Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

HNF1A POU4F1

2.46e-03275121.10.260.40
DomainLambda_DNA-bd_dom

HNF1A POU4F1

2.83e-0329512IPR010982
DomainHelicase_C

BTAF1 RAD54L2 SNRNP200

3.12e-03107513PF00271
DomainHELICc

BTAF1 RAD54L2 SNRNP200

3.12e-03107513SM00490
DomainHelicase_C

BTAF1 RAD54L2 SNRNP200

3.20e-03108513IPR001650
DomainHELICASE_CTER

BTAF1 RAD54L2 SNRNP200

3.29e-03109513PS51194
DomainHELICASE_ATP_BIND_1

BTAF1 RAD54L2 SNRNP200

3.29e-03109513PS51192
DomainDEXDc

BTAF1 RAD54L2 SNRNP200

3.29e-03109513SM00487
DomainHelicase_ATP-bd

BTAF1 RAD54L2 SNRNP200

3.37e-03110513IPR014001
DomainSNF2_N

BTAF1 RAD54L2

3.44e-0332512IPR000330
DomainSNF2_N

BTAF1 RAD54L2

3.44e-0332512PF00176
DomainAldolase_TIM

ALAD PRKAG2

6.43e-0344512IPR013785
Pubmed

The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma.

HNF1A MUC5AC

2.28e-06253221348892
Pubmed

GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

HNF1A MUC5AC

4.76e-05753222554936
Pubmed

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

OR2T27 OR2T35 OR2T7

4.84e-054653332126975
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NPHP3 FAM120A DIS3L MICAL3 SNRNP200 TBC1D9

1.03e-0449353615368895
Pubmed

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

HNF1A MICAL3 DRAM2

1.56e-046853322001757
Pubmed

Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity.

POU4F1 PCDH20

2.36e-041553230078709
Pubmed

Pten Regulates Retinal Amacrine Cell Number by Modulating Akt, Tgfβ, and Erk Signaling.

TGFBR2 POU4F1

3.43e-041853227605619
Pubmed

Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.

USP25 FAM47E

3.43e-041853221738487
Pubmed

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

ALDH1L2 ATG2B OR2T1 IFT46 MYEF2

4.42e-0441953533001583
Pubmed

Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.

TGFBR2 POU4F1

4.70e-042153217559664
Pubmed

Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons.

SKOR2 POU4F1

5.65e-042353235815619
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

UBE2J1 FAM120A BTAF1 TBC1D9

9.43e-0428553432838362
Pubmed

Joint influence of small-effect genetic variants on human longevity.

HNF1A PCDH20

1.24e-033453220834067
Pubmed

Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.

SKOR2 POU4F1

1.31e-033553238025786
Cytoband1q44

OR2T27 OR2T35 OR2T7 OR2T1

8.34e-061105341q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T27 OR2T35 OR2T7 OR2T1

1.52e-05128534chr1q44
CytobandEnsembl 112 genes in cytogenetic band chr9q32

C9orf43 ALAD

1.55e-0350532chr9q32
GeneFamilyOlfactory receptors, family 2

OR2T27 OR2T35 OR2T7 OR2T1

1.01e-04113394149
GeneFamilyLIM domain containing

NRAP MICAL3

7.18e-03593921218
ToppCellIPF-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

SNED1 MICAL3 DRAM2 PARP14 TBC1D9

2.87e-06187535af1327559f7e01bec070881cae52834917c3da65
ToppCellCTRL-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

SNED1 MICAL3 DRAM2 PARP14 TBC1D9

3.02e-0618953514f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCellTCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-7|TCGA-Cervix / Sample_Type by Project: Shred V9

HNF1A AKR7L FAM47E MUC5AC

3.84e-0515953475a82bbabd97b168dbf1c3f43a9bdad48ce18c78
ToppCellTCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

HNF1A AKR7L FAM47E MUC5AC

5.10e-051715341af575809b3334bfaa019ff26c56e6cb03c82ee8
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STARD9 IFT46 FAM47E MYEF2

5.22e-0517253473e9b29b1c6b8b016b495a0d20336d0c0761e5e2
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C9orf43 CYP2B6 NRAP MUC5AC

5.46e-0517453442f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C9orf43 CYP2B6 NRAP MUC5AC

5.46e-051745343f0a5ce074675d57d479fa069385a1b3071e884e
ToppCellfacs-Lung-24m-Endothelial-lymphatic_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 TGFBR2 SNED1 ENPP3

