Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	Fanconi anaemia nuclear complex	FANCF FANCG FANCI	6.16e-05	15	110	3	GO:0043240
GeneOntologyCellularComponent	Gtr1-Gtr2 GTPase complex	RRAGC RRAGD	1.64e-04	4	110	2	GO:1990131
MousePheno	double outlet right ventricle, Taussig bing type	MATR3 PSME4 SLIT3	1.42e-05	9	79	3	MP:0011668
Domain	Leu-rich_rpt	LRRN1 NLRX1 CNTRL FBXL17 IGSF10 LRR1 LRRC20 SLIT3 RXFP1 SCRIB LRRC28 LRRC36	6.80e-08	271	110	12	IPR001611
Domain	-	LRRN1 NLRX1 CNTRL FBXL17 IGSF10 LRR1 LRRC20 SLIT3 RXFP1 SCRIB LRRC28 LRRC36	4.23e-07	321	110	12	3.80.10.10
Domain	L_dom-like	LRRN1 NLRX1 CNTRL FBXL17 IGSF10 LRR1 LRRC20 SLIT3 RXFP1 SCRIB LRRC28 LRRC36	5.31e-07	328	110	12	IPR032675
Domain	Leu-rich_rpt_typical-subtyp	LRRN1 CNTRL IGSF10 LRR1 LRRC20 SLIT3 RXFP1 SCRIB LRRC28	1.03e-06	177	110	9	IPR003591
Domain	LRR_TYP	LRRN1 CNTRL IGSF10 LRR1 LRRC20 SLIT3 RXFP1 SCRIB LRRC28	1.03e-06	177	110	9	SM00369
Domain	LRR_1	LRRN1 CNTRL LRR1 LRRC20 SLIT3 RXFP1 SCRIB LRRC28 LRRC36	5.92e-06	219	110	9	PF00560
Domain	LRR_8	LRRN1 IGSF10 LRRC20 SLIT3 RXFP1 SCRIB LRRC28	6.88e-05	171	110	7	PF13855
Domain	-	GTPBP4 SPAST EP400 ABCA12 HS3ST5 RRAGC DHX30 DNAH1 RRAGD HELZ2 ATL2 DDX41 DNAH6 GNL1	1.23e-04	746	110	14	3.40.50.300
Domain	P-loop_NTPase	GTPBP4 SPAST EP400 ABCA12 HS3ST5 RRAGC DHX30 DNAH1 RRAGD IQCB1 HELZ2 ATL2 DDX41 DNAH6 GNL1	1.33e-04	848	110	15	IPR027417
Domain	LRR	LRRN1 CNTRL LRR1 SLIT3 RXFP1 SCRIB LRRC36	1.88e-04	201	110	7	PS51450
Domain	Gtr1_RagA	RRAGC RRAGD	2.05e-04	4	110	2	PF04670
Domain	Gtr1_RagA	RRAGC RRAGD	2.05e-04	4	110	2	IPR006762
Domain	ARM-type_fold	USP34 ARMC3 NOC2L ECPAS RANBP17 PSME4 IQCB1 PRKDC	8.92e-04	339	110	8	IPR016024
Domain	ZnF_UBP	HDAC6 USP39	1.83e-03	11	110	2	SM00290
Domain	LRRNT	LRRN1 IGSF10 SLIT3 RXFP1	2.69e-03	98	110	4	IPR000372
Domain	LRRNT	LRRN1 IGSF10 SLIT3 RXFP1	2.69e-03	98	110	4	SM00013
Domain	Dynein_heavy_chain_D4_dom	DNAH1 DNAH6	2.99e-03	14	110	2	IPR024317
Domain	Dynein_HC_stalk	DNAH1 DNAH6	2.99e-03	14	110	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH1 DNAH6	2.99e-03	14	110	2	IPR013602
Domain	NPIP	NPIPB15 NPIPB9	2.99e-03	14	110	2	IPR009443
Domain	Znf_UBP	HDAC6 USP39	2.99e-03	14	110	2	IPR001607
Domain	DHC_N2	DNAH1 DNAH6	2.99e-03	14	110	2	PF08393
Domain	MT	DNAH1 DNAH6	2.99e-03	14	110	2	PF12777
Domain	AAA_8	DNAH1 DNAH6	2.99e-03	14	110	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH1 DNAH6	2.99e-03	14	110	2	IPR011704
Domain	zf-UBP	HDAC6 USP39	2.99e-03	14	110	2	PF02148
Domain	ZF_UBP	HDAC6 USP39	2.99e-03	14	110	2	PS50271
Domain	AAA_5	DNAH1 DNAH6	2.99e-03	14	110	2	PF07728
Domain	DHC_fam	DNAH1 DNAH6	3.43e-03	15	110	2	IPR026983
Domain	Dynein_heavy_dom	DNAH1 DNAH6	3.43e-03	15	110	2	IPR004273
Domain	Dynein_heavy	DNAH1 DNAH6	3.43e-03	15	110	2	PF03028
Domain	LRR_6	NLRX1 FBXL17 LRR1	4.17e-03	55	110	3	PF13516
