Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	mammary duct terminal end bud growth	MST1 ROBO1 MST1L	5.98e-06	9	87	3	GO:0060763
GeneOntologyBiologicalProcess	epithelium development	FOXJ2 MST1 KRT3 FLNB RBM15 PSG6 BRPF1 DVL3 ROBO1 DSG4 MST1L PLXND1 HRNR BRSK1 RFX3 KRT25 PCK1 TJP3	3.42e-05	1469	87	18	GO:0060429
GeneOntologyCellularComponent	intermediate filament cytoskeleton	DES KRT3 CSNK1A1L MDN1 LMNA KRTAP1-4 KRTAP1-1 KRTAP1-3 KRT25	1.65e-06	263	88	9	GO:0045111
GeneOntologyCellularComponent	keratin filament	KRT3 CSNK1A1L KRTAP1-4 KRTAP1-1 KRTAP1-3 KRT25	3.40e-06	97	88	6	GO:0045095
GeneOntologyCellularComponent	intermediate filament	DES KRT3 CSNK1A1L LMNA KRTAP1-4 KRTAP1-1 KRTAP1-3 KRT25	5.21e-06	227	88	8	GO:0005882
GeneOntologyCellularComponent	nuclear speck	RBM15 CSNK1A1L LMNA PTPRH ACIN1 TFIP11 TUT1 WTAP	4.66e-04	431	88	8	GO:0016607
GeneOntologyCellularComponent	RNA N6-methyladenosine methyltransferase complex	RBM15 WTAP	6.19e-04	9	88	2	GO:0036396
Domain	IF	DES KRT3 LMNA LZTS3 KRT25	2.78e-05	76	87	5	IPR001664
Domain	PAN_AP	MST1 MST1L	2.13e-04	5	87	2	SM00473
Domain	Na_trans_cytopl	SCN2A SCN3A	3.18e-04	6	87	2	PF11933
Domain	Na_trans_cytopl	SCN2A SCN3A	3.18e-04	6	87	2	IPR024583
Domain	Filament	DES KRT3 LMNA KRT25	3.36e-04	71	87	4	SM01391
Domain	IF	DES KRT3 LMNA KRT25	3.55e-04	72	87	4	PS00226
Domain	Filament	DES KRT3 LMNA KRT25	3.74e-04	73	87	4	PF00038
Domain	PAN	MST1 MST1L	4.44e-04	7	87	2	PS50948
Domain	Pan_app	MST1 MST1L	4.44e-04	7	87	2	IPR003609
Domain	PAP_assoc	TENT4A TUT1	4.44e-04	7	87	2	PF03828
Domain	PAP_assoc	TENT4A TUT1	4.44e-04	7	87	2	IPR002058
Domain	PAN_1	MST1 MST1L	4.44e-04	7	87	2	PF00024
Domain	Keratin_B2	KRTAP1-4 KRTAP1-1 KRTAP1-3	8.52e-04	40	87	3	PF01500
Domain	Na_channel_asu	SCN2A SCN3A	9.42e-04	10	87	2	IPR001696
Domain	Na_trans_assoc	SCN2A SCN3A	9.42e-04	10	87	2	IPR010526
Domain	Na_trans_assoc	SCN2A SCN3A	9.42e-04	10	87	2	PF06512
Domain	MAM_1	MEP1B PTPRU	2.47e-03	16	87	2	PS00740
Domain	KAP	KRTAP1-4 KRTAP1-1 KRTAP1-3	2.50e-03	58	87	3	IPR002494
Domain	Kringle	MST1 MST1L	2.79e-03	17	87	2	IPR000001
Domain	Kringle_CS	MST1 MST1L	2.79e-03	17	87	2	IPR018056
Domain	KRINGLE_2	MST1 MST1L	2.79e-03	17	87	2	PS50070
Domain	Kringle	MST1 MST1L	2.79e-03	17	87	2	PF00051
Domain	KRINGLE_1	MST1 MST1L	2.79e-03	17	87	2	PS00021
Domain	MAM	MEP1B PTPRU	2.79e-03	17	87	2	SM00137
Domain	KR	MST1 MST1L	2.79e-03	17	87	2	SM00130
Domain	MAM	MEP1B PTPRU	3.13e-03	18	87	2	PF00629
Domain	MAM_dom	MEP1B PTPRU	3.13e-03	18	87	2	IPR000998
Domain	MAM_2	MEP1B PTPRU	3.13e-03	18	87	2	PS50060
Domain	Intermediate_filament_CS	DES KRT3 LMNA	3.17e-03	63	87	3	IPR018039
Domain	Cyclophilin-type_PPIase_CS	PPIB PPIC	3.48e-03	19	87	2	IPR020892
Domain	Cyclophilin-type_PPIase	PPIB PPIC	4.25e-03	21	87	2	IPR024936
Domain	Cyclophilin-like_dom	PPIB PPIC	4.66e-03	22	87	2	IPR029000
Domain	CSA_PPIASE_2	PPIB PPIC	4.66e-03	22	87	2	PS50072
Domain	Pro_isomerase	PPIB PPIC	4.66e-03	22	87	2	PF00160
Domain	-	PPIB PPIC	4.66e-03	22	87	2	2.40.100.10
Domain	Cyclophilin-type_PPIase_dom	PPIB PPIC	4.66e-03	22	87	2	IPR002130
Domain	CSA_PPIASE_1	PPIB PPIC	4.66e-03	22	87	2	PS00170
Domain	Ig_2	PSG6 BCAM IL1RL2	4.80e-03	73	87	3	PF13895
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLNB PDIA6 HSPA12A ASRGL1 CSNK1A1L LMNA LZTS3 WDR7 SCN2A EIF4B AAK1 FGA SNX27 DLAT GRIA1 BRSK1 PRDX5 EPB41L3 PPIB	2.49e-09	1431	88	19	37142655
