Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol-5-phosphate binding

SH3PXD2B SH3PXD2A OBSCN

2.68e-0523513GO:0010314
GeneOntologyMolecularFunctionphosphatidylinositol-4-phosphate binding

SH3PXD2B SH3PXD2A OBSCN

1.06e-0436513GO:0070273
GeneOntologyMolecularFunctioninositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

INPP5K INPP5J

1.33e-047512GO:0052659
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

INPP5K INPP5J

1.33e-047512GO:0034485
GeneOntologyMolecularFunctioninositol-polyphosphate 5-phosphatase activity

INPP5K INPP5J

1.77e-048512GO:0004445
GeneOntologyMolecularFunctioninositol-1,4,5-trisphosphate 5-phosphatase activity

INPP5K INPP5J

1.77e-048512GO:0052658
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

PTPN13 IRS2 FAM83A

1.80e-0443513GO:0043548
GeneOntologyMolecularFunctioninositol tetrakisphosphate phosphatase activity

INPP5K INPP5J

2.28e-049512GO:0052743
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate binding

SH3PXD2B SH3PXD2A OBSCN

2.50e-0448513GO:0032266
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate binding

VIL1 SH3PXD2B SH3PXD2A OBSCN

2.57e-04121514GO:1902936
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

INPP5K INPP5J

2.84e-0410512GO:0004439
GeneOntologyMolecularFunctionsuperoxide-generating NADPH oxidase activator activity

SH3PXD2B SH3PXD2A

2.84e-0410512GO:0016176
GeneOntologyMolecularFunctionphosphatidylinositol trisphosphate phosphatase activity

INPP5K INPP5J

3.47e-0411512GO:0034594
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate phosphatase activity

INPP5K INPP5J

4.15e-0412512GO:0106019
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 5-phosphatase activity

INPP5K INPP5J

4.90e-0413512GO:0034595
GeneOntologyMolecularFunctionhistone binding

PHF2 MSH6 PSME4 HJURP ZZEF1

5.66e-04265515GO:0042393
GeneOntologyMolecularFunctioninositol trisphosphate phosphatase activity

INPP5K INPP5J

5.71e-0414512GO:0046030
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulatory subunit binding

PTPN13 FAM83A

5.71e-0414512GO:0036312
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH6 DNAH7

9.53e-0418512GO:0008569
GeneOntologyMolecularFunctioninositol phosphate phosphatase activity

INPP5K INPP5J

1.18e-0320512GO:0052745
GeneOntologyMolecularFunctionproteasome binding

PSME4 SACS

1.18e-0320512GO:0070628
GeneOntologyMolecularFunctionmethylated histone binding

PHF2 MSH6 ZZEF1

1.38e-0386513GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

PHF2 MSH6 ZZEF1

1.48e-0388513GO:0140034
GeneOntologyMolecularFunctionphosphatidylinositol phosphate binding

VIL1 SH3PXD2B SH3PXD2A OBSCN

1.66e-03199514GO:1901981
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate binding

VIL1 SH3PXD2A OBSCN

1.84e-0395513GO:0005546
GeneOntologyMolecularFunctionmodification-dependent protein binding

PHF2 MSH6 PSME4 ZZEF1

1.88e-03206514GO:0140030
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate phosphatase activity

INPP5K INPP5J

2.16e-0327512GO:0034593
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH6 DNAH7

2.32e-0328512GO:0051959
GeneOntologyMolecularFunctionphosphatidylinositol phosphate phosphatase activity

INPP5K INPP5J

2.66e-0330512GO:0052866
GeneOntologyMolecularFunctionlysine-acetylated histone binding

PSME4 ZZEF1

2.66e-0330512GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

PSME4 ZZEF1

2.84e-0331512GO:0140033
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate binding

SH3PXD2A OBSCN

3.61e-0335512GO:0043325
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH6 DNAH7

4.02e-0337512GO:0045505
GeneOntologyMolecularFunctionstructural constituent of muscle

OBSCN NEB

5.40e-0343512GO:0008307
GeneOntologyBiologicalProcesscytoplasmic actin-based contraction involved in cell motility

