Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoHead titubation

SPG11 SPTBN1 TMEM63A

1.68e-0525113HP:0002599
HumanPhenoTitubation

SPG11 SPTBN1 TMEM63A

5.59e-0537113HP:0030187
HumanPhenoAbnormal head movements

SPG11 SPTBN1 TMEM63A

8.22e-0542113HP:0002457
HumanPhenoHead tremor

SPG11 SPTBN1 TMEM63A

1.15e-0447113HP:0002346
HumanPhenoOverweight

SPG11 THOC2 SPTBN1

1.31e-0449113HP:0025502
DomainANK

POTEJ POTEB2 POTEH POTEB

5.81e-04251294SM00248
DomainANK_REPEAT

POTEJ POTEB2 POTEH POTEB

5.98e-04253294PS50088
DomainAnkyrin_rpt-contain_dom

POTEJ POTEB2 POTEH POTEB

6.07e-04254294IPR020683
DomainANK_REP_REGION

POTEJ POTEB2 POTEH POTEB

6.07e-04254294PS50297
DomainAnkyrin_rpt

POTEJ POTEB2 POTEH POTEB

6.82e-04262294IPR002110
DomainPH

VAV3 DOCK11 ELMO1 SPTBN1

8.51e-04278294SM00233
DomainPH_DOMAIN

VAV3 DOCK11 ELMO1 SPTBN1

8.62e-04279294PS50003
DomainPH_domain

VAV3 DOCK11 ELMO1 SPTBN1

8.74e-04280294IPR001849
Domain-

VAV3 DOCK11 ELMO1 SPTBN1

2.97e-033912942.30.29.30
DomainPH_dom-like

VAV3 DOCK11 ELMO1 SPTBN1

4.03e-03426294IPR011993
DomainAnk_2

POTEJ POTEB2 POTEH

4.41e-03215293PF12796
DomainCH

VAV3 SPTBN1

4.56e-0365292SM00033
DomainAnk

POTEJ POTEH POTEB

5.19e-03228293PF00023
DomainPH

VAV3 DOCK11 SPTBN1

5.25e-03229293PF00169
DomainCH

VAV3 SPTBN1

5.27e-0370292PF00307
Domain-

VAV3 SPTBN1

5.41e-03712921.10.418.10
DomainTPR-like_helical_dom

IFT140 ATR TTC38

5.51e-03233293IPR011990
DomainCH

VAV3 SPTBN1

5.71e-0373292PS50021
DomainCH-domain

VAV3 SPTBN1

6.02e-0375292IPR001715
Domain-

POTEJ POTEB2 POTEH

6.55e-032482931.25.40.20
DomainARM-type_fold

ATR DOCK11 ELMO1

1.53e-02339293IPR016024
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEJ POTEB2 POTEH POTEB

3.14e-11830412475935
Pubmed

Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.

POTEB2 POTEH POTEB

1.16e-08630317171436
Pubmed

Identification and characterization of TSAP, a novel gene specifically expressed in testis during spermatogenesis.

POTEH POTEB

4.31e-06430217342726
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

POTEJ POTEB2 POTEH POTEB

1.16e-0516330424316575
Pubmed

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

POTEH POTEB

1.51e-05730215276201
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

ADNP2 MAB21L2 SNRNP200 PATZ1 TMEM63A

2.51e-0541130535182466
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MCM4 UTP18 ATR THOC2 SNRNP200 SPTBN1

4.48e-0577430615302935
Pubmed

A human MAP kinase interactome.

ADNP2 IFT140 VAV3 SNRNP200 SPTBN1

5.57e-0548630520936779
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

MCM4 POTEJ THOC2 SPTBN1

8.42e-0527130432433965
Pubmed

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

MCM4 ATR

1.09e-041830228191891
Pubmed

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.

MCM4 ATR

1.64e-042230215707391
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

ATR THOC2 SNRNP200 SPTBN1

2.01e-0434030424332808
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

MCM4 VAV3 SNRNP200 SPTBN1

2.10e-0434430430333137
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MCM4 UTP18 THOC2 SNRNP200 SPTBN1

2.22e-0465330522586326
Pubmed

Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.

SNRNP200 TCEAL4 SPTBN1

3.17e-0415430336490346
Pubmed

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

MCM4 ATR

3.97e-043430212791985
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

POTEJ SNRNP200 SPTBN1

4.16e-0416930323084401
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

MCM4 NR1I2 SNRNP200 TCEAL4 SPTBN1

4.30e-0475430535906200
Pubmed

Cellular substrates and pro-apoptotic function of the human HtrA4 protease.

ADK MCM4 SNRNP200

4.45e-0417330331470122
Pubmed

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.

