Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.69e-104894GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.69e-104894GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.69e-104894GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.84e-095894GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.49e-096894GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.28e-087894GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.55e-088894GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.55e-088894GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.55e-088894GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.57e-089894GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.57e-089894GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.59e-0810894GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.59e-0810894GO:0032052
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.57e-0714894GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.57e-0714894GO:0001758
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.69e-0620894GO:0004303
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.66e-0624894GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.11e-0626894GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.11e-0626894GO:0070402
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.98e-0627894GO:0008106
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.25e-0630894GO:0018455
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.21e-0532894GO:0004033
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.37e-0533894GO:0033764
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4 AKR1C1

1.38e-0511893GO:0030283
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.54e-0534894GO:0016628
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.69e-0539894GO:0016229
GeneOntologyMolecularFunctionlipid binding

SEC14L3 PSAP SEC14L6 PLA2G4B CYTH2 AKR1C3 MYO1B AKR1C4 CPS1 ACBD6 SEC14L4 AKR1C1 AKR1C2 PXK SEC14L2

2.88e-059888915GO:0008289
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.98e-0540894GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.18e-0548894GO:0016620
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.13e-0456894GO:0016903
GeneOntologyMolecularFunctionmonocarboxylic acid binding

PSAP AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.17e-04107895GO:0033293
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

1.17e-044892GO:0047718
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.49e-0460894GO:0016655
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.69e-0462894GO:0016627
GeneOntologyMolecularFunctionNADP binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.69e-0462894GO:0050661
GeneOntologyMolecularFunctionnuclear androgen receptor binding

PRPF6 PIAS2 KDM1A

4.24e-0433893GO:0050681
GeneOntologyMolecularFunctiontestosterone dehydrogenase (NAD+) activity

AKR1C3 AKR1C4

6.93e-049892GO:0047035
GeneOntologyMolecularFunctionDEAD/H-box RNA helicase binding

POT1 SMAD3

6.93e-049892GO:0017151
GeneOntologyMolecularFunctioncarboxylic acid binding

PSAP AKR1C3 AKR1C4 CPS1 AKR1C1 AKR1C2

7.01e-04239896GO:0031406
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.62e-0495894GO:0016651
GeneOntologyMolecularFunctionorganic acid binding

PSAP AKR1C3 AKR1C4 CPS1 AKR1C1 AKR1C2

9.61e-04254896GO:0043177
GeneOntologyMolecularFunctionco-SMAD binding

USP9Y SMAD3

1.26e-0312892GO:0070410
GeneOntologyMolecularFunctionmonooxygenase activity

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.75e-03115894GO:0004497
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

AKR1C3 AKR1C4 AKR1C1 AKR1C2 KDM1A

1.76e-03194895GO:0016705
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.51e-03127894GO:0016616
GeneOntologyMolecularFunctionsteroid binding

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.97e-03133894GO:0005496
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

PLK2 NEK5 NANS CDK11A OAS3 SRPK1 SRPK3 PPIP5K2 KIT PXK DNTT

2.97e-039388911GO:0016772
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.39e-03138894GO:0016614
GeneOntologyMolecularFunctionnuclear glucocorticoid receptor binding

PIAS2 SMAD3

3.54e-0320892GO:0035259
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.69e-104854GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.69e-104854GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.69e-104854GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.69e-104854GO:0008208
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.34e-095854GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.34e-095854GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.34e-095854GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.34e-095854GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.34e-095854GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.34e-095854GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.00e-096854GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.00e-096854GO:0016095
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.31e-097854GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.31e-097854GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.31e-097854GO:1900052
GeneOntologyBiologicalProcessparturition

PLA2G4B AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.63e-0822855GO:0007567
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.33e-089854GO:0044597
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.53e-0810854GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.53e-0810854GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.53e-0810854GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.53e-0810854GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.53e-0810854GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.67e-0811854GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.67e-0811854GO:0016115
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.61e-0714854GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.61e-0714854GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.54e-0715854GO:0016102
GeneOntologyBiologicalProcesstestosterone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.71e-0716854GO:0061370
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.71e-0716854GO:0032351
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.86e-0718854GO:0030656
GeneOntologyBiologicalProcesscellular response to fatty acid

AKR1C3 AKR1C4 CPS1 AKR1C1 AKR1C2

7.96e-0742855GO:0071398
GeneOntologyBiologicalProcessregulation of steroid metabolic process

AKR1C3 DDX20 AKR1C4 KIT AKR1C1 AKR1C2 SEC14L2

1.42e-06135857GO:0019218
GeneOntologyBiologicalProcesshormone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.52e-0621854GO:0042447
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.52e-0621854GO:0016114
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.52e-0621854GO:0048385
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.52e-0621854GO:0042574
GeneOntologyBiologicalProcessketone catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.52e-0621854GO:0042182
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.86e-0622854GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.86e-0622854GO:0042448
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.86e-0622854GO:1902644
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.24e-0623854GO:0071379
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.24e-0623854GO:0034310
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.75e-0626854GO:0010566
GeneOntologyBiologicalProcessregulation of mRNA processing

AKR1C3 CDK11A SRPK1 SRPK3 AKR1C4 AKR1C1 AKR1C2

4.05e-06158857GO:0050684
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

AKR1C3 DDX20 AKR1C4 AKR1C1 AKR1C2 SEC14L2

5.03e-06106856GO:0050810
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.10e-0628854GO:0048025
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.90e-0629854GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.90e-0629854GO:0050686
GeneOntologyBiologicalProcessintracellular receptor signaling pathway

AKR1C3 BIRC2 OAS3 AKR1C4 PIAS2 ZDHHC3 AKR1C1 AKR1C2 KDM1A EPG5

8.13e-064168510GO:0030522
GeneOntologyBiologicalProcesssecondary metabolic process

AKR1C3 AKR1C4 ACMSD AKR1C1 AKR1C2

8.34e-0667855GO:0019748
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.84e-0632854GO:2000353
GeneOntologyBiologicalProcessresponse to fatty acid

AKR1C3 AKR1C4 CPS1 AKR1C1 AKR1C2

9.64e-0669855GO:0070542
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.00e-0533854GO:0033119
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

FBN2 AKR1C3 AKR1C4 LTBP3 USP9Y CDH5 AKR1C1 AKR1C2 SMAD3

1.01e-05336859GO:0071560
GeneOntologyBiologicalProcesssteroid catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.13e-0534854GO:0006706
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

FBN2 AKR1C3 AKR1C4 LTBP3 USP9Y CDH5 AKR1C1 AKR1C2 SMAD3

1.19e-05343859GO:0071559
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.28e-0535854GO:0120255
GeneOntologyBiologicalProcessregulation of endothelial cell apoptotic process

AKR1C3 AKR1C4 CDH5 AKR1C1 AKR1C2

1.36e-0574855GO:2000351
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.43e-0536854GO:0034694
GeneOntologyBiologicalProcessisoprenoid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.43e-0536854GO:0008299
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.78e-0538854GO:0048384
GeneOntologyBiologicalProcessendothelial cell apoptotic process

AKR1C3 AKR1C4 CDH5 AKR1C1 AKR1C2

1.87e-0579855GO:0072577
GeneOntologyBiologicalProcessretinoic acid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-0540854GO:0042573
GeneOntologyBiologicalProcesslipid catabolic process

PSAP LIPM PLA2G4B AKR1C3 AKR1C4 CPS1 PLCH1 AKR1C1 AKR1C2

2.78e-05382859GO:0016042
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.52e-0545854GO:0008207
GeneOntologyBiologicalProcessalcohol catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.19e-0547854GO:0046164
GeneOntologyBiologicalProcessprostaglandin metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.38e-0556854GO:0006693
GeneOntologyBiologicalProcessprostanoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.98e-0557854GO:0006692
GeneOntologyBiologicalProcessketone biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.98e-0557854GO:0042181
GeneOntologyBiologicalProcessregulation of hormone metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.62e-0558854GO:0032350
GeneOntologyBiologicalProcesspositive regulation of epithelial cell apoptotic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.10e-0460854GO:1904037
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

