Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	multi-eIF complex	EIF1AY EIF1AX EIF3A	1.62e-06	4	156	3	GO:0043614
GeneOntologyCellularComponent	contractile ring	MAEA KIF20B PDXP	1.40e-04	14	156	3	GO:0070938
GeneOntologyCellularComponent	eukaryotic 48S preinitiation complex	EIF1AY EIF1AX EIF3A	3.06e-04	18	156	3	GO:0033290
GeneOntologyCellularComponent	eukaryotic 43S preinitiation complex	EIF1AY EIF1AX EIF3A	3.62e-04	19	156	3	GO:0016282
GeneOntologyCellularComponent	translation preinitiation complex	EIF1AY EIF1AX EIF3A	4.23e-04	20	156	3	GO:0070993
Domain	ARM-type_fold	PDS5B ZYG11A NOC2L LRRK2 USP9Y RYR3 AP4E1 PIK3CG PDS5A CTNND2 STAG2 TBCD ARMC6	5.99e-06	339	157	13	IPR016024
Domain	DH_1	RASGRF2 ARHGEF18 ALS2 ECT2 ARHGEF40 VAV2	1.47e-05	63	157	6	PS00741
Domain	RhoGEF	RASGRF2 ARHGEF18 ALS2 ECT2 ARHGEF40 VAV2	2.70e-05	70	157	6	PF00621
Domain	DH_2	RASGRF2 ARHGEF18 ALS2 ECT2 ARHGEF40 VAV2	2.70e-05	70	157	6	PS50010
Domain	-	RASGRF2 ARHGEF18 ALS2 ECT2 ARHGEF40 VAV2	2.93e-05	71	157	6	1.20.900.10
Domain	DH-domain	RASGRF2 ARHGEF18 ALS2 ECT2 ARHGEF40 VAV2	2.93e-05	71	157	6	IPR000219
Domain	KRAB	ZNF234 ZNF658 ZNF460 ZNF862 ZNF226 ZNF230 ZNF550 ZNF732 ZNF589 ZNF84 ZNF418 ZNF726	5.17e-05	358	157	12	PS50805
Domain	KRAB	ZNF234 ZNF658 ZNF460 ZNF862 ZNF226 ZNF230 ZNF550 ZNF732 ZNF589 ZNF84 ZNF418 ZNF726	5.17e-05	358	157	12	PF01352
Domain	KRAB	ZNF234 ZNF658 ZNF460 ZNF862 ZNF226 ZNF230 ZNF550 ZNF732 ZNF589 ZNF84 ZNF418 ZNF726	6.90e-05	369	157	12	SM00349
Domain	TIF_eIF-1A_CS	EIF1AY EIF1AX	7.02e-05	2	157	2	IPR018104
Domain	KRAB	ZNF234 ZNF658 ZNF460 ZNF862 ZNF226 ZNF230 ZNF550 ZNF732 ZNF589 ZNF84 ZNF418 ZNF726	7.08e-05	370	157	12	IPR001909
Domain	aa-tRNA-synt_IIb	GARS1 HARS2 EIF2AK4	9.15e-05	11	157	3	IPR002314
Domain	-	GARS1 HARS2 EIF2AK4	9.15e-05	11	157	3	3.40.50.800
Domain	tRNA-synt_2b	GARS1 HARS2 EIF2AK4	9.15e-05	11	157	3	PF00587
Domain	ARM-like	PDS5B ZYG11A LRRK2 USP9Y AP4E1 PDS5A CTNND2 STAG2 TBCD ARMC6	9.80e-05	270	157	10	IPR011989
Domain	Anticodon-bd	GARS1 HARS2 EIF2AK4	1.98e-04	14	157	3	IPR004154
Domain	RIG-I_C-RD	DHX58 IFIH1	2.09e-04	3	157	2	IPR021673
Domain	TIF_eIF-1A	EIF1AY EIF1AX	2.09e-04	3	157	2	PD005579
Domain	RIG-I_C-RD	DHX58 IFIH1	2.09e-04	3	157	2	PF11648
Domain	RLR_CTR	DHX58 IFIH1	2.09e-04	3	157	2	PS51789
Domain	IF1A	EIF1AY EIF1AX	2.09e-04	3	157	2	PS01262
Domain	BBOX	TRIM21 TRIM39 TRIM5 TRIM45 TRIM44	2.87e-04	69	157	5	SM00336
Domain	-	TRIM21 TRIM39 TRIM5 TRIM45 TRIM44	3.28e-04	71	157	5	4.10.45.10
Domain	zf-B_box	TRIM21 TRIM39 TRIM5 TRIM45 TRIM44	3.50e-04	72	157	5	PF00643
Domain	S1_IF1_TYPE	EIF1AY EIF1AX	4.17e-04	4	157	2	PS50832
Domain	TIF_eIF-1A	EIF1AY EIF1AX	4.17e-04	4	157	2	IPR001253
Domain	eIF1a	EIF1AY EIF1AX	4.17e-04	4	157	2	SM00652
Domain	RNA-binding_domain_S1_IF1	EIF1AY EIF1AX	4.17e-04	4	157	2	IPR006196
Domain	eIF-1a	EIF1AY EIF1AX	4.17e-04	4	157	2	PF01176
Domain	aa-tRNA-synth_II	GARS1 HARS2 EIF2AK4	4.33e-04	18	157	3	IPR006195
Domain	AA_TRNA_LIGASE_II	GARS1 HARS2 EIF2AK4	4.33e-04	18	157	3	PS50862
Domain	ZF_BBOX	TRIM21 TRIM39 TRIM5 TRIM45 TRIM44	5.70e-04	80	157	5	PS50119
Domain	-	PDS5B ZYG11A LRRK2 AP4E1 PDS5A CTNND2 TBCD ARMC6	5.89e-04	222	157	8	1.25.10.10
Domain	Znf_B-box	TRIM21 TRIM39 TRIM5 TRIM45 TRIM44	6.03e-04	81	157	5	IPR000315
Pathway	KEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION	PDS5B PDS5A STAG2	1.95e-05	7	118	3	M47869
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	TRAF6 RASGRF2 ARHGEF18 ECT2 ARHGEF40 VAV2	4.11e-05	76	118	6	M19832
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B PDS5A STAG2	6.57e-05	10	118	3	M27178
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B PDS5A STAG2	6.57e-05	10	118	3	MM14892
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B PDS5A STAG2	8.98e-05	11	118	3	M27177
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B PDS5A STAG2	8.98e-05	11	118	3	MM14891
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	RASGRF2 ARHGEF18 ECT2 ARHGEF40 VAV2	1.32e-04	59	118	5	M11215
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B PDS5A STAG2	1.54e-04	13	118	3	MM15363
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B PDS5A STAG2	1.54e-04	13	118	3	M27661
