Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Aminotransferase_I/II	ALAS1 GPT2	1.29e-03	17	59	2	IPR004839
Domain	Aminotran_1_2	ALAS1 GPT2	1.29e-03	17	59	2	PF00155
Domain	C2_dom	RPGRIP1 GAK CPNE5 RASAL1	1.79e-03	164	59	4	IPR000008
Domain	-	ATR TTC39C GPS1 COA7	4.14e-03	207	59	4	1.25.40.10
Domain	-	ALAS1 GPT2	5.46e-03	35	59	2	3.90.1150.10
Domain	PyrdxlP-dep_Trfase_major_sub2	ALAS1 GPT2	5.77e-03	36	59	2	IPR015422
Domain	TPR-like_helical_dom	ATR TTC39C GPS1 COA7	6.28e-03	233	59	4	IPR011990
Domain	-	ALAS1 GPT2	6.74e-03	39	59	2	3.40.640.10
Domain	PyrdxlP-dep_Trfase	ALAS1 GPT2	7.43e-03	41	59	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	ALAS1 GPT2	7.43e-03	41	59	2	IPR015421
Domain	C2	RPGRIP1 CPNE5 RASAL1	8.24e-03	131	59	3	PF00168
Domain	C2	RPGRIP1 CPNE5 RASAL1	9.30e-03	137	59	3	SM00239
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FLNB PDE3A NCKAP1 AP1G1 HNRNPUL2 UBE3A CLNS1A GPS1 NT5C2 MTR NIBAN2 TSEN2 TNPO3 RASAL1	1.68e-07	1455	61	14	22863883
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	FLNB MAP2K4 MYL3 OTULIN UBE3A PATZ1 TBC1D5 GPS1	1.96e-06	481	61	8	28190767
Pubmed	The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis.	GABRD GPT2	3.03e-06	2	61	2	36923530
Pubmed	The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation.	ATR PIEZO1	9.07e-06	3	61	2	34158506
Pubmed	Intermediate phenotypes identify divergent pathways to Alzheimer's disease.	RGSL1 IL1A BDNF	1.15e-05	25	61	3	20574532
Pubmed	Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.	NT5C2 BDNF	1.81e-05	4	61	2	35295960
Pubmed	Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.	FLNB FZD3 BDNF	2.02e-05	30	61	3	19054571
Pubmed	Developmental regulation of myosin gene expression in mouse cardiac muscle.	MYH7 MYL3	3.02e-05	5	61	2	2277065
Pubmed	Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining.	LIG3 ATR	3.02e-05	5	61	2	27806302
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TRPM3 CPNE5 DNAH5 KNL1	3.08e-05	101	61	4	10997877
Pubmed	The genetics of Alzheimer's disease in Brazil: 10 years of analysis in a unique population.	IL1A BDNF	4.52e-05	6	61	2	18607773
Pubmed	A spastic paraplegia mouse model reveals REEP1-dependent ER shaping.	AP1G1 TIMM23B	4.52e-05	6	61	2	24051375
Pubmed	LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase.	MAP2K4 SCARB1	4.52e-05	6	61	2	18757346
Pubmed	Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy.	MYH7 MYL3	4.52e-05	6	61	2	12707239
Pubmed	Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease.	MTR IL1A	6.32e-05	7	61	2	15201366
Pubmed	Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling.	MYH7 MYL3	6.32e-05	7	61	2	16199542
Pubmed	Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations.	MYH7 MYL3	8.42e-05	8	61	2	20359594
Pubmed	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	FZD3 IL1A BDNF	1.07e-04	52	61	3	18583979
Pubmed	Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.	MYH7 MYL3	1.08e-04	9	61	2	16754800
Pubmed	ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.	FLNB MAP2K4	1.08e-04	9	61	2	19270716
Pubmed	The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy.	MYH7 MYL3	1.08e-04	9	61	2	19293840
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	FLNB NT5C2 DNAH5 COA7 KNL1	1.28e-04	277	61	5	30745168
Pubmed	The expression of myosin genes in developing skeletal muscle in the mouse embryo.	MYH7 MYL3	1.35e-04	10	61	2	2211821
Pubmed	Shared genetic causes of cardiac hypertrophy in children and adults.	MYH7 MYL3	1.35e-04	10	61	2	18403758
Pubmed	Suppression of atrial myosin gene expression occurs independently in the left and right ventricles of the developing mouse heart.	MYH7 MYL3	1.35e-04	10	61	2	10679931
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	LIG3 ATR AP1G1 HNRNPUL2 TBC1D5 MTR CEMIP	1.40e-04	650	61	7	38777146
