Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CXorf40	EOLA2 EOLA1	1.77e-05	2	79	2	IPR033615
Domain	ASCH_domain	EOLA2 EOLA1	5.29e-05	3	79	2	IPR007374
Domain	ASCH	EOLA2 EOLA1	5.29e-05	3	79	2	SM01022
Domain	DNA/RNA_helicase_DEAH_CS	DHX57 CHD3 DHX8	4.32e-04	35	79	3	IPR002464
Domain	Sec1	SCFD2 VPS33A	4.87e-04	8	79	2	PF00995
Domain	Sec1-like	SCFD2 VPS33A	4.87e-04	8	79	2	IPR001619
Domain	-	SCFD2 VPS33A	4.87e-04	8	79	2	3.40.50.1910
Domain	Sec-1-like_dom2	SCFD2 VPS33A	4.87e-04	8	79	2	IPR027482
Domain	DEAH_ATP_HELICASE	DHX57 CHD3 DHX8	5.52e-04	38	79	3	PS00690
Domain	Plexin_cytopl	PLXNA4 PLXNA2	6.24e-04	9	79	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA4 PLXNA2	6.24e-04	9	79	2	IPR013548
Domain	Plexin	PLXNA4 PLXNA2	6.24e-04	9	79	2	IPR031148
Domain	Rap_GAP	GARNL3 SIPA1L1	7.78e-04	10	79	2	PF02145
Domain	Rap_GAP_dom	GARNL3 SIPA1L1	9.48e-04	11	79	2	IPR000331
Domain	RAPGAP	GARNL3 SIPA1L1	9.48e-04	11	79	2	PS50085
Domain	-	PTPRC PDGFRA KALRN UNC5B SIGLEC10 PLXNA4 IL20RA TREML1 PLXNA2	1.90e-03	663	79	9	2.60.40.10
Domain	DUF1605	DHX57 DHX8	2.31e-03	17	79	2	IPR011709
Domain	OB_NTP_bind	DHX57 DHX8	2.31e-03	17	79	2	PF07717
Domain	HA2	DHX57 DHX8	2.59e-03	18	79	2	SM00847
Domain	HA2	DHX57 DHX8	2.59e-03	18	79	2	PF04408
Domain	Helicase-assoc_dom	DHX57 DHX8	2.59e-03	18	79	2	IPR007502
Domain	PUA-like_domain	EOLA2 EOLA1	2.88e-03	19	79	2	IPR015947
Domain	Ig-like_fold	PTPRC PDGFRA KALRN UNC5B SIGLEC10 PLXNA4 IL20RA TREML1 PLXNA2	2.91e-03	706	79	9	IPR013783
Domain	-	CLPP ACACA	3.52e-03	21	79	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	CLPP ACACA	3.52e-03	21	79	2	IPR029045
Domain	IPT	PLXNA4 PLXNA2	5.79e-03	27	79	2	SM00429
Domain	TIG	PLXNA4 PLXNA2	7.59e-03	31	79	2	PF01833
Domain	Sema	PLXNA4 PLXNA2	7.59e-03	31	79	2	SM00630
Domain	Semap_dom	PLXNA4 PLXNA2	7.59e-03	31	79	2	IPR001627
Domain	Sema	PLXNA4 PLXNA2	7.59e-03	31	79	2	PF01403
Domain	SEMA	PLXNA4 PLXNA2	7.59e-03	31	79	2	PS51004
Domain	PSI	PLXNA4 PLXNA2	8.07e-03	32	79	2	PF01437
Domain	IPT	PLXNA4 PLXNA2	8.07e-03	32	79	2	IPR002909
Domain	Plexin_repeat	PLXNA4 PLXNA2	8.07e-03	32	79	2	IPR002165
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	UBE2O ACACA COPB1 AHNAK NUP210 UTP14A HNRNPA3 PSMD1 DHX57 UPF1 DHX8	3.47e-07	653	81	11	22586326
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	KIFBP COPB1 AHNAK VPS33A HNRNPA3 PSMD1 CHD3 UPF1 TTK DHX8	1.03e-06	582	81	10	20467437
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PDE2A UBE2O COPB1 KALRN SIPA1L1 KTN1 HNRNPA3 PLXNA4 DHX57 CHD3 UPF1 CORO7 MADD PNMA8B	5.16e-06	1431	81	14	37142655
Pubmed	The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin.	UBR2 UBE2O	5.36e-06	2	81	2	31268597
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	UNC5B PLXNA4 CDH6 PLXNA2 CUX1	1.18e-05	126	81	5	16284245
