Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

MET AATK PEAK1

1.08e-03145283GO:0004713
GeneOntologyMolecularFunctionzinc ion binding

TTF2 SLC39A4 RORB NR3C2 TRIP12 ZFAND2B

1.26e-03891286GO:0008270
GeneOntologyMolecularFunctionprotein kinase activity

AURKA MET AATK TEX14 PEAK1

1.33e-03600285GO:0004672
GeneOntologyMolecularFunctionstructural constituent of synapse

RAPSN BSN

1.58e-0342282GO:0098918
DomainPROTEIN_KINASE_TYR

MET AATK PEAK1

4.50e-0497293PS00109
DomainTyr_kinase_AS

MET AATK PEAK1

4.50e-0497293IPR008266
DomainHECT

ITCH TRIP12

7.98e-0427292PF00632
DomainHECTc

ITCH TRIP12

7.98e-0427292SM00119
DomainHECT_dom

ITCH TRIP12

7.98e-0427292IPR000569
DomainHECT

ITCH TRIP12

7.98e-0427292PS50237
DomainProt_kinase_dom

AURKA MET AATK TEX14 PEAK1

8.51e-04489295IPR000719
DomainPROTEIN_KINASE_DOM

AURKA MET AATK TEX14 PEAK1

8.83e-04493295PS50011
DomainPkinase_Tyr

MET AATK TEX14

1.03e-03129293PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

MET AATK TEX14

1.25e-03138293IPR001245
DomainKinase-like_dom

AURKA MET AATK TEX14 PEAK1

1.35e-03542295IPR011009
Domainzf-C4

RORB NR3C2

2.31e-0346292PF00105
DomainNUCLEAR_REC_DBD_1

RORB NR3C2

2.31e-0346292PS00031
DomainZnf_hrmn_rcpt

RORB NR3C2

2.31e-0346292IPR001628
DomainZnF_C4

RORB NR3C2

2.31e-0346292SM00399
DomainNUCLEAR_REC_DBD_2

RORB NR3C2

2.31e-0346292PS51030
DomainHOLI

RORB NR3C2

2.51e-0348292SM00430
DomainNucl_hrmn_rcpt_lig-bd

RORB NR3C2

2.51e-0348292IPR000536
DomainHormone_recep

RORB NR3C2

2.51e-0348292PF00104
DomainZnf_NHR/GATA

RORB NR3C2

3.65e-0358292IPR013088
DomainPROTEIN_KINASE_ATP

AURKA MET AATK PEAK1

5.25e-03459294PS00107
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

MET CRCT1 ITCH PEAK1 RASAL2 AGAP1

6.44e-0656929630639242
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

MET ITCH PEAK1 RASAL2 AGAP1

2.37e-0542129536976175
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

PEAK1 BSN AGAP1 TNRC6A

3.15e-0521829433378226
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

MET PEAK1 TRIP12 RASAL2 AGAP1 TNRC6A

3.73e-0577729635844135
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NR3C2 ITCH PEAK1 TRIP12 PHF3 RASAL2

6.60e-0586129636931259
Pubmed

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.

ITCH TEX14

1.83e-042429237100772
Pubmed

Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.

NR3C2 RAPSN TRIP12

2.03e-0413729330862715
Pubmed

The protein kinase complement of the human genome.

TEX14 PEAK1

2.50e-042829212471243
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

AATK TEX14 BSN TRIP12

4.28e-0443029435044719
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

AURKA TTF2 RASAL2 TNRC6A

4.92e-0444629424255178
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

AURKA TTF2 LARP4 PHF3

6.08e-0447229438943005
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

PEAK1 RASAL2 TNRC6A

6.97e-0420929336779422
GeneFamilyReceptor Tyrosine Kinases|CD molecules

MET AATK

1.17e-0340232321
GeneFamilyNuclear hormone receptors

RORB NR3C2

1.76e-034923271
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

AURKA AATK

2.20e-02181232694
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000

ITCH TEX14 PEAK1 LARP4 RASAL2 AGAP1 TNRC6A

5.21e-05778287gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

TTF2 ITCH TEX14 LARP4 RASAL2 AGAP1 TNRC6A

6.51e-05806287gudmap_developingGonad_e12.5_epididymis_1000
ToppCellwk_15-18-Epithelial-PNS-Early_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TMPRSS5 RORB RAPSN BSN

5.81e-061832947e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NR3C2 PHF3 TMIGD2 TNRC6A

6.88e-06191294696921a4f160b6b55698652488ed781e855e5e51
ToppCellCaecum-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

