Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cardiac muscle adaptation	MYH6 MYH7 HEY2 OGA	3.24e-06	43	49	4	GO:0014887
GeneOntologyBiologicalProcess	sarcomere organization	MYH6 MYH7 AKAP13 PRKD1	1.16e-05	59	49	4	GO:0045214
GeneOntologyBiologicalProcess	striated muscle adaptation	MYH6 MYH7 HEY2 OGA	2.71e-05	73	49	4	GO:0014888
GeneOntologyBiologicalProcess	myofibril assembly	MYH6 MYH7 AKAP13 PRKD1	5.17e-05	86	49	4	GO:0030239
GeneOntologyBiologicalProcess	striated muscle cell development	MYH6 MYH7 AKAP13 PRKD1	5.92e-05	89	49	4	GO:0055002
GeneOntologyBiologicalProcess	cardiac muscle hypertrophy in response to stress	MYH6 MYH7 HEY2	1.36e-04	42	49	3	GO:0014898
GeneOntologyBiologicalProcess	muscle hypertrophy in response to stress	MYH6 MYH7 HEY2	1.36e-04	42	49	3	GO:0003299
GeneOntologyBiologicalProcess	muscle cell differentiation	MYH6 MYH7 HEY2 AKAP13 TSC1 PRKD1 DNMT1	2.42e-04	531	49	7	GO:0042692
GeneOntologyBiologicalProcess	actomyosin structure organization	MYH6 MYH7 AKAP13 TSC1 PRKD1	2.52e-04	239	49	5	GO:0031032
GeneOntologyBiologicalProcess	muscle system process	MYH6 MYH7 HEY2 AKAP13 PRKD1 GNAO1 OGA	2.90e-04	547	49	7	GO:0003012
GeneOntologyBiologicalProcess	striated muscle cell differentiation	MYH6 MYH7 HEY2 AKAP13 TSC1 PRKD1	3.14e-04	391	49	6	GO:0051146
GeneOntologyBiologicalProcess	cardiac muscle hypertrophy	MYH6 MYH7 HEY2 AKAP13	3.59e-04	142	49	4	GO:0003300
GeneOntologyBiologicalProcess	muscle cell development	MYH6 MYH7 HEY2 AKAP13 PRKD1	3.65e-04	259	49	5	GO:0055001
GeneOntologyBiologicalProcess	ventricular cardiac muscle tissue morphogenesis	MYH6 MYH7 HEY2	3.73e-04	59	49	3	GO:0055010
GeneOntologyBiologicalProcess	striated muscle hypertrophy	MYH6 MYH7 HEY2 AKAP13	3.99e-04	146	49	4	GO:0014897
GeneOntologyBiologicalProcess	muscle hypertrophy	MYH6 MYH7 HEY2 AKAP13	4.20e-04	148	49	4	GO:0014896
GeneOntologyBiologicalProcess	regulation of sarcomere organization	AKAP13 PRKD1	4.24e-04	13	49	2	GO:0060297
GeneOntologyBiologicalProcess	negative regulation of vascular associated smooth muscle cell differentiation	HEY2 DNMT1	4.24e-04	13	49	2	GO:1905064
GeneOntologyBiologicalProcess	cellular component assembly involved in morphogenesis	MYH6 MYH7 AKAP13 PRKD1	5.12e-04	156	49	4	GO:0010927
GeneOntologyBiologicalProcess	cellular anatomical entity morphogenesis	MYH6 MYH7 AKAP13 PRKD1	5.12e-04	156	49	4	GO:0032989
GeneOntologyBiologicalProcess	muscle filament sliding	MYH6 MYH7	5.69e-04	15	49	2	GO:0030049
GeneOntologyBiologicalProcess	muscle adaptation	MYH6 MYH7 HEY2 OGA	6.18e-04	164	49	4	GO:0043500
GeneOntologyBiologicalProcess	ventricular cardiac muscle tissue development	MYH6 MYH7 HEY2	7.84e-04	76	49	3	GO:0003229
GeneOntologyBiologicalProcess	heart process	MYH6 MYH7 HEY2 AKAP13 GNAO1	8.12e-04	309	49	5	GO:0003015
GeneOntologyBiologicalProcess	cardiac muscle tissue morphogenesis	MYH6 MYH7 HEY2	8.15e-04	77	49	3	GO:0055008
GeneOntologyBiologicalProcess	cardiac muscle cell differentiation	MYH6 HEY2 AKAP13 TSC1	8.22e-04	177	49	4	GO:0055007
GeneOntologyBiologicalProcess	adult heart development	MYH6 MYH7	8.26e-04	18	49	2	GO:0007512
GeneOntologyBiologicalProcess	actin-myosin filament sliding	MYH6 MYH7	8.26e-04	18	49	2	GO:0033275
GeneOntologyBiologicalProcess	muscle structure development	MYH6 MYH7 HEY2 SMARCB1 AKAP13 TSC1 PRKD1 DNMT1	8.61e-04	858	49	8	GO:0061061
