Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainGrowth_fac_rcpt_

FAT1 IGF1R MUC13 LTBP4 LRP1B

4.41e-05156475IPR009030
DomainZnF_U1

ZFHX4 ZNF407 ZFHX3

5.21e-0529473SM00451
DomainZnf_U1

ZFHX4 ZNF407 ZFHX3

5.21e-0529473IPR003604
DomainZINC_FINGER_C2H2_2

ZNF823 ZNF462 ZFAT ZFHX4 CBLL2 ZNF407 ZFHX3 ZFX ZNF574

1.15e-04775479PS50157
DomainZINC_FINGER_C2H2_1

ZNF823 ZNF462 ZFAT ZFHX4 CBLL2 ZNF407 ZFHX3 ZFX ZNF574

1.17e-04777479PS00028
DomainZnf_C2H2-like

ZNF823 ZNF462 ZFAT ZFHX4 CBLL2 ZNF407 ZFHX3 ZFX ZNF574

1.41e-04796479IPR015880
DomainZnf_C2H2

ZNF823 ZNF462 ZFAT ZFHX4 CBLL2 ZNF407 ZFHX3 ZFX ZNF574

1.53e-04805479IPR007087
DomainZnF_C2H2

ZNF823 ZNF462 ZFAT ZFHX4 CBLL2 ZNF407 ZFHX3 ZFX ZNF574

1.57e-04808479SM00355
Domain-

ZNF823 ZNF462 ZFAT ZFHX4 ZNF407 ZFHX3 ZFX ZNF574

2.62e-046794783.30.160.60
Domainzf-C2H2

ZNF823 ZNF462 ZFAT ZFHX4 ZNF407 ZFHX3 ZFX ZNF574

3.01e-04693478PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF823 ZNF462 ZFAT ZFHX4 ZNF407 ZFHX3 ZFX ZNF574

3.04e-04694478IPR013087
DomainEGF_CA

FAT1 LTBP4 LRP1B

1.32e-0386473PF07645
DomainEGF_Ca-bd_CS

FAT1 LTBP4 LRP1B

1.87e-0397473IPR018097
DomainEGF_CA

FAT1 LTBP4 LRP1B

1.98e-0399473PS01187
DomainASX_HYDROXYL

FAT1 LTBP4 LRP1B

2.04e-03100473PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT1 LTBP4 LRP1B

2.40e-03106473IPR000152
DomainFYVE

FYCO1 ZFYVE1

2.41e-0329472PF01363
DomainFYVE

FYCO1 ZFYVE1

2.41e-0329472SM00064
DomainEGF_3

FAT1 MUC13 LTBP4 LRP1B

2.85e-03235474PS50026
DomainEGF

FAT1 MUC13 LTBP4 LRP1B

2.85e-03235474SM00181
DomainZnf_FYVE-rel

FYCO1 ZFYVE1

3.30e-0334472IPR017455
DomainEGF-like_dom

FAT1 MUC13 LTBP4 LRP1B

3.51e-03249474IPR000742
DomainEGF_CA

FAT1 LTBP4 LRP1B

3.58e-03122473SM00179
DomainEGF-like_Ca-bd_dom

FAT1 LTBP4 LRP1B

3.74e-03124473IPR001881
DomainEGF_1

FAT1 MUC13 LTBP4 LRP1B

3.82e-03255474PS00022
DomainZnf_FYVE

FYCO1 ZFYVE1

4.11e-0338472IPR000306
DomainEGF-like_CS

FAT1 MUC13 LTBP4 LRP1B

4.15e-03261474IPR013032
DomainEGF_2

FAT1 MUC13 LTBP4 LRP1B

4.38e-03265474PS01186
DomainZF_FYVE

FYCO1 ZFYVE1

4.55e-0340472PS50178
DomainTSP_1

UNC5A ADAMTSL4

1.10e-0263472PF00090
DomainTSP1

UNC5A ADAMTSL4

1.17e-0265472SM00209
DomainTSP1_rpt

UNC5A ADAMTSL4

1.17e-0265472IPR000884
DomainTSP1

UNC5A ADAMTSL4

1.17e-0265472PS50092
Pubmed

The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers.