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	UBE2O SENP6 PHF14 CHD3 JMJD1C CUX1 PRDM2 NSMCE1 DHX8	1.23e-05	608	81	9	36089195
Pubmed	SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability.	PDGFRA PLXNA4 PLXNA2	1.57e-05	21	81	3	38062045
Pubmed	Structural Basis for Plexin Activation and Regulation.	PLXNA4 PLXNA2	1.60e-05	3	81	2	27397516
Pubmed	Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers.	PLXNA4 PLXNA2	1.60e-05	3	81	2	17296555
Pubmed	Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.	PLXNA4 PLXNA2	1.60e-05	3	81	2	18625214
Pubmed	Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.	PLXNA4 PLXNA2	1.60e-05	3	81	2	22777942
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SCFD2 KIFBP CLTCL1 COPB1 AHNAK SIPA1L1 KTN1 NUP210 HNRNPA3 PSMD1 DHX57 UPF1 CUX1	2.71e-05	1440	81	13	30833792
Pubmed	Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.	PLXNA4 CDH6 PLXNA2	3.04e-05	26	81	3	39152101
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	UBR2 OXA1L ACACA COPB1 SIPA1L1 KTN1 UTP14A HNRNPA3 PSMD1 UPF1 CUX1 DHX8	3.09e-05	1247	81	12	27684187
Pubmed	Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.	PLXNA4 PLXNA2	3.20e-05	4	81	2	11306810
Pubmed	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	PLXNA4 PLXNA2	3.20e-05	4	81	2	25518740
Pubmed	130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus.	EOLA2 EOLA1	3.20e-05	4	81	2	8717057
Pubmed	The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.	CLPP PDE2A VPS33A DHX8	3.59e-05	79	81	4	25921334
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CLPP SCFD2 KIFBP UBE2O SLC4A7 OXA1L UNC5B KTN1 NUP210 UTP14A UPF1 TTK CUX1	3.78e-05	1487	81	13	33957083
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	CLPP SCFD2 KIFBP SLC4A7 OXA1L KTN1 UTP14A HNRNPA3 PSMD1 DHX57 UPF1 TTK CUX1	4.02e-05	1496	81	13	32877691
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	HDAC6 COPB1 UNC5B AHNAK KTN1 PSMD1 UPF1 TTK JMJD1C	4.03e-05	708	81	9	39231216
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PPP4R1 PDE2A UBE2O HDAC6 COPB1 KALRN IFT172 SIPA1L1 SENP6 PSMD1 CUX1 MADD	4.13e-05	1285	81	12	35914814
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	SLC4A7 ACACA COPB1 AHNAK SIPA1L1 KTN1 PSMD1	4.16e-05	399	81	7	37536630
Pubmed	Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina.	PLXNA4 PLXNA2	5.33e-05	5	81	2	22593055
Pubmed	Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.	ZNF33A ZNF33B	5.33e-05	5	81	2	8464732
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ACACA AHNAK PSMD1 CHD3 JMJD1C CUX1 PRDM2	5.58e-05	418	81	7	34709266
Pubmed	Identification of Redox and Glucose-Dependent Txnip Protein Interactions.	UBE2O AHNAK JMJD1C	5.75e-05	32	81	3	27437069
