Project: Shred V9	MAP1A INSM1 NLRP1 ARHGEF17 MTCL1 SEZ6L	2.38e-05	194	131	6	1e1f4139ad584f493d75a9b7f1568eca4653c5a2
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 INSM1 ARHGEF17 LRP11 ZFHX2 SEZ6L	2.45e-05	195	131	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABI3 SNRK ARHGAP31 PPM1F BCAM MADCAM1	2.45e-05	195	131	6	f65053811074a7f2ff0368f3a63b88e2a08da1a0
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CAMSAP3 RRBP1 IL17RE PKHD1 MTCL1 BCAM	2.59e-05	197	131	6	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOC2A GPATCH8 KANSL1 PKHD1 BCAM ALPK2	2.74e-05	199	131	6	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABI3 SNRK ARHGAP31 PPM1F BCAM MADCAM1	2.82e-05	200	131	6	ae6cc5462a8a254682793fb8cc348b9721c729bf
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP3K14 KANSL1 CASKIN1 C4A C4B	3.18e-05	123	131	5	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
Drug	Oxamniquine [21738-42-1]; Up 200; 14.4uM; MCF7; HT_HG-U133A	MAP1A ZNF318 SFI1 HIF3A ZNF592 DYRK1B MADCAM1 WDR62 ARAP1	1.86e-06	195	130	9	4124_UP
Drug	phenamil	AOC2 ASIC3 AOC3 PKHD1	1.38e-05	26	130	4	CID000004755
Drug	Ambroxol hydrochloride [23828-92-4]; Down 200; 9.6uM; HL60; HG-U133A	EPS15 PDE3B NCOR1 MGAT1 KLHL21 PPM1F TESK2 ARAP1	1.49e-05	192	130	8	1623_DN
Drug	Antazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	DOC2A PDE3B SFI1 RRBP1 MARK4 WDR62 ARAP1 BAHCC1	1.67e-05	195	130	8	3173_DN
Drug	Palmatine chloride [3486-67-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	DOC2A CTC1 POU3F4 ZNF318 ASIC3 RYR1 PHC2 BAHCC1	1.67e-05	195	130	8	2795_UP
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	MAP1A C15orf39 ZNF318 SFI1 RRBP1 ARHGEF17 PPM1F BAHCC1	1.86e-05	198	130	8	7035_UP
Drug	(-)-Cinchonidine [485-71-2]; Up 200; 13.6uM; HL60; HG-U133A	PDE3B TUT4 RALGAPB AMBRA1 SFI1 KLHL21 MAPKBP1 SLC27A5	1.93e-05	199	130	8	1780_UP
Drug	Monocrotaline [315-22-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A	PRUNE2 AMBRA1 POU3F4 ARHGEF17 RYR1 MARK4 WDR62 ARAP1	1.93e-05	199	130	8	6771_UP
Drug	Xylometazoline hydrochloride [1218-35-5]; Down 200; 14.2uM; MCF7; HT_HG-U133A	PDE3B RRBP1 KLHL21 KBTBD11 FGD1 MAPKBP1 WDR62 DYRK3	1.93e-05	199	130	8	2270_DN
Drug	1,1-dimethylbiguanide hydrochloride; Up 200; 10uM; MCF7; HG-U133A	PRUNE2 AOC2 OBSL1 AMBRA1 SFI1 RRBP1 IHH BAHCC1	1.93e-05	199	130	8	1_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; MCF7; HT_HG-U133A	PDE3B C15orf39 AMBRA1 ZNF318 RRBP1 PPM1F BAHCC1 PSD4	2.00e-05	200	130	8	4841_DN
