Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPM2 GRIN2A RYR2 TPCN1

2.04e-05311054GO:0099604
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

TRPM2 GRIN2A RYR2 TPCN1 SCNN1A TMEM63A

9.72e-051401056GO:0099094
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TRPM2 RYR2 TPCN1

1.09e-04181053GO:0015278
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPM2 CACHD1 GRIN2A RYR2 TPCN1 SLC8A1

1.47e-041511056GO:0015085
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

TRPM2 GRIN2A RYR2 TPCN1 SCNN1A TMEM63A

5.49e-041931056GO:0015276
GeneOntologyMolecularFunctioncalcium channel activity

TRPM2 CACHD1 GRIN2A RYR2 TPCN1

6.00e-041291055GO:0005262
GeneOntologyMolecularFunctionligand-gated channel activity

TRPM2 GRIN2A RYR2 TPCN1 SCNN1A TMEM63A

6.12e-041971056GO:0022834
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TRPM2 RYR2 TPCN1

6.87e-04331053GO:0005217
GeneOntologyBiologicalProcessextension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

SRGAP2 SRGAP2C

2.57e-0521052GO:0021816
GeneOntologyBiologicalProcessmanganese ion transmembrane transport

SLC11A2 TRPM2 RYR2

2.73e-05121053GO:0071421
GeneOntologyBiologicalProcessmanganese ion transport

SLC11A2 TRPM2 RYR2

4.48e-05141053GO:0006828
GeneOntologyBiologicalProcesscellular response to purine-containing compound

TRPM2 RYR2 SLC8A1

4.48e-05141053GO:0071415
GeneOntologyBiologicalProcessactin filament-based process

TNIK ROCK2 IQSEC3 ANXA1 TRPM2 SRGAP2 NEB RYR2 TWF1 SPTBN4 SHROOM4 MYH14 NKX2-5 AKAP13 PDCD10

5.81e-0591210515GO:0030029
GeneOntologyCellularComponentpostsynaptic density

TNIK ROCK2 IQSEC3 SRGAP2 GRIN2A CHRM3 SLC8A1 BMPR2 PTPRZ1

4.51e-044511059GO:0014069
GeneOntologyCellularComponentpostsynapse

DOCK1 TNIK ROCK2 IQSEC3 RPS3A SRGAP2 GRIN2A CHRM3 PTN SNX14 SLC8A1 BMPR2 PTPRZ1 PLCB3

5.68e-04101810514GO:0098794
GeneOntologyCellularComponentactin cytoskeleton

KNTC1 ANXA1 NEB TWF1 SPTBN4 SHROOM4 MYH14 SCNN1A AKAP13 CROCC

6.45e-0457610510GO:0015629
GeneOntologyCellularComponentasymmetric synapse

TNIK ROCK2 IQSEC3 SRGAP2 GRIN2A CHRM3 SLC8A1 BMPR2 PTPRZ1

6.74e-044771059GO:0032279
GeneOntologyCellularComponentmast cell granule

ANXA1 CLNK

6.86e-0481052GO:0042629
GeneOntologyCellularComponentearly endosome membrane

SLC11A2 ANXA1 ATP9A TPCN1 STX7 TMEM63A

7.09e-042121056GO:0031901
GeneOntologyCellularComponentsupramolecular fiber

KNTC1 DCDC2C ANXA1 RIBC1 NEB RYR2 TWF1 SPTBN4 SHROOM4 SLC8A1 MYH14 ASPM NINL AKAP13 CFAP53

7.97e-04117910515GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

KNTC1 DCDC2C ANXA1 RIBC1 NEB RYR2 TWF1 SPTBN4 SHROOM4 SLC8A1 MYH14 ASPM NINL AKAP13 CFAP53

8.54e-04118710515GO:0099081
GeneOntologyCellularComponentactin filament

ANXA1 TWF1 SPTBN4 SHROOM4 AKAP13

8.56e-041461055GO:0005884
GeneOntologyCellularComponentpostsynaptic specialization

TNIK ROCK2 IQSEC3 SRGAP2 GRIN2A CHRM3 SLC8A1 BMPR2 PTPRZ1

9.80e-045031059GO:0099572
GeneOntologyCellularComponentcortical actin cytoskeleton

SPTBN4 SHROOM4 SCNN1A AKAP13

1.25e-03931054GO:0030864
GeneOntologyCellularComponentneuron to neuron synapse

TNIK ROCK2 IQSEC3 SRGAP2 GRIN2A CHRM3 SLC8A1 BMPR2 PTPRZ1

1.29e-035231059GO:0098984
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DOCK1 MIA3 POLR1A NEIL1 TRPM2 RNF213 SRGAP2 TBL1XR1 CHRM3 SPTBN4 NCOR2 ATF6 BMPR2 MYH14 SCNN1A AKAP13 ZFHX3 TNFAIP8 GNAZ CROCC TMEM63A

3.90e-0914891062128611215
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

CC2D1B RYR2 FSIP2 NCOR2 EXOC5 DPEP3 AKAP13 CLNK

5.06e-08168106830631154
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ROCK2 MIA3 RNF213 GOLM1 SEC22B CACHD1 HMOX2 ATP9A DMXL1 TPCN1 ATF6 SNX14 BMPR2 TRIM28 MANEAL SCARB2 EMC2

1.36e-0712011061735696571
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ROCK2 IQSEC3 ANXA1 RPS3A SRGAP2 GRIN2A ATP9A PTGS2 TWF1 SPTBN4 MYH14 TRIM28 PTPRZ1 CDC5L GNAZ CROCC

6.97e-0614311061637142655
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

DOCK1 POLR1A CHD8 CACHD1 SIK2 AKAP13 SUZ12

7.47e-06232106725515538
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TNIK ROCK2 IQSEC3 MIA3 CHD8 SRGAP2 GRIN2A TBL1XR1 TWF1 SPTBN4 NCOR2 TRIM28 CDC5L

7.68e-069631061328671696
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

ROCK2 KNTC1 ABCF3 RPS3A OGFR THUMPD1 CC2D1B TBL1XR1 TWF1 MYH14 TRIM28 COPS7B PLCB3 TNFAIP8 CROCC PDCD10

8.57e-0614551061622863883
Pubmed

Immunohistochemical and functional studies for M₃ muscarinic receptors and cyclo-oxygenase-2 expressed in the mouse atrium.