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	KIFBP UBE2O HDAC6 VPS33A UTP14A HNRNPA3 PSMD1 DHX57 CHD3 UPF1 TTK NSMCE1	5.96e-05	1335	81	12	29229926
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	AHNAK KTN1 UTP14A HNRNPA3 SENP6 PHF14 CHD3 JMJD1C CUX1 NSMCE1	7.43e-05	954	81	10	36373674
Pubmed	The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence.	PDGFRA CDH6 CUX1	7.55e-05	35	81	3	20943929
Pubmed	Diversification of stem cell molecular repertoire by alternative splicing.	KTN1 NUP210 TTK	7.55e-05	35	81	3	16183747
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PTPRC HDAC6 ACACA SIPA1L1 SENP6 PSMD1 PHF14 CHD3 PRDM2	7.99e-05	774	81	9	15302935
Pubmed	Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.	PLXNA4 PLXNA2	7.99e-05	6	81	2	28438183
Pubmed	Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers.	PLXNA4 PLXNA2	7.99e-05	6	81	2	20484647
Pubmed	Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord.	PDGFRA UNC5B	7.99e-05	6	81	2	12736344
Pubmed	Expression of connexin 43 protein in cardiomyocytes of heart failure mouse model.	PTPRC PDGFRA	7.99e-05	6	81	2	36277751
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	UBE2O SLC4A7 OXA1L HDAC6 ACACA AHNAK KTN1 UTP14A HNRNPA3 PSMD1 UPF1 DHX8	1.03e-04	1415	81	12	28515276
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CLTCL1 ACACA COPB1 AHNAK KTN1 VPS33A HNRNPA3 PSMD1 UPF1	1.10e-04	807	81	9	30575818
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KIFBP UBE2O ACACA COPB1 KTN1 NUP210 UTP14A HNRNPA3 PSMD1 UPF1 PRDM2 DHX8	1.11e-04	1425	81	12	30948266
Pubmed	Molecular and phenotypic variation in patients with severe Hunter syndrome.	EOLA2 EOLA1	1.12e-04	7	81	2	9147653
Pubmed	Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.	PLXNA4 PLXNA2	1.12e-04	7	81	2	19063725
Pubmed	Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.	PLXNA4 PLXNA2	1.12e-04	7	81	2	19655386
Pubmed	FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.	UNC5B CUX1	1.12e-04	7	81	2	25374360
Pubmed	FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development.	PLXNA4 CUX1	1.12e-04	7	81	2	27791111
Pubmed	Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.	CLTCL1 AHNAK HNRNPA3	1.22e-04	41	81	3	19805454
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	UBE2O ACACA COPB1 IFT172 NUP210 HNRNPA3 PSMD1 UPF1	1.22e-04	638	81	8	33239621
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	KALRN IFT172 SIPA1L1 DHX57 UPF1 ITIH3 MADD	1.23e-04	475	81	7	31040226
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CLTCL1 AHNAK KTN1 UTP14A HNRNPA3 PLXNA4 PSMD1 DHX57 PHF14 CHD3 PLXNA2 CUX1	1.24e-04	1442	81	12	35575683