Domain	ARM-like	ARMC3 ECPAS RANBP17 PSME4 IQCB1 PRKDC	5.29e-03	270	110	6	IPR011989
Domain	GTP_binding_domain	GTPBP4 GNL1	5.51e-03	19	110	2	IPR006073
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GTPBP4 HDAC6 EP400 NOC2L MATR3 PSMB4 OAS3 DHX30 RIN1 METTL13 PSME4 SUGP2 FANCI MCM3AP BOP1 PRKDC SCRIB TP53RK DDX41	7.47e-08	1353	113	19	29467282
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 SPAST EP400 MATR3 ECPAS ARHGEF10L TUBGCP6 PSME4 USP38 SLIT3 BOP1 MED23	1.66e-07	529	113	12	14621295
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	GTPBP4 KRT78 MATR3 ERFE HMCN2 RXFP1 PRKDC USP39 TP53RK DNAH6	3.09e-07	361	113	10	26167880
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	GTPBP4 USP34 KAT5 EP400 MATR3 MED8 PSMB4 ECPAS SUGP2 FANCI BOP1 PRKDC USP39 MED23 DDX41	1.07e-06	1014	113	15	32416067
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	GTPBP4 NOC2L MATR3 DHX30 PRKDC HSPA14	1.86e-06	112	113	6	28416769
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	KAT5 EP400 MATR3 ECPAS FANCI PRKDC	2.78e-06	120	113	6	27320910
Pubmed	The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.	FANCF FANCG FANCI	5.41e-06	11	113	3	19965384
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GCFC2 HDAC6 EP400 MATR3 ECPAS TUBGCP6 SUGP2 HELZ2 TIMELESS PRKDC SCRIB DDX41	8.61e-06	774	113	12	15302935
Pubmed	Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.	FANCF FANCG FANCI	9.33e-06	13	113	3	27986371
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GTPBP4 USP34 NOC2L ECPAS DHX30 SUGP2 FANCI MCM3AP HELZ2 BOP1 PRKDC	9.68e-06	653	113	11	22586326
Pubmed	Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling.	KAT5 EP400	1.05e-05	2	113	2	24287617
Pubmed	An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.	KAT5 EP400	1.05e-05	2	113	2	18614019
Pubmed	The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.	KAT5 EP400	1.05e-05	2	113	2	19169279
Pubmed	TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer.	KAT5 EP400	1.05e-05	2	113	2	33099470
Pubmed	DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly.	HDAC6 PRKDC	1.05e-05	2	113	2	33404279
Pubmed	Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis.	ECPAS PSME4	1.05e-05	2	113	2	37189334
Pubmed	The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.	FANCF FANCG FANCI	1.48e-05	15	113	3	19536649
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GTPBP4 USP34 KAT5 HDAC6 EP400 ABCA12 OAS3 TUBGCP6 METTL13 HMCN2 SUGP2 MCM3AP SCRIB DDX41	1.62e-05	1116	113	14	31753913
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	HDAC6 MATR3 PSMB4 OAS3 DHX30 SUGP2 HELZ2 BOP1 DDX41	2.36e-05	469	113	9	37314180
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	GTPBP4 KRT78 NOC2L MATR3 DHX30 SUGP2 BOP1 PRKDC USP39 DDX41	2.94e-05	605	113	10	28977666
Pubmed	Loss of heterozygosity in FANCG, FANCF and BRIP1 from head and neck squamous cell carcinoma of the oral cavity.	FANCF FANCG	3.13e-05	3	113	2	28440438