Drug	DPGBG	AOC2 AOC3	3.24e-05	2	130	2	CID005356884
Drug	monopropionylcadaverine	AOC2 AOC3	3.24e-05	2	130	2	CID000194207
Drug	1-carboxymethylpyridinium	AOC2 AOC3	3.24e-05	2	130	2	CID000080439
Drug	supinidine	AOC2 AOC3	3.24e-05	2	130	2	CID000164663
Drug	diphenylglyoxal bis(guanylhydrazone	AOC2 AOC3	3.24e-05	2	130	2	CID000357080
Drug	AC1Q77R6	AOC2 AOC3	3.24e-05	2	130	2	CID000094259
Drug	p-dimethylaminomethylbenzaldehyde	AOC2 AOC3	3.24e-05	2	130	2	CID000193251
Drug	isoputreanine	AOC2 AOC3	3.24e-05	2	130	2	CID000171763
Drug	N-(3-aminopropyl)pyrrolidin-2-one	AOC2 AOC3	3.24e-05	2	130	2	CID000082111
Drug	Clenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; HL60; HG-U133A	PDE3B RALGAPB ZNF318 RRBP1 MGAT1 STX5 MAPKBP1	8.29e-05	181	130	7	1613_UP
Drug	Sch 34826	MAP3K14 OPRK1 BCAM	9.65e-05	16	130	3	CID000122184
Drug	AC1L1B7L	AOC2 AOC3	9.67e-05	3	130	2	CID000026477
Drug	(+)-Cyanustine	AOC2 AOC3	9.67e-05	3	130	2	CID000028846
Drug	propylglyoxal	AOC2 AOC3	9.67e-05	3	130	2	CID000123249
Drug	3-Hydroxycadaverine	AOC2 AOC3	9.67e-05	3	130	2	CID000435285
Drug	5-fluoropentane-1,4-diamine	AOC2 AOC3	9.67e-05	3	130	2	CID010011890
Drug	NSD-1531	AOC2 AOC3	9.67e-05	3	130	2	CID003014318
Drug	necic acid	AOC2 AOC3	9.67e-05	3	130	2	CID006440847
Drug	AC1L34PU	AOC2 AOC3	9.67e-05	3	130	2	CID000134498
Drug	N-(4-aminobutyl)aziridine	AOC2 AOC3	9.67e-05	3	130	2	CID000152643
Drug	2-aminothiophenol	C4A C4B	9.67e-05	3	130	2	ctd:C005464
Drug	alpha-difluoromethyl putrescine	AOC2 AOC3	9.67e-05	3	130	2	CID000135151
Drug	ketosuccinamate	AOC2 AOC3	9.67e-05	3	130	2	CID000439716
Drug	N-(3-aminopropyl)aziridine	AOC2 AOC3	9.67e-05	3	130	2	CID000014076
Drug	1,2,4-trinitrobenzene	NLRP1 BCAM	9.67e-05	3	130	2	CID000123076
Drug	3-aminopropionamide	AOC2 AOC3	9.67e-05	3	130	2	CID000192802
Drug	pentafluorobenzamide	AOC2 AOC3	9.67e-05	3	130	2	CID000069547
Drug	acisoga	AOC2 AOC3	9.67e-05	3	130	2	CID000129397
Drug	Nazlinine	AOC2 AOC3	9.67e-05	3	130	2	CID000126237
Drug	5-aminopentanal	AOC2 AOC3	9.67e-05	3	130	2	CID000443849
Drug	h202	AOC2 AOC3	9.67e-05	3	130	2	CID000013826
Drug	amicarbalide	AOC2 AOC3	9.67e-05	3	130	2	CID000072074
Drug	C10974	AOC2 AOC3	9.67e-05	3	130	2	CID000443042
Drug	ethylmethylglyoxal bis(guanylhydrazone	AOC2 AOC3	9.67e-05	3	130	2	CID000129202