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	UBE2O ACACA AHNAK NUP210 HNRNPA3 CUX1 DHX8	1.27e-04	477	81	7	31300519
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CLPP SLC38A10 SLC4A7 OXA1L PTPRC HDAC6 ACACA COPB1 PDGFRA AHNAK HNRNPA3 PSMD1	1.31e-04	1451	81	12	30550785
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PPP4R1 ACE2 UTP14A DHX57 CHD3 MIB2 JMJD1C MADD	1.38e-04	650	81	8	38777146
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNA4 PLXNA2	1.49e-04	8	81	2	15661641
Pubmed	Integration of opposing semaphorin guidance cues in cortical axons.	PLXNA4 PLXNA2	1.49e-04	8	81	2	22368082
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	UBR2 ZNF33A ZNF33B ACACA MORN1 NUP210 HNRNPA3 PSMD1 PHF14 CHD3 JMJD1C CUX1	1.67e-04	1489	81	12	28611215
Pubmed	PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination.	PLXNA4 CUX1	1.91e-04	9	81	2	33503438
Pubmed	Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina.	PLXNA4 PLXNA2	1.91e-04	9	81	2	38014224
Pubmed	The role of neuropilins in cell signalling.	PLXNA4 PLXNA2	1.91e-04	9	81	2	19909241
Pubmed	Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis.	HDAC6 REV1	1.91e-04	9	81	2	21690293
Pubmed	Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.	PDGFRA KTN1 DHX57 DTX3L UPF1	1.98e-04	228	81	5	30471916
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SLC4A7 PTPRC HDAC6 SIPA1L1 UTP14A PSMD1 CHD3 PRDM2 MADD LRRC71	2.10e-04	1084	81	10	11544199
Pubmed	Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.	PLXNA4 PLXNA2	2.38e-04	10	81	2	18804103
Pubmed	Kif14 mutation causes severe brain malformation and hypomyelination.	PDGFRA CUX1	2.38e-04	10	81	2	23308235
Pubmed	Intercellular genetic tracing of cardiac endothelium in the developing heart.	PTPRC PDGFRA	2.38e-04	10	81	2	37348503
Pubmed	Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos.	PTPRC PDGFRA	2.38e-04	10	81	2	19135046
Pubmed	TurboID-mediated proximity labeling technologies to identify virus co-receptors.	ACE2 ACACA	2.38e-04	10	81	2	38994005
Pubmed	B-1a lymphocytes promote oligodendrogenesis during brain development.	PTPRC PDGFRA	2.38e-04	10	81	2	29507409
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PDE2A SLC38A10 CLTCL1 ACACA MORN1 KALRN AHNAK MIB2 GBA2 MADD	2.45e-04	1105	81	10	35748872
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	UNC5B PLXNA4 PLXNA2	2.48e-04	52	81	3	26633812
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	PPP4R1 SLC4A7 ACACA PDGFRA ITFG2 UTP14A PHF14 UPF1 TTK CDH6 NSMCE1	2.51e-04	1327	81	11	32694731
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	UBE2O ACACA AHNAK TTK JMJD1C	2.61e-04	242	81	5	34011540
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	COPB1 UTP14A HNRNPA3 PSMD1 CHD3 UPF1 MADD DHX8	2.61e-04	714	81	8	28302793
