Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor binding	SHANK1 MAGI2 GNAT3 PPP2CA GNAI1 GNAL ITCH DNAJA1	7.58e-07	337	45	8	GO:0001664
GeneOntologyMolecularFunction	G-protein beta/gamma-subunit complex binding	GNAT3 GNAI1 GNAL	2.38e-05	25	45	3	GO:0031683
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	CUL4A AREL1 ITCH WWP1 WWP2 RNF170	1.77e-04	372	45	6	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	CUL4A AREL1 ITCH WWP1 WWP2 RNF170	2.55e-04	398	45	6	GO:0061659
GeneOntologyMolecularFunction	structural constituent of postsynaptic density	SHANK1 MAGI2	2.70e-04	11	45	2	GO:0098919
GeneOntologyMolecularFunction	structural constituent of postsynaptic specialization	SHANK1 MAGI2	3.81e-04	13	45	2	GO:0098879
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	CUL4A AREL1 ITCH WWP1 WWP2 RNF170	6.37e-04	473	45	6	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	CUL4A AREL1 ITCH WWP1 WWP2 RNF170	9.62e-04	512	45	6	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	CUL4A AREL1 ITCH WWP1 WWP2 RNF170	1.17e-03	532	45	6	GO:0016755
GeneOntologyMolecularFunction	adrenergic receptor binding	MAGI2 PPP2CA	1.33e-03	24	45	2	GO:0031690
GeneOntologyMolecularFunction	acyltransferase activity	CUL4A AREL1 ITCH PLA2G4E WWP1 WWP2 RNF170	1.62e-03	775	45	7	GO:0016746
GeneOntologyMolecularFunction	structural constituent of postsynapse	SHANK1 MAGI2	2.36e-03	32	45	2	GO:0099186
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	NSD1 DNAJA1 BAZ2A BHLHE40 WWP2	2.38e-03	417	45	5	GO:0061629
GeneOntologyCellularComponent	heterotrimeric G-protein complex	GNAT3 GNAI1 GNAL	6.21e-05	35	46	3	GO:0005834
GeneOntologyCellularComponent	GTPase complex	GNAT3 GNAI1 GNAL	1.00e-04	41	46	3	GO:1905360
GeneOntologyCellularComponent	cytoplasmic side of membrane	GNAT3 GNAI1 GNAL DNAJA1 RYR3	1.47e-04	230	46	5	GO:0098562
GeneOntologyCellularComponent	extrinsic component of membrane	MAGI2 GNAT3 GNAI1 GNAL TRIO	1.47e-04	230	46	5	GO:0019898
GeneOntologyCellularComponent	extrinsic component of plasma membrane	MAGI2 GNAT3 GNAI1 GNAL	2.33e-04	137	46	4	GO:0019897
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	GNAT3 GNAI1 GNAL	2.55e-04	56	46	3	GO:0031234
GeneOntologyCellularComponent	FAR/SIN/STRIPAK complex	PPP2CA PPP2CB	6.31e-04	17	46	2	GO:0090443
GeneOntologyCellularComponent	protein phosphatase type 2A complex	PPP2CA PPP2CB	7.09e-04	18	46	2	GO:0000159
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	GNAT3 GNAI1 GNAL RYR3	7.25e-04	185	46	4	GO:0009898
MousePheno	abnormal fasting circulating glucose level	CUL4A AREL1 ITCH BAZ2A BHLHE40 WWP1 IPO11 MSI2	2.16e-05	474	36	8	MP:0013277
Domain	HECT	AREL1 ITCH WWP1 WWP2	4.95e-07	27	45	4	PF00632
Domain	HECTc	AREL1 ITCH WWP1 WWP2	4.95e-07	27	45	4	SM00119
Domain	HECT_dom	AREL1 ITCH WWP1 WWP2	4.95e-07	27	45	4	IPR000569
Domain	HECT	AREL1 ITCH WWP1 WWP2	4.95e-07	27	45	4	PS50237
Domain	WW	MAGI2 ITCH WWP1 WWP2	4.86e-06	47	45	4	PF00397
Domain	WW	MAGI2 ITCH WWP1 WWP2	5.29e-06	48	45	4	SM00456
Domain	E3_ub_ligase_SMURF1	WWP1 WWP2	5.68e-06	2	45	2	IPR024928
Domain	WW_DOMAIN_2	MAGI2 ITCH WWP1 WWP2	6.76e-06	51	45	4	PS50020
Domain	WW_DOMAIN_1	MAGI2 ITCH WWP1 WWP2	6.76e-06	51	45	4	PS01159
Domain	G-alpha	GNAT3 GNAI1 GNAL	7.16e-06	16	45	3	PF00503
Domain	GproteinA_insert	GNAT3 GNAI1 GNAL	7.16e-06	16	45	3	IPR011025
Domain	-	GNAT3 GNAI1 GNAL	7.16e-06	16	45	3	1.10.400.10
Domain	G_alpha	GNAT3 GNAI1 GNAL	7.16e-06	16	45	3	SM00275
Domain	WW_dom	MAGI2 ITCH WWP1 WWP2	7.31e-06	52	45	4	IPR001202
Domain	Gprotein_alpha_su	GNAT3 GNAI1 GNAL	8.68e-06	17	45	3	IPR001019
Domain	Gprotein_alpha_I	GNAT3 GNAI1	1.57e-04	8	45	2	IPR001408
Domain	TBC	TBC1D3H TBC1D3G TBC1D3B	2.23e-04	49	45	3	SM00164
Domain	C2	ITCH PLA2G4E WWP1 WWP2	2.76e-04	131	45	4	PF00168
Domain	RabGAP-TBC	TBC1D3H TBC1D3G TBC1D3B	2.81e-04	53	45	3	PF00566
Domain	TBC_RABGAP	TBC1D3H TBC1D3G TBC1D3B	3.14e-04	55	45	3	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D3H TBC1D3G TBC1D3B	3.14e-04	55	45	3	IPR000195