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	TRAF6 RASGRF2 ARHGEF18 ECT2 ARHGEF40 VAV2	1.61e-04	97	118	6	M9400
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	TRAF6 RASGRF2 ARHGEF18 ECT2 VAV2	2.96e-04	70	118	5	MM14824
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	TRAF6 RASGRF2 ARHGEF18 ECT2 CFLAR ARHGEF40 VAV2	3.10e-04	154	118	7	M27697
Pathway	KEGG_AMINOACYL_TRNA_BIOSYNTHESIS	GARS1 FARSB HARS2 IARS2	3.72e-04	41	118	4	M14691
Pathway	REACTOME_TRNA_AMINOACYLATION	GARS1 FARSB HARS2 IARS2	4.08e-04	42	118	4	M456
Pathway	REACTOME_S_PHASE	PDS5B RBL2 PSMD6 LIG1 PDS5A CDC6 STAG2	4.37e-04	163	118	7	M3158
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	FARSB ALS2 DYSF ECT2 BIRC6 GFPT1 EIF1AY EFNA1 CDK5RAP2 STAG2 TPD52L2	9.44e-07	363	158	11	14691545
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ESPN CACNA1C KLF8 ABAT MBLAC2 MAEA TMEM63B ARHGEF18 ITPKB PTPN4 EFNA1 TESMIN COQ8A GCC2 ZNF589 KLHL23 EIF2AK4 ZNF84 CROCC STAG2 VAV2 TBCD	1.15e-06	1489	158	22	28611215
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	IMPDH2 MAEA GARS1 VPS33A POLR2H FARSB TRIM21 THOC2 ECT2 BIRC6 ELAC2 GFPT1 PSMD6 IARS2 COQ8A GCAT TFB2M CDC6 TBCD ARMC6	1.21e-06	1257	158	20	37317656
Pubmed	Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.	PDS5B PDS5A STAG2	3.18e-06	7	158	3	15855230
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PDS5B CACNA1C RASGRF2 USP9Y DYSF NSUN7 RYR3 IFIH1 FBXO22 ZFR KDM4A EIF2AK4	3.18e-06	497	158	12	36774506
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDS5B IMPDH2 NOC2L GARS1 POLR2H CGAS FARSB CAT ECT2 BIRC6 ELAC2 KIF20B GFPT1 CHCHD3 ARHGEF40 FBXO22 PDS5A ZFR EIF3A ZMYM3	3.67e-06	1353	158	20	29467282
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	METTL3 IMPDH2 NOC2L BCLAF1 GARS1 CGAS FARSB CAT TRIM21 THOC2 ECT2 KIF20B GFPT1 HARS2 CHCHD3 IARS2 ZFR EIF3A TFB2M	4.77e-06	1257	158	19	36526897
Pubmed	Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.	PDS5B PDS5A STAG2	5.07e-06	8	158	3	29867216
Pubmed	Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions.	PDS5B PDS5A STAG2	5.07e-06	8	158	3	21699228
Pubmed	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.	PDS5B PDS5A STAG2	7.57e-06	9	158	3	16682347
Pubmed	Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.	PDS5B PDS5A STAG2	7.57e-06	9	158	3	17349791
Pubmed	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.	PDS5B PDS5A STAG2	7.57e-06	9	158	3	17112726
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	TRAF6 RASGRF2 ARHGEF18 ECT2 VAV2	8.11e-06	60	158	5	12787561
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	PDS5B PDS5A STAG2	1.08e-05	10	158	3	22751501
Pubmed	Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.	PDS5B PDS5A STAG2	1.08e-05	10	158	3	23242214
Pubmed	Wapl controls the dynamic association of cohesin with chromatin.	PDS5B PDS5A STAG2	1.48e-05	11	158	3	17113138
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ESPN PDS5B TRAF6 ARHGEF18 TRIM21 USP37 KDM4E ELAC2 CYFIP2 TRIM45 AP4E1 EFNA1 PIK3CG SULT1C3 CDK5RAP2 DLG2 CDC6 TPD52L2	1.52e-05	1242	158	18	30973865
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	REXO5 ZNF460 MAEA ZNF550 ZNF589 ZNF84 ZNF726	2.03e-05	181	158	7	37372979
Pubmed	Retinoic acid-inducible gene 1-like receptors in the upper respiratory tract.	DHX58 IFIH1	2.05e-05	2	158	2	22185736
Pubmed	PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.	PDS5B PDS5A	2.05e-05	2	158	2	31757807
Pubmed	Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.	BCLAF1 CFLAR	2.05e-05	2	158	2	34693625
Pubmed	A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2.	DHX58 IFIH1	2.05e-05	2	158	2	19403670
Pubmed	Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing.	DHX58 IFIH1	2.05e-05	2	158	2	38309507
Pubmed	Ubiquitination of cGAS by TRAF6 regulates anti-DNA viral innate immune responses.	TRAF6 CGAS	2.05e-05	2	158	2	31078259
Pubmed	Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.	CACNA1C RYR3	2.05e-05	2	158	2	24026422
Pubmed	PDS5A and PDS5B in Cohesin Function and Human Disease.	PDS5B PDS5A	2.05e-05	2	158	2	34070827
