Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone binding

JAK2 BAZ2A CHD8 CHD6 TSPYL1 PHC1

7.03e-05265536GO:0042393
GeneOntologyCellularComponentMpp10 complex

IMP4 IMP3

1.82e-053522GO:0034457
DomainBRK

CHD8 CHD6

1.18e-046532SM00592
DomainCOLD_SHOCK

YBX1 YBX3

1.18e-046532PS00352
DomainBRK_domain

CHD8 CHD6

1.18e-046532IPR006576
DomainCold-shock_CS

YBX1 YBX3

1.18e-046532IPR019844
DomainBRK

CHD8 CHD6

1.18e-046532PF07533
DomainCSP

YBX1 YBX3

2.19e-048532SM00357
DomainCold_shock_prot

YBX1 YBX3

2.19e-048532IPR011129
DomainCSD

YBX1 YBX3

2.19e-048532PF00313
DomainCSP_DNA-bd

YBX1 YBX3

2.19e-048532IPR002059
DomainSTART

STARD3 ACOT12

8.10e-0415532PF01852
DomainSTART_lipid-bd_dom

STARD3 ACOT12

8.10e-0415532IPR002913
DomainSTART

STARD3 ACOT12

8.10e-0415532PS50848
Domain-

STARD3 ACOT12

1.92e-03235323.30.530.20
DomainSTART-like_dom

STARD3 ACOT12

1.92e-0323532IPR023393
DomainRho_GTPase_activation_prot

DAB2IP ARHGAP36 ARHGAP27

2.00e-0388533IPR008936
DomainChromo_domain

CHD8 CHD6

2.10e-0324532IPR023780
DomainIQ_motif_EF-hand-BS

DCAF6 SPATA17 MYO1E

2.13e-0390533IPR000048
DomainIQ

DCAF6 SPATA17 MYO1E

2.34e-0393533PS50096
DomainChromo

CHD8 CHD6

2.46e-0326532PF00385
DomainCHROMO_1

CHD8 CHD6

2.85e-0328532PS00598
DomainCHROMO_2

CHD8 CHD6

2.85e-0328532PS50013
DomainSNF2_N

CHD8 CHD6

3.71e-0332532IPR000330
DomainChromodomain-like

CHD8 CHD6

3.71e-0332532IPR016197
DomainSNF2_N

CHD8 CHD6

3.71e-0332532PF00176
DomainChromo/shadow_dom

CHD8 CHD6

3.94e-0333532IPR000953
DomainCHROMO

CHD8 CHD6

3.94e-0333532SM00298
DomainDNA/RNA_helicase_DEAH_CS

CHD8 CHD6

4.43e-0335532IPR002464
DomainBROMODOMAIN_1

BAZ2A BRWD3

4.94e-0337532PS00633
DomainDEAH_ATP_HELICASE

CHD8 CHD6

5.20e-0338532PS00690
DomainBromodomain

BAZ2A BRWD3

5.20e-0338532PF00439
Domain-

RBM26 UNKL

5.75e-03405324.10.1000.10
DomainBROMODOMAIN_2

BAZ2A BRWD3

6.04e-0341532PS50014
DomainBROMO

BAZ2A BRWD3

6.33e-0342532SM00297
DomainBromodomain

BAZ2A BRWD3

6.33e-0342532IPR001487
Domain-

BAZ2A BRWD3

6.33e-03425321.20.920.10
DomainZnF_C3H1

RBM26 UNKL

8.20e-0348532SM00356
Domainzf-CCCH

RBM26 UNKL

8.53e-0349532PF00642
Pubmed

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.

DACT1 DCAF6 YBX1 YBX3 PHC1

9.56e-0711653521282530
Pubmed

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

MRPS30 MRPS21 MRPL38 IMP3

1.92e-065853411543634
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

TDRKH BAZ2A CLK3 IMP4 RBM26 SRP68 CHD8 MRPL38 CHD6 TSPYL1 PDCD7 IMP3

2.00e-061497531231527615
Pubmed

Differential distribution of Y-box-binding protein 1 and cold shock domain protein A in developing and adult human brain.

YBX1 YBX3

2.28e-06253224817634
Pubmed

YB-3 substitutes YB-1 in global mRNA binding.

YBX1 YBX3

2.28e-06253231944153
Pubmed

The Y-box motif mediates redox-dependent transcriptional activation in mouse cells.

