Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	ACTBL2 POTEJ	6.94e-05	11	23	2	GO:0098973
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	KRT71 ACTBL2 POTEJ	4.34e-04	130	23	3	GO:0005200
GeneOntologyMolecularFunction	protein transmembrane transporter activity	TIMM23 TIMM23B	4.71e-04	28	23	2	GO:0008320
GeneOntologyMolecularFunction	structural constituent of postsynapse	ACTBL2 POTEJ	6.16e-04	32	23	2	GO:0099186
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	TIMM23 TIMM23B	6.96e-04	34	23	2	GO:0022884
GeneOntologyMolecularFunction	protein transporter activity	TIMM23 TIMM23B	1.06e-03	42	23	2	GO:0140318
GeneOntologyMolecularFunction	structural constituent of synapse	ACTBL2 POTEJ	1.06e-03	42	23	2	GO:0098918
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring tensile strength	OTOL1 COL22A1	1.27e-03	46	23	2	GO:0030020
GeneOntologyMolecularFunction	structural molecule activity	KRT71 OTOL1 ACTBL2 COL22A1 POTEJ	3.01e-03	891	23	5	GO:0005198
GeneOntologyCellularComponent	migrasome	TIMM23 TIMM23B	4.15e-05	9	23	2	GO:0140494
GeneOntologyCellularComponent	TIM23 mitochondrial import inner membrane translocase complex	TIMM23 TIMM23B	1.38e-04	16	23	2	GO:0005744
GeneOntologyCellularComponent	H4/H2A histone acetyltransferase complex	ACTBL2 POTEJ	5.63e-04	32	23	2	GO:0043189
GeneOntologyCellularComponent	NuA4 histone acetyltransferase complex	ACTBL2 POTEJ	5.63e-04	32	23	2	GO:0035267
GeneOntologyCellularComponent	H4 histone acetyltransferase complex	ACTBL2 POTEJ	1.11e-03	45	23	2	GO:1902562
GeneOntologyCellularComponent	collagen-containing extracellular matrix	ADAMTS4 OTOL1 EYS COL22A1	2.47e-03	530	23	4	GO:0062023
GeneOntologyCellularComponent	mitochondrial intermembrane space	TIMM23 TIMM23B	4.19e-03	88	23	2	GO:0005758
GeneOntologyCellularComponent	collagen trimer	OTOL1 COL22A1	4.19e-03	88	23	2	GO:0005581
GeneOntologyCellularComponent	histone acetyltransferase complex	ACTBL2 POTEJ	4.76e-03	94	23	2	GO:0000123
GeneOntologyCellularComponent	extracellular matrix	ADAMTS4 OTOL1 EYS COL22A1	5.29e-03	656	23	4	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS4 OTOL1 EYS COL22A1	5.35e-03	658	23	4	GO:0030312
GeneOntologyCellularComponent	organelle envelope lumen	TIMM23 TIMM23B	5.58e-03	102	23	2	GO:0031970
GeneOntologyCellularComponent	protein acetyltransferase complex	ACTBL2 POTEJ	5.79e-03	104	23	2	GO:0031248
GeneOntologyCellularComponent	acetyltransferase complex	ACTBL2 POTEJ	6.35e-03	109	23	2	GO:1902493
GeneOntologyCellularComponent	inner mitochondrial membrane protein complex	TIMM23 TIMM23B	7.64e-03	120	23	2	GO:0098800
HumanPheno	Sparse body hair	KRT71 PROK2 WNT10A	1.69e-05	62	5	3	HP:0002231
MousePheno	abnormal coat appearance	KRT71 TIMM23 WNT10A TIMM23B DUSP7 TNKS2	1.40e-04	774	16	6	MP:0001510
MousePheno	abnormal coat/ hair morphology	KRT71 TIMM23 WNT10A TIMM23B DUSP7 TNKS2	2.41e-04	854	16	6	MP:0000367
MousePheno	alopecia	KRT71 TIMM23 TIMM23B	2.88e-04	116	16	3	MP:0000414