Pubmed	GANP regulates the choice of DNA repair pathway by DNA-PKcs interaction in AID-dependent IgV region diversification.	MCM3AP PRKDC	3.13e-05	3	113	2	24808370
Pubmed	The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.	KAT5 PRKDC	3.13e-05	3	113	2	16603769
Pubmed	The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.	RRAGC RRAGD	3.13e-05	3	113	2	24095279
Pubmed	Analysis of Myc-induced histone modifications on target chromatin.	KAT5 EP400	3.13e-05	3	113	2	18985155
Pubmed	The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.	KAT5 EP400	3.13e-05	3	113	2	23266955
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	GTPBP4 KRT78 KAT5 HDAC6 EP400 MATR3 DHX30 SUGP2 HELZ2 PRKDC USP39 MED23 DDX41	5.16e-05	1082	113	13	38697112
Pubmed	Fanconi Anemia	FANCF FANCG FANCI	5.64e-05	23	113	3	20301575
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GTPBP4 KRT78 DSG3 NOC2L MATR3 OAS3 DHX30 HELZ2 BOP1 PRKDC USP39 SCRIB DDX41 HSPA14	5.91e-05	1257	113	14	36526897
Pubmed	TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.	KAT5 PRKDC	6.25e-05	4	113	2	32832608
Pubmed	The SH3 domain of alphaII spectrin is a target for the Fanconi anemia protein, FANCG.	FANCF FANCG	6.25e-05	4	113	2	19102630
Pubmed	Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells.	FANCF FANCG	6.25e-05	4	113	2	11750104
Pubmed	Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants.	FANCF FANCG	6.25e-05	4	113	2	12444097
Pubmed	The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.	FANCF FANCG	6.25e-05	4	113	2	11063725
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 EP400 NLRX1 TMC6 ARHGEF10L DHX30 PSME4 SUGP2 FANCI MCM3AP HELZ2 PRKDC PPP1R16A	6.38e-05	1105	113	13	35748872
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	USP34 RRAGC PSME4 SUGP2 FANCI IQCB1	7.02e-05	212	113	6	33853758
Pubmed	Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy Overview	IQCB1 AIPL1 DTHD1	7.29e-05	25	113	3	30285347
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	KAT5 EP400 MED8 MED23	7.76e-05	69	113	4	28481362
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	TMCO5A CNTRL ANO5 C2orf78 CC2D2B IGSF10 SUGP2 SYCP1 RXFP1 VPS13B	8.37e-05	686	113	10	29987050
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	USP34 MATR3 ECPAS SUGP2 PRKDC MED23	8.61e-05	220	113	6	35785414
Pubmed	Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.	KAT5 EP400 PSMB4	9.23e-05	27	113	3	21320693
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	HDAC6 MATR3 DHX30 TUBGCP6 SYCP1 TIMELESS PRKDC USP39 SCRIB ATL2 DDX41 GNL1 VPS13B	9.94e-05	1155	113	13	20360068
Pubmed	The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression.	KAT5 EP400	1.04e-04	5	113	2	20351180
Pubmed	The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.	FANCF FANCG	1.04e-04	5	113	2	16474167