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ACSL3 RBM15 PDIA6 RNF169 WAPL MDN1 LMNA BRPF1 EIF4B AAK1 ACIN1 TFIP11 MN1 WTAP	9.15e-09	774	88	14	15302935
Pubmed	Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family.	KRTAP1-4 KRTAP1-1 KRTAP1-3	6.25e-08	4	88	3	12228244
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ACSL3 DES KRT3 AP1AR FLNB PDIA6 MDN1 LMNA EIF4B DLAT ACIN1 GRIA1 EPB41L3 PPIB PCK1 DOP1A	6.06e-07	1442	88	16	35575683
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	ACSL3 AP1AR RBM15 PDIA6 CSNK1A1L LMNA WDR7 DLAT ROBO1 ARFIP2 EPB41L3 PPIB NNT	8.06e-07	952	88	13	38569033
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	KRT3 PTPRH DPEP3 EIF4B HERC2 HRNR PTPRU PPIB DOP1A	1.23e-06	420	88	9	28065597
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ACSL3 FLNB RBM15 PDIA6 WAPL MDN1 LMNA AAK1 SNX27 DLAT ACIN1 TFIP11 HERC2 EPB41L3 PPIB	1.44e-06	1353	88	15	29467282
Pubmed	Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass.	MST1 MST1L PPIB	1.85e-06	10	88	3	26378466
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	DES ACAD8 ABCB8 FGA DLAT PRDX5 NNT CSRP3	2.05e-06	331	88	8	29199018
Pubmed	Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.	MST1 MST1L BECN1	2.55e-06	11	88	3	24141421
Pubmed	TRIM6 promotes colorectal cancer cells proliferation and response to thiostrepton by TIS21/FoxM1.	LMNA EIF4B FGA HRNR	4.38e-06	43	88	4	31992359
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ACSL3 FLNB HSPA12A ASRGL1 LMNA LZTS3 EIF4B AAK1 DVL3 DLAT GRIA1 PRDX5 EPB41L3	5.74e-06	1139	88	13	36417873
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ACSL3 FLNB RBM15 MDN1 LMNA DLAT ACIN1 HERC2 EPB41L3 NNT	6.16e-06	653	88	10	22586326
Pubmed	Expression patterns of intermediate filament proteins desmin and lamin A in the developing conduction system of early human embryonic hearts.	DES LMNA	6.33e-06	2	88	2	31670395
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	6.33e-06	2	88	2	20346423
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	6.33e-06	2	88	2	29760744
Pubmed	Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis.	PPIB PPIC	6.33e-06	2	88	2	9045699
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	6.33e-06	2	88	2	11245985
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	6.33e-06	2	88	2	8393443
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	6.33e-06	2	88	2	27609031
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	6.33e-06	2	88	2	24980820
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	6.33e-06	2	88	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	6.33e-06	2	88	2	27153334
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	6.33e-06	2	88	2	31206688
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	6.33e-06	2	88	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	6.33e-06	2	88	2	16961763
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	6.33e-06	2	88	2	39253972
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	6.33e-06	2	88	2	32017081
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	6.33e-06	2	88	2	30708325
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	6.33e-06	2	88	2	24409221
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	6.33e-06	2	88	2	27696525
