Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	anchoring junction	CLASP1 DSG2 AMBRA1 ECT2 ACTR3 FNDC1 FAT2 HEG1 G3BP1 PKN2 CTTN SCIN WNK4 WNK3	8.98e-05	976	92	14	GO:0070161
MousePheno	abnormal embryo development	THOC1 EFL1 FN1 EP400 FASTKD5 CHD8 ECT2 ACTR3 FREM2 LONP1 MGAT1 IPO9 G3BP1 STRAP PIK3C2A COPS8 FDFT1 XRN1 TMED2 PKN2 CTTN TOP2B	8.58e-06	1370	82	22	MP:0001672
Domain	DUF4939	RTL8B RTL8A RTL8C	1.64e-05	10	98	3	IPR032549
Domain	DUF4939	RTL8B RTL8A RTL8C	1.64e-05	10	98	3	PF16297
Domain	LDOC1-rel	RTL8B RTL8A RTL8C	2.24e-05	11	98	3	IPR032567
Domain	UCP038083_PDZ	GIPC2 GIPC3	8.15e-05	3	98	2	IPR017379
Domain	-	EFL1 LONP1 TOP2B	1.74e-04	21	98	3	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	EFL1 LONP1 TOP2B	2.01e-04	22	98	3	IPR014721
Domain	OSR1_C	WNK4 WNK3	4.03e-04	6	98	2	PF12202
Domain	Kinase_OSR1/WNK_CCT	WNK4 WNK3	4.03e-04	6	98	2	IPR024678
Domain	SNF2_N	ERCC6 EP400 CHD8	6.22e-04	32	98	3	IPR000330
Domain	SNF2_N	ERCC6 EP400 CHD8	6.22e-04	32	98	3	PF00176
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	THOC1 DNAJC13 EDC3 DNAJC21 ACTR3 DHX8 PARP4 G3BP1 STRAP PIK3C2A XRN1 PKN2 CTTN TOP2B NOL8 RBM17	2.05e-10	724	98	16	36232890
Pubmed	A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916).	RTL8B RTL8A RTL8C	2.17e-08	3	98	3	9403077
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	THOC1 DNAJC13 ERCC6 CLASP1 DNAJC21 ECT2 DHX8 G3BP1 STRAP BAZ1A XRN1 TOP2B NOL8 RBM17	2.97e-08	759	98	14	35915203
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EDC3 GIPC2 ERCC6 EP400 CLASP1 DSG2 MKRN1 DNAJC21 CHD8 ECT2 DHX8 RAB18 MGAT1 PIK3C2A BAZ1A BRD7 XRN1 TMED2 NOL8	3.35e-08	1497	98	19	31527615
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DNAJC13 ERCC6 FN1 EP400 AMBRA1 CHD8 ECT2 ACTR3 LONP1 IPO9 G3BP1 PIK3C2A BAZ1A TK1 XRN1 AKAP10 PKN2 TOP2B	4.00e-08	1353	98	18	29467282
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EDC3 EP400 DSG2 IARS2 RAB18 G3BP1 STRAP BAZ1A XRN1 PKN2 CTTN SCIN TOP2B NOL8 RBM17	5.60e-08	934	98	15	33916271
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	THOC1 FN1 EP400 CLASP1 DSG2 ACTR3 RAB18 IPO9 G3BP1 STRAP PIK3C2A BAZ1A BRD7 FBXO21 RBM47 PLOD2 RBM17	2.71e-07	1371	98	17	36244648
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	RTL8B RTL8A RTL8C	4.31e-07	6	98	3	35247097
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	THOC1 FASTKD5 ACTR3 LONP1 IARS2 RAB18 THADA IPO9 G3BP1 STRAP PIK3C2A FDFT1 TMED2 CTTN PLOD2 TOP2B RBM17	5.37e-07	1440	98	17	30833792
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DNAJC13 CLASP1 CHD8 ECT2 DHX8 PARP4 IPO9 BRD7 PKN2 CTTN RBM17	7.90e-07	582	98	11	20467437
Pubmed	A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.	RTL8B RTL8A RTL8C	3.52e-06	11	98	3	16093683
Pubmed	Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.	RTL8B RTL8A RTL8C	3.52e-06	11	98	3	15716091