Drug	radicicol; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	HIVEP1 ZNF318 RRBP1 DNAAF2 ZNF592 MARK4 BAHCC1	1.12e-04	190	130	7	836_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	PDE3B C15orf39 AMBRA1 SFI1 MOGS PPM1F BAHCC1	1.12e-04	190	130	7	5586_DN
Drug	geldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	HIVEP1 C15orf39 ARHGEF17 PPM1F MARK4 MAPKBP1 BAHCC1	1.24e-04	193	130	7	864_DN
Drug	Flucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A	AOC2 SFI1 OPRK1 MARK4 KBTBD11 FGD1 BCAM	1.28e-04	194	130	7	6507_UP
Drug	Lovastatin [75330-75-5]; Down 200; 9.8uM; MCF7; HT_HG-U133A	RALGAPB C15orf39 RRBP1 FGD1 WDR62 DYRK3 PSD4	1.36e-04	196	130	7	4978_DN
Drug	Labetalol hydrochloride [32780-64-6]; Down 200; 11uM; MCF7; HT_HG-U133A	PDE3B RRBP1 SOCS7 KLHL21 MARK4 BCAM DYRK3	1.36e-04	196	130	7	3167_DN
Drug	topiramate; Down 200; 3uM; MCF7; HT_HG-U133A_EA	PDE3B CTC1 ARHGEF17 STX5 BCAM MAPKBP1 DYRK3	1.36e-04	196	130	7	915_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	AMBRA1 SFI1 DHX8 NCOR1 STX5 PPM1F BCAM	1.41e-04	197	130	7	6222_DN
Drug	Myosmine [532-12-7]; Up 200; 27.4uM; MCF7; HT_HG-U133A	ASIC3 ADAMTS7 MARK4 BCAM IHH MADCAM1 MVB12B	1.41e-04	197	130	7	6055_UP
Drug	Finasteride [98319-26-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	RRBP1 FGD1 IHH MAPKBP1 MADCAM1 ARAP1 MVB12B	1.41e-04	197	130	7	4766_UP
Drug	Prilocaine hydrochloride [1786-81-8]; Up 200; 15.6uM; MCF7; HT_HG-U133A	NLRP1 SFI1 MARK4 KBTBD11 ZFHX2 WDR62 DYRK3	1.45e-04	198	130	7	3624_UP
Drug	Flurbiprofen [5104-49-4]; Down 200; 16.4uM; MCF7; HT_HG-U133A	PDE3B TUT4 MAP3K14 ZNF318 SFI1 RRBP1 MARK4	1.45e-04	198	130	7	6472_DN
Drug	Gabazine [105538-73-6]; Down 200; 10.8uM; HL60; HT_HG-U133A	NLRP1 MOGS ZNF592 MARK4 ZBTB3 ARAP1 DYRK3	1.45e-04	198	130	7	1316_DN
Drug	Nialamide [51-12-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	PRUNE2 PDE3B TLX3 CEMP1 ZFHX2 IHH SEZ6L	1.45e-04	198	130	7	4525_UP
Drug	Alverine citrate salt [5560-59-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A	PDE3B ARHGEF17 RYR1 SOCS7 MARK4 BCAM MVB12B	1.45e-04	198	130	7	2273_UP
Drug	Epitiostanol [2363-58-8]; Up 200; 13uM; PC3; HT_HG-U133A	DOC2A CTC1 NLRP1 RRBP1 ARHGEF17 IHH SEZ6L	1.50e-04	199	130	7	4204_UP
Drug	Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; MCF7; HT_HG-U133A	AOC2 OBSL1 SFI1 PPM1F MARK4 ZFHX2 PSD4	1.50e-04	199	130	7	2635_UP
Drug	Leucomisine [17946-87-1]; Up 200; 16.2uM; HL60; HT_HG-U133A	DOC2A CTC1 INSM1 PTGER4 FGD1 MADCAM1 DYRK3	1.50e-04	199	130	7	6125_UP