Pubmed	Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.	PPIB PPIC	6.33e-06	2	88	2	24990953
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	6.33e-06	2	88	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	6.33e-06	2	88	2	9486989
Pubmed	Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.	PPIB PPIC	6.33e-06	2	88	2	7909608
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	6.33e-06	2	88	2	33887258
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	6.33e-06	2	88	2	25938541
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FLNB RBM15 PDIA6 RNF169 WAPL MDN1 LMNA EIF4B DLAT ACIN1 TFIP11 NUDCD1	7.38e-06	989	88	12	36424410
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ACSL3 FLNB RBM15 PDIA6 MDN1 LMNA IRF2BP1 ACIN1 HERC2 HRNR PPIB NNT	1.05e-05	1024	88	12	24711643
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	FLNB EIF4B HRNR EPB41L3	1.10e-05	54	88	4	25631074
Pubmed	Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate.	FLNB LMNA EIF4B PRDX5 PPIB	1.19e-05	116	88	5	27576135
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	ACSL3 CSNK1A1L LZTS3 EIF4B SCP2 GRIA1 HERC2 PPIB	1.39e-05	430	88	8	32581705
Pubmed	A novel custom resequencing array for dilated cardiomyopathy.	DES LMNA CSRP3	1.47e-05	19	88	3	20474083
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A	1.90e-05	3	88	2	19284629
Pubmed	Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.	PPIB PPIC	1.90e-05	3	88	2	1618811
Pubmed	The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.	ZCCHC14 TENT4A	1.90e-05	3	88	2	35867748
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	1.90e-05	3	88	2	10225971
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN2A SCN3A	1.90e-05	3	88	2	12610651
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	1.90e-05	3	88	2	38430683
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	1.90e-05	3	88	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	1.90e-05	3	88	2	19339990
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	1.90e-05	3	88	2	26698664
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	1.90e-05	3	88	2	30063115
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN2A SCN3A	1.90e-05	3	88	2	23859570
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	1.90e-05	3	88	2	27218122
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	1.90e-05	3	88	2	17395874
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN2A SCN3A	1.90e-05	3	88	2	18784617
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	1.90e-05	3	88	2	24852423
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN2A SCN3A	1.90e-05	3	88	2	17544618
Pubmed	Proteomics study reveals that the dysregulation of focal adhesion and ribosome contribute to early pregnancy loss.	DES LMNA	1.90e-05	3	88	2	26947931
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	1.90e-05	3	88	2	27496379
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	1.90e-05	3	88	2	12804176
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	1.90e-05	3	88	2	12606483
Pubmed	A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.	RBM15 WTAP	1.90e-05	3	88	2	26190105
Pubmed	An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney.	PPIB PPIC	1.90e-05	3	88	2	8203464
Pubmed	Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.	SCN2A SCN3A	1.90e-05	3	88	2	16052353
