Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	threonine-tRNA ligase activity	TARS3 TARS1	1.06e-05	3	38	2	GO:0004829
GeneOntologyMolecularFunction	co-SMAD binding	USP9Y USP9X	2.30e-04	12	38	2	GO:0070410
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC6A5 SLC6A7	8.70e-04	23	38	2	GO:0005283
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC6A5 SLC6A7 GRIN2B	1.04e-03	105	38	3	GO:0015171
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A5 SLC6A7	1.39e-03	29	38	2	GO:0005416
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC6A5 SLC6A7	2.02e-03	35	38	2	GO:0005343
GeneOntologyBiologicalProcess	threonyl-tRNA aminoacylation	TARS3 TARS1	9.38e-06	3	37	2	GO:0006435
HumanPheno	Cyst of the ductus choledochus	USP9X SUPT16H	5.09e-06	2	12	2	HP:0100890
HumanPheno	Abnormal ductus choledochus morphology	USP9X SUPT16H	3.04e-05	4	12	2	HP:0100889
Domain	ThrRS_core	TARS3 TARS1	1.21e-05	3	38	2	IPR033728
Domain	Thr-tRNA-ligase_IIa	TARS3 TARS1	1.21e-05	3	38	2	IPR002320
Domain	Znf_C2H2-like	ZNF805 ZBTB40 ZBTB34 ZFTA IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	2.37e-05	796	38	9	IPR015880
Domain	ZnF_C2H2	ZNF805 ZBTB40 ZBTB34 ZFTA IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	2.67e-05	808	38	9	SM00355
Domain	-	ZNF805 ZBTB40 ZBTB34 IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	5.44e-05	679	38	8	3.30.160.60
Domain	TGS	TARS3 TARS1	6.02e-05	6	38	2	IPR004095
Domain	TGS	TARS3 TARS1	6.02e-05	6	38	2	PF02824
Domain	zf-C2H2	ZNF805 ZBTB40 ZBTB34 IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	6.28e-05	693	38	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF805 ZBTB40 ZBTB34 IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	6.35e-05	694	38	8	IPR013087
Domain	TGS-like	TARS3 TARS1	8.41e-05	7	38	2	IPR012676
Domain	tRNA_SAD	TARS3 TARS1	8.41e-05	7	38	2	SM00863
Domain	tRNA_SAD	TARS3 TARS1	8.41e-05	7	38	2	IPR012947
Domain	tRNA_SAD	TARS3 TARS1	8.41e-05	7	38	2	PF07973
Domain	Thr/Ala-tRNA-synth_IIc_edit	TARS3 TARS1	1.12e-04	8	38	2	IPR018163
Domain	ZINC_FINGER_C2H2_2	ZNF805 ZBTB40 ZBTB34 IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	1.37e-04	775	38	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF805 ZBTB40 ZBTB34 IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	1.39e-04	777	38	8	PS00028
Domain	HGTP_anticodon	TARS3 TARS1	1.44e-04	9	38	2	PF03129
Domain	Znf_C2H2	ZNF805 ZBTB40 ZBTB34 IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	1.78e-04	805	38	8	IPR007087
Domain	aa-tRNA-synt_IIb	TARS3 TARS1	2.19e-04	11	38	2	IPR002314
Domain	tRNA-synt_2b	TARS3 TARS1	2.19e-04	11	38	2	PF00587
Domain	-	TARS3 TARS1	2.19e-04	11	38	2	3.40.50.800
Domain	Anticodon-bd	TARS3 TARS1	3.61e-04	14	38	2	IPR004154
Domain	Beta-grasp_dom	TARS3 TARS1	3.61e-04	14	38	2	IPR012675
Domain	-	TARS3 TARS1	3.61e-04	14	38	2	3.10.20.30
Domain	aa-tRNA-synth_II	TARS3 TARS1	6.04e-04	18	38	2	IPR006195
Domain	NA_NEUROTRAN_SYMP_2	SLC6A5 SLC6A7	6.04e-04	18	38	2	PS00754
Domain	AA_TRNA_LIGASE_II	TARS3 TARS1	6.04e-04	18	38	2	PS50862
Domain	NA_NEUROTRAN_SYMP_3	SLC6A5 SLC6A7	6.74e-04	19	38	2	PS50267
Domain	SNF	SLC6A5 SLC6A7	6.74e-04	19	38	2	PF00209
Domain	Na/ntran_symport	SLC6A5 SLC6A7	6.74e-04	19	38	2	IPR000175
Domain	NA_NEUROTRAN_SYMP_1	SLC6A5 SLC6A7	6.74e-04	19	38	2	PS00610
