Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF250 ZNF717 ZNF765 ZNF135 ZNF142 USF3 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 NFKB1 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	1.34e-16	1459	74	31	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF250 ZNF717 ZNF765 ZNF135 ZNF142 USF3 HIVEP2 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 NFKB1 ZNF516 YY2 ZNF696 ZNF880 ZNF439 YY1 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	3.87e-14	1412	74	28	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF250 ZNF717 ZNF765 ZNF135 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 ZNF792 KLF9 ZNF175 NFKB1 ZNF516 YY2 ZNF880 ZNF524 YY1 ZNF879 ZBTB14 ZNF585B	4.02e-10	1244	74	22	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF250 ZNF717 ZNF765 ZNF135 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 ZNF792 KLF9 ZNF175 NFKB1 ZNF516 YY2 ZNF880 ZNF524 YY1 ZNF879 ZBTB14 ZNF585B	6.02e-10	1271	74	22	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF717 USF3 HIVEP2 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 KLF9 ZNF175 NFKB1 YY2 YY1 ZNF585B	1.54e-08	560	74	14	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF717 USF3 HIVEP2 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 KLF9 ZNF175 NFKB1 YY2 YY1 ZNF585B	1.76e-08	566	74	14	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	GZF1 ZBTB17 ZNF175 NFKB1 YY1 ZBTB14	1.20e-03	320	74	6	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	GZF1 ZBTB17 ZNF175 NFKB1 YY1 ZBTB14	1.32e-03	326	74	6	GO:0001217
Domain	-	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	1.17e-21	679	74	28	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	2.11e-21	694	74	28	IPR013087
Domain	zf-C2H2	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	3.27e-20	693	74	27	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	4.03e-20	775	74	28	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	4.31e-20	777	74	28	PS00028
Domain	Znf_C2H2-like	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	8.19e-20	796	74	28	IPR015880
Domain	Znf_C2H2	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	1.10e-19	805	74	28	IPR007087
Domain	ZnF_C2H2	ZNF250 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	1.22e-19	808	74	28	SM00355
Domain	KRAB	ZNF250 ZNF765 ZNF135 ZNF585A ZNF792 ZNF175 ZNF180 ZNF880 ZNF439 ZNF879 ZNF441 ZNF585B	1.55e-08	358	74	12	PS50805
Domain	KRAB	ZNF250 ZNF765 ZNF135 ZNF585A ZNF792 ZNF175 ZNF180 ZNF880 ZNF439 ZNF879 ZNF441 ZNF585B	1.55e-08	358	74	12	PF01352
Domain	KRAB	ZNF250 ZNF765 ZNF135 ZNF585A ZNF792 ZNF175 ZNF180 ZNF880 ZNF439 ZNF879 ZNF441 ZNF585B	2.16e-08	369	74	12	SM00349
Domain	KRAB	ZNF250 ZNF765 ZNF135 ZNF585A ZNF792 ZNF175 ZNF180 ZNF880 ZNF439 ZNF879 ZNF441 ZNF585B	2.22e-08	370	74	12	IPR001909
Domain	zf-C2H2_6	ZNF250 ZNF765 ZNF135 ZNF497 GZF1 ZNF792 ZNF880 ZNF524 ZNF439 ZNF879	4.34e-07	314	74	10	PF13912
Domain	TF_Yin_yang	YY2 YY1	1.55e-05	2	74	2	IPR017114
Domain	DEATH	ANK1 NFKB1	5.10e-03	27	74	2	SM00005
Domain	WD40_repeat_dom	TECPR2 DPH7 IFT122 LYST MAPK8IP3	6.48e-03	297	74	5	IPR017986