AKR1C3 SRPK1 SRPK3 DDX20 PRPF6 AKR1C4 AKR1C1 AKR1C2

1.15e-04358858GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

AKR1C3 SRPK1 SRPK3 DDX20 PRPF6 AKR1C4 AKR1C1 AKR1C2

1.15e-04358858GO:0000377
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

AKR1C3 SRPK1 SRPK3 DDX20 PRPF6 AKR1C4 AKR1C1 AKR1C2

1.24e-04362858GO:0000375
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

PLA2G4B AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.88e-04128855GO:0033559
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

AKR1C3 AKR1C4 PIAS2 AKR1C1 AKR1C2 KDM1A

1.88e-04202856GO:0141193
GeneOntologyBiologicalProcessregulation of mRNA splicing, via spliceosome

AKR1C3 SRPK1 AKR1C4 AKR1C1 AKR1C2

1.95e-04129855GO:0048024
GeneOntologyBiologicalProcesssteroid biosynthetic process

AKR1C3 DDX20 AKR1C4 AKR1C1 AKR1C2 SEC14L2

2.26e-04209856GO:0006694
GeneOntologyBiologicalProcessorganic hydroxy compound catabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.35e-0473854GO:1901616
GeneOntologyBiologicalProcessicosanoid metabolic process

PLA2G4B AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.04e-04142855GO:0006690
GeneOntologyBiologicalProcessregulation of lipid metabolic process

PSAP AKR1C3 DDX20 AKR1C4 KIT AKR1C1 AKR1C2 SEC14L2

3.13e-04415858GO:0019216
GeneOntologyBiologicalProcesscellular response to corticosteroid stimulus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.51e-0481854GO:0071384
GeneOntologyBiologicalProcessnegative regulation of small molecule metabolic process

AKR1C3 AKR1C4 ACMSD AKR1C1 AKR1C2

3.79e-04149855GO:0062014
GeneOntologyBiologicalProcessregulation of epithelial cell apoptotic process

AKR1C3 AKR1C4 CDH5 AKR1C1 AKR1C2

4.15e-04152855GO:1904035
GeneOntologyBiologicalProcessmRNA processing

AKR1C3 CDK11A SRPK1 SRPK3 DDX20 PRPF6 AKR1C4 AKR1C1 AKR1C2

4.40e-04551859GO:0006397
GeneOntologyBiologicalProcesscellular response to steroid hormone stimulus

AKR1C3 AKR1C4 PIAS2 AKR1C1 AKR1C2 KDM1A

4.63e-04239856GO:0071383
GeneOntologyBiologicalProcesscellular response to calcium ion

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.81e-0488854GO:0071277
GeneOntologyBiologicalProcesspositive regulation of reactive oxygen species metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.02e-0489854GO:2000379
GeneOntologyBiologicalProcessretinoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.02e-0489854GO:0001523
GeneOntologyBiologicalProcesshormone-mediated signaling pathway

AKR1C3 AKR1C4 PIAS2 AKR1C1 AKR1C2 KDM1A

5.17e-04244856GO:0009755
GeneOntologyBiologicalProcessregulation of lipid biosynthetic process

AKR1C3 DDX20 AKR1C4 AKR1C1 AKR1C2 SEC14L2

5.40e-04246856GO:0046890
GeneOntologyBiologicalProcessnegative regulation of lipid biosynthetic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.46e-0491854GO:0051055
GeneOntologyBiologicalProcessditerpenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.18e-0494854GO:0016101
GeneOntologyBiologicalProcessaldehyde metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.43e-0495854GO:0006081
GeneOntologyBiologicalProcessglycosyl compound metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.69e-0496854GO:1901657
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

SLIT2 FBN2 AKR1C3 AKR1C4 LTBP3 CPS1 USP9Y CDH5 AKR1C1 AKR1C2 SMAD3

7.20e-048508511GO:0071363
GeneOntologyBiologicalProcessresponse to estrogen

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.71e-04103854GO:0043627
GeneOntologyBiologicalProcessolefinic compound metabolic process

PLA2G4B AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.94e-04180855GO:0120254
GeneOntologyBiologicalProcesssteroid metabolic process

AKR1C3 DDX20 AKR1C4 KIT AKR1C1 AKR1C2 SEC14L2

9.22e-04376857GO:0008202
GeneOntologyBiologicalProcessterpenoid metabolic process

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.36e-04105854GO:0006721
MousePhenoparturition failure

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.25e-0710714MP:0012010
MousePhenohypermyelination

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.96e-0711714MP:0010050
MousePhenoincreased oligodendrocyte number

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.22e-0713714MP:0010160
MousePhenoincreased circulating progesterone level

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.99e-0715714MP:0005186
MousePhenolong stride length

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.99e-0715714MP:0010540
MousePhenolong gestation period

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.99e-0715714MP:0002293
MousePhenoabnormal gestational length

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.77e-0618714MP:0002292
MousePhenodysmyelination

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.78e-0620714MP:0013438
MousePhenoabnormal oligodendrocyte morphology

PTPRZ1 AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.74e-0651715MP:0000953
MousePhenodecreased oligodendrocyte number

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.13e-0625714MP:0009808
MousePhenoprolonged diestrus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.52e-0530714MP:0009011
MousePhenoabnormal myelination

SH3TC2 PSAP PTPRZ1 AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.06e-05166717MP:0000920
MousePhenoabnormal parturition

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.24e-0533714MP:0002907
MousePhenoabnormal diestrus

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.84e-0535714MP:0009010
MousePhenoenhanced coordination

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.96e-0538714MP:0003858
MousePhenoprolonged estrous cycle

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.39e-0539714MP:0009006
MousePhenoabnormal stride length

PSAP AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.90e-0582715MP:0012690
MousePhenodecreased vocalization

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.49e-0546714MP:0020351
MousePhenostereotypic behavior

PSAP UNC5C AKR1C3 AKR1C4 AKR1C1 AKR1C2 EPG5

1.04e-04214717MP:0001408
MousePhenoabnormal circulating progesterone level

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.18e-0450714MP:0005184
MousePhenoincreased stereotypic behavior

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.48e-0453714MP:0001409
MousePhenoabnormal progesterone level

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.60e-0454714MP:0011384
MousePhenoabnormal glial cell morphology

SH3TC2 PSAP PTPRZ1 AKR1C3 AKR1C4 AKR1C1 AKR1C2 EPG5

3.49e-04345718MP:0003634
MousePhenoabnormal estrous cycle

AKR1C3 DDX20 AKR1C4 AKR1C1 AKR1C2

3.55e-04120715MP:0001927
MousePhenoincreased erythrocyte cell number

AKR1C3 AKR1C4 KIT AKR1C1 AKR1C2

3.98e-04123715MP:0003131
MousePhenoabnormal ovulation cycle

AKR1C3 DDX20 AKR1C4 AKR1C1 AKR1C2

4.45e-04126715MP:0009344
MousePhenoabnormal CNS glial cell morphology

PSAP PTPRZ1 AKR1C3 AKR1C4 AKR1C1 AKR1C2 EPG5

4.49e-04272717MP:0000952
DomainALDOKETO_REDUCTASE_1

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.90e-0810894PS00798
DomainAldo/ket_reductase_CS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.90e-0810894IPR018170
DomainAldo/keto_reductase

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.90e-0810894IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.90e-0810894PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.90e-0810894PS00063
DomainCRAL-bd_toc_tran

