| GeneOntologyMolecularFunction | DNA-binding transcription factor activity, RNA polymerase II-specific | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF888 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 1.57e-13 | 1412 | 57 | 24 | GO:0000981 |
| GeneOntologyMolecularFunction | RNA polymerase II transcription regulatory region sequence-specific DNA binding | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZNF888 ZNF431 ZNF225 SNAPC3 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 3.20e-13 | 1459 | 57 | 24 | GO:0000977 |
| GeneOntologyMolecularFunction | RNA polymerase II cis-regulatory region sequence-specific DNA binding | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZFP30 ZNF347 ZNF267 ZNF888 ZNF431 ZNF225 SNAPC3 ZNF229 ZNF236 KLF4 ZNF239 | 7.13e-10 | 1244 | 57 | 19 | GO:0000978 |
| GeneOntologyMolecularFunction | cis-regulatory region sequence-specific DNA binding | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZFP30 ZNF347 ZNF267 ZNF888 ZNF431 ZNF225 SNAPC3 ZNF229 ZNF236 KLF4 ZNF239 | 1.02e-09 | 1271 | 57 | 19 | GO:0000987 |
| Domain | zf-C2H2 | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 5.33e-19 | 693 | 55 | 23 | PF00096 |
| Domain | Znf_C2H2/integrase_DNA-bd | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 5.50e-19 | 694 | 55 | 23 | IPR013087 |
| Domain | Znf_C2H2-like | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 AKAP8L ZNF404 ZNF239 | 6.53e-19 | 796 | 55 | 24 | IPR015880 |
| Domain | Znf_C2H2 | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 AKAP8L ZNF404 ZNF239 | 8.46e-19 | 805 | 55 | 24 | IPR007087 |
| Domain | ZnF_C2H2 | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 AKAP8L ZNF404 ZNF239 | 9.22e-19 | 808 | 55 | 24 | SM00355 |
| Domain | ZINC_FINGER_C2H2_2 | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 6.31e-18 | 775 | 55 | 23 | PS50157 |
| Domain | - | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 6.48e-18 | 679 | 55 | 22 | 3.30.160.60 |
| Domain | ZINC_FINGER_C2H2_1 | ZBTB37 ATF7 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 6.68e-18 | 777 | 55 | 23 | PS00028 |
| Domain | KRAB | ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZNF431 ZNF225 ZNF229 ZFP69 ZNF404 | 7.69e-14 | 358 | 55 | 15 | PS50805 |
| Domain | KRAB | ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZNF431 ZNF225 ZNF229 ZFP69 ZNF404 | 7.69e-14 | 358 | 55 | 15 | PF01352 |
| Domain | KRAB | ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZNF431 ZNF225 ZNF229 ZFP69 ZNF404 | 1.19e-13 | 369 | 55 | 15 | SM00349 |
| Domain | KRAB | ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZNF431 ZNF225 ZNF229 ZFP69 ZNF404 | 1.24e-13 | 370 | 55 | 15 | IPR001909 |
| Domain | zf-C2H2_6 | ZNF141 ZNF586 ZNF718 ZFP30 ZNF267 ZBTB47 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 ZNF404 | 9.51e-11 | 314 | 55 | 12 | PF13912 |
| Domain | E-NPP | ENPP1 ENPP4 | 1.77e-04 | 7 | 55 | 2 | IPR024873 |
| Domain | Phosphodiest | ENPP1 ENPP4 | 3.77e-04 | 10 | 55 | 2 | PF01663 |
| Domain | Phosphodiest/P_Trfase | ENPP1 ENPP4 | 3.77e-04 | 10 | 55 | 2 | IPR002591 |
| Domain | Alkaline_phosphatase_core | ENPP1 ENPP4 | 3.75e-03 | 31 | 55 | 2 | IPR017850 |
| Domain | Alkaline_Pase-like_a/b/a | ENPP1 ENPP4 | 3.75e-03 | 31 | 55 | 2 | IPR017849 |
| Domain | - | ENPP1 ENPP4 | 3.75e-03 | 31 | 55 | 2 | 3.40.720.10 |
| Pathway | REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION | ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZFP30 ZNF436 ZNF347 ZNF267 ZNF431 CBX4 ZNF225 SNAPC3 ZNF625 KLF4 ZFP69 | 4.50e-07 | 1387 | 40 | 16 | M734 |