Domain	C2	ITCH PLA2G4E WWP1 WWP2	3.27e-04	137	45	4	SM00239
Domain	C2	ITCH PLA2G4E WWP1 WWP2	3.75e-04	142	45	4	PS50004
Domain	Ser/Thr-sp_prot-phosphatase	PPP2CA PPP2CB	4.35e-04	13	45	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP2CA PPP2CB	4.35e-04	13	45	2	PS00125
Domain	PP2Ac	PPP2CA PPP2CB	4.35e-04	13	45	2	SM00156
Domain	-	ITCH PLA2G4E WWP1 WWP2	4.38e-04	148	45	4	2.60.40.150
Domain	C2_dom	ITCH PLA2G4E WWP1 WWP2	6.45e-04	164	45	4	IPR000008
Domain	ARM-type_fold	RIPOR1 CLASP1 LYST RYR3 IPO11	1.29e-03	339	45	5	IPR016024
Domain	Calcineurin-like_PHP_ApaH	PPP2CA PPP2CB	2.06e-03	28	45	2	IPR004843
Domain	Metallophos	PPP2CA PPP2CB	2.06e-03	28	45	2	PF00149
Domain	Metallo-depent_PP-like	PPP2CA PPP2CB	2.37e-03	30	45	2	IPR029052
Domain	-	PPP2CA PPP2CB	2.37e-03	30	45	2	3.60.21.10
Domain	HEAT	CLASP1 IPO11	8.61e-03	58	45	2	IPR000357
Pathway	REACTOME_OPIOID_SIGNALLING	GNAT3 PPP2CA PPP2CB GNAI1 GNAL	6.98e-07	71	34	5	MM14491
Pathway	REACTOME_OPIOID_SIGNALLING	GNAT3 PPP2CA PPP2CB GNAI1 GNAL	2.28e-06	90	34	5	M6467
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	GNAT3 GNAI1 GNAL	4.58e-06	14	34	3	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	GNAT3 GNAI1 GNAL	4.58e-06	14	34	3	M750
Pathway	PID_TGFBR_PATHWAY	PPP2CA PPP2CB ITCH WWP1	8.19e-06	54	34	4	M286
Pathway	KEGG_LONG_TERM_DEPRESSION	PPP2CA PPP2CB GNAI1 PLA2G4E	2.31e-05	70	34	4	M8232
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	GNAT3 PPP2CA PPP2CB GNAI1 RGS11 GNAL	5.85e-05	289	34	6	MM15057
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	GNAT3 PPP2CA PPP2CB GNAI1 RGS11 GNAL	9.25e-05	314	34	6	M600
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	GNAT3 GNAI1 GNAL	1.10e-04	39	34	3	MM14496
Pathway	REACTOME_SIGNALING_BY_GPCR	GNAT3 PPP2CA PPP2CB GNAI1 RGS11 GNAL TRIO HCRTR2	1.17e-04	646	34	8	MM14962
Pathway	REACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS	PPP2CA PPP2CB	1.18e-04	7	34	2	M26992
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNAT3 GNAI1 GNAL	1.48e-04	43	34	3	M954
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNAT3 GNAI1 GNAL	1.59e-04	44	34	3	MM15709
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ITCH WWP1	2.01e-04	9	34	2	M26930
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ITCH WWP1	2.01e-04	9	34	2	MM14535
Pathway	REACTOME_SIGNALING_BY_GPCR	GNAT3 PPP2CA PPP2CB GNAI1 RGS11 GNAL TRIO HCRTR2	2.08e-04	702	34	8	M746
Pathway	REACTOME_MASTL_FACILITATES_MITOTIC_PROGRESSION	PPP2CA PPP2CB	2.51e-04	10	34	2	M27176
Pathway	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	PPP2CA PPP2CB	2.51e-04	10	34	2	MM14509
Pathway	KEGG_TIGHT_JUNCTION	MAGI2 PPP2CA PPP2CB GNAI1	2.74e-04	132	34	4	M11355
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	GNAT3 GNAI1 GNAL	2.92e-04	54	34	3	M26911
Pathway	KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	CUL4A ITCH WWP1 WWP2	2.99e-04	135	34	4	M15247
Pathway	REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	PPP2CA PPP2CB	3.67e-04	12	34	2	M27950
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNAT3 GNAI1 GNAL	3.99e-04	60	34	3	M976
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNAT3 GNAI1 GNAL	3.99e-04	60	34	3	MM15708
Pathway	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	PPP2CA PPP2CB	4.33e-04	13	34	2	M1015
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	GNAI1 RYR3	4.33e-04	13	34	2	M39589
Pathway	REACTOME_ERKS_ARE_INACTIVATED	PPP2CA PPP2CB	4.33e-04	13	34	2	MM14811
Pathway	WP_DOPAMINE_METABOLISM	PPP2CA PPP2CB	4.33e-04	13	34	2	M39622
Pathway	REACTOME_ERKS_ARE_INACTIVATED	PPP2CA PPP2CB	4.33e-04	13	34	2	M8410
Pathway	REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS	PPP2CA PPP2CB	5.81e-04	15	34	2	M27407
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE	PPP2CA PPP2CB	6.63e-04	16	34	2	M47870
Pathway	REACTOME_DARPP_32_EVENTS	PPP2CA PPP2CB	6.63e-04	16	34	2	MM14699
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	PPP2CA PPP2CB	6.63e-04	16	34	2	MM14541