SEC14L3 SEC14L6 SEC14L4 SEC14L2

2.32e-0712894IPR001071
DomainCRAL_TRIO_N

SEC14L3 SEC14L6 SEC14L4 SEC14L2

2.32e-0712894SM01100
DomainCRAL/TRIO_N_dom

SEC14L3 SEC14L6 SEC14L4 SEC14L2

6.32e-0715894IPR011074
Domain-

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.39e-07168943.20.20.100
DomainNADP_OxRdtase_dom

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.09e-0617894IPR023210
DomainAldo_ket_red

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.09e-0617894PF00248
DomainAldo/ket_red/Kv-b

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.09e-0617894IPR001395
DomainGOLD_dom

SEC14L3 SEC14L6 SEC14L4 SEC14L2

1.77e-0619894IPR009038
DomainGOLD

SEC14L3 SEC14L6 SEC14L4 SEC14L2

1.77e-0619894PS50866
DomainCRAL_TRIO

SEC14L3 SEC14L6 SEC14L4 SEC14L2

2.71e-0621894PF00650
Domain-

SEC14L3 SEC14L6 SEC14L4 SEC14L2

3.98e-06238943.40.525.10
DomainSEC14

SEC14L3 SEC14L6 SEC14L4 SEC14L2

5.64e-0625894SM00516
DomainCRAL_TRIO

SEC14L3 SEC14L6 SEC14L4 SEC14L2

7.77e-0627894PS50191
DomainCRAL-TRIO_dom

SEC14L3 SEC14L6 SEC14L4 SEC14L2

9.04e-0628894IPR001251
DomainCRAL_TRIO_N

SEC14L3 SEC14L4 SEC14L2

1.68e-0511893PF03765
DomainFAM76

FAM76A FAM76B

2.25e-052892IPR032017
DomainFAM76

FAM76A FAM76B

2.25e-052892PF16046
DomainEMP24_GP25L

SEC14L3 SEC14L4 SEC14L2

4.57e-0515893PF01105
DomainhEGF

SLIT2 FBN2 LTBP3

3.14e-0428893PF12661
DomainTB

FBN2 LTBP3

4.64e-047892PF00683
Domain-

FBN2 LTBP3

6.17e-0488923.90.290.10
DomainTB

FBN2 LTBP3

7.91e-049892PS51364
DomainTB_dom

FBN2 LTBP3

7.91e-049892IPR017878
DomainNTP_transf_2

OAS3 DNTT

1.20e-0311892PF01909
DomainPolymerase_NTP_transf_dom

OAS3 DNTT

1.20e-0311892IPR002934
DomainTumour_necrosis_fac-like_dom

SEC14L3 SEC14L4 SEC14L2

2.67e-0358893IPR008983
Domain-

PMS1 SMCHD1

4.03e-03208923.30.565.10
DomainHATPase_C

PMS1 SMCHD1

4.45e-0321892IPR003594
DomainARM-type_fold

MON2 DOCK1 RTTN NCAPD2 HUWE1 USP9Y

5.63e-03339896IPR016024
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.79e-089644M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.79e-089644M47817
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.24e-0711644M47812
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.68e-0713644M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.68e-0713644MM14747
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.74e-0714644M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.74e-0714644M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.74e-0714644M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.74e-0714644MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.08e-0715644MM14870
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.21e-0623644M1926
PathwayREACTOME_PREDNISONE_ADME

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.21e-0623644MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.21e-0623644MM14741
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.29e-0628644MM15188
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.43e-0533644M5967
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.43e-0533644MM14737
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.58e-0544644M499
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.01e-0545644MM15344
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.01e-0545644MM14751
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.02e-0549644MM15186
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.11e-0455644M14933
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.66e-0461644MM14861
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.83e-0470644M16794
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.00e-0492644MM14881
PathwayREACTOME_FATTY_ACID_METABOLISM

AKR1C3 AKR1C4 ACBD6 AKR1C1 AKR1C2

1.03e-03170645MM15573
PathwayREACTOME_NETRIN_1_SIGNALING

DOCK1 SLIT2 UNC5C

1.03e-0344643M875
PathwayWP_ALTERNATIVE_PATHWAY_OF_FETAL_ANDROGEN_SYNTHESIS

AKR1C4 AKR1C2

1.09e-0311642M39749
PathwayWP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION

AKR1C3 AKR1C1 AKR1C2

1.11e-0345643M39355
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C3 AKR1C4 AKR1C1

1.33e-0348643M27642
PathwayREACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS

AKR1C3 AKR1C4 AKR1C1 AKR1C2 KDM1A

1.73e-03191645MM15586
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491420124700
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491410500239
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491416508162
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491419487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491414967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491410393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491415193432
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491431479646
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491415222881
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491416191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491415577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491410702227
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491417034817
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491417629694
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491429764944
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491410526179
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491417888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491417442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491428329705
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491416018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491417272929
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491419237748
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491418667791
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491428259989
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491421521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-1149148274401
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491416511129
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491410803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-11491434590152
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.38e-1149147789999
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-1059147737980
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-10591421851338
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-10591417872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-10591417064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-10591410672042
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-10591438788959
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-10591416984997
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.19e-10591418003893
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.55e-10691429107092
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.55e-10691419273550
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.55e-10691415860270
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.55e-10691415471942
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.55e-10691426748576
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.55e-10691417122075
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.55e-10691417255200
Pubmed

Functional dynamics of H3K9 methylation during meiotic prophase progression.

AKR1C3 AKR1C4 KIT AKR1C1 AKR1C2

1.24e-091991517599069
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.53e-09791426160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.53e-09791434843575
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.53e-09791422529366
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.53e-09791433127481
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.53e-09791412562828
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.53e-09791416337335
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.04e-09891433584538
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.04e-09891420837989
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.04e-0989149224647
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.47e-09991433348080
Pubmed

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.

NUTM1 AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.91e-092691523892084
Pubmed

Identification of differentially expressed genes in mouse spermatogenesis.

MYO7B AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.46e-092791514581517
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.10e-091091436313771
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C3 AKR1C1 AKR1C2

1.73e-08391319320734
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C3 AKR1C1 AKR1C2

1.73e-08391331780644
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C3 AKR1C4 AKR1C1

1.73e-0839137626489
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C3 AKR1C1 AKR1C2

1.73e-08391321232532
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C3 AKR1C1 AKR1C2

1.73e-08391313678667
Pubmed

Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A.

SEC14L3 SEC14L4 SEC14L2

1.73e-08391315033454
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.14e-081291421256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.14e-081291428893949
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.14e-081291425774556
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.08e-081391411682476
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.08e-081391417062636
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.08e-081391415117747
Pubmed

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.08e-081391424580729
Pubmed

Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.30e-081491419955443
Pubmed

Placental endocrine function shapes cerebellar development and social behavior.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.30e-081491434400844
Pubmed

Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.

SEC14L6 SEC14L4 SEC14L2

6.92e-08491317077281
Pubmed

Cloning of novel human SEC14p-like proteins: ligand binding and functional properties.

SEC14L3 SEC14L4 SEC14L2

6.92e-08491312757856
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.02e-071791432243503
Pubmed

The lipid-binding SEC14 domain.

SEC14L3 SEC14L6 SEC14L2

1.73e-07591317428729
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C3 AKR1C1 AKR1C2

1.73e-07591315212687
Pubmed

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.06e-072091423636947
Pubmed

WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.06e-072091424135228
Pubmed

Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.74e-072391423685333
Pubmed

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.32e-072591426098214
Pubmed

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

AKR1C3 AKR1C1 AKR1C2

6.02e-07791319846565
Pubmed

Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.35e-072791417077188
Pubmed

Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.35e-072791423471215
Pubmed

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.56e-072891429879378
Pubmed

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.56e-072891421820362
Pubmed

The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.56e-072891429212953
Pubmed

Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.49e-063291434288113
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.71e-063791421362171
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

MON2 APEX2 CDK11A ANP32E MYO1B DDX20 HUWE1 PIAS2 KDM1A RPAP2

3.33e-06588911038580884
Pubmed

WT1-mediated gene regulation in early urogenital ridge development.

