Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentAtg1/ULK1 kinase complex

TBC1D5 SESN2

2.24e-049532GO:1990316
GeneOntologyCellularComponentnucleotide-activated protein kinase complex

PRKAG3 SESN2

3.42e-0411532GO:0031588
DomainEamA_dom

SLC35G3 SLC35G5 SLC35G6 SLC35G4

5.66e-0814534IPR000620
DomainEamA

SLC35G3 SLC35G5 SLC35G6 SLC35G4

5.66e-0814534PF00892
Domain-

ASPN XRRA1 TSHR LRRC75A NXF1

2.12e-033215353.80.10.10
DomainL_dom-like

ASPN XRRA1 TSHR LRRC75A NXF1

2.33e-03328535IPR032675
DomainLRR_1

ASPN XRRA1 TSHR NXF1

3.44e-03219534PF00560
DomainIon_trans_dom

TRPM5 TRPV4 KCNS3

4.16e-03114533IPR005821
DomainIon_trans

TRPM5 TRPV4 KCNS3

4.16e-03114533PF00520
DomainLeu-rich_rpt

ASPN XRRA1 TSHR NXF1

7.27e-03271534IPR001611
Domain-

KRBA2 POLN

7.87e-03475323.30.420.10
PathwayREACTOME_RND1_GTPASE_CYCLE

RND1 UBXN11 RBM39 PLXNA1 TFRC

1.26e-0743405MM15679
PathwayREACTOME_RND1_GTPASE_CYCLE

RND1 UBXN11 PLXNA1 TFRC

5.75e-0642404M41828
PathwayREACTOME_RND2_GTPASE_CYCLE

FNBP1 UBXN11 RBM39 TFRC

6.95e-0644404MM15678
PathwayREACTOME_RHO_GTPASE_CYCLE

FNBP1 RND1 UBXN11 KALRN RBM39 PLXNA1 TFRC

2.07e-04439407MM15595
PathwayREACTOME_RND2_GTPASE_CYCLE

FNBP1 UBXN11 TFRC

2.41e-0443403M41827
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

FNBP1 RND1 UBXN11 CENPA KALRN RBM39 PLXNA1 TFRC

4.02e-04649408MM15690
PathwayWP_BIOMARKERS_FOR_UREA_CYCLE_DISORDERS

GPT ARG1

5.09e-0412402M39842
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

RND1 PLXNA1

6.99e-0414402M7578
Pubmed

RT-PCR of fatty acid elongases.

SLC35G3 SLC35G5 SLC35G6 SLC35G4

5.19e-1245449056918
Pubmed

Emergence of primate genes by retrotransposon-mediated sequence transduction.

SLC35G3 SLC35G5 SLC35G6 SLC35G4

5.19e-12454417101974
Pubmed

Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.

COMMD10 MED23

2.37e-06254230250136
Pubmed

Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.

RND1 UBXN11

1.42e-05454211940653
Pubmed

A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.

KNDC1 UNC79

2.36e-05554216807365
Pubmed

Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching.

FNBP1 RND1

3.54e-05654214732713
Pubmed

The semaphorin 3A receptor may directly regulate the activity of small GTPases.

RND1 PLXNA1

6.59e-05854211108845
Pubmed

Age-associated features of norovirus infection analysed in mice.

CD300LF COMMD10

8.46e-05954237188813
Pubmed

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.

TRPM5 ARG1

1.29e-041154229887373
Pubmed

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity.

TRPM5 ARG1

1.55e-041254232160525
Pubmed

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.

COMMD10 TFRC

1.83e-041354220080761
Pubmed

DELE1 is protective for mitochondrial cardiomyopathy.

NPPA SESN2

3.17e-041754236539111
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

NRM AFG3L2 FASTKD5 PLXNA1 TFRC CDC45

3.69e-0461354622268729
Pubmed

Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.

KALRN NELFA RBM39

3.78e-049054331280863
Pubmed

Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.

SESN2 CDC45

3.98e-041954219805316
Pubmed

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.

TBC1D5 COMMD10

3.98e-041954237172566
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

NRM ERCC4 ZKSCAN1 TBC1D5 AFG3L2 FASTKD5 MED23 TFRC

5.07e-04120354829180619
Pubmed

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.

NPPA NELFA

5.36e-042254219015276
Pubmed

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

MED23 RBM39 NXF1

5.77e-0410454326167872
Pubmed

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.

ERCC4 MED23 RBM39

6.26e-0410754320508642
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM5 TRPV4

6.39e-042454233884443
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

KDM5B CD300LF TBC1D5 XRRA1 POLN HYDIN

6.66e-0468654629987050
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM5 TRPV4

6.94e-042554216382100
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

NPPA TBC1D5 MED23 RBM39 TFRC

7.14e-0445754532968282
Pubmed

Specification of CNS macrophage subsets occurs postnatally in defined niches.