VIL1 LIMCH1

1.80e-053512GO:0060327
GeneOntologyCellularComponentinner dynein arm

DNAH6 DNAH7

2.49e-0410502GO:0036156
GeneOntologyCellularComponentactin cytoskeleton

VIL1 INTS6 FLT1 SH3PXD2B SH3PXD2A LIMCH1 NEB

4.16e-04576507GO:0015629
DomainIPPc

INPP5K INPP5J

2.99e-0410492IPR000300
DomainIPPc

INPP5K INPP5J

2.99e-0410492SM00128
Domain-

FRMD4A PTPN13 ARHGAP23 PLCL2 OBSCN IRS2

5.30e-043914962.30.29.30
DomainDynein_heavy_chain_D4_dom

DNAH6 DNAH7

6.01e-0414492IPR024317
DomainDynein_HC_stalk

DNAH6 DNAH7

6.01e-0414492IPR024743
DomainDynein_heavy_dom-2

DNAH6 DNAH7

6.01e-0414492IPR013602
DomainDHC_N2

DNAH6 DNAH7

6.01e-0414492PF08393
DomainMT

DNAH6 DNAH7

6.01e-0414492PF12777
DomainAAA_8

DNAH6 DNAH7

6.01e-0414492PF12780
DomainDHC_fam

DNAH6 DNAH7

6.93e-0415492IPR026983
DomainDynein_heavy_dom

DNAH6 DNAH7

6.93e-0415492IPR004273
DomainDynein_heavy

DNAH6 DNAH7

6.93e-0415492PF03028
DomainPH_dom-like

FRMD4A PTPN13 ARHGAP23 PLCL2 OBSCN IRS2

8.29e-04426496IPR011993
Domain-

INPP5K INPP5J

2.11e-03264923.60.10.10
DomainFERM_C

FRMD4A PTPN13

2.11e-0326492PF09380
DomainExo_endo_phos

INPP5K INPP5J

2.11e-0326492PF03372
DomainEndo/exonuclease/phosphatase

INPP5K INPP5J

2.27e-0327492IPR005135
DomainFERM_C

FRMD4A PTPN13

2.27e-0327492SM01196
DomainFERM_PH-like_C

FRMD4A PTPN13

2.27e-0327492IPR018980
DomainSH3

SH3PXD2B SH3PXD2A OBSCN NEB

2.45e-03216494SM00326
DomainSH3

SH3PXD2B SH3PXD2A OBSCN NEB

2.45e-03216494PS50002
DomainSH3_domain

SH3PXD2B SH3PXD2A OBSCN NEB

2.62e-03220494IPR001452
DomainFERM_N

FRMD4A PTPN13

3.38e-0333492PF09379
DomainFERM_N

FRMD4A PTPN13

3.38e-0333492IPR018979
DomainPX

SH3PXD2B SH3PXD2A

5.95e-0344492SM00312
DomainPH

ARHGAP23 PLCL2 OBSCN IRS2

6.02e-03278494SM00233
DomainPH_DOMAIN

ARHGAP23 PLCL2 OBSCN IRS2

6.09e-03279494PS50003
DomainPH_domain

ARHGAP23 PLCL2 OBSCN IRS2

6.17e-03280494IPR001849
DomainFERM_M

FRMD4A PTPN13

6.48e-0346492PF00373
DomainPX

SH3PXD2B SH3PXD2A

7.33e-0349492PF00787
Domain-

FRMD4A PTPN13

7.33e-03494921.20.80.10
DomainFERM_central

FRMD4A PTPN13

7.33e-0349492IPR019748
DomainFERM_domain

FRMD4A PTPN13

7.33e-0349492IPR000299
DomainFERM_1

FRMD4A PTPN13

7.62e-0350492PS00660
DomainFERM_2

FRMD4A PTPN13

7.62e-0350492PS00661
DomainFERM_3

FRMD4A PTPN13

7.62e-0350492PS50057
DomainPX

SH3PXD2B SH3PXD2A

7.62e-0350492PS50195
DomainBand_41_domain

FRMD4A PTPN13

7.62e-0350492IPR019749
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

VIL1 DENND4A SACS SH3PXD2A UBR4 EIF4G1 ZBTB21 EIF5B PADI6 PRPF6 LIMCH1 NEB SPEN DNAH6 RBFA

1.34e-091442511535575683
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SH3PXD2B DENND4A PTPN13 HIVEP2 SH3PXD2A HJURP EIF4G1 ZBTB21 IRS2 LIMCH1 DNAH7 ENKD1

3.21e-09861511236931259
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

PHF2 ATXN7L3 MSH6 INTS6 ARHGAP23 INPP5K UCKL1 ZBTB21 IRS2 ZZEF1 TCF7L1 ENKD1

5.62e-081116511231753913
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MSH6 EIF4G1 ZBTB21 EIF5B UBA2 MICAL3 IRS2 LIMCH1 COIL SPEN

1.58e-07774511015302935
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PHF2 MSH6 INTS6 PTPN13 SACS EIF4G1 EIF5B INTS4 PRPF6 COIL SPEN

3.83e-071082511138697112
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SH3PXD2B HIVEP2 PSME4 UCKL1 UBR4 EIF4G1 OBSCN MICAL3 IRS2 ZZEF1 SPEN

4.71e-071105511135748872
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

VIL1 MSH6 DENND4A INPP5K UBR4 DHX38 EIF4G1 ZBTB21 UBA2 IRS2 PRPF6

2.04e-061284511117353931
Pubmed

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.

SH3PXD2B SH3PXD2A

2.11e-06251227802184
Pubmed

A PiggyBac-based recessive screening method to identify pluripotency regulators.