Pubmed	Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.	LIG3 ATR	1.65e-04	11	61	2	15758953
Pubmed	The FgfrL1 receptor is required for development of slow muscle fibers.	MYH7 MYL3	1.65e-04	11	61	2	25172430
Pubmed	Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy.	MYH7 MYL3	1.65e-04	11	61	2	20031618
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	MYL3 NCKAP1 AP1G1 UBE3A GPT2	1.97e-04	304	61	5	32235678
Pubmed	Influence of ethanol on thermoregulation: mapping quantitative trait loci.	SCN4A IL1A	1.97e-04	12	61	2	11773602
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH7 MYL3	2.33e-04	13	61	2	8404542
Pubmed	Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy.	MYH7 MYL3	2.33e-04	13	61	2	18513529
Pubmed	Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations.	MYH7 MYL3	2.33e-04	13	61	2	19853701
Pubmed	Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.	MYH7 MYL3	2.33e-04	13	61	2	7628699
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAP2K4 NCKAP1 HNRNPUL2 UBE3A PATZ1 TBC1D5 NT5C2 RASAL1	2.70e-04	963	61	8	28671696
Pubmed	Functional domains of the FgfrL1 receptor.	MYH7 MYL3	2.72e-04	14	61	2	31923383
Pubmed	Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.	MYH7 MYL3	3.13e-04	15	61	2	17468400
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	GAK ATR ALAS1 CHM	3.26e-04	186	61	4	33637726
Pubmed	No replication of genetic association between candidate polymorphisms and Alzheimer's disease.	IL1A BDNF	3.57e-04	16	61	2	19889475
Pubmed	Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	ATR KNL1	3.57e-04	16	61	2	20301772
Pubmed	YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB.	OTULIN UBE3A	3.57e-04	16	61	2	28244869
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	LIG3 CYP2C18 ATR MTR IL1A	3.81e-04	351	61	5	20453000
Pubmed	Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.	IL1A BDNF	4.05e-04	17	61	2	20413850
Pubmed	Agrin has a pathological role in the progression of oral cancer.	FLNB MYH7 MYL3 HNRNPUL2	4.05e-04	197	61	4	29872149
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	LIG3 FLNB MAP2K4 GAK UBE3A	4.27e-04	360	61	5	33111431
Pubmed	Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.	TRPM3 BDNF	4.55e-04	18	61	2	31911949
Pubmed	Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.	MYH7 MYL3	5.08e-04	19	61	2	22589735
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTULIN UBE3A	5.08e-04	19	61	2	23827681
Pubmed	Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.	LIG3 ATR	5.63e-04	20	61	2	16195237
Pubmed	Functional proteomics mapping of a human signaling pathway.	FLNB AP1G1 UBE3A NIBAN2 TNPO3 KNL1	5.90e-04	591	61	6	15231748
Pubmed	Myocardial Mycn is essential for mouse ventricular wall morphogenesis.	MYH7 MYL3	6.22e-04	21	61	2	23063798
Pubmed	An Alternative Splicing Program for Mouse Craniofacial Development.	FLNB SCARB1	6.22e-04	21	61	2	33013468
Pubmed	Gene-environment interaction impacts on heart development and embryo survival.	MYH7 MYL3	6.83e-04	22	61	2	30787001
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNB PDE3A DNAH5 TNPO3	7.72e-04	234	61	4	36243803
Pubmed	The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.	MYH7 MYL3	8.15e-04	24	61	2	10021345
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	FLNB MAP2K4 NCKAP1 HNRNPUL2 UBE3A PDK2 RASAL1 TBC1D24	8.16e-04	1139	61	8	36417873
Pubmed	A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.	ATR IL1A TBC1D24	8.47e-04	105	61	3	23284306
Pubmed	DNA segments mapped by reciprocal use of microsatellite primers between mouse and rat.	MYL3 IL1A	8.84e-04	25	61	2	8268655
Pubmed	GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.	CYP2C18 PDK2	8.84e-04	25	61	2	32913122
Pubmed	Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.	LIG3 ATR	9.57e-04	26	61	2	20731661