Pubmed	Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.	KAT5 EP400	1.04e-04	5	113	2	16601686
Pubmed	Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.	DNAH1 DNAH6	1.04e-04	5	113	2	39056782
Pubmed	Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway.	FANCF FANCG	1.04e-04	5	113	2	11157805
Pubmed	The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC.	FANCF FANCG	1.04e-04	5	113	2	12239156
Pubmed	The Fanconi anemia gene product FANCF is a flexible adaptor protein.	FANCF FANCG	1.04e-04	5	113	2	15262960
Pubmed	SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.	RRAGC RRAGD	1.04e-04	5	113	2	22575674
Pubmed	Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.	FANCF FANCG	1.04e-04	5	113	2	17082180
Pubmed	Evidence for at least eight Fanconi anemia genes.	FANCF FANCG	1.04e-04	5	113	2	9382107
Pubmed	A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.	RRAGC RRAGD	1.04e-04	5	113	2	32612235
Pubmed	Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2.	FANCF FANCG	1.04e-04	5	113	2	16621732
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	KAT5 HDAC6 EP400 NOC2L PSMB4 RUNX1T1 ECPAS METTL13 SUGP2 SCRIB HSPA14	1.13e-04	857	113	11	25609649
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	GTPBP4 MATR3 TEX15 DHX30 SYCP1 VPS13B	1.21e-04	234	113	6	36243803
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GTPBP4 KRT78 EP400 NOC2L MATR3 DHX30 SUGP2 BOP1 PRKDC USP39 SCRIB DDX41	1.29e-04	1024	113	12	24711643
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	GTPBP4 EMC7 EP400 MATR3 OAS3 METTL13 RRAGD SUGP2 MCM3AP HELZ2 BOP1 DDX41 GNL1 HSPA14	1.47e-04	1371	113	14	36244648
Pubmed	A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.	RRAGC RRAGD	1.56e-04	6	113	2	14660641
Pubmed	FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.	FANCF FANCG	1.56e-04	6	113	2	18212739
Pubmed	Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress.	KAT5 HDAC6	1.56e-04	6	113	2	31857589
Pubmed	Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.	KAT5 PLIN2	1.56e-04	6	113	2	34077757
Pubmed	Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance.	FANCF FANCG	1.56e-04	6	113	2	20450923
Pubmed	Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.	RRAGC RRAGD	1.56e-04	6	113	2	11073942
Pubmed	FANCE: the link between Fanconi anaemia complex assembly and activity.	FANCF FANCG	1.56e-04	6	113	2	12093742
Pubmed	Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.	RRAGC RRAGD	1.56e-04	6	113	2	24529380
Pubmed	Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.	RRAGC RRAGD	1.56e-04	6	113	2	24081491
Pubmed	Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems.	FANCF FANCG	1.56e-04	6	113	2	12649160
Pubmed	The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.	RRAGC RRAGD	1.56e-04	6	113	2	18497260