CHRM3 PTGS2

9.20e-062106222726658
Pubmed

Annexin A1 modulates macula densa function by inhibiting cyclooxygenase 2.

ANXA1 PTGS2

9.20e-062106222791338
Pubmed

SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.

SRGAP2 SRGAP2C

9.20e-062106227373832
Pubmed

Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.

TRIM28 SIK2

9.20e-062106234558647
Pubmed

The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway.

PTGS2 ATF6

9.20e-062106228803844
Pubmed

Role of annexin 1 gene expression in mouse craniofacial bone development.

ANXA1 PTGS2

9.20e-062106217405164
Pubmed

Nitric oxide stimulates migration of human endothelial and prostate cancer cells through up-regulation of pleiotrophin expression and its receptor protein tyrosine phosphatase beta/zeta.

PTN PTPRZ1

9.20e-062106219058221
Pubmed

Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.

PTN PTPRZ1

9.20e-062106215908427
Pubmed

Na/Ca exchanger overexpression induces endoplasmic reticulum stress, caspase-12 release, and apoptosis.

CASP12 SLC8A1

9.20e-062106215033764
Pubmed

Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization.

PTN PTPRZ1

9.20e-062106216814777
Pubmed

Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells.

PTN PTPRZ1

9.20e-062106217823238
Pubmed

A basic peptide derived from the HARP C-terminus inhibits anchorage-independent growth of DU145 prostate cancer cells.

PTN PTPRZ1

9.20e-062106217727841
Pubmed

Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.

A1CF RYR2

9.20e-062106222869620
Pubmed

NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.

GRIN2A PTGS2

9.20e-062106235354047
Pubmed

Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.

PTN PTPRZ1

9.20e-062106223084748
Pubmed

Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs.

TRIM28 SUZ12

9.20e-062106217542650
Pubmed

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth.

PTN PTPRZ1

9.20e-062106228569747
Pubmed

Immunohistochemical Markers Distinguishing Cholangiocellular Carcinoma (CCC) from Pancreatic Ductal Adenocarcinoma (PDAC) Discovered by Proteomic Analysis of Microdissected Cells.

ANXA1 ANXA10

9.20e-062106226644413
Pubmed

A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ.

PTN PTPRZ1

9.20e-062106220738847
Pubmed

Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias.

ANXA1 PTGS2

9.20e-062106229254791
Pubmed

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.

RYR2 SLC8A1

9.20e-062106222456474
Pubmed

Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.

A1CF SLC8A1

9.20e-062106223192947
Pubmed

M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency.

CHRM3 PLCB3

9.20e-062106224596086
Pubmed

Characterization of heparin affin regulatory peptide signaling in human endothelial cells.

PTN PTPRZ1

9.20e-062106215797857
Pubmed

Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo.

A1CF RYR2

9.20e-062106223678000
Pubmed

Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.

A1CF RYR2

9.20e-062106224743769
Pubmed

TBLR1 regulates the expression of nuclear hormone receptor co-repressors.

TBL1XR1 NCOR2

9.20e-062106216893456
Pubmed

Pleiotrophin mediates hematopoietic regeneration via activation of RAS.

PTN PTPRZ1

9.20e-062106225250571
Pubmed

Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.

A1CF RYR2

9.20e-062106227621312
Pubmed

ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.

CASP12 ATF6

9.20e-062106226261584
Pubmed

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

RYR2 SLC8A1 NKX2-5

1.81e-0517106327725084
Pubmed

Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.

RYR2 SLC8A1 NKX2-5

2.57e-0519106318316483
Pubmed

Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

SRGAP2 SRGAP2C

2.76e-053106222559944
Pubmed

Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.

A1CF NKX2-5

2.76e-053106220071776
Pubmed

Functional relevance of the stretch-dependent slow force response in failing human myocardium.

RYR2 SLC8A1

2.76e-053106215105296
Pubmed

Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTPβ/ζ signaling pathway.

PTN PTPRZ1

2.76e-053106223777859
Pubmed

Upregulation of fibronectin expression by COX-2 is mediated by interaction with ELMO1.

DOCK1 PTGS2

2.76e-053106220732417
Pubmed

Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart.

A1CF NKX2-5

2.76e-053106225199831
Pubmed

The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases.

CAMTA2 NKX2-5

2.76e-053106216678093
Pubmed

Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.

PTN PTPRZ1

2.76e-053106230497491
Pubmed

Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function.

A1CF PTGS2

2.76e-053106219376970
Pubmed

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging.

ROCK2 A1CF

2.76e-053106230848941
Pubmed

The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure.

A1CF NKX2-5

2.76e-053106224812305
Pubmed

Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin.

PTN SUZ12

2.76e-053106219749796
Pubmed

Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.

PTN PTPRZ1

2.76e-053106217681947
Pubmed

LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.

SLC8A1 SIK2

2.76e-053106237966164
Pubmed

The prognostic significance of annexin A family in glioblastoma.

ANXA1 ANXA10

2.76e-053106234398393
Pubmed

MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.

A1CF PTGS2

2.76e-053106220339119
Pubmed

The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.