Pubmed	Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.	DHX58 IFIH1	2.05e-05	2	158	2	28090671
Pubmed	Roles for ELMOD2 and Rootletin in ciliogenesis.	ELMOD2 CROCC	2.05e-05	2	158	2	33596093
Pubmed	Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice.	CACNA1C METTL3	2.05e-05	2	158	2	35130614
Pubmed	Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibition.	DHX58 IFIH1	2.05e-05	2	158	2	24829334
Pubmed	SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.	FBXO22 KDM4A	2.05e-05	2	158	2	21768309
Pubmed	SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.	FBXO22 KDM4A	2.05e-05	2	158	2	26868148
Pubmed	Spatiotemporal dynamics of innate immune signaling via RIG-I-like receptors.	DHX58 IFIH1	2.05e-05	2	158	2	32571931
Pubmed	Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication.	DHX58 IFIH1	2.05e-05	2	158	2	36152765
Pubmed	PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.	PDS5B PDS5A	2.05e-05	2	158	2	35986423
Pubmed	Ro52/SSA sensitizes cells to death receptor-induced apoptosis by down-regulating c-FLIP(L).	TRIM21 CFLAR	2.05e-05	2	158	2	22288650
Pubmed	The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.	DHX58 IFIH1	2.05e-05	2	158	2	25127512
Pubmed	Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population.	DHX58 IFIH1	2.05e-05	2	158	2	36743960
Pubmed	Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.	DHX58 IFIH1	2.05e-05	2	158	2	24550253
Pubmed	Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease.	LRRK2 MUC19	2.05e-05	2	158	2	19714762
Pubmed	LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling.	DHX58 IFIH1	2.05e-05	2	158	2	25794939
Pubmed	Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells.	DHX58 IFIH1	2.05e-05	2	158	2	28483922
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	TRAF6 GALE IMPDH2 GARS1 FARSB GFPT1 IARS2	2.10e-05	182	158	7	30711629
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	PDS5B ZNF460 BCLAF1 GARS1 TMEM63B ECT2 TRIM5 CHCHD3 PPIL1 CDK5RAP2 PDS5A ZFR EIF3A CDC6 STAG2 ZMYM3 TBCD	2.18e-05	1155	158	17	20360068
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GAD2 TRAF6 ZNF234 RBL2 SMG5 USP9Y IDS FAM53C GFPT1 TRIM5 RYR3 CHCHD3 EFNA1 SLF2 DLG2 KDM4A ZNF84 CTNND2	2.38e-05	1285	158	18	35914814
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	RASGRF2 ARHGEF18 ECT2 VAV2	2.68e-05	38	158	4	11756498
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	IMPDH2 GARS1 VPS33A FARSB CAT BIRC6 ELAC2 GFPT1 PSMD6 ARHGEF40 FBXO22 GCAT SORBS3 PDS5A ZFR EIF3A CROCC ARMC6	2.68e-05	1297	158	18	33545068
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PDS5B IMPDH2 ELMOD2 ZNF658 ZNF460 NOC2L BCLAF1 CAT THOC2 ONECUT1 CYFIP2 PSMD6 PDS5A ZNF319 MNT ZMYM3 TBCD	3.64e-05	1203	158	17	29180619
Pubmed	The tripartite motif family identifies cell compartments.	TRIM21 TRIM39 TRIM5 TRIM44	3.64e-05	41	158	4	11331580
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	DYNC2H1 VPS33A FARSB GFPT1 ITPKB CHCHD3 COQ8A GCC2 PLCB1 CDK5RAP2 CTNND2 STAG2	3.79e-05	638	158	12	31182584
Pubmed	Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.	PDS5B PDS5A STAG2	4.02e-05	15	158	3	23901111
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	RASGRF2 ARHGEF18 ECT2 VAV2	4.41e-05	43	158	4	12376548
Pubmed	HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation.	USP9Y EIF1AY	6.13e-05	3	158	2	22158087
Pubmed	Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.	DHX58 IFIH1	6.13e-05	3	158	2	19211564
Pubmed	Nonencapsidated 5' Copy-Back Defective Interfering Genomes Produced by Recombinant Measles Viruses Are Recognized by RIG-I and LGP2 but Not MDA5.	DHX58 IFIH1	6.13e-05	3	158	2	28768856
Pubmed	Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.	DHX58 IFIH1	6.13e-05	3	158	2	16116171
Pubmed	The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production.	TRIM21 TRIM5	6.13e-05	3	158	2	21264255
Pubmed	The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.	KDM4E KDM4A	6.13e-05	3	158	2	21555854
Pubmed	Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.	PDS5B PDS5A	6.13e-05	3	158	2	28343969
Pubmed	TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.	CGAS TRIM21	6.13e-05	3	158	2	26506431