Pubmed	Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.	KAT5 EP400	1.56e-04	6	113	2	20070254
Pubmed	Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer.	KAT5 EP400	1.56e-04	6	113	2	29437725
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	GTPBP4 NOC2L MATR3 DHX30 SUGP2 IQCB1 BOP1 PRKDC MED23 HSPA14	1.90e-04	759	113	10	35915203
Pubmed	Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.	RRAGC RRAGD	2.17e-04	7	113	2	25259925
Pubmed	The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).	ANO5 FANCF	2.17e-04	7	113	2	15124103
Pubmed	Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.	SPAST ATL2	2.17e-04	7	113	2	23969831
Pubmed	Evidence for subcomplexes in the Fanconi anemia pathway.	FANCF FANCG	2.17e-04	7	113	2	16720839
Pubmed	The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments.	FANCF FANCG	2.17e-04	7	113	2	15082718
Pubmed	The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.	FANCG FANCI	2.17e-04	7	113	2	24451376
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	HDAC6 NOC2L SLC7A14 IGSF10 ADAMTS15	2.28e-04	168	113	5	30631154
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	GTPBP4 ECPAS DHX30 SUGP2 FANCI PRKDC USP39 SCRIB DDX41	2.44e-04	638	113	9	33239621
Pubmed	DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.	GTPBP4 NOC2L BOP1	2.80e-04	39	113	3	25825154
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	GTPBP4 MATR3 DHX30 SUGP2 SCRIB DDX41	2.83e-04	274	113	6	34244482
Pubmed	DNA polymerase POLN participates in cross-link repair and homologous recombination.	FANCG FANCI	2.89e-04	8	113	2	19995904
Pubmed	ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.	HDAC6 RUNX1T1	2.89e-04	8	113	2	11533236
Pubmed	Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.	RRAGC RRAGD	2.89e-04	8	113	2	26582740
Pubmed	Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response.	KAT5 EP400	2.89e-04	8	113	2	17704809
Pubmed	X-linked inheritance of Fanconi anemia complementation group B.	FANCF FANCG	2.89e-04	8	113	2	15502827
Pubmed	Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.	PRKDC MED23	2.89e-04	8	113	2	10823961
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	GTPBP4 GCFC2 MATR3 ECPAS DHX30 PRKDC SCRIB DDX41 GNL1	2.90e-04	653	113	9	33742100
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	USP34 MATR3 SUGP2 MCM3AP AIPL1	3.14e-04	180	113	5	35198878
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	GTPBP4 MATR3 DHX30 PRKDC MED23	3.30e-04	182	113	5	32239614
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HDAC6 TUBGCP6 PSME4 GNL1 HSPA14	3.39e-04	183	113	5	31932471
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	GCFC2 RRAGC RANBP17 RRAGD USP38	3.65e-04	186	113	5	33637726
Pubmed	FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.	FANCF FANCG	3.71e-04	9	113	2	17396147
Pubmed	The p400 complex is an essential E1A transformation target.	KAT5 EP400	3.71e-04	9	113	2	11509179
