Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutamine N-acyltransferase activity	GLYATL1 GLYATL1B	5.42e-06	2	47	2	GO:0047946
GeneOntologyMolecularFunction	glycine N-acyltransferase activity	GLYATL1 GLYATL1B	5.40e-05	5	47	2	GO:0047961
GeneOntologyMolecularFunction	odorant binding	OR2C1 OR1K1 OR5AK3P OR5G3	2.25e-04	127	47	4	GO:0005549
GeneOntologyMolecularFunction	chemoattractant activity	VEGFD WNT5A VEGFB	2.79e-04	54	47	3	GO:0042056
GeneOntologyMolecularFunction	vascular endothelial growth factor receptor binding	VEGFD VEGFB	7.21e-04	17	47	2	GO:0005172
Domain	PD_growth_factor_CS	VEGFD VEGFB	1.13e-04	7	44	2	IPR023581
Domain	PDGF	VEGFD VEGFB	1.93e-04	9	44	2	PF00341
Domain	PDGF_2	VEGFD VEGFB	1.93e-04	9	44	2	PS50278
Domain	PDGF_1	VEGFD VEGFB	1.93e-04	9	44	2	PS00249
Domain	PDGF/VEGF_dom	VEGFD VEGFB	1.93e-04	9	44	2	IPR000072
Domain	PDGF	VEGFD VEGFB	1.93e-04	9	44	2	SM00141
Domain	MIF4G	NCBP1 EIF4G1	2.41e-04	10	44	2	SM00543
Domain	MIF4G	NCBP1 EIF4G1	2.41e-04	10	44	2	PF02854
Domain	MIF4G-like_typ-3	NCBP1 EIF4G1	2.41e-04	10	44	2	IPR003890
Domain	MIF4-like	NCBP1 EIF4G1	5.59e-04	15	44	2	IPR016021
Domain	-	NCBP1 EIF4G1	5.59e-04	15	44	2	1.25.40.180
Domain	tRNAsynth_Ia_anticodon-bd	GUCY1A2 MARS1	5.59e-04	15	44	2	IPR009080
Domain	-	VEGFD VEGFB	1.09e-02	67	44	2	2.10.90.10
Domain	Cystine-knot_cytokine	VEGFD VEGFB	1.09e-02	67	44	2	IPR029034
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	VEGFD VEGFB	1.76e-04	8	36	2	M710
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	VEGFD VEGFB	1.76e-04	8	36	2	MM14753
Pathway	PID_VEGF_VEGFR_PATHWAY	VEGFD VEGFB	2.82e-04	10	36	2	M137
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	MUC19 NCBP1 XRN2 G6PD MARS1 GLG1 PCLO BRPF1 EIF4G1	1.39e-06	807	48	9	30575818
Pubmed	eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G.	NCBP1 EIF4G1	1.87e-06	2	48	2	16156639
Pubmed	Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy.	GABRG2 HCN1	1.87e-06	2	48	2	24368169
Pubmed	Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap.	NCBP1 EIF4G1	1.87e-06	2	48	2	11340157
Pubmed	The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.	SMG1 NCBP1 XRN2	1.98e-06	18	48	3	25220460
Pubmed	Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.	VEGFD VEGFB	1.12e-05	4	48	2	25435370
Pubmed	Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation.	VEGFD VEGFB	1.12e-05	4	48	2	9684805
Pubmed	A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation.	NCBP1 EIF4G1	1.12e-05	4	48	2	19648179
Pubmed	Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects.	VEGFD VEGFB	1.12e-05	4	48	2	19275959
Pubmed	Secondary Placental Defects in Cxadr Mutant Mice.	VEGFD WNT5A VEGFB	1.19e-05	32	48	3	31338035
Pubmed	Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses.	NCBP1 EIF4G1	1.86e-05	5	48	2	25049393
Pubmed	COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.	VEGFD VEGFB	1.86e-05	5	48	2	16570043
Pubmed	Human INT6/eIF3e is required for nonsense-mediated mRNA decay.	NCBP1 EIF4G1	2.79e-05	6	48	2	17468741
Pubmed	eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells.	NCBP1 EIF4G1	3.90e-05	7	48	2	23665581
Pubmed	Transgenic mouse models in angiogenesis and cardiovascular disease.	VEGFD VEGFB	3.90e-05	7	48	2	10685072
Pubmed	BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.	XRN2 G6PD EIF4G1	6.15e-05	55	48	3	33067418
Pubmed	Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos.	VEGFD VEGFB	6.67e-05	9	48	2	15601856