Pubmed	STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection.	CGAS STAG2	6.13e-05	3	158	2	29662124
Pubmed	Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.	PDS5B PDS5A	6.13e-05	3	158	2	24141881
Pubmed	Genome wide association study: searching for genes underlying body mass index in the Chinese.	AKR1E2 EIF2AK4	6.13e-05	3	158	2	24827717
Pubmed	Activation-induced degradation of FLIP(L) is mediated via the phosphatidylinositol 3-kinase/Akt signaling pathway in macrophages.	CFLAR PIK3CG	6.13e-05	3	158	2	19339247
Pubmed	LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.	DHX58 IFIH1	6.13e-05	3	158	2	20080593
Pubmed	RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.	DHX58 IFIH1	6.13e-05	3	158	2	31409781
Pubmed	PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2.	DHX58 IFIH1	6.13e-05	3	158	2	29032202
Pubmed	The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.	EIF1AY EIF1AX	6.13e-05	3	158	2	24319994
Pubmed	LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA.	DHX58 IFIH1	6.13e-05	3	158	2	23671710
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PDS5B IMPDH2 DYNC2H1 NOC2L BCLAF1 GARS1 FARSB THOC2 GFPT1 CYFIP2 PSMD6 CHCHD3 IARS2 KLHL23 PDS5A ZFR EIF3A STAG2	8.98e-05	1425	158	18	30948266
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	NUDT19 ABAT SNPH GARS1 ELAC2 CKMT2 HARS2 CHCHD3 TMTC1 IARS2 COQ8A GCAT FASTK TFB2M	9.05e-05	926	158	14	20877624
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF234 ZNF226 ZNF230	9.91e-05	20	158	3	12743021
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ESPN PDS5B CACNA1C ZNF658 NOC2L BCLAF1 GARS1 CAT CYFIP2 CHCHD3 TESMIN DLG2 ZFR EIF3A EIF2AK4 ZNF84 STAG2 ERICH6	1.04e-04	1442	158	18	35575683
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PDS5B IMPDH2 DYNC2H1 NOC2L PEX1 FARSB GFPT1 CHCHD3 ARHGEF40 PDXP PDS5A STAG2 ZMYM3 TBCD	1.08e-04	942	158	14	31073040
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDS5B SNPH TMEM94 VPS8 ALS2 GCC2 ZNF319 CROCC ZMYM3	1.09e-04	407	158	9	12693553
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	IMPDH2 DYNC2H1 POLR2H PEX1 PSMD6 IARS2 COQ8A GCAT PDS5A TFB2M TBCD	1.10e-04	606	158	11	36538041
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	IMPDH2 GARS1 FARSB CAT ELAC2 GFPT1 IARS2 EIF1AX ZFR EIF3A TBCD	1.12e-04	607	158	11	39147351
Pubmed	ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.	DHX58 IFIH1	1.22e-04	4	158	2	33727702
Pubmed	Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients.	DHX58 IFIH1	1.22e-04	4	158	2	25288302
Pubmed	RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium.	DHX58 IFIH1	1.22e-04	4	158	2	21187438
Pubmed	METTL3 aggravates cell damage induced by Streptococcus pneumoniae via the NEAT1/CTCF/MUC19 axis.	METTL3 MUC19	1.22e-04	4	158	2	38757482
Pubmed	Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.	EFNA1 VAV2	1.22e-04	4	158	2	16782872
Pubmed	Antiretroviral potential of human tripartite motif-5 and related proteins.	TRIM21 TRIM5	1.22e-04	4	158	2	16828831
Pubmed	HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs.	RBL2 CDC6	1.22e-04	4	158	2	15861133
Pubmed	Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner.	CFLAR PIK3CG	1.22e-04	4	158	2	21856935
Pubmed	SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species.	CAT TFB2M	1.22e-04	4	158	2	38047459
Pubmed	PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.	PDS5B PDS5A	1.22e-04	4	158	2	32285610
Pubmed	LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.	CGAS LRRK2	1.22e-04	4	158	2	32057291
Pubmed	The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.	RASGRF2 VAV2	1.22e-04	4	158	2	20011522
Pubmed	Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.	PDS5B PDS5A	1.22e-04	4	158	2	29217591
Pubmed	Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.	JAK3 PIK3CG	1.22e-04	4	158	2	19531027
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	NTMT1 CAT FAM53C LIG1 EAF1	1.27e-04	106	158	5	31024071
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PEX1 FARSB ARHGEF18 ALS2 THOC2 TRIM5 EML5 COQ8A NFX1 CDK5RAP2 EIF2AK4 TYW1 TFB2M ZNF726 STAG2	1.34e-04	1084	158	15	11544199