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	PPP2CA PPP2CB	6.63e-04	16	34	2	M514
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2CA PPP2CB	7.51e-04	17	34	2	MM15096
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2CA PPP2CB	7.51e-04	17	34	2	M27083
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2CA PPP2CB	7.51e-04	17	34	2	M919
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2CA PPP2CB	8.43e-04	18	34	2	MM14759
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	PPP2CA PPP2CB	9.41e-04	19	34	2	M47525
Pathway	REACTOME_ERK_MAPK_TARGETS	PPP2CA PPP2CB	9.41e-04	19	34	2	MM14780
Pathway	KEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING	PPP2CA PPP2CB	1.04e-03	20	34	2	M47876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2CA PPP2CB	1.15e-03	21	34	2	M5876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2CA PPP2CB	1.15e-03	21	34	2	MM14996
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNAT3 GNAI1	1.27e-03	22	34	2	MM15016
Pathway	REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION	PPP2CA PPP2CB	1.27e-03	22	34	2	M6768
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNAT3 GNAI1	1.27e-03	22	34	2	M841
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY	PPP2CA PPP2CB	1.27e-03	22	34	2	M47919
Pathway	REACTOME_ERK_MAPK_TARGETS	PPP2CA PPP2CB	1.27e-03	22	34	2	M13408
Pathway	REACTOME_DARPP_32_EVENTS	PPP2CA PPP2CB	1.51e-03	24	34	2	M751
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	PPP2CA PPP2CB	1.64e-03	25	34	2	MM15379
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	PPP2CA PPP2CB	1.64e-03	25	34	2	M808
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3H TBC1D3G TBC1D3B	1.72e-03	99	34	3	M46448
Pathway	REACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES	PPP2CA PPP2CB CLASP1	1.77e-03	100	34	3	MM14561
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	NFYA PPP2CA PPP2CB	1.82e-03	101	34	3	MM15829
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	NFYA PPP2CA PPP2CB	1.82e-03	101	34	3	M39387
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	PPP2CA PPP2CB	1.91e-03	27	34	2	MM14779
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	PPP2CA PPP2CB	2.05e-03	28	34	2	MM15132
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING	PPP2CA PPP2CB	2.20e-03	29	34	2	M27528
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING	PPP2CA PPP2CB	2.20e-03	29	34	2	MM15253
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	PPP2CA PPP2CB GNAI1	2.20e-03	108	34	3	M17034
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	PPP2CA PPP2CB CLASP1	2.38e-03	111	34	3	M27673
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	PPP2CA PPP2CB	2.51e-03	31	34	2	M27400
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING	PPP2CA PPP2CB	2.51e-03	31	34	2	M27529
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING	PPP2CA PPP2CB	2.51e-03	31	34	2	MM15254
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	PPP2CA PPP2CB	2.51e-03	31	34	2	MM15154
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	PPP2CA PPP2CB	2.51e-03	31	34	2	M15195
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	PPP2CA PPP2CB CLASP1	2.76e-03	117	34	3	MM15387
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING	PPP2CA PPP2CB	2.84e-03	33	34	2	M27526
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING	PPP2CA PPP2CB	2.84e-03	33	34	2	MM15252
Pathway	WP_ENDOTHELIN_PATHWAYS	GNAI1 GUCY1B2	2.84e-03	33	34	2	M39651
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNAT3 GNAI1	2.84e-03	33	34	2	MM15020
Pathway	WP_PURINERGIC_SIGNALING	GNAT3 GNAI1	2.84e-03	33	34	2	M39855
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNAT3 GNAI1	2.84e-03	33	34	2	M9379
Pathway	REACTOME_SIGNALING_BY_ERBB4	ITCH WWP1	2.84e-03	33	34	2	MM14523
Pathway	REACTOME_SIGNALING_BY_WNT_IN_CANCER	PPP2CA PPP2CB	3.02e-03	34	34	2	M27405
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING	PPP2CA PPP2CB	3.02e-03	34	34	2	M27527