GeneOntologyBiologicalProcess	regulation of skeletal muscle contraction	MYH7 PRKD1	1.02e-03	20	49	2	GO:0014819
GeneOntologyBiologicalProcess	cardiac muscle tissue development	MYH6 MYH7 HEY2 AKAP13 TSC1	1.05e-03	327	49	5	GO:0048738
MousePheno	increased uterus leiomyoma incidence	RINT1 TSC1	2.15e-05	3	38	2	MP:0003570
MousePheno	increased cystadenoma incidence	RINT1 TSC1	2.15e-05	3	38	2	MP:0013751
MousePheno	increased leiomyoma incidence	RINT1 TSC1	2.15e-05	3	38	2	MP:0003569
Domain	Myosin_N	MYH6 MYH7	6.37e-04	15	47	2	PF02736
Domain	Myosin_N	MYH6 MYH7	6.37e-04	15	47	2	IPR004009
Domain	Myosin_tail_1	MYH6 MYH7	9.24e-04	18	47	2	PF01576
Domain	Myosin_tail	MYH6 MYH7	9.24e-04	18	47	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH6 MYH7	1.03e-03	19	47	2	IPR027401
Domain	-	MYH6 MYH7	1.03e-03	19	47	2	4.10.270.10
Domain	Myosin_head_motor_dom	MYH6 MYH7	4.11e-03	38	47	2	IPR001609
Domain	MYOSIN_MOTOR	MYH6 MYH7	4.11e-03	38	47	2	PS51456
Domain	Myosin_head	MYH6 MYH7	4.11e-03	38	47	2	PF00063
Domain	MYSc	MYH6 MYH7	4.11e-03	38	47	2	SM00242
Domain	Acyl_CoA_acyltransferase	ATE1 OGA	5.73e-03	45	47	2	IPR016181
Domain	CUB	BMP1 MFRP	6.76e-03	49	47	2	PF00431
Domain	CUB	BMP1 MFRP	7.03e-03	50	47	2	SM00042
Domain	-	BMP1 MFRP	7.59e-03	52	47	2	2.60.120.290
Domain	CUB	BMP1 MFRP	7.87e-03	53	47	2	PS01180
Domain	Glycoside_hydrolase_SF	GLA OGA	7.87e-03	53	47	2	IPR017853
Domain	CUB_dom	BMP1 MFRP	9.06e-03	57	47	2	IPR000859
Pubmed	Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification.	MYH6 MYH7 HEY2	3.13e-07	10	49	3	27052172
Pubmed	The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms.	MYH6 MYH7 HEY2	7.44e-07	13	49	3	34838591
Pubmed	Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.	MYH6 MYH7 HEY2	9.46e-07	14	49	3	19084512
Pubmed	Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.	MYH6 MYH7 HEY2	1.18e-06	15	49	3	17468400
Pubmed	Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.	MYH6 MYH7 HEY2	1.45e-06	16	49	3	20007915
Pubmed	Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.	MYH6 MYH7	1.94e-06	2	49	2	21526716
Pubmed	Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.	MYH6 MYH7	1.94e-06	2	49	2	18480046
Pubmed	Murine pulmonary myocardium: developmental analysis of cardiac gene expression.	MYH6 MYH7	1.94e-06	2	49	2	7919499
Pubmed	Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias.	MYH6 MYH7	1.94e-06	2	49	2	34384224
Pubmed	Characterization of human cardiac myosin heavy chain genes.	MYH6 MYH7	1.94e-06	2	49	2	2726733
Pubmed	Human cardiac myosin heavy chain gene mapped within chromosome region 14q11.2----q13.	MYH6 MYH7	1.94e-06	2	49	2	2494889
Pubmed	Human cardiac myosin heavy chain genes and their linkage in the genome.	MYH6 MYH7	1.94e-06	2	49	2	3037493
Pubmed	β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.	MYH6 MYH7	1.94e-06	2	49	2	21778428
Pubmed	Structural organization of the human cardiac alpha-myosin heavy chain gene (MYH6).	MYH6 MYH7	1.94e-06	2	49	2	8307559
Pubmed	Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.	MYH6 MYH7	1.94e-06	2	49	2	2969919
Pubmed	All-atom molecular dynamics simulations of actin-myosin interactions: a comparative study of cardiac α myosin, β myosin, and fast skeletal muscle myosin.	MYH6 MYH7	1.94e-06	2	49	2	24224850
Pubmed	Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.	MYH6 MYH7	1.94e-06	2	49	2	17575272
