Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of microtubule binding	PPP2CA PPP2CB	3.12e-05	5	37	2	GO:1904528
GeneOntologyBiologicalProcess	regulation of microtubule binding	PPP2CA PPP2CB	1.12e-04	9	37	2	GO:1904526
GeneOntologyCellularComponent	FAR/SIN/STRIPAK complex	PPP2CA PPP2CB	4.08e-04	17	37	2	GO:0090443
GeneOntologyCellularComponent	protein phosphatase type 2A complex	PPP2CA PPP2CB	4.58e-04	18	37	2	GO:0000159
Domain	Calcineurin-like_PHP_ApaH	PPP2CA PPP2CB SMPD1	2.46e-05	28	38	3	IPR004843
Domain	Metallophos	PPP2CA PPP2CB SMPD1	2.46e-05	28	38	3	PF00149
Domain	Metallo-depent_PP-like	PPP2CA PPP2CB SMPD1	3.04e-05	30	38	3	IPR029052
Domain	-	PPP2CA PPP2CB SMPD1	3.04e-05	30	38	3	3.60.21.10
Domain	Ser/Thr-sp_prot-phosphatase	PPP2CA PPP2CB	3.10e-04	13	38	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP2CA PPP2CB	3.10e-04	13	38	2	PS00125
Domain	PP2Ac	PPP2CA PPP2CB	3.10e-04	13	38	2	SM00156
Domain	Zinc_finger_PHD-type_CS	JADE2 CXXC1	7.73e-03	65	38	2	IPR019786
Pathway	REACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS	PPP2CA PPP2CB	9.13e-05	7	30	2	M26992
Pathway	REACTOME_MASTL_FACILITATES_MITOTIC_PROGRESSION	PPP2CA PPP2CB	1.95e-04	10	30	2	M27176
Pathway	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	PPP2CA PPP2CB	1.95e-04	10	30	2	MM14509
Pathway	REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	PPP2CA PPP2CB	2.85e-04	12	30	2	M27950
Pathway	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	PPP2CA PPP2CB	3.37e-04	13	30	2	M1015
Pathway	REACTOME_ERKS_ARE_INACTIVATED	PPP2CA PPP2CB	3.37e-04	13	30	2	MM14811
Pathway	WP_DOPAMINE_METABOLISM	PPP2CA PPP2CB	3.37e-04	13	30	2	M39622
Pathway	REACTOME_ERKS_ARE_INACTIVATED	PPP2CA PPP2CB	3.37e-04	13	30	2	M8410
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	PPP2CA PPP2CB IL17RB	4.51e-04	71	30	3	M27382
Pathway	REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS	PPP2CA PPP2CB	4.52e-04	15	30	2	M27407
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE	PPP2CA PPP2CB	5.16e-04	16	30	2	M47870
Pathway	REACTOME_DARPP_32_EVENTS	PPP2CA PPP2CB	5.16e-04	16	30	2	MM14699
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	PPP2CA PPP2CB	5.16e-04	16	30	2	MM14541
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	PPP2CA PPP2CB	5.16e-04	16	30	2	M514
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2CA PPP2CB	5.84e-04	17	30	2	MM15096
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2CA PPP2CB	5.84e-04	17	30	2	M27083
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2CA PPP2CB	5.84e-04	17	30	2	M919
Pathway	REACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX	PPP2CA PPP2CB PSMB3	6.17e-04	79	30	3	MM14754
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2CA PPP2CB	6.56e-04	18	30	2	MM14759
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	PPP2CA PPP2CB	7.32e-04	19	30	2	M47525
Pathway	REACTOME_ERK_MAPK_TARGETS	PPP2CA PPP2CB	7.32e-04	19	30	2	MM14780
Pathway	REACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX	PPP2CA PPP2CB PSMB3	7.64e-04	85	30	3	M27079
Pathway	REACTOME_GLUCOSE_METABOLISM	PPP2CA PPP2CB NUP210	7.64e-04	85	30	3	M1870
Pathway	KEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING	PPP2CA PPP2CB	8.12e-04	20	30	2	M47876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2CA PPP2CB	8.97e-04	21	30	2	M5876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2CA PPP2CB	8.97e-04	21	30	2	MM14996
Pathway	REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION	PPP2CA PPP2CB	9.85e-04	22	30	2	M6768
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY	PPP2CA PPP2CB	9.85e-04	22	30	2	M47919