Domain	Death	ANK1 NFKB1	7.55e-03	33	74	2	PF00531
Pubmed	Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.	TRAF6 NFKB1 USP20	4.17e-08	4	77	3	21525354
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	AKAP6 TRIM66 ALMS1 TECPR2 ERC2	3.61e-06	104	77	5	9205841
Pubmed	Yin Yang 2: the great unknown within the Yin Yang 1 regulatory network.	YY2 YY1	4.84e-06	2	77	2	22248057
Pubmed	Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.	ZNF585A ZNF585B	4.84e-06	2	77	2	37668106
Pubmed	NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes.	NFKB1 YY1	4.84e-06	2	77	2	17438126
Pubmed	The transcription factor YY2 has less momentous properties of an intrinsically disordered protein than its paralog YY1.	YY2 YY1	4.84e-06	2	77	2	31131888
Pubmed	The Forgotten YY2 in Reported YY1 Expression Levels in Human Cancers.	YY2 YY1	4.84e-06	2	77	2	29604937
Pubmed	Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis.	YY2 YY1	4.84e-06	2	77	2	35246964
Pubmed	TRAF6 neddylation drives inflammatory arthritis by increasing NF-κB activation.	TRAF6 NFKB1	4.84e-06	2	77	2	30626891
Pubmed	Genome-wide analysis of YY2 versus YY1 target genes.	YY2 YY1	4.84e-06	2	77	2	20215434
Pubmed	Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2.	YY2 YY1	4.84e-06	2	77	2	16260628
Pubmed	NFkappaB signaling is induced by the oncoprotein Tio through direct interaction with TRAF6.	TRAF6 NFKB1	4.84e-06	2	77	2	16452479
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF135 ZNF142 ZBTB17	6.94e-06	17	77	3	7557990
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF250 ZNF765 ZNF142 GZF1 VEZF1 YY2 ZNF696 RAB11FIP5 ERC2 IL17RA YY1 SNRNP200	1.28e-05	1203	77	12	29180619
Pubmed	Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6.	TRAF6 IL17RA	1.45e-05	3	77	2	17346928
Pubmed	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.	TRAF6 NFKB1	1.45e-05	3	77	2	19479062
Pubmed	YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection.	ZNF175 YY1	1.45e-05	3	77	2	19034670
Pubmed	The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.	TRAF6 NFKB1	1.45e-05	3	77	2	22863753
Pubmed	TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB.	TRAF6 NFKB1	1.45e-05	3	77	2	16436380
Pubmed	Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE).	TRAF6 NFKB1	1.45e-05	3	77	2	36177494
Pubmed	Mesenchymal Stem Cell-Derived Exosomal miR-150-3p Affects Intracerebral Hemorrhage By Regulating TRAF6/NF-κB Axis, Gut Microbiota and Metabolism.	TRAF6 NFKB1	1.45e-05	3	77	2	37099039
Pubmed	Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway.	TRAF6 NFKB1	1.45e-05	3	77	2	15591054
Pubmed	Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-kappaB pathway in Raw 264.7 murine macrophages.	RAPGEF3 NFKB1	1.45e-05	3	77	2	17532477
Pubmed	IL-17A neutralizing antibody attenuates eosinophilic meningitis caused by Angiostrongylus cantonensis by involving IL-17RA/Traf6/NF-κB signaling.	TRAF6 IL17RA	1.45e-05	3	77	2	31415761
Pubmed	Developmental expression profile of the YY2 gene in mice.	YY2 YY1	1.45e-05	3	77	2	19638226
Pubmed	Interleukin-1 receptor-associated kinase-2 genetic variant rs708035 increases NF-κB activity through promoting TRAF6 ubiquitination.	TRAF6 NFKB1	1.45e-05	3	77	2	24662294