Pubmed	Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy.	AKAP13 PRKD1	1.94e-06	2	49	2	26192751
Pubmed	Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium.	MYH6 MYH7	1.94e-06	2	49	2	16088376
Pubmed	Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences.	MYH6 MYH7	1.94e-06	2	49	2	1776652
Pubmed	Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.	MYH6 MYH7	1.94e-06	2	49	2	9884344
Pubmed	Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes.	MYH6 MYH7	1.94e-06	2	49	2	12750067
Pubmed	Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.	MYH6 MYH7	1.94e-06	2	49	2	9541509
Pubmed	Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.	MYH6 MYH7	1.94e-06	2	49	2	23580644
Pubmed	E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA.	UBR5 OGA	1.94e-06	2	49	2	38755129
Pubmed	β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.	MYH6 MYH7	1.94e-06	2	49	2	24829265
Pubmed	Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.	MYH6 MYH7	1.94e-06	2	49	2	2036722
Pubmed	Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.	MYH6 MYH7	1.94e-06	2	49	2	25937279
Pubmed	DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells.	GNAO1 DNMT1	1.94e-06	2	49	2	29709639
Pubmed	Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.	MYH6 MYH7	1.94e-06	2	49	2	15621050
Pubmed	Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus.	MYH6 MYH7	5.83e-06	3	49	2	8620598
Pubmed	Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.	MYH6 MYH7	5.83e-06	3	49	2	18362229
Pubmed	Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.	MYH6 MYH7	5.83e-06	3	49	2	1939265
Pubmed	Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.	MYH6 MYH7	5.83e-06	3	49	2	20923879
Pubmed	Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.	MYH6 MYH7	5.83e-06	3	49	2	1694848
Pubmed	Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.	MYH6 MYH7	5.83e-06	3	49	2	18755891
Pubmed	Mutation in myosin heavy chain 6 causes atrial septal defect.	MYH6 MYH7	5.83e-06	3	49	2	15735645
Pubmed	The effects of slow skeletal troponin I expression in the murine myocardium are influenced by development-related shifts in myosin heavy chain isoform.	MYH6 MYH7	5.83e-06	3	49	2	22966157
Pubmed	Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest.	MYH6 MYH7	5.83e-06	3	49	2	11066038
Pubmed	Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.	MYH6 MYH7 HEY2	7.51e-06	27	49	3	21983003
Pubmed	Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.	MYH6 MYH7 HEY2	8.40e-06	28	49	3	15901664
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SZT2 TSR1 TRIM9 ZNF280C KBTBD2 OGA ACAP2	8.95e-06	529	49	7	14621295
Pubmed	Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse.	MYH6 MYH7 HEY2	1.15e-05	31	49	3	16554359
Pubmed	Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.	MYH6 MYH7	1.16e-05	4	49	2	9927321
Pubmed	Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.	MYH6 MYH7	1.16e-05	4	49	2	25900833
Pubmed	Changes in expression of nonmuscle myosin heavy chain isoforms during muscle and nonmuscle tissue development.	MYH6 MYH7	1.16e-05	4	49	2	8482409
Pubmed	SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation.	SZT2 TSC1	1.16e-05	4	49	2	36250465
Pubmed	TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.	TRIM9 NEUROD6	1.16e-05	4	49	2	28701345
