Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LRR_8	LRFN3 PIDD1 LRRN2 CHADL TPBGL SCRIB TLR9 LRRC58	1.94e-07	171	68	8	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRFN3 PIDD1 LRRN2 CHADL TPBGL SCRIB TLR9 LRRC58	2.53e-07	177	68	8	IPR003591
Domain	LRR_TYP	LRFN3 PIDD1 LRRN2 CHADL TPBGL SCRIB TLR9 LRRC58	2.53e-07	177	68	8	SM00369
Domain	Leu-rich_rpt	LRFN3 TONSL PIDD1 LRRN2 CHADL TPBGL SCRIB TLR9 LRRC58	5.82e-07	271	68	9	IPR001611
Domain	-	LRFN3 TONSL PIDD1 LRRN2 CHADL TPBGL SCRIB TLR9 LRRC58	2.37e-06	321	68	9	3.80.10.10
Domain	L_dom-like	LRFN3 TONSL PIDD1 LRRN2 CHADL TPBGL SCRIB TLR9 LRRC58	2.82e-06	328	68	9	IPR032675
Domain	LRR_1	LRFN3 PIDD1 LRRN2 CHADL SCRIB TLR9 LRRC58	1.46e-05	219	68	7	PF00560
Domain	LRR	PIDD1 LRRN2 CHADL SCRIB TLR9 LRRC58	9.06e-05	201	68	6	PS51450
Domain	Cys-rich_flank_reg_C	LRFN3 LRRN2 CHADL TPBGL	3.24e-04	90	68	4	IPR000483
Domain	LRRCT	LRFN3 LRRN2 CHADL TPBGL	3.24e-04	90	68	4	SM00082
Domain	MIP_CS	AQP8 AQP2	5.77e-04	10	68	2	IPR022357
Domain	MIP	AQP8 AQP2	1.16e-03	14	68	2	PS00221
Domain	MIP	AQP8 AQP2	1.16e-03	14	68	2	PF00230
Domain	MIP	AQP8 AQP2	1.33e-03	15	68	2	IPR000425
Domain	-	AQP8 AQP2	1.33e-03	15	68	2	1.20.1080.10
Domain	Aquaporin-like	AQP8 AQP2	1.33e-03	15	68	2	IPR023271
Domain	Ank	NFKB1 SOWAHD TONSL POTEJ ACAP3	1.45e-03	228	68	5	PF00023
Domain	OAR	PAX7 VSX2	1.52e-03	16	68	2	PS50803
Domain	OAR_dom	PAX7 VSX2	1.52e-03	16	68	2	IPR003654
Domain	-	NFKB1 SOWAHD TONSL POTEJ ACAP3	2.09e-03	248	68	5	1.25.40.20
Domain	ANK	NFKB1 SOWAHD TONSL POTEJ ACAP3	2.20e-03	251	68	5	SM00248
Domain	ANK_REPEAT	NFKB1 SOWAHD TONSL POTEJ ACAP3	2.28e-03	253	68	5	PS50088
Domain	Ankyrin_rpt-contain_dom	NFKB1 SOWAHD TONSL POTEJ ACAP3	2.32e-03	254	68	5	IPR020683
Domain	ANK_REP_REGION	NFKB1 SOWAHD TONSL POTEJ ACAP3	2.32e-03	254	68	5	PS50297
Domain	Ankyrin_rpt	NFKB1 SOWAHD TONSL POTEJ ACAP3	2.65e-03	262	68	5	IPR002110
Domain	DEATH	NFKB1 PIDD1	4.32e-03	27	68	2	SM00005
Domain	Aden_trnslctor	SLC25A32 SLC25A29	4.64e-03	28	68	2	IPR002113
Domain	LRRNT	LRFN3 LRRN2 CHADL	5.49e-03	98	68	3	IPR000372
Domain	LRRNT	LRFN3 LRRN2 CHADL	5.49e-03	98	68	3	SM00013
Domain	Mit_carrier	SLC25A32 SLC25A29	6.04e-03	32	68	2	IPR002067
Domain	Death	NFKB1 PIDD1	6.41e-03	33	68	2	PF00531
Domain	Ank_2	NFKB1 SOWAHD TONSL POTEJ	7.83e-03	215	68	4	PF12796
Domain	Death_domain	NFKB1 PIDD1	8.44e-03	38	68	2	IPR000488
Domain	DEATH_DOMAIN	NFKB1 PIDD1	8.44e-03	38	68	2	PS50017
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TINAGL1 SOX4 EPPK1 WIZ FNTB CSAD ZNF335 FBRS TMEM187 IRS1 ZFPM1 TEP1 PRRT4	2.33e-07	1105	69	13	35748872
Pubmed	Dual-mode operation of neuronal networks involved in left-right alternation.	LBX1 PAX7 VSX2	4.16e-07	8	69	3	23812590
Pubmed	TLR9 and NF-κB are partially involved in activation of human neutrophils by Helicobacter pylori and its purified DNA.	NFKB1 TLR9	3.88e-06	2	69	2	24987851
Pubmed	Muscle stem cell fate is controlled by the cell-polarity protein Scrib.	PAX7 SCRIB	3.88e-06	2	69	2	25704816