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.02e-064591418391535
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

FBN2 PTPRZ1 UNC5C AKR1C3 AKR1C4 AKR1C1

6.10e-0617191620201926
Pubmed

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

AKR1C4 AKR1C1

6.77e-0629128172617
Pubmed

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.

AKR1C1 AKR1C2

6.77e-0629128573067
Pubmed

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.

AKR1C3 AKR1C4

6.77e-0629127650035
Pubmed

Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.

AKR1C1 AKR1C2

6.77e-06291211514561
Pubmed

Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.

AKR1C1 AKR1C2

6.77e-06291215492289
Pubmed

Local androgen inactivation in abdominal visceral adipose tissue.

AKR1C3 AKR1C2

6.77e-06291214671194
InteractionAKR1C4 interactions

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.34e-088884int:AKR1C4
InteractionAKR1C1 interactions

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.56e-0620884int:AKR1C1
InteractionSEC14L3 interactions

SEC14L3 SEC14L4 SEC14L2

1.59e-066883int:SEC14L3
InteractionAKR1C3 interactions

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.01e-0537884int:AKR1C3
Cytoband10p15-p14

AKR1C3 AKR1C1 AKR1C2

1.50e-07691310p15-p14
Cytoband22q12.2

SEC14L3 SEC14L6 SEC14L4 SEC14L2

5.65e-065891422q12.2
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.24e-0590914chr10p15
CytobandEnsembl 112 genes in cytogenetic band chr22q12

SEC14L3 SEC14L6 SEC14L4 SEC14L2

1.26e-03235914chr22q12
Cytoband4p15.2

SLIT2 ADGRA3

1.42e-03289124p15.2
GeneFamilySEC14 family|PRELI domain containing

SEC14L3 SEC14L6 SEC14L4 SEC14L2

9.09e-1065241063
GeneFamilyAldo-keto reductases

AKR1C3 AKR1C4 AKR1C1 AKR1C2

8.11e-0815524399
GeneFamilyPhospholipases

PLA2G4B PLD5 PLCH1

2.38e-0442523467
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLA2G4B PLCH1

1.34e-0319522832
CoexpressionIRITANI_MAD1_TARGETS_UP

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.99e-0717904MM826
CoexpressionLIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.31e-0624904MM766
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.56e-0625904MM480
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.33e-0630904MM853
CoexpressionBREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

PLA2G4B AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.70e-0674905MM769
CoexpressionDESCARTES_ORGANOGENESIS_INTERMEDIATE_MESODERM

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.04e-0636904MM3660
CoexpressionWANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.87e-0637904MM630
CoexpressionHOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN

AKR1C3 AKR1C4 AKR1C1 AKR1C2 DNTT

1.13e-0585905MM802
CoexpressionVARELA_ZMPSTE24_TARGETS_DN

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.74e-0545904MM1173
CoexpressionDURCHDEWALD_SKIN_CARCINOGENESIS_UP

AKR1C3 AKR1C4 LTBP3 AKR1C1 AKR1C2

4.11e-05111905MM705
CoexpressionMARSON_FOXP3_TARGETS_DN

AKR1C3 AKR1C4 AKR1C1 AKR1C2

5.47e-0560904MM847
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D

SLIT2 SCAPER AKR1C3 AKR1C4 ZDHHC3 AKR1C1 AKR1C2

6.87e-05293907MM895
CoexpressionNADLER_HYPERGLYCEMIA_AT_OBESITY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.96e-0566904MM631
CoexpressionGOLDRATH_IMMUNE_MEMORY

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.47e-0569904MM621
CoexpressionREICHERT_MITOSIS_LIN9_TARGETS

LMLN NCAPD2 CDK11A

1.21e-0428903MM1323
CoexpressionIVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM

PTPRZ1 SCAPER AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.37e-04228906MM1014
CoexpressionFRASOR_RESPONSE_TO_ESTRADIOL_DN

SLIT2 PLK2 MYO1B SMAD3

1.53e-0478904M3002
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.60e-0479904MM535
CoexpressionLI_ESTROGENE_LATE_E2_RESPONSE_DN

SLIT2 FBN2 UNC5C MYO1B

1.68e-0480904M48218
CoexpressionINGRAM_SHH_TARGETS_UP

FBN2 AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.05e-04156905MM550
CoexpressionAtlasliver

ADRA1A AKR1C4 CFHR5 ACMSD CPS1 USH2A SEC14L4 AKR1C2 ABCC6 SEC14L2

1.13e-054199010liver
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 MYO7B PTPRZ1 UNC5C PLD5 CPS1 USH2A

3.68e-08160907c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 MYO7B PTPRZ1 UNC5C PLD5 CPS1 USH2A

3.68e-0816090725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellEndothelial-H_(cycle)|World / shred on cell class and cell subclass (v4)

NCAPD2 CKAP2L ANP32E KIT CDH5

7.52e-061339058e3005114761feee028c496cc739e607b35d7831
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A PTPRZ1 PLD5 CPS1 KIT

1.44e-051529058ff5a178a8f3550d89a003c0858820aab3773386
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A PTPRZ1 UNC5C PLD5 KIT

1.44e-05152905fed80b467ec9e30c7f98bed6cc4f8c583b715e9e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A PTPRZ1 UNC5C PLD5 KIT

1.68e-05157905516903469756c5fabfdf56d7bd59b3bdd7b44e39
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLPPR4 ADGRB2 TMEM192 OAS3 ADGRA3

2.07e-05164905583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 LIPM KIT ZDHHC3 PXK

2.13e-051659059bd332e5ede759a00a47728ea5558c215efdd77a
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 LIPM OAS3 EVPL TMPRSS11A

2.60e-051729056ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 ADRA1A UNC5C PLD5 TEX15

2.83e-05175905795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A PTPRZ1 SRPK3 PLD5 KIT

2.83e-051759059d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCellBAL-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

FBN2 SMCHD1 OAS3 EVPL MCUB

2.99e-05177905aa021f6d62e9d740c5ea499faaf875de835a2865
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC14L3 TINAG TEX15 ZDHHC3 SEC14L4

3.15e-05179905bf012825e88626e59cd1deebf67c2cd269ce4829
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TINAG ADRA1A MYO7B ACMSD ABCC6

3.15e-05179905d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TINAG MYO7B ACMSD ABCC6 SMAD3

3.15e-0517990558ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 ADRA1A PTPRZ1 SRPK3 PLCH1

3.32e-05181905af92b8b7f455210dab502ef6964f3a0162180759
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

SLIT2 UNC5C AKR1C1 AKR1C2 SMAD3

3.32e-051819052b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_GGT8P|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A PLD5 MCUB KIT ABCC6

3.32e-051819059842537f9a607d8557c43790008d175edab1f32c
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A|E18.5-samps / Age Group, Lineage, Cell class and subclass

NCAPD2 CKAP2L KIT CDH5 CSGALNACT1

3.41e-05182905ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLPPR4 UNC5C CKAP2L PIAS2 PXK

3.50e-051839055377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 MYO7B CPS1 PLCH1 USH2A

3.59e-051849052cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 MYO7B CPS1 PLCH1 USH2A

3.59e-05184905ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 MYO7B CPS1 PLCH1 USH2A

3.59e-051849052b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

SLIT2 TINAG MYO7B ACMSD ABCC6

3.59e-05184905dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 FBN2 PTPRZ1 PLD5 PLCH1

