Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium/calmodulin-dependent protein kinase activity	CAMK1G CAMK1 MAPKAPK2	1.95e-05	27	39	3	GO:0004683
GeneOntologyMolecularFunction	sterol ester esterase activity	LCAT LDAH	7.76e-05	7	39	2	GO:0004771
GeneOntologyMolecularFunction	actin filament binding	FLNA FLNB CAPZA3 CNN1	9.79e-04	227	39	4	GO:0051015
GeneOntologyMolecularFunction	calmodulin binding	CAMK1G CAMK1 MAPKAPK2 CNN1	1.03e-03	230	39	4	GO:0005516
GeneOntologyMolecularFunction	cytoskeletal protein binding	TMEM67 FLNA FLNB CAPZA3 LYN CNN1 KRIT1 CAPN10	1.10e-03	1099	39	8	GO:0008092
HumanPheno	Accessory carpal bones	FLNA FLNB	7.02e-06	2	14	2	HP:0004232
HumanPheno	Bipartite calcaneus	FLNA FLNB	7.02e-06	2	14	2	HP:0008127
HumanPheno	Radial bowing	TMEM67 FLNA FLNB	4.14e-05	26	14	3	HP:0002986
HumanPheno	Abnormal shape of the radius	TMEM67 FLNA FLNB	4.14e-05	26	14	3	HP:0045008
HumanPheno	Spondylolysis	FLNA FLNB	1.05e-04	6	14	2	HP:0003304
HumanPheno	Bowed forearm bones	TMEM67 FLNA FLNB	1.12e-04	36	14	3	HP:0003956
HumanPheno	Broad phalanges of the thumb	FLNA FLNB	1.95e-04	8	14	2	HP:0009651
HumanPheno	Bowing of the arm	TMEM67 FLNA FLNB	2.19e-04	45	14	3	HP:0006488
Domain	IG_FLMN	FLNA FLNB	1.80e-04	10	38	2	SM00557
Domain	Filamin	FLNA FLNB	2.19e-04	11	38	2	PF00630
Domain	Filamin/ABP280_rpt	FLNA FLNB	2.19e-04	11	38	2	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNA FLNB	2.19e-04	11	38	2	IPR017868
Domain	FILAMIN_REPEAT	FLNA FLNB	2.19e-04	11	38	2	PS50194
Domain	CH	FLNA FLNB CNN1	3.11e-04	65	38	3	SM00033
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	CAMK1G CAMK1 MAPKAPK2	3.71e-04	69	38	3	IPR020636
Domain	CH	FLNA FLNB CNN1	3.87e-04	70	38	3	PF00307
Domain	-	FLNA FLNB CNN1	4.04e-04	71	38	3	1.10.418.10
Domain	CH	FLNA FLNB CNN1	4.38e-04	73	38	3	PS50021
Domain	CH-domain	FLNA FLNB CNN1	4.74e-04	75	38	3	IPR001715
Domain	Actinin_actin-bd_CS	FLNA FLNB	9.93e-04	23	38	2	IPR001589
Domain	ACTININ_2	FLNA FLNB	9.93e-04	23	38	2	PS00020
Domain	ACTININ_1	FLNA FLNB	9.93e-04	23	38	2	PS00019
Domain	LIPASE_SER	LCAT LDAH	1.27e-03	26	38	2	PS00120
Domain	-	FAP LCAT LDAH	1.81e-03	119	38	3	3.40.50.1820
Domain	AB_hydrolase	FAP LCAT LDAH	1.81e-03	119	38	3	IPR029058
Domain	Protein_kinase_ATP_BS	CAMK1G CAMK1 LYN MAPKAPK2	7.15e-03	379	38	4	IPR017441
Domain	PROTEIN_KINASE_ATP	CAMK1G CAMK1 LYN MAPKAPK2	1.37e-02	459	38	4	PS00107
Pathway	BIOCARTA_MITR_PATHWAY	CAMK1G CAMK1	3.52e-05	5	27	2	M22065
Pathway	BIOCARTA_CACAM_PATHWAY	CAMK1G CAMK1	1.26e-04	9	27	2	M3412
Pathway	WP_NPHP1_DELETION_SYNDROME	FLNA FLNB	1.92e-04	11	27	2	M48099
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY	CAMK1G CAMK1	3.17e-04	14	27	2	M47386
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY	CAMK1G CAMK1	3.17e-04	14	27	2	M47388
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CAMK_SIGNALING_PATHWAY	CAMK1G CAMK1	3.65e-04	15	27	2	M47385
Pathway	BIOCARTA_PGC1A_PATHWAY	CAMK1G CAMK1	3.65e-04	15	27	2	M15181
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PLCG_CAMK_SIGNALING_PATHWAY	CAMK1G CAMK1	4.72e-04	17	27	2	M47387
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_CAMK_SIGNALING_PATHWAY	CAMK1G CAMK1	5.92e-04	19	27	2	M47957
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP2B3_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CAMK1G CAMK1	8.72e-04	23	27	2	M47512
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_CACNA1D_H_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CAMK1G CAMK1	9.50e-04	24	27	2	M47509