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	NOC2L BCLAF1 POLR2H ELAC2 CHCHD3 SULT1C3 DLG2 ZNF726 TBCD	1.36e-04	419	158	9	28700943
Pubmed	Tagging genes with cassette-exchange sites.	KLF8 SMG5 DYSF ECT2 BIRC6 PPIL1 ZNF726 MNT	1.57e-04	335	158	8	15741177
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NOC2L RBL2 FARSB SMG5 ECT2 CYFIP2 IARS2 PDS5A ZFR MNT STAG2 ZMYM3 ARMC6	1.57e-04	857	158	13	25609649
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	METTL3 IMPDH2 NOC2L POLR2H FARSB ECT2 KIF20B CYFIP2 HARS2 EIF1AX NFX1 PDS5A EIF3A TFB2M CTNND2 CROCC STAG2 ZMYM3	1.66e-04	1497	158	18	31527615
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	IMPDH2 POLR2H FARSB THOC2 BIRC6 GFPT1 LIG1 FBXO22 ZFR EIF3A	1.76e-04	534	158	10	35032548
Pubmed	Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.	LRRK2 GFPT1 IARS2 EIF3A	1.86e-04	62	158	4	26508657
Pubmed	Functional coherence of the human Y chromosome.	USP9Y EIF1AY EIF1AX	1.97e-04	25	158	3	9381176
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF2 ARHGEF18 ALS2 ECT2 ARHGEF40 VAV2	1.52e-06	66	98	6	722
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	KLF8 ZNF234 ZNF658 ZNF460 ZNF862 ZNF226 ZNF230 ZNF550 ZNF732 ZNF589 ZNF84 ZNF319 ZNF418 ZNF726	3.18e-05	718	98	14	28
GeneFamily	Aminoacyl tRNA synthetases, Class II	GARS1 FARSB HARS2	1.40e-04	19	98	3	132
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM21 TRIM39 TRIM5 TRIM45 TRIM44	1.66e-04	95	98	5	59
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	BCLAF1 USP37 THOC2 BIRC6 GCC2 PDS5A TRIM44 STAG2	4.61e-07	193	158	8	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LRRK2 CYFIP2 ITPKB TBC1D8 JAK3 TMTC1 PLCB1 VAV2	4.61e-07	193	158	8	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	Influenza-Influenza_Severe-Myeloid-cDC\|Influenza_Severe / Disease, condition lineage and cell class	NUDT19 KLF8 IMPDH2 RYR3 GCAT RAD54B KLHL23 SORBS3	6.03e-07	200	158	8	b8415a68ad6f4fea562236a1b0da0dc376d874fb
ToppCell	Influenza_Severe-cDC\|Influenza_Severe / Disease group and Cell class	NUDT19 REXO5 RYR3 ADRA2A RAD54B KLHL23 SORBS3	2.19e-06	166	158	7	b40bdf0f7f381e25be61188e9f6c294d25a8b824
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCLAF1 BIRC6 SLF2 GCC2 PDS5A EIF3A STAG2	4.32e-06	184	158	7	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LRRK2 ARHGEF18 CYFIP2 TBC1D8 JAK3 TMTC1 PLCB1	5.16e-06	189	158	7	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM94 TRIM39 JAK3 AP4E1 EFNA1 FBXO22 ZNF319	5.16e-06	189	158	7	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LRRK2 ARHGEF18 CYFIP2 TBC1D8 JAK3 TMTC1 PLCB1	5.34e-06	190	158	7	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1C DYSF ITPKB TMTC1 SCUBE1 PLCB1 TBCD	6.33e-06	195	158	7	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	droplet-Lung-nan-18m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CGAS TBC1D8 LIG1 EML5 RAD54B CDC6	3.04e-05	168	158	6	96f7411474edd673b8d3ee6b8a8bb185c246daaf
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALE MBLAC2 ECT2 KIF20B RAD54B CDC6	3.83e-05	175	158	6	8958c5c30437d20a4abd70d7527990f7e2a68b93
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7\|TCGA-Prostate / Sample_Type by Project: Shred V9	NUDT19 METTL3 GARS1 FARSB CDC6 VAV2	4.76e-05	182	158	6	af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPMT RYR3 CYFIP2 PTPN4 TMTC1 ZNF319	5.21e-05	185	158	6	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	REXO5 ECT2 KIF20B LIG1 CDK5RAP2 CDC6	5.53e-05	187	158	6	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	droplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CGAS USP37 LIG1 GCC2 KLHL23 PPIL1	5.53e-05	187	158	6	14c239af77116d28d511dea754b6150d20488080
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TPMT ABAT NTMT1 ZNF226 CFLAR PTPN4	5.87e-05	189	158	6	160963355256f7c0f2138da80c90de478f5a9fe8
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C PPP1R3A CKMT2 TMTC1 PLCB1 CTNND2	6.04e-05	190	158	6	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	facs-Pancreas\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 SCGN IDS CYFIP2 EML5 CTNND2	6.22e-05	191	158	6	d48e5f67d384226add7d7fb2a124954136e09a82