Pubmed	A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans.	TRAF6 IL17RA	1.45e-05	3	77	2	32350852
Pubmed	miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency.	TRAF6 NFKB1	1.45e-05	3	77	2	27485827
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 TRIM66 ARHGAP5 TRAF6 HIVEP2 SLF2 ERC2 IFT122 ZNF439 SNRNP200 ZNF879 MAPK8IP3	2.46e-05	1285	77	12	35914814
Pubmed	Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.	TRAF6 NFKB1	2.89e-05	4	77	2	19820695
Pubmed	TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB.	TRAF6 NFKB1	2.89e-05	4	77	2	18070982
Pubmed	p62 regulates CD40-mediated NFκB activation in macrophages through interaction with TRAF6.	TRAF6 NFKB1	2.89e-05	4	77	2	26133577
Pubmed	C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6.	TRAF6 NFKB1	2.89e-05	4	77	2	31123462
Pubmed	Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation.	TRAF6 NFKB1	2.89e-05	4	77	2	22593207
Pubmed	Trim13 Potentiates Toll-Like Receptor 2-Mediated Nuclear Factor κB Activation via K29-Linked Polyubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6.	TRAF6 NFKB1	2.89e-05	4	77	2	28087809
Pubmed	SNHG16/miR-605-3p/TRAF6/NF-κB feedback loop regulates hepatocellular carcinoma metastasis.	TRAF6 NFKB1	2.89e-05	4	77	2	32436333
Pubmed	Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling.	TRAF6 NFKB1	2.89e-05	4	77	2	16393988
Pubmed	The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.	TRAF6 NFKB1	2.89e-05	4	77	2	16079148
Pubmed	The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.	AKAP6 RAPGEF3	2.89e-05	4	77	2	16177794
Pubmed	The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation.	TRAF6 NFKB1	2.89e-05	4	77	2	25134449
Pubmed	Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.	TRAF6 USP20	2.89e-05	4	77	2	37311534
Pubmed	TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.	TRAF6 NFKB1	2.89e-05	4	77	2	19091594
Pubmed	BAT3 negatively regulates lipopolysaccharide-induced NF-κB signaling through TRAF6.	TRAF6 NFKB1	2.89e-05	4	77	2	27501752
Pubmed	Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism.	TRAF6 NFKB1	2.89e-05	4	77	2	14593105
Pubmed	Galiximab signals B-NHL cells and inhibits the activities of NF-κB-induced YY1- and snail-resistant factors: mechanism of sensitization to apoptosis by chemoimmunotherapeutic drugs.	NFKB1 YY1	2.89e-05	4	77	2	22267549
Pubmed	Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression.	TRAF6 NFKB1	2.89e-05	4	77	2	26048146
Pubmed	The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.	TRAF6 IL17RA	2.89e-05	4	77	2	17277779
Pubmed	Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.	TRAF6 USP20	2.89e-05	4	77	2	26839314
Pubmed	Regulation of inflammatory responses by IL-17F.	TRAF6 IL17RA	2.89e-05	4	77	2	18411338
Pubmed	A census of human transcription factors: function, expression and evolution.	USF3 HIVEP2 ZBTB17 KLF9 ZNF175 ZNF180 NFKB1 ZNF524 YY1 ZBTB14	3.16e-05	908	77	10	19274049
Pubmed	TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.	TRAF6 NFKB1	4.82e-05	5	77	2	22851696
