Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarbohydrate binding

ATRN MRC1 EGLN3 MRC2 GALNT9 EGLN1 GALNT12 ITLN2 CRYBG3 LY75

4.99e-073108110GO:0030246
GeneOntologyMolecularFunctionapolipoprotein receptor activity

ABCA1 LRP1

4.86e-053812GO:0030226
GeneOntologyMolecularFunctionhypoxia-inducible factor-proline dioxygenase activity

EGLN3 EGLN1

9.70e-054812GO:0160082
GeneOntologyMolecularFunctioncreatine transmembrane transporter activity

SLC16A9 SLC16A12

9.70e-054812GO:0005308
GeneOntologyMolecularFunctionpeptidyl-proline 4-dioxygenase activity

EGLN3 EGLN1

4.48e-048812GO:0031545
DomainRICIN

MRC1 MRC2 GALNT9 GALNT12 CRYBG3 LY75

1.78e-0928806SM00458
DomainRICIN_B_LECTIN

MRC1 MRC2 GALNT9 GALNT12 CRYBG3 LY75

1.78e-0928806PS50231
DomainRicin_B_lectin

MRC1 MRC2 GALNT9 GALNT12 CRYBG3 LY75

2.79e-0930806IPR000772
DomainRicin_B_lectin

MRC1 MRC2 GALNT9 GALNT12 CRYBG3

6.31e-0825805PF00652
DomainSer/Thr-sp_prot-phosphatase

PPP2CA PPP2CB PPP6C

2.10e-0513803IPR006186
DomainSER_THR_PHOSPHATASE

PPP2CA PPP2CB PPP6C

2.10e-0513803PS00125
DomainPP2Ac

PPP2CA PPP2CB PPP6C

2.10e-0513803SM00156
DomainFN_type2_col-bd

MRC1 MRC2 LY75

2.66e-0514803IPR000562
DomainFN2_2

MRC1 MRC2 LY75

2.66e-0514803PS51092
Domainfn2

MRC1 MRC2 LY75

2.66e-0514803PF00040
DomainFN2_1

MRC1 MRC2 LY75

2.66e-0514803PS00023
DomainFN2

MRC1 MRC2 LY75

2.66e-0514803SM00059
DomainFN3

IL12RB2 COL6A3 CRLF1 DSCAM ABI3BP ROS1

1.43e-04185806SM00060
DomainYIPPEE

YPEL2 YPEL1

1.80e-045802PS51792
DomainFN3

IL12RB2 COL6A3 CRLF1 DSCAM ABI3BP ROS1

2.12e-04199806PS50853
DomainCalcineurin-like_PHP_ApaH

PPP2CA PPP2CB PPP6C

2.29e-0428803IPR004843
DomainMetallophos

PPP2CA PPP2CB PPP6C

2.29e-0428803PF00149
DomainFN3_dom

IL12RB2 COL6A3 CRLF1 DSCAM ABI3BP ROS1

2.76e-04209806IPR003961
DomainMetallo-depent_PP-like

PPP2CA PPP2CB PPP6C

2.83e-0430803IPR029052
Domain-

PPP2CA PPP2CB PPP6C

2.83e-04308033.60.21.10
DomainKringle-like

MRC1 MRC2 LY75

3.43e-0432803IPR013806
DomainC_TYPE_LECTIN_1

ATRN MRC1 MRC2 LY75

3.86e-0480804PS00615
DomainLectin_C

ATRN MRC1 MRC2 LY75

4.64e-0484804PF00059
DomainCLECT

ATRN MRC1 MRC2 LY75

4.64e-0484804SM00034
DomainC_TYPE_LECTIN_2

ATRN MRC1 MRC2 LY75

4.86e-0485804PS50041
DomainYippee/Mis18/Cereblon

YPEL2 YPEL1

4.99e-048802IPR004910
DomainYippee-Mis18

YPEL2 YPEL1

4.99e-048802PF03226
DomainC-type_lectin-like

ATRN MRC1 MRC2 LY75

5.08e-0486804IPR001304
Domainfn3

IL12RB2 CRLF1 DSCAM ABI3BP ROS1

6.57e-04162805PF00041
DomainC-type_lectin_CS

MRC1 MRC2 LY75

8.25e-0443803IPR018378
DomainC-type_lectin-like/link

ATRN MRC1 MRC2 LY75

8.63e-0499804IPR016186
Domain2OG-FeII_Oxy_3

EGLN3 EGLN1

9.72e-0411802PF13640
Domain6-blade_b-propeller_TolB-like

TECPR2 LRP1 ROS1

1.01e-0346803IPR011042
DomainCTDL_fold

ATRN MRC1 MRC2 LY75

1.15e-03107804IPR016187
Domain-

MRC1 MRC2

1.37e-03138022.10.10.10
DomainWW_dom

WWOX GALNT9 IQGAP1

1.44e-0352803IPR001202
DomainTPR_8

NAA15 KDM6A CDC23

1.52e-0353803PF13181
DomainRasGAP

RASA1 IQGAP1

1.59e-0314802SM00323
DomainDynein_heavy_chain_D4_dom

DNAH14 DNAH1

1.59e-0314802IPR024317
DomainDynein_HC_stalk

DNAH14 DNAH1

1.59e-0314802IPR024743
DomainMT

DNAH14 DNAH1