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C RASGRF2 ITPKB TBC1D8 TMTC1 PLCB1	6.40e-05	192	158	6	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast\|World / Lineage, cell class and subclass	RYR3 TESMIN GCAT KLHL23 PPIL1 DNAJC12	6.78e-05	194	158	6	f054d78429364622d402ce1d9bf6ad13a1a1bf7e
ToppCell	Adult-Immune-T_lymphocyte-D231\|Adult / Lineage, Cell type, age group and donor	RASGRF2 CYFIP2 ITPKB JAK3 PLCB1 IL26	6.78e-05	194	158	6	5c1dca33f382f37a7deb23e573578343c3b54986
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CGAS ECT2 KIF20B LIG1 TESMIN RAD54B	6.98e-05	195	158	6	c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	RASGRF2 RBL2 USP9Y CYFIP2 ITPKB GCC2	6.98e-05	195	158	6	4bdedd924564a260841a9153604026b57487c83d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KIF20B LIG1 ZNF732 RAD54B CDC6 ZNF726	6.98e-05	195	158	6	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	control-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	EFL1 DHX58 RBL2 IDS JAK3 ZNF550	6.98e-05	195	158	6	66959ae839eb60a573da06bdd227090ebb5bb9ed
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KIF20B LIG1 ZNF732 RAD54B CDC6 ZNF726	6.98e-05	195	158	6	56d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KIF20B LIG1 ZNF732 RAD54B CDC6 ZNF726	7.18e-05	196	158	6	df366d76ea55f49e349d622effa57c1535df8400
Computational	Genes in the cancer module 563.	GAD2 ABAT SNPH	2.82e-04	15	95	3	MODULE_563
Computational	Genes in the cancer module 110.	GARS1 LIG1 HARS2	3.45e-04	16	95	3	MODULE_110
Computational	Genes in the cancer module 35.	GARS1 LIG1 HARS2	3.45e-04	16	95	3	MODULE_35
Drug	Etilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; MCF7; HT_HG-U133A	DYNC2H1 VPS33A GSDMB PEX1 DYSF ITPKB CFLAR RAD54B NFX1 ZMYM3	1.23e-06	197	158	10	7350_DN
Drug	pyridoxal	GAD2 ABAT IMPDH2 CAT GFPT1 GCAT PDXP PLCB1	4.73e-06	135	158	8	CID000001050
Drug	AH6809; Up 200; 1uM; PC3; HT_HG-U133A	PDS5B METTL3 PEX1 SMG5 DYSF SLF2 PLCB1 KDM4A VAV2	1.09e-05	199	158	9	7075_UP
Drug	Gibberellic acid [77-06-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A	DYNC2H1 VPS33A GSDMB IDS DYSF CYFIP2 CFLAR SLF2 SORBS3	1.09e-05	199	158	9	7330_DN
Disease	uveal melanoma (implicated_via_orthology)	EIF1AY EIF1AX	2.64e-05	2	152	2	DOID:6039 (implicated_via_orthology)
Disease	Nasal Type Extranodal NK/T-Cell Lymphoma	CFLAR JAK3	7.88e-05	3	152	2	C0392788
Disease	Lymphoma, Extranodal NK-T-Cell	CFLAR JAK3	7.88e-05	3	152	2	C1955906
Disease	Abnormality of head or neck	TMEM94 STAG2	2.61e-04	5	152	2	C4021817
Disease	Involutional paraphrenia	CACNA1C GAD2 CAT	2.84e-04	25	152	3	C1571983
Disease	Psychosis, Involutional	CACNA1C GAD2 CAT	2.84e-04	25	152	3	C1571984
Disease	Involutional Depression	CACNA1C GAD2 CAT	2.84e-04	25	152	3	C0011574
Disease	Hematopoetic Myelodysplasia	CFLAR PLCB1 STAG2	4.44e-04	29	152	3	C2713368
Disease	microcephaly (implicated_via_orthology)	KIF20B PPIL1 CDK5RAP2	5.96e-04	32	152	3	DOID:10907 (implicated_via_orthology)
Disease	sensory perception of sweet taste	CACNA1C ITGA11 ALS2 KDM4A	8.67e-04	82	152	4	GO_0050916
Disease	glucose metabolism decline measurement, cingulate cortex measurement	TBC1D8 TYW1	9.27e-04	9	152	2	EFO_0007738, EFO_0009392
Disease	2-hydroxyglutaric acid measurement	ARHGEF18 PLCB1	9.27e-04	9	152	2	EFO_0010446
Disease	cholate measurement	PLCB1 ERICH6	1.15e-03	10	152	2	EFO_0021509
Disease	primary immunodeficiency disease (is_implicated_in)	IFIH1 LIG1 PIK3CG	1.33e-03	42	152	3	DOID:612 (is_implicated_in)
Disease	Major Depressive Disorder	CACNA1C GAD2 CAT PLCB1 DLG2 CTNND2	1.67e-03	243	152	6	C1269683
Disease	survival time, lung adenocarcinoma	UBAC1 DLG2	1.68e-03	12	152	2	EFO_0000571, EFO_0000714
Disease	Generalized seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0234533
Disease	Clonic Seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0234535
Disease	Convulsive Seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0751494
Disease	Seizures, Sensory	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0751496