RYR2 BMPR2 NKX2-5

4.66e-0523106326321200
Pubmed

Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.

SRGAP2 SRGAP2C

5.50e-054106222559943
Pubmed

Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.

PTN PTPRZ1

5.50e-054106210706604
Pubmed

Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.

PTN PTPRZ1

5.50e-054106227445335
Pubmed

Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.

PTN PTPRZ1

5.50e-054106217368428
Pubmed

Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.

A1CF NKX2-5

5.50e-054106226334248
Pubmed

An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart.

A1CF SLC8A1

5.50e-054106223436819
Pubmed

Mitochondrial fusion is essential for organelle function and cardiac homeostasis.

A1CF NKX2-5

5.50e-054106222052916
Pubmed

The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice.

PTN PTPRZ1

5.50e-054106230667096
Pubmed

A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.

DOCK1 SRGAP2

5.50e-054106223031429
Pubmed

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

TPCN1 STX7

5.50e-054106228855648
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

ABCF3 ANXA1 CHD8 SEC22B NCOR2 MYH14 TRIM28 CDC5L

6.71e-05444106834795231
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

NEB RYR2 PLCB3

7.63e-0527106318468998
Pubmed

Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling.

ANXA1 SEC22B SCARB2 STX7

7.96e-0574106417255364
Pubmed

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.

ROCK2 ABCF3 ANXA1 TWF1 EXOC5 CROCC STX7

8.39e-05339106737232246
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

TNIK KNTC1 MIA3 POLR1A RNF213 SRGAP2 HMOX2 AKAP13 CDC5L CROCC

8.41e-057331061034672954
Pubmed

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

RYR2 ATF6 SLC8A1

8.53e-0528106325332179
Pubmed

Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.

A1CF RYR2

9.15e-055106225193470
Pubmed

High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule.

PTN PTPRZ1

9.15e-05510629507007
Pubmed

Order of six loci at 2q24-q31 and orientation of the HOXD locus.

NEB DLX1

9.15e-05510627896287
Pubmed

Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development.

CHD8 AKAP13

9.15e-055106223071553
Pubmed

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.

PTN PTPRZ1

9.15e-055106229651006
Pubmed

Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.

NCOR2 NKX2-5

9.15e-055106229033129
Pubmed

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout.

A1CF SLC8A1

9.15e-055106222355118
Pubmed

Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.

ANXA1 CHD8 TRIM28 SUZ12 UBE2Q2

9.35e-05148106522898364
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

TNIK CCDC137 DCDC2C CC2D1B SEC22B GRIN2A TWF1 CASP12 MYH14 MANEAL ASPM NINL CFAP53

1.06e-0412421061330973865
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

ANXA1 CHD8 TBL1XR1 DMXL1 NCOR2 PLCB3 CDC5L PDCD10

1.07e-04475106831040226
Pubmed

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.

RPS3A RNF213 TBL1XR1 NCOR2 CDC5L

1.20e-04156106532850835
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

CHRM3 RYR2

1.37e-046106219549818
Pubmed

Subunit structure of the mammalian exocyst complex.

EXOC8 EXOC5

1.37e-04610629405631
Pubmed

Arl13b and the exocyst interact synergistically in ciliogenesis.

EXOC8 EXOC5

1.37e-046106226582389
Pubmed

Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition.

PTN PTPRZ1

1.37e-046106217098867
Pubmed

Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.

PTN PTPRZ1

1.37e-046106219141530
Pubmed

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

A1CF RYR2

1.37e-046106223540699
Pubmed

Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.

PTN PTPRZ1

1.37e-046106225644401
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ROCK2 KNTC1 RNF213 CC2D1B SHROOM4 CDC5L EMC2 TMEM63A

1.38e-04493106815368895
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

MIA3 POLR1A GOLM1 SEC22B CACHD1 HMOX2 ATP9A EXOC8 ATF6 EMC2 STX7

1.45e-049421061131073040
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

SEC22B HMOX2 ATP9A DMXL1 ATF6 SNX14 EMC2 STX7

1.60e-04504106834432599
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TNIK MIA3 RPS3A SEC22B HMOX2 DMXL1 ATF6 EXOC5 ASPM SIK2 AKAP13 CDC5L EMC2 STX7

1.72e-0414871061433957083
Pubmed

Hippo signaling impedes adult heart regeneration.

A1CF NKX2-5

1.91e-047106224255096
Pubmed

The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.

TBL1XR1 NCOR2

1.91e-047106215695367
Pubmed

Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes.

SLC8A1 NKX2-5

1.91e-047106212781968
Pubmed

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

POLR1A SEC22B TPCN1 TRIM28 SCARB2 EMC2 STX7

2.05e-04392106733144569
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

DOCK1 OGFR SRGAP2 EXOC8 DMKN

2.52e-04183106531932471
Pubmed

beta-Catenin is a Nek2 substrate involved in centrosome separation.

ASPM CROCC

2.55e-048106218086858
GeneFamilyExocyst complex

EXOC8 EXOC5

5.23e-0497021055
GeneFamilyAnnexins|Endogenous ligands

ANXA1 ANXA10

1.12e-0313702404
CoexpressionHARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_DN

RPS3A CACHD1 ATP9A VSIR TPCN1 MMRN1 IER5L DPEP3 SCNN1A CCDC68 ZFHX3 ANKRD18A ALPK2

8.36e-0674010513M41202
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5

TNIK IQSEC3 ANXA1 TTC39C RNF213 CACHD1 SPTBN4 SLC8A1 BMPR2 MYH14 AKAP13 TNFAIP8 PCYT1B TMEM63A

1.09e-0572610314Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_1000

NBEAL1 RNF213 SYCP3 CHD8 RYR2 DMXL1 EXOC5 NINL

1.81e-052331038gudmap_developingGonad_e12.5_ovary_k5_1000
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