Pubmed	Post-traumatic anxiety associates with failure of the innate immune receptor TLR9 to evade the pro-inflammatory NFκB pathway.	NFKB1 TLR9	3.88e-06	2	69	2	22832815
Pubmed	Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF-κB signals.	GPER1 NFKB1	3.88e-06	2	69	2	26842883
Pubmed	Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord.	LBX1 PAX7 VSX2	4.98e-06	17	69	3	17219401
Pubmed	Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms.	LBX1 PAX7 VSX2	9.69e-06	21	69	3	17321515
Pubmed	Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.	LBX1 PAX7 VSX2	1.12e-05	22	69	3	21775418
Pubmed	Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.	LBX1 PAX7 VSX2	1.12e-05	22	69	3	12435629
Pubmed	Differential expression and inhibitory effects of aquaporins on the development of adenomyosis.	AQP8 AQP2	1.16e-05	3	69	2	32901888
Pubmed	Activation of NF-κB via endosomal Toll-like receptor 7 (TLR7) or TLR9 suppresses murine herpesvirus 68 reactivation.	NFKB1 TLR9	1.16e-05	3	69	2	24942583
Pubmed	Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells.	NFKB1 TLR9	1.16e-05	3	69	2	19618291
Pubmed	Structural Basis for Mutations of Human Aquaporins Associated to Genetic Diseases.	AQP8 AQP2	1.16e-05	3	69	2	29799470
Pubmed	Toll-like receptor 9 agonist inhibits ERalpha-mediated transactivation by activating NF-kappaB in breast cancer cell lines.	NFKB1 TLR9	1.16e-05	3	69	2	19724876
Pubmed	Toll-like receptors expression and NF-κB activation in peritoneal leukocytes in morphine-mediated impairment of zymosan-induced peritonitis in swiss mice.	NFKB1 TLR9	1.16e-05	3	69	2	22915067
Pubmed	Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-κB activity.	NFKB1 ALOX12	1.16e-05	3	69	2	32037090
Pubmed	mRNA expression of TLR4, TLR9 and NF-κB in a neonatal murine model of necrotizing enterocolitis.	NFKB1 TLR9	1.16e-05	3	69	2	27357505
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX4 LBX1 ZNF335 NFKB1 TRPS1 BOLA1 ZFPM1 PAX7 TSC22D2 VSX2	1.18e-05	908	69	10	19274049
Pubmed	Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei.	ZFPM1 PAX7 VSX2	1.67e-05	25	69	3	26718003
Pubmed	The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells.	NFKB1 TLR9	2.32e-05	4	69	2	20130217
Pubmed	Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.	NFKB1 PIDD1	2.32e-05	4	69	2	17159900
Pubmed	The role of SF/HGF and c-Met in the development of skeletal muscle.	LBX1 PAX7	3.86e-05	5	69	2	10079225
Pubmed	TLR9 Regulates the NF-κB-NLRP3-IL-1β Pathway Negatively in Salmonella-Induced NKG2D-Mediated Intestinal Inflammation.	NFKB1 TLR9	3.86e-05	5	69	2	28576980
Pubmed	A mechanism for the suppression of interleukin-1-induced nuclear factor kappaB activation by protein phosphatase 2Ceta-2.	NFKB1 PPM1M	3.86e-05	5	69	2	19594441
Pubmed	TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus.	NFKB1 TLR9	5.79e-05	6	69	2	26578650
Pubmed	Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression.	NFKB1 TLR9	5.79e-05	6	69	2	17464186
Pubmed	Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes.	NFKB1 TLR9	5.79e-05	6	69	2	37733587