1.59e-0314802PF12777
DomainAAA_8

DNAH14 DNAH1

1.59e-0314802PF12780
DomainRasGAP_CS

RASA1 IQGAP1

1.59e-0314802IPR023152
DomainLRR_6

NLRP9 CARMIL3 NLRP5

1.69e-0355803PF13516
DomainDHC_fam

DNAH14 DNAH1

1.83e-0315802IPR026983
DomainRasGAP

RASA1 IQGAP1

1.83e-0315802PF00616
DomainRAS_GTPASE_ACTIV_1

RASA1 IQGAP1

1.83e-0315802PS00509
DomainRAS_GTPASE_ACTIV_2

RASA1 IQGAP1

1.83e-0315802PS50018
DomainDynein_heavy_dom

DNAH14 DNAH1

1.83e-0315802IPR004273
DomainDynein_heavy

DNAH14 DNAH1

1.83e-0315802PF03028
DomainLY

LRP1 ROS1

1.83e-0315802SM00135
DomainLDLR_classB_rpt

LRP1 ROS1

1.83e-0315802IPR000033
Domain-

RASA1 IQGAP1

2.09e-03168021.10.506.10
DomainP4Hc

EGLN3 EGLN1

2.09e-0316802SM00702
DomainPro_4_hyd_alph

EGLN3 EGLN1

2.09e-0316802IPR006620
DomainRasGAP_dom

RASA1 IQGAP1

2.65e-0318802IPR001936
Domain2OG-FeII_Oxy

EGLN3 EGLN1

2.96e-0319802PF03171
DomainFE2OG_OXY

EGLN3 EGLN1

3.61e-0321802PS51471
DomainDAPIN

NLRP9 NLRP5

3.96e-0322802PS50824
DomainPYRIN

NLRP9 NLRP5

3.96e-0322802PF02758
DomainDAPIN

NLRP9 NLRP5

3.96e-0322802IPR004020
DomainPYRIN

NLRP9 NLRP5

3.96e-0322802SM01289
DomainNACHT

NLRP9 NLRP5

4.32e-0323802PS50837
DomainNACHT_NTPase

NLRP9 NLRP5

4.32e-0323802IPR007111
DomainOxoglu/Fe-dep_dioxygenase

EGLN3 EGLN1

4.32e-0323802IPR005123
DomainMFS_1

SLC16A9 SLC16A14 SLC16A12

4.41e-0377803PF07690
DomainMFS

SLC16A9 SLC16A14 SLC16A12

4.41e-0377803IPR011701
DomainTPR_REGION

NAA15 TTC39C KDM6A CDC23

5.52e-03165804PS50293
DomainTPR

NAA15 TTC39C KDM6A CDC23

5.52e-03165804PS50005
DomainTPR_1

NAA15 KDM6A CDC23

6.80e-0390803PF00515
DomainTPR_1

NAA15 KDM6A CDC23

6.80e-0390803IPR001440
DomainPH

RASA1 FGD4 ELMO2 PLD2 TEC

6.84e-03278805SM00233
DomainPH_DOMAIN

RASA1 FGD4 ELMO2 PLD2 TEC

6.94e-03279805PS50003
DomainPH_domain

RASA1 FGD4 ELMO2 PLD2 TEC

7.04e-03280805IPR001849
DomainGlycos_transf_2

GALNT9 GALNT12

7.29e-0330802PF00535
DomainGlyco_trans_2-like

GALNT9 GALNT12

7.29e-0330802IPR001173
Domain-

IL12RB2 COL6A3 CRLF1 DSCAM ABI3BP ROS1 TREML2 IGSF3

7.41e-036638082.60.40.10
Domain-

NLRP9 TNFRSF1A NLRP5

7.45e-03938031.10.533.10
Domain-

ATRN MRC1 MRC2

8.36e-03978033.10.100.10
Pubmed

Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals.

LIMK1 ABCA1 ROS1

5.04e-08482318566305
Pubmed

Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PPP2CA PPP2CB PPP6C

2.51e-0768239647778
Pubmed

Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation.

EGLN3 EGLN1 TNFRSF1A

7.01e-07882337400498
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ATRN TUT4 WWOX SLC16A9 RASA1 TECPR2 SLC16A14 FBXO42 LRP1 KDM6A HNRNPA2B1 ALG12 DNAH14 DNAH1 XPO7

1.86e-061489821528611215
Pubmed

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

SLC16A9 SLC16A14 SLC16A12

4.51e-061482312739169
Pubmed

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PPP2CA PPP2CB

5.49e-0628222555176
Pubmed

Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma.

EGLN3 EGLN1

5.49e-06282238400673
Pubmed

Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.

MRC1 MRC2

5.49e-06282219224860
Pubmed

Single molecule recognition between cytochrome C 551 and gold-immobilized azurin by force spectroscopy.