Pubmed	The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling.	TRAF6 IL17RA	4.82e-05	5	77	2	23737552
Pubmed	Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch.	TRAF6 NFKB1	4.82e-05	5	77	2	26620909
Pubmed	HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6.	TRAF6 NFKB1	4.82e-05	5	77	2	33060567
Pubmed	IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.	TRAF6 NFKB1	4.82e-05	5	77	2	20139273
Pubmed	HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-κBYY1 pathway.	NFKB1 YY1	4.82e-05	5	77	2	24862326
Pubmed	Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation.	TRAF6 NFKB1	4.82e-05	5	77	2	29929436
Pubmed	Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements.	RAPGEF3 NFKB1	4.82e-05	5	77	2	25122553
Pubmed	Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6.	TRAF6 IL17RA	4.82e-05	5	77	2	25202827
Pubmed	RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.	TRAF6 NFKB1	4.82e-05	5	77	2	20043910
Pubmed	TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.	TRAF6 NFKB1	4.82e-05	5	77	2	18984593
Pubmed	IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination.	TRAF6 NFKB1	4.82e-05	5	77	2	17878161
Pubmed	TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.	TRAF6 NFKB1	4.82e-05	5	77	2	25371197
Pubmed	Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades.	TRAF6 NFKB1	4.82e-05	5	77	2	19365810
Pubmed	OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites.	NFKB1 YY1	4.82e-05	5	77	2	17641042
Pubmed	IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: Differential involvement of NF-κB versus JNK/AP-1 pathways.	NFKB1 IL17RA	7.22e-05	6	77	2	21145111
Pubmed	Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.	AKAP6 RAPGEF3	7.22e-05	6	77	2	23540699
Pubmed	PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.	TRAF6 NFKB1	7.22e-05	6	77	2	19903815
Pubmed	Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.	TRAF6 IL17RA	7.22e-05	6	77	2	19825828
Pubmed	Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.	NLGN1 CDH11	7.22e-05	6	77	2	34135003
Pubmed	Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.	TRAF6 YY1	7.22e-05	6	77	2	19879840
Pubmed	TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaB.	TRAF6 NFKB1	7.22e-05	6	77	2	19234489
Pubmed	Th17-associated cytokines promote human airway smooth muscle cell proliferation.	NFKB1 IL17RA	7.22e-05	6	77	2	22898922
Pubmed	The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1.	TRAF6 NFKB1	7.22e-05	6	77	2	16280329
Pubmed	Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification.	TRAF6 NFKB1	7.22e-05	6	77	2	17197697
Pubmed	The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.	TRAF6 NFKB1	7.22e-05	6	77	2	19201866
Pubmed	Mouse models of human ocular disease for translational research.	RPGRIP1 ALMS1	7.22e-05	6	77	2	28859131
Pubmed	HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages.	TRAF6 NFKB1	1.01e-04	7	77	2	23774506
Pubmed	Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.	TRAF6 NFKB1	1.01e-04	7	77	2	25515214
Pubmed	TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL.	TRAF6 NFKB1	1.01e-04	7	77	2	19112497