NEB FSIP2 DMKN SCNN1A SIK2 CLNK

1.58e-0615110562470162f4b56bc505db166a6eb0fa54847759df8
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 GOLM1 CAPN13 IER5L SCNN1A ANKRD18A

4.96e-06184105601c19a830348ab0b9c02c1546a439de70ee10f97
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

OGFR MUC16 PTGS2 RYR2 SLC8A1 ZFHX3

5.28e-06186105623b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellCOVID-19_Mild-Neu_4|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

KNTC1 SNX14 RNASE2 ASPM DLX1 PLCB3

5.44e-061871056714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCellASK452-Immune-Mast_cell|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

TNIK SLC11A2 ANXA1 PTGS2 AKAP13 TNFAIP8

5.61e-061881056840215e16cff90f821f776186284eafcf2350690
ToppCellCOVID-19-Epithelial-Ionocytes|COVID-19 / Condition, Lineage and Cell class

MUC16 GOLM1 PTN SCNN1A CCDC68 CLNK

5.61e-061881056a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCellmild-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KNTC1 NEIL1 TRPM2 SHROOM4 ASPM

6.06e-0610910552f03d6ee8b13424cc6a5bc60ac3461b44dff9d79
ToppCellASK452-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

TNIK SLC11A2 ANXA1 PTGS2 AKAP13 TNFAIP8

6.33e-0619210568269b88ff6073a908f547fcc7c5941f2e8289694
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KNTC1 PTN PTPRZ1 MANEAL ASPM ABHD1

6.92e-0619510565812b1615676f3b77eb4769216b98b360c417c0d
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANXA1 MUC16 GOLM1 TWF1 CAPN13 MYH14

7.33e-0619710565c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellMild_COVID-19-Epithelial-Basal/Club|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

MUC16 CAPN13 PTN MYH14 PTPRZ1 SCNN1A

7.33e-0619710564cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROCK2 GRIN2A CHRM3 RYR2 SPTBN4 SLC8A1

7.55e-0619810568ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellNS-critical-LOC-Epithelial-Secretory_LYPD2|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANXA1 MUC16 GOLM1 CAPN13 MYH14 SCNN1A

7.55e-0619810564a481e1edb80b950c823ed926842cd5132cfb27f
ToppCellcritical-Epithelial|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ANXA1 MUC16 GOLM1 MYH14 DMKN SCNN1A

7.77e-061991056bbb44e2a52f102a6d891ead6c06d6c07221abd33
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 CAPN13 PTN MYH14 PTPRZ1 SCNN1A

7.77e-061991056ec1e110671e7725f752163c7241dbbf638dec2b2
ToppCellNS-critical-d_07-13-Epithelial|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANXA1 MUC16 GOLM1 MYH14 DMKN SCNN1A

7.77e-061991056b88a81cd2a89f4d27100c96ae4324dcee68daf83
ToppCellNS-critical-d_16-33-Epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANXA1 MUC16 GOLM1 MYH14 DMKN SCNN1A

7.77e-0619910563b68197ec01c5f2b315d9e9b6eb02d5f6b5b77a3
ToppCellcontrol-Epithelial|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ANXA1 MUC16 GOLM1 MYH14 DMKN SCNN1A

7.99e-062001056f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCellNS-control-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANXA1 MUC16 GOLM1 MYH14 DMKN SCNN1A

7.99e-062001056d014959891893b6d3854a471fba1dc50c6625a0a
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MIA3 MUC16 GOLM1 CHRM3 SCNN1A TMEM63A

7.99e-062001056c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCell5'-Airway_Nasal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANXA1 MUC16 GOLM1 CAPN13 PTN MYH14

7.99e-062001056f6e967738b4f7b173d6e9977e305f77380dd6c8a
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 GOLM1 CAPN13 PTN MYH14 SCNN1A

7.99e-062001056133853d0f55c63ebe94dd54151f9f1f90650a0d8
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MIA3 MUC16 GOLM1 CHRM3 SCNN1A TMEM63A

7.99e-0620010560eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell5'-Airway_Nasal-Epithelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANXA1 MUC16 GOLM1 CAPN13 PTN MYH14

7.99e-062001056358d71329921451c7f5a56f1db0f9989af2299dc
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTGS2 DMXL1 RNASE2 IER5L DPEP3

2.26e-0514310557adc34d8ad11e57950a5a258ae9bf8f52259385a
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANXA1 TRPM2 VSIR SPTBN4 AKAP13

2.34e-0514410551efa434e577d1f87e02df01667782f414d63bd60
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANXA1 TRPM2 VSIR SPTBN4 AKAP13

2.34e-051441055c0c5f254a960ba5e5f1354599d54e77360e6c2ac
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage-B|PND01-03-samps / Age Group, Lineage, Cell class and subclass

KNTC1 TTC16 RNASE2 ASPM CFAP53

3.03e-0515210555ce8920aedd39a4daf7082153b5e213707c14227
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|World / disease group, cell group and cell class (v2)

NEB DMKN SCNN1A SIK2 CLNK

3.13e-051531055aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCellIPF-Epithelial-Ionocyte|IPF / Disease state, Lineage and Cell class

MUC16 GOLM1 PTN SCNN1A CLNK

3.87e-051601055d65d19f4fae60836bfd4303a1bb7de34e9d83e35
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KBTBD6 TMEM74 IER5L CCDC68 NINL

3.87e-0516010555cd4fbbd2ce671a8377416eff94041a111375dee
ToppCellIPF-Epithelial-Ionocyte|World / Disease state, Lineage and Cell class

