Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

1.38e-075493GO:0030156
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

CAD DPYSL5

6.93e-0416492GO:0016812
GeneOntologyMolecularFunctioniron ion binding

CYP11A1 CH25H OGFOD1 OGFOD3

7.29e-04166494GO:0005506
GeneOntologyMolecularFunctionL-ascorbic acid binding

OGFOD1 OGFOD3

1.09e-0320492GO:0031418
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP11A1 CH25H OGFOD1 OGFOD3

1.30e-03194494GO:0016705
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP11A1 CH25H

3.15e-0334492GO:0008395
GeneOntologyMolecularFunctionGTPase activator activity

SGSM1 TBCK RINL ARAP2

4.82e-03279494GO:0005096
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

3.80e-0528493GO:0002177
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

2.36e-0519423MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

3.23e-0521423MP:0008893
DomainSp1_fam

SP8 SP5

2.87e-0410482IPR030450
DomainMetal-dep_hydrolase_composite

CAD DPYSL5

2.87e-0410482IPR011059
DomainAmidohydro_1

CAD DPYSL5

2.87e-0410482PF01979
DomainAmidohydro-rel

CAD DPYSL5

3.51e-0411482IPR006680
DomainPro_4_hyd_alph

OGFOD1 OGFOD3

7.58e-0416482IPR006620
DomainP4Hc

OGFOD1 OGFOD3

7.58e-0416482SM00702
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B

1.06e-0378483PF14604
DomainFE2OG_OXY

OGFOD1 OGFOD3

1.32e-0321482PS51471
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

1.40e-0386483IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

1.40e-0386483PF07653
DomainOxoglu/Fe-dep_dioxygenase

OGFOD1 OGFOD3

1.58e-0323482IPR005123
DomainFN3

RIMBP3 RIMBP3C MYBPHL RIMBP3B

1.69e-03199484PS50853
DomainMetal_Hydrolase

CAD DPYSL5

1.72e-0324482IPR032466
DomainFN3_dom

RIMBP3 RIMBP3C MYBPHL RIMBP3B

2.02e-03209484IPR003961
DomainSH3

RIMBP3 SH3TC1 RIMBP3C RIMBP3B

2.27e-03216484PS50002
DomainSH3

RIMBP3 SH3TC1 RIMBP3C RIMBP3B

2.27e-03216484SM00326
DomainSH3_domain

RIMBP3 SH3TC1 RIMBP3C RIMBP3B

2.43e-03220484IPR001452
DomainTBC

SGSM1 TBCK

7.04e-0349482SM00164
DomainTPR_2

FBXO9 SH3TC1

7.32e-0350482PF07719
DomainTPR_2

FBXO9 SH3TC1

7.32e-0350482IPR013105
Domain-

ZNF419 SP8 ZNF652 SP5 ZNF616 ZBTB11

7.56e-036794863.30.160.60
DomainRabGAP-TBC

SGSM1 TBCK

8.20e-0353482PF00566
Domainzf-C2H2

ZNF419 SP8 ZNF652 SP5 ZNF616 ZBTB11

8.32e-03693486PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF419 SP8 ZNF652 SP5 ZNF616 ZBTB11

8.38e-03694486IPR013087
Domainzf-C2H2_6

ZNF419 ZNF652 ZNF616 ZBTB11

8.53e-03314484PF13912
DomainTBC_RABGAP

SGSM1 TBCK

8.81e-0355482PS50086
DomainRab-GTPase-TBC_dom

SGSM1 TBCK

8.81e-0355482IPR000195
PathwayWP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES

OSBP CYP11A1 CH25H ABCD3

5.56e-05111274M48065
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

1.12e-08450319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

2.79e-08550317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

1.01e-061450317662146
Pubmed

The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.

FUCA1 CNR2

2.02e-0555029261404
Pubmed

Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.

SP8 SP5

5.64e-05850226969725
Pubmed

Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning.

SP8 SP5

7.25e-05950217509151
Pubmed

Lgr4 controls specialization of female gonads in mice.

CYP11A1 SP5

1.32e-041250226333992
Pubmed

Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells.

SP8 SP5

1.32e-041250224475213
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

ERBB3 DPYSL5 NAV1 PKP2 EEF1AKMT2 WDR59 ARAP2

1.56e-0481450723251661
Pubmed

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.

CAD TM9SF1 ABCD3

2.63e-048650325044020
Pubmed

Expression and functional analysis of Dkk1 during early gonadal development.

CYP11A1 SP5

2.72e-041750221654186
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

ERBB3 ABCD3 OGFOD1 MIB2 DBR1 ZBTB11

3.29e-0465050638777146
Pubmed

A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation.

SP8 SP5

3.41e-041950232156757
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

SGSM1 CYP11A1 OGFOD1 SLU7 TRMO MYBPHL ADGRD1 ARAP2

3.66e-04124250830973865
Pubmed

XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes.

ERBB3 CYP11A1

3.79e-042050221466799
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

CAD ABCD3 PKP2 ABT1 ZBTB11

4.20e-0444050534244565
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

SP8 SP5

5.95e-042550215820306
Pubmed

Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos.

SP8 SP5

8.59e-043050231789450
Pubmed

Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.

ERBB3 SP5

9.77e-043250238110169
Pubmed

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.

SP8 SP5

1.04e-033350218480165
Pubmed

Ovarian development in mice requires the GATA4-FOG2 transcription complex.