6.50e-051825340cde2775bdaaa2172499925bd59b0ac2d545eb27
ToppCellfacs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 TGFBR2 SNED1 ENPP3

6.50e-051825342cc434e46985c66fc36de05344a67aa96d90abc9
ToppCellfacs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 TGFBR2 SNED1 ENPP3

6.50e-051825343e7457b2a70b45735fb75d6617b7f34cef28758e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR2 SNED1 STARD9 CARD8

6.78e-05184534688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MICAL3 ALAD PARP14 TBC1D9

7.07e-0518653455b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCellControl-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

SNED1 MICAL3 DRAM2 TBC1D9

7.22e-051875344e64be635f445276e71f2937f33f041c3a4204ab
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

MAGI1 NRAP MICAL3 PRKAG2

7.52e-051895340a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 TGFBR2 SNED1 ENPP3

7.68e-05190534a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2B6 ANKRD36C PARP14 MUC5AC

7.68e-051905346ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

MAGI1 NRAP MICAL3 PRKAG2

7.68e-0519053493c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 TGFBR2 SNED1 ENPP3

7.68e-051905340bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCellCOPD-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

SNED1 MICAL3 PARP14 TBC1D9

7.68e-051905341e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI1 TGFBR2 SNED1 ENPP3

7.68e-0519053426e2237f65cb43723c5da853831b40df2982d6e4
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

MAGI1 NRAP MICAL3 PRKAG2

7.83e-051915345d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellfacs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 TGFBR2 SNED1 ENPP3

7.83e-0519153448823a97c38263f2c6e58348214f5b62773a6368
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 TGFBR2 SNED1 ENPP3

7.83e-051915340eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCellCF-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

SNED1 MICAL3 PARP14 TBC1D9

8.15e-051935347ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

MAGI1 NRAP MICAL3 PRKAG2

8.32e-05194534c3535f7cc0076653c72db582047cff053c322397
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

UBE2J1 MICAL3 DRAM2 TBC1D9

8.49e-051955346da69e3eba036936f44bc052996ad12b6309055e
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

MAGI1 MCTP1 PARP14 CARD8

8.49e-0519553450a193475db1bb1e05b8590225a553688c372c14
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP42 MAGI1 CYP2B6 PARP14

8.65e-05196534ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP42 CYP2B6 MCTP1 MUC5AC

8.65e-05196534b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP42 CYP2B6 MCTP1 MUC5AC

8.65e-05196534c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2B6 SAXO2 ANKRD36C MUC5AC

8.83e-051975345c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ENPP3 BTAF1 ANKRD36C SNRNP200

8.83e-0519753457ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UBE2J1 ALDH1L2 MICAL3 TBC1D9

8.83e-051975340f489d26e4013d1b5a90559856ed2de32a0bb772
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B|lymph-node_spleen / Manually curated celltypes from each tissue

MICAL3 DRAM2 PARP14 TBC1D9

9.00e-051985341780fa1725a321041094e8c4430673c0a4f3d407
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BTAF1 ANKRD36C PARP14 SNRNP200

9.18e-05199534f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TGFBR2 MCTP1 PARP14 DISP1

9.36e-05200534bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

TGFBR2 MCTP1 PARP14 DISP1

9.36e-05200534432384faeade8e609154fab3d96c955a8ec868dd
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TGFBR2 MCTP1 PARP14 DISP1

9.36e-0520053489821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TGFBR2 MCTP1 PARP14 DISP1

9.36e-0520053479e51afb57ca38aacebd0298e5e727b55c0cfff9
Diseasekidney disease (biomarker_via_orthology)

TGFBR2 HNF1A

5.79e-0421502DOID:557 (biomarker_via_orthology)
Diseaseintraocular pressure measurement

NPHP3 SCAMP1 DRAM2 PRKAG2 TNS1

1.67e-03509505EFO_0004695
DiseaseMastocytosis

ARHGAP42 CYP2B6

2.00e-0339502EFO_0009001
DiseaseDiabetic Nephropathy

TGFBR2 HNF1A

2.54e-0344502C0011881
DiseaseGastrointestinal Stromal Sarcoma

TGFBR2 DISP1

2.90e-0347502C3179349
Diseasemyocardial infarction

ARHGAP42 HNF1A DCLRE1B TNS1

2.92e-03350504EFO_0000612
Diseasepulmonary fibrosis (biomarker_via_orthology)