Pubmed	Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1.	FANCF FANCG	3.71e-04	9	113	2	23303816
Pubmed	Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.	RRAGC RRAGD	3.71e-04	9	113	2	24337580
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	NOC2L MATR3 USP39 MED23	3.78e-04	104	113	4	26167872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 DHX30 SUGP2 MCM3AP BRINP2 SCRIB VPS13B	3.81e-04	407	113	7	12693553
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	GTPBP4 NOC2L MATR3 DHX30 SUGP2 FANCI BOP1 PRKDC USP39 ATL2 DDX41	3.87e-04	989	113	11	36424410
Interaction	GPR182 interactions	EMC7 NLRX1 TMC6 ECPAS FAAH FANCG METTL13 FANCI TIMELESS PRKDC MED23 ATL2	7.94e-06	455	111	12	int:GPR182
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCF FANCG FANCI	5.54e-05	20	68	3	548
GeneFamily	Ubiquitin specific peptidases	USP34 USP38 USP39	1.22e-03	56	68	3	366
GeneFamily	Dyneins, axonemal	DNAH1 DNAH6	1.83e-03	17	68	2	536
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	GPATCH3 SUGP2	3.07e-03	22	68	2	579
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP34 SPAST USP38 ZNF253 PRKDC MED23 VPS13B	5.94e-07	193	112	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAAH FANCF FANCG KLHDC1 SEC22C FANCI	3.11e-06	159	112	6	f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	ARMC3 TTC21A ANO5 ERFE EPS8L3 DNAH6	4.58e-06	170	112	6	d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPIPB9 TTC21A NR6A1 ADAMTS15 SCRIB DNAH6	4.73e-06	171	112	6	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	Control_saline-Epithelial_airway\|Control_saline / Treatment groups by lineage, cell group, cell type	KRT78 ARMC3 TTC21A DNAH1 DTHD1 DNAH6	1.09e-05	198	112	6	e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCell	Control_saline-Epithelial_airway-airway_epithelial\|Control_saline / Treatment groups by lineage, cell group, cell type	KRT78 ARMC3 TTC21A DNAH1 DTHD1 DNAH6	1.09e-05	198	112	6	e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	OAS3 ARHGEF10L DNAH1 RRAGD FANCI TIMELESS	1.13e-05	199	112	6	c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT78 ABCA12 ANO5 TEX15 BRINP2	2.89e-05	141	112	5	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT78 ABCA12 ANO5 TEX15 BRINP2	2.89e-05	141	112	5	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
Disease	autosomal recessive limb-girdle muscular dystrophy type 2L (is_implicated_in)	ANO5 FKTN	1.33e-05	2	108	2	DOID:0110284 (is_implicated_in)
Disease	Fanconi anemia	FANCF FANCG FANCI	1.69e-05	14	108	3	cv:C0015625
Disease	Bone marrow hypocellularity	FANCF FANCG FANCI	3.74e-05	18	108	3	C1855710
Disease	Fanconi Anemia	FANCF FANCG FANCI	1.03e-04	25	108	3	C0015625
Disease	Pancytopenia	FANCF FANCG FANCI	1.17e-04	26	108	3	C0030312
Disease	Acute monocytic leukemia	FANCF FANCG FANCI	1.17e-04	26	108	3	C0023465