Pubmed	A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance.	TRIM9 NEUROD6	1.16e-05	4	49	2	31820781
Pubmed	Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.	MYH6 MYH7	1.16e-05	4	49	2	11815426
Pubmed	Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages.	MYH6 MYH7	1.16e-05	4	49	2	28806941
Pubmed	Murine cardiac progenitor cells require visceral embryonic endoderm and primitive streak for terminal differentiation.	MYH6 MYH7	1.16e-05	4	49	2	9389458
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	URB1 UBR5 TRIM9 PPP1R16B OGA	1.64e-05	225	49	5	12168954
Pubmed	Recruitment of intra- and extracardiac cells into the myocardial lineage during mouse development.	MYH6 MYH7	1.94e-05	5	49	2	12629673
Pubmed	Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.	MYH6 MYH7	1.94e-05	5	49	2	2552320
Pubmed	Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.	MYH6 MYH7	1.94e-05	5	49	2	12933792
Pubmed	Developmental regulation of myosin gene expression in mouse cardiac muscle.	MYH6 MYH7	1.94e-05	5	49	2	2277065
Pubmed	Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling.	MYH6 MYH7	1.94e-05	5	49	2	24091702
Pubmed	Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.	MYH6 MYH7	1.94e-05	5	49	2	17192267
Pubmed	TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.	UBR5 TP53BP1	1.94e-05	5	49	2	22884692
Pubmed	Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.	MYH6 MYH7	2.91e-05	6	49	2	28381556
Pubmed	The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression.	PRKD1 TP53BP1	2.91e-05	6	49	2	17024177
Pubmed	AKAP-Lbc nucleates a protein kinase D activation scaffold.	AKAP13 PRKD1	2.91e-05	6	49	2	15383279
Pubmed	Mammalian TRIM67 Functions in Brain Development and Behavior.	TRIM9 NEUROD6	2.91e-05	6	49	2	29911180
Pubmed	The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.	TRIM9 NEUROD6	2.91e-05	6	49	2	26702829
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ZNF131 RINT1 URB1 UBR5 TSR1 AKAP13 OGA DDX24 TP53BP1 DNMT1	3.54e-05	1487	49	10	33957083
Pubmed	Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity.	MYH6 MYH7	4.07e-05	7	49	2	21126233
Pubmed	Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory.	TRIM9 NEUROD6	4.07e-05	7	49	2	27147649
Pubmed	Novel roles of cardiac-derived erythropoietin in cardiac development and function.	MYH6 MYH7	4.07e-05	7	49	2	38382296
Pubmed	Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.	MYH6 MYH7	4.07e-05	7	49	2	9004034
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH6 MYH7	4.07e-05	7	49	2	16819597
Pubmed	A threshold of GATA4 and GATA6 expression is required for cardiovascular development.	MYH6 MYH7	5.42e-05	8	49	2	16847256
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH6 MYH7	5.42e-05	8	49	2	3864153
Pubmed	A long noncoding RNA protects the heart from pathological hypertrophy.	MYH6 MYH7	5.42e-05	8	49	2	25119045
Pubmed	Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy.	MYH6 MYH7	5.42e-05	8	49	2	28659827
Pubmed	Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development.	MYH6 MYH7	5.42e-05	8	49	2	22553207
Pubmed	Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.	MYH6 MYH7	6.96e-05	9	49	2	26487682
Pubmed	Molecular characterization of the ventricular conduction system in the developing mouse heart: topographical correlation in normal and congenitally malformed hearts.	MYH6 MYH7	6.96e-05	9	49	2	11164852