Pubmed	MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling.	TRAF6 NFKB1	1.01e-04	7	77	2	21115689
Pubmed	Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling.	TRAF6 NFKB1	1.01e-04	7	77	2	19843958
Pubmed	Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells.	NFKB1 YY1	1.01e-04	7	77	2	20138641
Pubmed	Specific and ubiquitous expression of different Zn finger protein genes in the mouse.	ZNF585A ZNF585B	1.01e-04	7	77	2	3143103
Pubmed	Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.	TRAF6 NFKB1	1.01e-04	7	77	2	17507094
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	USP30 ZNF792 TECPR2 ZNF175 ZNF516	1.24e-04	217	77	5	34048709
Pubmed	Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.	TRAF6 NFKB1	1.34e-04	8	77	2	19795416
Pubmed	GSK-3β controls NF-kappaB activity via IKKγ/NEMO.	TRAF6 NFKB1	1.34e-04	8	77	2	27929056
Pubmed	Negative feedback regulation of NF-κB action by CITED2 in the nucleus.	TRAF6 NFKB1	1.34e-04	8	77	2	21098220
Pubmed	The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4.	TRAF6 NFKB1	1.72e-04	9	77	2	16831874
Pubmed	HIV-1 transcription and latency: an update.	NFKB1 YY1	1.72e-04	9	77	2	23803414
Pubmed	Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes.	TRAF6 NFKB1	1.72e-04	9	77	2	20449947
Pubmed	TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.	TRAF6 TRAIP	1.72e-04	9	77	2	17544371
Pubmed	Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia.	TRAF6 NFKB1	1.72e-04	9	77	2	27257617
Pubmed	The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.	TRAF6 NFKB1	1.72e-04	9	77	2	18625728
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF585A ZNF175 ZNF585B	1.79e-04	49	77	3	9630514
Pubmed	β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation.	TRAF6 NFKB1	2.15e-04	10	77	2	22851693
Pubmed	HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.	TRAF6 NFKB1	2.15e-04	10	77	2	24912525
Pubmed	Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.	TRAF6 NFKB1	2.15e-04	10	77	2	12843241
Pubmed	HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.	TRAF6 NFKB1	2.63e-04	11	77	2	21886773
Interaction	KRTAP10-8 interactions	ZNF250 ZNF497 VEZF1 ZNF792 CLK4 ZNF696 FADS6 ZNF524 ZNF439 YY1 ZNF491 FAM221B	3.22e-08	401	76	12	int:KRTAP10-8
Interaction	KRTAP10-7 interactions	ZNF250 ZNF792 ZNF175 CLK4 ZNF180 ZNF696 FADS6 ZNF524 ZNF439 ZNF491	1.48e-07	293	76	10	int:KRTAP10-7
Interaction	TRIM41 interactions	ZNF250 ZNF497 ZNF792 TRAIP ZNF696 ZNF439 PRDM14 TOP3B	1.96e-06	223	76	8	int:TRIM41
Interaction	KRTAP10-9 interactions	ZNF497 ZNF792 CLK4 ZNF696 ZNF524 ZNF439 YY1 ZNF491	3.49e-06	241	76	8	int:KRTAP10-9
Interaction	MDFI interactions	ZNF497 ZNF696 FADS6 ZNF524 ZNF439 YY1 TOP3B USP20 ZNF491 ZNF441	4.79e-06	430	76	10	int:MDFI
Interaction	CARD10 interactions	ZNF250 ZNF180 ZNF524 ZNF439 PRDM14 TOP3B	8.48e-06	127	76	6	int:CARD10
Interaction	GOLGA6L9 interactions	ZNF250 ZNF497 ZNF628 VEZF1 ZNF792 ZNF696 ZNF524	1.72e-05	216	76	7	int:GOLGA6L9
Interaction	NOTCH2 interactions	TRIM66 ZNF765 ZNF142 ZNF497 ZBTB17 ZNF628 VEZF1 ZNF696 TOP3B	2.98e-05	423	76	9	int:NOTCH2