Pathway	REACTOME_RAF_ACTIVATION	PPP2CA PPP2CB	3.02e-03	34	34	2	M27556
Pathway	WP_GLYCOGEN_METABOLISM	PPP2CA PPP2CB	3.02e-03	34	34	2	MM15985
Pathway	WP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME	PPP2CA PPP2CB	3.02e-03	34	34	2	M42555
Pathway	REACTOME_RAF_ACTIVATION	PPP2CA PPP2CB	3.20e-03	35	34	2	MM15271
Pathway	REACTOME_REGULATION_OF_TP53_DEGRADATION	PPP2CA PPP2CB	3.38e-03	36	34	2	MM15339
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	PPP2CA PPP2CB CLASP1	3.48e-03	127	34	3	M27181
Pathway	REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION	PPP2CA PPP2CB	3.57e-03	37	34	2	M27641
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	PPP2CA PPP2CB CLASP1	3.64e-03	129	34	3	MM14894
Pathway	PID_ERBB4_PATHWAY	ITCH WWP1	3.76e-03	38	34	2	M13
Pathway	REACTOME_SIGNALING_BY_FGFR3	PPP2CA PPP2CB	3.96e-03	39	34	2	MM15257
Pathway	REACTOME_SIGNALING_BY_NOTCH	ITCH WWP2	3.96e-03	39	34	2	MM14604
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	PPP2CA PPP2CB TRIO CLASP1 WWP2 MSI2	4.15e-03	649	34	6	MM15690
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	PPP2CA PPP2CB	4.16e-03	40	34	2	M39595
Pathway	REACTOME_SIGNALING_BY_FGFR3	PPP2CA PPP2CB	4.16e-03	40	34	2	M27532
Pathway	REACTOME_SIGNALING_BY_FGFR4	PPP2CA PPP2CB	4.16e-03	40	34	2	MM15258
Pathway	PID_ER_NONGENOMIC_PATHWAY	GNAI1 GNAL	4.16e-03	40	34	2	M41
Pathway	REACTOME_SIGNALING_BY_FGFR4	PPP2CA PPP2CB	4.37e-03	41	34	2	M27533
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY	PPP2CA PPP2CB	4.58e-03	42	34	2	MM15274
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	PPP2CA PPP2CB CLASP1	4.58e-03	140	34	3	M27550
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	PPP2CA PPP2CB CLASP1	4.67e-03	141	34	3	MM15266
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	GNAT3 GNAI1	4.79e-03	43	34	2	M29837
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY	PPP2CA PPP2CB	4.79e-03	43	34	2	M27560
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GNAT3 GNAI1 GNAL	4.95e-03	144	34	3	MM14501
Pathway	REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1	PPP2CA PPP2CB	5.01e-03	44	34	2	MM15377
Pubmed	Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.	MAGI2 ITCH WWP1 WWP2	4.01e-11	6	46	4	9647693
Pubmed	Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.	ITCH WWP1 WWP2	2.17e-09	3	46	3	12450395
Pubmed	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.	PPP2CA ITCH WWP1 WWP2	2.65e-09	14	46	4	31015455
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	AREL1 ITCH WWP1 WWP2	4.82e-09	16	46	4	25723849
Pubmed	Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.	ITCH WWP1 WWP2	8.65e-09	4	46	3	26701932
Pubmed	A Tunable Brake for HECT Ubiquitin Ligases.	ITCH WWP1 WWP2	2.16e-08	5	46	3	28475870
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	AREL1 ITCH WWP1 WWP2	3.92e-08	26	46	4	26949039
Pubmed	Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.	ITCH WWP1 WWP2	7.55e-08	7	46	3	31845480
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	ITCH WWP1 WWP2	1.21e-07	8	46	3	19307600
Pubmed	WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.	CSDE1 ITCH DNAJA1 WWP1 WWP2	1.90e-07	97	46	5	25071155
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	ITCH WWP1 WWP2	2.58e-07	10	46	3	25092867
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	ITCH WWP1 WWP2	3.55e-07	11	46	3	17996703
Pubmed	Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.	ITCH WWP1 WWP2	3.55e-07	11	46	3	21191027
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	ITCH WWP1 WWP2	3.55e-07	11	46	3	22773947
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3H TBC1D3G TBC1D3B	3.55e-07	11	46	3	16863688
Pubmed	Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.	ITCH WWP1 WWP2	3.55e-07	11	46	3	25963657
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	ITCH DNAJA1 WWP2	7.80e-07	14	46	3	26147758
Pubmed	Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.	MAGI2 ITCH WWP2	9.74e-07	15	46	3	23236378
