Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphospholipase binding

TESPA1 KAT5

5.13e-0432212GO:0043274
GeneOntologyMolecularFunctionactinin binding

XIRP2 LMO7

9.27e-0443212GO:0042805
MousePhenochromosomal instability

UIMC1 CDK12 LRGUK

1.96e-04109153MP:0008866
MousePhenodecreased tumor-free survival time

APC UIMC1

2.23e-0421152MP:0014237
MousePhenoabnormal tumor-free survival time

APC UIMC1

2.23e-0421152MP:0014235
MousePhenoabnormal chromosome stability

UIMC1 CDK12 LRGUK

2.30e-04115153MP:0010094
PathwayBIOCARTA_PITX2_PATHWAY

APC KAT5

9.55e-0515142MM1439
PathwayBIOCARTA_PITX2_PATHWAY

APC KAT5

1.09e-0416142M8516
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

APC USP8 KAT5

4.59e-04158143MM14791
PathwayPID_ATM_PATHWAY

UIMC1 KAT5

5.05e-0434142M84
Pubmed

Proteomic identification of overexpressed adenomatous polyposis coli and cyclin B3 during endoderm differentiation from human embryonic stem cells.

APC CCNB3

3.47e-07221221404461
Pubmed

Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.

UIMC1 KAT5

3.47e-06521226446986
Pubmed

EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.

APC KAT5

1.56e-051021223001180
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

APC LMO7 USP8

3.13e-0510221315778465
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

APC UIMC1 LMO7 CDK12

5.94e-0536121430344098
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

APC XIRP2

6.55e-052021221689717
Pubmed

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

APC LMO7 USP8

1.99e-0419021315161933
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

APC UIMC1 GPATCH1

2.85e-0421521335973513
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PRUNE2 LMO7 CDK12

3.26e-0422521312168954
GeneFamilyLIM domain containing

XIRP2 LMO7

9.29e-04591421218
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

APC CDK12 USP8 PARP4

1.60e-0618621403db813598b67b1e08f759758a1c2023396921fa
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

TESPA1 FAM117A

7.18e-044992GAVISH_3CA_MALIGNANT_METAPROGRAM_37_HEMATO_RELATED_2
ComputationalGenes in the cancer module 331.

APC USP8

1.68e-037592MODULE_331
Diseaseserum albumin measurement

SCAF1 CDK12 ARHGEF19 FAM117A

4.89e-04592194EFO_0004535
DiseaseAdenocarcinoma of large intestine

APC CDK12

1.73e-0396192C1319315
Diseasespine bone mineral density

GPATCH1 KAT5

2.64e-03119192EFO_0007701
DiseaseColonic Neoplasms

APC PARP4

4.26e-03152192C0009375
DiseaseMalignant tumor of colon

APC PARP4

4.65e-03159192C0007102
Diseasenon-alcoholic fatty liver disease

GID4 ARHGEF19

6.04e-03182192EFO_0003095
Diseaseatopic asthma

CDK12 TESPA1

7.18e-03199192EFO_0010638
DiseaseColorectal Carcinoma

APC CCNB3 LMO7

9.78e-03702193C0009402
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

PRUNE2 USP8

1.02e-02239192EFO_0010934
Diseasephysical activity measurement

APC CIR1

1.07e-02245192EFO_0008002

Protein segments in the cluster

PeptideGeneStartEntry
PKEWHKASARARSKT

FAM228A

116

Q86W67
RSPHRKWSDSSKQDD

CDK12

221

Q9NYV4
TSEKFSWPAKERSRK

ANKRD30B

346

Q9BXX2
KRSASWGSTDHRKEI

FAM117A

141

Q9C073
RHSALWEKPSTEKET

CCNB3

876

Q8WWL7
RRASHGSEKKSAWRK

ARHGEF19

126

Q8IW93
DSKCLHFTPKDWSKR

KAT5

496

Q92993
DKSRKPSRWDTSKHE

GPATCH1

676

Q9BRR8
PSRWDTSKHEKKEDS

GPATCH1

681

Q9BRR8
KKPDKHEDNRRSWAS

LMO7

331

Q8WWI1
WAKLSAKKTPAERDS

LRGUK

651

Q96M69
ASSEWPELRLSKRKH

PARP4

1226

Q9UKK3
SKKHPFLTRKWDADE

GID4

181

Q8IVV7
RRKKDSVESHPTWVD

FAM102A

306

Q5T9C2
WKEHKPSSIDRRASD

PRUNE2

686

Q8WUY3
TWKREHSKHSSSLPR

APC

2546

P25054
PRFLKHESSREDSKW

CIR1

336

Q86X95
KESSHRWKESKQPDA

XIRP2

1701

A4UGR9
PASPWDSKKHRSRDR

SCAF1

546

Q9H7N4
HSDWKRRSKSKESMP

ZNF514

71

Q96K75
TETHPAKDETFWKRK

TESPA1

421

A2RU30
EAHLPDDSKDTWKKR

USP8

236

P40818
RQESRASDWHSKTKD

UIMC1

361

Q96RL1