Interaction	ZNF473 interactions	ZNF250 ZNF497 GZF1 ZNF792	5.91e-05	56	76	4	int:ZNF473
Interaction	TEKT2 interactions	ADSL DPH7 PM20D2	9.85e-05	24	76	3	int:TEKT2
Interaction	ZNF250 interactions	ZNF250 ZNF792 ZNF175 PRDM14 TOP3B	1.14e-04	126	76	5	int:ZNF250
Interaction	ZNF835 interactions	ZNF497 ZNF792 ZNF524 PRDM14	1.34e-04	69	76	4	int:ZNF835
Interaction	ZNF585A interactions	ZNF585A TOP3B	1.39e-04	5	76	2	int:ZNF585A
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF765 ZNF135 ZNF497 ZNF585A ZNF628 ZNF792 ZNF175 ZNF180 ZNF880 ZNF524 ZNF585B	4.82e-06	1192	77	11	chr19q13
Cytoband	2p13	ALMS1 RAB11FIP5	6.87e-04	23	77	2	2p13
Cytoband	19q13.42	ZNF765 ZNF628 ZNF524	1.24e-03	125	77	3	19q13.42
Cytoband	10q11.22	FRMPD2 FRMPD2B	2.18e-03	41	77	2	10q11.22
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF250 ZNF717 ZNF765 ZNF135 ZNF142 HIVEP2 ZNF497 ZNF585A GZF1 ZBTB17 ZNF628 VEZF1 ZNF792 KLF9 ZNF175 ZNF180 ZNF516 YY2 ZNF696 ZNF880 ZNF524 ZNF439 YY1 PRDM14 ZNF879 ZNF491 ZBTB14 ZNF441 ZNF585B	4.81e-25	718	60	29	28
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_DN	ZNF135 USF3 VEZF1 KLF9 INPP5A ZNF880 LYST	2.01e-06	199	77	7	M9236
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ARHGAP5 ZNF765 ZNF585A TECPR2 ZNF441 MAPK8IP3	6.84e-07	179	77	6	5be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 RIMKLA	1.22e-05	172	77	5	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 RIMKLA	1.22e-05	172	77	5	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.78e-05	186	77	5	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.78e-05	186	77	5	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.82e-05	187	77	5	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.82e-05	187	77	5	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.82e-05	187	77	5	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.87e-05	188	77	5	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.87e-05	188	77	5	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.87e-05	188	77	5	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.92e-05	189	77	5	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	1.92e-05	189	77	5	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	2.07e-05	192	77	5	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 HJV TNNI3K ANK1 PM20D2	2.07e-05	192	77	5	d766221acfce30cbf2c60b3ae40f6744968b952c
Disease	N-acetyltyrosine measurement	ALMS1 RAB11FIP5	9.00e-05	6	73	2	EFO_0020021
Disease	N-acetylkynurenine (2) measurement	ALMS1 RAB11FIP5	2.15e-04	9	73	2	EFO_0800083
Disease	N-acetylleucine measurement	ALMS1 RAB11FIP5	2.15e-04	9	73	2	EFO_0800116
Disease	pancreatic hormone measurement	FRMPD2 FRMPD2B	2.68e-04	10	73	2	EFO_0020621
Disease	N-delta-acetylornithine measurement	ALMS1 RAB11FIP5	3.92e-04	12	73	2	EFO_0800067
Disease	N-acetylglutamine measurement	ALMS1 RAB11FIP5	4.63e-04	13	73	2	EFO_0800017
Disease	age at onset, Myopia	AKAP6 KLF9 FRMPD2 FRMPD2B	5.32e-04	150	73	4	EFO_0004847, HP_0000545
Disease	N-acetylarginine measurement	ALMS1 RAB11FIP5	7.08e-04	16	73	2	EFO_0021429
Disease	Intellectual Disability	AKAP6 ZNF142 HIVEP2 ADSL YY1 MAPK8IP3	8.45e-04	447	73	6	C3714756