Domain	zf-C2H2_6	ZNF805 ZNF556 ZNF763 ZNF440	3.69e-03	314	38	4	PF13912
Domain	KRAB	ZNF805 ZNF556 ZNF763 ZNF440	5.86e-03	358	38	4	PS50805
Domain	KRAB	ZNF805 ZNF556 ZNF763 ZNF440	5.86e-03	358	38	4	PF01352
Pubmed	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.	TARS3 TARS1	1.23e-06	2	39	2	37059185
Pubmed	Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.	IKZF1 IKZF3	1.23e-06	2	39	2	9155026
Pubmed	IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.	IKZF1 IKZF3	1.23e-06	2	39	2	31558666
Pubmed	Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3-ILC1/NK cell transdifferentiation.	IKZF1 IKZF3	1.23e-06	2	39	2	31151137
Pubmed	A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.	IKZF1 IKZF3	1.23e-06	2	39	2	34155405
Pubmed	Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function.	IKZF1 IKZF3	1.23e-06	2	39	2	37662955
Pubmed	A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.	TARS3 TARS1	1.23e-06	2	39	2	29579307
Pubmed	Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus.	IKZF1 IKZF3	1.23e-06	2	39	2	33182226
Pubmed	Critical function of Ikaros in controlling Aiolos gene expression.	IKZF1 IKZF3	1.23e-06	2	39	2	17383641
Pubmed	High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide.	IKZF1 IKZF3	1.23e-06	2	39	2	27881177
Pubmed	Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.	IKZF1 IKZF3	1.23e-06	2	39	2	24509510
Pubmed	Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.	IKZF1 IKZF3	1.23e-06	2	39	2	33499314
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9Y USP9X	1.23e-06	2	39	2	8922996
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9Y USP9X	1.23e-06	2	39	2	12925892
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9Y USP9X	1.23e-06	2	39	2	12895410
Pubmed	Analysis of Ikaros family splicing variants in human hematopoietic lineages.	IKZF1 IKZF3	3.67e-06	3	39	2	20432734
Pubmed	Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.	IKZF1 IKZF3	3.67e-06	3	39	2	27502439
Pubmed	The CD8alpha gene locus is regulated by the Ikaros family of proteins.	IKZF1 IKZF3	3.67e-06	3	39	2	12504015
Pubmed	Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.	IKZF1 IKZF3	3.67e-06	3	39	2	11937265
Pubmed	Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.	TOP3B USP9X	3.67e-06	3	39	2	28101374
Pubmed	Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.	IKZF1 IKZF3	3.67e-06	3	39	2	9560339
Pubmed	Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.	IKZF1 IKZF3	3.67e-06	3	39	2	18332232
Pubmed	The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.	IKZF1 IKZF3	7.34e-06	4	39	2	24292623
Pubmed	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction.	HUWE1 USP9X	7.34e-06	4	39	2	21907705
Pubmed	Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.	HUWE1 USP9X	7.34e-06	4	39	2	20023629
Pubmed	Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).	IKZF1 IKZF3	7.34e-06	4	39	2	24328678
Pubmed	Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.	IKZF1 IKZF3	1.22e-05	5	39	2	10978333
Pubmed	Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.	IKZF1 IKZF3	1.22e-05	5	39	2	10766745
Pubmed	USP9X destabilizes pVHL and promotes cell proliferation.	HUWE1 USP9X	1.83e-05	6	39	2	27517496
Pubmed	Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression.	IKZF1 IKZF3	1.83e-05	6	39	2	20566697