LIMK1 ABCA1

5.49e-06282216192283
Pubmed

Mannose receptor regulation of macrophage cell migration.

MRC1 MRC2

5.49e-06282217596337
Pubmed

Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway.

ABCA1 PLD2

5.49e-06282216118212
Pubmed

The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.

PPP2CA PPP2CB

5.49e-06282210543450
Pubmed

HIV-1 Tat represses transcription from the mannose receptor promoter.

MRC1 MRC2

5.49e-06282211120831
Pubmed

SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation.

EGLN3 EGLN1

5.49e-06282210543731
Pubmed

Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.

EGLN3 EGLN1

5.49e-06282231356139
Pubmed

IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.

IL12RB2 ABCA1

5.49e-06282218927311
Pubmed

Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.

PPP2CA PPP2CB

5.49e-06282211751260
Pubmed

Association of human mannose receptor in sexual transmission of human immunodeficiency virus in serodiscordant couples.

MRC1 MRC2

5.49e-06282223148569
Pubmed

The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor.

MRC1 MRC2

5.49e-06282217518370
Pubmed

CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor.

MRC1 MRC2

5.49e-06282215047828
Pubmed

Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.

PPP2CA PPP2CB

5.49e-06282234902541
Pubmed

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PPP2CA PPP2CB

5.49e-0628222837763
Pubmed

The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia.

EGLN3 EGLN1

5.49e-06282219737309
Pubmed

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PPP2CA PPP2CB

5.49e-0628221846293
Pubmed

Tumor necrosis factor-alpha and lymphotoxin-alpha increase macrophage ABCA1 by gene expression and protein stabilization via different receptors.

ABCA1 TNFRSF1A

5.49e-06282219913791
Pubmed

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

PPP2CA PPP2CB

5.49e-06282227096707
Pubmed

Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.

MRC1 MRC2

5.49e-06282217360361
Pubmed

Overexpression of GLP-1 receptors suppresses proliferation and cytokine release by airway smooth muscle cells of patients with chronic obstructive pulmonary disease via activation of ABCA1.

ABCA1 GLP1R

5.49e-06282228560433
Pubmed

Protein phosphatase 2A family members (PP2A and PP6) associate with U1 snRNP and the spliceosome during pre-mRNA splicing.

PPP2CA PPP6C

5.49e-06282224064353
Pubmed

Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.

PPP2CA PPP2CB

5.49e-06282211113010
Pubmed

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.

PPP2CA PPP2CB PPP6C

1.00e-051882316085932
Pubmed

Molecular oxygen sensing: implications for visceral surgery.

EGLN3 EGLN1

1.64e-05382222395314
Pubmed

HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes.

MRC1 MRC2

1.64e-05382215955449
Pubmed

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

EGLN3 EGLN1

1.64e-05382223690557
Pubmed

Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injury.

EGLN3 EGLN1

1.64e-05382232814068
Pubmed

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer.

EGLN3 EGLN1

1.64e-05382236509284
Pubmed

Characterization and comparative analysis of the EGLN gene family.

EGLN3 EGLN1

1.64e-05382211574160
Pubmed

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

EGLN3 EGLN1

1.64e-05382227561929
Pubmed

Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury.

EGLN3 EGLN1

1.64e-05382222262480
Pubmed

Loss of Prolyl-Hydroxylase 1 Protects against Biliary Fibrosis via Attenuated Activation of Hepatic Stellate Cells.

EGLN3 EGLN1

1.64e-05382230248340
Pubmed

Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na+-sensitive creatine transporter.

SLC16A9 SLC16A12

1.64e-05382231784090
Pubmed

In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte.

NLRP9 NLRP5

1.64e-05382215474461
Pubmed

Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival.

EGLN3 EGLN1

1.64e-05382221887331
Pubmed

Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.

MRC1 MRC2

1.64e-05382230366943
Pubmed

Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.

EGLN3 EGLN1

1.64e-05382224508125
Pubmed

Distribution of murine mannose receptor expression from early embryogenesis through to adulthood.

MRC1 MRC2

1.64e-0538229560474
Pubmed

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PPP2CA PPP2CB

1.64e-0538228206937
Pubmed

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.

EGLN3 EGLN1

1.64e-05382227502280
Pubmed

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.

EGLN3 EGLN1

1.64e-05382227981571
Pubmed

Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.

SLC30A8 LRP1

1.64e-05382224423473
Pubmed

Analysis of HIF-prolyl hydroxylases binding to substrates.

EGLN3 EGLN1

1.64e-05382217069766
Pubmed

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

EGLN3 EGLN1

1.64e-05382222343896
Pubmed

Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.

EGLN3 EGLN1

1.64e-05382224195777
Pubmed

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.

EGLN3 EGLN1

1.64e-05382220959442
Pubmed

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

PPP2CA PPP2CB

1.64e-0538227510677
Pubmed

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation.

EGLN3 EGLN1

1.64e-05382212234095
Pubmed

Role of the intracellular localization of HIF-prolyl hydroxylases.

EGLN3 EGLN1

1.64e-05382219339211
Pubmed

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

EGLN3 EGLN1

1.64e-05382226774962
Pubmed

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes.