3.69e-05185905f4ac62009c0ad3346e71b809e17727303c4df153
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NUTM1 PTPRZ1 NCAPD2 CKAP2L ANP32E

3.78e-0518690586d145f965c311189e7996390eef491642417c5c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L SLIT2 ADRA1A TEX15 KIT

3.78e-0518690577592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TINAG MYO7B ACMSD PLCH1 ABCC6

3.78e-05186905f28d72b47624b69a580b4429e2be560a26898591
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L ADRA1A PLD5 MCUB KIT

3.78e-05186905310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 TINAG MYO7B ACMSD ABCC6

3.78e-051869058287146f0ba415ea04475588117d4668ae00f75c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 ADRA1A PTPRZ1 PLD5 PLCH1

3.88e-05187905d413fb4b1531b297af5012a392b88128510c2de8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 TINAG MYO7B ACMSD ABCC6

3.88e-0518790571eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

TINAG MYO7B AKR1C3 ACMSD AKR1C1

3.88e-05187905d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLK2 OAS3 KIT CDH5 CSGALNACT1

3.88e-05187905dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

SLIT2 TINAG MYO7B ACMSD AKR1C1

3.88e-05187905acd305475f3609800af0d7bc68d83ef41228080b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L ADRA1A PLD5 MCUB KIT

3.98e-051889050501a8aa850bd2e347020abd1cac4d8075738189
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L ADRA1A PLD5 MCUB KIT

3.98e-05188905433a25fe52914e07e7ba695881f9bcca2d9467ff
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 ADRA1A FBN2 TEX15 KIT

3.98e-051889054544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

FBN2 PTPRZ1 UNC5C CSGALNACT1 ADGRA3

3.98e-051889057b1e3f8a941eaa68e89c562129a92314642eec66
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L ADRA1A PLD5 MCUB KIT

4.08e-05189905f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 ADRA1A FBN2 TEX15 KIT

4.19e-0519090559720dfe9de1b980807644536c919d2a02ba69dd
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L ADRA1A PLD5 MCUB KIT

4.29e-051919057b386512284dfaa0e95358b28ee82632ee965e64
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GREB1L ADRA1A PLD5 MCUB KIT

4.29e-05191905fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PLK2 PTPRZ1 AKR1C3 AKR1C1 AKR1C2

4.40e-051929055d24bb6c6c17a6b803b241d065b31896a7d86c37
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PLK2 PTPRZ1 AKR1C3 AKR1C1 AKR1C2

4.40e-05192905c6795ceba90f1a5d441dff92a737b9c7d28b06b0
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

SLIT2 UNC5C AKR1C1 AKR1C2 SMAD3

4.74e-051959056a02ebbeb3199447ddce64d92d8809436e040eba
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD2 CKAP2L ANP32E KIT CDH5

4.85e-051969050644bd14a944b9c9759a295dfdd5e67a4775f20a
ToppCellRA-02._Fibroblast_II|World / Chamber and Cluster_Paper

SLIT2 UNC5C AKR1C1 AKR1C2 SMAD3

4.85e-05196905e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD2 CKAP2L ANP32E KIT CDH5

4.97e-05197905a41420d4b6d502c2f594c054c7efbb5d4eac83ff
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD2 CKAP2L ANP32E KIT CDH5

4.97e-051979051c89d6836eed30c50c765f7dde9cc8ee15c363d2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBN2 AKR1C3 EVPL AKR1C1 AKR1C2

4.97e-051979059ee927d005eb17843e2516c8006eb192c6ad2af8
ToppCellControl-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

SH3TC2 MCUB AKR1C1 AKR1C2 SMAD3

4.97e-0519790564cc5f61c88e9560b0f8f6f3151255dffb5c3d66
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBN2 AKR1C3 EVPL AKR1C1 AKR1C2

5.09e-051989053371276410dba693c238b383d990b89371b14d8d
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

FBN2 PLA2G4B AKR1C3 MYO1B LTBP3

5.09e-0519890585f424cd9bb3117c9e322031024aabb87696ce47
ToppCellControl_saline-Epithelial_alveolar-AT_1|Control_saline / Treatment groups by lineage, cell group, cell type

FBN2 AKR1C3 MYO1B LTBP3 SEC14L2

5.09e-051989059b161285df7a4e51618f3517cfc5b8221ba55786
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MON2 SMCHD1 RTTN CDK11A USP9Y

5.22e-05199905f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2--L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 FBN2 PTPRZ1 PLD5 PLCH1

5.34e-052009053cbb01039d1e7635ec4dcdf0223587f7ea3c7b34
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 ADRA1A PTPRZ1 PLD5 PLCH1

5.34e-052009051276bfa911fddada4235e12e3081baa53164574b
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-LGR5--L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 ADRA1A PTPRZ1 SRPK3 PLCH1

5.34e-052009058c1d4fffa5abe89ee2ff84fed2dfa97c779bde04
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-LGR5-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 ADRA1A PTPRZ1 SRPK3 PLCH1

5.34e-052009051026b4ede4ea61d01ea942164b37a08c8c8234ff
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 FBN2 PTPRZ1 PLD5 PLCH1

5.34e-0520090597a010a1b6d551239cf6ea5a43319fb413ff180e
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR|Neuronal / cells hierarchy compared to all cells using T-Statistic

GREB1L ADRA1A PLD5 MCUB KIT

5.34e-05200905862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1|Neuronal / cells hierarchy compared to all cells using T-Statistic

GREB1L ADRA1A PLD5 MCUB KIT

5.34e-05200905a91345f268f13170c27309333603eb82400c9947
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 FBN2 PTPRZ1 PLD5 PLCH1

5.34e-052009058ccf2dbbe34b26fbf2bbef1e64b4ae636edd6672
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GREB1L ADRA1A PLD5 MCUB KIT

5.34e-05200905d416a7be1a4e6232fb58a9687774da24821f1fdd
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-LGR5|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 ADRA1A PTPRZ1 SRPK3 PLCH1

5.34e-0520090572c9cd872074b60f62685a95eab83c41e609eb6e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Tmem182|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A FBN2 PLD5 CPS1

1.17e-04124904690595d710b57b7cff8029a3bb06a8dd7e3c03c1
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLD5 CFHR5 ACMSD CSGALNACT1

1.58e-0413490464979e1a056b7406e1be39c5ebe2f8d731ac3c17
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NUTM1 SEC14L6 PTPRZ1 AKR1C1

1.76e-041389042e46d546ad962aa0fde5b1c18c2a5370a4424e9f
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SEC14L3 FBN2 PLD5 CDH5

1.97e-04142904e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 PLCH1 KIT PXK

2.08e-04144904cc11cce43d1af8ac63140d05faf215ae9a10cde1
ToppCellBAL-Control-cDC_4|Control / Compartment, Disease Groups and Clusters

FAM76A PIAS2 AKR1C2 ADGRA3

2.13e-041459043b2a2965dc18abd39d5ed70c0fcad0210e7f12c8
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPS1 USP9Y USH2A TMPRSS11A

2.13e-0414590496712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A PTPRZ1 CPS1 KIT

2.31e-041489045e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TINAG PLCH1 KIT USH2A

2.37e-04149904cc911b454fe4e4b489885b9920baa7eb01a027ba
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 KIT ZDHHC3 PXK

2.43e-0415090487968ce885a4959616f0321f58517fe8029ba1b1
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NUTM1 WDR5B RTTN ADGRB2

2.89e-04157904410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A UNC5C PLD5 KIT

3.03e-041599040dccc4275b9b4f8554dd556da7218e130bff8fd1
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CPS1 USP9Y USH2A TMPRSS11A

3.25e-04162904bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellControl-Epithelial-Ionocyte|Control / Disease state, Lineage and Cell class