Disease	retinitis pigmentosa (implicated_via_orthology)	RPGRIP1 SNRNP200	2.04e-03	27	73	2	DOID:10584 (implicated_via_orthology)
Disease	lung carcinoma, family history of lung cancer	GPATCH2 PM20D2	2.35e-03	29	73	2	EFO_0001071, EFO_0006953

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDHLTPLHVAAHCGH	ANK1	336	P16157
HQRHVHSSERHFPCE	GZF1	366	Q9H116
QHHPDKHREHMCLPL	ALMS1	3516	Q8TCU4
AVRHSHPPLEHHECH	ABCA7	41	Q8IZY2
GDPHVRSFHHHFHTC	HJV	171	Q6ZVN8
EERKPRMGLFHHHHQ	RAB11FIP5	456	Q9BXF6
HHLSDICHLIRHDVP	RIMKLA	171	Q8IXN7
DHLTKHARRHTEFHP	KLF9	216	Q13886
ENHSCFEHMHHIPAP	IL17RA	241	Q96F46
LCHGNPHDHHSVTLR	KIAA0100	1216	Q14667
HAIHRHTEDPFSVHR	IFT122	956	Q9HBG6
DLGHPHHSIRCMAVV	MAPK8IP3	1041	Q9UPT6
CSIKHGDIHFDHFHP	DDX60	991	Q8IY21
VHTHKPHFMALHCQE	INPP5A	41	Q14642
RCKHSHEEHAATGPH	FAM221B	331	A6H8Z2
SMARHSHVKHSPDFH	COX7B2	21	Q8TF08
GSSHHHHHQVPSMLR	ERC2	126	O15083
KHTDLDHECESIHPH	NLGN1	776	Q8N2Q7
HGEPRHLKECFHCHK	CHRNA6	386	Q15825
HPFHHHLLLAACMHS	DPH7	291	Q9BTV6
THSPESHPHLCKLHQ	FRMPD2B	261	Q6IN97
HSPESHPHLCKLHQE	FRMPD2	1251	Q68DX3
MLCHSHAFAPERRGH	CDH11	16	P55287
HRRCEYSHFMHHHRD	LYST	501	Q99698
RHCKPHHQFKESDCH	CLK4	41	Q9HAZ1
KRMVHFSPDSHHHDH	GPATCH2	376	Q9NW75
HSIISCHVEHHLFPR	FADS6	286	Q8N9I5
CHMHHHPGHVALSQT	INE1	21	O15225
SVMHRVARHAAPHVH	OR52K2	261	Q8NGK3
HQRPQMHRLQGHFHC	RPGRIP1	116	Q96KN7
ILHVHEKHRPHKCST	PRDM14	451	Q9GZV8
LHHHHDASCRQDFSP	NHS	726	Q6T4R5
RSQHPHATSCRHFHL	RNF165	26	Q6ZSG1
HDVMAHVHTFGHCCP	ADSL	86	P30566
IHSTPNCHDHERNHK	ARHGAP5	1021	Q13017
EHHEDHGIHESRRPC	SLF2	121	Q8IX21
HHAHRVLTHFFEREP	PM20D2	56	Q8IYS1
DVRHLPKKCPNHHHF	AKAP6	1956	Q13023
VELKHAASCHPMHRG	TOP3B	811	O95985
ARAARMLHHCRSHNP	RAPGEF3	846	O95398
SFHQPGHLRAHMRAH	ZNF516	1106	Q92618
HERVHSNERPFACHM	ZBTB14	351	O43829
HKFCLTNHHRMHTGE	ZNF880	391	Q6PDB4
ECHKVFSHNSHLARH	ZNF880	496	Q6PDB4
AEHRRVHTGEKPHAC	ZNF497	346	Q6ZNH5
PFHCPSAFHKHERTH	ZNF441	651	Q8N8Z8
AQHHKIHTGEKPHEC	ZNF250	271	P15622
EHHRTHTGERPYECH	ZNF135	231	P52742
FSRPDHLSCHVKHVH	VEZF1	241	Q14119
HLSCHVKHVHSTERP	VEZF1	246	Q14119
PVTSHRCHHKQKHCP	NEURL1	36	O76050
RHMCHFIEIHHHLGS	STYXL1	226	Q9Y6J8
HKMELRHLEDHQAHC	TRAF6	141	Q9Y4K3
HLHTHGPRVHVCAEC	YY1	316	P25490
EHGHHRACVHVYKVL	VPS18	706	Q9P253
MRKHLHIHGPRVHVC	YY2	271	O15391
HRRIHTGEKPHQCGH	ZNF696	311	Q9H7X3
IHEKIHTGERHHECT	ZNF585B	231	Q52M93
IESEPHQHHSLHTCL	USF3	261	Q68DE3
IRTEMPHCHHAHGRE	TECPR2	566	O15040
CGHPRHAVDAHLLHA	nan	51	Q5BKY6
RPCSPVHHHEGHAKL	USP20	391	Q9Y2K6
IHEKIHTGERHHECT	ZNF585A	231	Q6P3V2
HVCDITRRSHRHHEH	ZNF717	181	Q9BY31
SFCHGTPLHIHEKIH	ZNF180	281	Q9UJW8
PLPVESHLDHCMHDH	SNRNP200	1721	O75643
HIRHHDNIRPHKCSV	ZBTB17	576	Q13105
RHHRIHTGEKPFHCN	ZNF879	361	B4DU55
VKHRRVHTGESPHVC	ZNF792	326	Q3KQV3
HSHCFRTHERPHTRE	ZNF491	86	Q8N8L2
GHPLTLDHCLHHFIS	USP30	261	Q70CQ3
RKSHFTCHHRVHTGE	ZNF765	366	Q7L2R6
HGVRAVECRHHSCPM	ZNF142	311	P52746
AHHHRVHSGERPYQC	ZNF524	186	Q96C55
LSVPGHHHQKEMRRC	HIVEP2	1016	P31629
HSCLVVEHKEHRCRH	TRIM66	86	O15016
HVPLHFCSRFGHHDI	TNNI3K	236	Q59H18
HQKIHTGERHHVCSE	ZNF175	521	Q9Y473
SPRSCHRHERSHMGE	ZNF439	281	Q8NDP4
HSRDVAAIHCGHTFH	TRAIP	16	Q9BWF2
HRHVHTGERPHACGV	ZNF628	556	Q5EBL2
IHLHAHSLVGKHCED	NFKB1	106	P19838