MUC16 GOLM1 PTN SCNN1A CLNK

3.99e-051611055f1cd5c938cdc08ad8995371b72493850a6cf277a
ToppCellControl-Epithelial-Ionocyte|World / Disease state, Lineage and Cell class

KBTBD6 TMEM74 MUC16 PTN CLNK

4.11e-051621055e3b9b46ce2faff7d099502df14bbf51e9f183f8c
ToppCellControl-Epithelial-Ionocyte|Control / Disease state, Lineage and Cell class

KBTBD6 TMEM74 MUC16 PTN CLNK

4.23e-051631055bf09fa39bf3e6b3a776d5e79c30c96df572956a3
ToppCellmild-immature_Neutrophil|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KNTC1 TRPM2 SHROOM4 ASPM

4.47e-05831054f7225bc24ad6df3a41375cc4614af824e0db3559
ToppCellsevere-HSPC|severe / disease stage, cell group and cell class

CACHD1 CHRM3 DPEP3 CFAP53 PCYT1B

4.48e-051651055acd837d88ad3786c263f74651a6c0e02fa2fa2c5
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

POLR1A NEIL1 TMEM74 DMKN ZFHX3

4.75e-05167105599db8871c62336bd215efb65e969783d2b6003b0
ToppCellASK428-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

TNIK SYCP3 PTGS2 TPCN1 ABHD16A

4.88e-051681055c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCellControl-NK|Control / Disease group and Cell class

SYCP3 CACHD1 MMRN1 ZFHX3 CLNK

4.88e-051681055683d389c8a1e791bfc773e63148115a21a6566db
ToppCellBronchial_Biopsy-Immune-T_and_NK|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

TNIK MMRN1 FSIP2 ASPM CCDC68

4.88e-051681055435b2f238fbb3f50427e8cdecf2220615015153c
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell-NK-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYCP3 CACHD1 MMRN1 SPTBN4 CLNK

5.02e-051691055e9c0e0f4c421c7bdbf1a7e33002f3cf22ea307cb
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYCP3 CACHD1 MMRN1 SPTBN4 CLNK

5.02e-051691055d375a1df1ecc938f66bad92e54b8cda26ca9c472
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell-NK|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYCP3 CACHD1 MMRN1 SPTBN4 CLNK

5.02e-05169105558f805c0be507bd5fadc9ea3555032daabbc8ab8
ToppCelldroplet-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK1 ANXA1 PTGS2 DMKN SCNN1A

5.17e-051701055dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MUC16 CHRM3 CAPN13 PTPRZ1 SCNN1A

6.26e-051771055a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MUC16 CHRM3 CAPN13 PTPRZ1 SCNN1A

6.26e-051771055363e07b0f347f3716d530a28ead854b98e27d37c
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KNTC1 RIBC1 ATP9A ASPM GNAZ

6.43e-051781055c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK ANXA1 NEB AKAP13 ZNF639

6.60e-05179105530efe1f0394c0edb27b91890b5c4637b73cbc5ec
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THUMPD1 ATP9A PTN CASP12 NINL

6.60e-051791055ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCellLA-06._Ventricular_Cardiomyocyte_II|LA / Chamber and Cluster_Paper

A1CF RYR2 SLC8A1 ANXA10

6.68e-05921054fad2e02ae858e3a9bbe51ad1c689f7e31d11ce0e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PTN SCNN1A CCDC68 TNFAIP8 CLNK

6.77e-051801055cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANXA1 MUC16 VSIR DMKN ASPM

6.95e-0518110553dcb74b28f93be35ddf4de1937f7e30b25e11927
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANXA1 MUC16 VSIR DMKN ASPM

6.95e-0518110557679a5980011d6dfb1aaca7abf678c29b6f819bb
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 TTC16 PTN SHROOM4 PTPRZ1

7.14e-0518210558a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIN2A PTN MYH14 PTPRZ1 PCYT1B

7.14e-051821055a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRC3B ASPM AKAP13 ZFHX3 ANKRD18A

7.14e-05182105572e65a23cd36085bc880087d3cae92395de918a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRC3B ASPM AKAP13 ZFHX3 ANKRD18A

7.14e-05182105505c167158815bf25d509df59ab386e1990712765
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 TTC16 PTN SHROOM4 PTPRZ1

7.14e-051821055e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCellPND10-Immune-Immune_Myeloid-Dendritic-cDC1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLR1A OGFR RIBC1 ASPM CLNK

7.32e-051831055ab38264daddccdf5ffb75ff2210b27423eca6bc0
ToppCellPND10-Immune-Immune_Myeloid-Dendritic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLR1A OGFR RIBC1 ASPM CLNK

7.32e-051831055e4911601dca2c0ecb448cdb6b222dedfc0c8bf6c
ToppCellPND10-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLR1A OGFR RIBC1 ASPM CLNK

7.32e-051831055263bfa1d8a7314bc3156c735c403c3bab8ea4dac
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

ABCF3 CHRM3 PTPRZ1 ZNF639 PCYT1B

7.51e-051841055ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK TTC39C RYR2 AKAP13 TMEM63A

7.51e-051841055d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TNIK PTN SLC8A1 LRRC3B DMKN

7.91e-0518610558915436d09775f2828a7678af203b1082b36e21c
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

TNIK ROCK2 NBEAL1 THUMPD1 BMPR2

7.91e-05186105503db813598b67b1e08f759758a1c2023396921fa
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 GRIN2A RYR2 SPTBN4 DLX1

8.11e-051871055e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 GRIN2A RYR2 SPTBN4 DLX1

8.11e-05187105524cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

GRIN2A PTN SCNN1A CCDC68 CLNK

8.11e-051871055ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC3 GRIN2A RYR2 SPTBN4 DLX1