Pubmed	Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.	MYH7 GLA	6.96e-05	9	49	2	16754800
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	MYH7 GLA TSC1	7.29e-05	57	49	3	23788249
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	URB1 GLA UBR5 TRIM9 ATE1 DNMT1 IPO11	8.52e-05	754	49	7	33060197
Pubmed	Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.	SMARCB1 DNMT1	8.69e-05	10	49	2	15696166
Pubmed	Real-time resolution of point mutations that cause phenovariance in mice.	KBTBD2 TP53BP1	8.69e-05	10	49	2	25605905
Pubmed	Suppression of atrial myosin gene expression occurs independently in the left and right ventricles of the developing mouse heart.	MYH6 MYH7	8.69e-05	10	49	2	10679931
Pubmed	The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.	MYH6 MYH7 HEY2	8.93e-05	61	49	3	27166947
Pubmed	A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.	PRKD1 DNMT1	1.06e-04	11	49	2	24623306
Pubmed	Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival.	MYH6 MYH7	1.06e-04	11	49	2	31286143
Pubmed	The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart.	MYH6 MYH7	1.06e-04	11	49	2	24137001
Pubmed	Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.	MYH6 MYH7	1.06e-04	11	49	2	16374517
Pubmed	The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.	MYH6 MYH7	1.06e-04	11	49	2	20739404
Pubmed	Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.	NEUROD6 TP53BP1	1.06e-04	11	49	2	33087478
Pubmed	Heart defects in connexin43-deficient mice.	MYH6 MYH7	1.06e-04	11	49	2	9486664
Pubmed	TACE is required for fetal murine cardiac development and modeling.	MYH6 MYH7	1.27e-04	12	49	2	14499647
Pubmed	Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality.	MYH6 MYH7	1.27e-04	12	49	2	15169892
Pubmed	Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.	MYH6 MYH7	1.27e-04	12	49	2	17482496
Pubmed	Jumonji, a nuclear protein that is necessary for normal heart development.	MYH6 MYH7	1.27e-04	12	49	2	10807864
Pubmed	CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression.	MYH7 HEY2	1.27e-04	12	49	2	17332425
Pubmed	Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.	MYH6 MYH7	1.27e-04	12	49	2	8424456
Pubmed	Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway.	MYH6 MYH7	1.50e-04	13	49	2	21447557
Pubmed	Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.	MYH6 MYH7	1.50e-04	13	49	2	7628699
Cytoband	Ensembl 112 genes in cytogenetic band chr15q25	RAMAC FSD2 AKAP13	6.80e-04	160	49	3	chr15q25
Cytoband	7p14.3	KBTBD2 NEUROD6	7.65e-04	38	49	2	7p14.3
Cytoband	15q25.2	RAMAC FSD2	9.80e-04	43	49	2	15q25.2
Cytoband	14q12	MYH6 MYH7	1.60e-03	55	49	2	14q12
GeneFamily	Myosin heavy chains	MYH6 MYH7	2.57e-04	15	29	2	1098
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AKAP13 PRKD1 ACAP2	4.28e-03	206	29	3	682