| Pubmed | Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. | ENPP1 ENPP4 | 2.64e-06 | 2 | 57 | 2 | 24338010 |
| Pubmed | Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. | ZNF225 ZNF229 ZNF404 | 4.66e-06 | 20 | 57 | 3 | 12743021 |
| Pubmed | Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. | ENPP1 ENPP4 | 7.91e-06 | 3 | 57 | 2 | 11027689 |
| Pubmed | Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. | ZNF718 ZNF257 ZNF267 EDC4 ZNF229 | 1.21e-05 | 181 | 57 | 5 | 37372979 |
| Pubmed | Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system. | HK2 TEX2 | 7.34e-05 | 8 | 57 | 2 | 10460589 |
| Pubmed | ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. | ZNF28 ZNF718 ZNF257 PPP1R9B ZNF236 AKAP8L | 9.54e-05 | 451 | 57 | 6 | 36168627 |
| Pubmed | Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. | ZBTB37 ATF7 ZNF718 ZNF347 ZNF236 KLF4 ZNF239 | 3.43e-04 | 808 | 57 | 7 | 20412781 |
| Pubmed | Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation. | BAMBI KLF4 | 3.53e-04 | 17 | 57 | 2 | 26992132 |
| Pubmed | Different roles of Runx2 during early neural crest-derived bone and tooth development. | ENPP1 BAMBI | 3.53e-04 | 17 | 57 | 2 | 16813524 |
| Pubmed | Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. | WNT9A FZD10 | 3.53e-04 | 17 | 57 | 2 | 28733458 |
| Pubmed | Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. | ZNF594 ZNF267 | 5.43e-04 | 21 | 57 | 2 | 7865130 |
| Pubmed | Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin. | FZD10 KLF4 | 7.73e-04 | 25 | 57 | 2 | 30220568 |
| Pubmed | 3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19). | WNT9A FZD10 | 1.04e-03 | 29 | 57 | 2 | 18364260 |
| Pubmed | The DNA sequence and biology of human chromosome 19. | ZNF888 ZNF225 ZNF229 ZNF239 | 1.22e-03 | 284 | 57 | 4 | 15057824 |
| Pubmed | PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. | ZNF177 HINT3 ZNF625 | 1.29e-03 | 130 | 57 | 3 | 26598620 |
| Pubmed | Molecular architecture of the developing mouse brain. | WNT9A FZD10 BAMBI | 1.35e-03 | 132 | 57 | 3 | 34321664 |
| Pubmed | Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. | GATM KLF4 | 1.35e-03 | 33 | 57 | 2 | 16618389 |
| Pubmed | WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. | WNT9A FZD10 | 1.52e-03 | 35 | 57 | 2 | 30940800 |
| Cytoband | 16q22.1 | PHAF1 CHTF8 TERB1 EDC4 | 1.12e-05 | 110 | 57 | 4 | 16q22.1 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr16q22 | PHAF1 CHTF8 TERB1 EDC4 | 8.18e-05 | 183 | 57 | 4 | chr16q22 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr19q13 | ZNF586 ZNF28 ZFP30 ZNF347 ZNF888 ZNF225 ZNF229 ZNF404 | 1.08e-04 | 1192 | 57 | 8 | chr19q13 |
| Cytoband | 19q13.31 | ZNF229 ZNF404 | 6.02e-04 | 29 | 57 | 2 | 19q13.31 |
| Cytoband | 19q13.41 | ZNF28 ZNF888 | 4.28e-03 | 78 | 57 | 2 | 19q13.41 |
| Cytoband | 4p16.3 | ZNF141 ZNF718 | 5.06e-03 | 85 | 57 | 2 | 4p16.3 |
| GeneFamily | Zinc fingers C2H2-type|ZF class homeoboxes and pseudogenes | ZBTB37 ZNF594 ZNF141 ZNF586 ZNF28 ZNF718 ZNF257 ZNF177 ZFP30 ZNF436 ZNF347 ZNF267 ZBTB47 ZNF888 ZNF431 ZNF225 ZNF229 ZNF625 ZNF236 KLF4 ZFP69 ZNF404 ZNF239 | 3.73e-23 | 718 | 38 | 23 | 28 |
| Disease | Myocardial Ischemia | HK2 GATM KLF4 | 4.14e-03 | 176 | 54 | 3 | C0151744 |
| Disease | hepatocellular carcinoma (is_implicated_in) | PTPN13 CBX4 KLF4 | 4.48e-03 | 181 | 54 | 3 | DOID:684 (is_implicated_in) |
| Disease | Obesity | HK2 ENPP1 CYB5A | 6.32e-03 | 205 | 54 | 3 | C0028754 |