TGFBR2 MUC5AC

3.27e-0350502DOID:3770 (biomarker_via_orthology)
DiseaseGastrointestinal Stromal Tumors

TGFBR2 DISP1

3.27e-0350502C0238198

Protein segments in the cluster

PeptideGeneStartEntry
KQHTFPLESYKHEPE

PRKAG2

171

Q9UGJ0
ILSTALHDPHYFEKP

CYP2B6

391

P20813
YLHAPDHSAPVEETL

AKR7L

111

Q8NHP1
IIDSPKHGSIIYHPS

ALDH1L2

116

Q3SY69
KYPHLITKEPFEHES

RAD54L2

936

Q9Y4B4
IHSSHPDIHVIPYSD

DCLRE1B

261

Q9H816
YHLDPRGPKSELEHE

DISP1

1176

Q96F81
VPPHYTELLTFHSKE

ATG2B

621

Q96BY7
DHSHLFDSKDPPIYS

RBM12B

506

Q8IXT5
PPLFTHTVKDSDHIS

ANKRD36C

516

Q5JPF3
LVKVSDHGYPEPLHS

PCDH20

821

Q8N6Y1
TLPEHKYPSLHSSSE

POU4F1

16

Q01851
LPHSYHKPAQDKVLS

OR2T1

311

O43869
RALVHPKTHPVSEYE

MICAL3

201

Q7RTP6
YPQTDELHPKIHSVL

NMBR

201

P28336
TDVTLTLKDPHYPDH

MCTP1

356

Q6DN14
TLKDPHYPDHDLGII

MCTP1

361

Q6DN14
LESSYPPDLHKSSPH

MAGI1

1271

Q96QZ7
IKHHYTPTADLPEVL

NRAP

1001

Q86VF7
DKHPDLPLAVYHVSG

ALAD

266

P13716
VLPHSYHTPEQDKAV

OR2T7

251

P0C7T2
VTLHHIDPALPYISD

DRAM2

31

Q6UX65
LQSPHALYSHKPEVA

HNF1A

496

P20823
SSESSYKHHPALSPI

MUC5AC

31

P98088
IPHEGKHTPLYERSS

FAM120A

421

Q9NZB2
LPHSYHTPEQDKAVS

OR2T27

261

Q8NH04
LPHSYHTPEKDKVVS

OR2T35

261

Q8NGX2
LTPIGDKYDPHEHEL

GRPEL2

166

Q8TAA5
PTDLYDTVTDNVHHP

PARP14

1766

Q460N5
ISELHRSKPPATVHY

IFT46

186

Q9NQC8
EHDLLKPHLPSVTYL

BTAF1

1661

O14981
HLLKVPFYEPSHAEE

ENPP3

541

O14638
ESQESHGKEYPEHLP

DIS3L

216

Q8TF46
HHSVKSPELYETEPT

C9orf43

386

Q8TAL5
HPEDIKFHLYLVPSD

CARD8

326

Q9Y2G2
HTDFTPSPYDHDSLK

SASH3

181

O75995
EDVEAHLTPHPLALY

FAM47E

116

Q6ZV65
SVPHEEYRSHDGKTP

MYEF2

311

Q9P2K5
PDHPSLAYTVKHLAI

NPHP3

1171

Q7Z494
EHYEKIFHTAPDPSI

ARHGAP42

566

A6NI28
TLETVCHDPKLPYHD

TGFBR2

96

P37173
SSDPSYNKEKHIIHP

SECISBP2

346

Q96T21
PTEEHPAYTQIAKEH

SCAMP1

66

O15126
LSPDSHYPLEEEKTD

STARD9

1686

Q9P2P6
HSEPAHLYIITSPRD

SNED1

1186

Q8TER0
PKEPHLHSYKEAFEE

TNS1

941

Q9HBL0
IPHLHSLLSDDVEPY

TBC1D9

751

Q6ZT07
SFHEPPKLPSYSTHE

USP25

1021

Q9UHP3
ELKDPTDHYHAQPLE

UBE2J1

21

Q9Y385
SHYVPHELIPTESCK

SAXO2

321

Q658L1
SPVHHPSLEEQPSYK

SKOR2

856

Q2VWA4
KFLYEPLPVESHLDH

SNRNP200

1716

O75643
EEYKEVEEHPPLSSS

ZNF852

131

Q6ZMS4
SPDGHPYEKIHTAEK

ZNF239

191

Q16600