ZFHX4 ZFHX3

1.94e-06249210873665
Pubmed

HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage.

HDAC6 CIDEC

1.94e-06249228287402
Pubmed

Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.

HDAC6 CREBBP

5.83e-06349232859943
Pubmed

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.

FAT1 HDAC6

5.83e-06349219033385
Pubmed

Behavioral abnormalities observed in Zfhx2-deficient mice.

ZFHX4 ZFHX3

1.16e-05449223300874
Pubmed

Recruitment of cAMP-response element-binding protein and histone deacetylase has opposite effects on glucocorticoid receptor gene transcription.

HDAC6 CREBBP

1.16e-05449220018896
Pubmed

Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity.

HDAC6 CREBBP

1.94e-05549229259132
Pubmed

Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators.

HDAC6 CREBBP

1.94e-05549223532979
Pubmed

Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.

HDAC6 CREBBP

1.94e-05549235349706
Pubmed

The corepressor activity of Alien is controlled by CREB-binding protein/p300.

TAF1B CREBBP

4.07e-05749223441852
Pubmed

Disruption of FAT10-MAD2 binding inhibits tumor progression.

FAT1 HDAC6

8.69e-051049225422469
Pubmed

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

HDAC6 BBS7

8.69e-051049219081074
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

FAT1 MICAL3 ZSWIM6 IL1R1 ADAMTSL4 KIF24

1.22e-0455249610737800
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 ZFHX4 MCM3AP ZFHX3 CREBBP

1.35e-0435149538297188
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

FAT1 HDAC6 ZFHX4 MCM3AP ZFHX3 LTBP4 CREBBP ZNF574

1.54e-04111649831753913
Pubmed

E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.

MCM3AP LTBP4

2.02e-041549218276110
Pubmed

Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.

ZNF462 ZFHX4

2.30e-041649216096065
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC5A MCM3AP SEL1L3 MICAL3 ZSWIM6

2.67e-0440749512693553
Pubmed

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.

FAT1 IGF1R SLC6A15

3.22e-049449332062451
Pubmed

The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.

ZFHX4 ZFHX3

3.64e-042049235177643
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

ZNF462 ZFHX4 ZFHX3

4.21e-0410349332744500
Pubmed

Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.

OR6C4 OR6C76

5.26e-042449224152035
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

ACSL3 IGF1R PTPRU LRP1B CREBBP STT3A

5.44e-0473049634857952
Pubmed

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

ACSL3 SLC6A15 STT3A

5.52e-0411349330352685
Pubmed

Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes.

IGF1R OTUD7A

6.18e-042649216280085
Pubmed

Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.

HDAC6 CREBBP

7.18e-042849231600191
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FAM20C FAT1 IGF1R MCM3AP MICAL3 FYCO1 LTBP4

8.59e-04110549735748872
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF462 IGF1R SEL1L3 ZFHX3 MICAL3 ZSWIM6 CREBBP STT3A

1.04e-03148949828611215
Pubmed

Tagging genes with cassette-exchange sites.

ZNF462 ZFAT ZSWIM6 CREBBP

1.27e-0333549415741177
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FAT1 IGF1R GNPTAB SEL1L3 SLC6A15 LRP1B STT3A

1.39e-03120149735696571
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX4 ZFHX3

5.17e-0415412529
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF823 ZNF462 ZFAT ZNF407 ZFHX3 ZFX ZNF574

1.05e-0371841728
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

FYCO1 ZFYVE1

2.24e-033141281
GeneFamilyOlfactory receptors, family 6

OR6C4 OR6C76

5.96e-0351412153
GeneFamilyLIM domain containing

MICAL3 FHL5

7.91e-03594121218
ToppCellAdult-Epithelial-club_cell-D175|Adult / Lineage, Cell type, age group and donor

FAT1 SEL1L3 TMC5 IL1R1

4.27e-05177494d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SEL1L3 SLC6A15 ZFHX3 PTPRU