EGLN3 EGLN1

1.64e-05382224037093
Pubmed

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

EGLN3 EGLN1

1.64e-05382211595184
Pubmed

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

EGLN3 EGLN1

1.64e-05382211595178
Pubmed

Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.

EGLN3 EGLN1

1.64e-05382221877141
Pubmed

The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

PPP2CA PPP6C

1.64e-05382216895907
Pubmed

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.

EGLN3 EGLN1

1.64e-05382231500697
Pubmed

Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity.

EGLN3 EGLN1

1.64e-05382217044072
Pubmed

Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans.

ABCA1 LRP1

1.64e-05382229853565
Pubmed

HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases.

MRC1 MRC2

1.64e-05382222132194
Pubmed

Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.

EGLN3 EGLN1

1.64e-05382224440788
Pubmed

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.

EGLN3 EGLN1

1.64e-05382228418093
Pubmed

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

EGLN3 EGLN1

1.64e-05382226075818
Pubmed

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

EGLN3 EGLN1

1.64e-05382222786772
Pubmed

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

EGLN3 EGLN1

1.64e-05382212615973
Pubmed

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages.

EGLN3 EGLN1

1.64e-05382228716863
Pubmed

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

EGLN3 EGLN1

1.64e-05382218063574
Pubmed

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.

EGLN3 EGLN1

1.64e-05382222615432
Pubmed

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.

PPP2CA PPP2CB

1.64e-05382210441131
Pubmed

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery.

EGLN3 EGLN1

1.64e-05382233819286
Pubmed

Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.

PPP2CA PPP2CB

1.64e-05382223341017
Pubmed

Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.

PPP2CA PPP2CB

1.64e-0538228383590
Pubmed

Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts.

EGLN3 EGLN1

1.64e-05382227614241
Pubmed

Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.

PPP2CA PPP2CB

1.64e-05382215252037
Pubmed

HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation.

EGLN3 EGLN1

1.64e-05382237140003
Pubmed

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.

EGLN3 EGLN1

1.64e-05382220600011
Pubmed

The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with Bcl-2 in non-small cell lung cancer.

EGLN3 EGLN1

3.28e-05482221748337
Pubmed

Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.

EGLN3 EGLN1

3.28e-05482220028863
Pubmed

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

EGLN3 EGLN1

3.28e-05482223264599
Pubmed

Involvement of Nlrp9a/b/c in mouse preimplantation development.

NLRP9 NLRP5

3.28e-05482232413845
Pubmed

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.

EGLN3 EGLN1

3.28e-05482218056838
Pubmed

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

PPP2CA PPP2CB

3.28e-05482211371618
Pubmed

A conserved family of prolyl-4-hydroxylases that modify HIF.

EGLN3 EGLN1

3.28e-05482211598268
Pubmed

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

PPP2CA PPP2CB

3.28e-05482221454489
Pubmed

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.

EGLN3 EGLN1

3.28e-05482222955912
Pubmed

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

EGLN3 EGLN1

3.28e-05482217646578
Pubmed

M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.

MRC1 MRC2

3.28e-05482224019537
Pubmed

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin.

LIMK1 PLD2

3.28e-05482217853892
Pubmed

A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.

ABCA1 GLP1R

3.28e-05482224493833
Pubmed

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

EGLN3 EGLN1

3.28e-05482224145445
Pubmed

The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.

PPP2CA PPP2CB

3.28e-05482214633983
Pubmed

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.

EGLN3 EGLN1

3.28e-05482212163023
Pubmed

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.

EGLN3 EGLN1

3.28e-05482212788921
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP2CA PPP2CB PPP6C

1.29e-0513663693
GeneFamilyYippee like family

YPEL2 YPEL1

1.30e-0456621130
GeneFamilyFibronectin type III domain containing

IL12RB2 CRLF1 DSCAM ABI3BP ROS1

2.95e-04160665555
GeneFamilyC-type lectin domain family

MRC1 MRC2 LY75

6.72e-0447663494
GeneFamilyDyneins, axonemal

DNAH14 DNAH1

1.72e-0317662536
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

PPP2CA PPP2CB

2.39e-03206621371
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNT9 GALNT12

2.39e-0320662433
GeneFamilyADAM metallopeptidase domain containing|CD molecules

MRC1 MRC2 LRP1 ADGRE5 TNFRSF1A LY75

3.11e-03394666471
GeneFamilyNLR family

NLRP9 NLRP5

3.73e-0325662666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP9 NLRP5

3.73e-0325662994
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

MRC1 LY75

4.34e-03276621253
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC39C KDM6A CDC23

8.58e-03115663769
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 CRLF1 DSCAM MRC2 SLC30A8 LRP1 IGSF3

4.65e-08182827f4b74c2756989812abe4e7055ec8918f69d56025
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 CRLF1 DSCAM MRC2 SLC30A8 LRP1 IGSF3

5.39e-0818682735c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 CRLF1 DSCAM MRC2 SLC30A8 LRP1 IGSF3

5.39e-08186827d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 COL6A3 DSCAM PLD2 SUCNR1 IGSF3