MSH6 TCF7L1

2.11e-06251221533166
Pubmed

Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.

FRMD4A ARHGAP23 MICAL3 LIMCH1

2.94e-066751429254152
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MSH6 UBR4 DHX38 EIF4G1 EIF5B PRPF6 COIL SPEN

4.63e-0665351822586326
Pubmed

Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.

SH3PXD2B SH3PXD2A

6.32e-06351225259869
Pubmed

Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.

SH3PXD2B SH3PXD2A

6.32e-06351220609497
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

FLT1 OBSCN MICAL3 IRS2 PRPF6 LIMCH1 NEB

7.84e-0649751736774506
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

MSH6 SH3PXD2B SACS UBR4 DHX38 EIF5B PRPF6

7.95e-0649851736634849
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PHF2 INTS6 PTPN13 THEM4 HIVEP2 SH3PXD2A UCKL1 OBSCN MICAL3 LIMCH1 TATDN1

8.38e-061489511128611215
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

MSH6 UCKL1 EIF4G1 EIF5B IRS2 COIL SPEN

8.48e-0650351716964243
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PHF2 ATXN7L3 MSH6 INTS6 PTPN13 DHX38 EIF4G1 EIF5B LIMCH1 SPEN RBFA

8.81e-061497511131527615
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

DENND4A UBR4 EIF4G1 IRS2 SPEN DNAH6

1.46e-0536151626167880
Pubmed

Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation.

INPP5K INPP5J

2.10e-05551212536145
Pubmed

Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.

SH3PXD2B SH3PXD2A

2.10e-05551219755710
Pubmed

Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.

DNAH6 DNAH7

2.10e-05551239056782
Pubmed

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.

FLT1 PTPN13

3.15e-05651225893857
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

PHF2 MSH6 DENND4A UBR4 DHX38 EIF4G1 EIF5B PRPF6 COIL SPEN

3.56e-051425511030948266
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

MSH6 PSME4 UBR4 DHX38 EIF4G1 EIF5B UBA2 LIMCH1 ZZEF1 TATDN1

4.24e-051455511022863883
Pubmed

A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus.

VIL1 NEB

5.87e-0585121970800
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

PHF2 INTS6 MICAL3 PRPF6 SPEN

5.96e-0528351518854154
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

INTS6 ARHGAP23 UBR4 EIF5B LIMCH1 INPP5J

6.73e-0547551631040226
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

FRMD4A SH3PXD2B UBR4 MICAL3

7.66e-0515351410718198
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PHF2 ARHGAP23 SACS DHX38 EIF5B MICAL3

8.26e-0549351615368895
Pubmed

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.

PHF2 INTS6 SACS

9.11e-055951334108663
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MSH6 UBR4 DHX38 EIF4G1 ZBTB21 EIF5B UBA2 PRPF6

1.06e-04101451832416067
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

PTPN13 HIVEP2 PSME4 UBR4 NEB

1.09e-0432251526514267
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PHF2 MSH6 UBR4 DHX38 EIF4G1 EIF5B UBA2 PRPF6 COIL

1.14e-04131851930463901
Pubmed

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.

INTS6 INTS4

1.15e-041151223904267
Pubmed

The DNA sequence and analysis of human chromosome 13.

INTS6 SACS IRS2 CCDC168

1.15e-0417051415057823
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

MSH6 UBR4 EIF4G1 UBA2 PRPF6

1.26e-0433251532786267
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PHF2 MSH6 PTPN13 DHX38 PLCL2 INTS4 MICAL3 COIL

1.34e-04104951827880917
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

UBR4 DHX38 EIF5B PRPF6 SPEN

1.43e-0434151532971831
Pubmed

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.

MSH6 EIF4G1 EIF5B

1.58e-047151329346117
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

MSH6 INTS6 EIF4G1 UBA2 INTS4 PRPF6

1.65e-0456051635241646
Pubmed

Structure of the catalytic core of the Integrator complex.

INTS6 INTS4

1.90e-041451233548203
Pubmed

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.

INTS6 INTS4

1.90e-041451232697989
Pubmed

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.

INTS6 INTS4

1.90e-041451232647223
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH6 DNAH7

1.90e-04145129373155
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

MSH6 INTS6 EIF4G1 PRPF6 COIL

2.08e-0437051522922362
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

MSH6 UBR4 EIF4G1 EIF5B UBA2 MICAL3 PRPF6 LIMCH1

2.50e-04114951835446349
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

MSH6 DHX38 EIF4G1 PRPF6 COIL SPEN

2.50e-0460551628977666
Pubmed

Myosin-X recruits lamellipodin to filopodia tips.

SACS UBR4 COIL

3.09e-048951336861887
Pubmed

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.

EIF4G1 EIF5B MICAL3 PRPF6 COIL

3.09e-0440351535253629
Pubmed

SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study.

VIL1 UBR4

3.18e-041851236877072
Pubmed

The contribution of de novo coding mutations to autism spectrum disorder.

