Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionN6-methyladenosine-containing RNA reader activity

YTHDF1 YTHDF3

9.93e-0515202GO:1990247
GeneOntologyMolecularFunctionprotein-RNA adaptor activity

YTHDF1 YTHDF3

2.60e-0424202GO:0140517
GeneOntologyMolecularFunctionribosome binding

YTHDF1 YTHDF3

6.34e-03120202GO:0043022
GeneOntologyBiologicalProcessstress granule assembly

YTHDF1 UBAP2L YTHDF3

5.45e-0636203GO:0034063
GeneOntologyCellularComponentcytoplasmic stress granule

YTHDF1 UBAP2L YTHDF3

1.01e-0496203GO:0010494
DomainYTH

YTHDF1 YTHDF3

9.79e-065192PS50882
DomainYTH_domain

YTHDF1 YTHDF3

9.79e-065192IPR007275
DomainYTH

YTHDF1 YTHDF3

9.79e-065192PF04146
DomainTPR

KLC1 ASPH

7.50e-03129192SM00028
DomainTPR_repeat

KLC1 ASPH

7.95e-03133192IPR019734
DomainTPR-contain_dom

KLC1 ASPH

1.00e-02150192IPR013026
DomainTPR

KLC1 ASPH

1.20e-02165192PS50005
DomainTPR_REGION

KLC1 ASPH

1.20e-02165192PS50293
Domain-

KLC1 ASPH

1.85e-022071921.25.40.10
Pubmed

Cytoplasmic m6A reader YTHDF3 promotes mRNA translation.

YTHDF1 YTHDF3

3.14e-07220228106076
Pubmed

Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury.

YTHDF1 YTHDF3

3.14e-07220239081030
Pubmed

m6A-binding YTHDF proteins promote stress granule formation.

YTHDF1 YTHDF3

9.42e-07320232451507
Pubmed

YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.

YTHDF1 YTHDF3

9.42e-07320228106072
Pubmed

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.

YTHDF1 YTHDF3

9.42e-07320235508130
Pubmed

Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.

YTHDF1 YTHDF3

9.42e-07320234497675
Pubmed

m6A enhances the phase separation potential of mRNA.

YTHDF1 YTHDF3

9.42e-07320231292544
Pubmed

A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.

YTHDF1 YTHDF3

9.42e-07320232492408
Pubmed

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

YTHDF1 YTHDF3

9.42e-07320227371828
Pubmed

N6-methyladenosine-dependent regulation of messenger RNA stability.

YTHDF1 YTHDF3

1.88e-06420224284625
Pubmed

Context-dependent functional compensation between Ythdf m6A reader proteins.

YTHDF1 YTHDF3

3.14e-06520232943573
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TRMT1 UBAP2L PHF3 XRN2 KLC1

8.04e-0650320516964243
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

YTHDF1 UBAP2L PHF3 XRN2 RBMS2 YTHDF3

1.17e-0595420636373674
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

YTHDF1 UBAP2L RBMS2 YTHDF3

1.31e-0525820437794589
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

YTHDF1 UBAP2L RBMS2 YTHDF3

2.85e-0531520426777405
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

YTHDF1 UBAP2L YTHDF3

3.11e-0510720330995489
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

YTHDF1 UBAP2L XRN2 YTHDF3 ASPH

3.37e-0567820530209976
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

YTHDF1 UBAP2L PHF3 RBMS2 YTHDF3

4.61e-0572420536232890
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

LRCH4 YTHDF1 PHF3 YTHDF3 SCD5

4.89e-0573320534672954
Pubmed

m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.

YTHDF1 YTHDF3

5.34e-051920236039295
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

YTHDF1 UBAP2L XRN2 RBMS2 YTHDF3

7.71e-0580720522681889
Pubmed

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

YTHDF1 YTHDF3

8.61e-052420235179492
Pubmed

The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.