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	UBE2O COPB1 AHNAK KTN1 PSMD1 CHD3 MADD	2.64e-04	538	81	7	28524877
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	KTN1 HNRNPA3 PSMD1 DHX57 CHD3 UPF1	2.82e-04	384	81	6	31059266
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ACACA AHNAK KTN1 UTP14A DHX57 UPF1 TTK DHX8	2.87e-04	724	81	8	36232890
Pubmed	Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries.	PDGFRA PLXNA2	2.91e-04	11	81	2	28714851
Pubmed	Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-α.	PDGFRA PHF14	2.91e-04	11	81	2	22730381
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HDAC6 ACACA COPB1 AHNAK KTN1 UTP14A HNRNPA3 PSMD1 DHX57 UPF1 CORO7	2.96e-04	1353	81	11	29467282
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	UBE2O ACACA AHNAK KTN1 UPF1 JMJD1C CUX1	2.98e-04	549	81	7	38280479
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	PPP4R1 SLC4A7 CLTCL1 HDAC6 AHNAK KTN1 MIB2 TTK MADD	3.02e-04	925	81	9	28986522
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	NUP210 UTP14A DHX57 CHD3 DHX8	3.03e-04	250	81	5	33536335
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	UBE2O SLC4A7 ACACA KALRN SIPA1L1 KTN1 VPS33A PSMD1 MIB2 MADD	3.12e-04	1139	81	10	36417873
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	COPB1 AHNAK HNRNPA3 PHF14 CHD3 CUX1	3.23e-04	394	81	6	27248496
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	UBE2O ACACA COPB1 AHNAK KTN1 UTP14A SENP6 CHD3 UPF1	3.24e-04	934	81	9	33916271
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	SLC4A7 COPB1 AHNAK CHD3 JMJD1C	3.38e-04	256	81	5	33397691
Pubmed	Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.	PLXNA4 PLXNA2	3.48e-04	12	81	2	25839327
Pubmed	PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.	PLXNA4 PLXNA2	3.48e-04	12	81	2	31690636
Pubmed	On and off retinal circuit assembly by divergent molecular mechanisms.	PLXNA4 PLXNA2	3.48e-04	12	81	2	24179230
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	PLXNA4 PLXNA2	3.48e-04	12	81	2	23991118
Pubmed	Mouse rump-white mutation associated with an inversion of chromosome 5.	PDGFRA VPS33A	3.48e-04	12	81	2	8043948
Pubmed	Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.	PLXNA4 PLXNA2	3.48e-04	12	81	2	28407732
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNA4 PLXNA2	3.48e-04	12	81	2	21270798
Pubmed	AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.	ACACA CUX1	3.48e-04	12	81	2	21436046
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	SCFD2 SLC4A7 AHNAK KTN1 GBA2 TTK CUX1	3.66e-04	568	81	7	37774976
Pubmed	Defining the membrane proteome of NK cells.	CLTCL1 PTPRC COPB1 PDGFRA AHNAK KTN1 NUP210 PSMD1 CORO7 TTK	3.80e-04	1168	81	10	19946888