5.75e-07163826b83a35c4426d66b5734a98fa6c72b345fe462030
ToppCellfacs-Marrow-KLS-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 COL6A3 DSCAM PLD2 SUCNR1 IGSF3

5.75e-07163826c20ca9b6b4170ebcb0e66eef3e5d8ebff22b1a91
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 CRLF1 ABI3BP MRC2 LRP1 IGSF3

1.54e-06193826eff718664fe0aaf89050efd9cc7b6dfb1df46666
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

COL6A3 WWOX ABI3BP MRC2 LRP1 CATSPERB

1.59e-06194826234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1 MSTN

1.73e-06197826fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellCOVID-19-lung|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 ABCA1 LRP1 ADGRE5 GPRC5A ADCY7

1.84e-06199826155b03b859157013e9142e9248551369127d9204
ToppCellRV-14._Fibroblast_III|World / Chamber and Cluster_Paper

COL6A3 ABI3BP EFCAB12 PRPH2 CATSPERB

4.94e-061348258c4046ba1f85172915a112499e492c3efe8474c2
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

MRC1 ABCA1 SLC16A9 MRC2 SUCNR1

1.03e-051568259a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 UBE2O CRLF1 TECPR2 LRP1

1.17e-0516082556e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 UBE2O CRLF1 TECPR2 LRP1

1.17e-05160825bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT-iNKT/MAIT|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL12RB2 TTC39C TEC UBASH3B ADCY7

1.95e-051788257905621f5b2aa55324c5592d1d2fef763a5fa41f
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL12RB2 TTC39C TEC UBASH3B ADCY7

1.95e-05178825f914092c20130207193f97c6044ae61a9a440a86
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

COL6A3 CRLF1 ABI3BP MRC2 CATSPERB

2.01e-05179825dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

COL6A3 ABI3BP MRC2 CATSPERB GPRC5A

2.12e-051818252b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 WWOX ABI3BP TTC39C KDM6A

2.29e-05184825d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

COL6A3 CRLF1 ABI3BP MRC2 LRP1

2.35e-051858258f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK3 COL6A3 ABI3BP LRP1 UBASH3B

2.35e-051858253b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL6B ABI3BP MRC2 LRP1 GPRC5A

2.67e-05190825990ac07f4b0a22041daac7502f74fafd6d258cba
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

COL6A3 EGLN3 ABI3BP CATSPERB ERI2

2.67e-0519082512992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL6B ABI3BP MRC2 LRP1 GPRC5A

2.67e-05190825fc9bbe5e6e0ec3cfa47bf479d8b09a0fc53169cc
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL6B ABI3BP MRC2 LRP1 GPRC5A

2.67e-0519082539ecdf8815e235771132684dfc1aff1917e20965
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 IL12RB2 ABCA1 LRP1 ADCY7

2.74e-0519182551f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 IL12RB2 ABCA1 LRP1 ADCY7

2.74e-051918258fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCellfacs-Aorta-Heart-18m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 IGSF3

2.74e-051918256242f83acaf1714e9c1771a832cb67674b19e96d
ToppCellRV-01._Fibroblast_I|World / Chamber and Cluster_Paper

COL6A3 EGLN3 ABI3BP MRC2 CATSPERB

2.74e-0519182570c067c54084bfb02c29bab085f4defd477194fb
ToppCelldroplet-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 CRLF1 ABI3BP MRC2 LRP1

2.81e-0519282538d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCellfacs-Aorta-Heart-18m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 IGSF3

2.81e-051928256d4fe7ea278efa4b9d43f8a3c282bc0e0e9abaea
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 GNRHR

2.81e-05192825853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 CRLF1 ABI3BP MRC2 LRP1

2.81e-0519282504d155897ed075c359933080e36a4ab2150b6e9f
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 IGSF3

2.81e-051928252c6406bc97c3224099b94a43f2890f057b528fa6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRE5 TNFRSF1A GPRC5A UBASH3B IQGAP1

2.81e-051928258b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 GNRHR

2.81e-05192825d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

COL6A3 ABI3BP MRC2 LRP1 SLC16A12

2.81e-0519282560b1312e84f6d6448365a952469c506c00b5fe93
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 CRLF1 ABI3BP MRC2 LRP1

2.81e-0519282584149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 IGSF3

2.81e-0519282547aed7c8e6f5ce1084821212a04f568319e65fd6
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 GNRHR

2.81e-0519282549281626ecad0456fdbded2378b7028d7b589686
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCA1 WWOX RASA1 FGD4 KDM6A

2.88e-05193825779276e775cb2492e8dd36436295a536084a6415
ToppCellLV-02._Fibroblast_II|LV / Chamber and Cluster_Paper

COL6A3 CRLF1 ABI3BP MRC2 CATSPERB

2.95e-05194825014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL6A3 CRLF1 ABI3BP LRP1 GPRC5A

2.95e-0519482569362e13158033de44f90f3773db6c0f27de8cb3
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

COL6A3 CRLF1 ABI3BP MRC2 LRP1

2.95e-05194825d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL6A3 ABI3BP MRC2 LRP1 SLC16A12