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EDC3 CLASP1 KLHDC2 DSG2 PLEKHG2 ECT2 IPO9 PIK3C2A XRN1 PLEKHM3 WNK4 WNK3	5.68e-06	861	98	12	36931259
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	SHANK1 FN1 ECT2 G3BP1 STRAP XRN1 PLOD2 WNK4 WNK3	6.60e-06	462	98	9	31138677
Pubmed	A novel hypoxia-associated subset of FN1 high MITF low melanoma cells: identification, characterization, and prognostic value.	FN1 MITF	7.86e-06	2	98	2	24390218
Pubmed	WNKs are potassium-sensitive kinases.	WNK4 WNK3	7.86e-06	2	98	2	33439774
Pubmed	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation.	MKRN4P MKRN1	7.86e-06	2	98	2	30143610
Pubmed	An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.	MKRN4P MKRN1	7.86e-06	2	98	2	12721631
Pubmed	WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.	WNK4 WNK3	7.86e-06	2	98	2	18701621
Pubmed	Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma.	MKRN4P MKRN1	7.86e-06	2	98	2	19604354
Pubmed	Osmotic stress-induced remodeling of the cortical cytoskeleton.	ACTR3 CTTN	7.86e-06	2	98	2	12176742
Pubmed	The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans.	MKRN4P MKRN1	7.86e-06	2	98	2	16882727
Pubmed	Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals.	MKRN4P MKRN1	7.86e-06	2	98	2	16415359
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ERCC6 FN1 CLASP1 DNAJC21 KIAA0825 COPS8 CTTN MMP19 WNK4	1.18e-05	497	98	9	36774506
Pubmed	A protein interaction landscape of breast cancer.	THOC1 DSG2 LONP1 IARS2 STRAP COPS8 TK1 FDFT1 BRD7 TOP2B	1.25e-05	634	98	10	34591612
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DNAJC21 AMBRA1 CHD8 ECT2 FREM2 PARP4 XRN1 RNF216 PLCB3 RBM47	1.55e-05	650	98	10	38777146
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	AMBRA1 CHD8 ACTR3 LONP1 IPO9 G3BP1 XRN1 PKN2 CA8	2.08e-05	534	98	9	35032548
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	THOC1 EP400 CHD8 LONP1 RAB18 G3BP1 BRD7 RBM17	2.17e-05	410	98	8	26949251
Pubmed	Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling.	ACTR3 CTTN	2.35e-05	3	98	2	15242766
Pubmed	Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression.	OSCAR MITF	2.35e-05	3	98	2	12695521
Pubmed	Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas.	ECT2 CTTN	2.35e-05	3	98	2	21474972
Pubmed	The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.	WNK4 WNK3	2.35e-05	3	98	2	17975670
Pubmed	Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF.	MKRN4P MKRN1	2.35e-05	3	98	2	23104211
Pubmed	Whole exome sequencing discloses heterozygous variants in the DNAJC21 and EFL1 genes but not in SRP54 in 6 out of 16 patients with Shwachman-Diamond Syndrome carrying biallelic SBDS mutations.	EFL1 DNAJC21	2.35e-05	3	98	2	30198570
Pubmed	Interaction of cortactin and N-WASp with Arp2/3 complex.	ACTR3 CTTN	2.35e-05	3	98	2	12176354
Pubmed	The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.	MKRN4P MKRN1	2.35e-05	3	98	2	10843807