PHF2 SPEN

3.18e-041851225363768
Pubmed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.

OBSCN NEB

3.55e-041951227171814
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DENND4A PSME4 ARHGAP23 DHX38 MICAL3 ZZEF1

3.67e-0465051638777146
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

MSH6 PTPN13 DHX38 ZBTB21 EIF5B IRS2 COIL

4.07e-0493451733916271
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

MSH6 INPP5K DHX38 EIF4G1 EIF5B PRPF6 COIL SPEN

4.55e-04125751836526897
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

MSH6 INTS6 INTS4 PRPF6

4.56e-0424451429884807
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

SH3PXD2B SH3PXD2A IRS2

4.74e-0410351321706016
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

PHF2 ATXN7L3 INTS6 DHX38 INTS4 PRPF6 COIL SPEN

5.51e-04129451830804502
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

PHF2 FRMD4A SPEN

5.59e-0410951333554859
Pubmed

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.

INTS6 INTS4

6.19e-042551234004147
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

SH3PXD2B PTPN13 SH3PXD2A EIF4G1 EIF5B SPEN

6.47e-0472451636232890
Pubmed

Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.

INTS4 PRPF6

6.70e-042651233298525
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

SACS EIF4G1 ZBTB21 EIF5B PRPF6 COIL SPEN

7.03e-04102451724711643
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MSH6 PSME4 ARHGAP23 UBR4 DHX38 EIF4G1 EIF5B PRPF6

7.38e-04135351829467282
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

MSH6 DHX38 COIL SPEN

7.94e-0428351430585729
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

CD93 EIF4G1 CCDC168

7.94e-0412351326912792
Pubmed

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.

VIL1 MSH6 LIMCH1

8.32e-0412551321654808
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SH3PXD2B PTPN13 PSME4 DHX38 HJURP PLCL2 OBSCN

9.81e-04108451711544199
Pubmed

The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.

UBR4 UBA2

1.02e-033251236278411
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

PSME4 UBR4 OBSCN PRPF6

1.04e-0330451432235678
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PHF2 MSH6 ZBTB21 EIF5B UBA2 PRPF6 SPEN

1.08e-03110351734189442
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

PHF2 MSH6 PTPN13 DHX38 EIF5B

1.09e-0353351530554943
Pubmed

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.