YBX1 YBX3

6.83e-0635328530481
Pubmed

Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis.

YBX1 YBX3

6.83e-06353216954378
Pubmed

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.

CHD8 CHD6

6.83e-06353228533432
Pubmed

The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes.

IMP4 IMP3

6.83e-06353212655004
Pubmed

Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.

YBX1 YBX3

6.83e-0635322977358
Pubmed

Genetic Polymorphisms in PRM1, PRM2, and YBX2 Genes are Associated with Male Factor Infertility.

YBX3 PRM1

6.83e-06353229227750
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

MRPS30 PPIG YBX1 CLK3 MRPS21 RBM26 MRPL38 YBX3

1.18e-0571353829802200
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

DAB2IP CACNG8 ELFN1 OTUD7A GRIA3

1.28e-0519753536604605
Pubmed

Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain.

YBX1 YBX3

1.36e-0545327628487
Pubmed

Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.

JAK2 KL

1.36e-05453223389690
Pubmed

Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition.

CACNG8 GRIA3

1.36e-05453236429079
Pubmed

LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.

CACNG8 GRIA3

1.36e-05453229581259
Pubmed

Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoter.

YBX1 YBX3

2.27e-05553216198352
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

PPIG EPPK1 YBX1 CLK3 MRPS21 RBM26 YBX3 IMP3

2.86e-0580753822681889
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

EPPK1 YBX1 RBM26 SRP68 CHD8 TSPYL1

2.98e-0539453627248496
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DAB2IP JAK2 DPH2 DACT1 EPPK1 MYO1E UNKL CHD8 RYR1

4.02e-05110553935748872
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

PPIG CLK3 RBM26 CHD8 PDCD7

4.07e-0525153531076518
Pubmed

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.

CACNG8 GRIA3

4.76e-05753233981040
Pubmed

TARP γ-2 and γ-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area.

CACNG8 GRIA3

4.76e-05753227076426
Pubmed

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

CACNG8 GRIA3

6.34e-05853221172611
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

MRPS30 AARS1 CLK3 RBM26 MRPL38 PDCD7 PHC1

8.12e-0568953736543142
Pubmed

The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins.

YBX1 YBX3

8.15e-0595328871564
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

BAZ2A CHD8 CHD6 PHC1

9.85e-0515753430186101
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

CLK3 MRPS21 RBM26 SRP68 UNKL IMP3 PHC1

1.09e-0472353734133714
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

PPIG BAZ2A SRP68 MRPL38 YBX3

1.47e-0433053533301849
Pubmed

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

YBX1 RBM26 CHD8

1.77e-047153336305789
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

MRPS30 EPPK1 YBX1 MRPL38 YBX3

1.84e-0434653525324306
Pubmed

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.

YBX1 SRP68 CHD8 YBX3

2.35e-0419753432434143
Pubmed

Expression analysis of mammalian mitochondrial ribosomal protein genes.

MRPS30 MRPS21 MRPL38

2.43e-047953332987154
Pubmed

Structure and Function of the Mitochondrial Ribosome.

MRPS30 MRPS21 MRPL38

2.72e-048253327023846
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

MRPS30 YBX1 MRPS21 SRP68 CHD8 MRPL38 YBX3 CHD6

3.36e-04115353829845934
Pubmed

Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.

CACNG8 GRIA3

3.43e-041853218311135
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

MRPS30 TDRKH YBX1 BAZ2A IMP4 MRPS21 MRPL38 YBX3 IMP3

3.94e-04149653932877691
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

PPIG YBX1 BAZ2A CHD8 PHC1

4.05e-0441153535182466
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

EPPK1 YBX1 MRPS21 ANKIB1 MRPL38 YBX3

4.14e-0463953623443559
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

MRPS30 MRPS21 MRPL38 YBX3 TSPYL1

4.33e-0441753536537216
Pubmed

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

YBX1 IMP4 RBM26 MRPL38 YBX3

4.72e-0442553521081503
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

PPIG YBX1 SRP68 YBX3 CHD6 TSPYL1

4.72e-0465553635819319
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

DAB2IP EPPK1 ELFN1 SRP68 GRIA3

4.97e-0443053532581705
Pubmed

Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.

