Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Phosphofurin_acidic_CS-1	PACS2 PACS1	3.61e-06	2	36	2	IPR019381
Domain	Pacs-1	PACS2 PACS1	3.61e-06	2	36	2	PF10254
Domain	fn3	EPHB6 NEO1 IGF1R CNTN6	2.59e-04	162	36	4	PF00041
Domain	FN3	EPHB6 NEO1 IGF1R CNTN6	4.28e-04	185	36	4	SM00060
Domain	FN3	EPHB6 NEO1 IGF1R CNTN6	5.64e-04	199	36	4	PS50853
Domain	FN3_dom	EPHB6 NEO1 IGF1R CNTN6	6.78e-04	209	36	4	IPR003961
Domain	Prot_kinase_dom	EPHB6 STK36 MYO3A IGF1R	1.41e-02	489	36	4	IPR000719
Domain	PROTEIN_KINASE_DOM	EPHB6 STK36 MYO3A IGF1R	1.45e-02	493	36	4	PS50011
Pubmed	An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.	PACS2 PACS1	1.16e-06	2	38	2	22496420
Pubmed	Caught in the act - protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease.	PACS2 PACS1	1.16e-06	2	38	2	28476937
Pubmed	Functional connection between Rad51 and PML in homology-directed repair.	RAD51 PML	1.16e-06	2	38	2	21998700
Pubmed	Coloboma may be a shared feature in a spectrum of disorders caused by mutations in the WDR37-PACS1-PACS2 axis.	PACS2 PACS1	3.48e-06	3	38	2	33369122
Pubmed	RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice.	PACS2 PACS1	6.96e-06	4	38	2	36747781
Pubmed	Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.	RAD51 IGF1R	6.96e-06	4	38	2	14559999
Pubmed	Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis.	IGF1R TEP1	6.96e-06	4	38	2	18938767
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	PACS2 PACS1 SARS1 AKAP1 RPL15 XPO7	1.02e-05	462	38	6	31138677
Pubmed	Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1.	RAD51 PML	1.16e-05	5	38	2	22641345
Pubmed	Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.	NCOR1 PML	1.16e-05	5	38	2	10882117
Pubmed	WDR37 syndrome: identification of a distinct new cluster of disease-associated variants and functional analyses of mutant proteins.	PACS2 PACS1	1.74e-05	6	38	2	34642815
Pubmed	PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair.	RAD51 PML	1.74e-05	6	38	2	31009828
Pubmed	Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.	PACS2 PACS1	1.74e-05	6	38	2	15692563
Pubmed	Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.	NCOR1 IGF1R	2.43e-05	7	38	2	29523594
Pubmed	Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.	NCOR1 PML	3.24e-05	8	38	2	11430826
Pubmed	HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.	PACS2 PACS1	4.16e-05	9	38	2	18296443
Pubmed	RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.	RAD51 FGF6	4.16e-05	9	38	2	9192668
Pubmed	Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.	NCOR1 IGF1R	5.20e-05	10	38	2	24051437
Pubmed	Maturation of the HIV reverse transcription complex: putting the jigsaw together.	AKAP1 PML	5.20e-05	10	38	2	19750561
Pubmed	TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair.	RAD51 PML	6.35e-05	11	38	2	35061896
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RAD51 NCOR1 CRYBG3 AKAP1 BCORL1	8.87e-05	418	38	5	34709266
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	NEO1 CRYBG3 SARS1 AKAP1 CSPP1 RPL15 PML POP1	1.70e-04	1487	38	8	33957083
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PACS2 PACS1 NCOR1 MYO3A AKAP1 POP1	1.79e-04	774	38	6	15302935
Pubmed	Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.	RPL15 POP1	2.41e-04	21	38	2	21509594
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HAUS8 IGF1R CRYBG3 AKAP1 CSPP1 PML	3.18e-04	861	38	6	36931259
Pubmed	Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.	DOK6 FGF6	4.32e-04	28	38	2	24483146
Pubmed	S100A3 a partner protein regulating the stability/activity of RARα and PML-RARα in cellular models of breast/lung cancer and acute myeloid leukemia.	NCOR1 PML	5.65e-04	32	38	2	30532072
Pubmed	alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.	RAD51 PML	6.38e-04	34	38	2	16889989
Pubmed	Joubert Syndrome	CPLANE1 CSPP1	6.38e-04	34	38	2	20301500