UBR4 EIF4G1 IRS2

1.23e-0314351330397336
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

MSH6 SH3PXD2B PTPN13 COIL SPEN

1.24e-0354951538280479
Pubmed

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

MSH6 THEM4 SH3PXD2A UBR4

1.32e-0332551436168628
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

MSH6 OBSCN FAM83A

1.38e-0314951325184681
InteractionYWHAH interactions

FRMD4A SH3PXD2B DENND4A PTPN13 HIVEP2 SH3PXD2A DHX38 HJURP EIF4G1 ZBTB21 IRS2 PRPF6 LIMCH1 DNAH7 ENKD1

5.28e-0811025115int:YWHAH
InteractionSUPT5H interactions

PHF2 MSH6 INTS6 UBR4 DHX38 EIF5B INTS4 COIL SPEN

7.50e-07408519int:SUPT5H
InteractionYWHAQ interactions

DENND4A PTPN13 HIVEP2 ARHGAP23 SH3PXD2A HJURP EIF4G1 ZBTB21 IRS2 NEB DNAH7 ENKD1

1.70e-0511185112int:YWHAQ
InteractionSH3PXD2A interactions

SH3PXD2B DENND4A PTPN13 SH3PXD2A ZBTB21

1.78e-05128515int:SH3PXD2A
InteractionINPP5E interactions

DENND4A PTPN13 SH3PXD2A ZBTB21

2.20e-0565514int:INPP5E
InteractionYWHAG interactions

FRMD4A DENND4A PTPN13 HIVEP2 ARHGAP23 SH3PXD2A HJURP EIF4G1 ZBTB21 IRS2 DNAH7 ENKD1

5.02e-0512485112int:YWHAG
InteractionZBTB21 interactions

DENND4A PTPN13 SH3PXD2A ZBTB21 COIL

5.34e-05161515int:ZBTB21
InteractionSEM1 interactions

INTS6 PSME4 UBR4 INTS4 DNAH6

5.50e-05162515int:SEM1
InteractionMECP2 interactions

PHF2 MSH6 INTS6 PTPN13 ARHGAP23 SACS EIF4G1 EIF5B INTS4 PRPF6 COIL SPEN

6.76e-0512875112int:MECP2
InteractionS100A2 interactions

INTS6 DENND4A PTPN13 ZBTB21 MICAL3 ENKD1 RBFA

7.56e-05412517int:S100A2
InteractionGIGYF1 interactions

DENND4A PTPN13 SH3PXD2A ZBTB21 ENKD1

8.36e-05177515int:GIGYF1
InteractionHDAC4 interactions

INTS6 DENND4A ARHGAP23 SH3PXD2A UBR4 ZBTB21 EIF5B LIMCH1 INPP5J

9.18e-05744519int:HDAC4
InteractionCBY1 interactions

DENND4A PTPN13 SH3PXD2A ZBTB21 ENKD1

9.54e-05182515int:CBY1
InteractionDENND1A interactions

DENND4A PTPN13 SH3PXD2A ZBTB21

1.24e-04101514int:DENND1A
InteractionYWHAB interactions

DENND4A PTPN13 ARHGAP23 SH3PXD2A HJURP EIF4G1 ZBTB21 IRS2 PRPF6 NEB

1.93e-0410145110int:YWHAB
InteractionRTKN interactions

DENND4A PTPN13 SH3PXD2A ZBTB21

2.04e-04115514int:RTKN
Cytoband13q12

FLT1 SACS

3.29e-042451213q12
Cytoband8q24.13

TATDN1 FAM83A

7.44e-04365128q24.13
Cytoband1p36.13

UBR4 PADI6

1.79e-03565121p36.13
Cytoband2p11.2

DNAH6 TCF7L1

2.33e-03645122p11.2
GeneFamilyIntegrator complex

INTS6 INTS4

3.34e-04153321366
GeneFamilyDyneins, axonemal

DNAH6 DNAH7

4.32e-0417332536
GeneFamilyPhosphoinositide phosphatases

INPP5K INPP5J

1.55e-03323321079
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMD4A PTPN13

3.75e-03503321293
GeneFamilyLIM domain containing

MICAL3 LIMCH1

5.18e-03593321218
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

MSH6 PTPN13 HIVEP2 PSME4 SACS GLRB MICAL3 ZZEF1 SPEN

3.60e-05856519M4500
CoexpressionGSE360_CTRL_VS_B_MALAYI_HIGH_DOSE_DC_DN

PHF2 CD93 MICAL3 IRS2 ZZEF1

4.24e-05199515M5151
CoexpressionGSE17721_LPS_VS_POLYIC_1H_BMDC_DN

PHF2 SACS UCKL1 EIF5B SPEN

4.24e-05199515M3800
CoexpressionGSE557_WT_VS_CIITA_KO_DC_DN

MSH6 SH3PXD2A PLCL2 INTS4 COQ10B

4.35e-05200515M6008
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 ARHGAP23 LIMCH1 TCF7L1

3.13e-061985158a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

UBR4 CCDC168 SPEN TCF7L1

2.56e-05149514768877bade04ca0321593b8470b5011ad8270431
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN13 CCDC168 ENKD1 FAM83A

4.09e-05168514a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellIonocyte-iono-1|World / Class top

FRMD4A DENND4A PLCL2 LIMCH1

4.18e-051695144b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

VIL1 FRMD4A INTS6 THEM4

4.79e-051755146374ab186d7ccf7f6dfb858267edba8962789e15
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRMD4A PLCL2 OBSCN ENKD1

4.90e-0517651423fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRMD4A PLCL2 OBSCN ENKD1

4.90e-0517651430adf8f1638c6244586f8101c2590bb964dfae00
ToppCellCiliated_cells-B-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

UBA2 GARIN1B DNAH6 DNAH7

5.01e-05177514c38138fb5ad9766c2d240811210c854338cd612e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN13 PLCL2 LIMCH1 TCF7L1

5.35e-05180514023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCellRV|World / Chamber and Cluster_Paper

PLCL2 OBSCN MICAL3 LIMCH1

5.46e-05181514bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 SACS LIMCH1

5.46e-0518151492d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCelldroplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 SACS LIMCH1

5.58e-0518251481279877b920b5a1bc991a07d3031d6458700fe3
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 SACS LIMCH1

6.07e-051865140ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN13 PLCL2 LIMCH1 TCF7L1

6.33e-05188514e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

PLCL2 OBSCN MICAL3 LIMCH1

6.33e-051885140758b474457efa36488e0195f7357100f4b6a090
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN13 PLCL2 LIMCH1 TCF7L1

6.46e-05189514c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 ARHGAP23 LIMCH1

6.46e-05189514e60a3d6aa84788c29f23439f1c747431ea581bc3
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

PLCL2 OBSCN MICAL3 LIMCH1

6.46e-051895145e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN13 PLCL2 LIMCH1 TCF7L1

6.59e-0519051411d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

PLCL2 OBSCN MICAL3 LIMCH1

6.59e-05190514fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 ARHGAP23 TCF7L1

6.73e-0519151488f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 ARHGAP23 TCF7L1

6.73e-051915141924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

PLCL2 OBSCN MICAL3 LIMCH1

6.87e-05192514ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DENND4A HIVEP2 UBR4 ZBTB21

6.87e-051925146bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3PXD2A UBR4 EIF4G1 NEB

7.01e-05193514fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 ARHGAP23 LIMCH1