Pubmed	Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies.	HUWE1 USP9X	2.56e-05	7	39	2	36346691
Pubmed	Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells.	IKZF1 IKZF3	2.56e-05	7	39	2	26823144
Pubmed	Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.	IKZF1 IKZF3	2.56e-05	7	39	2	10357820
Pubmed	Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.	IKZF1 IKZF3	4.39e-05	9	39	2	19734904
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9Y USP9X	5.48e-05	10	39	2	9384609
Pubmed	Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.	HUWE1 USP9X	6.70e-05	11	39	2	31570706
Pubmed	Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.	IKZF1 IKZF3	6.70e-05	11	39	2	10204490
Pubmed	The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.	HUWE1 USP9X TARS1	7.07e-05	71	39	3	29346117
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9Y USP9X	8.03e-05	12	39	2	23861879
Pubmed	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.	SUPT6H SUPT16H	8.03e-05	12	39	2	30479348
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	SLC6A5 GRIN2B	9.48e-05	13	39	2	20859245
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	RCHY1 SUPT6H USP9X SUPT16H	1.08e-04	220	39	4	34091597
Pubmed	A molecular dissection of the repression circuitry of Ikaros.	IKZF1 IKZF3	1.11e-04	14	39	2	12015313
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	HUWE1 USP9X	1.11e-04	14	39	2	27626314
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP9Y USP9X	1.27e-04	15	39	2	9827704
Pubmed	Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.	HUWE1 USP9X	1.27e-04	15	39	2	30970248
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	USP9Y USP9X	1.27e-04	15	39	2	14762062
Pubmed	RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.	IKZF1 IKZF3	1.46e-04	16	39	2	30760870
Pubmed	Armc5 deletion causes developmental defects and compromises T-cell immune responses.	ZBTB40 HUWE1	1.65e-04	17	39	2	28169274
Pubmed	Ikaros SUMOylation: switching out of repression.	IKZF1 IKZF3	1.65e-04	17	39	2	15767674
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP9Y USP9X	1.65e-04	17	39	2	23287719
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	USP9Y USP9X	1.85e-04	18	39	2	12023983
Pubmed	Ikaros promotes early-born neuronal fates in the cerebral cortex.	IKZF1 IKZF3	2.07e-04	19	39	2	23382203
Pubmed	The repertoire of solute carriers of family 6: identification of new human and rodent genes.	SLC6A5 SLC6A7	2.54e-04	21	39	2	16125675
Pubmed	Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.	HUWE1 USP9X	2.79e-04	22	39	2	37225996
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	SUPT6H SUPT16H	3.91e-04	26	39	2	33298525
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	IKZF1 LIMK2 IKZF3	4.13e-04	129	39	3	23022380
Pubmed	TopBP1 controls BLM protein level to maintain genome stability.	TOP3B USP9X	4.88e-04	29	39	2	24239288
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	HUWE1 USP9X KAT6A SUPT16H	5.15e-04	332	39	4	37433992
Pubmed	Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.	IKZF1 IKZF3	5.23e-04	30	39	2	24292625
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	HUWE1 TARS1	6.33e-04	33	39	2	26296893