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	ITCH WWP1 WWP2	1.45e-06	17	46	3	28292929
Pubmed	Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.	PPP2CA PPP2CB	1.71e-06	2	46	2	2837763
Pubmed	Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.	PPP2CA PPP2CB	1.71e-06	2	46	2	1846293
Pubmed	Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.	PPP2CA PPP2CB	1.71e-06	2	46	2	2555176
Pubmed	PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.	PPP2CA PPP2CB	1.71e-06	2	46	2	27096707
Pubmed	The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.	PPP2CA PPP2CB	1.71e-06	2	46	2	10543450
Pubmed	Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.	PPP2CA PPP2CB	1.71e-06	2	46	2	11751260
Pubmed	Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.	PPP2CA PPP2CB	1.71e-06	2	46	2	11113010
Pubmed	WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism.	WWP1 WWP2	1.71e-06	2	46	2	31965758
Pubmed	Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.	PPP2CA PPP2CB	1.71e-06	2	46	2	34902541
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	ITCH WWP1 WWP2	2.07e-06	19	46	3	21572392
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	ITCH WWP1 WWP2	2.83e-06	21	46	3	37005481
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	ITCH WWP1 WWP2	2.83e-06	21	46	3	29416926
Pubmed	USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.	ITCH WWP1 WWP2	3.28e-06	22	46	3	24850914
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 NSD1 MAGI2 PPP2CB GNAI1 ITCH TRIO CLASP1 DNAJA1	4.05e-06	963	46	9	28671696
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	MAGI2 ITCH WWP1	4.88e-06	25	46	3	23873930
Pubmed	Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.	PPP2CA PPP2CB	5.13e-06	3	46	2	7510677
Pubmed	The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.	ITCH WWP2	5.13e-06	3	46	2	29925997
Pubmed	The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.	PPP2CA PPP2CB	5.13e-06	3	46	2	8206937
Pubmed	Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.	ITCH WWP2	5.13e-06	3	46	2	19997087
Pubmed	Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.	PPP2CA PPP2CB	5.13e-06	3	46	2	10441131
Pubmed	Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.	PPP2CA PPP2CB	5.13e-06	3	46	2	23341017
Pubmed	Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.	PPP2CA PPP2CB	5.13e-06	3	46	2	8383590
Pubmed	Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.	PPP2CA PPP2CB	5.13e-06	3	46	2	15252037
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	PPP2CA PPP2CB DNAJA1 RYR3 IPO11	5.99e-06	195	46	5	17110338
Pubmed	Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.	PPP2CA PPP2CB	1.03e-05	4	46	2	21998041
Pubmed	Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.	PPP2CA PPP2CB	1.03e-05	4	46	2	9770493
Pubmed	The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.	ITCH WWP1	1.03e-05	4	46	2	27466427
Pubmed	Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.	PPP2CA PPP2CB	1.03e-05	4	46	2	7616230
Pubmed	Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.	PPP2CA PPP2CB	1.03e-05	4	46	2	9920888
Pubmed	Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.	PPP2CA PPP2CB	1.03e-05	4	46	2	11371618
Pubmed	Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.	ITCH WWP1	1.03e-05	4	46	2	19580544
Pubmed	The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.	PPP2CA PPP2CB	1.03e-05	4	46	2	21454489
Pubmed	Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.	ITCH WWP2	1.03e-05	4	46	2	20522958
Pubmed	The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.	PPP2CA PPP2CB	1.03e-05	4	46	2	14633983
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	CSDE1 GNAT3 GNAI1 GNAL RYR3	1.36e-05	231	46	5	36597993
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	CPSF1 PPP2CA PPP2CB ITCH KLHL28 ACTL8 DNAJA1	1.37e-05	604	46	7	38803224
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CSDE1 MAGI2 RIPOR1 FHIP2A CLASP1 BAZ2A	1.56e-05	407	46	6	12693553