Pathway	REACTOME_ERK_MAPK_TARGETS	PPP2CA PPP2CB	9.85e-04	22	30	2	M13408
Pathway	REACTOME_DARPP_32_EVENTS	PPP2CA PPP2CB	1.17e-03	24	30	2	M751
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	PPP2CA PPP2CB	1.27e-03	25	30	2	MM15379
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	PPP2CA PPP2CB	1.27e-03	25	30	2	M808
Pathway	REACTOME_G1_S_TRANSITION	PPP2CA PPP2CB PSMB3	1.37e-03	104	30	3	MM15376
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	PPP2CA PPP2CB	1.49e-03	27	30	2	MM14779
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	PPP2CA PPP2CB	1.60e-03	28	30	2	MM15132
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING	PPP2CA PPP2CB	1.72e-03	29	30	2	M27528
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING	PPP2CA PPP2CB	1.72e-03	29	30	2	MM15253
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	PPP2CA PPP2CB	1.96e-03	31	30	2	M27400
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING	PPP2CA PPP2CB	1.96e-03	31	30	2	M27529
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING	PPP2CA PPP2CB	1.96e-03	31	30	2	MM15254
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	PPP2CA PPP2CB	1.96e-03	31	30	2	MM15154
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	PPP2CA PPP2CB	1.96e-03	31	30	2	M15195
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING	PPP2CA PPP2CB	2.22e-03	33	30	2	M27526
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING	PPP2CA PPP2CB	2.22e-03	33	30	2	MM15252
Pathway	REACTOME_SIGNALING_BY_WNT_IN_CANCER	PPP2CA PPP2CB	2.35e-03	34	30	2	M27405
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING	PPP2CA PPP2CB	2.35e-03	34	30	2	M27527
Pathway	REACTOME_RAF_ACTIVATION	PPP2CA PPP2CB	2.35e-03	34	30	2	M27556
Pathway	WP_GLYCOGEN_METABOLISM	PPP2CA PPP2CB	2.35e-03	34	30	2	MM15985
Pathway	WP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME	PPP2CA PPP2CB	2.35e-03	34	30	2	M42555
Pathway	REACTOME_RAF_ACTIVATION	PPP2CA PPP2CB	2.49e-03	35	30	2	MM15271
Pathway	REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION	PPP2CA PPP2CB PSMB3	2.59e-03	130	30	3	MM15146
Pathway	REACTOME_REGULATION_OF_TP53_DEGRADATION	PPP2CA PPP2CB	2.64e-03	36	30	2	MM15339
Pathway	REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION	PPP2CA PPP2CB	2.78e-03	37	30	2	M27641
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	PPP2CA PPP2CB CHPF2 NUP210	3.08e-03	288	30	4	M16864
Pathway	REACTOME_SIGNALING_BY_FGFR3	PPP2CA PPP2CB	3.09e-03	39	30	2	MM15257
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	PPP2CA PPP2CB	3.25e-03	40	30	2	M39595
Pathway	REACTOME_SIGNALING_BY_FGFR3	PPP2CA PPP2CB	3.25e-03	40	30	2	M27532
Pathway	REACTOME_SIGNALING_BY_FGFR4	PPP2CA PPP2CB	3.25e-03	40	30	2	MM15258
Pathway	REACTOME_MITOTIC_PROPHASE	PPP2CA PPP2CB NUP210	3.33e-03	142	30	3	M27660
Pathway	REACTOME_SIGNALING_BY_FGFR4	PPP2CA PPP2CB	3.41e-03	41	30	2	M27533
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY	PPP2CA PPP2CB	3.58e-03	42	30	2	MM15274
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY	PPP2CA PPP2CB	3.74e-03	43	30	2	M27560
Pathway	REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION	PPP2CA PPP2CB PSMB3	3.81e-03	149	30	3	M848
Pathway	REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1	PPP2CA PPP2CB	3.92e-03	44	30	2	MM15377
Pathway	KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM	FCSK PGM3	3.92e-03	44	30	2	M8104
Pathway	REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	PPP2CA PPP2CB NUP210	3.96e-03	151	30	3	M550
Pathway	REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1	PPP2CA PPP2CB	4.46e-03	47	30	2	M29724