Pubmed	eIF4G is required for the pioneer round of translation in mammalian cells.	NCBP1 EIF4G1	6.67e-05	9	48	2	15361857
Pubmed	Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.	NCBP1 EIF4G1	6.67e-05	9	48	2	19262567
Pubmed	Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.	NCBP1 XRN2	6.67e-05	9	48	2	22767893
Pubmed	The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.	NCBP1 EIF4G1	8.33e-05	10	48	2	23788676
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	NCBP1 XRN2 IDH3G G6PD MARS1 POLA1 ADGRA3 PCLO EIF4G1	1.26e-04	1425	48	9	30948266
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	GABRG2 SMG1 NCBP1 SCCPDH POTEJ GUCY1A2 ERBIN PCLO EIF4G1	1.37e-04	1442	48	9	35575683
Pubmed	Tbx18 regulates development of the epicardium and coronary vessels.	VEGFD VEGFB	1.68e-04	14	48	2	24016759
Pubmed	At Term, XmO and XpO Mouse Placentas Show Differences in Glucose Metabolism in the Trophectoderm-Derived Outer Zone.	IDH3G G6PD	1.94e-04	15	48	2	28680878
Pubmed	Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.	NCBP1 EIF4G1	2.21e-04	16	48	2	27773672
Pubmed	Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.	VEGFD VEGFB	2.50e-04	17	48	2	16778080
Pubmed	SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.	SMG1 NCBP1	3.49e-04	20	48	2	19417104
Pubmed	Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling.	VEGFD VEGFB	3.85e-04	21	48	2	29487191
Pubmed	Mapping the Genetic Landscape of Human Cells.	NCBP1 XRN2 MARS1 POLA1 EIF4G1	3.88e-04	451	48	5	30033366
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	NCBP1 XRN2 EIF4G1	5.33e-04	114	48	3	31553912
Pubmed	Candidate gene analysis in primary lymphedema.	VEGFD VEGFB	5.48e-04	25	48	2	18564921
Pubmed	Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.	NPHP1 ARHGEF6	5.48e-04	25	48	2	16374509
Pubmed	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	GUCY1A2 ERBIN	6.40e-04	27	48	2	24550280
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	XRN2 ERBIN ARHGEF6 BRPF1 CDH17 EIF4G1	6.60e-04	774	48	6	15302935
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SMG1 NCBP1 XRN2 SCCPDH ERBIN G6PD MARS1 EIF4G1	7.30e-04	1440	48	8	30833792
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	SMG1 NCBP1	7.39e-04	29	48	2	20371770
Pubmed	Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.	NPHP1 WNT5A	7.92e-04	30	48	2	24302887
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	NEO1 ADGRA3 EIF4G1	8.16e-04	132	48	3	26439863
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GABRG2 NEO1 IDH3G ERBIN GLG1 HCN1 PCLO	9.04e-04	1139	48	7	36417873
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2C1 OR5AK3P OR7A5 OR5G3	1.24e-03	340	48	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2C1 OR5AK3P OR7A5 OR5G3	1.24e-03	340	48	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2C1 OR5AK3P OR7A5 OR5G3	1.28e-03	343	48	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2C1 OR5AK3P OR7A5 OR5G3	1.33e-03	346	48	4	14611657
Cytoband	11q12.1	GLYATL1 OR5AK3P GLYATL1B OR5G3	2.51e-05	161	48	4	11q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	GLYATL1 MS4A12 OR5AK3P GLYATL1B OR5G3	3.06e-05	345	48	5	chr11q12
GeneFamily	VEGF family	VEGFD VEGFB	3.63e-05	5	35	2	1267
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KCNAB3 HCN1 ARHGEF6 ADGRA3	2.62e-05	163	47	4	db6b7ce6f7221bb73c5e650ac51cdd5d7ef00675