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KCNJ5_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CAMK1G CAMK1	1.03e-03	25	27	2	M47510
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP1A1_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CAMK1G CAMK1	1.03e-03	25	27	2	M47511
Pathway	BIOCARTA_HDAC_PATHWAY	CAMK1G CAMK1	1.03e-03	25	27	2	M1547
Pathway	KEGG_MEDICUS_REFERENCE_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY	CAMK1G CAMK1	1.29e-03	28	27	2	M47508
Pubmed	Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.	FLNA FLNB	1.23e-06	2	39	2	21325628
Pubmed	Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome.	FLNA FLNB	1.23e-06	2	39	2	17635842
Pubmed	Structural and functional aspects of filamins.	FLNA FLNB	1.23e-06	2	39	2	11336782
Pubmed	The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.	FLNA FLNB	1.23e-06	2	39	2	33649519
Pubmed	GPIbα regulates platelet size by controlling the subcellular localization of filamin.	FLNA FLNB	3.67e-06	3	39	2	22174152
Pubmed	TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation.	TMEM67 FLNA	3.67e-06	3	39	2	32156598
Pubmed	Filamins as integrators of cell mechanics and signalling.	FLNA FLNB	3.67e-06	3	39	2	11252955
Pubmed	Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading.	FLNA FLNB	3.67e-06	3	39	2	28175289
Pubmed	Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.	FLNA FLNB	3.67e-06	3	39	2	12393796
Pubmed	A meckelin-filamin A interaction mediates ciliogenesis.	TMEM67 FLNA	3.67e-06	3	39	2	22121117
Pubmed	Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.	FLNA FLNB	3.67e-06	3	39	2	11153914
Pubmed	Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation.	FLNA FLNB	3.67e-06	3	39	2	38989458
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	CAMK1 LYN MAPKAPK2 KRIT1 CAPN10 BRWD1	6.08e-06	410	39	6	25814554
Pubmed	Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth.	CAMK1G CAMK1	7.34e-06	4	39	2	17056143
Pubmed	The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.	FLNA FLNB	7.34e-06	4	39	2	11739414
Pubmed	Interaction of presenilins with the filamin family of actin-binding proteins.	FLNA FLNB	7.34e-06	4	39	2	9437013
Pubmed	Structural interaction and functional regulation of polycystin-2 by filamin.	FLNA FLNB	7.34e-06	4	39	2	22802962
Pubmed	HIV infection of T cells: actin-in and actin-out.	FLNA FLNB	1.22e-05	5	39	2	19366992
Pubmed	Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.	FLNA FLNB	1.22e-05	5	39	2	12006559
Pubmed	Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.	FLNA FLNB	1.22e-05	5	39	2	17360453
Pubmed	ASB2 targets filamins A and B to proteasomal degradation.	FLNA FLNB	1.83e-05	6	39	2	18799729
Pubmed	Vector-capping: a simple method for preparing a high-quality full-length cDNA library.	FLNA FLNB	1.83e-05	6	39	2	16106752
Pubmed	The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.	FLNA FLNB	2.56e-05	7	39	2	16076904
Pubmed	MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly.	FLNA FLNB	3.42e-05	8	39	2	34131310
Pubmed	MEKK4 signaling regulates filamin expression and neuronal migration.	FLNA FLNB	3.42e-05	8	39	2	17145501
Pubmed	Filamin B mutations cause chondrocyte defects in skeletal development.	FLNA FLNB	3.42e-05	8	39	2	17510210
Pubmed	Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.	FLNA FLNB	4.39e-05	9	39	2	11807098
Pubmed	Widespread macromolecular interaction perturbations in human genetic disorders.	ALG8 FLNA RBM12 ADAMTSL4 KRIT1 ASPA	4.71e-05	590	39	6	25910212
Pubmed	Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.	FLNA FLNB	5.48e-05	10	39	2	24436304