Pubmed	Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.	MYH7 MYL3	9.57e-04	26	61	2	11238910
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MAP2K4 MYH7 GAK ATR NCKAP1 STK33 KNL1	1.05e-03	910	61	7	36736316
Pubmed	Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.	LIG3 IL1A	1.11e-03	28	61	2	19661089
Pubmed	Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.	IL1A BDNF	1.11e-03	28	61	2	20534741
Pubmed	Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.	NT5C2 BDNF	1.11e-03	28	61	2	24861553
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	TRPM3 RBAK IL1A IL2RA	1.22e-03	265	61	4	19240061
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	RGSL1 HNRNPUL2 TBC1D5 STK33 RBAK RXFP1	1.27e-03	686	61	6	29987050
Pubmed	Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.	LIG3 GPS1	1.28e-03	30	61	2	24292625
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH7 MYL3	1.54e-03	33	61	2	32094117
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	RPGRIP1 GAK TBC1D5 NT5C2 ALAS1	1.59e-03	483	61	5	27107014
Pubmed	Hypertrophic Cardiomyopathy Overview	MYH7 MYL3	1.64e-03	34	61	2	20301725
Pubmed	Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.	MYH7 MYL3	1.64e-03	34	61	2	31024170
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	FZD3 SCARB1	1.73e-03	35	61	2	30940800
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GABRD MYH7 RGSL1 CPNE5 RASAL1	2.79e-06	161	61	5	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	COVID-19-Heart-CM_4\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A MYL3 C1orf105 CPNE5 BDNF	5.21e-06	183	61	5	2902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH7 PDE3A MYL3 CPNE5 BDNF	5.35e-06	184	61	5	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH7 PDE3A MYL3 CPNE5 BDNF	5.50e-06	185	61	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB PDE3A CLNS1A ALAS1 SLC2A13	5.50e-06	185	61	5	87151ab95530e70d61328b336518df58db584acb
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 PIEZO1 STK33 MTR RASAL1	6.10e-06	189	61	5	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A TRPM3 TTC39C SLC2A13 CEMIP	7.10e-06	195	61	5	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	Bronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_systemic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A MYL3 SCN4A SYPL2 BDNF	7.83e-06	199	61	5	78a9b26215874a46a910a4b93a51fcac1a597618
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPGRIP1 IL1A CPNE5 KNL1	6.22e-05	156	61	4	203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 ACTRT3 FAXC CPNE5	7.92e-05	166	61	4	548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 ACTRT3 FAXC CPNE5	7.92e-05	166	61	4	80e164a89d22098cabe4a99a78283ba69ea0561e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5_RORB_LINC01202\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 DNAH5 BDNF CEMIP	8.68e-05	170	61	4	87cac555f16b6c2ef3d1b3a00f992d8bf2237b50
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGSL1 TRPM3 IL2RA TBC1D24	8.68e-05	170	61	4	2b5b1f8d13b9806b76b44a53f47a23dd9ff09808
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGSL1 TRPM3 IL2RA TBC1D24	8.68e-05	170	61	4	43c48267d8291c88263148a36fbb63c27f0e4f1c
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	TRPM3 STK33 MEGF11 RASAL1	9.92e-05	176	61	4	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRPM3 IL1A BDNF RASAL1	1.06e-04	179	61	4	7aa4137f672dadb3be92009cde6e0ea60a15372d
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARL16 NCKAP1 CHM COA7	1.11e-04	181	61	4	41969fe4d94ee77b12ecde32170aaf0b13e49644
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARL16 NCKAP1 CHM COA7	1.11e-04	181	61	4	3f50e61dc2a52d71a5801584617607e6246adcf2