Pubmed	PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development.	PAX7 VSX2	5.79e-05	6	69	2	9409667
Pubmed	Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord.	LBX1 VSX2	5.79e-05	6	69	2	11239430
Pubmed	Role of aquaporin water channels in kidney and lung.	AQP8 AQP2	8.09e-05	7	69	2	9822113
Pubmed	TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.	NFKB1 TLR9	8.09e-05	7	69	2	24114535
Pubmed	Wt1 Positive dB4 Neurons in the Hindbrain Are Crucial for Respiration.	LBX1 VSX2	8.09e-05	7	69	2	33328840
Pubmed	RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.	LBX1 PAX7	1.08e-04	8	69	2	17360543
Pubmed	Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation.	FEZF2 LRP8	1.08e-04	8	69	2	26341353
Pubmed	Inhibitory SMAD6 interferes with BMP-dependent generation of muscle progenitor cells and perturbs proximodistal pattern of murine limb muscles.	LBX1 PAX7	1.38e-04	9	69	2	37272529
Pubmed	Aquaporin molecular biology and clinical abnormalities of the water transport channels.	AQP8 AQP2	1.38e-04	9	69	2	9757370
Pubmed	Expression of mRNAs of the aquaporin family in mouse oocytes and embryos.	AQP8 AQP2	1.73e-04	10	69	2	10788316
Pubmed	Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia.	AQP8 AQP2	1.73e-04	10	69	2	10318966
Pubmed	Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea.	AQP8 AQP2	1.73e-04	10	69	2	12031518
Pubmed	Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons.	LBX1 VSX2	1.73e-04	10	69	2	24267650
Pubmed	mRNAs encoding aquaporins are present during murine preimplantation development.	AQP8 AQP2	1.73e-04	10	69	2	11066060
Pubmed	A Functional Topographic Map for Spinal Sensorimotor Reflexes.	LBX1 VSX2	1.73e-04	10	69	2	33181065
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	EPPK1 TONSL IPO4 LRRC58 VPS51	1.83e-04	264	69	5	32814769
Pubmed	Water permeability and characterization of aquaporin-11.	AQP8 AQP2	2.11e-04	11	69	2	21251984
Pubmed	Novel variants in human Aquaporin-4 reduce cellular water permeability.	AQP8 AQP2	2.11e-04	11	69	2	18511455
Pubmed	Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.	AQP8 AQP2	2.11e-04	11	69	2	1510932
Pubmed	Mercury-sensitive residues and pore site in AQP3 water channel.	AQP8 AQP2	2.11e-04	11	69	2	9369468
Pubmed	Functional characterization and localization of AQP3 in the human colon.	AQP8 AQP2	2.11e-04	11	69	2	10510269
Pubmed	Aquaporin-1, nothing but a water channel.	AQP8 AQP2	2.11e-04	11	69	2	14701836
Pubmed	Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract.	AQP8 AQP2	2.11e-04	11	69	2	18501347
Pubmed	Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum.	AQP8 AQP2	2.11e-04	11	69	2	11573934
Pubmed	Purification and functional characterization of aquaporin-8.	AQP8 AQP2	2.11e-04	11	69	2	15948717
Pubmed	Identification of arylsulfonamides as Aquaporin 4 inhibitors.	AQP8 AQP2	2.11e-04	11	69	2	17178220
Pubmed	Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues.	AQP8 AQP2	2.11e-04	11	69	2	7530250