COMMD10 TFRC

8.10e-042754235444273
Pubmed

An introduction to TRP channels.

TRPM5 TRPV4

8.10e-042754216460286
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

NSUN5 AFG3L2 FASTKD5 RBM39 NXF1

9.40e-0448654530940648
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM5 TRPV4

1.21e-033354219834762
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

KALRN AFG3L2 GPT KNDC1

1.28e-0330454432235678
Pubmed

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.

MMP19 PLXNA1

1.36e-033554216452166
Pubmed

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.

CENPA CDC45

1.44e-033654226167883
Cytoband17p13.1

KRBA2 MFSD6L SLC35G6

3.73e-0411854317p13.1
CytobandEnsembl 112 genes in cytogenetic band chr17p13

KRBA2 MFSD6L SLC35G6 TLCD2

7.45e-04346544chr17p13
GeneFamilyTransient receptor potential cation channels

TRPM5 TRPV4

1.33e-0328352249
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

UBXN11 SESN2 MMP19 ERICH6 TFRC

4.37e-0620054588d713dfc792e7609bf7ecfb28f87cb748088570
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Vipr2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CENPA KCNS3 SESN2 TSHR

1.33e-051195446425425b2e622c97b6c74c530ccbfe394d3b202d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPPA CENPA MAN1C1 KCNS3

4.14e-05159544c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM5 CD300LF PLEKHO2 KCNS3

5.37e-0517054417bd7fd25a2657cb536ad47e294332920f759e95
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD300LF PLEKHO2 LRRC75A TFRC

5.62e-05172544c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD300LF GPT PLXNA1 ARG1

5.75e-0517354420f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM5 CD300LF KALRN ERICH6

6.01e-05175544f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP97D2 TSHR HYDIN ERICH6

6.42e-05178544579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP97D2 TSHR HYDIN ERICH6

6.42e-05178544b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCellP03-Epithelial-airway_epithelial_cell-club_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFAP97D2 UBXN11 KNDC1 HYDIN

6.85e-0518154460a91587c59029a34e7bec1255083337fe21b72a
ToppCellfacs-Lung-EPCAM-24m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP97D2 UBXN11 SLC35G3 HYDIN

7.30e-05184544afb11ab301ef9801333dbb53ccff4bd0d44f1677
ToppCellfacs-Lung-EPCAM-24m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP97D2 UBXN11 SLC35G3 HYDIN

7.30e-05184544a411c0bcb283534a1c15f22473c46b7d87e01294
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RND1 MAN1C1 TSHR CDC45

7.45e-0518554453854a9ec87c24c360541c83d86d8fafb303ad58
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RND1 MAN1C1 TSHR CDC45

7.45e-05185544a61fc7a3700a1efcf640bef7680c0443ee148a46
ToppCellCiliated-cil-2|World / Class top

CFAP97D2 UBXN11 SLC35G3 HYDIN

7.77e-05187544e2e58ba039b5355c03c3b448e750aa37b0ea6913
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP97D2 UBXN11 KNDC1 MFSD6L

7.77e-05187544888856cde7a69ea2f14d590597e25b1af6383c51
ToppCellfacs-Lung-EPCAM-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP97D2 UBXN11 KNDC1 MFSD6L

7.77e-05187544051b8c07d7489ce7576f6c57ce7008767ef76869
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

TRPM5 CD300LF KCNS3

8.10e-056954354e5ede00ce2920158d1cc0ac8e718aa24a4342e
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)|Cerebellum / BrainAtlas - Mouse McCarroll V32

TRPM5 CD300LF KCNS3

8.10e-0569543c93a47ee777b560f69b705d5d597f3cb3a3f558a
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

TRPM5 CD300LF KCNS3

8.10e-05695438946d7e433c232c56563a6c464152c0a8cdbdf92
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFAP97D2 UBXN11 KNDC1 MFSD6L

8.26e-051905449ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFAP97D2 UBXN11 KNDC1 MFSD6L

8.26e-051905443ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P1-P1_1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

TRPM5 XRRA1 ERICH6

8.45e-0570543ee86e3790ff1fd684b7dff8c9de70e75133e9046
ToppCellCiliated-cil-3|World / Class top

CFAP97D2 UBXN11 KNDC1 HYDIN

8.60e-051925444989ebb8812b8af1870599acd932849122c05a29
ToppCellParenchymal-10x5prime-Immune_Myeloid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

UBXN11 CD300LF MMP19 TFRC

1.01e-04200544d5b26580c84a7c942407786a67b20027986679fc
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

UBXN11 CD300LF MMP19 TFRC

1.01e-04200544d7d971586c01152b3d21956fd98280588cb8f08b
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasmablast|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CENPA TSHR CDC45

1.08e-0476543df1c29cf88b1957e210058e172683f78a1eea2bd
DiseaseL-arginine measurement