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRD MYH7 SLC2A13 CPNE5	1.13e-04	182	61	4	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRD MYH7 SLC2A13 CPNE5	1.13e-04	182	61	4	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 MYL3 PDK2 CPNE5	1.13e-04	182	61	4	c4a7007c864a9455a7e7447e28ccd380878a6a0f
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 MYL3 PDK2 CPNE5	1.13e-04	182	61	4	c315d820ffad912c014ba5eac6f5fa6de1a94384
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	MYH7 PDE3A MYL3 BDNF	1.20e-04	185	61	4	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A MYL3 RXFP1 CEMIP	1.20e-04	185	61	4	5a0340c25196453f19e424d346efbf66d2c53ac3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 STK33 MTR RASAL1	1.20e-04	185	61	4	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FLNB TBC1D5 MTR GPT2	1.25e-04	187	61	4	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 MYL3 MTR CHM	1.28e-04	188	61	4	ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCell	ASK452-Immune-Mast_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	PDE3A ALAS1 CPNE5 IL2RA	1.28e-04	188	61	4	840215e16cff90f821f776186284eafcf2350690
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 STK33 ALAS1 RASAL1	1.28e-04	188	61	4	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	MYH7 MYL3 STK33 BDNF	1.28e-04	188	61	4	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH7 MYL3 MTR CHM	1.28e-04	188	61	4	40ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	MYH7 PDE3A MYL3 STK33	1.31e-04	189	61	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 STK33 MTR RASAL1	1.31e-04	189	61	4	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	MYH7 PDE3A CPNE5 BDNF	1.31e-04	189	61	4	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM3 STK33 ALAS1 RASAL1	1.33e-04	190	61	4	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	MYH7 PDE3A CPNE5 BDNF	1.33e-04	190	61	4	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH7 PDE3A MYL3 BDNF	1.33e-04	190	61	4	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A TTC39C SLC2A13 CEMIP	1.33e-04	190	61	4	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB PDE3A CYP2C18 SCN4A	1.33e-04	190	61	4	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	MYH7 PDE3A STK33 CPNE5	1.33e-04	190	61	4	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A TRPM3 TTC39C CEMIP	1.39e-04	192	61	4	25460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 STK33 MTR RASAL1	1.44e-04	194	61	4	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 STK33 MTR RASAL1	1.44e-04	194	61	4	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Basal_3\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	FSIP2 MYL3 BDNF CEMIP	1.53e-04	197	61	4	2cff37f9d33951840a8f52ccbba6ca1a4bbe3ad9
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_3\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FSIP2 MYL3 BDNF CEMIP	1.53e-04	197	61	4	4f8f23b1ef2eae9d300bd2c1a5cb7ef0163858a1
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FSIP2 ACTRT3 GPT2 BDNF	1.53e-04	197	61	4	f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FSIP2 MYL3 BDNF CEMIP	1.53e-04	197	61	4	0f37afad46b94c748a149d9ee681472d7a3e6937
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYH7 TTC39C IL2RA RASAL1	1.56e-04	198	61	4	b2c8d5956f8449df4b69fb1b30632253440f815e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Mesoderm\|3m / Sample Type, Dataset, Time_group, and Cell type.	MYH7 MYL3 C1orf105 SYPL2	1.62e-04	200	61	4	538ae964db58c4acafe93f735b3e03fc08fdaac6
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_2-C1R-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RXFP1 DNAH5 BDNF CEMIP	1.62e-04	200	61	4	891a80cbde575f81f3466217175f41e1d4f66d5e
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_2-C1R\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RXFP1 DNAH5 BDNF CEMIP	1.62e-04	200	61	4	c761d1742653a83e69e4c03d6e10e5e53f28bebb