YTHDF1 YTHDF3

9.35e-052520235874829
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

PLCD3 UBAP2L XRN2

9.54e-0515620329961565
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

YTHDF1 PHF3 XRN2 YTHDF3 ASPH

9.68e-0584720535850772
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

YTHDF1 UBAP2L YTHDF3 ASPH

1.26e-0446220431138677
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

MAP3K21 UBAP2L XRN2 YTHDF3

1.63e-0449420426831064
Pubmed

Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells.

YTHDF1 YTHDF3

1.85e-043520237269288
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

MAP3K21 XRN2 YTHDF3 ASPH SCD5

2.17e-04100720534597346
Pubmed

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.

YTHDF1 YTHDF3 ASPH

2.77e-0422420328443643
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

YTHDF1 UBAP2L PHF3

3.11e-0423320337704626
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

LRCH4 PLCD3 XRN2 ASPH

4.62e-0465020438777146
InteractionCELF1 interactions

YTHDF1 UBAP2L XRN2 RBMS2 YTHDF3

7.49e-06288205int:CELF1
InteractionPUM2 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

1.11e-05144204int:PUM2
InteractionDAZL interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

1.14e-05145204int:DAZL
InteractionCPEB1 interactions

YTHDF1 UBAP2L XRN2 YTHDF3

1.17e-05146204int:CPEB1
InteractionZFP36 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

2.73e-05181204int:ZFP36
InteractionALG13 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

2.84e-05183204int:ALG13
InteractionAGO1 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

2.84e-05183204int:AGO1
InteractionMKRN2 interactions

SEMA6C UBAP2L XRN2 RBMS2 YTHDF3

3.03e-05385205int:MKRN2
InteractionSMAP2 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

3.23e-05189204int:SMAP2
InteractionFAM120C interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

3.36e-05191204int:FAM120C
InteractionRBM47 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

4.35e-05204204int:RBM47
InteractionRBMS1 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

4.60e-05207204int:RBMS1
InteractionLARP4 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

4.87e-05210204int:LARP4
InteractionMEX3B interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

6.05e-05222204int:MEX3B
InteractionSECISBP2 interactions

YTHDF1 UBAP2L YTHDF3

6.06e-0578203int:SECISBP2
InteractionR3HDM1 interactions

YTHDF1 UBAP2L YTHDF3

7.57e-0584203int:R3HDM1
InteractionLARP4B interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

8.18e-05240204int:LARP4B
InteractionYTHDF3 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

9.00e-05246204int:YTHDF3
InteractionHELZ interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

1.07e-04257204int:HELZ
InteractionDDX6 interactions

YTHDF1 TRMT1 UBAP2L RBMS2 YTHDF3

1.08e-04503205int:DDX6
InteractionCSDE1 interactions

YTHDF1 TRMT1 YTHDF3 KLC1

1.57e-04284204int:CSDE1
InteractionPUM1 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

1.63e-04287204int:PUM1
InteractionPRRC2C interactions

YTHDF1 UBAP2L YTHDF3 KLC1

1.70e-04290204int:PRRC2C
InteractionCNOT11 interactions

YTHDF1 UBAP2L YTHDF3

1.78e-04112203int:CNOT11
InteractionFUBP3 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

1.86e-04297204int:FUBP3
InteractionUBAP2L interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

1.88e-04298204int:UBAP2L
InteractionEIF4ENIF1 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

1.93e-04300204int:EIF4ENIF1
InteractionYTHDF1 interactions

YTHDF1 UBAP2L XRN2 YTHDF3

1.98e-04302204int:YTHDF1
InteractionUPF1 interactions

YTHDF1 UBAP2L XRN2 RBMS2 YTHDF3

2.12e-04581205int:UPF1
InteractionYTHDF2 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

2.24e-04312204int:YTHDF2
InteractionATXN2 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