Pathway	REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT	PPP2CA PPP2CB PSMB3	4.49e-03	158	30	3	MM14791
Pathway	REACTOME_SIGNALING_BY_FGFR1	PPP2CA PPP2CB	5.03e-03	50	30	2	MM15255
Pubmed	Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.	PPP2CA PPP2CB	1.16e-06	2	38	2	2837763
Pubmed	Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.	PPP2CA PPP2CB	1.16e-06	2	38	2	1846293
Pubmed	Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.	PPP2CA PPP2CB	1.16e-06	2	38	2	2555176
Pubmed	PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.	PPP2CA PPP2CB	1.16e-06	2	38	2	27096707
Pubmed	The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.	PPP2CA PPP2CB	1.16e-06	2	38	2	10543450
Pubmed	Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.	PPP2CA PPP2CB	1.16e-06	2	38	2	11751260
Pubmed	Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.	PPP2CA PPP2CB	1.16e-06	2	38	2	11113010
Pubmed	Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.	PPP2CA PPP2CB	1.16e-06	2	38	2	34902541
Pubmed	Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.	PPP2CA PPP2CB	3.48e-06	3	38	2	7510677
Pubmed	The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.	PPP2CA PPP2CB	3.48e-06	3	38	2	8206937
Pubmed	Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.	PPP2CA PPP2CB	3.48e-06	3	38	2	10441131
Pubmed	Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.	PPP2CA PPP2CB	3.48e-06	3	38	2	23341017
Pubmed	Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.	PPP2CA PPP2CB	3.48e-06	3	38	2	8383590
Pubmed	Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.	PPP2CA PPP2CB	3.48e-06	3	38	2	15252037
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DISP2 KATNIP CHPF2 KIAA0513 CSMD3 SIPA1L1	4.98e-06	407	38	6	12693553
Pubmed	Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.	PPP2CA PPP2CB	6.96e-06	4	38	2	21998041
Pubmed	Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.	PPP2CA PPP2CB	6.96e-06	4	38	2	9770493
Pubmed	Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.	PPP2CA PPP2CB	6.96e-06	4	38	2	7616230
Pubmed	Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.	PPP2CA PPP2CB	6.96e-06	4	38	2	9920888
Pubmed	Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.	PPP2CA PPP2CB	6.96e-06	4	38	2	11371618
Pubmed	The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.	PPP2CA PPP2CB	6.96e-06	4	38	2	21454489
Pubmed	The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.	PPP2CA PPP2CB	6.96e-06	4	38	2	14633983
Pubmed	HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.	PPP2CA PPP2CB	1.16e-05	5	38	2	9009195
Pubmed	Protein phosphatase 2A interacts with and directly dephosphorylates RelA.	PPP2CA PPP2CB	1.16e-05	5	38	2	11591705
Pubmed	Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.	PPP2CA PPP2CB	1.16e-05	5	38	2	10640627
Pubmed	Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.	PPP2CA PPP2CB	1.16e-05	5	38	2	18596935
Pubmed	Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.	PPP2CA PPP2CB	1.74e-05	6	38	2	10781942
Pubmed	Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.	PPP2CA PPP2CB	1.74e-05	6	38	2	20100830
Pubmed	Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.	PPP2CA PPP2CB	1.74e-05	6	38	2	29735529
Pubmed	Alpha 4 associates with protein phosphatases 2A, 4, and 6.	PPP2CA PPP2CB	1.74e-05	6	38	2	9647778
Pubmed	Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.	PPP2CA PPP2CB	1.74e-05	6	38	2	15147202
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	PPP2CA PPP2CB	1.74e-05	6	38	2	25531779