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	1.90e-05	3	88	2	36623453
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	1.90e-05	3	88	2	37184367
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	1.90e-05	3	88	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	1.90e-05	3	88	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	1.90e-05	3	88	2	25049204
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	1.90e-05	3	88	2	1832957
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	1.90e-05	3	88	2	25183307
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	1.90e-05	3	88	2	35525373
Pubmed	Variations of sequences and amino acid compositions of proteins that sustain their biological functions: An analysis of the cyclophilin family of proteins.	PPIB PPIC	1.90e-05	3	88	2	10545201
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	1.90e-05	3	88	2	27510910
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	1.90e-05	3	88	2	31976559
Pubmed	Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.	MST1 MST1L	1.90e-05	3	88	2	32468668
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN2A SCN3A	1.90e-05	3	88	2	14973256
Pubmed	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	MST1 MST1L	1.90e-05	3	88	2	29127009
Pubmed	Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.	MST1 MST1L	1.90e-05	3	88	2	27465533
Pubmed	Amelioration of desmin network defects by αB-crystallin overexpression confers cardioprotection in a mouse model of dilated cardiomyopathy caused by LMNA gene mutation.	DES LMNA	1.90e-05	3	88	2	30342008
Pubmed	Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.	MST1 MST1L	1.90e-05	3	88	2	30771091
Pubmed	MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.	MST1 MST1L	1.90e-05	3	88	2	34967918
Pubmed	Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.	MST1 MST1L	1.90e-05	3	88	2	38898027
Pubmed	WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.	MST1 MST1L	1.90e-05	3	88	2	32045478
Pubmed	Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.	ZCCHC14 TENT4A	1.90e-05	3	88	2	32451488
Pubmed	Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.	MST1 MST1L	1.90e-05	3	88	2	27940445
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTYH1 FLNB WAPL ACAD8 HECTD4 DVL3 DLAT ROBO1 CRTAC1 TFIP11 HERC2 MED13L BECN1	2.06e-05	1285	88	13	35914814
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ZCCHC14 RBM15 LZTS3 EIF4B SNX27 ACIN1 TFIP11 HERC2 EPB41L3 PPIB WTAP	2.14e-05	922	88	11	27609421
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	ACSL3 FLNB RBM15 LMNA EIF4B DLAT ACIN1 PPIB	2.91e-05	477	88	8	31300519
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CSNK1A1L MDN1 LZTS3 WDR7 HECTD4 AAK1 GRIA1 HERC2 BRSK1 EPB41L3 PPIB	3.18e-05	963	88	11	28671696
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN2A SCN3A	3.79e-05	4	88	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN2A SCN3A	3.79e-05	4	88	2	35031483
Pubmed	Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.	MST1 MST1L	3.79e-05	4	88	2	21078906
Pubmed	MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.	MST1 MST1L	3.79e-05	4	88	2	36618429
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN2A SCN3A	3.79e-05	4	88	2	29578003
Pubmed	Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.	MST1 MST1L	3.79e-05	4	88	2	35715527