2.24e-04312204int:ATXN2
InteractionZCCHC2 interactions

UBAP2L YTHDF3

2.34e-0423202int:ZCCHC2
InteractionSMG7 interactions

YTHDF1 UBAP2L XRN2 YTHDF3

2.44e-04319204int:SMG7
InteractionMARF1 interactions

YTHDF1 UBAP2L YTHDF3

2.64e-04128203int:MARF1
InteractionR3HDM2 interactions

UBAP2L RBMS2 YTHDF3

2.70e-04129203int:R3HDM2
InteractionSMC5 interactions

YTHDF1 UBAP2L PHF3 XRN2 RBMS2 YTHDF3

3.13e-041000206int:SMC5
InteractionFAM120A interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

3.44e-04349204int:FAM120A
InteractionBICC1 interactions

UBAP2L YTHDF3

3.48e-0428202int:BICC1
InteractionCNOT10 interactions

YTHDF1 UBAP2L YTHDF3

3.50e-04141203int:CNOT10
InteractionIGF2BP2 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

3.75e-04357204int:IGF2BP2
InteractionBMI1 interactions

YTHDF1 UBAP2L PHF3 XRN2 YTHDF3

3.79e-04659205int:BMI1
InteractionRC3H2 interactions

YTHDF1 UBAP2L XRN2 YTHDF3 ASPH

4.01e-04667205int:RC3H2
InteractionAGO3 interactions

YTHDF1 UBAP2L YTHDF3

4.45e-04153203int:AGO3
InteractionCPEB4 interactions

YTHDF1 UBAP2L YTHDF3

4.71e-04156203int:CPEB4
InteractionPABPC1 interactions

YTHDF1 UBAP2L RBMS2 YTHDF3 KLC1

4.97e-04699205int:PABPC1
InteractionPRRC2A interactions

YTHDF1 UBAP2L RBMS2 YTHDF3

5.18e-04389204int:PRRC2A
InteractionACE2 interactions

YTHDF1 TRMT1 UBAP2L XRN2 RBMS2 YTHDF3

5.37e-041106206int:ACE2
InteractionLSM12 interactions

YTHDF1 UBAP2L YTHDF3

5.45e-04164203int:LSM12
InteractionCEP85 interactions

YTHDF1 UBAP2L YTHDF3

5.95e-04169203int:CEP85
InteractionUBAP2 interactions

YTHDF1 UBAP2L YTHDF3

6.05e-04170203int:UBAP2
InteractionZCCHC14 interactions

UBAP2L YTHDF3

6.10e-0437202int:ZCCHC14
InteractionPATL1 interactions

YTHDF1 UBAP2L YTHDF3

6.80e-04177203int:PATL1
InteractionGIGYF1 interactions

MAP3K21 UBAP2L YTHDF3

6.80e-04177203int:GIGYF1
InteractionCNOT2 interactions

YTHDF1 UBAP2L YTHDF3

6.91e-04178203int:CNOT2
InteractionZNF598 interactions

TRMT1 UBAP2L YTHDF3 KLC1

7.88e-04435204int:ZNF598
InteractionQKI interactions

YTHDF1 RBMS2 YTHDF3

8.35e-04190203int:QKI
InteractionDOT1L interactions

YTHDF1 PHF3 XRN2 YTHDF3 ASPH

9.54e-04807205int:DOT1L
InteractionAGO2 interactions

YTHDF1 TRMT1 UBAP2L YTHDF3

1.07e-03472204int:AGO2
InteractionNOCT interactions

TRMT1 CRTAC1

1.07e-0349202int:NOCT
InteractionCNOT3 interactions

YTHDF1 UBAP2L YTHDF3

1.07e-03207203int:CNOT3
InteractionTDRD3 interactions

YTHDF1 UBAP2L YTHDF3

1.15e-03212203int:TDRD3
InteractionMCRIP2 interactions

