Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of ribosome

RPL3 RPL3L RPL37AP8

7.70e-04183203GO:0003735
GeneOntologyCellularComponentcytosolic large ribosomal subunit

RPL3 RPL3L RPL37AP8

2.35e-0559203GO:0022625
GeneOntologyCellularComponentlarge ribosomal subunit

RPL3 RPL3L RPL37AP8

1.86e-04118203GO:0015934
GeneOntologyCellularComponentcytosolic ribosome

RPL3 RPL3L RPL37AP8

2.16e-04124203GO:0022626
GeneOntologyCellularComponentribosomal subunit

RPL3 RPL3L RPL37AP8

7.99e-04194203GO:0044391
GeneOntologyCellularComponentaxon

HCN4 CNTN4 LGI3 MAPK8IP3 LLGL1

1.26e-03891205GO:0030424
GeneOntologyCellularComponentribosome

RPL3 RPL3L RPL37AP8

2.00e-03267203GO:0005840
GeneOntologyCellularComponentmain axon

LGI3 MAPK8IP3

3.24e-0389202GO:0044304
DomainRibosomal_L3

RPL3 RPL3L

2.63e-063182PF00297
DomainRibosomal_L3

RPL3 RPL3L

2.63e-063182IPR000597
DomainRIBOSOMAL_L3

RPL3 RPL3L

2.63e-063182PS00474
DomainRibosomal_L3_CS

RPL3 RPL3L

2.63e-063182IPR019926
DomainTransl_B-barrel

RPL3 RPL3L

3.04e-0427182IPR009000
DomainLRR_8

ECM2 LGI3

1.16e-02171182PF13855
DomainLeu-rich_rpt_typical-subtyp

ECM2 LGI3

1.24e-02177182IPR003591
DomainLRR_TYP

ECM2 LGI3

1.24e-02177182SM00369
Pubmed

Expression of Muscle-Specific Ribosomal Protein L3-Like Impairs Myotube Growth.

RPL3 RPL3L

3.14e-07220226684695
Pubmed

RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.

RPL3 RPL3L

3.14e-07220237080962
Pubmed

A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region.

RPL3 RPL3L

3.14e-0722028921388
Pubmed

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.

RPL3 RPL3L

3.14e-07220236882085
Pubmed

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.

CYP7A1 ACACA

7.89e-052320226508642
Pubmed

Characterization of the DOT1L network: implications of diverse roles for DOT1L.

NIPBL ACACA

2.54e-044120220431927
Pubmed

Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.

RPL3 RPL3L

3.49e-044820214567916
Pubmed

Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

RPL3 RPL3L

3.49e-044820212962325
Pubmed

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

RPL3 RPL3L RPL37AP8 ACACA

3.96e-0462420433729478
Pubmed

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.

USP15 RPL3 ACACA

4.63e-0426720333417871
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

RPL3 PGM3 ACACA

4.89e-0427220325315684
Cytoband16p13.3

RPL3L MAPK8IP3

5.02e-0324420216p13.3
CytobandEnsembl 112 genes in cytogenetic band chr16p13

RPL3L MAPK8IP3

1.46e-02426202chr16p13
GeneFamilyL ribosomal proteins

RPL3 RPL3L

4.22e-0451112729
CoexpressionGSE6875_WT_VS_FOXP3_KO_TREG_UP

LGI3 LLGL1 PITPNC1 ACACA

1.45e-05200204M6803
CoexpressionGUO_TARGETS_OF_IRS1_AND_IRS2

NIPBL PITPNC1 ACACA

5.35e-0597203M2434
CoexpressionGUO_TARGETS_OF_IRS1_AND_IRS2

NIPBL PITPNC1 ACACA

5.35e-0597203MM1318
Drugmuconomycin A

RPL3 RPL3L

1.54e-057202CID000104830
Drugnitrendipine; Down 200; 10uM; MCF7; HG-U133A

NIPBL PGM3 LLGL1 ACACA

2.41e-05198204336_DN
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; PC3; HG-U133A

NIPBL PGM3 MAPK8IP3 ACACA

2.46e-051992041907_DN
Drugexemestane; Down 200; 0.01uM; MCF7; HG-U133A

SCML2 PGM3 MAPK8IP3 ACACA

2.46e-05199204165_DN
Drugnd-8

RPL3 RPL3L

3.28e-0510202CID000020806
DrugL-364,373

RPL3 RPL3L

4.81e-0512202CID000656755
Diseaseinflammatory biomarker measurement, YKL40 measurement

CNTN4 PITPNC1

5.46e-0451202EFO_0004869, EFO_0004872
Diseasecancer (implicated_via_orthology)

NIPBL PGM3 LLGL1

7.53e-04268203DOID:162 (implicated_via_orthology)
Diseaselipid measurement, lipoprotein measurement

CYP7A1 LLGL1

1.69e-0390202EFO_0004529, EFO_0004732
Diseasefree cholesterol measurement

CYP7A1 LLGL1

2.64e-03113202EFO_0008591
DiseaseIGF-1 measurement

RPL3L CYP7A1 MAPK8IP3

4.16e-03488203EFO_0004627
DiseaseCraniofacial Abnormalities

CNTN4 NIPBL

4.96e-03156202C0376634
DiseaseParoxysmal atrial fibrillation

HCN4 RPL3L

4.96e-03156202C0235480
DiseasePersistent atrial fibrillation

HCN4 RPL3L

4.96e-03156202C2585653
Diseasefamilial atrial fibrillation

HCN4 RPL3L

4.96e-03156202C3468561
DiseaseAtrial Fibrillation

HCN4 RPL3L

5.21e-03160202C0004238

Protein segments in the cluster

PeptideGeneStartEntry
VMKVPVYCTKTGVKH

PGM3

341

O95394
IQLKHAGKYVCMVQT

CNTN4

566

Q8IWV2
QCAVKLAKMVGYVSA

ACACA

406

Q13085
VVVKNMKIVGLHCSS

CDADC1

91

Q9BWV3
GVQKVALCKYTAQMV

LLGL1

516

Q15334
CGYKNKVHVIQPKTM

MAPK8IP3

1061

Q9UPT6
SQMDVVGQTVCYVHK

FREM1

1456

Q5H8C1
VGQTVCYVHKSKVTV

FREM1

1461

Q5H8C1
LIIKYGMTVVQHCVS

NIPBL

2076

Q6KC79
YQKCHRKTVMTVADQ

MEIKIN

206

A0A087WXM9
KMYFIQHGVVSVLTK

HCN4

631

Q9Y3Q4
GHCLVKGITMYNKAV

ECM2

101

O94769
VFTCKLMGKYVHFIT

CYP7A1

66

P22680
MVKEIEISQHTKYTC

RPL37AP8

26

A6NKH3
SSMKKYCQVIRVIAH

RPL3

151

P39023
YCKVIRVIVHTQMKL

RPL3L

156

Q92901
KYLSHDVVVMTVKLC

SLC38A6

321

Q8IZM9
KIVMSTVCVYVNKHG

SCML2

351

Q9UQR0
SHQPIMCSYKLVTVK

PITPNC1

176

Q9UKF7
GMFVKHCKVEVYLTE

USP15

121

Q9Y4E8
VHCKPMVVDSQLYVV

LGI3

281

Q8N145