8.11e-0518710552f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell10x5'v1-week_17-19-Hematopoietic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RYR2 MMRN1 SHROOM4 CCDC68 PCYT1B

8.32e-051881055c00ba0abd0c7bb2c8f9166a2ac6220aae4f4d857
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 PTN SHROOM4 ZFHX3 TMEM63A

8.53e-05189105542ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANXA1 CHRM3 VSIR MMRN1 LRRC3B

8.74e-0519010551307688255a1250fa300edf2c41f1affe31dcc98
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANXA1 TRPM2 SRGAP2 SRGAP2C SLC8A1

8.74e-0519010552d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 PTN SHROOM4 PTPRZ1 TMEM63A

8.74e-0519010552de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 GOLM1 CAPN13 IER5L SCNN1A

8.74e-05190105523f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

MUC16 CAPN13 MYH14 PTPRZ1 SCNN1A

8.74e-05190105551ca9ef4df3220487152fcf684147730637c7cc1
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 GOLM1 CAPN13 IER5L SCNN1A

8.74e-0519010553c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 GOLM1 CAPN13 MYH14 SCNN1A

8.96e-05191105514851529025cfc2b665f71ebad04150ec543da7a
ToppCell10x5'v1-week_14-16-Hematopoietic-MK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TNIK RYR2 MMRN1 GNAZ ABHD16A

8.96e-0519110557edc22e7e70697fb22690699efb352577162709b
ToppCelldroplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 SLC8A1 MYH14 NKX2-5 ALPK2

8.96e-05191105597fb4232417a39801e87725755fd16a57c250209
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 GOLM1 CAPN13 PTN ABHD16A

8.96e-051911055529068029fb461df766135576dd0d8b5980f9bc0
ToppCelldroplet-Heart-nan-3m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 SLC8A1 MYH14 NKX2-5 ALPK2

8.96e-05191105564070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 GOLM1 CAPN13 MYH14 SCNN1A

8.96e-051911055e14b22e882ac92acf8c8b6ee997ef8e799c7a8d5
ToppCell10x5'v1-week_14-16-Hematopoietic-MK-MK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TNIK RYR2 MMRN1 GNAZ ABHD16A

9.18e-051921055b877d14be9d04ab0010e340909e3a23de92613db
ToppCelldroplet-Heart-nan-24m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 SLC8A1 MYH14 NKX2-5 ALPK2

9.18e-051921055f6a4e348406a852ace9fb21db8fbdff539217645
ToppCelldroplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 SLC8A1 MYH14 NKX2-5 ALPK2

9.18e-0519210551a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCellClub_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

MUC16 GOLM1 CAPN13 PTPRZ1 SCNN1A

9.41e-0519310556582c0367052b9d10fb629c383ee0c55872afd2d
ToppCellControl-NK_CD56bright|Control / Disease condition and Cell class

NEIL1 MMRN1 DMKN ZFHX3 CLNK

9.41e-0519310558b1e7a226a6057e1097c1525984127b54e823876
ToppCellClub_cells|World / lung cells shred on cell class, cell subclass, sample id

MUC16 GOLM1 CAPN13 PTPRZ1 SCNN1A

9.41e-0519310559d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCellCOPD-Myeloid-Macrophage|World / Disease state, Lineage and Cell class

SRGAP2 ATF6 SRGAP2C SLC8A1 AKAP13

9.64e-0519410557d682408e9a6239a4e47befc9376e760cc3d133a
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RPS3A SRGAP2 SRGAP2C SLC8A1 CLNK

9.64e-051941055bde6830a281f7cd7fd1733e40a41ddd2673ba88e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 TNIK RNF213 MYH14 TNFAIP8

9.87e-051951055938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCellNasal_Brush|World / Tissue, Lineage and Cell class of Lung Cells from 10X

MUC16 GOLM1 CAPN13 PTN SCNN1A

9.87e-0519510557509b980b6b293df02bec619ef5b83a6c7b49c03
ToppCellIIF-Lymphocyte-T_NK-CD4_TCM|IIF / Disease, Lineage and Cell Type

NBEAL1 ANXA1 RPS3A TTC39C TNFAIP8

9.87e-0519510558f5d469ef00132637154f6e8847ba4d1e4f008cb
ToppCellNS-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MUC16 GOLM1 CAPN13 MYH14 SCNN1A

9.87e-051951055b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNF213 GOLM1 CAPN13 PTN SCNN1A

9.87e-0519510553f8ed20ad17afe1545e574e5ca5fe33c3704c7f3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 TNIK RNF213 MYH14 TNFAIP8

9.87e-051951055d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCelldistal-Hematologic-Basophil/Mast_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TNIK SLC11A2 PTGS2 AKAP13 TNFAIP8

9.87e-0519510554f83449fce3717518e2acbba1a4b3bea765c0bdb
ToppCell3'-Airway_Nasal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 GOLM1 CAPN13 PTN SCNN1A

9.87e-0519510557ffbdbe95b248699bf6300322d084d21a4a4b1b8
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

TNIK TTC39C ANKRD18A TNFAIP8 TMEM63A

9.87e-05195105522191d361af136942508f1553ff41a626ed982ad
Diseaseheart septal defect (is_implicated_in)

BMPR2 NKX2-5

7.21e-0541032DOID:1681 (is_implicated_in)
Diseasebrain ischemia (implicated_via_orthology)

ANXA1 PTGS2 SLC8A1

2.49e-04351033DOID:2316 (implicated_via_orthology)
Diseasebrain ischemia (biomarker_via_orthology)

SLC11A2 PTGS2 CASP12 SLC8A1

4.58e-041021034DOID:2316 (biomarker_via_orthology)
DiseaseProteinuria

MUC16 PTGS2 SCNN1A

4.61e-04431033C0033687
Diseaseglioblastoma (is_marker_for)