Pubmed	Functional assembly of accessory optic system circuitry critical for compensatory eye movements.	PLXNA4 PLXNA2	4.11e-04	13	81	2	25959730
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNA4 PLXNA2	4.11e-04	13	81	2	10520995
Pubmed	Plexin signaling via off-track and rho family GTPases.	PLXNA4 PLXNA2	4.11e-04	13	81	2	11604131
Pubmed	Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase.	HDAC6 NSMCE1	4.11e-04	13	81	2	29225034
Pubmed	Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.	PTPRC CUX1	4.11e-04	13	81	2	28402856
Pubmed	Mouse placenta fetal macrophages arise from endothelial cells outside the placenta.	PTPRC PCDH12	4.11e-04	13	81	2	36473461
GeneFamily	Plexins	PLXNA4 PLXNA2	3.00e-04	9	53	2	683
GeneFamily	DEAH-box helicases	DHX57 DHX8	9.85e-04	16	53	2	500
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	UBR2 PTPRC AHNAK HNRNPA3 DTX3L JMJD1C PRDM2	8.85e-08	200	82	7	12f1685ce8f218433068e090c9d839cd5a1910bf
Drug	rosiglitazone; Up 200; 10uM; PC3; HT_HG-U133A	ACE2 MORN1 PDGFRA KALRN SENP6 IL20RA PLXNA2	3.78e-06	181	81	7	4457_UP
Drug	Tolazamide [1156-19-0]; Up 200; 12.8uM; PC3; HT_HG-U133A	PDE2A CLTCL1 PDGFRA UTP14A IL1RN CDH6 MADD	6.18e-06	195	81	7	4003_UP
Drug	Ethamivan [304-84-7]; Up 200; 18uM; MCF7; HT_HG-U133A	SLC4A7 HDAC6 SIPA1L1 IL20RA PCDH12 CDH6 PRDM2	6.61e-06	197	81	7	7021_UP
Disease	immature platelet count	PPP4R1 KALRN JMJD1C CUX1	1.92e-04	106	79	4	EFO_0803544
Disease	immature platelet fraction	PPP4R1 KALRN JMJD1C CUX1	2.54e-04	114	79	4	EFO_0009187
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	SIPA1L1 IL1RN TREML1 JMJD1C	4.31e-04	131	79	4	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	SIPA1L1 IL1RN TREML1 JMJD1C	4.31e-04	131	79	4	C4552091
Disease	Juvenile arthritis	SIPA1L1 IL1RN TREML1 JMJD1C	4.31e-04	131	79	4	C3495559
Disease	Juvenile psoriatic arthritis	SIPA1L1 IL1RN TREML1 JMJD1C	4.31e-04	131	79	4	C3714758
Disease	Juvenile-Onset Still Disease	SIPA1L1 IL1RN TREML1 JMJD1C	4.83e-04	135	79	4	C0087031
Disease	Malignant neoplasm of breast	PDE2A CATSPERE PTPRC KALRN SIPA1L1 KTN1 DTX3L KLHDC7A TREML1 CUX1	5.79e-04	1074	79	10	C0006142
Disease	C-X-C motif chemokine 11 measurement	JMJD1C CUX1	6.31e-04	14	79	2	EFO_0008057
Disease	polycystic kidney disease (implicated_via_orthology)	HDAC6 IFT172	6.31e-04	14	79	2	DOID:0080322 (implicated_via_orthology)
Disease	free cholesterol in large VLDL measurement	ANKRD31 JMJD1C ITIH3	8.17e-04	68	79	3	EFO_0022265
Disease	mitochondrial DNA measurement	UBE2O COPB1 IL1RN JMJD1C CUX1	1.89e-03	328	79	5	EFO_0006312

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALEVHVDPVGPLDKV	TMEM59L	216	Q9UK28
DVFQVDIPEHLIPLG	EOLA1	141	Q8TE69
DVFQVDIPEHLIPLG	EOLA2	141	Q96DE9
VHAIKPIVTGPDEEE	CATSPERE	76	Q5SY80