MousePheno	abnormal skin adnexa morphology	KRT71 TIMM23 WNT10A ACTG2 TIMM23B DUSP7 TNKS2	3.86e-04	1341	16	7	MP:0010678
Domain	Actin_CS	ACTG2 ACTBL2 POTEJ	7.86e-07	16	22	3	IPR004001
Domain	ACTINS_2	ACTG2 ACTBL2 POTEJ	9.54e-07	17	22	3	PS00432
Domain	Actin/actin-like_CS	ACTG2 ACTBL2 POTEJ	1.14e-06	18	22	3	IPR020902
Domain	ACTINS_ACT_LIKE	ACTG2 ACTBL2 POTEJ	1.36e-06	19	22	3	PS01132
Domain	Actin	ACTG2 ACTBL2 POTEJ	6.24e-06	31	22	3	IPR004000
Domain	Actin	ACTG2 ACTBL2 POTEJ	6.24e-06	31	22	3	PF00022
Domain	ACTIN	ACTG2 ACTBL2 POTEJ	6.24e-06	31	22	3	SM00268
Domain	ACTINS_1	ACTG2 ACTBL2	3.69e-05	8	22	2	PS00406
Domain	Laminin_G	EYS COL22A1	2.10e-03	58	22	2	IPR001791
Domain	Collagen	OTOL1 COL22A1	4.46e-03	85	22	2	PF01391
Domain	Collagen	OTOL1 COL22A1	4.46e-03	85	22	2	IPR008160
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	ACTG2 ACTBL2 POTEJ	1.14e-07	15	23	3	16824795
Pubmed	Effect of Tim23 knockdown in vivo on mitochondrial protein import and retrograde signaling to the UPRmt in muscle.	TIMM23 TIMM23B	4.18e-07	2	23	2	29949403
Pubmed	Hormonal regulation of mitochondrial Tim23 gene expression in the mouse mammary gland.	TIMM23 TIMM23B	4.18e-07	2	23	2	11165051
Pubmed	Mutant huntingtin does not cross the mitochondrial outer membrane.	TIMM23 TIMM23B	1.25e-06	3	23	2	32821928
Pubmed	Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes.	TIMM23 TIMM23B	1.25e-06	3	23	2	12437925
Pubmed	Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice.	TIMM23 TIMM23B	1.25e-06	3	23	2	31326434
Pubmed	Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease.	TIMM23 TIMM23B	1.25e-06	3	23	2	30405116
Pubmed	NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.	TIMM23 TIMM23B	1.25e-06	3	23	2	37044213
Pubmed	Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.	TIMM23 TIMM23B	2.51e-06	4	23	2	19111522
Pubmed	The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix.	TIMM23 TIMM23B	2.51e-06	4	23	2	10393182
Pubmed	A spastic paraplegia mouse model reveals REEP1-dependent ER shaping.	TIMM23 TIMM23B	6.26e-06	6	23	2	24051375
Pubmed	Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice.	TIMM23 TIMM23B	6.26e-06	6	23	2	15282315
Pubmed	Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology.	TIMM23 TIMM23B	8.77e-06	7	23	2	21984432
Pubmed	Role of Bax and Bak in mitochondrial morphogenesis.	TIMM23 TIMM23B	8.77e-06	7	23	2	17035996
Pubmed	Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.	TIMM23 TIMM23B	1.17e-05	8	23	2	15044455
Pubmed	The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice.	TIMM23 TIMM23B	1.50e-05	9	23	2	19752021
Pubmed	Mitocytosis, a migrasome-mediated mitochondrial quality-control process.	TIMM23 TIMM23B	1.88e-05	10	23	2	34048705
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT71 ACTG2 PSMD1 ACTBL2 UGGT1 AHCYL2 POTEJ	2.83e-05	1442	23	7	35575683
Pubmed	Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.	TIMM23 TIMM23B	3.25e-05	13	23	2	10920231