Pubmed	Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.	WWP1 WWP2	1.71e-05	5	46	2	19366705
Pubmed	HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.	PPP2CA PPP2CB	1.71e-05	5	46	2	9009195
Pubmed	Protein phosphatase 2A interacts with and directly dephosphorylates RelA.	PPP2CA PPP2CB	1.71e-05	5	46	2	11591705
Pubmed	Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.	PPP2CA PPP2CB	1.71e-05	5	46	2	10640627
Pubmed	A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis.	WWP1 WWP2	1.71e-05	5	46	2	10903445
Pubmed	Inhibition of HECT E3 ligases as potential therapy for COVID-19.	WWP1 WWP2	1.71e-05	5	46	2	33762578
Pubmed	Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.	PPP2CA PPP2CB	1.71e-05	5	46	2	18596935
Pubmed	Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140.	WWP1 WWP2	1.71e-05	5	46	2	30392800
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CUL4A CSDE1 GNAT3 PPP2CA PPP2CB GNAI1 GNAL CLASP1 DNAJA1	1.73e-05	1155	46	9	20360068
Pubmed	Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.	ITCH WWP1 WWP2	2.40e-05	42	46	3	27578003
Pubmed	N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.	ITCH WWP2	2.56e-05	6	46	2	15252135
Pubmed	ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.	CUL4A CPSF1	2.56e-05	6	46	2	37040401
Pubmed	Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.	PPP2CA PPP2CB	2.56e-05	6	46	2	10781942
Pubmed	Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.	GNAT3 GNAI1	2.56e-05	6	46	2	25078664
Pubmed	Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.	ITCH WWP2	2.56e-05	6	46	2	37156795
Pubmed	Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.	PPP2CA PPP2CB	2.56e-05	6	46	2	20100830
Pubmed	Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.	PPP2CA PPP2CB	2.56e-05	6	46	2	29735529
Pubmed	Alpha 4 associates with protein phosphatases 2A, 4, and 6.	PPP2CA PPP2CB	2.56e-05	6	46	2	9647778
Pubmed	N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.	ITCH WWP2	2.56e-05	6	46	2	11748237
Pubmed	Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.	PPP2CA PPP2CB	2.56e-05	6	46	2	15147202
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	PPP2CA PPP2CB	2.56e-05	6	46	2	25531779
Pubmed	GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.	PPP2CA PPP2CB	3.58e-05	7	46	2	10698523
Pubmed	Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.	PPP2CA PPP2CB	3.58e-05	7	46	2	17604273
Pubmed	Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.	ITCH WWP2	3.58e-05	7	46	2	11046148
Pubmed	Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.	ITCH WWP2	3.58e-05	7	46	2	23644597
Pubmed	The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.	PPP2CA PPP2CB	3.58e-05	7	46	2	25546391
Pubmed	Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.	GNAT3 GNAI1	3.58e-05	7	46	2	34860335
Pubmed	beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.	MAGI2 ITCH	3.58e-05	7	46	2	11526121
Pubmed	X-linked microtubule-associated protein, Mid1, regulates axon development.	PPP2CA PPP2CB	3.58e-05	7	46	2	24194544
Pubmed	Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.	ITCH WWP2	4.77e-05	8	46	2	31578285
Pubmed	p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].	PPP2CA PPP2CB	4.77e-05	8	46	2	1330687
Pubmed	Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.	PPP2CA PPP2CB	4.77e-05	8	46	2	11007961
Pubmed	Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.	PPP2CA PPP2CB	4.77e-05	8	46	2	12912990
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP2CA PPP2CB	4.77e-05	8	46	2	16262633
Pubmed	Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.	PPP2CA PPP2CB	4.77e-05	8	46	2	35768646
Pubmed	Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.	PPP2CA PPP2CB	4.77e-05	8	46	2	12370081
Pubmed	The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.	ITCH WWP2	4.77e-05	8	46	2	11244092
Pubmed	Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.	ITCH WWP2	4.77e-05	8	46	2	17719543