Pubmed	Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.	MKRN4P MKRN1	2.35e-05	3	98	2	24336050
Pubmed	p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin.	ACTR3 CTTN	2.35e-05	3	98	2	17576929
Pubmed	ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.	ACTR3 CTTN	2.35e-05	3	98	2	30562756
Pubmed	Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis.	MGAT1 B3GNT2	2.35e-05	3	98	2	27269286
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	FN1 CLASP1 HAP1 KIAA1549 ACTR3 RAB18 SNAP91 CTTN	3.05e-05	430	98	8	32581705
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	THOC1 EP400 DSG2 ACTR3 DHX8 LONP1 G3BP1 BAZ1A CTTN SCIN TOP2B RBM17	3.16e-05	1024	98	12	24711643
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SHANK1 DNAJC13 CLASP1 DSG2 FASTKD5 CHD8 RAB18 MGAT1 IPO9 FDFT1 RNF216 TOPORS TOP2B	3.35e-05	1203	98	13	29180619
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	DSG2 IARS2 IPO9 STRAP XRN1 CTTN	3.50e-05	216	98	6	31519766
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	EP400 AMBRA1 CHD8 G3BP1 BRD7 CTTN PLOD2 TOP2B	3.59e-05	440	98	8	34244565
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	DNAJC13 DNAJC21 ACTR3 G3BP1 STRAP CTTN	4.18e-05	223	98	6	33731348
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	EDC3 EP400 CLASP1 FASTKD5 DHX8 IARS2 STRAP COPS8 TK1 XRN1	4.30e-05	733	98	10	34672954
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	THOC1 DSG2 FASTKD5 ACTR3 DHX8 LONP1 IARS2 THADA IPO9 G3BP1 STRAP BAZ1A CTTN TOP2B	4.61e-05	1425	98	14	30948266
Pubmed	Global landscape of HIV-human protein complexes.	AMBRA1 PARP4 IPO9 G3BP1 STRAP COPS8 PLOD2 RBM17	4.68e-05	457	98	8	22190034
Pubmed	Activation of Arp2/3 complex-mediated actin polymerization by cortactin.	ACTR3 CTTN	4.70e-05	4	98	2	11231575
Pubmed	GIPC gene family (Review).	GIPC2 GIPC3	4.70e-05	4	98	2	12011974
Pubmed	miR-1207-3p regulates the androgen receptor in prostate cancer via FNDC1/fibronectin.	FN1 FNDC1	4.70e-05	4	98	2	27693493
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK4 WNK3	4.70e-05	4	98	2	34384519
Pubmed	Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation.	ACTR3 CTTN	4.70e-05	4	98	2	12732638
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK4 WNK3	4.70e-05	4	98	2	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK4 WNK3	4.70e-05	4	98	2	11498583
Pubmed	Shwachman-Diamond Syndrome	EFL1 DNAJC21	4.70e-05	4	98	2	20301722
Pubmed	PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration.	PLCB3 CTTN	4.70e-05	4	98	2	26490115
Pubmed	Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.	MKRN4P MKRN1	4.70e-05	4	98	2	11597136
Pubmed	SLC26A9 is a Cl(-) channel regulated by the WNK kinases.	WNK4 WNK3	4.70e-05	4	98	2	17673510
Pubmed	Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.	ACTR3 CTTN	4.70e-05	4	98	2	24469447