SEC14L3 PLK2 WDR5B KIT

3.33e-04163904bf09fa39bf3e6b3a776d5e79c30c96df572956a3
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A UNC5C PLD5 KIT

3.33e-04163904bba830a302919c8b33f914a8839877fc21dd28a0
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A UNC5C PLD5 KIT

3.33e-041639048d17f44faf0549fe71a9a45f811f50d767275414
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADRA1A UNC5C PLD5 KIT

3.41e-0416490408819970174a3eb4eee8e1e675075828665b845e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

UNC5C SI MYO1B PLD5

3.41e-04164904f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FBN2 AKR1C3 AKR1C1 AKR1C2

3.41e-0416490481c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCelldroplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLPPR4 NEK5 NCAPD2 CKAP2L

3.49e-0416590496f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRZ1 PLD5 AKR1C1 AKR1C2

3.57e-041669041df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRZ1 PLD5 AKR1C1 AKR1C2

3.57e-041669049628522e7af8f8edca733588a364ab2454ac5ca5
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTTN NCAPD2 ADGRB2 SEC14L2

3.57e-0416690421ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLIT2 FBN2 PLCH1 ADGRA3

3.65e-0416790455c3c68af269fcf40f2b080ae4489523609ad388
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Syt6-Excitatory_NeuronSlc17a7-Slc17a6.Syt6-Nnat_(Deep_layer_pyramidal_cells--medial_cortex)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PLA2G4B OAS3 DNTT

3.69e-0469903de297aa59c70f15c55cb9570439dc6d3fd6c182b
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Syt6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PLA2G4B OAS3 DNTT

3.69e-046990331f4fb56dfa5e3ad7c83e0770960c3617e4f66a7
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSAP NCAPD2 CKAP2L ANP32E

3.73e-04168904b7cd33f5da4f37b9384fc3bd3ca01fbc790accfc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 UNC5C PLD5 TEX15

3.73e-041689044b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 KIT ZDHHC3 PXK

3.82e-041699042a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PSAP NCAPD2 CKAP2L ANP32E

3.82e-041699044db49b7eaea34e6558ee73b01e76315e99cc880b
ToppCellClub_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

PLK2 AKR1C1 AKR1C2 SMAD3

3.82e-0416990403b303af8a26c6ff196507fe24f5bd3d75d7b1af
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

SLIT2 UNC5C AKR1C1 AKR1C2

3.82e-041699046373562ab3b1765060212a6a53d6543e7e942e80
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 NEK5 SRPK1 AKR1C1

3.82e-041699048f397cf4f9fd7c6fa88d01a95289ce2a6bc6938d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A PTPRZ1 PLD5 KIT

3.90e-0417090436dbbdb13f69307afd2122ff051b2980850c1f00
DrugPregnanes

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.08e-104884ctd:D011278
Drugtetralol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.08e-104884ctd:C019106
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.08e-104884ctd:C018156
Drugcloxazolam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.08e-104884ctd:C005522
DrugHydroxysteroids

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.04e-095884ctd:D006914
Drugcresolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.04e-095884ctd:C010092
DrugMedazepam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

3.11e-096884ctd:D008472
DrugNitrazepam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.44e-088884ctd:D009567
Drug4-hydroxybenzoic acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.59e-089884ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.59e-089884ctd:D004092
Drugoctyl gallate

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.30e-0810884ctd:C016627
Drugcyclopentanone

AKR1C3 AKR1C1 AKR1C2

5.58e-083883ctd:C007201
Drug5-dihydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

5.58e-083883ctd:C454687
Drug4-benzoylbenzoic acid

AKR1C3 AKR1C1 AKR1C2

5.58e-083883ctd:C058818
Drugcyclopentanol

AKR1C3 AKR1C1 AKR1C2

5.58e-083883ctd:C016327
Drugdichloro(4-cymene)ruthenium(II)

AKR1C3 AKR1C1 AKR1C2

5.58e-083883ctd:C530610
DrugDihydroxydihydrobenzopyrenes

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.73e-0811884ctd:D004101
Drugchlordecone alcohol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.73e-0811884CID000013946
DrugPhenolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.01e-0712884ctd:D020113
DrugDMBA-3,4-dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.45e-0713884CID000050096
Drugflunisolide

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.45e-0713884ctd:C007734
Drug1-acenaphthenol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.02e-0714884CID000022750
Drug5-alpha-Dihydroprogesterone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.02e-0714884ctd:D043582
DrugMeclofenamic Acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.02e-0714884ctd:D008469
Drugtetrahydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

2.23e-074883ctd:C009413
Druggliquidone

AKR1C3 AKR1C1 AKR1C2

2.23e-074883ctd:C010969
DrugDBD-H

AKR1C3 AKR1C4 AKR1C1

2.23e-074883CID000131382
DrugNSC86000

AKR1C3 AKR1C1 AKR1C2

5.55e-075883CID000257630
Drugoxcarbazepine

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.72e-0719884ctd:C036006
Drugbenzo(a)pyrene-7,8-dione

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.63e-0720884ctd:C076588
DrugChrysenes

AKR1C3 AKR1C4 AKR1C1 AKR1C2

9.63e-0720884ctd:D002911
DrugAC1L93E5

AKR1C3 AKR1C4 AKR1C1

1.11e-066883CID000412383
Drugacenaphthene-1-ol

AKR1C3 AKR1C1 AKR1C2

1.11e-066883ctd:C023723
DrugEstazolam

AKR1C3 AKR1C1 AKR1C2

1.11e-066883ctd:D004949
Drug3-hydroxyhexobarbital

AKR1C3 AKR1C4 AKR1C2

1.11e-066883CID000439898
DrugGlipizide

AKR1C3 AKR1C1 AKR1C2

1.11e-066883ctd:D005913
DrugFlunitrazepam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.19e-0621884ctd:D005445
Drugbenzene dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.44e-0622884CID000000418
Drug4-hydroxyequilenin-o-quinone

AKR1C3 AKR1C1 AKR1C2

1.93e-067883ctd:C117714
Drugzomepirac

AKR1C3 AKR1C1 AKR1C2

1.93e-067883ctd:C020549
DrugGlycyrrhetinic Acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.09e-0624884ctd:D006034
DrugPregnanolone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.48e-0625884ctd:D011280
Drug9,10-phenanthrenequinone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.48e-0625884ctd:C005399
Drug2-cyclohexen-1-ol

AKR1C3 AKR1C4 AKR1C2

3.08e-068883CID000013198
Drug3,4-dichloroaniline

PLK2 PTPRZ1 AKR1C3 ANP32E PLD5 AKR1C1 AKR1C2

4.54e-06171887ctd:C014464
Drugbenzo(a)pyrene 7,8-dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.05e-0631884ctd:C017228
DrugVitamin E

SEC14L3 SEC14L4 SEC14L2

6.57e-0610883DB00163
Drugfenamic acid

AKR1C3 AKR1C1 AKR1C2

1.20e-0512883ctd:C001209
Drugalpha-methylcinnamic acid

AKR1C3 AKR1C1

1.48e-052882ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

1.48e-052882DB07768
Drugbaccharin

AKR1C3 AKR1C2

1.48e-052882ctd:C012764
Drug4-formyl-benzoate

AKR1C4 AKR1C1 AKR1C2

1.55e-0513883CID000012088
Drug20 alpha-dihydroprogesterone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.71e-0540884CID000008956
Drugo-quinone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.89e-0541884CID000011421
DrugDydrogesterone