Disease	Non-epileptic convulsion	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0751056
Disease	Atonic Absence Seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0751123
Disease	Complex partial seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0149958
Disease	Single Seizure	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0751110
Disease	Nonepileptic Seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C3495874
Disease	Visual seizure	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0270824
Disease	Epileptic drop attack	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0270846
Disease	Vertiginous seizure	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0422855
Disease	Gustatory seizure	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0422854
Disease	Seizures, Somatosensory	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0422850
Disease	Olfactory seizure	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0422853
Disease	Seizures, Auditory	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0422852
Disease	Generalized Absence Seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C4505436
Disease	Jacksonian Seizure	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C0022333
Disease	Epileptic Seizures	GAD2 ABAT CAT TBCD	1.88e-03	101	152	4	C4317109
Disease	Absence Seizures	GAD2 ABAT CAT TBCD	1.94e-03	102	152	4	C4316903
Disease	Convulsions	GAD2 ABAT CAT TBCD	1.94e-03	102	152	4	C4048158
Disease	Tonic Seizures	GAD2 ABAT CAT TBCD	1.94e-03	102	152	4	C0270844
Disease	Seizures, Focal	GAD2 ABAT CAT TBCD	2.09e-03	104	152	4	C0751495
Disease	Myoclonic Seizures	GAD2 ABAT CAT TBCD	2.09e-03	104	152	4	C4317123
Disease	Tonic - clonic seizures	GAD2 ABAT CAT TBCD	2.09e-03	104	152	4	C0494475
Disease	Intellectual Disability	KLF8 GALE TMEM94 FARSB AP4E1 TFB2M STAG2 TBCD	2.29e-03	447	152	8	C3714756
Disease	non-alcoholic fatty liver disease, type 2 diabetes mellitus	SCGN SLF2 DLG2 VAV2	2.56e-03	110	152	4	EFO_0003095, MONDO_0005148
Disease	response to cisplatin, platinum measurement	DYSF ECT2 VAV2	2.60e-03	53	152	3	EFO_0010154, GO_0072718
Disease	spinal stenosis	ELMOD2 GFPT1	3.41e-03	17	152	2	EFO_0007490
Disease	response to antipsychotic drug	DYNC2H1 CDK5RAP2 TRIM44	3.70e-03	60	152	3	GO_0097332
Disease	Chronic myeloproliferative disorder	JAK3 CDC6	4.26e-03	19	152	2	C1292778
Disease	myelodysplastic syndrome (is_marker_for)	CFLAR PLCB1	4.71e-03	20	152	2	DOID:0050908 (is_marker_for)
Disease	Microcephaly	FARSB STAG2 TBCD	5.04e-03	67	152	3	C0025958
Disease	MYELODYSPLASTIC SYNDROME	CFLAR PLCB1 STAG2	5.04e-03	67	152	3	C3463824
Disease	common carotid intimal medial thickness	RYR3 KLHL23 CTNND2	5.04e-03	67	152	3	EFO_0004860

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACRDFVFRHKDSRGK	ALKBH2	191	Q6NS38
IKIRRLFHKLEGCVN	ERICH6	601	Q7L0X2
HLKDKGQDARERREC	ARHGEF18	281	Q6ZSZ5
GDCDLAAVILHVKRR	CCL28	56	Q9NRJ3
REKFHEKIKGLLLDC	ELMOD2	271	Q8IZ81
ICGRKKCLRHVFLFE	ARHGEF40	1281	Q8TER5
LHFSAARGKERCVRV	ASB7	51	Q9H672
ARGKERCVRVFLEHG	ASB7	56	Q9H672
AGRSIAHKCARFLAL	BIRC6	1396	Q9NR09
RKRLCENIAGHLKDA	CAT	456	P04040
RCSKLEGELHKRTEI	CCDC62	71	Q6P9F0
RKLDRFHPKELLECA	EIF2AK4	1146	Q9P2K8
ECLALHLGRKRKEAE	ALS2	876	Q96Q42
KAALRDLGCHVELRE	ARMC6	476	Q6NXE6
HLQRCLDDLKERFAK	EFL1	666	Q7Z2Z2
ADRFRCFHLVGEKRT	GSDMB	31	Q8TAX9
CAGDHRVAEALKRLR	AVPI1	61	Q5T686
LAEFKVRALECHPDK	DNAJC12	31	Q9UKB3
DHLLLRLKCDSAFRG	CGAS	191	Q8N884
KAQKRGLCTVHREAD	CFLAR	386	O15519
HLCFGDNKIKAEIRR	CTNND2	576	Q9UQB3
REEHCLRLGESFEKR	EAF1	11	Q96JC9
IHIKFRKALCDRDVG	AP4E1	206	Q9UPM8
HREKSKGDCTIRDLR	CDK5RAP2	426	Q96SN8
KNIKFDLLICDEGHR	RAD54B	421	Q9Y620
CAKDPVKERRAHARQ	PDS5B	946	Q9NTI5
CAKDPVKERRAHARQ	PDS5A	956	Q29RF7
LFNDCLEIARKRHKV	ECT2	696	Q9H8V3
GLEKCHRFGLRKDLA	JAK3	111	P52333
LDFVCHVRNKRAGKE	PTPN4	831	P29074
FIRAEDGLCREVVKH	RBL2	571	Q08999
LDDCTRHESKVRKGL	ACP7	296	Q6ZNF0
FISLEECRGHKRARK	FBXO22	111	Q8NEZ5
RCKYSHKDIVAEGLR	FASTK	396	Q14296
DKALQCGRHVDVFKL	GAD2	441	Q05329
AEDESAKLCKRRIEH	MAEA	91	Q7L5Y9
LHKFCLGRALEGLER	NUDT19	276	A8MXV4
RVRDVFEAKARHGFC	IMPDH2	126	P12268
AGKLHCLRFLVEEAA	ESPN	46	B1AK53
KLRDIARKHGCAFLV	ABAT	311	P80404