7.01e-05193514c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3PXD2A UBR4 EIF4G1 NEB

7.01e-05193514471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3PXD2A UBR4 EIF4G1 NEB

7.15e-051945143a3ecedcdc7691cf21775818b598208fcb980c29
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3PXD2A UBR4 EIF4G1 NEB

7.15e-051945140b023de48ed8a550d169bbe954881eb04bf4f981
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 LIMCH1 TCF7L1

7.44e-05196514ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 ARHGAP23 TCF7L1

7.44e-0519651481900dcc9451ff6606ec940c16b559d73247590e
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 ARHGAP23 TCF7L1

7.58e-05197514d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 ARHGAP23 TCF7L1

7.58e-05197514412091994196a06c2779b4c2cfed84be889a5f8d
ToppCellControl_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega|Control_saline / Treatment groups by lineage, cell group, cell type

DENND4A PSME4 PLCL2 FAM83A

7.73e-051985141a39a98beef68e1e6d3adc25270a3336fcc5baf4
ToppCellControl_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|Control_saline / Treatment groups by lineage, cell group, cell type

DENND4A PSME4 PLCL2 FAM83A

7.73e-05198514dd80fd9671ee863aebcf4c1023d3e004cc2ee709
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

MSH6 FLT1 DENND4A PLCL2

7.73e-05198514af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 LIMCH1 TCF7L1

7.73e-0519851407701c73137947ed4a27e225975329235bbb8734
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 LIMCH1 TCF7L1

7.73e-0519851431ba87552be97c9b78c9e82f98e96699ccb19824
ToppCell5'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 ARHGAP23 LIMCH1

7.73e-0519851490e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

MSH6 FLT1 DENND4A PLCL2

7.73e-0519851462cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 ARHGAP23 LIMCH1

7.73e-0519851458508a8df2714d769f137794c29441a7bd38b350
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 LIMCH1 TCF7L1

7.73e-05198514fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 LIMCH1 TCF7L1

7.73e-051985140a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCellControl_saline-Hematopoietic_Erythro-Megakary|Control_saline / Treatment groups by lineage, cell group, cell type

DENND4A PSME4 PLCL2 FAM83A

7.73e-05198514cfc2a860bae883299987d3e374d0476ca20e1bdd
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

MSH6 FLT1 DENND4A PLCL2

7.73e-05198514ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPN13 ARHGAP23 OBSCN TCF7L1

7.73e-051985145374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 ARHGAP23 LIMCH1

7.89e-0519951407bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPN13 ARHGAP23 OBSCN TCF7L1

7.89e-0519951494a7867e800df352731796de8c24cba133c29622
ToppCellCOVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil|COVID-19_Mild / Disease, condition lineage and cell class

C12orf50 HJURP CCDC168 TCF7L1

7.89e-05199514e222b90caf45904d8f763574e7b6aac13333df92
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 ARHGAP23 LIMCH1

8.04e-05200514cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCellLPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DENND4A HJURP PLCL2 FAM83A

8.04e-05200514f100edfd2b3b742458cbbf34de9c403c4d272d3c
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 ARHGAP23 LIMCH1

8.04e-052005142554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 ARHGAP23 LIMCH1

8.04e-05200514b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF2 NEB TATDN1

3.42e-04119513c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCellControl-Endothelial-Endothelial-Activated_Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD93 FLT1 ARHGAP23

3.60e-04121513a5962d1c476e6966870832b72d511607e047248b
ToppCellASK440-Endothelial-Endothelium|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

CD93 FLT1 SPEN

3.68e-041225132f76ec3b527e9528fbb006599a96e8bbdf9e0e62
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

OBSCN MICAL3 LIMCH1

3.68e-041225131cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 DNAH6

3.96e-0412551335042ed43045dddc341b76cc5f9fe31b5ba0abb8
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

C12orf50 HJURP TCF7L1

4.05e-041265136cb89754010d64875e115da6c5805efac7a4a82d
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

C12orf50 HJURP TCF7L1

4.05e-0412651369b2525b92d1c7c35b21cc701f5fa52a9c1b94bb
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CCDC168 INPP5J FAM83A

4.05e-0412651384dce108561d4b745d19250c2ac0667d9e4ea17d
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

VIL1 CD93 DNAH6

4.54e-04131513d5bc40cd585582856881081b7130dec3515b4ae0
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 DNAH6

4.54e-04131513419a0a83b38eaea890d065c3f252ef83c2d37b5b
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

UBR4 CCDC168 SPEN

4.95e-041355133351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SH3PXD2B SACS TCF7L1

5.50e-04140513276b3fa924176426efb31112ed4d355407f0b218
ToppCellMS-CD4-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

C12orf50 ARHGAP23 FAM83A

5.62e-04141513df257dd4dcc45c1ace57340798e150a6e932531d
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

VIL1 CD93 FLT1

5.97e-041445131c118b22c2ff3a526a5207d6c9d772636ee065fd
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