AKR1C3 AKR1C1 AKR1C2

1.97e-0514883ctd:D004394
Drug6-.beta.-Naltrexol

AKR1C4 AKR1C1 AKR1C2

1.97e-0514883CID000631219
Drugdrospirenone

AKR1C4 AKR1C1 AKR1C2

2.45e-0515883ctd:C035144
DrugFlufenamic Acid

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.75e-0545884ctd:D005439
Drugnaphthalene-1,2-dihydrodiol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.75e-0545884CID000000362
Drugcaffeic acid phenethyl ester

CYTH2 SCAPER AKR1C3 BIRC2 AKR1C4 PIAS2 AKR1C1 AKR1C2

2.76e-05311888ctd:C055494
Drug9-cis-retinal

AKR1C3 AKR1C4 AKR1C1

3.01e-0516883ctd:C031390
Drug2-nitrobenzaldehyde

FBN2 AKR1C4 AKR1C1

3.01e-0516883CID000011101
DrugOcta

ABRA AKR1C3 AKR1C4 SEC14L2

3.56e-0548884CID000010213
Drugbenzo(a)pyrene-1,6-quinone

AKR1C3 AKR1C1 AKR1C2

3.65e-0517883ctd:C030233
Drugcloxazolam

AKR1C3 AKR1C1 AKR1C2

4.37e-0518883CID000002816
Drugbenzo(a)pyrene-3,6-quinone

AKR1C3 AKR1C1 AKR1C2

4.37e-0518883ctd:C018003
DrugRuthenium Compounds

AKR1C3 AKR1C1 AKR1C2

4.37e-0518883ctd:D017975
Drugandrostane-3,17-dione

AKR1C3 AKR1C4 AKR1C1 AKR1C2

4.53e-0551884CID000000443
DrugAC1L8ZBW

AKR1C4 AKR1C1 AKR1C2

5.17e-0519883CID000435356
DrugHexestrol

AKR1C3 AKR1C4 AKR1C1 AKR1C2

6.11e-0555884ctd:D006589
Drug1,2-dihydroxynaphthalene

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.04e-0557884CID000011318
Drugconiferaldehyde

AKR1C3 AKR1C1 AKR1C2

7.06e-0521883ctd:C075384
DrugDutasteride

AKR1C3 AKR1C1 AKR1C2

7.06e-0521883ctd:D000068538
Drugphenolphthalein

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.54e-0558884CID000004764
DrugNSC36919

AKR1C3 AKR1C4 AKR1C1 AKR1C2

7.54e-0558884CID000235496
DrugSalmfamide 1

ABRA FBN2

8.82e-054882CID005487416
Drugwortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A

SLIT2 TTC23 SCAPER AKR1C3 SMAD3 RPAP2

9.31e-051898867002_UP
Drug2'-Monophosphoadenosine 5'-Diphosphoribose

AKR1C3 AKR1C1 AKR1C2

9.34e-0523883DB03461
Drugmedazepam

AKR1C3 AKR1C1 AKR1C2

1.06e-0424883CID000004041
DrugAlthiazide [5588-16-9]; Up 200; 10.4uM; HL60; HT_HG-U133A

PLK2 PLPPR4 OAS3 TEX15 ABCC6 SMAD3

1.07e-041948862527_UP
DrugLisinopril [83915-83-7]; Up 200; 9uM; MCF7; HT_HG-U133A

GREB1L SLIT2 SCAPER MYO1B PLCH1 SMAD3

1.11e-041958867403_UP
Drugchlordecone

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.33e-0467884CID000000299
Drugglycolithocholic acid

AKR1C3 AKR1C4 AKR1C2

1.36e-0426883CID000115245
Drugfarnesal

AKR1C3 AKR1C2

1.47e-045882ctd:C084519
Drug5 beta-pregnane-3,20-dione

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.75e-0472884CID000092745
DrugDiazepam

AKR1C3 AKR1C4 AKR1C1 AKR1C2

1.95e-0474884ctd:D003975
DrugAC1NBT2J

PSAP AKR1C1 ABCC6

2.55e-0432883CID003958805
DrugNAD

AKR1C3 ACMSD AKR1C1 AKR1C2

2.63e-0480884ctd:D009243
DrugBudesonide

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.63e-0480884ctd:D019819
Drug1,10-phenanthroline

AKR1C3 AKR1C4 AKR1C1 AKR1C2

2.90e-0482884ctd:C025205
Drugtetrahydrozoline

NUTM1 ABCC6

3.06e-047882CID000005419
Drugestazolam

AKR1C3 AKR1C1 AKR1C2

3.34e-0435883CID000003261
Drugquercitrin

AKR1C4 AKR1C1 AKR1C2

3.63e-0436883CID005280459
DiseaseNeoplasms, Hormone-Dependent

AKR1C3 AKR1C1 AKR1C2

2.48e-083873C0027661
DiseaseAmbiguous Genitalia

AKR1C3 AKR1C1 AKR1C2

2.47e-075873C0266362
DiseasePseudohermaphroditism

AKR1C3 AKR1C1 AKR1C2

2.47e-075873C0033804
DiseaseHermaphroditism

AKR1C3 AKR1C1 AKR1C2

2.47e-075873C0019269
DiseaseIntersex Conditions

AKR1C3 AKR1C1 AKR1C2

2.47e-075873C2930618
DiseaseSex Differentiation Disorders

AKR1C3 AKR1C1 AKR1C2

2.47e-075873C2930619
DiseaseDisorders of Sex Development

AKR1C3 AKR1C1 AKR1C2

8.59e-077873C0036875
DiseaseMALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE

AKR1C4 AKR1C2

8.59e-062872C1839840
Diseaselaryngeal squamous cell carcinoma, hypopharynx cancer

RTTN AKR1C1

8.59e-062872EFO_0006352, EFO_0007321
Disease46,XY SEX REVERSAL 8

AKR1C4 AKR1C2

8.59e-062872614279
Disease46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

AKR1C4 AKR1C2

8.59e-062872cv:C1839840
Disease46,XY sex reversal 8 (is_implicated_in)

AKR1C4 AKR1C2

8.59e-062872DOID:0111773 (is_implicated_in)
Diseasecortolone glucuronide (1) measurement

AKR1C3 AKR1C2

1.28e-046872EFO_0800552
DiseaseDegenerative polyarthritis

LTBP3 AKR1C1 AKR1C2 SMAD3

1.69e-0493874C0029408
DiseaseOsteoarthrosis Deformans

LTBP3 AKR1C1 AKR1C2 SMAD3

1.69e-0493874C0086743
DiseaseProstatic Cancer, Castration-Resistant

AKR1C3 KDM1A

3.05e-049872C3658266
DiseaseProstatic Neoplasms, Castration-Resistant

AKR1C3 KDM1A

3.05e-049872C3658267
Diseasefree androgen index

SMCHD1 AKR1C3 AKR1C4 CPS1 PPIP5K2 AKR1C2

8.49e-04374876EFO_0007005
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

1.00e-0316872GO_0031427
Diseasetriacylglycerol 50:5 measurement

MYO1B PLD5

1.00e-0316872EFO_0010412
DiseaseEndometrial Carcinoma

PMS1 AKR1C3 AKR1C1

1.27e-0372873C0476089
Diseasealpha-tocopherol measurement

USH2A SEC14L2

1.58e-0320872EFO_0007898
DiseaseOsteoarthritis of hip

LTBP3 SMAD3

1.58e-0320872C0029410
DiseaseLeft Ventricle Remodeling

ADRA1A SMAD3

1.74e-0321872C0600520
DiseaseVentricular Remodeling

ADRA1A SMAD3

1.74e-0321872C0600519
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

ADRA1A AKR1C3

1.74e-0321872DOID:11612 (biomarker_via_orthology)
Diseasecervical squamous cell carcinoma (is_marker_for)

BIRC2 SMAD3

1.91e-0322872DOID:3744 (is_marker_for)
Diseaseresponse to radiation

TINAG SMCHD1 EPG5

2.27e-0388873GO_0009314
DiseaseLynch syndrome (is_implicated_in)