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_2-C1R--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RXFP1 DNAH5 BDNF CEMIP	1.62e-04	200	61	4	dcbc91ed3351bafd72cf71d7025cbbdc8361d9b9
Computational	Genes in the cancer module 202.	FLNB MYH7 MYL3	1.36e-04	28	39	3	MODULE_202
Disease	Strabismus	RPGRIP1 GPT2 DNAH5	2.41e-05	29	57	3	HP_0000486
Disease	pancreatic cancer (is_implicated_in)	LIG3 MAP2K4 ATR MTR	6.65e-05	112	57	4	DOID:1793 (is_implicated_in)
Disease	myopathy (implicated_via_orthology)	FLNB MYH7 MEGF11	1.11e-04	48	57	3	DOID:423 (implicated_via_orthology)
Disease	Cardiomyopathies	MYH7 MYL3 PDK2 IL1A	1.19e-04	130	57	4	C0878544
Disease	Muscular dystrophy, limb-girdle, autosomal dominant	MYH7 TNPO3	1.63e-04	10	57	2	cv:C5675009
Disease	aspartate aminotransferase measurement	FLNB PDE3A TRPM3 TBC1D5 PIEZO1 SCARB1 STK33 BDNF	3.29e-04	904	57	8	EFO_0004736
Disease	Primary familial hypertrophic cardiomyopathy	MYH7 MYL3	8.26e-04	22	57	2	cv:C0949658
Disease	obsolete_red blood cell distribution width	CYP2C18 ATR PATZ1 TBC1D5 PIEZO1 SCARB1 C1orf105 NT5C2 KNL1	1.04e-03	1347	57	9	EFO_0005192
Disease	Limb-girdle muscular dystrophy	MYH7 TNPO3	1.16e-03	26	57	2	cv:C0686353
Disease	Intellectual Disability	TRPM3 NT5C2 GPT2 TSEN2 BDNF	1.71e-03	447	57	5	C3714756
Disease	Large cell carcinoma of lung	ATR STK33	1.75e-03	32	57	2	C0345958
Disease	Squamous cell carcinoma of lung	MAP2K4 ATR	1.75e-03	32	57	2	C0149782
Disease	Alcoholic Intoxication	MTR BDNF	1.75e-03	32	57	2	C0001969

Protein segments in the cluster

Peptide	Gene	Start	Entry
APDMFYCMKLLEETG	GPT2	461	Q8TD30
SYFGCMKAAPMKEAN	BDNF	11	P23560
LAMEKIKCFGFDMDY	NT5C2	41	P49902
CYVAMNYEEEMAKKP	ACTRT3	216	Q9BYD9
IDLPCYMSTEEMKSL	ARL16	141	Q0P5N6
KMCKMITEDSYPGYI	CEMIP	646	Q8WUJ3
ICMELMSTSFDKFYK	MAP2K4	176	P45985
MKFLTFCMEYEKYPD	CHM	296	P24386
EEKKYMELDPCKMDL	RASAL1	376	O95294
EECMFPKATDMTFKA	MYH7	536	P12883
AYHPLKMQSCYEKME	NIBAN2	396	Q96TA1
MMKELLYFLDSCEPE	AP1G1	381	O43747
SPFCLKMETYLRMAD	FAXC	116	Q5TGI0
SVMAFDCYMAISKPL	OR4D11	116	Q8NGI4
MAKVPDMFEDLKNCY	IL1A	1	P01583
IMDKGFKDYMKESVC	MEGF11	916	A6BM72
FTLAKMMPGCEIYSD	ALAS1	321	P13196
EAFMLFDRTPKCEMK	MYL3	56	P08590
KKYLMSSDFNEMSTC	FSIP2	4166	Q5CZC0
YKDTSSTPDCKNMMS	FSIP2	5446	Q5CZC0
MCDDEDIKDSPYMAF	FLNB	621	O75369
CSTYAPETMMFLDKP	PDE3A	656	Q14432
SKYASCLKMLDEMKD	GPS1	336	Q13098
EMKANFSLPEKCDYM	HNRNPUL2	591	Q1KMD3
AKMYCNPDAMSSLTE	KNL1	486	Q8NG31
TVACDMDLAKYPMDE	GABRD	161	O14764
SVEYAMKKCPNGMFS	LIG3	491	P49916
MKKCPNGMFSEIKYD	LIG3	496	P49916
DTMPCEYLSLDAMEK	NCKAP1	246	Q9Y2A7
DMAKLLCDKYYMASP	PDK2	206	Q15119
FSCDMAVPKNKMESD	PATZ1	586	Q9HBE1
SVAPEMDIMDYCKKE	OTULIN	81	Q96BN8
TAEAAVYMFSMKRCP	GAK	531	O14976
FYIMMCKPKDDLRKD	ATR	2321	Q13535
PSDKSALEAMFTAMC	CLNS1A	116	P54105
FKAMAYKEGTMLNCE	IL2RA	36	P01589
AYSECSKLMEMFGVP	FZD3	106	Q9NPG1
KSDYFMPFSAGKRMC	CYP2C18	421	P33260
DKDMFSKSDPLCVMY	CPNE5	36	Q9HCH3
KGFMSKYDPECHMIK	DNAH5	2601	Q8TE73
MLDPDCGFCYKMNKS	SLC2A13	446	Q96QE2
YEMPLCDEESSSKTM	SYPL2	91	Q5VXT5
CYLIKPSTMTDKEME	TSEN2	421	Q8NCE0
KMSFEELCYKNPKMA	RGSL1	576	A5PLK6
MSQKYPKADSEKMCI	RPGRIP1	1106	Q96KN7
VFETPKKMYLVMELC	STK33	181	Q9BYT3
MEEKFMAANPSKVSY	SCN4A	1701	P35499
DYDETPSMMAKHLKD	MTR	296	Q99707
SPEACRSMKLMYKES	SCARB1	276	Q8WTV0
LKMKSPLCTFYFSNM	MT-ND5	511	P03915
DDPKASFENCMSYRM	C1orf105	101	O95561
KDMDLACKYSMKACD	COA7	166	Q96BR5
MDSPGYNCFVDKDKM	TBC1D24	1	Q9ULP9
MVDEPPAMCSYFTKD	ZNF431	101	Q8TF32
YLEMALPLFCKAMSK	UBE3A	301	Q05086
LSLEFKNKDDMPYMS	TRPM3	811	Q9HCF6
MEMKPFECSECGKSF	RBAK	256	Q9NYW8
ELMKPDLFTYPCEMS	RXFP1	731	Q9HBX9
MLYKCTVSEMALDSP	TIMM23B	166	Q5SRD1
DVESCYFAAQTMKMK	TNPO3	56	Q9Y5L0
CGSMPYDDSNIKKML	TSSK1B	211	Q9BXA7
LVCTVKGYYDPKEMM	PIEZO1	1256	Q92508
DLDAMCKYCAKVMDT	TBC1D5	601	Q92609
SLMYASESKDMKAPL	TTC39C	256	Q8N584