VIGDEHVVLPNFEPE	ADGB	771	Q8N7X0
DEDKVPRDEPIHILN	ACACA	1276	Q13085
RGPKVDIDAPDVDVH	AHNAK	2221	Q09666
KGVDPHEQDIRAEQP	RAB44	446	Q7Z6P3
HQPRFPKGEQELEIS	PCDH12	131	Q9NPG4
PEVLPHIEKELSEGR	ANKRD31	141	Q8N7Z5
VVAKRAGQPPHVLEE	MORN1	461	Q5T089
DPVPEEEDLGKRNRH	PDGFRA	1026	P16234
RVLDGPEKVPVVHVD	NUP210	1321	Q8TEM1
PILNLEKFHEGQEIP	MADD	441	Q8WXG6
FPRGPVDEKVIILVH	MAGEB10	106	Q96LZ2
EPRAKGVLLEPFVHQ	IP6K2	11	Q9UHH9
VLGEVNPLEEKPFHE	KIAA2026	406	Q5HYC2
KEQGLEVLPEHDPIR	JMJD1C	2411	Q15652
EGAAEHRLEKIPEPI	CUX1	461	Q13948
HPEEELENIVGVDIP	C2CD6	376	Q53TS8
VLGPEDLPVEVLQFH	CORO7	121	P57737
FPGIEDHPVLRELEV	PLXNA2	1326	O75051
FPGIEDHPVLRDLEV	PLXNA4	1326	Q9HCM2
DPPHELPQEGKVREA	PDE2A	96	O00408
PDAPELIHDFLVNEK	COPB1	171	P53618
EEIPPGILNKEHIIF	KALRN	1316	O60229
VVNPLLEPVEHRDGK	LRRC71	451	Q8N4P6
FPPHEELLKVISERE	KTN1	991	Q86UP2
QRVVHDLDKLPPREG	OXA1L	346	Q15070
FVPEEEKHEERVPRE	PHF14	836	O94880
IGEEQRPVFKQHIPA	ITFG2	111	Q969R8
GNLRPPQEEEEVKHL	IL20RA	346	Q9UHF4
LPAKQHVPEAEREEV	IFT172	1631	Q9UG01
KQRVVVVVRDHGDPP	PCDHAC1	631	Q9H158
HKIPFPQVEEAELDL	PLA2G4C	431	Q9UP65
EKPGVDEEPQHVLLR	UPF1	281	Q92900
GEHQILVDEKPVPIF	DTX3L	71	Q8TDB6
KRRNVIPHDIGDPDD	GBA2	586	Q9HCG7
GEEKPLDGQEHRERP	CHD3	1651	Q12873
FKHEVPPNQIVGRIE	DHX57	321	Q6P158
KREIVGVVEPVPHDE	ACE2	481	Q9BYF1
EEHFIQKAEGVEPRL	KLHDC7A	271	Q5VTJ3
GRPVEPESEFIIKIH	CDH6	136	P55285
NLEEKIDVVPIEPHA	IL1RN	66	P18510
PEGPERLHAIKEQLI	HDAC6	106	Q9UBN7
EEDKPRQVEVHQEPG	SLC38A10	741	Q9HBR0
EEKDHEVALIFPGPQ	DTWD1	131	Q8N5C7
DPNKVFPEHIGEDVL	KIFBP	526	Q96EK5
PHEIPKVFDPEKERE	NSMCE1	236	Q8WV22
EKGPREIFHPEIQKD	GARNL3	176	Q5VVW2
LVEEEPPFLRGHTKQ	DHX8	441	Q14562
AEVPEHVLRGLPEEV	PRDM2	16	Q13029
QKSDPEHPGRLVVEV	MIB2	426	Q96AX9
VVIHPPEEDLEAALK	SLC4A7	346	Q9Y6M7
PHIDDPDVKAQVEVL	PPP4R1	516	Q8TF05
DPHFIIQIPEKDDAL	ITIH3	651	Q06033
EDVNHAAIPREIPGK	PNMA8B	71	Q9ULN7
IEELVEPVAAHGPKI	PSMD1	921	Q99460
EPVAAHGPKIEEEEQ	PSMD1	926	Q99460
RGLPLKEVLEHVVPE	SIPA1L1	566	O43166
LKQVVEEIFHPERPD	SCFD2	576	Q8WU76
EEIVEVGAFPPEDIH	OXCT2	246	Q9BYC2
PFVVELEVLDGHDPE	ACOT4	101	Q8N9L9
KQEEHVTEPAPLVFD	CLTCL1	1621	P53675
LDKVLVHPPQDGEDE	CLPP	241	Q16740
FHFLPKVIPDVEDEG	TTLL8	81	A6PVC2
RVQVHPGEKPCELEE	ZNF778	271	Q96MU6
HKPEVIFRLEQGEEP	ZNF33B	56	Q06732
HLKPEEVDDFIRGQL	REV1	631	Q9UBZ9
GLVEDEHPKIEEPPI	UBE2O	746	Q9C0C9
KEVIPEHVAEFIEIP	ZNF654	651	Q8IZM8
KIQLDEPDHDPVEII	SENP6	471	Q9GZR1
LEKEEPAIAPIEHVL	UTP14A	161	Q9BVJ6
RGEEGHDPKEPEQLR	HNRNPA3	21	P51991
DQEPLGKEVPLDHEV	UNC5B	156	Q8IZJ1
HKPEVIFRLQQGEEP	ZNF33A	56	Q06730
EPHVEPAGERELEAK	UBL4B	141	Q8N7F7
NHEIEFPDIPEKDLQ	TTK	751	P33981
IEEVLRILPGPHFEE	VPS33A	511	Q96AX1
NILPPEEEEETHKIG	TREML1	121	Q86YW5
DPGVLELPRVQVEHE	SIGLEC10	406	Q96LC7
GLKVHPNEEDPRVPI	UBR2	1316	Q8IWV8
ILDVPPGVEKFQLHD	PTPRC	296	P08575
NHEEFEEIIRLPLKP	PNMA8C	36	A0A1B0GUJ8