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	THOC1 DNAJC21 ACTR3 DHX8 LONP1 RAB18 IPO9 G3BP1 PIK3C2A XRN1 CTTN TOPORS RBM17	4.84e-05	1247	98	13	27684187
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	THOC1 ERCC6 DSG2 DNAJC21 ECT2 ACTR3 DHX8 IARS2 G3BP1 STRAP CTTN TOPORS NOL8	5.25e-05	1257	98	13	36526897
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	EP400 CLASP1 DNAJC21 CHD8 ACTR3 DHX8 BAZ1A BRD7	5.87e-05	472	98	8	38943005
Pubmed	Interaction network of human early embryonic transcription factors.	EP400 CHD8 LONP1 BAZ1A BRD7 MITF PRDM16	6.33e-05	351	98	7	38297188
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	THOC1 DNAJC13 EP400 CLASP1 G3BP1 PKN2 PLCB3 CTTN TOPORS TOP2B	6.76e-05	774	98	10	15302935
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERCC6 EP400 DSG2 KIAA1549 AMBRA1 FASTKD5 CHD8 THADA BRD7 XRN1 TOPORS PRDM16	7.21e-05	1116	98	12	31753913
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC13 DSG2 KIAA1549 DNAJC21 FASTKD5 IARS2 THADA PIK3C2A FDFT1 TMED2 PKN2 PLOD2 TOP2B NOL8	7.27e-05	1487	98	14	33957083
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	THOC1 DSG2 DHX8 LONP1 G3BP1 STRAP COPS8 BRD7 CTTN TOP2B	7.68e-05	786	98	10	29128334
Pubmed	Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.	WNK4 WNK3	7.82e-05	5	98	2	24641320
Pubmed	SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage.	GBP6 G3BP1	7.82e-05	5	98	2	34296442
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PARP4 THADA FAT2 ZBTB39 IPO9 GRIN3A SCIN PRDM16	7.95e-05	493	98	8	15368895
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	THOC1 EP400 CHD8 G3BP1 SNAP91 BAZ1A BRD7 CTTN TOP2B NOL8 RBM17	7.97e-05	954	98	11	36373674
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	EDC3 CLASP1 DSG2 AMBRA1 ECT2 ACTR3 STRAP BRD7 TMED2 PLOD2 TOP2B RBM17	9.97e-05	1155	98	12	20360068
Pubmed	Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation.	OSCAR MITF	1.17e-04	6	98	2	16322470
Pubmed	K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.	EDC3 XRN1	1.17e-04	6	98	2	27315556
Pubmed	Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.	MKRN4P MKRN1	1.17e-04	6	98	2	19536131
Pubmed	Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes.	CHD8 AKAP10	1.17e-04	6	98	2	7505766
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	DNAJC13 CLASP1 DSG2 ACTR3 IARS2 IPO9 G3BP1 PIK3C2A TK1 FDFT1 TMED2 CTTN RBM17	1.22e-04	1367	98	13	32687490
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DNAJC13 ERCC6 DSG2 DHX8 G3BP1 STRAP BAZ1A TOP2B NOL8 RBM17	1.41e-04	847	98	10	35850772
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	EDC3 DSG2 MKRN1 DNAJC21 LONP1 THADA IPO9 STRAP NOL8	1.46e-04	689	98	9	36543142
Pubmed	Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.	CHD8 BAZ1A	1.64e-04	7	98	2	26816381
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK4 WNK3	1.64e-04	7	98	2	20525693