Pubmed	Genetic and structural characterization of the human mitochondrial inner membrane translocase.	TIMM23 TIMM23B	3.79e-05	14	23	2	10339406
Pubmed	USP25 regulates Wnt signaling by controlling the stability of tankyrases.	UGGT1 TNKS2	4.99e-05	16	23	2	28619731
Pubmed	Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.	TIMM23 TIMM23B	5.66e-05	17	23	2	11709546
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	KRT71 ACTG2 PSMD1 ACTBL2 AHCYL2 POTEJ	8.15e-05	1153	23	6	29845934
Pubmed	Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.	TIMM23 TIMM23B	9.59e-05	22	23	2	11431695
Pubmed	The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.	TIMM23 TIMM23B	2.90e-04	38	23	2	33913477
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	TIMM23 ACTG2 PSMD1 TIMM23B UGGT1	3.39e-04	952	23	5	38569033
Pubmed	A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.	ACTG2 ACTBL2	3.72e-04	43	23	2	20876399
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PASK PSMD1 OTOL1 UGGT1 DUSP7	3.77e-04	974	23	5	28675297
Pubmed	New insights on the functional role of URG7 in the cellular response to ER stress.	PSMD1 UGGT1	4.44e-04	47	23	2	29704455
Interaction	TIMM17B interactions	TIMM23 TIMM23B DUSP7	2.17e-05	48	23	3	int:TIMM17B
Interaction	ACTG2 interactions	ACTG2 ACTBL2 POTEJ	2.31e-05	49	23	3	int:ACTG2
Interaction	POTEJ interactions	ACTG2 ACTBL2 POTEJ	2.77e-05	52	23	3	int:POTEJ
Interaction	PFN3 interactions	ACTBL2 POTEJ	5.58e-05	10	23	2	int:PFN3
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	TIMM23 TIMM23B	3.99e-03	188	23	2	chr10q11
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	PASK PSMD1	5.70e-03	226	23	2	chr2q37
GeneFamily	Ankyrin repeat domain containing	POTEJ TNKS2	1.67e-02	242	15	2	403
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A5 ACTBL2 COL22A1	5.54e-05	145	23	3	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	KLK8 WNT10A COL22A1	7.98e-05	164	23	3	08c725548e751f815b4df778607270498204b353
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS4 ACTG2 TMEM200C	1.03e-04	179	23	3	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.25e-04	191	23	3	2f733d510a4862565a817f59829d8387d7ea26d9
ToppCell	droplet-Mammary_Gland-nan-18m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.31e-04	194	23	3	a516839871c4e9683093a1c07b72c682f9ecbb3d
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.33e-04	195	23	3	717e6a66bad50e711442d71360b540789646b334
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.33e-04	195	23	3	10774b5ce17d4edd23dbf4709b11cc87cc2b87be
ToppCell	(5)_Fibroblast-J_(Lipofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	KLK8 ADAMTS4 TMEM200C	1.35e-04	196	23	3	afa29399decd17fda7d63add5039ff778627ccc2
ToppCell	ILEUM-non-inflamed-(8)_Pericytes\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ADAMTS4 ACTG2 TMEM200C	1.35e-04	196	23	3	b98fe1519e420d8b03c66e164bf4544f3dbb2e44