Pubmed	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.	MST1 MST1L	3.79e-05	4	88	2	25074980
Pubmed	OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.	MST1 MST1L	3.79e-05	4	88	2	27825852
Interaction	USP7 interactions	MEP1B RBM15 RNF169 MDN1 LMNA LZTS3 BRPF1 SCN2A UVSSA EIF4B SCN3A SNX27 TFIP11 HRNR BECN1 NNT DDX4 WTAP	8.72e-06	1313	86	18	int:USP7
Interaction	KCTD13 interactions	FLNB PDIA6 HSPA12A ASRGL1 LMNA LZTS3 WDR7 SCN2A EIF4B AAK1 FGA SNX27 DLAT GRIA1 BRSK1 PRDX5 EPB41L3 PPIB	1.96e-05	1394	86	18	int:KCTD13
Interaction	MXD3 interactions	KRTAP1-1 KRTAP1-3 TFIP11 PCK1	2.51e-05	40	86	4	int:MXD3
Interaction	C1R interactions	SNX27 DSG4 PCK1	3.29e-05	15	86	3	int:C1R
GeneFamily	Non-canonical poly(A) polymerases	TENT4A TUT1	2.40e-04	7	62	2	1318
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN3A	4.10e-04	9	62	2	1203
GeneFamily	Cyclophilin peptidylprolyl isomerases	PPIB PPIC	1.91e-03	19	62	2	909
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRH PTPRU	2.33e-03	21	62	2	813
ToppCell	Tuft-tuft-4\|World / Class top	FLNB HSPA12A MDN1 WDR7 RNF39 MN1	1.28e-06	174	88	6	d6f306ebf66061bf9e9742000bfedce12d277452
Disease	Malignant neoplasm of breast	MST1 ZCCHC14 DES FLNB KIF6 ZNF277 ABCB8 DVL3 SCP2 ROBO1 HERC2 PRDX5 EPB41L3 DOP1A	1.44e-06	1074	82	14	C0006142
Disease	cup-to-disc ratio measurement, optic cup area measurement, optic disc area measurement	KIF6 HSPA12A EPB41L3	2.45e-06	10	82	3	EFO_0006937, EFO_0006939, EFO_0006940
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L EPB41L3	4.55e-05	25	82	3	DOID:0050589 (implicated_via_orthology)
Disease	Primary familial dilated cardiomyopathy	DES LMNA CSRP3	7.96e-05	30	82	3	cv:C0340427
Disease	Primary dilated cardiomyopathy	DES LMNA CSRP3	1.16e-04	34	82	3	cv:C0007193
Disease	dilated cardiomyopathy (is_implicated_in)	DES LMNA CSRP3	2.36e-04	43	82	3	DOID:12930 (is_implicated_in)
Disease	Cardiomyopathy	DES LMNA CSRP3	3.07e-04	47	82	3	cv:C0878544
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN3A	3.38e-04	10	82	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN3A	3.38e-04	10	82	2	DOID:0080422 (implicated_via_orthology)
Disease	Muscular dystrophy, limb-girdle, autosomal dominant	DES LMNA	3.38e-04	10	82	2	cv:C5675009
Disease	arrhythmogenic right ventricular cardiomyopathy (is_implicated_in)	DES LMNA	3.38e-04	10	82	2	DOID:0050431 (is_implicated_in)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN3A	4.94e-04	12	82	2	DOID:0060170 (implicated_via_orthology)
Disease	Ischemic stroke, tissue plasminogen activator measurement	HECTD4 FGA	7.82e-04	15	82	2	EFO_0004791, HP_0002140
Disease	central nervous system disease (implicated_via_orthology)	IRF2BP1 GRIA1	8.93e-04	16	82	2	DOID:331 (implicated_via_orthology)
Disease	Ischemic stroke, plasminogen activator inhibitor 1 measurement	HECTD4 FGA	8.93e-04	16	82	2	EFO_0004792, HP_0002140
Disease	factor XI measurement, Ischemic stroke	HECTD4 FGA	1.01e-03	17	82	2	EFO_0004694, HP_0002140
Disease	Dystonia, Paroxysmal	SCP2 DLAT	1.13e-03	18	82	2	C0393588
Disease	epilepsy (biomarker_via_orthology)	GRIA1 BECN1	1.55e-03	21	82	2	DOID:1826 (biomarker_via_orthology)
Disease	Intellectual Disability	SCN3A SNX27 ACIN1 GRIA1 MED13L MN1	1.55e-03	447	82	6	C3714756
Disease	anxiety disorder (implicated_via_orthology)	SCN2A SCN3A	1.70e-03	22	82	2	DOID:2030 (implicated_via_orthology)