Pubmed	The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells.	GIPC2 GIPC3	1.64e-04	7	98	2	26013465
Pubmed	Human transcription factor protein interaction networks.	EDC3 EP400 CHD8 ACTR3 LONP1 G3BP1 STRAP BRD7 MITF XRN1 TMED2 CTTN PRDM16	1.88e-04	1429	98	13	35140242
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	DSG2 ACTR3 LONP1 IARS2 IPO9 G3BP1 STRAP TMED2 CTTN PLOD2	1.89e-04	878	98	10	37223481
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK4 WNK3	2.18e-04	8	98	2	23838290
Pubmed	Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.	ACTR3 CTTN	2.18e-04	8	98	2	11018051
Pubmed	Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.	MKRN4P MKRN1	2.18e-04	8	98	2	15522233
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK4 WNK3	2.18e-04	8	98	2	23387299
Pubmed	The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts.	ACTR3 CTTN	2.18e-04	8	98	2	22349694
Pubmed	Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.	COPS8 WNK4	2.18e-04	8	98	2	26286618
Pubmed	IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.	WNK4 WNK3	2.18e-04	8	98	2	21317537
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FN1 FASTKD5 CHD8 LONP1 IARS2 RAB18 MGAT1 HEG1 UBA7 AEBP1 TMED2 CTTN PLOD2	2.19e-04	1451	98	13	30550785
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	AMBRA1 CHD8 IPO9 COPS8 PLCB3	2.57e-04	199	98	5	36688959
Pubmed	SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.	AMBRA1 ACTR3 IARS2 FBXO21	2.72e-04	110	98	4	28883622
Pubmed	CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.	ERCC6 COPS8	2.79e-04	9	98	2	16751180
Pubmed	Exocrine glands and the Chievitz organ of some mouse mutants.	FREM2 MITF	2.79e-04	9	98	2	5088022
Pubmed	Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.	G3BP1 XRN1	2.79e-04	9	98	2	18625844
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	CHD8 IPO9 BRD7	3.02e-04	46	98	3	30419336
Cytoband	5q33.1	FAT2 G3BP1	1.42e-03	26	98	2	5q33.1
Cytoband	1p22.2	GBP6 PKN2	1.64e-03	28	98	2	1p22.2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 NCKAP5 FNDC1 MITF SRL GRIN3A	2.10e-06	170	98	6	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	NAT16 HEG1 MITF SCIN WNK3	3.51e-05	168	98	5	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	COVID-19-lung-MAST\|lung / Disease (COVID-19 only), tissue and cell type	KIAA1549 CASQ1 PARP4 MITF SCIN	3.71e-05	170	98	5	e90f18e5462381b38e918442b38b1c8105291908
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DSG2 SCIN PRDM16 WNK3 CA8	4.15e-05	174	98	5	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DSG2 SCIN PRDM16 WNK3 CA8	4.38e-05	176	98	5	25ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	FN1 FNDC1 HEG1 AEBP1 MMP19	4.62e-05	178	98	5	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|bone_marrow / Manually curated celltypes from each tissue	PF4V1 DNAAF3 MITF CTTN PLOD2	5.13e-05	182	98	5	1a755ea44daf8447a3a1c30de7fdb9c3888bcbde