Pubmed	Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.	AQP8 AQP2	2.11e-04	11	69	2	16596446
Pubmed	Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.	AQP8 AQP2	2.11e-04	11	69	2	1373524
Pubmed	Mechanism of selectivity in aquaporins and aquaglyceroporins.	AQP8 AQP2	2.11e-04	11	69	2	18202181
Pubmed	Functional characterization of human aquaporin 9 as a facilitative glycerol carrier.	AQP8 AQP2	2.11e-04	11	69	2	18762715
Pubmed	Functional and molecular characterization of the human neutral solute channel aquaporin-9.	AQP8 AQP2	2.11e-04	11	69	2	10564231
Pubmed	Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.	AQP8 AQP2	2.11e-04	11	69	2	9806845
Pubmed	Structural determinants of water permeation through aquaporin-1.	AQP8 AQP2	2.11e-04	11	69	2	11034202
Pubmed	Functional impairment of lens aquaporin in two families with dominantly inherited cataracts.	AQP8 AQP2	2.11e-04	11	69	2	11001937
Pubmed	Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5.	AQP8 AQP2	2.11e-04	11	69	2	9829975
Pubmed	The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers.	AQP8 AQP2	2.11e-04	11	69	2	11076974
Pubmed	Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin.	AQP8 AQP2	2.11e-04	11	69	2	12084581
Pubmed	Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability.	AQP8 AQP2	2.11e-04	11	69	2	9405233
Pubmed	The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.	LBX1 PAX7	2.53e-04	12	69	2	12062039
Pubmed	Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.	SOX4 VSX2	2.53e-04	12	69	2	23649630
Pubmed	Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons.	LBX1 PAX7	2.53e-04	12	69	2	28625870
Pubmed	Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1.	LBX1 PAX7	2.98e-04	13	69	2	15576403
Pubmed	Cis-regulatory control of corticospinal system development and evolution.	SOX4 FEZF2	2.98e-04	13	69	2	22678282
Pubmed	Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo.	LBX1 PAX7	2.98e-04	13	69	2	21143873
Pubmed	Molecular markers of cardiac endocardial cushion development.	SOX4 ZFPM1	2.98e-04	13	69	2	14648841
Pubmed	V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.	LBX1 VSX2	2.98e-04	13	69	2	24698273
Pubmed	Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.	LBX1 PAX7	2.98e-04	13	69	2	22159578
Pubmed	Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.	SOX4 VSX2	2.98e-04	13	69	2	28411269
Pubmed	Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer.	SOX4 LBX1	2.98e-04	13	69	2	20692247
Pubmed	Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.	NFKB1 TLR9	3.48e-04	14	69	2	26682986
Pubmed	Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1.	LBX1 PAX7	3.48e-04	14	69	2	15528197
Pubmed	FOXG1 sequentially orchestrates subtype specification of postmitotic cortical projection neurons.	SOX4 FEZF2	3.48e-04	14	69	2	35613274
Pubmed	Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors.	LBX1 PAX7	4.01e-04	15	69	2	20059958
Pubmed	Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.	AQP8 AQP2	4.01e-04	15	69	2	34540996
Pubmed	Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons.	LBX1 PAX7	4.01e-04	15	69	2	16715081