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	MYH6 MYH7 ENOX1 FSD2 AKAP13	2.14e-06	191	49	5	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	droplet-Heart-4Chambers-21m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PROKR2 PPP1R16B IPO11 BIK	4.97e-05	184	49	4	f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	MYH7 ENOX1 FSD2 AKAP13	5.51e-05	189	49	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	Control-T_cells-CD4+_T_cells\|Control / group, cell type (main and fine annotations)	STK10 TTC39C PPP1R16B GNAO1	5.63e-05	190	49	4	0733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	MYH7 ENOX1 FSD2 AKAP13	5.63e-05	190	49	4	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	MYH6 MYH7 FSD2 AKAP13	5.63e-05	190	49	4	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	COVID-19-lung-CD8+_T_cells\|lung / Disease (COVID-19 only), tissue and cell type	STK10 TTC39C PPP1R16B GNAO1	5.98e-05	193	49	4	780e23e2705fc5c1b70e37568b79731ced5038bd
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Trm_Th1/Th17\|Liver / Manually curated celltypes from each tissue	TTC39C PPP1R16B GNAO1 DDX24	6.22e-05	195	49	4	480cc62ee1e5b1aaf6b62be6e5afd7a81236a1b0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STK10 GLA IFI30 AKAP13	6.73e-05	199	49	4	667b8b47a5b388506e3177b46747267fad8024f6
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.73e-05	199	49	4	fbdde57dd88656621801e65ee2818251588f3874
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.73e-05	199	49	4	0d6463e368fd611a17327322413fad145f3c7f32
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.73e-05	199	49	4	036776a03fdd181e51cc655ed99331eec9c63f39
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	dfdfad881c114e1bc9a64b411e1b00fb37cc859b
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	7a9c3f51d4a8fda5f1b7e0be6fcf9c1c92fffe99
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	6b34f2b85d4f83c1270ee151f602cba6f42042ba
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	8474e5d031d25bfb8461d39fa2053da01a6304fc
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	66fb892bda1d29e67a65717e85f2ec221f520b2a
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	02c4169a23e5aaa0d4bfc78b51ba19ce8157dc3e
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	be9a43acc2f926b9433ab3f018b911b03896a924
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	b2c5618aa1ac19423996336795dadb39ea57cda7
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	f7a9d8b99de19e9842422bada348d940e0863645
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	510d84bf7a4621b079e5a7330d25e04508c84a49
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	9ef322486e46e4ff05a8cbe06cf8019e996c94b3
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STK10 TTC39C PPP1R16B GNAO1	6.86e-05	200	49	4	20ffb3436d08042f77800513e6ddb3bbc38ae6fe
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1-Excitatory_Neuron.Slc17a7.Fibcd1-Lypd1_(CA1_Principal_cells_(Anterior))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYH6 MYH7 GPR151	1.09e-04	84	49	3	52d167614afa9b056f2934142d3250fe5e70e806
Disease	Hypertrophic obstructive cardiomyopathy	MYH6 MYH7 HEY2	9.06e-06	25	48	3	C4551472
Disease	Caveolinopathy	MYH6 MYH7	1.55e-05	4	48	2	cv:C5679790
Disease	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1	MYH6 MYH7	1.55e-05	4	48	2	192600
Disease	Cardiomyopathy, Familial Hypertrophic, 1 (disorder)	MYH6 MYH7	1.55e-05	4	48	2	C3495498
Disease	Hypertrophic cardiomyopathy 1	MYH6 MYH7	1.55e-05	4	48	2	cv:C3495498
Disease	Idiopathic hypertrophic subaortic stenosis	MYH6 MYH7	5.41e-05	7	48	2	C0700053
Disease	Obstructive asymmetric septal hypertrophy	MYH6 MYH7	5.41e-05	7	48	2	C0597124
Disease	Cardiomyopathy, Hypertrophic, Familial	MYH6 MYH7	9.26e-05	9	48	2	C0949658