VECGFATIKDLRDHK	EDEM2	406	Q9BV94
SIEKEKFAERHCGIL	MUC19	996	Q7Z5P9
RLAACKRKEQEHGKD	ONECUT1	366	Q9UBC0
ERRLAIFKDLVGKCD	KIF20B	636	Q96Q89
CFDGVKRLCHIRGKL	EIF1AY	51	O14602
CSALERKKRLAEAFH	NFX1	951	Q12986
LDLKRRRIHQCDFAG	KLF8	266	O95600
CFRHKIPNLERAKGA	KDM4A	881	O75164
ISRGCEAFLRHKVAL	KDM4E	231	B2RXH2
VQKLGCKALHVLFER	LRRK2	176	Q5S007
FDFKHIGCKAKDIIR	LRRK2	1306	Q5S007
NRRAHLKECFETLKR	MNT	231	Q99583
KINIFHRDCKRSGRD	ITGA11	651	Q9UKX5
SIIDGIRLCKAHKYR	GCAT	161	O75600
HKKFGVCLIGVRRED	KCNT2	516	Q6UVM3
AGCFIHLLADARLKE	CYHR1	91	Q6ZMK1
KRLCHAERRKDFVSE	CYFIP2	141	Q96F07
VLSRVCRHKKDTFLG	NOC2L	316	Q9Y3T9
KASDADRPCRKLHFR	METTL3	286	Q86U44
ICSEEERAKAKHLAR	CHCHD3	111	Q9NX63
GFLLFKNRSCRILHK	OR12D3	221	Q9UGF7
NIEVKDLGCLRRDFH	PPP1R3A	476	Q16821
HIAALRKLKEQCGCR	GALE	251	Q14376
KSAGLEKFDLRRFLC	DYNC2H1	3231	Q8NCM8
RAAREKEALAKEHAG	CROCC	866	Q5TZA2
SVKKACERFLVRHLD	KLHL23	121	Q8NBE8
SFHLECLKRQKDRGG	CACNA1C	1981	Q13936
ELCVDLRKSHLAKEG	EIF3A	56	Q14152
HEDRCLRLKVTVSGK	EFNA1	136	P20827
KGDKKLRCDSADLRH	BCLAF1	681	Q9NYF8
KLIFRVCALHDCKRI	COL6A5	796	A8TX70
AIFRIKDDEIRDKCG	TMEM63B	131	Q5T3F8
DNFHKKCEREERLIL	GCC2	611	Q8IWJ2
GCKKIRFVEDFHSLR	IL26	101	Q9NPH9
KEGNRKERVCAEHLR	IFIH1	591	Q9BYX4
EAACARKFRDLLKGH	COQ8A	411	Q8NI60
CHRRSQDPFGDLLKK	DHX58	221	Q96C10
VIRNFLREHICGKKA	CDC6	181	Q99741
SRGSICLHDKDRKIL	MBLAC2	171	Q68D91
CLHDKDRKILFSGDV	MBLAC2	176	Q68D91
SVRFVAERGKHCILD	DLG2	761	Q15700
GKKRDRRCAIHDIRF	EML5	1771	Q05BV3
LCREGKNLLKHFRFR	IDS	431	P22304
IIKGLFVACRHSEAR	LIG1	426	P18858
CDLDARKTGVKRRHE	FAM53C	276	Q9NYF3
REILLRHCDVNKDGK	SCGN	246	O76038
QKARFKIRDAKCHLR	SCUBE1	486	Q8IWY4
LRGAHFCLKVFRAED	DYSF	376	O75923
DAHVERVDCKALRGK	PEX1	621	O43933
RFIAAGRLHCKIDKV	PSMD6	336	Q15008
LKICGHRRDADVFEL	LRRC72	36	A6NJI9
DAAELLGHREAVKCR	OTP	16	Q5XKR4
KRVFERFCRGLKEVE	CKMT2	281	P17540
HDIERFKAIKACLGR	TESMIN	331	Q9Y4I5
LTDQHLAEFLRRCKG	NTMT1	141	Q9BV86
KREAERLCKSFLGEH	SKOR1	156	P84550
KRRDLAHLAAEVEGK	TRIM39	236	Q9HCM9
AERVAKRKCPDHGLD	TRIM44	171	Q96DX7
KCVLQGEDLHRAREK	TRIM45	401	Q9H8W5
KILDLVISCFKRHGA	HARS2	76	P49590
EKCKRAQTLDRHAFL	SULT1C3	76	Q6IMI6
RCQKEVGKSFERHKL	SMG5	921	Q9UPR3
LGGLKDHIKEIQRCR	GFPT1	371	Q06210
EHLVDGKSPRLCRKF	RASGRF2	711	O14827
GRILKKHCESEQRCL	ITPKB	686	P27987
IKLAAALARCRIKHD	NSUN7	166	Q8NE18
VKNGECFRADHLLKA	GARS1	206	P41250
DGKLRVIHCDFFKLD	TFB2M	141	Q9H5Q4
FCRGDVVHFLLVKRD	VPS8	371	Q8N3P4
RERKVKTEFCLHDGP	IARS2	101	Q9NSE4
LCGALEKHVKCDIRE	SLF2	1116	Q8IX21
EKHVKCDIREDARLF	SLF2	1121	Q8IX21
CHRVEAQLALKEARK	SNPH	126	O15079
CRKRALVAIGTHDLD	FARSB	151	Q9NSD9
FAKLREACAHLRDPE	PDXP	156	Q96GD0
HDFRRAFKKILCRGD	ADRA2A	446	P08913
RCKIKEGAVRREDLF	AKR1E2	51	Q96JD6
FKDRHFTCSKIIGRR	ANKFN1	11	Q8N957
DCDRKFRVKIRGIDI	PIK3CG	356	P48736
KVDHCARHGEKLLLF	TRIM5	91	Q9C035
ECGKAFSIRKDLIRH	ZNF460	396	Q14592
RGEFLHLCRILSENK	THOC2	21	Q8NI27
CLAAFKRLEHKEVLV	TMTC1	371	Q8IUR5
VAFICKLHLKRGNFL	ELAC2	241	Q9BQ52
HAPKTCKNFAELARR	PPIL1	31	Q9Y3C6
EAVLEGHLRERKKCL	TMEM94	31	Q12767
EALHKRRNLLAAFCK	STAG2	856	Q8N3U4
AGLFCKLAALVRHRI	RYR3	2901	Q15413
EFGCLRKAFRHKFRL	REXO5	116	Q96IC2
FRLPRKEKLHAVVDC	TBC1D8	291	O95759
GHRFCKACIIKSIRD	TRAF6	86	Q9Y4K3
VELSFRKGEHICLIR	SORBS3	471	O60504
DPEGKKFDRVSRLHC	POLR2H	16	P52434
EKLRAVCLDHAKLGE	USP9Y	1056	O00507
GERLHLFCEKDGKAL	TRIM21	96	P19474
LSLVKDARCGRHAKA	PLCB1	66	Q9NQ66
KGFSRRADLKIHCRI	ZNF234	491	Q14588
SFKDGRLHGICLDKL	ZNF862	896	O60290
DKLKIIKRGHECDAF	ZNF84	96	P51523
ECGKTFVRKAALRVH	ZNF658	1026	Q5TYW1
ECGKGFSRRADLKIH	ZNF226	591	Q9NYT6
QKVILRRFEKCGHEN	ZNF726	96	A6NNF4
CIECGKAFKRRSHLL	ZNF550	401	Q7Z398
KGFDQSAELLRHKCL	ZNF319	406	Q9P2F9
DVARAKCLRVLKGHQ	WDR38	91	Q5JTN6
RRFAHLLVKKDICNS	USP37	386	Q86T82
EVRNDEGKVIRFHCK	ZFR	571	Q96KR1
CRECRKLFRGKSHLI	ZNF418	456	Q8TF45
KGFRCRAILQVHCKL	ZNF230	231	Q9UIE0
ALAQIFKHGKREDCL	TBCD	256	Q9BTW9
RELREFLDKCAGSKA	VPS33A	21	Q96AX1
EKIFAGKVLRLHICA	UBAC1	6	Q9BSL1
NCLLIAHRKFKIGGE	TYW1	651	Q9NV66
RTFLKVCHDKFGLRN	VAV2	76	P52735
RRYEKCGHENLELRK	ZNF732	101	B4DXR9
VCGRGFREKSELIKH	ZNF589	336	Q86UQ0
VRELRHSRTGCKFKF	TSPY26P	226	Q9H489
HAEIERLFGKICNIR	TPMT	201	P51580
AAFIKAFCRHKLIEL	ZYG11A	116	Q6WRX3
VLAAKERHCGELKRR	TPD52L2	66	O43399
CRQEKLLHEKLRFSG	ZMYM3	636	Q14202
ECGKTFVRKAALRVH	ZNF658B	786	Q4V348
CFDGVKRLCHIRGKL	EIF1AX	51	P47813