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERCC6 PF4V1 KIAA0825 MMP19 PRDM16	5.27e-05	183	98	5	5377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CLASP1 MITF SCIN PRDM16 WNK4	5.27e-05	183	98	5	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 DNAAF3 FNDC1 AEBP1 SRL	5.41e-05	184	98	5	264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 DNAAF3 FNDC1 AEBP1 SRL	5.41e-05	184	98	5	d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 DNAAF3 FNDC1 AEBP1 SRL	5.41e-05	184	98	5	22010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell	facs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 HEG1 ZBTB39 WNK4 CA8	5.84e-05	187	98	5	d9943e65eedab73d141eae524e2411653a751705
ToppCell	facs-Heart-LA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 HEG1 ZBTB39 WNK4 CA8	5.84e-05	187	98	5	7b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	NCKAP5 SNAP91 MITF SRL PRDM16	5.84e-05	187	98	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	droplet-Bladder-nan-24m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GIPC2 BAZ1A FDFT1 CTSE RBM47	6.30e-05	190	98	5	725657faf90b8ef0a286a3fd64ed18ab600aa2df
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|World / Lineage and Cell class	GIPC3 ABHD4 DNAAF3 RTL8B PLOD2	6.30e-05	190	98	5	1d19b2bd55789bf13e1386332f46c605973d6f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 DNAJC21 ACTR3 PKN2 TOP2B	6.45e-05	191	98	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 NCKAP5 FNDC1 HEG1 AEBP1	6.45e-05	191	98	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FN1 OSCAR MGAT1 TMED2 MMP19	6.45e-05	191	98	5	cf217d00ba2b0402a8e72fcd64bdb36d5539dde0
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 DNAJC21 ACTR3 PKN2 TOP2B	6.45e-05	191	98	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 DNAJC21 ACTR3 PKN2 TOP2B	6.45e-05	191	98	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 DSG2 ZBTB39 WNK4 CA8	6.61e-05	192	98	5	14a816ef116aa992f86edab411f043cf7d07fe04
ToppCell	facs-Lung-EPCAM-18m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GIPC2 DSG2 FAT2 RBM47 CA8	6.61e-05	192	98	5	12096302a3a4d26e21ca04357aa557143f482155
ToppCell	facs-Heart-LA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 DSG2 ZBTB39 WNK4 CA8	6.61e-05	192	98	5	847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FN1 OSCAR MGAT1 TMED2 MMP19	6.95e-05	194	98	5	12e42433a7b7c17c46049ef450223daf2976a59a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	VWA5B2 FREM2 RBM47 PRDM16 CA8	6.95e-05	194	98	5	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	IPF-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	FN1 MGAT1 MITF RBM47 MMP19	7.12e-05	195	98	5	50edda117b438b9c3616191884007466f6d974f0
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	OSCAR MGAT1 MITF RBM47 MMP19	7.12e-05	195	98	5	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	3'_v3-Lung\|World / Manually curated celltypes from each tissue	FN1 OSCAR MITF RBM47 MMP19	7.29e-05	196	98	5	a04f8384b734ce67ec402e64bd891a6274f04744