Disease	follicular lymphoma (implicated_via_orthology)	RRAGC RRAGD	1.32e-04	5	108	2	DOID:0050873 (implicated_via_orthology)
Disease	Miller Dieker syndrome	FANCF FANCG FANCI	1.63e-04	29	108	3	C0265219
Disease	Leber congenital amaurosis (is_implicated_in)	IQCB1 AIPL1	1.97e-04	6	108	2	DOID:14791 (is_implicated_in)
Disease	Abnormality of radial ray	FANCF FANCG FANCI	2.40e-04	33	108	3	C4228778
Disease	tongue squamous cell carcinoma (is_marker_for)	FANCF FANCG FANCI	3.38e-04	37	108	3	DOID:0050865 (is_marker_for)
Disease	nephronophthisis (implicated_via_orthology)	TTC21A CNTRL	4.70e-04	9	108	2	DOID:12712 (implicated_via_orthology)
Disease	Malignant Head and Neck Neoplasm	FANCF FANCG FANCI	5.66e-04	44	108	3	C0278996
Disease	Fanconi anemia (is_implicated_in)	FANCG FANCI	5.86e-04	10	108	2	DOID:13636 (is_implicated_in)
Disease	Congenital ichthyosis of skin	ABCA12 LIPN	7.14e-04	11	108	2	cv:C0020758
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	ABCA12 LIPN	7.14e-04	11	108	2	C0079154
Disease	Mouth Diseases	FANCG HSPA14	8.55e-04	12	108	2	C0026636
Disease	Autosomal recessive limb-girdle muscular dystrophy	ANO5 FKTN	1.17e-03	14	108	2	cv:C2931907
Disease	MYELODYSPLASTIC SYNDROME	FANCF FANCG FANCI	1.93e-03	67	108	3	C3463824
Disease	age at onset, Parkinson disease	DSG3 KLHDC1	1.95e-03	18	108	2	EFO_0004847, MONDO_0005180
Disease	TNF-related apoptosis-inducing ligand measurement	DSG3 AIPL1 NCEH1	2.37e-03	72	108	3	EFO_0008300
Disease	Leber Congenital Amaurosis	IQCB1 AIPL1	2.92e-03	22	108	2	C0339527
Disease	amino acid measurement	GCFC2 LRRN1 ABCA12 RUNX1T1 GRHL1 SLIT3 BRINP2 PRKDC	3.51e-03	678	108	8	EFO_0005134

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRFINPDLLVNVLPK	TMCO5A	246	Q8N6Q1
NDLLQNPLLVPVKVL	BOP1	696	Q14137
LLQPDLQVPKFVDLT	C2orf16	196	Q68DN1
KQLLELPLNLTIVSP	EP400	2381	Q96L91
VKPIQRFPQFILLLQ	ARHGEF10L	456	Q9HCE6
PLQDLISLILVENPV	CNTRL	216	Q7Z7A1
QKEPQPLVFVIELLQ	AIPL1	141	Q9NZN9
PLAPLLALINNIVEI	ANO5	691	Q75V66
VKLIPLPFLTLDQPQ	C2orf78	716	A6NCI8
PLLLQKILENTVPDA	ARHGEF37	176	A1IGU5
IVILIIILKFGNILP	ABCA12	1126	Q86UK0
LFQNIRPLFINKPLI	GTPBP4	271	Q9BZE4
KLQELNAIPPILDLL	ARMC3	186	Q5W041
QLKILRFLVPLEQSP	APEX2	336	Q9UBZ4
QFPLPKNLLAKVIQI	DHX30	241	Q7L2E3
IKALNPPQQLLDIFL	CC2D2B	1121	Q6DHV5
PSILNPINIVVVKVL	ADAMTS15	256	Q8TE58
QPKLAPFVIQALIQV	RANBP17	96	Q9H2T7
ILLLFLLPSVPIESQ	NTF4	11	P34130
AQPLLREVLEKQPVL	PSMB4	191	P28070
LILTVKILDINDNPP	DSG3	141	P32926
LPLQTVQRLLKAVQP	FANCI	491	Q9NVI1
LPGLFLLQQLPDQVK	KIAA0100	266	Q14667
LVTPQDVARILPQIK	LIPN	346	Q5VXI9
FLKVIAVALLQPPLS	FANCF	201	Q9NPI8
DKITPENLPQILLQL	MATR3	131	P43243
VIPFLKANLPLLQRE	RUNX1T1	181	Q06455
VLPVIKLQAPLTLLE	LRR1	311	Q96L50
QKLVQLSVLVPPAFR	HMCN2	3026	Q8NDA2
LLQAKPFQPALPLVV	MCM3AP	1486	O60318
LPIPVQITLRFNLPK	KAT5	106	Q92993
TPDFALLPLNILVKV	BEND2	426	Q8NDZ0
QLQNIISKFLPPVLL	ECPAS	31	Q5VYK3