AARS1 YBX1 GRIA3 CHD8

5.53e-0424753430713523
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

YBX1 CLK3 IMP4 SRP68 YBX3 TSPYL1

5.66e-0467853630209976
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

EPPK1 MYO1E YBX1 CLK3 IMP4 SRP68 YBX3

5.69e-0494953736574265
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

EPPK1 MYO1E YBX1 CLK3 IMP4 SRP68 YBX3 IMP3

5.95e-04125753836526897
Pubmed

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.

YBX1 SRP68 YBX3 TSPYL1 PDCD7 CHST7

6.89e-0470453632994395
Pubmed

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.

YBX3 PHC1

7.23e-042653234162889
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

PPIG YBX1 BAZ2A IMP4 SRP68 CHD8 CHD6 IMP3

8.10e-04131853830463901
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

SDHAF1 DPH2 AARS1 IMP4 MRPS21 RBM26 UNKL CHD8

8.46e-04132753832694731
Pubmed

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

MRPS30 YBX1 MRPL38 YBX3

8.95e-0428153426725010
Pubmed

Deep sequencing and proteomic analysis of the microRNA-induced silencing complex in human red blood cells.

YBX1 YBX3

9.01e-042953225681748
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

SRP68 CHD8 CHD6 TSPYL1

9.07e-0428253423667531
Pubmed

FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.

EPPK1 YBX3 TSPYL1

9.97e-0412853328027390
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

YBX1 IMP4 SRP68 YBX3 TSPYL1 PDCD7

1.02e-0375953635915203
Pubmed

The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.

MRPS30 MRPS21

1.03e-033153211279123
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PPIG YBX1 CLK3 SRP68 CHD6 PDCD7 IMP3

1.22e-03108253738697112
Pubmed

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

YBX1 PDCD7

1.24e-033453215146077
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

AARS1 EPPK1 MYO1E YBX1 MRPS21 RBM26 SRP68 YBX3

1.28e-03141553828515276
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

AARS1 DCAF6 EPPK1 YBX1 CHD8 RYR1

1.39e-0380753630575818
Pubmed

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

PPIG YBX1 DSTYK YBX3

1.40e-0331753430997501
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

AARS1 YBX1 BAZ2A CLK3 SRP68 YBX3

1.41e-0380953632129710
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TDRKH DCAF6 BAZ2A NFKBIL1 CHD8 TSPYL1 BRWD3

1.46e-03111653731753913
Pubmed

Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.

DAB2IP PPIG CHD8

1.51e-0314853322898364
InteractionSRSF1 interactions

TDRKH PPIG YBX1 CLK3 IMP4 MRPS21 SRP68 YBX3 IMP3

1.35e-05570529int:SRSF1
InteractionPPIG interactions

PPIG YBX1 CLK3 NFKBIL1 CHD8

1.88e-05127525int:PPIG
Cytoband15q24

CLK3 IMP3

2.71e-042153215q24
Cytoband1p34

DPH2 YBX1

6.34e-04325321p34
GeneFamilyY box binding proteins

YBX1 YBX3

1.29e-053382106
GeneFamilyStAR related lipid transfer domain containing

STARD3 ACOT12

4.44e-0415382759
GeneFamilyMitochondrial ribosomal proteins

MRPS30 MRPS21 MRPL38

6.07e-0479383646
GeneFamilyZinc fingers CCCH-type

RBM26 UNKL

2.45e-033538273
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP36 ARHGAP27

4.94e-0350382721
GeneFamilyX-linked mental retardation|Angiotensin receptors

GRIA3 BRWD3

5.54e-0353382103
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ELFN1 RBM26 RYR1

6.44e-03181383694
Diseaseliver cancer (implicated_via_orthology)

JAK2 ACOT12

1.75e-054512DOID:3571 (implicated_via_orthology)
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD8 CHD6

6.12e-057512DOID:0050834 (implicated_via_orthology)
DiseasePARTINGTON X-LINKED MENTAL RETARDATION SYNDROME