PEAK1 LARP4 TLR5

1.28e-057029305f8fc648641b9db50c2ae20d6246b52869957cf
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PEAK1 BTBD7 SPRING1

9.73e-05138293321070b6900887b27da0f2b25808a05a8ab89ee7
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PEAK1 BTBD7 SPRING1

9.73e-0513829319ffd66256fa94d728138d37d0a5a3bac7722dbb
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RORB NR3C2 ATXN7

1.22e-0414929348fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RORB NR3C2 ATXN7

1.30e-041522937e686721b95c837f2b0d5116927c8ecacef055ee
ToppCelldroplet-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AATK TEX14 RASAL2

1.80e-04170293dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTF2 AATK TLR5

1.83e-04171293845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCellURO-Lymphocyte-B-Plasmablast|URO / Disease, Lineage and Cell Type

AURKA TEX14 FBXO10

1.86e-0417229348888ef50ac784b38aca81da68f8a94ce09c670d
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPSN TEX14 BSN

1.90e-041732933612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPSN TEX14 BSN

1.90e-041732934dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MET TTF2 SLC39A4

1.90e-041732939dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellHealthy_donor-Plasmablast|World / disease group, cell group and cell class (v2)

AURKA MET FBXO10

1.96e-041752935293e00fda63a291aa393bdf82ebd4b80265049f
ToppCellHealthy-RBC|Healthy / disease group, cell group and cell class

AURKA TMPRSS5 RAPSN

2.03e-04177293945d72ab52efa9a9468daace9f9ec676a891d963
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS5 RAPSN BSN

2.03e-041772930417460bdb012bc43d7254377fa53d79cdab3f34
ToppCellHealthy_donor-Plasmablast|Healthy_donor / disease group, cell group and cell class (v2)

AURKA MET FBXO10

2.06e-04178293388b8b4fa20dcc6e9ae4b06118e20b2c20c52bde
ToppCelldroplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS5 NR3C2 AATK

2.06e-041782933e8aacb27ed1a3c3978e21dddddd0828f8000692
ToppCellfacs-Marrow-KLS-24m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AURKA TTF2 BSN

2.10e-041792935297f7459b40ca780a1983fecc1bb9c035c7677e
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC39A4 RAPSN TLR5

2.10e-0417929388dbec952507d84b85b08165eec80df99ed1e736
ToppCellfacs-Lung-EPCAM-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC39A4 RAPSN TLR5

2.10e-04179293daf8189a22786171e2b629261cf720736aa4ebdb
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TMPRSS5 RORB RAPSN

2.10e-04179293df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AURKA MET TNRC6A

2.10e-041792939dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AURKA SLC39A4 SPRING1

2.17e-041812938a8061725e718c89a4c751a415120c5312acc757
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MET RORB NR3C2

2.17e-0418129357994ff4ecffb15653aee00644d9f887f5e3461d
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MET RAPSN KIAA1614

2.31e-041852930094f9baddb20214d2a2c166f1637d1a9cf1169a
ToppCellfacs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS5 RAPSN AATK

2.42e-04188293794fc1d9a726945c42f7eac221eed938309b47a9
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MET RORB NR3C2

2.50e-041902931bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR3C2 LARP4 PHF3

2.54e-0419129360c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR3C2 LARP4 PHF3

2.54e-0419129309db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR3C2 LARP4 PHF3

2.54e-04191293973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MET PEAK1 RASAL2

2.58e-041922938b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellwk_15-18-Epithelial-PNS|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TMPRSS5 RORB RAPSN

2.62e-04193293ca65f8f93058ad50d89e69e06c10deeb46dbfc87
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MET RORB NR3C2

2.70e-04195293787e95fb59c40bba784544b662fac37606ae1427
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RAPSN KIAA1614 TMIGD2

2.74e-04196293bbdc92ec2e95ed7d782df0c72d94f9a9d9439bf0
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

NR3C2 PEAK1 AGAP1

2.82e-041982931996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

NR3C2 AGAP1 TNRC6A

2.86e-0419929394b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_Myelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TMPRSS5 AATK KIAA1614

2.86e-041992934e4bdcd2e8b518156d5ebd294804180acaa3566b
ToppCellSepsis-URO-Lymphocyte-B-Plasmablast|URO / Disease, condition lineage and cell class

AURKA TEX14 FBXO10

2.86e-041992930df6cafb7f3b607cbe80b6f25b4fd62d421d01ee
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial-Glia_progenitor_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

AATK PEAK1 TLR5

2.90e-042002930b91c8da21ba488109f15c9b927c1dcaf8c6b0ae
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate|6m / Sample Type, Dataset, Time_group, and Cell type.