LPPRIITQLQLQFPK	GPATCH3	211	Q96I76
EPLPELQLVEKFLNL	HS3ST5	261	Q8IZT8
LQLVEKFLNLPPRIS	HS3ST5	266	Q8IZT8
QEVTPLLLELQKLPE	ISM2	181	Q6H9L7
LPFLKELDLRLNPVV	LRRC36	96	Q1X8D7
PLIADQAVLQLLPKT	NCEH1	326	Q6PIU2
IIPPEALLKEFQLLL	ERFE	126	Q4G0M1
QVISPLLTPKAINLL	EPS8L3	336	Q8TE67
LLNVVLKSQPLVPRE	MED23	1126	Q9ULK4
NLLTPLKIEIDPQFQ	KRT78	91	Q8N1N4
PLLEVALQTINLDLP	TUBGCP6	916	Q96RT7
VLVLNKVDLAPPALV	GNL1	221	P36915
SKAPQFLIEVELLLP	FANCG	316	O15287
LNAEVRVIAPPLIKF	LRRC20	156	Q8TCA0
TPSPQKLDNLIIIII	NPIPB7	51	O75200
LRALPLLFNLIKVVP	NLRX1	546	Q86UT6
LLLEAKQKVPPVLQV	DDX41	551	Q9UJV9
FSPLPLKVIRPILQQ	HIPK3	291	Q9H422
IGFPELVLPVVLQLK	NOC2L	541	Q9Y3T9
TPSPQKLDNLIIIII	NPIPB15	51	A6NHN6
IELLPQTFQILPKVP	GPR45	336	Q9Y5Y3
QALPLNIIAPKAVLV	MAS1L	71	P35410
PLLLKEQTIQVPGLN	F2R	236	P25116
KKIPLIPVFLNVLHN	OR56B4	271	Q8NH76
VTQNILLKVPEPINL	DNAH1	3991	Q9P2D7
LDPALEPILLKQIFI	DNAH6	3131	Q9C0G6
QFKVQEIGQLVPLLP	FAM124B	206	Q9H5Z6
LLVKIQVIAAPPVIL	IGSF10	1831	Q6WRI0
RVQVLKNVPFNIVLP	GRHL1	111	Q9NZI5
VLVIALPIPIIVNNF	KCNB2	406	Q92953
ISFPPVNLEIIKKQL	GCFC2	261	P16383
INQLPPSILLKIFSN	FBXL17	321	Q9UF56
PLLLVLVANPILFQK	GPR143	201	P51810
NLVPLLLAPENLVEK	ATL2	326	Q8NHH9
PQRQELLVKLLDVPT	C17orf80	211	Q9BSJ5
VLVQLKIQPVDPALV	DTHD1	336	Q6ZMT9
PVFLIDPLILELINK	FKTN	71	O75072
PEQNVPVILLKLKEI	IQCB1	21	Q15051
QISLLPPKLLQQVLK	KLHDC1	361	Q8N7A1
AVFLVPILLLLQVKP	LLCFC1	11	Q96L11
LPLLIFVLLPKVVNT	EMC7	171	Q9NPA0
SEALLALPLPQLVQK	FAAH	71	O00519
VLLPVALEFQPQLVL	HDAC6	326	Q9UBN7
NPELLLEIPLALLVV	METTL13	486	Q8N6R0
LIPLVQFPQAEKVVL	HELZ2	2371	Q9BYK8
IQEELKLQPPAVLTL	SEC22C	141	Q9BRL7
KLIPQLPTLENLLNI	RRAGD	236	Q9NQL2
TPSPQKLDNLIIIII	NPIPB9	66	F8W1W9
LVKVPQLALQKVPNL	LRRN1	251	Q6UXK5
IPKLQQLIKDLFPAV	HSPA14	341	Q0VDF9
EKTPLFRNQVIIPLV	MED8	66	Q96G25
FLKQQLQKPRPIILD	OAS3	1026	Q9Y6K5
NVPLEQLPLLFKVVL	NR6A1	456	Q15406
LPSPVELEQVRQKLL	RIN1	486	Q13671
LIPQLPTLENLLNIF	RRAGC	236	Q9HB90
EQLIIPQVPLFNILA	USP39	406	Q53GS9
LPENLAQKLPNLVEL	LRRC28	56	Q86X40
AKVIVIPNPVDLRLN	PKDREJ	1161	Q9NTG1
QGLLKQVLFPPSVVL	PPP1R16A	61	Q96I34
ISKLPQPEAVVALLQ	SCRIB	616	Q14160
KQALQEIVILPSLRP	SPAST	351	Q9UBP0
PENKVQLLGLQVLLP	BRINP2	251	Q9C0B6
FNLLVILISEPQIPK	C12orf56	441	Q8IXR9
LVFVILQQPENPKKL	SLC7A14	611	Q8TBB6
LQVLPELLFQSTPKL	SLIT3	121	O75094
EEIQLLKQILSAPLP	TIMELESS	641	Q9UNS1
PALQKVNFLPVLEQV	SYCP1	66	Q15431
IQLKPFLLSVPQVTV	PPM1M	351	Q96MI6
IQFPIQKIPLGLDLK	SUGP2	291	Q8IX01
VIFILPINSALNPIL	RXFP1	666	Q9HBX9
SPLLKQVAVILNPVV	TTC21A	481	Q8NDW8
QLQLLPLFFKIAPVE	PSME4	1596	Q14997
LDNVSLPLVLELPVK	USP38	781	Q8NB14
PIVPLNIRLFLAKLV	PRKDC	2136	P78527
AVILKTFLRELPQPL	ARHGAP8	296	P85298
IVKNVTDLLNVPPLL	ZNF253	481	O75346
NPVKLRKLVIQPVNL	VPS13B	3581	Q7Z7G8
LPIIQKLEPQIAVAN	PLIN2	66	Q99541
KPPLEQLNIVLIDFG	TP53RK	171	Q96S44
PLLPAVQIIKLLLVF	TMC6	611	Q7Z403
INRIDPLAPLQLLIF	ERVK-19	331	Q9WJR5
KQLNPALIPTLQELL	USP34	3306	Q70CQ2
SPILLPDLQIKITNI	TEX15	766	Q9BXT5
QTQLIPVQKALDLPF	ZP4	396	Q12836