SH3PXD2B HIVEP2

6.11e-0432512ba89b22a5ce8ee9f3099b1fa84721724b94c7759
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

SH3PXD2B HIVEP2

6.11e-043251258b212d4f2955f06a195df0f79ad95a8ff145b83
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

VIL1 CD93 FLT1

6.60e-04149513d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCellfacs-Limb_Muscle-Muscle_Diaphragm-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 DNAH6

6.73e-0415051396b160f163030fbf48aedc37d6ae224e11492c52
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

VIL1 CD93 FLT1

7.26e-04154513b0735365de153d4586ca17896431d7bd9c7d8eac
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CD93 FLT1 SH3PXD2A

7.54e-041565136c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A ARHGAP23 SACS

7.54e-04156513abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A ARHGAP23 SACS

7.54e-04156513dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

DENND4A HIVEP2 PSME4

7.54e-041565131545169694f686d28648a68b552c2ae606599d66
ToppCell10x5'-bone_marrow-Lymphocytic_B-GC_B_(I)|bone_marrow / Manually curated celltypes from each tissue

HJURP CCDC168 ENKD1

7.68e-04157513d4da4057917dda066da0f2aac2621fdaf1fb943b
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PHF2 EIF4G1 CCDC168

8.11e-0416051319105debef96ea0c267d6a1d332303ec668ae47e
ToppCell3'_v3-bone_marrow-Lymphocytic_B-Pre-B|bone_marrow / Manually curated celltypes from each tissue

FLT1 ARHGAP23 ENKD1

8.41e-04162513e088e66aabc307dde5d2b9aa295c34ef68155b1a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN13 PLCL2 LIMCH1

8.41e-04162513285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 ARHGAP23

8.56e-0416351373c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A PADI6 TCF7L1

8.71e-04164513f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

VIL1 CD93 FLT1

8.86e-041655137d319a112b9062efee428bef6f4534d2ce782e04
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH6 DNAH7 INPP5J

8.86e-04165513731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 ZBTB21 COIL

9.02e-04166513c11dcf9705b85ac3da6ae86358f5ffd64ae8327e
ToppCelldroplet-Heart-nan-18m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSH6 PTPN13 HJURP

9.02e-041665139adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

FLT1 ARHGAP23 OBSCN

9.18e-041675135af9127bae05768a5164d5708a4ad37edca99324
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OBSCN LIMCH1 FAM83A

9.34e-04168513d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HJURP PLCL2 ZBTB21

9.34e-041685134c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCell343B-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

VIL1 SH3PXD2A LIMCH1

9.50e-04169513e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

PTPN13 SPEN FAM83A

9.83e-04171513adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCellP15|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 FLT1 HIVEP2

9.83e-04171513155e7abd52b84d16146001f6ca49ca0c2294a823
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-non-classical_monocyte|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CD93 SH3PXD2B LIMCH1

9.99e-04172513968d18ab8c3cdeb7936a2aa721a7f41525763863
ToppCellE12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 FLT1 LIMCH1

9.99e-04172513ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCelldroplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 FLT1 ARHGAP23

9.99e-04172513a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCellE12.5-Endothelial-proliferative_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 FLT1 LIMCH1

9.99e-041725132136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GARIN1B DNAH6 DNAH7

1.02e-03173513c3762655caa79ac4879876f470d32578a3c93b01
ToppCelldroplet-Fat-Scat-21m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 LIMCH1 NEB

1.02e-03173513f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 FLT1 LIMCH1

1.02e-03173513b57d14e2c2368304cb903562d06ce8228f53857c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD93 FLT1 ARHGAP23

1.02e-031735133877cead288ce9509e6cccf57e55ec5e1bd7ce18
Diseasethyroid gland carcinoma (is_marker_for)

CD93 FLT1

1.76e-0412492DOID:3963 (is_marker_for)
Diseaseintellectual disability (implicated_via_orthology)

HIVEP2 UBR4 IRS2

2.67e-0475493DOID:1059 (implicated_via_orthology)
DiseaseFEV/FEC ratio

PHF2 FRMD4A FLT1 HIVEP2 SH3PXD2A MICAL3 NEB TCF7L1

8.68e-041228498EFO_0004713
Diseasechronic obstructive pulmonary disease

FRMD4A FLT1 HIVEP2 SH3PXD2A MICAL3 TCF7L1

9.37e-04688496EFO_0000341
DiseaseThyroid Gland Follicular Adenoma

MSH6 TCF7L1

1.55e-0335492C0151468
DiseaseThyroid Neoplasm

MSH6 TCF7L1

1.73e-0337492C0040136
Diseaseadiponectin measurement

FRMD4A HIVEP2 MICAL3

1.85e-03146493EFO_0004502
DiseaseMalignant neoplasm of breast

MSH6 FLT1 INPP5K UBR4 OBSCN SPEN TCF7L1

1.88e-031074497C0006142
Diseasenasopharynx carcinoma (is_marker_for)