PTGS2 PTN ASPM

4.93e-04441033DOID:3068 (is_marker_for)
Diseasedry eye syndrome (is_marker_for)

ANXA1 MUC16

5.33e-04101032DOID:10140 (is_marker_for)
Diseasecerebral cavernous malformation (implicated_via_orthology)

RNF213 PDCD10

6.50e-04111032DOID:0060669 (implicated_via_orthology)
DiseaseCognitive impairment

RYR2 DMXL1

6.50e-04111032HP_0100543
Diseasepulmonary fibrosis (biomarker_via_orthology)

ANXA1 PTGS2 NKX2-5

7.19e-04501033DOID:3770 (biomarker_via_orthology)
Diseaseesophagus adenocarcinoma (is_marker_for)

PTGS2 CDC5L

7.78e-04121032DOID:4914 (is_marker_for)
DiseaseAcute Cerebrovascular Accidents

PTGS2 NKX2-5 ZFHX3

9.00e-04541033C0751956
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

CASP12 PTPRZ1

9.18e-04131032DOID:332 (biomarker_via_orthology)
Diseasepleurisy (implicated_via_orthology)

ANXA1 PTGS2

9.18e-04131032DOID:10247 (implicated_via_orthology)
Diseasetetralogy of Fallot (implicated_via_orthology)

DOCK1 NKX2-5

1.07e-03141032DOID:6419 (implicated_via_orthology)
Diseaserenal cell carcinoma (biomarker_via_orthology)

ANXA1 PTGS2

1.07e-03141032DOID:4450 (biomarker_via_orthology)
DiseaseCerebrovascular accident

PTGS2 NKX2-5 ZFHX3

1.35e-03621033C0038454
Diseasepulmonary fibrosis (is_implicated_in)

CHRM3 PTGS2

1.40e-03161032DOID:3770 (is_implicated_in)
Diseasehigh altitude adaptation

KNTC1 EXOC8

1.59e-03171032EFO_0009105
DiseaseMalignant Glioma

PTGS2 DMXL1 SUZ12

1.91e-03701033C0555198
Diseasemixed gliomas

PTGS2 DMXL1 SUZ12

1.91e-03701033C0259783
Diseasepulmonary non-tuberculous mycobacterial infection

TRPM2 CHRM3

1.99e-03191032MONDO_0018469
Diseasediet measurement, body mass index

DOCK1 TBL1XR1

2.20e-03201032EFO_0004340, EFO_0008111
DiseaseAutistic Disorder

CHD8 GRIN2A TBL1XR1 PTGS2 DLX1

2.26e-032611035C0004352
Diseasenephrotic syndrome (implicated_via_orthology)

PTGS2 SCNN1A

3.17e-03241032DOID:1184 (implicated_via_orthology)
DiseaseAutism Spectrum Disorders