2.95e-0519482560622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 IL12RB2 ABCA1 LRP1 ADCY7

2.95e-051948251dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

MRC1 ABCA1 LRP1 UBASH3B ADCY7

3.02e-05195825148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellRV-02._Fibroblast_II|World / Chamber and Cluster_Paper

COL6A3 WWOX ABI3BP MRC2 CATSPERB

3.02e-05195825ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

COL6A3 ABI3BP MRC2 LRP1 CATSPERB

3.02e-051958256a02ebbeb3199447ddce64d92d8809436e040eba
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ABI3BP MRC2 LRP1 MSTN

3.10e-05196825fcb275746bf51269ed8ba4cf93edb054a45f1ccd
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 ABCA1 ABI3BP LRP1 CRYBG3

3.10e-051968252ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 ABCA1 LRP1 UBASH3B ADCY7

3.10e-051968257026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellRA-02._Fibroblast_II|World / Chamber and Cluster_Paper

COL6A3 ABI3BP MRC2 CATSPERB GPRC5A

3.10e-05196825e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.18e-0519782571786e9432e2d649f5d86f639abb25e7102deb67
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ABCA1 ABI3BP FXYD4 ITLN2 GPRC5A

3.18e-0519782569d5b8588046d119b5dff9a7fd6f49e97e00a5b7
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ABCA1 ABI3BP FXYD4 ITLN2 GPRC5A

3.18e-05197825e6cbfa267eb2e05b441fd034786faae07bb0e081
ToppCellBiopsy_IPF-Epithelial-AT1|Biopsy_IPF / Sample group, Lineage and Cell type

ABI3BP MRC2 FXYD4 ITLN2 GPRC5A

3.25e-0519882575bdecbe111fededf6082b11de18b84ca308ef6d
ToppCelldistal-mesenchymal-Adventitial_Fibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

COL6A3 ABI3BP MRC2 PRPH2 SLC16A12

3.25e-05198825bfd720e2dae3b6b3dc2bf8b2096c554fd456e756
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.33e-05199825ba586690f88fd051f449753bfe7603a2cb431782
ToppCell368C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL6A3 ABI3BP LRP1 TNFRSF1A GPRC5A

3.33e-051998258766796041965a1ba40ad7abdbc244bf1418c209
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.33e-0519982506a7d874ff7c4616577f6e59d3118717a8c47c00
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.33e-051998259672230aa0bc6a7289050c955f5154ca183a5159
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.33e-05199825fde2b65afde69f402f1b7b056eaa266e9fd5b227
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.33e-05199825e18abe678da293bd01fae55e2f9ab6fdd643d02d
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.33e-05199825a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellLPS_only-Mesenchymal_fibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.33e-05199825211c3a08f2d484ab7a3368006767289088f0d957
ToppCelldistal-2-mesenchymal-Adventitial_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

COL6A3 ABI3BP MRC2 PRPH2 SLC16A12

3.33e-0519982597b475f9110ef7bb29d9cf2109b7e43177830f05
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.33e-051998251fd7bbb8727607e6507848602a19bc86882ef2d5
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.33e-051998258b86c69aaf60feff53aa782559cfece7342a23de
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts|LPS_only / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.33e-051998251a0add79f4e34078b3475eb11c85a4234bda197c
ToppCell368C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

COL6A3 ABI3BP LRP1 TNFRSF1A GPRC5A

3.33e-05199825d39b40d84c72bdde756b805063317ecfad3784f8
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.41e-0520082517ffdbc13332bd3ed1d54abcd7af20267dd4b234
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

MRC1 FGD4 LRP1 TNFRSF1A IQGAP1

3.41e-05200825e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.41e-05200825665df8391d2ebcfc6536318612f4992852b5e2b8
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.41e-0520082544317fbf4d1480a37b50ab2777bf1a3e4fc0c05f
ToppCellBiopsy_IPF-Epithelial-KRT5-/KRT17+|Biopsy_IPF / Sample group, Lineage and Cell type

DOCK3 CRLF1 ROS1 GPRC5A IGSF3

3.41e-052008252fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.41e-05200825a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellcellseq2-Mesenchymal-Fibroblastic|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.41e-052008251c10597edd532bf172ca09870a937d35e2585081
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.41e-05200825bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A3 ABCA1 ABI3BP MRC2 LRP1

3.41e-052008250c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_1|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 CRLF1 ABI3BP MRC2 LRP1

3.41e-05200825440dda48b09c6a8581b7ca634b0d67f1ecacf65e
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GALNT12 ACSBG2 TTPA NLRP5

8.93e-051278245b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCelldroplet-Tongue-Unstain-18m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGD4 GPRC5A UBASH3B MAP3K6

1.07e-04133824f7d0763b5eec2db33044d6850fd57462494038c1
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP|Cerebellum / BrainAtlas - Mouse McCarroll V32

COL6A3 MRC2 GALNT12 GPRC5A

1.65e-041498243980fa4f1986a2f164a1826ea043fb71f1d756cd
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TAF1A PLD2 CRYBG3 ALG12