4.56e-05180494b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT1 SEL1L3 TMC5 LRP1B

4.76e-05182494215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 ZFHX4 OTOGL LRP1B

4.97e-05184494ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 ZFHX4 OTOGL LRP1B

4.97e-051844942cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 ZFHX4 OTOGL LRP1B

4.97e-051844942b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBH1 ZNF407 LTBP4 ZNF574

5.07e-0518549460206c7322b4ddb2010040aac70561df842c9843
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FAT1 SEL1L3 MICAL3

5.18e-05186494f28d72b47624b69a580b4429e2be560a26898591
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

OTOGL ZFHX3 LRP1B KIF24

5.18e-0518649423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

FAT1 IGF1R SEL1L3 TMC5

5.29e-05187494ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FAT1 IGF1R MICAL3

5.29e-051874949d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

FAT1 IGF1R SEL1L3 TMC5

5.63e-05190494756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT1 ZFHX3 LTBP4 FHL5

5.74e-051914947853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FAT1 SEL1L3 MICAL3

5.74e-051914941cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FAT1 SEL1L3 DNAI4

5.74e-05191494d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FAT1 ZFHX3 MICAL3 IL1R1

5.98e-05193494e2b455387d1de7812305200a2041a0f4759a6f54
ToppCellSecretory|World / shred by cell class for bronchial biopsy

ACSL3 SEL1L3 MUC13 TMC5

6.22e-0519549452f8281fe0df67cec3faa780a23ed6343ed5a6ba
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 CIDEC LTBP4 LRP1B

6.60e-05198494abac765c4f6864bdb1700bc546c3b9771edc25c3
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 CIDEC LTBP4 LRP1B

6.60e-05198494ff57addcbdd53e5d2d0c80ec76b5eab3b3a67ca2
ToppCell3'-Adult-LymphNode-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZFHX4 CIDEC LTBP4 LRP1B

6.60e-05198494698166b4ca173176ed563af6a1efc8c7d0a18e0b
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

ZNF462 FAT1 ZFHX4 LTBP4

6.86e-05200494a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCellMS-IIF-Lymphocyte-T/NK-ILC|IIF / Disease, condition lineage and cell class

EXD2 DNAI4 MICAL3 ZFYVE1

6.86e-05200494edb0b252e6ff9824908d1ff7d0d42710b00949c8
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ZNF462 FAT1 ZFHX4 LTBP4

6.86e-0520049409537dc25f8b8b4654a7c183827ee1522a41a4e0
Drug(R)-(+)-Atenolol [56715-13-0]; Up 200; 15uM; HL60; HT_HG-U133A

HDAC6 MCM3AP MC3R ZNF407 PTPRU IL1R1

3.63e-061984862496_UP
Diseasepneumonia, COVID-19

FAT1 SLC6A15 FYCO1 LRP1B

2.94e-05113464EFO_0003106, MONDO_0100096
Diseaseatrial fibrillation

ZNF462 ZFAT IGF1R ZFHX4 ZFHX3

2.75e-04371465EFO_0000275
Diseaseserum iron measurement

ZFAT TMC5 LRP1B

3.31e-0486463EFO_0006332
Diseaseobesity (implicated_via_orthology)

HDAC6 ZFHX4 MC3R ZFHX3

3.52e-04215464DOID:9970 (implicated_via_orthology)
Diseasevital capacity

ZFAT IGF1R SLC6A15 ZFHX3 MICAL3 IL1R1 LTBP4 STT3A

5.85e-041236468EFO_0004312
Diseasebody weight

ACSL3 ZFAT IGF1R ZFHX3 ZSWIM6 ZFYVE1 LRP1B ZFX

6.67e-041261468EFO_0004338
Diseasepeak expiratory flow

IGF1R BBS7 MICAL3 ZSWIM6 LTBP4

1.04e-03498465EFO_0009718
DiseaseGlobal developmental delay

ZNF462 IGF1R STT3A

1.18e-03133463C0557874
Diseaselung non-small cell carcinoma (is_implicated_in)