Pubmed	Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.	PPP2CA PPP2CB	4.77e-05	8	46	2	23462102
Pubmed	Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.	ITCH WWP1 WWP2	5.41e-05	55	46	3	31985874
Pubmed	A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors.	PPP2CB GNAI1 CLASP1	5.41e-05	55	46	3	18448421
Pubmed	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.	CSDE1 PPP2CA PPP2CB DNAJA1	5.91e-05	159	46	4	31332168
Pubmed	Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.	PPP2CA PPP2CB	6.12e-05	9	46	2	18432318
Pubmed	Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.	PPP2CA PPP2CB	6.12e-05	9	46	2	12885400
Interaction	FBXL15 interactions	CUL4A ITCH WWP1 WWP2	5.41e-07	29	46	4	int:FBXL15
Interaction	WBP1L interactions	ITCH WWP1 WWP2	2.41e-06	12	46	3	int:WBP1L
Interaction	ARRDC2 interactions	CPSF1 ITCH WWP1 WWP2	6.91e-06	54	46	4	int:ARRDC2
Interaction	TMEM255A interactions	ITCH WWP1 WWP2	7.40e-06	17	46	3	int:TMEM255A
Interaction	UBE2L3 interactions	AREL1 ITCH WWP1 WWP2 MSI2 RNF170	8.10e-06	211	46	6	int:UBE2L3
Interaction	BRAF interactions	PPP2CA PPP2CB ITCH DNAJA1 WWP1 WWP2	8.33e-06	212	46	6	int:BRAF
Interaction	URI1 interactions	PPP2CA PPP2CB ITCH WWP1 WWP2	1.82e-05	143	46	5	int:URI1
Interaction	POLR2A interactions	NFYA CUL4A NSD1 CPSF1 PPP2CA ITCH WWP1 WWP2	2.55e-05	536	46	8	int:POLR2A
Interaction	ATN1 interactions	MAGI2 ITCH LYST WWP1 WWP2	6.56e-05	187	46	5	int:ATN1
Interaction	MIR19A interactions	CPSF1 WWP1 WWP2 MSI2	7.94e-05	100	46	4	int:MIR19A
Interaction	UBE2D2 interactions	NFYA AREL1 ITCH WWP1 WWP2 RNF170	8.11e-05	318	46	6	int:UBE2D2
Interaction	SEPTIN4 interactions	CUL4A AREL1 WWP2	8.88e-05	38	46	3	int:SEPTIN4
Interaction	MIR19B1 interactions	CPSF1 WWP1 WWP2 MSI2	9.24e-05	104	46	4	int:MIR19B1
Interaction	PRRG4 interactions	MAGI2 ITCH WWP1	9.60e-05	39	46	3	int:PRRG4
Interaction	LDLRAD3 interactions	ITCH WWP1	1.06e-04	7	46	2	int:LDLRAD3
Interaction	WBP1 interactions	ITCH WWP1 WWP2	1.20e-04	42	46	3	int:WBP1
Interaction	ARRDC3 interactions	CPSF1 MAGI2 ITCH WWP1 WWP2	1.53e-04	224	46	5	int:ARRDC3
Interaction	NLRP1 interactions	CUL4A DNAJA1 WWP2	1.68e-04	47	46	3	int:NLRP1
Interaction	SMAD7 interactions	CUL4A ITCH WWP1 WWP2	2.00e-04	127	46	4	int:SMAD7
Interaction	UBE2E3 interactions	CUL4A ITCH WWP2 IPO11	2.32e-04	132	46	4	int:UBE2E3
Interaction	ILDR1 interactions	ITCH WWP1	2.77e-04	11	46	2	int:ILDR1
Interaction	SMAD6 interactions	ITCH WWP1 WWP2	2.83e-04	56	46	3	int:SMAD6
Interaction	NDFIP2 interactions	ITCH WWP1 WWP2	2.83e-04	56	46	3	int:NDFIP2
Interaction	CILK1 interactions	CPSF1 A4GALT MSI2	3.14e-04	58	46	3	int:CILK1
Interaction	LDLRAD4 interactions	ITCH WWP1 WWP2	3.31e-04	59	46	3	int:LDLRAD4
Interaction	PRR14L interactions	CUL4A PPP2CA PPP2CB	3.31e-04	59	46	3	int:PRR14L
Interaction	TOP3B interactions	CSDE1 NSD1 CPSF1 PPP2CB RIPOR1 GNAI1 TRIO DNAJA1 LYST WWP1 A4GALT	3.70e-04	1470	46	11	int:TOP3B
Interaction	SSTR2 interactions	SHANK1 GNAI1	3.91e-04	13	46	2	int:SSTR2
Interaction	STRN interactions	CUL4A PPP2CA PPP2CB GNAI1	4.17e-04	154	46	4	int:STRN
Interaction	SCNN1A interactions	ITCH WWP1 WWP2	4.21e-04	64	46	3	int:SCNN1A
Interaction	DVL3 interactions	NFYA PPP2CA ITCH BHLHE40 WWP1	4.30e-04	280	46	5	int:DVL3
Interaction	UBE2D3 interactions	CUL4A AREL1 ITCH WWP1 WWP2	4.51e-04	283	46	5	int:UBE2D3
Interaction	PPP2R2C interactions	PPP2CA PPP2CB DNAJA1	4.81e-04	67	46	3	int:PPP2R2C
Interaction	LAPTM5 interactions	ITCH WWP1 WWP2	4.81e-04	67	46	3	int:LAPTM5
Interaction	STRIP2 interactions	PPP2CA PPP2CB ITCH	5.03e-04	68	46	3	int:STRIP2
Interaction	ARRDC1 interactions	ITCH WWP1 WWP2	5.03e-04	68	46	3	int:ARRDC1
Interaction	GNB5 interactions	CUL4A GNAI1 RGS11	5.03e-04	68	46	3	int:GNB5
Cytoband	7q21	MAGI2 GNAI1	7.61e-05	13	46	2	7q21
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3H TBC1D3G TBC1D3B	4.59e-04	149	46	3	chr17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr7q21	MAGI2 GNAT3 GNAI1	7.70e-04	178	46	3	chr7q21