Pubmed	Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.	FLNA FLNB	6.70e-05	11	39	2	36579465
Pubmed	Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway.	FLNA FLNB	1.46e-04	16	39	2	27789627
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	CAPZA3 BRWD1	1.46e-04	16	39	2	29878059
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	FLNA FLNB	1.85e-04	18	39	2	12119179
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	FAP CPB2 LCAT ADAMTSL4	1.95e-04	257	39	4	16335952
Pubmed	Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method.	FLNA FLNB	2.79e-04	22	39	2	18487259
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	FLNA FLNB FAP CNN1	2.90e-04	285	39	4	21423176
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	FLNA FAP EGFL8 LYN CNN1 QSOX2	3.06e-04	832	39	6	36724073
Pubmed	HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.	FLNA FLNB	5.95e-04	32	39	2	27114546
Pubmed	A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.	FLNA FLNB	6.72e-04	34	39	2	12577067
Pubmed	eXPRESSION: an in silico tool to predict patterns of gene expression.	LCAT GNMT	7.12e-04	35	39	2	15939374
Pubmed	Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.	FLNA FLNB	9.77e-04	41	39	2	19805454
Pubmed	HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.	FLNA FLNB	9.77e-04	41	39	2	24614889
Pubmed	Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.	FLNA FLNB	9.77e-04	41	39	2	18157088
Pubmed	Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis.	FLNA FLNB	1.07e-03	43	39	2	27664421
Interaction	GP1BA interactions	FLNA FLNB LYN	1.62e-05	27	37	3	int:GP1BA
Cytoband	3p25.3	TATDN2 CAMK1	6.80e-04	45	39	2	3p25.3
Disease	distal muscular dystrophy 4 (implicated_via_orthology)	FLNA FLNB	4.84e-06	3	38	2	DOID:0111190 (implicated_via_orthology)
Disease	myofibrillar myopathy 5 (implicated_via_orthology)	FLNA FLNB	4.84e-06	3	38	2	DOID:0080096 (implicated_via_orthology)
Disease	Cystic Kidney Diseases	TMEM67 ALG8	8.82e-05	11	38	2	C1691228
Disease	osteochondrodysplasia (is_implicated_in)	FLNA FLNB	2.72e-04	19	38	2	DOID:2256 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YPKLGYVIYSRSVLC	CAPZA3	281	Q96KX2
ESYSQPVYKPYLTLC	EGFL8	51	Q99944
PLVVQARLCVYPYYT	ADAMTSL4	1041	Q6UY14
CLLPAGTYKVVPSTY	CAPN10	616	Q9HC96
KYYPSTRGLTYTVLP	GKN3P	106	P0CG01
FYGYQVIPGSVCLKY	RBM12	876	Q9NTZ6
KLGVSSVPSCYLIYP	QSOX2	251	Q6ZRP7
KYFYITPGICPSLST	PAXIP1	976	Q6ZW49
GVLLYYVPPVCIYLQ	OR10S1	261	Q8NGN2
VIMYILLCGYPPFYS	MAPKAPK2	251	P49137
KRYAPGLPCDVYTYL	LRRC17	46	Q8N6Y2
TCKVSYFPTVPGVYI	FLNB	2056	O75369
VGYPLYTYGSICIIA	FAM205C	11	A6NFA0
TKYTYTPGCPIFYCL	KRIT1	121	O00522
YKPGQTYIPCYFIHV	GNMT	276	Q14749
GVITYILLCGYPPFY	CAMK1G	206	Q96NX5
VIAYILLCGYPPFYD	CAMK1	206	Q14012
PFYTLQKPTCGYLYR	GUCA1ANB	91	X6R8D5
TYGFLLPERYIKPTC	CPB2	391	Q96IY4
GLPKVCLYPAVSAVY	FBXO45	256	P0C2W1
YIPLCPGAYTVTIKY	FLNA	1221	P21333
LCTYPKYCTVVAYPT	BRWD1	1191	Q9NSI6
YYYTGPKTPFVLVVA	MARVELD2	246	Q8N4S9
ILLYEIVTYGKIPYP	LYN	431	P07948
PITYLPVCGSDYITY	SPINK7	46	P58062
YCLYGVGLPTPRTYI	LCAT	336	P04180
CKSTYYQPICYIFKP	KRTAP29-1	201	A8MX34
PSYIAPYSCILRYAV	TMEM67	721	Q5HYA8
GCPPKYAKTLYLLYA	XAB2	586	Q9HCS7
CFTGSYPVIEPLLKY	TATDN2	656	Q93075
RLYFAPKVLTPYCYT	FASTKD3	551	Q14CZ7
AIFVPSYGCYAKPVK	SMCR8	751	Q8TEV9
KYPFIPLLLTSVYCA	ALG8	486	Q9BVK2
HYIKTSLAPLPCYVY	ASPA	141	P45381
PCYVYLIEHPSLKYA	ASPA	151	P45381
YGLPRQVYDPKYCLT	CNN1	261	P51911
YYALVCYGPGIPIST	FAP	461	Q12884
IVCVYGYSLFIYIPT	YIPF1	201	Q9Y548
PTIYKCPYQGCTAVY	ZNF276	431	Q8N554
VGLLYTYYTKPDGCT	SERINC3	221	Q13530
RLPITGLYNKSPYYC	ZNF526	561	Q8TF50
YVTGYLLLKPCPETI	LDAH	191	Q9H6V9