CYP11A1 SP5

1.24e-033650218927154
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

NAV1 PKP2 ATP13A3 TAF2 ARAP2

1.33e-0356950530639242
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

2.48e-0411150322q11.21
GeneFamilyZinc fingers C2H2-type|Sp transcription factors

SP8 SP5

8.88e-059292755
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF419 SP8 ZNF652 SP5 ZNF616 ZBTB11

8.34e-0471829628
DiseaseLeft ventricular noncompaction

PKP2 MIB2

2.05e-0414452C1960469
Diseasehippocampus molecular layer volume

NUP210L EEF1AKMT2

1.31e-0335452EFO_0009397
Diseasecortical thickness

SP8 ERBB3 DCDC1 NUP210L DPYSL5 NAV1 EEF1AKMT2

1.38e-031113457EFO_0004840
Diseasehippocampal CA4 volume

NUP210L EEF1AKMT2

1.80e-0341452EFO_0009396
Diseasemacrophage migration inhibitory factor measurement

SGSM1 ADGRD1

1.97e-0343452EFO_0008221
DiseaseColorectal Carcinoma

OSBP CAD SH3TC1 ABCD3 CINP

4.18e-03702455C0009402
Diseaserheumatoid arthritis, COVID-19

ERBB3 ABT1

4.32e-0364452EFO_0000685, MONDO_0100096
DiseaseSeizures

CYP11A1 TBCK FUCA1

4.49e-03218453C0036572
Diseaseinterstitial lung disease

NAV1 THSD7B

4.72e-0367452EFO_0004244
Diseaseosteoarthritis

DCDC1 PKP2 THSD7B

4.72e-03222453MONDO_0005178
Diseaseleucine measurement

DCDC1 PKP2

5.58e-0373452EFO_0009770

Protein segments in the cluster

PeptideGeneStartEntry
ESIHFGKYTHQSDVW

ERBB3

881

P21860
HRHAWSTVVGLLYHS

ADGRD1

416

Q6QNK2
THHSVKYFWNDTIHN

ATP13A3

141

Q9H7F0
YIHGHTKLDFTVWHT

ARAP2

1091

Q8WZ64
IYTYGHVLWKAHQHV

CNR2

206

P34972
WYKKFFHHLLHITVL

PGBD4

451

Q96DM1
ITWVYSSHRHPHVVY

RIMBP3B

1011

A6NNM3
ITWVYSSHRHPHVVY

RIMBP3C

1011

A6NJZ7
HWKTGHYTLIHDHSK

OGFOD1

441

Q8N543
TQTEYHIHHGAWTTA

DCDC1

786

M0R2J8
TAHDEYWHAHVDKVT

OGFOD3

221

Q6PK18
YVVLTTKHHEGFTNW

FUCA1

131

P04066
FHATGHHYTWKKVTT

OSBP

566

P22059
HHYTWKKVTTTVHNI

OSBP

571

P22059
KYLHRFTWSHLSEHL

ABT1

146

Q9ULW3
IWIHHSCHITYKSTG

FBXO9

401

Q9UK97
GTTGTHHHAWIIFVF

EEF1AKMT2

236

Q5JPI9
LTRYHHIDSGTHTWL

GPR148

286

Q8TDV2
NLYHFWRETGTHKVH

CYP11A1

61

P05108
DTKSGLWFTVLEHYH

MYBPHL

186

A2RUH7
HLKPTYWFSAHLHVK

DBR1

216

Q9UK59
HHKVPWLYRTFHKVH

CH25H

146

O95992
ATLTGLHYYHQDWSH

DPYSL5

276

Q9BPU6
YTWHSTHHDAVTVEP

NUP210L

66

Q5VU65
TFHPGALTKHHSFWV

MIB2

316

Q96AX9
KLWYHLHTFLEKHST

NAV1

1721

Q8NEY1
VYGKTSHLKAHLRWH

SP5

306

Q6BEB4
HKDPESTQFSHHWYL

NHSL2

626

Q5HYW2
ITWVYSSHRHPHVVY

RIMBP3

1011

Q9UFD9
LHFSIKHPHTLSWEY

TAF2

431

Q6P1X5
IWKFSTYHALGFTHH

SH3TC1

151

Q8TE82
VYGKTSHLKAHLRWH

SP8

366

Q8IXZ3
FTVSHRKSLWKHHEY

ABCD3

621

P28288
LFHTWPTTHFYEVSH

CINP

136

Q9BW66
YHVHVKGTHVWVGLY

COL10A1

601

Q03692
LTTWFGALHHIAHYQ

RINL

496

Q6ZS11
SHVWILFVFHKNGHL

TRMO

81

Q9BU70
HHTRHQTWHYLSKTY

ZBTB11

86

O95625
YSKHSHLAVHWRIHT

ZNF616

446

Q08AN1
HLAVHWRIHTGEKAY

ZNF616

451

Q08AN1
EDVKIHNHTHIWGSY

SLU7

421

O95391
TIWAAKHVSSAHYVL

SGSM1

1076

Q2NKQ1
FTHVFPLHKIFHLWD

TBCK

631

Q8TEA7
FYTEHGVKVTAVDWH

CAD

1351

P27708
YLAAHLSKIHGLDWH

WDR59

186

Q6PJI9
KFTIVWHLKYHTCHN

TMEM87B

86

Q96K49
AHHHSKSWAIEIGYQ

THSD7B

286

Q9C0I4
FTSGKHYWEVDVTHS

TRIM64C

336

A6NLI5
LWSLHEHIKIVHGYA

ZNF652

311

Q9Y2D9
FYSHKSNLIKHWRVH

ZNF419

351

Q96HQ0
SLWAHTELHHAYKKA

PKP2

846

Q99959
KIGLWTHLDFHLEFH

TM9SF1

156

O15321