MET RAPSN PHF3

2.90e-042002937c261e39ac30b318511373ab7302aa53b8b81b9c
ToppCellTracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TTF2 KIAA1614 SPRING1

2.90e-0420029324e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCellSigmoid-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

AURKA TEX14 PEAK1

2.90e-042002934e489ecf472857357d45e9f6c7a812aa48b72ebf
Diseasediet measurement

TTF2 TMPRSS5 NR3C2 ITCH AATK AGAP1 TNRC6A

5.53e-051049297EFO_0008111
Diseasemood instability measurement

TMPRSS5 RAPSN TNRC6A

2.68e-04128293EFO_0008475
Diseaserheumatoid arthritis, Crohn's disease

RAPSN BSN

6.41e-0438292EFO_0000384, EFO_0000685
Diseaseinvasive ductal carcinoma (is_marker_for)

AURKA MET

7.11e-0440292DOID:3008 (is_marker_for)
DiseaseMalignant neoplasm of kidney

AURKA MET

8.99e-0445292C0740457
DiseaseNeuroblastoma

AURKA MET

9.81e-0447292C0027819
Diseasebody weight

RAPSN AATK TRIP12 PHF3 AGAP1 TNRC6A

1.23e-031261296EFO_0004338
DiseaseMetastatic melanoma

AURKA PEAK1

1.29e-0354292C0278883
Diseaseanxiety

TMPRSS5 AATK SPRING1

1.35e-03223293EFO_0005230
Diseaseheart rate

NR3C2 RAPSN TNRC6A

1.38e-03225293EFO_0004326
Diseasecortical surface area measurement

NR3C2 ITCH RAPSN KIAA1614 AGAP1 TNRC6A

1.71e-031345296EFO_0010736
Diseaseneuroticism measurement

TMPRSS5 ITCH RAPSN AATK SPRING1

1.76e-03909295EFO_0007660
Diseaseneutrophil count

MET RAPSN AATK TEX14 ATXN7 TNRC6A

1.96e-031382296EFO_0004833

Protein segments in the cluster

PeptideGeneStartEntry
TTQNTCQNALGNNTR

nan

61

Q6ZS92
TPNLSRRNNNRNNSS

AGAP1

836

Q9UPQ3
SGQAQRVLCPSNSSQ

AURKA

41

O14965
SQPTRVANNSISCNR

FBXO10

766

Q9UK96
GSQRSQRSNNRSSGC

CRCT1

81

Q9UGL9
LQNNGTRSCPNCRRS

RAPSN

391

Q13702
ANINNSRCSVSSPSN

NR3C2

301

P08235
ERGNNLTQSCPNATS

NLRP8

411

Q86W28
LSTNNCNNSAPRGLQ

KIAA1614

876

Q5VZ46
QARLQQQSQPTTRGS

BSN

3796

Q9UPA5
NCLNRGQSSPQRSYS

PEAK1

711

Q9H792
PVQNGSRSRQQSSSS

RASAL2

911

Q9UJF2
RPKESSGNSTNCQNA

ATXN7

681

O15265
ENRRVSGNNSPSLSN

ITCH

231

Q96J02
SCSPRVGGNSQAQQT

BTBD7

11

Q9P203
SRASTASPCNNNINA

LARP4

591

Q71RC2
QFPNSSQNGSCRQVQ

MET

1011

P08581
VQFNLGNSSRPSNQC

SPRING1

61

Q9H741
GNSSRPSNQCRNSIQ

SPRING1

66

Q9H741
QNTSSQGRPRESTAQ

TEX14

861

Q8IWB6
NVSANNNSGSRCPES

AATK

681

Q6ZMQ8
LQQQLSGACTSQSRP

SLC39A4

301

Q6P5W5
RSCQQRDSGNSPGNA

TMIGD2

176

Q96BF3
RRSQQNNASYSCPRQ

RORB

46

Q92753
QPRNNCTSGQVVSLR

TMPRSS5

191

Q9H3S3
QDNQTSNSSPCRSNV

PHF3

1606

Q92576
RQQAQSRSSKPSNCS

ZFAND2B

241

Q8WV99
NQNRFSSCSGDQTPS

TLR5

456

O60602
NNNPGGSLRRSQRNT

TRIP12

6

Q14669
AQQQRAQSQRSVPSG

TNRC6A

1421

Q8NDV7
SQQCQGNELTRPSAS

TTF2

221

Q9UNY4