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	ZNF318 SFI1 PPM1F BCAM ARAP1 MVB12B PSD4	1.50e-04	199	130	7	7439_UP
Drug	Mepenzolate bromide [76-90-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A	PRUNE2 TLX3 POU3F4 PTGER4 IHH SEZ6L MVB12B	1.50e-04	199	130	7	6024_UP
Drug	malonamate	AOC2 AOC3	1.93e-04	4	130	2	CID000075367
Drug	Eovist (TN)	AOC2 AOC3	1.93e-04	4	130	2	CID009961939
Drug	N-acetyl-1,6-diaminohexane	AOC2 AOC3	1.93e-04	4	130	2	CID000162081
Drug	3-aminooxy-2-fluoro-1-propanamine	AOC2 AOC3	1.93e-04	4	130	2	CID000126496
Drug	2-Butene-1,4-diamine	AOC2 AOC3	1.93e-04	4	130	2	CID000148401
Drug	N-methylpyrrolinium	AOC2 AOC3	1.93e-04	4	130	2	CID000440932
Drug	1,4-diamino-2-butyne	AOC2 AOC3	1.93e-04	4	130	2	CID000124159
Drug	2-aminoresorcinol	AOC2 AOC3	1.93e-04	4	130	2	CID000069450
Drug	AC1Q3E6A	AOC2 AOC3	1.93e-04	4	130	2	CID000068318
Drug	spermic acid	AOC2 AOC3	1.93e-04	4	130	2	CID000167029
Drug	lanthionamine	AOC2 AOC3	1.93e-04	4	130	2	CID000070096
Drug	dimethylpyridine	AOC2 AOC3	1.93e-04	4	130	2	CID000011420
Drug	4-Di	AOC2 PTGER4 AOC3	1.93e-04	20	130	3	CID000005227
Disease	primary autosomal recessive microcephaly 2 with or without cortical malformations (implicated_via_orthology)	MAPKBP1 WDR62	1.81e-05	2	126	2	DOID:0070293 (implicated_via_orthology)
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	1.79e-04	5	126	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	2.68e-04	6	126	2	C0334488
Disease	Ovarian Cysts	PTGER4 IHH MADCAM1	4.50e-04	35	126	3	C0029927
Disease	Corpus Luteum Cyst	PTGER4 IHH MADCAM1	4.50e-04	35	126	3	C0010093
Disease	lipid measurement, high density lipoprotein cholesterol measurement	MAP1A APOA5 OBSL1 RRBP1 SBF2 BCAM MAPKBP1	5.57e-04	330	126	7	EFO_0004529, EFO_0004612
Disease	albuminuria	PHC2 SBF2 MAPKBP1 BAHCC1	7.18e-04	94	126	4	EFO_0004285
Disease	Down syndrome (implicated_via_orthology)	DYRK1B DYRK3	1.83e-03	15	126	2	DOID:14250 (implicated_via_orthology)
Disease	immature granulocyte count	MARK4 PKN3	2.36e-03	17	126	2	EFO_0803542
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	APOA5 OBSL1 RRBP1 SBF2 BCAM MAPKBP1	2.38e-03	315	126	6	EFO_0004612, EFO_0008591
Disease	platelet crit	SCFD2 MAP1A MAP3K14 ZNF318 GPATCH8 RRBP1 KANSL1 TESK2 MARK4 CHRD PKN3	2.60e-03	952	126	11	EFO_0007985
Disease	family history of Alzheimer’s disease	MARK4 BCAM ALPK2	3.52e-03	71	126	3	EFO_0009268