YTHDF1 UBAP2L

1.16e-0351202int:MCRIP2
InteractionZC3H7A interactions

YTHDF1 UBAP2L YTHDF3

1.19e-03215203int:ZC3H7A
InteractionCLK1 interactions

MAP3K21 PHF3 KLC1

1.26e-03219203int:CLK1
InteractionANKRD17 interactions

YTHDF1 UBAP2L YTHDF3

1.38e-03226203int:ANKRD17
InteractionMCRIP1 interactions

YTHDF1 UBAP2L

1.45e-0357202int:MCRIP1
InteractionRPS20 interactions

YTHDF1 UBAP2L YTHDF3 KLC1

1.45e-03513204int:RPS20
InteractionCNOT9 interactions

YTHDF1 UBAP2L YTHDF3

1.47e-03231203int:CNOT9
InteractionOTUD4 interactions

YTHDF1 UBAP2L YTHDF3

1.56e-03236203int:OTUD4
InteractionPOT1 interactions

YTHDF1 XRN2 YTHDF3

1.58e-03237203int:POT1
InteractionMYCN interactions

YTHDF1 UBAP2L PHF3 XRN2 RBMS2 YTHDF3

1.67e-031373206int:MYCN
InteractionFMR1 interactions

YTHDF1 UBAP2L YTHDF3 KLC1

1.71e-03536204int:FMR1
InteractionRBMS2 interactions

UBAP2L RBMS2 YTHDF3

1.86e-03251203int:RBMS2
InteractionCNOT4 interactions

UBAP2L YTHDF3

1.87e-0365202int:CNOT4
InteractionPAN3 interactions

UBAP2L YTHDF3

1.87e-0365202int:PAN3
CytobandEnsembl 112 genes in cytogenetic band chr8q12

YTHDF3 ASPH

7.37e-0492202chr8q12
CytobandEnsembl 112 genes in cytogenetic band chr1q21

SEMA6C UBAP2L

1.32e-02404202chr1q21
CytobandEnsembl 112 genes in cytogenetic band chr12q13

NPFF RBMS2

1.44e-02423202chr12q13
Diseasedisease of metabolism (implicated_via_orthology)

YTHDF1 YTHDF3

8.19e-0521192DOID:0014667 (implicated_via_orthology)
Diseaseplatelet-to-lymphocyte ratio

RSPH6A KLC1 SCD5

1.55e-03363193EFO_0008446
Diseaseneutrophil percentage of granulocytes

RSPH6A SCD5

9.32e-03228192EFO_0007994
Diseaseeosinophil percentage of granulocytes

RSPH6A SCD5

9.80e-03234192EFO_0007996

Protein segments in the cluster

PeptideGeneStartEntry
QRAWGAQGQDRSFQR

CCDC187

461

A0A096LP49
WQQGRRNENACKGAP

ASPH

631

Q12797
QNQGKFVQNGRAWPR

RBMS2

226

Q15434
RRQQQQSGAWGAPRK

LRCH4

416

O75427
RQQWGTQKARNLFPG

ATG9B

891

Q674R7
RGNQGFNNNWLRVVP

CRTAC1

436

Q9NQ79
RNQQVQRGPRWNFFA

ENAM

351

Q9NRM1
ASFCGKRQQQQWPGR

KLC1

556

Q07866
QRNAPGWSQRGSLSQ

RSPH6A

51

Q9H0K4
RGLKRFQANPEANWG

TRMT1

546

Q9NXH9
WAGQVQRRLGIFPAN

MAP3K21

81

Q5TCX8
PGARGQRQNIVWRNV

SCD5

36

Q86SK9
FQPQRFGRNTQGSWR

NPFF

71

O15130
QNRWVAPRNRGAGFN

YTHDF3

351

Q7Z739
GTNRARGNWEQPQNQ

UBAP2L

6

Q14157
GFNPRWGQTLQFQLR

PLCD3

711

Q8N3E9
NGRQWKPQLGFNRDR

XRN2

791

Q9H0D6
WGRQDQQQLDRPFNR

PHF3

1901

Q92576
WNQNRNNAKEGPGRS

SEMA6C

721

Q9H3T2
TRWVAPRNRNAAFGQ

YTHDF1

326

Q9BYJ9