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	NCOR1 LCOR	6.76e-04	35	38	2	19389355
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	RAD51 STK36 IGF1R PML	7.06e-04	371	38	4	25241761
Pubmed	Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.	NEO1 PML	7.56e-04	37	38	2	16707424
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	RAD51 NCOR1 IGF1R	8.54e-04	170	38	3	19064572
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	NCOR1 IGF1R LCOR RPL15 BCORL1	8.79e-04	689	38	5	36543142
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	EPHB6 IGF1R	8.83e-04	40	38	2	30898150
Interaction	CEP43 interactions	HAUS8 PACS1 NCOR1 CRYBG3 AKAP1 CSPP1	1.39e-06	190	38	6	int:CEP43
Cytoband	Ensembl 112 genes in cytogenetic band chr15q24	NEO1 PML	4.63e-03	122	38	2	chr15q24
Cytoband	Ensembl 112 genes in cytogenetic band chr10p12	MYO3A SKIDA1	6.04e-03	140	38	2	chr10p12
GeneFamily	Fibronectin type III domain containing	EPHB6 NEO1 IGF1R CNTN6	7.59e-05	160	26	4	555
Coexpression	SHIN_B_CELL_LYMPHOMA_CLUSTER_7	IGF1R TEP1 PML	8.03e-06	27	38	3	M1391
Coexpression	SHIN_B_CELL_LYMPHOMA_CLUSTER_7	IGF1R TEP1 PML	8.03e-06	27	38	3	MM1135
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN	ZNF708 ZNF567 IGF1R PIGA LCOR STXBP5 ERMN	4.81e-05	680	38	7	M41089
Coexpression	MURARO_PANCREAS_BETA_CELL	MYO3A NEO1 IGF1R PIGA SARS1 MTERF2 STXBP5 NEXMIF	5.22e-05	946	38	8	M39169
Coexpression	FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN	RAD51 STK36 IGF1R CPLANE1 TEP1 FRMD7 PML	8.60e-05	746	38	7	M40863
Drug	Tin chromate	PACS2 STK36 IGF1R	3.44e-06	18	38	3	CID000061472
Drug	stannous ion	PACS2 STK36 IGF1R	5.59e-06	21	38	3	CID000104883
Drug	iridium	EPHB6 PACS2 STK36 IGF1R	8.61e-06	78	38	4	CID000023924
Drug	Diazoxide [364-98-7]; Up 200; 17.4uM; MCF7; HT_HG-U133A	RAD51 EPHB6 PACS1 NCOR1 TEP1	1.83e-05	197	38	5	7168_UP
Disease	Joubert syndrome 1	CPLANE1 CSPP1	2.67e-04	21	34	2	C4551568
Disease	Glioblastoma Multiforme	EPHB6 NCOR1 PML	2.85e-04	111	34	3	C1621958
Disease	Ovarian Serous Adenocarcinoma	STK36 MYO3A	3.21e-04	23	34	2	C1335177
Disease	Familial aplasia of the vermis	CPLANE1 CSPP1	5.49e-04	30	34	2	C0431399
Disease	Ovarian Mucinous Adenocarcinoma	EPHB6 MYO3A	5.87e-04	31	34	2	C1335167
Disease	Malignant neoplasm of breast	RAD51 NCOR1 IGF1R CNTN6 BCORL1 POP1	1.29e-03	1074	34	6	C0006142
Disease	caudate nucleus measurement, functional brain measurement, response to reward	DOK6 CNTN6	1.35e-03	47	34	2	EFO_0007849, EFO_0008387, EFO_0008396
Disease	cytokine measurement	PACS1 IGF1R CNTN6 ACOXL	1.88e-03	461	34	4	EFO_0004873

Protein segments in the cluster

Peptide	Gene	Start	Entry
YGGYKRVKVDVLRQI	AKAP1	796	Q92667
TYRGPRHIGKYLKQQ	CRYBG3	231	Q68DQ2
SGYLVGIKRQRRLYC	FGF6	76	P10767
KRRRQKSRKYQTGEY	BCORL1	1331	Q5H9F3
LQRGLVARIYYKVKT	ACOXL	446	Q9NUZ1
YLRKGRGETRICKIY	RAD51	301	Q06609
YSGRTQRQLLEYGRK	FRMD7	301	Q6ZUT3
SRQEYRKYGGAKLNR	IGF1R	881	P08069
SKQPRKKRGRYRQYN	LCOR	336	Q96JN0
YRRYLTQGITQGKRK	CSPP1	131	Q1MSJ5
GLVYLRLGRATQNYK	LCN10	126	Q6JVE6
QRRKRYKNRTILGYK	PACS2	116	Q86VP3
SRYNTISYRKIRKGN	ERMN	256	Q8TAM6
GGRVIESRYLQYEKK	HAUS8	31	Q9BT25
RRKRYKNRTILGYKT	PACS1	196	Q6VY07
QYRIRKLNSSGYRIK	MTERF2	331	Q49AM1
GKRQGSLVLYRVNKY	POP1	286	Q99575
YSNYLLRKQKRRGGA	GAL3ST3	391	Q96A11
LRLYLYVSGNGKRIV	CPLANE1	116	Q9H799
QGYVKIRSRKLGIFR	DOK6	11	Q6PKX4
LGYKILYRQNRQSKT	CNTN6	936	Q9UQ52
YQARRLRIRYGQTKK	SARS1	401	P49591
QNYGLRAKRKVRYSE	NEXMIF	476	Q5QGS0
RQGGLKKYSRYLSLQ	PML	816	P29590
RKRRGTGYTEQLQQY	EPHB6	621	O15197
NYKALVRRNYGKRRG	NCOR1	486	O75376
TQNGQITGYKIRYRK	NEO1	661	Q92859
YKFGARVRKNYRTLV	SKIDA1	771	Q1XH10
LYSVGARQKRQGYSK	STXBP5	416	Q5T5C0
GRVYKGRRKYSAQVV	STK36	16	Q9NRP7
NRKGIRYLTSGLKVY	PIGA	76	P37287
RKRLSEYNGYGKSLL	ZNF567	156	Q8N184
KSYLSRQKGITCRRY	TEP1	1061	Q99973
KQGYVIYRIRVRRGG	RPL15	56	P61313
QQVILRRYGKCGYQK	ZNF708	96	P17019
YIGDQVQKSSKLYRR	XPO7	561	Q9UIA9
YSIYRKGTKAQRRNV	ZNF22-AS1	91	Q5T742
VFIQSKYRGYKRRQQ	MYO3A	1351	Q8NEV4