PMS1 SMAD3

2.27e-0324872DOID:3883 (is_implicated_in)
DiseaseLewy body dementia, Lewy body dementia measurement

ABRA POT1

2.67e-0326872EFO_0006792, EFO_0006799
Diseasemultisite chronic pain

PLK2 ADGRB2 DDX20

2.82e-0395873EFO_0010100
Diseaseretinitis pigmentosa (implicated_via_orthology)

USH2A EPG5

2.88e-0327872DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KAAAGEIIYNKCPPN

ADGRB2

546

O60241
ILNKPGLKYKPVCNQ

AKR1C4

176

P17516
KLHKNDYGIQPNCPA

EPG5

976

Q9HCE0
CRLNTQPGKKVFYPV

CSGALNACT1

371

Q8TDX6
ILNKPGLKYKPVCNQ

AKR1C3

176

P42330
YPKSLQAQPVTGVKQ

ADGRA3

216

Q8IWK6
INPIIYPCSSQEFKK

ADRA1A

321

P35348
LCAQDNPMNPKKYLG

ACMSD

246

Q8TDX5
KCPNLTYLNLSGNKI

ANP32E

86

Q9BTT0
TYGIASVPNQPLKKQ

DDX20

461

Q9UHI6
RYKQVKVGNCNTPKP

ACBD6

71

Q9BR61
KNLKSYFQPSPSCPQ

APEX2

391

Q9UBZ4
KPYQPKVCENAVHGQ

CDH5

481

P33151
VPYQSPQGILSKCLQ

ANKRD33

371

Q7Z3H0
PQVPLCVSYKGEKNS

KIAA0100

2121

Q14667
PPQVLRVKLCGNVKY

MCUB

31

Q9NWR8
PEVTNYSLKGCQGKP

KIT

141

P10721
TKNLEKCNQPTPVRY

LIPM

326

Q5VYY2
LCANSPRNYAKLPAK

MFI

96

Q8NCR3
CNLQKFPKPLPQEYQ

LMLN

441

Q96KR4
KKPAQAPIQACLNFP

FAM90A22

291

A8MWA6
LSPEICQNKPYNNKT

NEK5

171

Q6P3R8
LEQKQKQVCAGQYGP

EVPL

156

Q92817
AQNVKQFGTPKPCQY

FAM76B

61

Q5HYJ3
TYTPENLLNKCKPGD

LRATD2

106

Q96KN1
NPLPIYCALNTKGQS

PLA2G4B

431

P0C869
CNLILGNPPSKVYGN

PNO1

226

Q9NRX1
SCKPPQYGQLETKHI

MON2

1371

Q7Z3U7
KKYPTCNSPKQSPIN

PTPRZ1

51

P23471
PLLVNCYKIPQLENK

GREB1L

421

Q9C091
LGRDPKYICQKPSIQ

HUWE1

691

Q7Z6Z7
VCQQPVYIPKKAASK

NUTM1

326

Q86Y26
APTNFPLKCQKQRGA

FAM157B

331

P0CG42
PNNLAVPLYKNGVKI

CPS1

1061

P31327
IKQKCPLYEANGQAV

KDM1A

356

O60341
NSPGQYIQCFTVKPK

DOCK1

1396

Q14185
YIPNNKGQLIKACKT

CYTH2

326

Q99418
PKGLPVKQYAVQSQL

MTFMT

91

Q96DP5
LKQELPKYLPALQGC

CDK11A

406

Q9UQ88
DCNPNFIINGPKKIQ

CFHR5

236

Q9BXR6
CHKCPQLQYTGVQKP

LTBP3

316

Q9NS15
QCELCPLPGTAQYKK

FBN2

2421

P35556
NPKCKSKINYGGDIP

SEC14L2

251

O76054
NPKCLTKINYGGEIP

SEC14L3

251

Q9UDX4
NPKCLTKINYGGEVP

SEC14L4

251

Q9UDX3
NPKCLTKINYGGEVP

SEC14L6

251

B5MCN3
GQAENQPYQPKGKCL

SCAPER

1356

Q9BY12
EKSLPCKVSNNNYPI

PMS1

521

P54277
LLPQKSLSPQQYQKG

IFNE

61

Q86WN2
YPNSLCIKVNGKLFP

PIAS2

226

O75928
KPKPQVYSTLLNSGC

OAS3

161

Q9Y6K5
NVCFSPANKPKILAN

RTTN

2126

Q86VV8
NPPKKANGIITQYCL

USH2A

2076

O75445
SCQGKNYNLKVTLPG

SMCHD1

896

A6NHR9
SPYAKTLQPTKQPNC

PLD5

496

Q8N7P1
IRLQAQNNPLPKGKC

SLC25A40

41

Q8TBP6
QNNPLPKGKCFVYSN

SLC25A40

46

Q8TBP6
KTPPIAVQKISQYAC

DNTT

141

P04053
KALVASLPGQLQYKC

ABCC6

1381

O95255
AYNQGLKKCPHSTPL

PRPF6

731

O94906
TPLCAILKQKAPQQY

POT1

346

Q9NUX5
KQVYQIVKPLNPNFC

NANS

166

Q9NR45
SEYKEKCFLPQNINP

SH3TC2

36

Q8TF17
STKGCNVNKLNYPPF

SI

516

P14410
IIKSNYQGLPLPCVK

SRPK1

176

Q96SB4
YQGLPLPCVKKIIQQ

SRPK1

181

Q96SB4
KKCAQNVQLYGTPKP

FAM76A

56

Q8TAV0
IKSNYQGLPVPCVKS

SRPK3

176

Q9UPE1
LNCKAQQKYSPVGNL

ABRA

231

Q8N0Z2
GDSPIQKHKQLYPSC

BIRC2

96

Q13490
ILNKPGLKYKPVCNQ

AKR1C1

176

Q04828
ILNKPGLKYKPVCNQ

AKR1C2

176

P52895
KKILGENAKPNYGCQ

ASCC3

311

Q8N3C0
PLLLKVCNNPGLYSN

NCAPD2

1016

Q15021
PYLKSKNNCQNQPPS

CKAP2L

36

Q8IYA6
YLKIQPGAVPGCNNS

PLPPR4

501

Q7Z2D5
KCPGNYTNPLKVQTV

TMEM192

81

Q8IY95
QSKEVPENPNYALKC

WDR5B

21

Q86VZ2
ESLQLKPGQVVYKCP

ZDHHC3

116

Q9NYG2
GYPLCQKKLGIVPKQ

RPAP2

101

Q8IXW5
VCKIPPGCNLKIFNN

SMAD3

331

P84022
YCNPKKIQGLELQQI

PXK

251

Q7Z7A4
TGNPRCQKPYFLKEI

SLIT2

686

O94813
KLLTCNGVYLNPAPG

USP9Y

2016

O00507
LEKGCSFLPDPYQKQ

PSAP

436

P07602
YVLKPQQMCKGTFNP

PLCH1

706

Q4KWH8
KCLQIQTLLYGPQDK

TTC23

381

Q5W5X9
CGTPNYLSPEVLNKQ

PLK2

241

Q9NYY3
NRKVQLTYLPHGCPK

PPIP5K2

476

O43314
KGPLPKSYAIICNNF

TEX15

1026

Q9BXT5
KPCPNNVEKSNRIYQ

TINAG

336

Q9UJW2
NKPVNLYCKASPATQ

UNC5C

76

O95185
VCKQPQVYGNDIKPG

TMPRSS11A

336

Q6ZMR5
QTKNPNYIRCIKPND

MYO1B

586

O43795
ACAKAPYTQKQVTPL

MYO7B

1376

Q6PIF6