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	LBX1 PAX7	4.01e-04	15	69	2	17194759
Pubmed	Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle.	LBX1 PAX7	4.01e-04	15	69	2	25220152
Pubmed	Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.	LBX1 PAX7	4.01e-04	15	69	2	15604102
Pubmed	Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply.	TONSL IPO4	4.01e-04	15	69	2	22407294
Pubmed	Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.	LBX1 PAX7	4.01e-04	15	69	2	22932389
Pubmed	dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development.	LBX1 PAX7	4.01e-04	15	69	2	16690754
Pubmed	Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.	PAX7 VSX2	4.01e-04	15	69	2	9230312
Pubmed	Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.	LBX1 PAX7	4.01e-04	15	69	2	17475798
Pubmed	Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state.	SCRIB AQP2	4.57e-04	16	69	2	18177851
Pubmed	Pivotal roles of Fezf2 in differentiation of cone OFF bipolar cells and functional maturation of cone ON bipolar cells in retina.	FEZF2 VSX2	4.57e-04	16	69	2	29559301
Pubmed	Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.	PAX7 VSX2	4.57e-04	16	69	2	9655799
Pubmed	Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb.	LBX1 PAX7	4.57e-04	16	69	2	24927569
Pubmed	Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord.	PAX7 VSX2	4.57e-04	16	69	2	24948600
Pubmed	Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord.	PAX7 VSX2	4.57e-04	16	69	2	11502253
Pubmed	Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1.	PAX7 VSX2	4.57e-04	16	69	2	11239429
Pubmed	Hedgehog signalling in the mouse requires intraflagellar transport proteins.	PAX7 VSX2	4.57e-04	16	69	2	14603322
Cytoband	8q24.3	EPPK1 GPR20 HGH1 TONSL SCRIB OPLAH	2.24e-08	113	70	6	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	EPPK1 GPR20 HGH1 TONSL PSCA SCRIB OPLAH	1.23e-06	355	70	7	chr8q24
GeneFamily	Ankyrin repeat domain containing	NFKB1 SOWAHD TONSL POTEJ ACAP3	4.00e-04	242	47	5	403
GeneFamily	Aquaporins	AQP8 AQP2	5.90e-04	14	47	2	305
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CC2D1B BAIAP3	3.94e-03	36	47	2	823
Coexpression	NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON	EPPK1 GPR20 HGH1 TRPS1 TONSL PSCA SCRIB OPLAH	8.50e-09	157	69	8	M17936
Coexpression	BLANCO_MELO_INFLUENZA_A_INFECTION_A594_CELLS_DN	LMF1 SLC39A1 TONSL SLC25A29 OPLAH	1.52e-05	118	69	5	M34005
Disease	reticulocyte measurement	WIZ GPER1 FNTB NFKB1 SOWAHD TRPS1 IRS1 ZFPM1 TSC22D2 BAIAP3	1.10e-04	1053	66	10	EFO_0010700
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	LMF1 ZNF335 TRPS1 TSC22D2 OPRL1	1.48e-04	224	66	5	EFO_0004530, EFO_0008317
Disease	reticulocyte count	GPER1 FNTB NFKB1 SOWAHD TRPS1 IRS1 ZFPM1 TSC22D2 BAIAP3	5.12e-04	1045	66	9	EFO_0007986
Disease	cutaneous squamous cell carcinoma	TRPS1 HAL	2.49e-03	33	66	2	EFO_1001927
Disease	duodenal ulcer	PSCA OPRL1	2.96e-03	36	66	2	EFO_0004607
Disease	lysine measurement	TINAGL1 SLC25A29	3.12e-03	37	66	2	EFO_0005002