Disease	vitiligo (is_implicated_in)	NLRP1 C4A	3.60e-03	21	126	2	DOID:12306 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
NSHPPRALPGLDALV	BAHCC1	1281	Q9P281
ALAHRAATAARPPAP	AKT1S1	66	Q96B36
LDLLAPPGSPVRNAH	CTC1	511	Q2NKJ3
GSPHPAIARLTVAAP	C4B	451	P0C0L5
PELAPSEIAALAHSP	ALPK2	1286	Q86TB3
AAPSIPLHILDFRAP	ADGRF4	111	Q8IZF3
RSVAPHAPASPARLS	APOA5	211	Q6Q788
SLLPHQDSVPPASAR	AMBRA1	321	Q9C0C7
PHSLTPVAQADPLVR	CAPRIN1	341	Q14444
RVLTPPHDVDSLPHL	CAMSAP3	796	Q9P1Y5
APAPQHPAASALRTR	DYRK1B	581	Q9Y463
HRVPETQPLAPSLAE	ADAMTS7	1386	Q9UKP4
KAAALAHLDRGSPPP	AOC3	106	Q16853
LGPAIPAVSPSAHLA	NKD1	371	Q969G9
PAVSPSAHLAASPAL	NKD1	376	Q969G9
PKDAASVRATHPIPA	RANBP9	196	Q96S59
APSPARPFLKDLHAR	MTCL1	41	Q9Y4B5
LLVAPPLPAADAAHE	NCLN	31	Q969V3
VPPAHGRLSVPASLD	KIAA1549	521	Q9HCM3
PVHLPVVPDGRLSAA	ABI3	191	Q9P2A4
PTRAHPTLQAPSLED	ARHGEF17	991	Q96PE2
PKAAALAHLDRGSPP	AOC2	101	O75106
APPERIVHPAARSLD	OBSL1	1076	O75147
LHVPAKPPRAAAAAA	CASKIN1	1336	Q8WXD9
HGAELRLVPRASPPA	FGFBP3	141	Q8TAT2
LAVPPNPRTLVHAAV	LRRN4CL	186	Q8ND94
RAALPPAAPLSELHA	LRP11	36	Q86VZ4
DDTHPPASLRLLPQV	MADCAM1	351	Q13477
ALALAPGPPTRTRHD	MAP1A	2201	P78559
HIRQPDLSSIAVPPD	MGAT1	161	P26572
IQAELSPAHDRRPLP	NUDT22	21	Q9BRQ3
SRDSAPSPVPHELVI	DNAAF2	271	Q9NVR5
LEVADHAFPPPRTAL	SBF2	331	Q86WG5
LAEDEPAAAHLLPSP	KIF26B	1836	Q2KJY2
PARPVLLLHAADSEA	IL17RE	486	Q8NFR9
DPRAAPLLALLHAAP	IL17RE	571	Q8NFR9
SAALAPATPALQPIH	GPATCH8	1346	Q9UKJ3
RLQDAVLGAAHPVPP	PDCD2L	166	Q9BRP1
PHTPPEAAAGRLLLV	PDE3B	186	Q13370
HPAASPALPRLSDFR	PTGER4	241	P35408
RIAVPSPLDAPQLLH	NLRP1	1366	Q9C000
LIVHLLAPNPAERPS	PLK5	41	Q496M5
ELHSAPLTPVARDTP	KANSL1	996	Q7Z3B3
PRIPAEANPLADHVS	MARCHF5	191	Q9NX47
EHAAFLRALGRPPAP	ASIC3	121	Q9UHC3
AHSALGIPLPRSVAP	ARMC7	181	Q9H6L4
AASTPAPNLPRHISL	MVB12B	211	Q9H7P6
AASAQSLHPVLREPP	POU3F4	156	P49335
ALPGPPHSALILDVA	METTL27	61	Q8N6F8
AVTLHSAPPVLPADS	MOGS	71	Q13724
RAVHANPPTLLLPVA	MOGS	506	Q13724
PVTRASLENVHPPIA	CBLL1	196	Q75N03
IELPNAEPRALSPAH	KIR2DL4	331	Q99706
DAAHPGRSVVPALLP	ALPP	506	P05187
VAVLRAKRAPEAHPP	CEMP1	201	Q6PRD7
PPTIDPSVLEALAAH	IGSF22	601	Q8N9C0
PLAVLPFSDPAHALS	KLHL21	6	Q9UJP4
EAPAHLVPLALAPPA	DOC2A	51	Q14183
TLAHEAAPLPAGRPR	MARK4	596	Q96L34
VAEPQAHAPIRVSPL	MAPKBP1	1271	O60336
LRLLQRPPEEPAAHA	INHA	246	P05111
RSRPAQLHVLVPPEA	KIRREL2	111	Q6UWL6
LSSLNLAVPPPRFHD	EPS15	91	P42566
HPDAQAEVRLSVPPL	BCAM	26	P50895
PAPLDLSHVRLTPAQ	RYR1	966	P21817
TLPRLPHDVVPADNR	RYR1	1406	P21817
AAVAAARPRPPTEHA	PRRT3	696	Q5FWE3