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FN1 FNDC1 HEG1 AEBP1 CA8	7.29e-05	196	98	5	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DSG2 FNDC1 SVOP WNK4 WNK3	7.47e-05	197	98	5	88a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DSG2 FNDC1 SVOP WNK4 WNK3	7.47e-05	197	98	5	2773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 FNDC1 HEG1 MITF RTL8C	7.83e-05	199	98	5	3cf62666ffd000427fdbb7cf940793f98c3ed29c
ToppCell	MS-Multiple_Sclerosis-Others\|Multiple_Sclerosis / Disease, condition lineage and cell class	MKRN1 PF4V1 DNAAF3 CTTN PLOD2	8.02e-05	200	98	5	3aa674db6c3e999d8175dd1e9349c18d15ec4e9b
Drug	CQ-S	CASQ1 FDFT1 B3GNT2 TOP2B	7.36e-07	17	98	4	CID000072462
Disease	Shwachman syndrome	EFL1 DNAJC21	6.00e-05	4	94	2	cv:C0272170
Disease	latent autoimmune diabetes in adults	THADA RBM17	6.00e-05	4	94	2	EFO_0009706
Disease	Shwachman syndrome	EFL1 DNAJC21	6.00e-05	4	94	2	C0272170
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK4 WNK3	1.49e-04	6	94	2	DOID:4479 (implicated_via_orthology)
Disease	coronary artery disease	DNAJC13 FN1 DNAAF3 FNDC1 THADA COPS8 B3GNT2 MITF PKN2 FBXO21 RBM47 PRDM16	4.09e-04	1194	94	12	EFO_0001645
Disease	myocardial infarction	FN1 ANKUB1 THADA IPO9 MITF PRDM16	9.05e-04	350	94	6	EFO_0000612
Disease	mean reticulocyte volume	EP400 CLASP1 LONP1 THADA TK1 FDFT1 B3GNT2 SRL PRDM16	1.02e-03	799	94	9	EFO_0010701
Disease	brain infarction	GIPC2 RBM47	1.49e-03	18	94	2	EFO_0004277
Disease	white matter lesion progression measurement	GIPC2 DNAAF3 FNDC1	1.53e-03	71	94	3	EFO_0007746
Disease	brain measurement, neuroimaging measurement	VWA5B2 NCKAP5 DNAAF3 THADA MITF AKAP10 PRDM16	1.91e-03	550	94	7	EFO_0004346, EFO_0004464
Disease	neuroimaging measurement	VWA5B2 NCKAP5 DNAAF3 THADA G3BP1 SNAP91 BAZ1A MITF AKAP10 PRDM16	2.16e-03	1069	94	10	EFO_0004346
Disease	colorectal carcinoma (is_implicated_in)	ERCC6 STRAP	2.23e-03	22	94	2	DOID:0080199 (is_implicated_in)
Disease	mean corpuscular hemoglobin concentration	DNAJC13 GIPC2 EP400 CLASP1 LONP1 BAZ1A B3GNT2 PKN2 PLCB3 PRDM16	2.74e-03	1105	94	10	EFO_0004528
Disease	cortical thickness	VWA5B2 NCKAP5 DNAAF3 THADA G3BP1 KIAA0825 SNAP91 BAZ1A MITF AKAP10	2.88e-03	1113	94	10	EFO_0004840

Protein segments in the cluster

Peptide	Gene	Start	Entry
DDAGFPVKAEEFVVL	EP400	2071	Q96L91
FFVENPSEEDAAIVD	CHD8	631	Q9HCK8
NFGVPVEVFDSEEAE	BRD7	526	Q9NPI1
FDEAIIVDAASLDPE	AKAP10	561	O43572
EEKEEEIATGQAFPF	AEBP1	1131	Q8IUX7
AVLPVAESFGFADEI	EFL1	1026	Q7Z2Z2
DPEGAEDEFVTSIET	ABHD4	116	Q8TB40
LDETLGDFAFPDEFV	GIPC2	286	Q8TF65
VLGEFAFPDEFVVEV	GIPC3	286	Q8TF64
LDIFGDLFESTPEVA	SNAP91	561	O60641
GPSVEGTDLEFEDFE	AMBRA1	766	Q9C0C7
EIDDDFFPSSGEEAE	ERCC6	421	Q03468
DEFPDGVTLEVLEEA	BAZ1A	446	Q9NRL2
PFDDEEEAVTFELGE	MKRN4P	466	Q13434