Disease	Alzheimer's disease (is_implicated_in)	IRS1 BACE2 LRP8	3.26e-03	132	66	3	DOID:10652 (is_implicated_in)
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	LMF1 TRPS1 TSC22D2 OPRL1	3.34e-03	274	66	4	EFO_0004530, EFO_0004612
Disease	osteoarthritis, knee	EPPK1 CHADL PAX7	5.39e-03	158	66	3	EFO_0004616

Protein segments in the cluster

Peptide	Gene	Start	Entry
HADGLALALEPALAS	BACE2	56	Q9Y5Z0
AAQLLGAVAGAALLH	AQP2	91	P41181
VLHAADLLPLDANGL	BAIAP3	1031	O94812
LSAGPHALTQALANG	GPR20	341	Q99678
LPALAAALAHGAEVN	ACAP3	681	Q96P50
TDTGLLQPALAHGLA	AQP8	61	O94778
AALAEELGGPVHALA	BOLA1	91	Q9Y3E2
LQHQAALLAAAQGPG	CELF6	251	Q96J87
DFAALAALALALPAG	C17orf113	596	A0A1B0GUU1
AALALALPAGAGLLD	C17orf113	601	A0A1B0GUU1
LGHGSLQPASAAGLA	RAB33A	6	Q14088
AGANQLAAFNHLLPG	PAX7	276	P23759
SLHENGALVPLGDAL	KLHL30	501	Q0D2K2
SGGVLSNLALHPLDL	SLC25A32	31	Q9H2D1
LLAAGLAAHLGTGQP	LRRN2	641	O75325
HTALQGPLASADLGL	ZFPM1	406	Q8IX07
VPILHGAAALADDLA	MPP7	66	Q5T2T1
GLDHNLLASVPAGAF	LRFN3	186	Q9BTN0
GLLGLPGALYAHDAL	ALOX12	451	P18054
GPQGAAELAAHSSLL	IRS1	1046	P35568
GFPHLQLLDVSGNAL	LRRC58	66	Q96CX6
AAAATGPQGLHLLFE	FBRS	326	Q9HAH7
VGASGDLAPLSHLAL	HAL	251	P42357
GGEALHLILLPATGN	CDHR3	16	Q6ZTQ4
ALRDLGQPAAAAGHF	F8A1;	151	P23610
PAAQAGASQGLHALL	CC2D1B	156	Q5T0F9
ADLGAEPAAALALLG	ANGPTL6	126	Q8NI99
NQLFSGLDPHALAGR	CSAD	91	Q9Y600
ALGHDSPLNQFLAGA	SLC25A29	86	Q8N8R3
GNLGLFPGAALLVSH	MBLAC1	121	A4D2B0
GLLPLLHRALHAQGD	FNTB	306	P49356
AAADKHAQGGLPLAG	LBX1	61	P52954
HAQGGLPLAGRALLS	LBX1	66	P52954
HNALSVLAPEALAGL	CHADL	191	Q6NUI6
FLNGNLAGASLSPLH	CDKL5	366	O76039
SGAHALQPAAAILAL	PSCA	86	O43653
LLEHAGEAIPALAAA	IPO4	831	Q8TEX9
LSGHLFPSGLLNAQA	FEZF2	186	Q8TBJ5
LQHLAAAAADPLLGG	LRP8	26	Q14114
NLPAGLSGLAHLAHL	PIDD1	116	Q9HB75
LPGAQDDKAGALAAL	PANX2	26	Q96RD6
AARALVNLAADPGLH	HGH1	81	Q9BTY7
LLLNASHGAFLPLGL	OPRL1	36	P41146
QAGAAALLPLGAAAD	SOX4	241	Q06945
LLPLAGHLALGAQQG	TINAGL1	11	Q9GZM7
LGPAALHALGARLGS	SPATA5L1	31	Q9BVQ7
PNLLLDGQLAAAAAA	TSC22D2	86	O75157
HGALAFPLGLDASLN	TCAF2	241	A6NFQ2
HLGADLHPGDVLLSN	OPLAH	806	O14841
LNLSHPLLGTALANG	GPER1	31	Q99527
LLAQHAAGALGLPDL	EPPK1	2676	P58107
ELLAQHAAGALGLPD	EPPK1	3206	P58107
LLAQHAAGALGLPDL	EPPK1	3741	P58107
LAQHAAGALGLPDLV	EPPK1	4276	P58107
DELLAQHAAGALGLP	EPPK1	4806	P58107
GNALPHATLRLDLAG	POTEJ	831	P0CG39
QLGGLLAAAAVAAPL	PPP1R3G	176	B7ZBB8
LGLAGAHPLDFLLLD	WIZ	661	O95785
AHLALNDVSLQALPG	SCRIB	131	Q14160
GGLTPLHLAALQGHD	SOWAHD	186	A6NJG2
APGALLAAAGLADAA	VPS51	381	Q9UID3
ALLLLHLSPGAAGSS	TRPS1	596	Q9UHF7
QGAHVLALGPLEASA	TEP1	1311	Q99973
APGALLGLGNLTHLS	TLR9	191	Q9NR96
LGAALAESAGPLHQL	SLC39A1	256	Q9NY26
ALLDLSSNHLGPEGL	TONSL	1101	Q96HA7
GHGGPAAAILAANTL	PPM1M	126	Q96MI6
GLAAAAALGSAAHRP	PRRT4	476	C9JH25
RDLHPGNLLLDQAGH	RPS6KL1	411	Q9Y6S9
ALLHPQGFEVALGAH	TMEM187	156	Q14656
APGLALDKAATAAHL	UBR3	21	Q6ZT12
AALDLSHNPLRALGG	TPBGL	121	P0DKB5
LAHSLAAIEALADGP	ZNF335	186	Q9H4Z2
DAALAGNGPVLHLEL	TBC1D2	156	Q9BYX2
AALDGLAPGHLLAAR	VSX2	51	P58304
DAEALSLLAHNPFAG	LMF1	491	Q96S06
GHLLNPGDLVLGFDL	NMD3	366	Q96D46
ALLLDHPNGDGLNAI	NFKB1	641	P19838