FLT1 SPEN

2.34e-0343492DOID:9261 (is_marker_for)
DiseaseThyroid carcinoma

MSH6 TCF7L1

2.44e-0344492C0549473
Diseasereading and spelling ability

FRMD4A PTPN13 NEB

2.66e-03166493EFO_0005301
Diseasehair morphology measurement

FRMD4A THEM4

3.66e-0354492EFO_0007821

Protein segments in the cluster

PeptideGeneStartEntry
KALWRSPKYDKVESR

ENKD1

131

Q9H0I2
PWCKKSDVISKRSGY

COQ10B

106

Q9H8M1
KKEKKPQNAADSYSW

CD93

616

Q9NPY3
DNDWSYGSEKKAKKR

ATXN7L3

141

Q14CW9
DPSWKERKVTPSKYS

HJURP

371

Q8NCD3
KSYTKSEEKPRDRLW

DENND4A

1266

Q7Z401
KTKKKVWYESPSLGS

RBFA

51

Q8N0V3
KNLTKYPTDRDSIWK

INTS4

491

Q96HW7
KAKPTLKWRQSFESY

INTS6

401

Q9UL03
HTSKEESKKARVYWP

PADI6

211

Q6TGC4
PKSLWKSVFSGYKKD

MICAL3

1736

Q7RTP6
ETEPDCKYSKKHWKS

COIL

121

P38432
WVEEAYSKEKSSKKG

GLRB

16

P48167
WASAEKPYLKEKSSA

FAM83A

121

Q86UY5
LKSTKKGCKRYWTKT

MSH6

996

P52701
WRKSKKTVKVTRSYP

GARIN1B

11

Q96KD3
VTWYKDGKKLSSSSK

OBSCN

921

Q5VST9
TWYKDGKKLSSSSKV

OBSCN

1106

Q5VST9
WYKDGKKLSSSSKVR

OBSCN

1291

Q5VST9
VTWYKDGKKLSSSSK

OBSCN

1381

Q5VST9
TWYKDGKKLSSSSKV

OBSCN

1566

Q5VST9
YESEKKWRSKAGAPK

IRS2

76

Q9Y4H2
YDKSPIKPKMWSESS

FRMD4A

601

Q9P2Q2
LPSKRSKDYWIAKGS

DNAH6

4136

Q9C0G6
YDTSEKKRKPAWTDR

INPP5K

256

Q9BT40
PRVETKLYSKWESKS

DNAH7

441

Q8WXX0
KLYSKWESKSKPTTL

DNAH7

446

Q8WXX0
EKAWKPSSKRTAADK

EIF4G1

731

Q04637
KTADWKTRADPKTFA

CCDC168

2741

Q8NDH2
VLPREYKTKSCTKWK

SACS

3221

Q9NZJ4
KKKAEREEYRKSWST

LIMCH1

286

Q9UPQ0
KASWEEKPREMSKSY

PTPN13

956

Q12923
KYIRTAFPTKKKWES

TATDN1

236

Q6P1N9
KSKSEAKWKYKNSKP

PHF2

596

O75151
PSKKSVWLRAAYFEK

PRPF6

571

O94906
NKIDRLYDWKKSPDS

EIF5B

756

O60841
SLRWEPSKKDSEKAK

PLCL2

171

Q9UPR0
KRISTKEWAKSTGYD

UBA2

236

Q9UBT2
SAWRKRIPFSKTYSK

C12orf50

386

Q8NA57
KYDTSAKKRKPAWTD

INPP5J

666

Q15735
PFKWSNTKSYEDLKA

VIL1

716

P09327
KSWPKDSSVVYAKSL

ZBTB21

206

Q9ULJ3
PSWYMKKKKIRTDSE

SPEN

1491

Q96T58
PTWSARDNYGKKKKR

TCF7L1

411

Q9HCS4
KKCEDGSWKRLPSYK

THEM4

66

Q5T1C6
PKEDYGSSKRKSVWL

SH3PXD2A

131

Q5TCZ1
WAPATFIDKYKKTSN

SH3PXD2B

416

A1X283
AKSKGSWAPKKEPYA

ARHGAP23

1146

Q9P227
KKKSKVSSYKDWEES

DHX38

71

Q92620
YDSKTIPRTKKEWES

PSME4

1251

Q14997
RKTRYDTKVGTDKWP

ZZEF1

1146

O43149
PIYDFTTHSRKKDWK

UCKL1

181

Q9NWZ5
KRFTWTDSKPKASLK

FLT1

1256

P17948
CRKPYKKWEDSETPK

HIVEP2

641

P31629
KRDPKASYDAWKKCL

UBR4

4061

Q5T4S7
YKKDFEKWKTKFSSP

NEB

2346

P20929
YKKEFEKWKTKFSSP

NEB

3561

P20929
DDIKYRKDWNATKSK

NEB

4176

P20929