DTFDPELAATIGVDF	RAB18	31	Q9NP72
DVYEDELVPVFEAVG	RBM47	81	A0AV96
ESVEEFEGLDSPEFE	ECT2	111	Q9H8V3
FEGLDSPEFENVFVV	ECT2	116	Q9H8V3
SVVADFSEFEEDPQV	KIAA1549	466	Q9HCM3
EPVFTQDVFVGSVEE	DSG2	156	Q14126
EIDDDFFPSSGEEAE	ERCC6	421	P0DP91
FSDIENLEGPEIFFE	FBXO21	131	O94952
FPGDLEFEQIFSDID	KIAA0825	21	Q8IV33
VVVEDDLEVAPDFFE	MGAT1	206	P26572
ELEVVDLEGAASDPF	FREM2	411	Q5SZK8
EPGQTFVDAEFDGIL	CTSE	171	P14091
LFSASEFEDPLVGED	FDFT1	186	P37268
PVVVAFARAEAEEDG	PF4V1	26	P10720
ALPLEIFITVGEDEF	FAT2	3531	Q9NYQ8
DIPELGSVHFDEDEF	MMP19	181	Q99542
EGQIEPSFVFRTFDE	PIK3C2A	1451	O00443
FEFPEDSEGIIVISS	SLC10A3	76	P09131
EPLDFVVATEREFEE	NAT16	51	Q8N8M0
EIFDIAFPDEQAEAL	LONP1	941	P36776
DGVEDSTEFVSFFPD	GBP6	161	Q6ZN66
IEEIPDTDFDFEGNL	EDC3	196	Q96F86
PGDEEFIEPSTENEF	HEG1	391	Q9ULI3
SDPFEVVRDDFKSGV	NOL8	331	Q76FK4
EVSEDFEEDGLGVLP	PARP4	1256	Q9UKK3
VDDISPALEVTEEFF	PLEKHM3	6	Q6ZWE6
VLEEEVDDFPTFGDS	DNAJC21	126	Q5F1R6
IDEGQFFPDIVEFCE	TK1	96	P04183
TECFDVIFAGGPEEV	PLOD2	111	O00469
IEHPFVFTREVDDEG	GRIN3A	521	Q8TCU5
ELAEFFLEEVTPAQG	OSCAR	81	Q8IYS5
DVEEPTIFQEDAGGF	ITGAD	21	Q13349
SFDPFTEVIVDGIVA	PLCB3	711	Q01970
DDLDFFIGDEAIEKP	ACTR3	56	P61158
PRATGVDEEDVEVFD	FASTKD5	96	Q7L8L6
PFVAFGIEADDESLL	DNAAF3	281	Q8N9W5
GEGIPIFEDFVDSSV	FN1	1306	P02751
EVFGGFVTEPQEESE	G3BP1	136	Q13283
EGAISSFPEEEFDLA	FNDC1	1591	Q4ZHG4
VAFAEEADPDGFEFL	CASQ1	286	P31415
GEDFTPAEEFVPQEE	HAP1	551	P54257
FIEDTVAFPEKEEDE	CA8	6	P35219
EKFSEIFLGEFDTPE	DNAJC13	1186	O75165
VEDPVDSDGEVLGFE	IPO9	316	Q96P70
LPEDKVLGTFEFDET	KLHDC2	166	Q9Y2U9
DDFAAFVGLPVEEAV	COPS8	131	Q99627
LSKEEFPDFDEETGI	DHX8	411	Q14562
PFDNDEEEVVTFELG	MKRN1	431	Q9UHC7
ETFDGDTDRLPEFIV	RTL8A	31	Q9BWD3
ETFDGDTDRLPEFIV	RTL8B	31	Q17RB0
ETFDGDTDRLPEFIV	RTL8C	31	A6ZKI3
EAVELDDGAAVPKEF	SVOP	46	Q8N4V2
VEGADFVPDPFFVEL	THADA	426	Q6YHU6
KVEFDEEFSGAPVEG	TOP2B	1271	Q02880
CVTVIFDAEDGEPIE	NCKAP5	666	O14513
FVIEEIPGEFTQDDL	SCIN	626	Q9Y6U3
EEDEEPAASLAVGFD	PRDM16	1156	Q9HAZ2
TEARFPDVANGFIEE	RNF216	291	Q9NWF9
VDEDGVFTDVAGPEL	IARS2	416	Q9NSE4
PFPGDDEEEVFDSIV	PKN2	856	Q16513
GFPETTEEELEEIAS	STRAP	321	Q9Y3F4
APSVDVEDGEFLFVE	SHANK1	1551	Q9Y566
TPEEILFEDAFDVAS	STRA8	241	Q7Z7C7
PDTEFVFKGDDDVFV	B3GNT2	236	Q9NY97
FEPFDVSADETVEVV	ANKUB1	11	A6NFN9
AVDEEDFIKAFDDVP	CLASP1	296	Q7Z460
GIVPDFEVGEEFHEE	MITF	6	O75030
DFGEDFTVQDPTEAE	UBA7	161	P41226
AGDDEISFDPDDIIT	CTTN	506	Q14247
GAPDDEAVRIFLEFE	RBM17	346	Q96I25
FSDGELVFKDIVEDP	SRL	361	Q86TD4
ADVLFEVLFDEEFPG	XRN1	1136	Q8IZH2
EPVTFEDVAVDFTQE	ZNF630	6	Q2M218
FEDPAEDIGTTEEVI	ZBTB39	306	O15060
SAEGLSEEVPVVFEE	ZNF862	316	O60290
IFEVAEGGFLDIDVE	TMED2	46	Q15363
VTFEDVLVDFSPEEL	ZIM2	176	Q9NZV7
YPLAEAEVVSGFEAE	VWA5B2	51	Q8N398
PFETKDVVTIEAEFG	TOPORS	946	Q9NS56
LAPLAEEEDDVEFSG	SCN11A	916	Q9UI33
LEAKVEAFGDFSPEV	TTC23	341	Q5W5X9
GPEEDEEGVSFTDFQ	PLEKHG2	731	Q9H7P9
VTFRFDLDGDSPEEI	WNK4	701	Q96J92
PTLEEFFEEAIEQAD	THOC1	461	Q96FV9
VTFKFDVDGDAPEDI	WNK3	771	Q9BYP7
EDTEIEGLEVPFIDS	NLRP13	501	Q86W25