KCNS3 MED23 ARG1

1.55e-0527533EFO_0006524
DiseaseUrination Disorders

NPPA TRPV4

1.89e-054532C0042035
Diseaseacute kidney failure (biomarker_via_orthology)

NPPA GPT ARG1

1.83e-0461533DOID:3021 (biomarker_via_orthology)
Diseasearginine measurement

MED23 ARG1

7.82e-0423532EFO_0020990
Diseaseimmature platelet fraction

KALRN PLEKHO2 TBC1D5

1.14e-03114533EFO_0009187
Diseaseimmature platelet measurement

KALRN PLEKHO2 TBC1D5

1.29e-03119533EFO_0803541

Protein segments in the cluster

PeptideGeneStartEntry
KLRLLLEKLSRFHAK

GPT

476

P24298
LKSKLRALLTAPRSL

NPPA

111

P01160
LLASLIKIRRLFHKL

ERICH6

596

Q7L0X2
RLLKFLHIFGSLLPR

PRKAG3

326

Q9UGI9
IFKVHLRPLKLDSTL

AFG3L2

486

Q9Y4W6
IHPKAFLTTKKLRRL

ASPN

141

Q9BXN1
LSYLLGRKKRPIHLS

ARG1

216

P05089
KLKLHLLSQRNSLPR

POLN

491

Q7Z5Q5
KIGLPHSIKLSRRRS

RBM39

111

Q14498
SAGLLRAEKKLRPHL

NSUN5

56

Q96P11
AVKLKLLLGTLHLPR

NELFA

51

Q9H3P2
FLLSLRKRSPKQGHL

LRRC75A

281

Q8NAA5
PRLLTRILQKLHLKA

COMMD10

31

Q9Y6G5
LLHPFKATLLRKLSR

MFSD6L

416

Q8IWD5
LLTKKHFLLTFIRTL

PLXNA1

1361

Q9UIW2
KDPTLRFRLLKHTRL

NXF1

446

Q9UBU9
KKHLTFRILNLPSTL

MMP19

106

Q99542
PKSLIRKGRERHLFL

KALRN

1486

O60229
LKPALKLRLRFITHI

MED23

1321

Q9ULK4
LALKSPRALRLFSHL

NRM

181

Q8IXM6
STLLRFPHTRLGKLL

KCNS3

31

Q9BQ31
KSLLKARPRHSLNSL

KDM5B

976

Q9UGL1
SRPASLSLLSKHLLK

CDC45

461

O75419
LPLLKRTRLEKLAFL

FASTKD5

741

Q7L8L6
PLLLFKRLLLGHSEK

HYDIN

3491

Q4G0P3
KRLLLGHSEKLPLIL

HYDIN

3496

Q4G0P3
IHCFRSLKRGLSLKL

FNBP1

381

Q96RU3
KSTHLLIRKLPFSRL

CENPA

56

P49450
LDNRHKLLKLSVLLP

CD300LF

146

Q8TDQ1
RAPLTFRHLHLKLKR

CFAP97D2

41

A0A1B0GU71
FLLPHSSRLKRLFLA

MAN1C1

41

Q9NR34
NHKLALPRRLKTLLL

KNDC1

546

Q76NI1
DHSTKFIILRPLRTK

KRBA2

286

Q6ZNG9
RCLFHLPIALLLKLR

SLC35G5

76

Q96KT7
LLGLHRAPEKLRKLS

SESN2

146

P58004
RCLFHLPIALLLKLR

SLC35G3

76

Q8N808
QKSPVRSLSKRLLHL

RND1

196

Q92730
SHTLPALLENLKLRK

TFRC

706

P02786
RCLFHLPIALLLKLR

SLC35G4

76

P0C7Q5
SLKINHPKTLFLLRG

PPP3CC

131

P48454
HLRKLLLLSRQAPSL

TLCD2

146

A6NGC4
LLSHLSLTLRRVFKK

TRPM5

1016

Q9NZQ8
PLLSLLLLALHKFLR

VSTM2B

266

A6NLU5
HYKRLARSTLLLIPL

SCTR

336

P47872
RCLFHLPIALLLKLR

SLC35G6

76

P0C7Q6
LPLKKRNLDLFVFRH

ZDHHC21

161

Q8IVQ6
ALLKRKHRFILLRSP

PLEKHO2

76

Q8TD55
SKLTLLTLHFPRLRI

ERCC4

786

Q92889
VHSLILKALFLRDPK

TBC1D5

401

Q92609
KHSSRKPRLLQSRAL

ZKSCAN1

181

P17029
LDGLLPFLLTHKKRL

TRPV4

166

Q9HBA0
FASLAGLRRLKKLSL

XRRA1

246

Q6P2D8
ALLLRARRAPKSSLK

UBXN11

466

Q5T124
KKLPLSLSFLHLTRA

TSHR

261

P16473
RPTILSKLLLLHFLK

UNC79

1141

Q9P2D8