MCM4 SPTBN1

6.35e-044330234672947
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

POTEJ THOC2 SNRNP200

6.98e-0420230324639526
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

MCM4 ATR SNRNP200 SPTBN1

7.22e-0447730431300519
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEJ POTEB2 POTEH POTEB

1.41e-0913234685
GeneFamilyAnkyrin repeat domain containing

POTEJ POTEB2 POTEH POTEB

2.27e-04242234403
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

VAV3 DOCK11 SPTBN1

2.18e-03206233682
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_B

VAV3 POTEJ POTEB2 POTEH POTEB ELMO1 SPTBN1

3.43e-06584307MM1080
CoexpressionDARWICHE_PAPILLOMA_PROGRESSION_RISK

MCM4 POTEB2 POTEH POTEB

3.63e-0692304MM503
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000

TUBE1 DOCK11 EPYC PATZ1 SPTBN1

2.43e-05259295gudmap_developingGonad_e12.5_epididymis_k3_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_500

TUBE1 DOCK11 PATZ1 SPTBN1

6.68e-05162294gudmap_developingGonad_e16.5_epididymis_500_k2
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000

THOC2 TUBE1 DOCK11 PATZ1 SPTBN1

6.95e-05323295gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#4_top-relative-expression-ranked_500

TUBE1 DOCK11 PATZ1 SPTBN1

9.01e-05175294gudmap_developingGonad_e14.5_ epididymis_500_k4
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_500

ATR THOC2 DOCK11 ZNF541 SPTBN1

1.62e-04387295gudmap_developingGonad_e16.5_ovary_500
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#2_top-relative-expression-ranked_1000

THOC2 DOCK11 PATZ1 SPTBN1

2.57e-04230294gudmap_developingGonad_e16.5_ovary_1000_k2
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#5_top-relative-expression-ranked_500

THOC2 DOCK11 SPTBN1

4.36e-04109293gudmap_developingGonad_e16.5_ovary_500_k5
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_1000

TUBE1 DOCK11 PATZ1 SPTBN1

5.21e-04277294gudmap_developingGonad_e12.5_ovary_k3_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000

TUBE1 DOCK11 PATZ1 SPTBN1

5.49e-04281294gudmap_developingGonad_e18.5_epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

ATR THOC2 DOCK11 PATZ1 ZNF541 SPTBN1

6.14e-04795296gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000

THOC2 TUBE1 DOCK11 EPYC PATZ1 SPTBN1

6.30e-04799296gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

THOC2 TUBE1 DOCK11 EPYC PATZ1 SPTBN1

6.38e-04801296gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000

THOC2 TUBE1 DOCK11 TTC38 PATZ1 SPTBN1

6.51e-04804296gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

THOC2 TUBE1 DOCK11 EPYC PATZ1 SPTBN1

6.60e-04806296gudmap_developingGonad_e12.5_epididymis_1000
Diseaseeosinophil count

MCM4 VAV3 ATR THOC2 SNRNP200 PATZ1 ELMO1 SPTBN1

1.46e-051488248EFO_0004842
Diseaseretinitis pigmentosa (is_implicated_in)

IFT140 SNRNP200

5.10e-0441242DOID:10584 (is_implicated_in)
Diseaseage-related hearing impairment

ADK CCDC122 SPTBN1

2.24e-03324243EFO_0005782
Diseaseeosinophil percentage of leukocytes

MCM4 VAV3 PATZ1 ELMO1

2.88e-03746244EFO_0007991
DiseaseRetinitis Pigmentosa

IFT140 SNRNP200

3.23e-03104242C0035334
Diseaseautoimmune thyroid disease

VAV3 ELMO1

4.70e-03126242EFO_0006812
Diseaseautoimmune disease

VAV3 ELMO1

8.67e-03173242EFO_0005140

Protein segments in the cluster

PeptideGeneStartEntry
LDNMLYFAKHHQDAY

ELMO1

381

Q92556
LKRKAAEAHVDAHYY

ADK

116

P55263
LYYSMKKHVLVAHFH

ADNP2

166

Q6IQ32
SHHMNDELVLYYKKI

IQCH

496

Q86VS3
LHYAIYNEDKLMAKA

POTEB2

206

H3BUK9
LLDMAVLKDYIAYAH

MCM4

681

P33991
EAFKDMYDLHHLYLT

EPYC

231

Q99645
FHYMLKKLQLHEEEY

NR1I2

326

O75469
LKHMVDRHNLYFVYL

TMEM63A

641

O94886
YLRAAYMADHLKKHS

PATZ1

476

Q9HBE1
EDGHFYLAKYYDKLM

ATR

2036

Q13535
ELKMLDKYSHYLAAE

DOCK11

241

Q5JSL3
HMIKYNAYYAKIKAH

CCDC122

121

Q5T0U0
DKYHALYMDALHKLF

AWAT1

296

Q58HT5
NYHMKTLLLYECEKH

MAB21L2

271

Q9Y586
MLYHKAGHFSKALEL

IFT140

1086

Q96RY7
EKGKALMYRLHHYSD

UTP18

541

Q9Y5J1
LHYAIYNEDKLMAKA

POTEB

206

A0A0A6YYL3
LHYAIYNEDKLMAKA

POTEJ

206

P0CG39
LAASYELHKFYHDAK

SPTBN1

1801

Q01082
EMTYIFDLLHKKHYF

SPG11

2171

Q96JI7
HYLKEYKEAIHDMNF

TCEAL4

136

Q96EI5
MYAHHISSKYDELKK

THOC2

821

Q8NI27
FMRLYKKKAHLHHYL

TUBE1

416

Q9UJT0
HEYFLLKAKYAQDEH

SNRNP200

1236

O75643
DMLALKFSHDAYFYL

TTC38

141

Q5R3I4
MLFLLYLHFAYHKVV

YIPF3

286

Q9GZM5
HYAIYNEDKLMAKAL

POTEH

281

Q6S545
AFYAHKKDFYLIHKM

ZNF541

1176

Q9H0D2
FKSLMELVEYYKHHS

VAV3

736

Q9UKW4