Pubmed	GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.	PPP2CA PPP2CB	2.43e-05	7	38	2	10698523
Pubmed	Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.	PPP2CA PPP2CB	2.43e-05	7	38	2	17604273
Pubmed	The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.	PPP2CA PPP2CB	2.43e-05	7	38	2	25546391
Pubmed	X-linked microtubule-associated protein, Mid1, regulates axon development.	PPP2CA PPP2CB	2.43e-05	7	38	2	24194544
Pubmed	p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].	PPP2CA PPP2CB	3.24e-05	8	38	2	1330687
Pubmed	Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.	PPP2CA PPP2CB	3.24e-05	8	38	2	11007961
Pubmed	Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.	PPP2CA PPP2CB	3.24e-05	8	38	2	12912990
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP2CA PPP2CB	3.24e-05	8	38	2	16262633
Pubmed	Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.	PPP2CA PPP2CB	3.24e-05	8	38	2	35768646
Pubmed	Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.	PPP2CA PPP2CB	3.24e-05	8	38	2	12370081
Pubmed	Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.	PPP2CA PPP2CB	3.24e-05	8	38	2	23462102
Pubmed	Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.	PPP2CA PPP2CB	4.16e-05	9	38	2	18432318
Pubmed	Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.	PPP2CA PPP2CB	4.16e-05	9	38	2	12885400
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	PPP2CA PPP2CB F5 NEXMIF	6.34e-05	197	38	4	20811636
Pubmed	MARF1 regulates essential oogenic processes in mice.	PPP2CA PPP2CB	6.35e-05	11	38	2	22442484
Pubmed	Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.	PPP2CA PPP2CB	7.62e-05	12	38	2	11259605
Pubmed	PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.	PPP2CA PPP2CB	7.62e-05	12	38	2	34079065
Pubmed	Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.	PPP2CA PPP2CB	7.62e-05	12	38	2	12435421
Pubmed	Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.	PPP2CA PPP2CB	9.00e-05	13	38	2	18971272
Pubmed	PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.	PPP2CA PPP2CB	9.00e-05	13	38	2	21072166
Pubmed	PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.	PPP2CA PPP2CB	9.00e-05	13	38	2	16717086
Pubmed	Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.	PPP2CA PPP2CB	1.05e-04	14	38	2	9013886
Pubmed	Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.	PPP2CA PPP2CB	1.05e-04	14	38	2	9400615
Pubmed	Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway.	PPP2CA PPP2CB	1.21e-04	15	38	2	38474134
Pubmed	Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu.	PPP2CA PPP2CB	1.38e-04	16	38	2	23047923
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP2CA PPP2CB	1.56e-04	17	38	2	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP2CA PPP2CB	1.56e-04	17	38	2	21351466
Pubmed	Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.	PPP2CA PPP2CB	1.76e-04	18	38	2	23287597
Pubmed	A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.	PPP2CA PPP2CB	1.76e-04	18	38	2	16085932
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	PPP2CB IL17RB NUP210 PNPO	1.76e-04	257	38	4	30945288
Pubmed	Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.	PPP2CA PPP2CB	1.96e-04	19	38	2	32582689
Pubmed	Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.	PPP2CA PPP2CB	1.96e-04	19	38	2	26389696
Pubmed	Shugoshin collaborates with protein phosphatase 2A to protect cohesin.	PPP2CA PPP2CB	1.96e-04	19	38	2	16541025
Pubmed	Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.	PPP2CA PPP2CB	2.18e-04	20	38	2	21514445
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	MR1 GXYLT1 CHPF2 SMPD1 FAT1 PLXNB1 NUP210	2.84e-04	1201	38	7	35696571