Disease	Hypertrophic Cardiomyopathy	MYH6 MYH7 HEY2	1.11e-04	57	48	3	C0007194
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:0080719 (implicated_via_orthology)
Disease	Muscular dystrophy, limb-girdle, autosomal dominant	MYH6 MYH7	1.16e-04	10	48	2	cv:C5675009
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH6 MYH7	1.16e-04	10	48	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH6 MYH7	1.69e-04	12	48	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH6 MYH7	1.69e-04	12	48	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH6 MYH7	2.00e-04	13	48	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH6 MYH7	2.68e-04	15	48	2	DOID:0050646 (implicated_via_orthology)
Disease	nose morphology measurement, mouth morphology measurement	FBN3 TTLL13	5.34e-04	21	48	2	EFO_0007843, EFO_0007955
Disease	Primary familial hypertrophic cardiomyopathy	MYH6 MYH7	5.86e-04	22	48	2	cv:C0949658
Disease	congenital heart disease (is_implicated_in)	MYH7 PRKD1	6.99e-04	24	48	2	DOID:1682 (is_implicated_in)
Disease	Carcinoma, Pancreatic Ductal	HEY2 DNMT1	6.99e-04	24	48	2	C0887833
Disease	congestive heart failure (biomarker_via_orthology)	MYH6 MYH7 DNMT1	7.12e-04	107	48	3	DOID:6000 (biomarker_via_orthology)
Disease	Limb-girdle muscular dystrophy	MYH6 MYH7	8.21e-04	26	48	2	cv:C0686353
Disease	Primary familial dilated cardiomyopathy	MYH6 MYH7	1.09e-03	30	48	2	cv:C0340427
Disease	Cardiomyopathies	MYH6 MYH7 GLA	1.25e-03	130	48	3	C0878544
Disease	Heart Failure, Diastolic	MYH6 MYH7	1.32e-03	33	48	2	C1135196
Disease	Primary dilated cardiomyopathy	MYH6 MYH7	1.41e-03	34	48	2	cv:C0007193

Protein segments in the cluster

Peptide	Gene	Start	Entry
CPNMAMKEADDDEEV	DNMT1	691	P26358
LEEKEMIFRDMAECS	AKAP13	2376	Q12802
DSCISEKLFMEMAEL	GLA	61	P06280
MKMTVDFEECLKDSP	ACAP2	1	Q15057
FEPGLMMTCEDIDEC	FBN3	2156	Q75N90
KLTFMEMDIESQPEC	BMP1	786	P13497
PMEDFDSLECMEGSD	BIK	41	Q13323
MTDTAEAVPKFEEMF	RAMAC	1	Q9BTL3
MSILEEECMFPKATD	MYH7	531	P12883
MKDFSDVILCMEATE	MFRP	1	Q9BY79
MKRPCEETTSESDMD	HEY2	1	Q9UBP5
ECMFETPERVFVVME	PRKD1	646	Q15139
VMTEDPETGTYKDCM	IPO11	881	Q9UI26
MVFQMPDKDEESRIC	DDX58	521	O95786
EEMMIFIEASSENPC	KBTBD2	266	Q8IY47
MCLVDVPAVAEEFMS	GPR151	186	Q8TDV0
HECMEIVFGTDMKEV	MAGEA13P	151	A6NCF6
EEICFMEDAGEVVMP	PPP4R3C	681	Q6ZMV5
RTSMDEMPIDLCEEE	PPP1R16B	291	Q96T49
KPEEFISEMDMSCEV	ICE2	366	Q659A1
IVCMEEFEDMERSLP	IFI30	146	P13284
QCPEECVMFEDEMSE	DNAH14	561	Q0VDD8
CEDEPMDSTMDDAVA	ATE1	111	O95260
DMVCDDPEAGEMTSE	DDX24	131	Q9GZR7
EMSDDENCDSPTKKM	ENOX1	401	Q8TC92
CMMAALPEDTVVFEK	PAOX	231	Q6QHF9
SMLFTEECDKVRDLM	SZT2	3026	Q5T011
IAESKSPEMSMQEDC	OGA	506	O60502
MEEDFMKPVISIVDE	SCPEP1	341	Q9HB40
ADDEITMMVPVESKF	TAF1L	326	Q8IZX4
METIEEMCHEEKVDF	FSD2	306	A1L4K1
MVCDVVSRMEDTEPF	GNAO1	106	P09471
KLMTPEMFSEILCDD	SMARCB1	211	Q12824
EEECMFPKATDMTFK	MYH6	536	P13533
EMADPELMASTLETC	URB1	2041	O60287
ENLETFEEVVKPMME	TSC1	211	Q92574
DPDMAMEICATDAVD	TSR1	321	Q2NL82
DEMKVPDCAETFMTL	RINT1	471	Q6NUQ1
EMEEMNTSEEEESPC	SPIRE2	416	Q8WWL2
PEVVMCETMKDTPYD	STK10	201	O94804
PMDEDEDMTKTRTFF	PROKR2	36	Q8NFJ6
EMPKKECSEAMEVET	TP53BP1	706	Q12888
MEEMEEELKCPVCGS	TRIM9	1	Q9C026
VIEMLEDEDMPCKDS	ZNF215	126	Q9UL58
NISKMAELFMECEEE	ZNF280C	11	Q8ND82
MEAEETMECLQEFPE	ZNF131	1	P52739
MTFEEEKMQLACDDL	TTC39C	76	Q8N584
SSEKEEDVFMGMVCP	UBR5	1146	O95071
MEPSTCRTMESEEDY	TTLL13	1	A6NNM8
FDESVVMPESQMCRK	NEUROD6	6	Q96NK8