1.70e-041508246f7087a051a2f05c5611ff65a945c01736d5ec2b
ToppCell390C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MRC2 TAF1A TEC DNAH1

1.78e-04152824ebce79e106bf1d84241f8dd3496ff1771f9666be
ToppCell390C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MRC2 TAF1A TEC DNAH1

1.78e-041528244a749d1b6d35fd55a8c42d7bd04b6ff5b11ce781
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

COL6A3 MRC2 GALNT12 SLC16A12

1.88e-0415482465dbb60f636562eeba3dafadae9c0c7db2b27476
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC16A9 TTC39C FBXO42 TNFRSF1A

1.97e-04156824895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A9 PLD2 ADCY7 IQGAP1

2.02e-04157824ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellfacs-Marrow-B-cells-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 CARMIL3 LRP1 GNRHR

2.02e-041578240966e347f8d32b13f8a3b3afba3f64637c69cdf9
ToppCellfacs-Marrow-B-cells-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 CARMIL3 LRP1 GNRHR

2.02e-041578246ebfedd91d62c6d4aa8f046657a899a279f82ba2
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 TTC39C GALNT9 IQGAP1

2.17e-041608241f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ABCA1 UBE2O LRP1

2.17e-041608240544bc465af208da448858d6e174ff56f2e08a46
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UBE2O TEC UBASH3B TREML2

2.22e-0416182452556b89808e551540f33a13f57417a6696c2438
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UBE2O TEC UBASH3B TREML2

2.22e-0416182454f156cf2bd5a6ba9a78ec4e3ee28b89998aec2e
ToppCellfacs-Spleen-nan-3m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 FGD4 LRP1 SUCNR1

2.22e-0416182445591addc765760db6029ac19e80573373d1d917
ToppCellfacs-Spleen-nan-3m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 FGD4 LRP1 SUCNR1

2.22e-041618248741b91a62c9a8ce377ef6533d323b65beb93c63
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UBE2O TEC UBASH3B TREML2

2.22e-04161824242891be849a4398fe8bea44875ae1ba57950944
ToppCellfacs-Spleen-nan-3m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 FGD4 LRP1 SUCNR1

2.22e-041618249cf1dcf0e7ca9e35c46c094a6b78f98d1f6b9276
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 UBE2O CRLF1 LRP1

2.22e-0416182460f433eab9d5531bdf6aa86b0265f20b866b904c
Drugdimethyloxalylglycine; Up 200; 1000uM; PC3; HG-U133A

UBE2O GLP1R FBXO42 EGLN1 LRP1 GPRC5A YPEL1

2.48e-06172807584_UP
DrugTiletamine hydrochloride; Up 200; 15.4uM; HL60; HT_HG-U133A

DSCAM ABI3BP LRP1 PRPH2 PLD2 YPEL1 ALG12

6.49e-061998073137_UP
DrugGA 7

EGLN3 NAA15 EGLN1

1.16e-0513803CID000092782
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

4.12e-054782EFO_0020830
Diseasemyocardial infarction (biomarker_via_orthology)

EGLN3 EGLN1 TNFRSF1A KDM6A

8.69e-04160784DOID:5844 (biomarker_via_orthology)
Diseasesphingosine 1-phosphate measurement