CHD8 RYR2 DLX1

3.32e-03851033C1510586

Protein segments in the cluster

PeptideGeneStartEntry
ERAVQAYRALKQRQQ

CCDC137

256

Q6PK04
KNRNQLREYQLEGVN

CHD8

806

Q9HCK8
NYQALDADFRKLRQQ

CDC5L

231

Q99459
NKSYQQLRLVFQEFQ

ANXA10

201

Q9UJ72
RYSQQLNDLKAENAR

ANKRD18A

386

Q8IVF6
QVLRANQYKENHNRT

COPS7B

191

Q9H9Q2
NAIKQLNNYEIRNGR

A1CF

111

Q9NQ94
NNDELIQRNYKLAAQ

ALPK2

1966

Q86TB3
RNQSSENKRQLANYN

ABHD16A

136

O95870
LNQQREYEAQQQYRQ

ABCF3

421

Q9NUQ8
IDRFRYNANRASQVQ

ABCF3

441

Q9NUQ8
QQYQQRQSVIFHKRA

CHRM3

571

P20309
RQDLANLQKQQAQYL

AKAP13

2581

Q12802
FNRYLDVVNRNKQVV

CACHD1

96

Q5VU97
FQQSRRAAVLIQQHY

CAMTA2

1121

O94983
SQQSIFNRYAQQRLD

CAPN13

501

Q6MZZ7
FNRYAQQRLDIDATQ

CAPN13

506

Q6MZZ7
YLRDQQRNQTNTFFG

ATF6

636

P18850
QALNRRFQQTQYLAL

DLX1

141

P56177
ALRNVAQRLFENYQT

CCDC68

126

Q9H2F9
LNIRNKEFNYLHNRN

CASP12

101

Q6UXS9
YVFDLCQRQQRQLFQ

DMXL1

2911

Q9Y485
QQYQANRAAKLQRQH

ASPM

2366

Q8IZT6
KNRKVYRQQQNSNIF

ASDURF

46

L0R819
YRQQQNSNIFFLADR

ASDURF

51

L0R819
FNRKARQENLRYNNM

NBEAL1

1746

Q6ZS30
MQAQQYQQQRRKFAA

PTN

1

P21246
KRNNAQRQQIKAAYL

ANXA1

71

P04083
YQRNKRNIEDALNQL

MUC16

14346

Q8WXI7
SYRRRGKSQQQQQQQ

NCOR2

486

Q9Y618
YQQFRENVLRNLADK

NEIL1

141

Q96FI4
NDNQRYNFVLQVAKT

MMRN1

791

Q13201
QRVQYDISKSRFQRQ

FSIP2

4766

Q5CZC0
GYLARRAFQKRQQQQ

MYH14

816

Q7Z406
NVSFINEKRYRFQNQ

PCYT1B

231

Q9Y5K3
NNVFKKYQYQNRRAL

PDCD10

146

Q9BUL8
NKRYNVSQQALDLQN

NXF5

111

Q9H1B4
LLFNKQFQYQNRIAA

PTGS2

351

P35354
QFQYQNRIAAEFNTL

PTGS2

356

P35354
QKANDENRRTYQNLV

KNTC1

126

P50748
VNRNNKQEVREANKY

SLC11A2

281

P49281
NAFNNLKARARIANN

LRRC3B

131

Q96PB8
QRYPRNVINNQKYNF

ATP9A

51

O75110
NVDNAQQFKQLYRAR

HMOX2

191

P30519
LQNNFREQQYKFSRQ

PTPRZ1

281

P23471
AADRRNVKQNQAFQY

TMEM63A

591

O94886
AQNLKRNVYQNYRQF

EXOC8

56

Q8IYI6
FRQYQLSKNFEKIRN

IQSEC3

326

Q9UPP2
SQAQVYELERRFKQQ

NKX2-5

146

P52952
DEAKRYQEFQNRQVQ

PLCB3

1026

Q01970
NFARRQRLAQEYRKQ

CFAP53

436

Q96M91
RNANLYFLDVVQQAN

EXOC5

476

O00471
RRKLQAYQEGQQRQA

CROCC

156

Q5TZA2
AVYIQRQFEDLNRNK

GNAZ

301

P19086
VQNKVFLRAINQYAD

DOCK1

991

Q14185
QKRAGRDDQNYNYNQ

DMKN

421

Q6E0U4
VQQRYANVEKNSQRK

DCDC2C

226

A8MYV0
IQTFKENQQCQKRYF

CCDC191

316

Q8NCU4
NRQNFINEKNIYRVP

BMPR2

236

Q13873
EKNRNSINYERQQAQ

BMPR2

581

Q13873
QYQRAALQAKRSQDL

CC2D1B

546

Q5T0F9
NNHNTRNRVNGKYYE

MANEAL

371

Q5VSG8
SRKYFAQALKLNNRN

EMC2

211

Q15006
QRYKNVLQDVNLRNF

DPEP3

106

Q9H4B8
YGRLQQDVLQFQKNQ

GOLM1

131

Q8NBJ4
QQYQSQAKQLFRKLN

SEC22B

31

O75396
LSRQNNYTVNNKRNG

SCNN1A

506

P37088
DFVAKLQDNQRFRYN

RYR2

1931

Q92736
RYAELYRRQQQQQQQ

IER5L

51

Q5T953
RKLRSQAQSYIAQNF

KBTBD6

186

Q86V97
GRAQNYQKRFQNLNW

OGFR

191

Q9NZT2
EEKQNKFQVYQLRFQ

POLR1A

1306

O95602
DQRQKLNQEYSQQFL

SYCP3

116

Q8IZU3
KEQQSLQRFQKYFNV

MIA3

931

Q5JRA6
NQQLSRAADYQRKSR

STX7

221

O15400
RNNQIRKTSYAQHQQ

RPS3A

146

P61247
RLFLQKQSQLQAYFN

SIK2

721

Q9H0K1
KYRLFRAAQQQKQQQ

SHROOM4

1111

Q9ULL8
YRELRNKANIQFGDN

SCARB2

91

Q14108
IAKRRANQQETEQFY

SRGAP2C

436

P0DJJ0
KLAILYRNNQFNQDE

TNFAIP8

81

O95379
EVLNRQNQNYKDQLS

NINL

1136

Q9Y2I6
QQAYRDKLAQQQAAA

TBL1XR1

96

Q9BZK7
VINNYQRRCKNQNTF

RNASE2

56

P10153
QALRDGYQAVVFNNR

ABHD1

146

Q96SE0
VYNVKIRFLERNQQF

CLNK

356

Q7Z7G1
LRRFNQNQDLDTFQY

RNF213

2171

Q63HN8
RVQFGANKNQYNLAR

UBE2Q2

336

Q8WVN8
ANKNQYNLARAQQSY

UBE2Q2

341

Q8WVN8
QGKVYNLINRRRFQQ

TNIK

1076

Q9UKE5
TFQQRRYKCEQVFNE

ZNF549

216

Q6P9A3
FADGIKARNRNQNYL

ZNF639

71

Q9UID6
QQGQFRYNLERQQQE

RIBC1

156

Q8N443
ANRAENTERKQNQNY

SNX14

766

Q9Y5W7
NYLQNRQFQQKQRPE

TRPM2

1131

O94759
QFLYNNNTRQQTEAR

SUZ12

431

Q15022
YKQRQAASNRRAQEL

VSIR

216

Q9H7M9
IAKRRANQQETEQFY

SRGAP2

436

O75044
ALRKNKNIDNFLNRY

ROCK2

61

O75116
NANYNLQRAFRTAEQ

SPTBN4

236

Q9H254
LQNRGREAYFNLQKA

TTC23L

176

Q6PF05
ARERYLTFKALNQNN

TPCN1

376

Q9ULQ1
QNLRRAYSLQQDNCK

TTC16

116

Q8NEE8
FTYVDKNINLEQRNR

TMEM74

111

Q96NL1
QYFQRAVKDELCRQN

TTC39C

506

Q8N584
FQIVYKSRNNSHVNR

THUMPD1

196

Q9NXG2
AFQALEKLNNRQLNY

TWF1

186

Q12792
QYQFLEDAVRNQRKL

TRIM28

241

Q13263
QNARQKARKNYENQG

ZFHX3

2291

Q15911
QQQKSRAFYRIQATR

SLC8A1

356

P32418
FVANRQKDNLNNYVF

GRIN2A

966

Q12879
RVRENQKNFSLLQYQ

NEB

6106

P20929