FAT1 ZFHX3 LRP1B

1.34e-03139463DOID:3908 (is_implicated_in)
DiseaseDevelopmental delay (disorder)

IGF1R STT3A

1.53e-0337462C0424605

Protein segments in the cluster

PeptideGeneStartEntry
LFLSASYIYNHYCDC

BBS7

121

Q8IWZ6
YPYYTATCCRSCAHV

ADAMTSL4

1051

Q6UY14
LYFKSCHSCYTYYCS

AJM1

681

C9J069
AYYSYQNRYHFCEKC

CREBBP

1226

Q92793
AFCYHCANLYDKVGY

CBLL2

76

Q8N7E2
YYCKCSALYIGTHCE

FAT1

4036

Q14517
CEYCATTLRLSAYAY

MICAL3

791

Q7RTP6
QYYVCHHYCVNSESC

LRP1B

4321

Q9NZR2
YTCLSHRYGLYVCFL

GNPTAB

11

Q3T906
CEYYFRVYHSLCPIS

COX6B2

56

Q6YFQ2
IFCYYCCNNYVLSKH

FYCO1

1201

Q9BQS8
SASYLNACLLHCYFS

MCM3AP

861

O60318
LLLCTSCHAISNYYD

EXD2

456

Q9NVH0
TACVACRHYYYAGVC

IGF1R

246

P08069
YECLCEAELAQYYSH

KIF24

6

Q5T7B8
AETEHYCSYCYREEL

OTUD7A

901

Q8TE49
FCVSNILNHYYCDYG

OR6C4

166

Q8NGE1
SYDCYVAICKPLHYT

OR6C76

116

A6NM76
VTRCHTYTVSLCYHY

PTPRU

411

Q92729
NCCEEIYTDITYSFY

CHRNA6

221

Q15825
DYPFCVDCYNHLYAN

FHL5

206

Q5TD97
HYNIFYCLYLQENSC

FBH1

406

Q8NFZ0
ICFYGECSYYCSTEH

FAM20C

361

Q8IXL6
NPYCICYTAHFNTYL

MC3R

271

P41968
CSNGYYYHTQRLECI

LTBP4

1281

Q8N2S1
HKCSCSYNEQYLDTY

DNAI4

686

Q5VTH9
YDSVYLHPNSYSCAC

HDAC6

171

Q9UBN7
SGHYYCVVRNSSYCL

IL1R1

91

P14778
SCHEYIDPYLYIASC

OTOGL

331

Q3ZCN5
MAYNSIAYIYHCFCD

OR2AT4

171

A6NND4
ASCVVCYFVALYYNV

SLC6A15

146

Q9H2J7
LTDSSCCGYHKASYY

SEL1L3

561

Q68CR1
RCYCTHVTTYEESNY

TAF1B

521

Q53T94
RFSHRIYVAYCTVYC

STT3A

231

P46977
LVDNICAYANSYHSY

ACSL3

606

O95573
YDTYSLSYDLHCCGA

CIDEC

166

Q96AQ7
CGKAFSCYYYTRLHE

ZNF823

281

P16415
PESCYYYCAVCDYTT

ZFHX4

1016

Q86UP3
REHLYYCSQCHYSSI

ZFAT

766

Q9P243
LHNTSFCLCLEGYYY

MUC13

191

Q9H3R2
YIEHRYVCSECNQLY

ZNF574

11

Q6ZN55
SHLYYCQLEASACYV

UNC5A

556

Q6ZN44
YSHQYDNRVYTCKAC

ZFYVE1

461

Q9HBF4
LQHIISSDLYTNYCY

ZSWIM6

531

Q9HCJ5
HSGRKVYQCEYCEYS

ZFX

741

P17010
DHSAVYRCLECYIDY

ZNF462

881

Q96JM2
IACCAAVYYLAEYNL

TMC5

631

Q6UXY8
DYHFLCKACNLYSLS

ZNF407

731

Q9C0G0
VEGESCYYHCVLCNY

ZFHX3

1081

Q15911