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KCNAB3 HCN1 ARHGEF6 ADGRA3	2.75e-05	165	47	4	d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	TMEM63C POTEJ HCN1 PCLO	4.03e-05	182	47	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MUC19 GABRG2 HCN1 PCLO	4.39e-05	186	47	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GABRG2 KCNAB3 HCN1 ARHGAP44	4.48e-05	187	47	4	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TMEM63C GABRG2 POTEJ PCLO	4.77e-05	190	47	4	5f1863bce9400b7c932f0e4d0e012ec4e8d7e555
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 HCN1 PCLO ARHGAP44	5.38e-05	196	47	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 HCN1 PCLO ARHGAP44	5.60e-05	198	47	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 HCN1 PCLO ARHGAP44	5.60e-05	198	47	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 HCN1 PCLO ARHGAP44	5.60e-05	198	47	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 HCN1 PCLO ARHGAP44	5.60e-05	198	47	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 HCN1 PCLO ARHGAP44	5.60e-05	198	47	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC17A4 N4BP2L2 WNT5A SLC44A3	5.71e-05	199	47	4	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	GABRG2 HCN1 PCLO ARHGAP44	5.82e-05	200	47	4	48d801219bc771d6c7e151dc88ca4c179988de85
Disease	Generalized Epilepsy with Febrile Seizures Plus	GABRG2 HCN1	7.42e-05	9	43	2	C3502809
Disease	hepatic encephalopathy (biomarker_via_orthology)	GABRG2 G6PD	2.15e-04	15	43	2	DOID:13413 (biomarker_via_orthology)
Disease	Agouti-related protein measurement	ABCA6 CDH17	7.11e-04	27	43	2	EFO_0008016
Disease	autism spectrum disorder	XRN2 GUCY1A2 ARHGEF6	1.53e-03	156	43	3	EFO_0003756

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETQKMVLTNYMFPQQ	ERBIN	416	Q96RT1
PVTQLIMYMDVRIQA	CEACAM18	301	A8MTB9
NLGNVIFMSQVMVQY	ARHGEF6	446	Q15052
TRVLYMFNQMPLNLT	ADGRA3	421	Q8IWK6
MVTVMTNINSAVYQV	CDKL4	351	Q5MAI5
MVVYTPISNLTQQIM	ABCA6	76	Q8N139
PQVESYVLTIMNMVA	ADAMTS7	261	Q9UKP4
VIRVQPNEAVYTKMM	G6PD	391	P11413
MLMNIQTQNKVITYI	OR7A5	81	Q15622
QDLVNYVQSVPRMMQ	KLHL31	266	Q9H511
SLPQVLAQATEMLYM	NCBP1	386	Q09161
TPAIIMNTIDMYNVT	TMEM63C	426	Q9P1W3
MMVIQQKPRQTTLYL	PCLO	3956	Q9Y6V0
LQIQIVPVMQLYVSM	MUC19	926	Q7Z5P9
MFVQTILSYQMQPKI	DRAM2	136	Q6UX65
EYQMVIIRPQKQEMT	GLYATL1	51	Q969I3
VTPMVNPLIYTLRNM	OR2C1	281	O95371
VVIPMENIQNMYSES	POLA1	721	P09884
RYPMIMSQTVYIQLV	OR5AK3P	131	Q8NH89
TVMYTVVTPMLNPII	OR1K1	276	Q8NGR3
MQVMTSPSKNYILSV	GLG1	1136	Q92896
EMVQAIAPINYPQMT	HCN1	631	O60741
QFDVMVMPNLYGNIV	IDH3G	266	P51553
MYVNSIGPVNAINME	GABRG2	96	P18507
EYQMVIIRPQKQEMT	GLYATL1B	51	A0A0U1RQE8
QVMMIPSQISYPASQ	EIF4G1	86	Q04637
SVVRIPRIIVMYMQN	SLC44A3	446	Q8N4M1
QIVIQLPMINNVMYF	CDH17	166	Q12864
YTQQMNLSIAIPAMV	SLC17A4	51	Q9Y2C5
VFYQIMTMRRQPQLL	NPHP1	536	O15259
LYTLIMSQQVCMQLV	OR5G3	131	P0C626
QCTPMQVISMLNELY	GUCY1A2	536	P33402
PMEEIVRAMTYVINQ	KCNAB3	206	O43448
TNMSVLVIPNMYESN	MS4A12	231	Q9NXJ0
YVATPIAMVQAAMTL	SCCPDH	371	Q8NBX0
NPTMVLQVQMLVAEL	SMG1	1941	Q96Q15
MQVTIQNLMPATVYI	NEO1	496	Q92859
NTPAMYVAIQAMLSL	POTEJ	791	P0CG39
QIPNTAIMMATYELV	SLC25A36	291	Q96CQ1
YQDVNKMTPSNMAIV	ARHGAP44	391	Q17R89
VQQIAMEMQLTPFLI	BRPF1	621	P55201
QFMISMPQELQVLVK	ZSCAN5B	91	A6NJL1
SGYVNLQRVQMIMLA	XRN2	381	Q9H0D6
MNNPVQMSEVYIIGA	WNT5A	51	P41221
QVRMQILMIRYPSSQ	VEGFB	96	P49765
VVVNVFMMLYVQLVQ	VEGFD	6	O43915
VNIAALLSVMLQPYM	MARS1	746	P56192
EYQMSISIVMNSVEP	N4BP2L2	536	Q92802