GRIA3 BRWD3

8.15e-058512C0796250
Diseaseleft ventricular diastolic function measurement

SPATA17 MYO1E STARD3

1.13e-0454513EFO_0008204
DiseaseMacrocephaly

CHD8 BRWD3

1.59e-0411512C0221355
DiseaseProstatic Neoplasms

DAB2IP JAK2 DCAF6 BAZ2A STARD3 CHD6

6.55e-04616516C0033578
DiseaseMalignant neoplasm of prostate

DAB2IP JAK2 DCAF6 BAZ2A STARD3 CHD6

6.55e-04616516C0376358
Diseaseresponse to perphenazine

MRPS30 ELFN1

9.27e-0426512GO_0097334
Diseaseallergic disease

JAK2 NFKBIL1 MRPS21 ARHGAP27

1.03e-03258514MONDO_0005271

Protein segments in the cluster

PeptideGeneStartEntry
RESRRRRPYGRLRLE

TBC1D12

161

O60347
QRRYLYERIDGRVRG

CHD8

1171

Q9HCK8
LVLGAVYYCLRRRRR

ELFN1

431

P0C7U0
LRAVSLGQDRYRRRY

BAZ2A

1111

Q9UIF9
DRLPYQRRYRERRDS

CLK3

201

P49761
RLRARRRYLVERARD

DPH2

266

Q9BQC3
FRRYRGAIARKRIRL

ACOT12

311

Q8WYK0
IRRRLENRFYRRISA

BRWD3

1191

Q6RI45
FQYRRRHRQRRRGDV

ANKIB1

766

Q9P2G1
GRREARRTRKYLELY

ADAM33

201

Q9BZ11
RLRSRYLGRREFIQR

DCAF6

26

Q58WW2
RRDSYRDRYNRRRGR

RBM26

161

Q5T8P6
RRVFGRIRRFFSRRR

ARHGAP36

156

Q6ZRI8
MLRREARLRREYLYR

IMP4

1

Q96G21
YHILTRKRIRYRFRR

JAK2

221

O60674
YDLGLRRLRQRRRLR

NRTN

141

Q99748
YYYRLLRRPRLQRQR

DAB2IP

16

Q5VWQ8
SRSRYYRQRQRSRRR

PRM1

11

P04553
RRPRRVIARYRYQQV

GABRQ

366

Q9UN88
FRYLRRQRVDVSRRG

GRIA3

321

P42263
YVGEARRRLERVRRR

PDCD7

231

Q8N8D1
YREELRRRREARGAR

OTUD7A

911

Q8TE49
QRRERRFRRYLSAGR

NFKBIL1

31

Q9UBC1
FGRYRRYLGRLRQNL

DSTYK

31

Q6XUX3
YSDIGRRLQARRFRR

LTB4R

201

Q15722
HRYREQEYRRRGRSR

PPIG

591

Q13427
LRLPSYRFRYRRRSR

CACNG8

261

Q8WXS5
LRRARRGRRENVGLY

DACT1

691

Q9NYF0
QRRYTYERIDGRVRG

CHD6

821

Q8TD26
LRVLRRYRLQRREDY

IMP3

31

Q9NV31
NREGLRYYRRLLERL

KL

166

Q9UEF7
RYYRRLLERLRELGV

KL

171

Q9UEF7
DEYYRRLLRVLRARE

CST2

61

P09228
RGLSYRSLRRRVRRL

RYR1

4306

P21817
YLRRRRRVHRYEESE

MRPS30

156

Q9NP92
VRIQRRWRGYRVRKY

SPATA17

96

Q96L03
RFLRLRYGRQRRRQQ

TMEM229A

176

B2RXF0
YFSEGRRRQLLRRYR

EPPK1

841

P58107
RVAIRPNERYRLLRR

ARHGAP27

26

Q6ZUM4
DVLRIEYLYRRGRRQ

SDHAF1

46

A6NFY7
EYLYRRGRRQLQLLR

SDHAF1

51

A6NFY7
QRYRGYCSRRQRRLR

SRP68

81

Q9UHB9
DFVNVRRIERRRDRY

STARD3

346

Q14849
LRRRYLRLRYEDLVR

CHST7

366

Q9NS84
AADRRRYRRGYYGRR

YBX3

171

P16989
PPQRRYRRNFNYRRR

YBX1

276

P67809
ERLEKYRSFDRYRRR

MRPL38

46

Q96DV4
YILYRRYRESREERL

TDRKH

31

Q9Y2W6
GYVLRRILRRAVRYA

AARS1

321

P49588
RRQRESYERCRRIYN

MRPS21

51

P82921
QYYLLREGVRRARRR

TSPYL1

406

Q9H0U9
QEANYARVRRRGPRR

PHC1

846

P78364
QTLRDRRLYIRCYRE

TTC21A

706

Q8NDW8
RRRRPLRRRDGTFNY

UNKL

61

Q9H9P5
IRVRRAGYAYRRIFQ

MYO1E

616

Q12965