DPSARLTPAQALRHP	DYRK3	506	O43781
GSPHPAIARLTVAAP	C4A	451	P0C0L4
NPDRPTHLSLVSAPE	DHX8	366	Q14562
ETQDPPRRLALTPAH	IHH	261	Q14623
APPPLAAALAHEAVS	PPM1F	71	P49593
SRPLDHAQPPSSLVI	PDLIM1	176	O00151
PPAPHSLLTARQQAA	PKN3	861	Q6P5Z2
PPPAERAHAALAAAL	INSM1	56	Q01101
HAGVALAKPLPRTPE	MAP3K14	156	Q99558
LHIRPAPSDNLPLVD	NOG	31	Q13253
PPAAFEPHAALLGRA	ONECUT3	241	O60422
DAQLEPAHISPAIPV	OPRK1	46	P41145
PLARRHLPQSPDTEA	NUTM2A	341	Q8IVF1
PLARRHLPQSPDTEA	NUTM2B	341	A6NNL0
PLARRHLPQSPDTEA	NUTM2E	341	B1AL46
RLLQARAAPAEAPPH	GRIN3B	1021	O60391
LDAVPPDHSPRARSV	RTKN	521	Q9BST9
VSPHPDAFPSLRALI	VARS1	6	P26640
ALPSHPADSPVILQL	STK11IP	61	Q8N1F8
FLAEAPTALVPHSPL	SFI1	1046	A8K8P3
SAHHDIPALSPLLPE	SEZ6L	91	Q9BYH1
PHLSTENPALVPDAL	PRUNE2	2271	Q8WUY3
RDPLVQLPHPAALIS	TBC1D25	521	Q3MII6
PRILAFLHPPSLSEA	HIF3A	386	Q9Y2N7
ATRHPQSPLSADLPD	HIF3A	436	Q9Y2N7
RVSAAVLPLVHPLPE	NCOR1	121	O75376
ALASVPVALADPHRP	FGD1	316	P98174
RINLAAATHSAPPFP	PSD4	886	Q8NDX1
PPPLSDHIRNAADIS	SLC5A4	16	Q9NY91
LPRPDAFHILRDPVS	SLC5A9	261	Q2M3M2
EVALPPLPAGLHRIS	PKHD1	1161	P08F94
AEVFHVPLLLAPVAP	SCFD2	151	Q8WU76
PLSHATVPQSPARAA	SNRK	381	Q9NRH2
APVAPLPRGAFAVAH	KBTBD11	436	O94819
FSRAPVSALPLAPNH	STX5	211	Q13190
EHLVASRTPELPPSA	TDGF1	156	P13385
AVLVSDPPLSPHTNR	ACTL7A	166	Q9Y615
LAGLLRAHTSPAPAP	ARAP1	61	Q96P48
HDTLPVPLAGALVLP	CHRD	531	Q9H2X0
ERLFPRLPPASVDHV	C15orf39	851	Q6ZRI6
AASFAHLLNPAPPAR	CNOT11	146	Q9UKZ1
NPSERLPLAQVSAHP	AURKB	311	Q96GD4
RAPALPSEARAPHAS	TNRC18	2066	O15417
SRTVPAVAAHPLIAP	PHC2	311	Q8IXK0
ASRGALPARALDPHP	XYLT1	111	Q86Y38
ELRSAEPAPADSRHP	ZFHX2	1156	Q9C0A1
HDPAPNVTVLLREPV	RRBP1	86	Q9P2E9
AALDAAPSHPVPADL	SLC27A5	266	Q9Y2P5
APSHPVPADLRAGIT	SLC27A5	271	Q9Y2P5
PAEPHSLAPELQAQR	WDR97	1406	A6NE52
SDPGLRVPPAARAHL	ARHGAP23	226	Q9P227
HSPPVNRALTPAATL	STAMBPL1	241	Q96FJ0
NLSPPADSRIHVPAS	ZNF592	571	Q92610
VPVAASLPLSHAVIP	ZNRF4	16	Q8WWF5
HPDLASLAPLEIVPF	ARHGAP31	746	Q2M1Z3
PANSRLPPHLIALDS	RALGAPB	1126	Q86X10
HAPDAFPRIAPIRAA	SOCS7	351	O14512
SLAPAGVIRVPAHRP	TLX3	81	O43711
PTLDPRLHRAATAGP	ZC3H4	1006	Q9UPT8
FPAPSPVEESALRLH	WDR62	1321	O43379
PVLPELAFPSSEHRR	WASHC2A	981	Q641Q2
ASERPLSPGAHVPLL	ZNF831	241	Q5JPB2
IPPFRASALPAAQAH	TESK2	496	Q96S53
PPSPAHLAALSVAVI	TUT4	346	Q5TAX3
REANPVPPTHAFLRL	VWA7	811	Q9Y334
RHFPPAVIEASAAPS	PJA2	676	O43164
PSAPIRLPHTAALSQ	ZNF318	746	Q5VUA4
EHLVASRTPELPPSA	TDGF1P3	156	P51864
VRLPPAAAEHSPQTA	HIVEP1	2331	P15822
SEKAAHLLALGPPRP	ZFTA	481	C9JLR9
HLRAPHPPVADVSLA	ZBTB3	256	Q9H5J0
PHQELPRALPAAAAT	LIME1	121	Q9H400