UBE2O KDM6A

1.03e-0318782EFO_0800185
Diseasecystathionine measurement

TEC TEC

1.15e-0319782EFO_0010474
Diseasereasoning

EGLN3 WWOX

1.15e-0319782EFO_0004350
Diseasemyeloperoxidase (MPO)-DNA complex measurement

YPEL2 CATSPERB

1.54e-0322782EFO_0011039
DiseasePigmented Basal Cell Carcinoma

PPP6C RASA1

2.49e-0328782C1368275

Protein segments in the cluster

PeptideGeneStartEntry
KKWEILNFNQYYEAC

ACSBG2

76

Q5FVE4
KYQENRKCCGYFKWE

ERI2

626

A8K979
KVLECHWEKYNNRYT

EDDM3A

101

Q14507
LNQLVEAKKCYWRAY

CDC23

446

Q9UJX2
LAQYYFKCKLWDEAS

CDC23

516

Q9UJX2
YVKGKLWYNERCFAN

CATSPERB

291

Q9H7T0
QIWYYCRGLFKSKAS

CRYBG3

2876

Q68DQ2
GLKIKSLNWYEDNNY

ABCA1

316

O95477
EYRKWACLVAGGSKY

ADGRE5

796

P48960
QIDYYCRLDCLWKKK

ADCY7

816

P51828
NFLVYLQCWKLCKSY

EFCAB12

391

Q6NXP0
ITCIYYLNKNWDAKL

EGLN3

146

Q9H6Z9
RGCSYLLNNYKKSWL

ALG12

326

Q9BV10
CIQSQWRGYKQKKAY

IQGAP1

781

P46940
KYYRLCDKAEAWGIV

GPRC5A

16

Q8NFJ5
RYIYGCLQKSVQHKW

RASA1

871

P20936
KQWYRLIKGVAHQCY

FBXO42

76

Q6P3S6
TYFCKQLAKRKWQLY

SLC16A9

276

Q7RTY1
QLAKRKWQLYKNYCG

SLC16A9

281

Q7RTY1
KWQLYKNYCGETVAL

SLC16A9

286

Q7RTY1
SLNYWCNLLGMKIYE

GLOD4

166

Q9HC38
IVKYLYEDEGCWTRN

GLP1R

286

P43220
QEICNRYDKKYSWDV

PUDP

31

Q08623
KCRSFKWYLENVYPE

GALNT9

441

Q9HCQ5
YQDGKLYWCDARTDK

LRP1

2061

Q07954
EEKYKTFNKYWCRQP

CD300H

46

A0A0K2S4Q6
NYKYKTKCTWLIEGQ

ATRN

151

O75882
NLTWQKQCKDIYCDY

IL12RB2

166

Q99665
ACQYKLAVERYEWNK

KDM6A

1246

O15550
LAYNQWFTKLYCKDL

CARMIL3

211

Q8ND23
LARKGCVEKMQYYWD

MAP3K6

426

O95382
GYVVCWKCSDYKAQL

FGD4

586

Q96M96
TTLNYEYDRKWGICL

LY75

196

O60449
QGWASDTKLRYCYKV

MRC2

671

Q9UBG0
SSYGLQWCLYELDKE

NLRP5

61

P59047
DECLRKYGNANVWKY

PPP2CB

131

P62714
DECLRKYGNANVWKY

PPP2CA

131

P67775
YDEAIKCYRNALKWD

NAA15

96

Q9BXJ9
QKLKYKWCEVGVLDY

DNAH1

296

Q9P2D7
GSWDKCKFYVNKYLV

EFCAB5

1401

A4FU69
GKYQCVAELWRKNYN

IGSF3

641

O75054
ACNWKKYKYIVLNSQ

BCL6B

191

Q8N143
GALAYKELIRCLKWY

DOCK3

696

Q8IZD9
QWYAGELLCKVLSYL

GNRHR

106

P30968
NKYEYCIWIDGLSAL

ELMO2

651

Q96JJ3
CIYSKNEKWLSIAYG

CLPSL1

91

A2RUU4
CRDFILKWYYDPNTK

COL6A3

3121

P12111
LKWYYDPNTKSCARF

COL6A3

3126

P12111
WNPLCKEKKYDYDNL

GALNT12

121

Q8IXK2
YKWNEKQKLCYVSQG

DNAH14

1106

Q0VDD8
CIYYLNKDWDAKVSG

EGLN1

326

Q9GZT9
KYPVKYRSGKCWNDN

ITLN2

201

Q8WWU7
WNLYGKCRYRCSKKE

DEFB123

26

Q8N688
LKYKLRWYGQDNTCE

CRLF1

171

O75462
LKSACVYLDLDGYWK

MRC1

1186

P22897
YRLENLKCGTWYKFT

DSCAM

1436

O60469
YYDWKNLQLSGLICG

FXYD4

31

P59646
CSYKGYKNRVEGKVW

TREML2

41

Q5T2D2
GKKSNNLDQYEWYCR

TEC

236

P42680
TVLLKYLCAEYGWRN

SLC16A14

176

Q7RTX9
FGWLTDRRCLKNYQY

SLC16A12

336

Q6ZSM3
GCTKNITAWKYLAKY

TAF1A

341

Q15573
DWIIAPKRYKANYCS

MSTN

296

O14793
NYRKCRIKLSGYAWV

CCNB1IP1

11

Q9NPC3
SGCISDYNEKLVYWR

NLRP9

606

Q7RTR0
DIYCENCKTTLGWKY

YPEL1

76

O60688
EKGANEYAYAKWKLC

SLC30A8

61

Q8IWU4
SLRNYYEQWGKLTDC

HNRNPA2B1

36

P22626
TKYGNANAWRYCTKV

PPP6C

131

O00743
ICYDALDPAKYARWK

PRPH2

81

P23942
YDCWLGKVYDLKNQI

UBE2O

206

Q9C0C9
DYWAMLAYNRSKLCN

WWOX

286

Q9NZC7
WEKAEDNGCRITYYI

ROS1

1771

P08922
LVVSEKYIWCLDYKG

TECPR2

816

O15040
KNYYKWRAECPEISA

TTPA

71

P49638
CKNWLAAEAALEKYY

SUCNR1

11

Q9BXA5
DIYCENCKTTLGWKY

YPEL2

76

Q96QA6
LYARITKLGWFDCQK

XPO7

111

Q9UIA9
KYWLSQCFDAKGRYI

UBASH3B

401

Q8TF42
WKIYNKCYLDINALQ

TTC39C

166

Q8N584
SYSECKGKQYVKRTW

ABI3BP

951

Q7Z7G0
RYWAKLCYIDSQTDG

TUT4

501

Q5TAX3
LKAHKQGWCYRVYVL

PLD2

666

O14939
YQRWKSKLYSIVCGK

TNFRSF1A

236

P19438
KDGQLFCKKDYWARY

LIMK1

66

P53667