Disease	Limb-girdle muscular dystrophy	DES LMNA	2.37e-03	26	82	2	cv:C0686353

Protein segments in the cluster

Peptide	Gene	Start	Entry
GCTGIGIGFYGNSET	TTYH1	101	Q9H313
GGTRGVLSGNRGVEY	ACIN1	11	Q9UKV3
VLSGNRGVEYGSGRG	ACIN1	16	Q9UKV3
RSGSGSERGGYKGLN	DDX4	201	Q9NQI0
FGGVYIQTDVGGSGL	ACAD8	86	Q9UKU7
STSGLGSGYIGRVFG	AAK1	26	Q2M2I8
GGYADNDIGAVSTTG	ASRGL1	206	Q7L266
SVAGLETTYTGGNGF	DOP1A	2271	Q5JWR5
NETSIVSGGYGGSGD	ARFIP2	46	P53365
QRVGGGGGSKYFRTC	AP1AR	21	Q63HQ0
GQSNERGDGGIYIGS	DVL3	266	Q92997
RGGSREYDTGGGSSS	RBM15	106	Q96T37
REIISFGSGYGGNSL	PCK1	226	P35558
DGTGRLYVIGTGERG	NUDCD1	131	Q96RS6
TVTRSYRSVGGSGGG	LMNA	621	P02545
YIDGIGSGVTSSGFG	MDN1	1641	Q9NU22
RGGGTASGQGSVKYD	MED13L	1061	Q71F56
GGSGYQDLGTSDSGR	LZTS3	266	O60299
GKGEGYRGTANTTTA	MST1L	256	Q2TV78
YGAGGRLGIGGTESV	HERC2	4011	O95714
GGSQGFSGRSAVVSG	KRT3	11	P12035
GKIEDTGGSGGSYSI	BECN1	401	Q14457
TNTYAAGGTVEGGVS	DSG4	716	Q86SJ6
GGTLLGVSSQGGQTY	CYP2S1	206	Q96SQ9
LVSAYGTGLEGGTTG	FLNB	2386	O75369
GAGGSRLLVGATYTG	PLXND1	201	Q9Y4D7
LRGEGATSYGGGAAQ	OR2Z1	86	Q8NG97
NSVTTGYGGVRALCG	DLAT	46	P10515
GSGSSQSSGYGRQGS	HRNR	1106	Q86YZ3
GSGSSQSSGYGRQGS	HRNR	1576	Q86YZ3
GSGSSQSSGYGRQGS	HRNR	2046	Q86YZ3
GSGSSQSSGYGRQGS	HRNR	2516	Q86YZ3
YGQTGSGKTFTITGG	KIF6	96	Q6ZMV9
LRLYGGGTSFGTGNS	KRT25	21	Q7Z3Z0
IGYGQEGSSGAVSTR	KRTAP1-1	101	Q07627
IGYGQEGSSGAVSTR	KRTAP1-3	91	Q8IUG1
GYGQEGSGGSVSTRI	KRTAP1-4	46	P0C5Y4
AAVNGYSGSDTVGAG	HSPA12A	261	O43301
GSFGDVYLGITTTNG	CSNK1A1L	26	Q8N752
IASYSQGTGSVDGGA	FOXJ2	201	Q9P0K8
GNTLGYGSRSVLGTG	HECTD4	696	Q9Y4D8
GSTGYVGSSRGGENT	ODAD1	611	Q96M63
TSQGVGRGGSGFASY	TENT4A	6	Q5XG87
GYSTRGDQRSGGVTE	PTPRU	831	Q92729
RSAGYILVGGAGGQS	PRDX5	11	P30044
GITVSITERAGYGGS	IL1RL2	211	Q9HB29
KVYVTGGRGSENGVS	KLHL25	341	Q9H0H3
SGGRVAVIGGGYCVS	SDR9C7	161	Q8NEX9
SRVYQVSRTSGGAGG	DES	51	P17661
GSGGGGIYSVTFTLI	BRSK1	681	Q8TDC3
GNEITRGGSTSYGTG	FGA	266	P02671
EAGVSKYTGGRGVSV	CRTAC1	231	Q9NQ79
SEFIGIGGNYDGTGR	DPEP3	351	Q9H4B8
SSEERTGRGGSGYVN	WTAP	316	Q15007
TGRGGSGYVNQLSAG	WTAP	321	Q15007
GKGEGYRGTANTTTA	MST1	286	P26927
IGYGQGAGCLSTDTG	CSRP3	71	P50461
GASSGGSGENGRVVS	GRIA1	866	P42261
GVTRGQSGTYGCRVE	BCAM	326	P50895
SNGTQFRRGGGYGTS	MEP1B	546	Q16820
GEVGTGQYATTKGIS	EPB41L3	446	Q9Y2J2
GTGGGVSGQDRYDRA	IRF2BP1	101	Q8IU81
AGDTGGDTVGYTETS	MLNR	391	O43193
GRSGGYSSGKQGRSD	PDIA6	141	Q15084
LAEDGGTGGGSTYVS	EIF4B	21	P23588
YNTVVGERGTTLSGG	ABCB8	601	Q9NUT2
EGGSTGAGRLGTFEQ	MN1	606	Q10571
NVILGGYGTTSTAGG	NNT	886	Q13423
GQDLGSSRYSGKGRG	UVSSA	636	Q2YD98
ITTGDGTGGVSIYGE	PPIC	101	P45877
GVTGGQLISSSGGTY	RFX3	121	P48380
RGDGTGGVTGYFTVT	PSG6	126	Q00889
DFTRGDGTGGKSIYG	PPIB	106	P23284
LNYLRDGNGTTSGVG	SCN3A	1061	Q9NY46
GGGSGTSLEREQFEG	RNF169	536	Q8NCN4
QGATLVDRGDNTYGG	SCP2	326	P22307
VRYGSGSGQQSVTGV	SDF2	46	Q99470
TENEAYSVGTGRGVG	BRPF1	1046	P55201
VGQGYGLTESAGAGT	ACSL3	471	O95573
RTRSEGGGTGESSQG	TUT1	641	Q9H6E5
VTGGANLVSCGGSGY	WDR49	386	Q8IV35
GNGTTSGIGSSVEKY	SCN2A	1071	Q99250
TGGDEGGSGSSNYKI	WAPL	436	Q7Z5K2
SGYGFNVRGQVSEGG	SNX27	51	Q96L92
TVTYQRGGEAVSSGG	ROBO1	946	Q9Y6N7
QVGAVLGSGGFGTVY	PIM3	41	Q86V86
LGSGGFGTVYAGSRI	PIM3	46	Q86V86
TAGQGSGSYGAATLG	nan	26	Q6ZWC4
GTAGVYQTQGLVGSS	ZCCHC14	881	Q8WYQ9
QGRGYDGDSSSGSGR	TJP3	126	O95049
DRDGSCSTVGGVGYG	ZNF277	16	Q9NRM2
GVEYTGDGGRAGTRS	PTPRH	331	Q9HD43
VEYTGDGGGTETRNT	PTPRH	421	Q9HD43
ASEGVGKGTYGVSRA	WDR7	871	Q9Y4E6
GKGAVGAYGSERTTQ	TFIP11	186	Q9UBB9
GVGEKGIYTASSRGG	RNF39	31	Q9H2S5