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	HUWE1 SUPT6H CNOT10 SUPT16H	6.83e-04	358	39	4	32460013
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	HUWE1 SUPT6H USP9X TARS1 SUPT16H	7.03e-04	638	39	5	33239621
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ACOT8 HUWE1 TOP3B USP9X PHLPP2 SUPT16H	1.03e-03	1049	39	6	27880917
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	ZBTB40 IKZF1 SUPT6H	1.05e-03	178	39	3	27637333
Cytoband	5q32	SLC6A7 ATOX1	9.79e-04	54	39	2	5q32
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF805 ZBTB40 ZBTB34 IKZF1 IKZF3 ZNF556 ZNF763 ZNF440	1.60e-05	718	30	8	28
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	IKZF1 ZCCHC9 GRXCR1	3.28e-03	181	30	3	694
GeneFamily	Ubiquitin specific peptidases	USP9Y USP9X	3.88e-03	56	30	2	366
Disease	amino acid metabolic disorder (implicated_via_orthology)	TARS3 TARS1	9.17e-06	4	37	2	DOID:9252 (implicated_via_orthology)
Disease	Gastro-enteropancreatic neuroendocrine tumor	IKZF1 IKZF3	1.59e-04	15	37	2	C2930967
Disease	L2 Acute Lymphoblastic Leukemia	IKZF1 IKZF3	1.80e-03	50	37	2	C0023453
Disease	Childhood Acute Lymphoblastic Leukemia	IKZF1 IKZF3	1.95e-03	52	37	2	C0023452
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	IKZF1 IKZF3	2.67e-03	61	37	2	C1961102
Disease	neutrophil percentage of granulocytes	IKZF1 LIMK2 IKZF3	2.91e-03	228	37	3	EFO_0007994
Disease	eosinophil percentage of granulocytes	IKZF1 LIMK2 IKZF3	3.14e-03	234	37	3	EFO_0007996
Disease	multiple sclerosis	IKZF1 LIMK2 IKZF3 EGFL6	6.34e-03	594	37	4	MONDO_0005301
Disease	sciatic neuropathy (biomarker_via_orthology)	GRIN2B RCHY1	6.88e-03	99	37	2	DOID:11446 (biomarker_via_orthology)
Disease	reaction time measurement	LIMK2 GRIN2B ATOX1 RCHY1	9.03e-03	658	37	4	EFO_0008393
Disease	lymphocyte percentage of leukocytes	NR1H3 IKZF1 IKZF3 TBC1D14	9.37e-03	665	37	4	EFO_0007993

Protein segments in the cluster

Peptide	Gene	Start	Entry
ARGYIGEGDMKMHCC	ACOT8	211	O14734
MCGPDMYCFEMHCKH	ADAM5	331	Q6NVV9
YKCFCLSGHMLMPDA	EGFL6	116	Q8IUX8
HLMMAVGFCLGYGCP	ADGRF1	696	Q5T601
MPKHEFSVDMTCGGC	ATOX1	1	O00244
SGGHCPMDTYMRRKC	NR1H3	136	Q13133
GFLPCSVCHGSKMSM	GRXCR1	246	A8MXD5
FCHGCSLLMTGPFMV	LIMK2	71	P53671
ASFRDKCMGPMTHCT	PINLYP	131	A6NC86
MGCHGFRDPFECNMC	IKZF1	481	Q13422
GFGLAECCRDLHMMK	HUWE1	176	Q7Z6Z7
RGFHMECCDPPLTRM	KAT6A	286	Q92794
PCADRGMKRMGHRTC	KLHDC9	306	Q8NEP7
MGCHGFRDPFECNMC	IKZF3	471	Q9UKT9
MLRSKMGKCCRHCFP	POTED	56	Q86YR6
ALKPMNCPGHCLMFA	TARS3	486	A2RTX5
FALKPMNCPGHCLMF	TARS1	406	P26639
MNCPGHCLMFDHRPR	TARS1	411	P26639
FFLMCTRCCMGHRPL	USP9X	1336	Q93008
TLGCCICFFIMGFPM	SLC6A5	606	Q9Y345
KAPGTFHMVHGKCMC	NTN4	281	Q9HB63
MHFGAITCAMGIRFK	SUPT16H	266	Q9Y5B9
RFCRDIHMMLGFKPG	SLC6A7	481	Q99884
HPGFMKTGECLRCMF	CNOT10	281	Q9H9A5
CHMGPKVFMNCAGFL	SUPT6H	1021	Q7KZ85
KPCQMAFFRVDHGLM	TBC1D14	536	Q9P2M4
PFRDMKKGMGCNECT	TOP3B	696	O95985
MVMHSGDGPYKCKFC	ZNF440	191	Q8IYI8
LGCMIRFYGEKPCHM	PHLPP2	131	Q6ZVD8
MMHAGGRPYECKHCG	ZNF556	251	Q9HAH1
MCTRCCMGHRPLLFF	USP9Y	1341	O00507
RCGPCKRMFPVFHAM	TXNDC8	31	Q6A555
FPFAKCFVCGEMGHL	ZCCHC9	181	Q8N567
MLKEGYRCPLCMHSA	RCHY1	176	Q96PM5
MVMHSGDGPYKCKFC	ZNF763	191	Q0D2J5
MVHTGEKPYKCMECG	ZNF805	251	Q5CZA5
DFNPARHGMVCMVCG	ZFTA	116	C9JLR9
DRPFMCKHCLMTFTQ	ZBTB40	861	Q9NUA8
MRLHMGITPFVCKFC	ZBTB34	391	Q8NCN2
FRHCFMGVCSGKPGM	GRIN2B	846	Q13224