Pubmed	Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.	PPP2CA PPP2CB	2.90e-04	23	38	2	26644582
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	FCSK PPP2CA PPP2CB PSMB3	3.34e-04	304	38	4	32235678
Pubmed	The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.	PPP2CA PPP2CB	3.43e-04	25	38	2	34004147
Pubmed	HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.	PPP2CA PPP2CB	3.72e-04	26	38	2	11531413
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	TRMT1 PPP2CB TSPYL1 MYO6 PGM3 NUP210 PSMB3	3.74e-04	1257	38	7	37317656
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ARHGAP32 KATNIP SIPA1L1	3.91e-04	130	38	3	12421765
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	FCSK PPP2CA PPP2CB NUP210 PSMB3	4.93e-04	606	38	5	36538041
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	PPP2CA PPP2CB MYO6 NUP210 PSMB3	6.63e-04	647	38	5	26618866
Pubmed	Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.	PPP2CA PPP2CB	7.15e-04	36	38	2	22422068
Pubmed	Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.	PPP2CA PPP2CB	7.56e-04	37	38	2	26811472
Pubmed	Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.	PPP2CA PPP2CB	8.83e-04	40	38	2	23555304
Pubmed	Roles of tau protein in health and disease.	PPP2CA PPP2CB	8.83e-04	40	38	2	28386764
Pubmed	URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells.	PPP2CA PPP2CB	9.74e-04	42	38	2	27780869
Pubmed	Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.	PPP2CA PPP2CB	9.74e-04	42	38	2	29028833
Cytoband	5q31.1	PPP2CA JADE2	1.26e-03	63	38	2	5q31.1
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP2CA PPP2CB	1.09e-04	13	22	2	693
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	PPP2CA PPP2CB	2.65e-04	20	22	2	1371
GeneFamily	PHD finger proteins	JADE2 CXXC1	5.31e-03	90	22	2	88
Disease	Global developmental delay	TRMT1 FCSK PPP2CA PNPO	2.59e-05	133	38	4	C0557874
Disease	Feeding difficulties	FCSK PPP2CA	2.44e-04	18	38	2	C0232466
Disease	sensorineural hearing loss (is_implicated_in)	MYO6 F5	8.31e-04	33	38	2	DOID:10003 (is_implicated_in)
Disease	peripheral arterial disease	CSMD3 F5	2.22e-03	54	38	2	EFO_0004265
Disease	Intellectual Disability	TRMT1 FCSK PPP2CA PGM3	2.55e-03	447	38	4	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
VDPLGEMLAPSWEEH	PGM3	76	O95394
PHWERGEESAVMLEP	CPQ	111	Q9Y646
LPLAEGMDRDLWIHE	C8orf74	151	Q6P047
HDILRVWDGPPENDM	CSMD3	1466	Q7Z407
HLMPDGSLPEAQSLW	SMPD1	611	P17405
LPWRGEFHPDTLQMA	AP4B1	646	Q9Y6B7
MWASRDHLPEPDLGD	CBY3	1	A6NI87
EVSHWLAAELGMAPP	DISP2	926	A7MBM2
ESLWEPNMDPDHLFE	PSMB3	151	P49720
DMGESPSHPSWDQDR	KIAA0513	56	O60268
LRVWDAEHPGLSDFM	NUP210	1456	Q8TEM1
PEGTVIMWLEAHDPD	FAT1	941	Q14517
DEHMWLIPFSPGLDH	KATNIP	1281	O60303
SPEWMLQHDLIPGDL	IL17RB	31	Q9NRM6
AMSEWPLNNGHREDP	JADE2	546	Q9NQC1
PMLEDVDEGGIRPWH	PLXNB1	1871	O43157
IAAMAPEHEEPRIGW	GXYLT1	241	Q4G148
SPLGPMTHRGEEDWL	PNPO	241	Q9NVS9
HEGPMCDLLWSDPDD	PPP2CB	191	P62714
HEGPMCDLLWSDPDD	PPP2CA	191	P67775
HPRERPDWEETLSAM	ARHGAP32	61	A7KAX9
GPQDLLWMLDHQEDG	FCSK	501	Q8N0W3
DHGLPWMSDTEESPF	CXXC1	301	Q9P0U4
SDALAPLDDSMPWEG	GNRH2	71	O43555
EPRAPWMAENLAPDH	MR1	66	Q95460
PREDEMAADGDKPWG	FSCN2	156	O14926
PMWAEPIHDLDFVGR	TRMT1	396	Q9NXH9
LPSMDFGWIASLPDH	F5	1086	P12259
ASIEPLWEPMEHHGD	NEXMIF	1336	Q5QGS0
GLMPLPDTAADLDWS	SIPA1L1	1666	O43166
PPMDWEALEKHLAGL	IQCJ-SCHIP1	296	B3KU38
HGDERPAWLMSETLR	CHPF2	151	Q9P2E5
SETEDMLWDDLLHGP	PHTF1	376	Q9UMS5
EEEGPWPLHEALRMD	TSPYL1	216	Q9H0U9
MWHRRASPEPDAAAA	SH2B2	151	O14492
EDAESWHAKPMPRER	TKTL1	226	P51854
MELREEAWSPGPLDS	ZNF787	1	Q6DD87
FDGPWIARQMELHPD	MYO6	1206	Q9UM54