ToppCell	droplet-Mammary_Gland-nan-18m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.35e-04	196	23	3	558324d7779463fd5cd438aee7d0f86be7366d3f
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.37e-04	197	23	3	5bf5187fcba4ccc3f83bc9e884e40ff344a3d109
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.37e-04	197	23	3	87d09f53b84af482116d3e2076eab1a9e555a2a6
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.41e-04	199	23	3	1b74f6fbf2628f335ba5eb49b679d2f72068bbbe
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A ACTG2 DUSP7	1.41e-04	199	23	3	a660f7373fca03929234cbd936735f97883fb689
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS4 ACTG2 DUSP7	1.44e-04	200	23	3	a372ef3f9e6ff6e3c3376d6e10182977c5067788
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ACTG2 TIMM23B DUSP7	1.44e-04	200	23	3	410b1a31de21c57d87ca2104f61cf4a7d4dd2f30
Disease	autosomal dominant nonsyndromic deafness 20 (implicated_via_orthology)	ACTG2 ACTBL2	1.48e-05	8	22	2	DOID:0110550 (implicated_via_orthology)
Disease	Moyamoya disease (implicated_via_orthology)	ACTG2 ACTBL2	1.48e-05	8	22	2	DOID:13099 (implicated_via_orthology)
Disease	thoracic aortic aneurysm (implicated_via_orthology)	ACTG2 ACTBL2	1.48e-05	8	22	2	DOID:14004 (implicated_via_orthology)
Disease	Baraitser-Winter syndrome 1 (implicated_via_orthology)	ACTG2 ACTBL2	1.48e-05	8	22	2	DOID:0081112 (implicated_via_orthology)
Disease	patent ductus arteriosus (implicated_via_orthology)	ACTG2 ACTBL2	2.38e-05	10	22	2	DOID:13832 (implicated_via_orthology)
Disease	intestinal atresia (implicated_via_orthology)	ACTG2 ACTBL2	2.38e-05	10	22	2	DOID:10486 (implicated_via_orthology)
Disease	muscular atrophy (biomarker_via_orthology)	TIMM23 TIMM23B	2.13e-04	29	22	2	DOID:767 (biomarker_via_orthology)
Disease	response to antipsychotic drug	EYS COL22A1	9.15e-04	60	22	2	GO_0097332
Disease	language measurement	ATP13A5 COL22A1	4.46e-03	134	22	2	EFO_0007797
Disease	skin aging measurement	WNT10A SPIRE2	7.97e-03	181	22	2	EFO_0008006

Protein segments in the cluster

Peptide	Gene	Start	Entry
GMCGDGANDCGALKA	ATP13A5	846	Q4VNC0
VDNGSGMCKAGFGGD	ACTBL2	11	Q562R1
CDNGSGLCKAGFAGD	ACTG2	11	P63267
EDGGSDAGMCGLCQK	PASK	556	Q96RG2
AKGGSNVGDCDGTAC	EYS	2886	Q5T1H1
VGSGKDQCCSGKGDM	OSBP	336	P22059
TGACDKDSQCGGGMC	PROK2	31	Q9HC23
KFDKCMVCGGDGSGC	ADAMTS4	671	O75173
MVCGGDGSGCSKQSG	ADAMTS4	676	O75173
TGAGAATGAGAMPCK	DUSP7	41	Q16829
CSCPAGEKGEMGVAG	COL22A1	476	Q8NFW1
MVCAGSSKGADTCQG	KLK8	196	O60259
GEMGDKGCCGDSGER	OTOL1	236	A6NHN0
GEVGKGCCAALKAMG	AHCYL2	401	Q96HN2
CGGSGDAFGAAAMLA	TMEM200C	266	A6NKL6
GSGMCKAGFAGDDAP	POTEJ	676	P0CG39
GAAMALGICCAGTGN	PSMD1	651	Q99460
MARAGSCGGAAAGAG	SPIRE2	1	Q8WWL2
GGCCMTGAAFGAMNG	TIMM23B	81	Q5SRD1
MSGRRCAGGGAACAS	TNKS2	1	Q9H2K2
LCNKSSAGSDGCGSM	WNT10A	361	Q9GZT5
SAGSDGCGSMCCGRG	WNT10A	366	Q9GZT5
GGCCMTGAAFGAMNG	TIMM23	81	O14925
MGCKGDASGACAAGA	UGGT1	1	Q9NYU2
TCKSGAAAKGGFSGC	KRT71	6	Q3SY84