Cytoband	17q12	TBC1D3H TBC1D3B	4.48e-03	99	46	2	17q12
Cytoband	16q22.1	RIPOR1 WWP2	5.50e-03	110	46	2	16q22.1
GeneFamily	C2 and WW domain containing	WWP1 WWP2	1.49e-05	4	29	2	838
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP2CA PPP2CB	1.92e-04	13	29	2	693
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	PPP2CA PPP2CB	4.64e-04	20	29	2	1371
GeneFamily	PHD finger proteins	NSD1 BAZ2A	9.12e-03	90	29	2	88
Coexpression	IBRAHIM_NRF1_UP	CUL4A CSDE1 PPP2CA PPP2CB AREL1 DNAJA1 RYR3	8.06e-06	420	46	7	M42509
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN	CUL4A PPP2CA AREL1 DNAJA1 BAZ2A BHLHE40 WWP2 MSI2	2.15e-05	680	46	8	M41089
Coexpression	GSE13493_DP_VS_CD8POS_THYMOCYTE_UP	RIPOR1 FHIP2A LYST WWP2 A4GALT	2.55e-05	199	46	5	M3314
Coexpression	GSE28726_ACT_CD4_TCELL_VS_ACT_NKTCELL_UP	NFYA PPP2CA GNAI1 BHLHE40 LYST	2.62e-05	200	46	5	M8312
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CSDE1 ALG8 GNAI1 A4GALT	2.09e-06	88	46	4	142d2e00ef19c0ad011a21945bf1111271056eae
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 RIPOR1 RGS11 RYR3	2.71e-05	168	46	4	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 RIPOR1 RGS11 RYR3	2.71e-05	168	46	4	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 RIPOR1 RGS11 RYR3	2.71e-05	168	46	4	315ca578c945aeeb77acda2727f3e6db8b43f43e
Disease	McCune Albright syndrome (implicated_via_orthology)	GNAT3 GNAI1	5.78e-05	8	43	2	DOID:1858 (implicated_via_orthology)
Disease	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 measurement	MAGI2 GNAI1	5.78e-05	8	43	2	EFO_0802739
Disease	Intellectual Disability	CSDE1 NSD1 PPP2CA TRIO FHIP2A	4.67e-04	447	43	5	C3714756
Disease	Epileptic encephalopathy	MAGI2 RYR3	8.79e-04	30	43	2	C0543888
Disease	Global developmental delay	CSDE1 PPP2CA FHIP2A	9.68e-04	133	43	3	C0557874
Disease	Anxiety Disorders	SHANK1 MAGI2	1.89e-03	44	43	2	C0003469
Disease	Anxiety neurosis (finding)	SHANK1 MAGI2	1.89e-03	44	43	2	C1279420
Disease	Anxiety States, Neurotic	SHANK1 MAGI2	1.89e-03	44	43	2	C0376280
Disease	venous thromboembolism	GNAL ITCH IPO11 A4GALT	4.45e-03	460	43	4	EFO_0004286
Disease	nicotine dependence	GNAI1 GNAL	5.81e-03	78	43	2	EFO_0003768
Disease	Autistic Disorder	SHANK1 CSDE1 NSD1	6.50e-03	261	43	3	C0004352
Disease	feeling nervous measurement	AREL1 ITCH	7.17e-03	87	43	2	EFO_0009597

Protein segments in the cluster

Peptide	Gene	Start	Entry
LNGAFLAFERRHEFM	A4GALT	216	Q9NPC4
GFTKRLFRELMGDHV	ACTL8	306	Q9H568
DSEVGKAGHIMRRFF	BAZ2A	1876	Q9UIF9
FKSDHGRRFTMGERI	BHLHE40	261	O14503
MAMRLILFFGALFGH	CPA2	1	P48052
GFIKCVDRDVRMFFH	CSDE1	361	O75534
KDHAVFTRRGEDLFM	DNAJA1	246	P31689
LMFDKTTNRHRGFGF	MSI2	141	Q96DH6
KMRHDVGEFPVLFFG	NSD1	1786	Q96L73
PVGRAHFMDFLGKEF	RGS11	311	O94810
FKDLHFKMFDVGGQR	GNAI1	191	P63096
FKDLHFRMFDVGGQR	GNAT3	191	A8MTJ3
MIFGKAHEFIELIFG	MAGEC3	496	Q8TD91
ELDVHLRRMESGFGF	MAGI2	776	Q86UL8
MGFLHGIFERLKQFL	IPO11	236	Q9UI26
FGGMRLLRRADFHVG	CPSF1	1291	Q10570
QFHDLMELFRIGGKS	PPP2CB	61	P62714
QFHDLMELFRIGGKS	PPP2CA	61	P67775
FHMFDVGGQRDERRK	GNAL	206	P38405
LFGSEFFMGRLVKRI	PLA2G4E	551	Q3MJ16
IGRFIAMALFHGKFI	ITCH	641	Q96J02
LKRVFGMFAHTEDRE	HCRTR2	326	O43614
ADKRIHFGVGVMLGF	KLHL28	466	Q9NXS3
GERFMKFSRVARGCH	CARD6	796	Q9BX69
IMILFRFIHGKDVFE	CUL4A	436	Q13619
HLRLKMYEFAGRLVG	AREL1	546	O15033
FIEMFFGRHIGLDEE	LYST	2396	Q99698
FEGHFLKVLFDRMGR	FHIP2A	631	Q5W0V3
HAMARKRGEGGRFFS	NFYA	306	P23511
FRVERGADGKMFLHY	GUCY1B2	41	O75343
LRHAFREMFSVGGLF	RNF170	181	Q96K19
GHRMNIDRALKFFLE	SHANK1	2146	Q9Y566
FQKRHMEGAFLFAVL	ALG8	181	Q9BVK2
RMLGGFKHKNFRTRE	CLASP1	131	Q7Z460
GTLRKHMFFRDRYGT	TBC1D3B	151	A6NDS4
GTLRKHMFFRDRYGT	TBC1D3H	151	P0C7X1
RFIGRFIAMALYHGK	WWP2	606	O00308
FGGREHVLMFAKLAL	TMEM175	411	Q9BSA9
KDGRFHLRVFMEAVL	ZP1	106	P60852
DFLKSHIKRGFREGF	SPATA46	196	Q5T0L3
KVRFLMGGRHGEFKF	RYR3	786	Q15413
GRFIAMALFHGKFID	WWP1	661	Q9H0M0
LGEFHLRMKGLAGFA	RIPOR1	206	Q6ZS17
GTLRKHMFFRDRYGT	TBC1D3G	151	Q6DHY5
IRKGRERHLFLFEMS	TRIO	1501	O75962
KEGRRHGFGQLMFAD	MORN4	21	Q8NDC4