Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

DST NRAP SSH1 MYO1D MYO7A SPTA1 SPTB DAAM2 INO80 MYBPC1 ARPC2

1.02e-054799011GO:0003779
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

SPTA1 SPTB TUBE1 BFSP1 MYBPC1 ARPC2

2.70e-05130906GO:0005200
GeneOntologyCellularComponentaxon

DST SSH1 MYO1D NRXN1 TENM3 USP9X SPTA1 DOCK7 PLXND1 DCLK1 ADGRL3 ARPC2

4.29e-048919012GO:0030424
GeneOntologyCellularComponentspectrin-associated cytoskeleton

SPTA1 SPTB

6.47e-049902GO:0014731
GeneOntologyCellularComponentspectrin

SPTA1 SPTB

6.47e-049902GO:0008091
GeneOntologyCellularComponentgrowth cone

SSH1 NRXN1 USP9X DOCK7 DCLK1 ARPC2

6.68e-04245906GO:0030426
GeneOntologyCellularComponentglutamatergic synapse

NRXN1 TENM3 SPTB RIMS1 PLXND1 GRIN3A ELMOD1 DCLK1 ADGRL3 ARPC2 FGF22

7.58e-048179011GO:0098978
GeneOntologyCellularComponentsite of polarized growth

SSH1 NRXN1 USP9X DOCK7 DCLK1 ARPC2

7.89e-04253906GO:0030427
GeneOntologyCellularComponenthemidesmosome

EPPK1 DST

9.83e-0411902GO:0030056
GeneOntologyCellularComponentcell-cell junction

EPPK1 DST NRAP NRXN1 AMOTL1 TNKS1BP1 KAZN OCLN ADGRL3

1.00e-03591909GO:0005911
GeneOntologyCellularComponentcell cortex

DST MYO1D MYO7A SPTA1 SPTB RIMS1 BFSP1

1.11e-03371907GO:0005938
GeneOntologyCellularComponentphotoreceptor connecting cilium

MYO7A KIAA1549 ALPK1

1.16e-0348903GO:0032391
MousePhenocerebral infarct

SPTA1 SPTB

2.99e-052772MP:0021003
MousePhenoabnormal lateral ventricle morphology

BICD2 ARHGAP5 CHD7 TDO2 SPAG17 CCDC39 TP73

3.25e-05164777MP:0000823
DomainSpectrin

DST SPTA1 SPTB

1.85e-0423913PF00435
DomainTMEM132

TMEM132C TMEM132B

2.33e-045912PF16070
DomainTMEM132D_N

TMEM132C TMEM132B

2.33e-045912PF15705
DomainTMEM132D_C

TMEM132C TMEM132B

2.33e-045912PF15706
DomainTMEM132_M

TMEM132C TMEM132B

2.33e-045912IPR031437
DomainTMEM132_C

TMEM132C TMEM132B

2.33e-045912IPR031436
DomainTMEM132_N

TMEM132C TMEM132B

2.33e-045912IPR031435
DomainTMEM132

TMEM132C TMEM132B

2.33e-045912IPR026307
Domain-

EPPK1 DST

3.48e-0469123.90.1290.10
DomainSpectrin_repeat

DST SPTA1 SPTB

3.73e-0429913IPR002017
DomainPlectin_repeat

EPPK1 DST

4.85e-047912IPR001101
DomainPlectin

EPPK1 DST

4.85e-047912PF00681
DomainPLEC

EPPK1 DST

4.85e-047912SM00250
DomainSpectrin/alpha-actinin

DST SPTA1 SPTB

5.01e-0432913IPR018159
DomainSPEC

DST SPTA1 SPTB

5.01e-0432913SM00150
Domain-

SWT1 EXO1

1.50e-03129123.40.50.1010
DomainPIN_domain-like

SWT1 EXO1

2.06e-0314912IPR029060
DomainActinin_actin-bd_CS

DST SPTB

5.56e-0323912IPR001589
DomainACTININ_2

DST SPTB

5.56e-0323912PS00020
DomainACTININ_1

DST SPTB

5.56e-0323912PS00019
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PPP1R7 ARHGAP5 DST MYO1D SND1 MYO7A UBAP2L USP9X SPTA1 SPTB DOCK7 KIAA1549 MTMR1 TNKS1BP1 RIMS1 PLCH1 ELP3 DCLK1 ARCN1 ARPC2

8.37e-101431922037142655
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

MB21D2 DST SND1 UBAP2L USP9X DOCK7 SLITRK5 MTMR1 ANKRD17 TNKS1BP1 OCLN PLCH1 ARCN1

4.72e-08708921339231216
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

PPP1R7 DST SSH1 NRXN1 UBAP2L USP9X DOCK7 ANKRD17 CHD7 RIMS1 BCOR TMEM132B DCLK1 ARPC2

2.41e-07963921428671696
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RUFY2 ZBTB34 SSH1 DIS3L CEP135 SLITRK5 KAZN ALPK1 GRIN3A PLCH1

7.64e-07493921015368895
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

EPPK1 DST MYO1D SND1 UBAP2L SUPT6H USP9X DOCK7 ANKRD17 TNKS1BP1 CHD7

1.28e-06653921122586326
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

DST NRXN1 UBAP2L KIAA1549 PLXND1 WDTC1

1.33e-0613092612421765
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RELCH RNMT DST SUPT6H KIAA1549 ANKRD17 TNKS1BP1 PLXND1 INO80 BCOR

1.44e-06529921014621295
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

BICD2 MYO1D SND1 DIS3L UBAP2L SMC6 DOCK7 ANKRD17 INO80 YTHDF3 ARPC2

3.44e-06724921136232890
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

BICD2 SRSF6 SSH1 UBAP2L RBM7 EXO1 ANKRD17 TNKS1BP1 CHD7 RIMS1 BCOR

6.47e-06774921115302935
Pubmed

A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216).

SPTA1 SPTB

6.92e-0629221391962
Pubmed

An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).

SPTA1 SPTB

6.92e-0629222070088
Pubmed

Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin.

SPTA1 SPTB

6.92e-06292215492010
Pubmed

Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.

SPTA1 SPTB

6.92e-0629228102379
Pubmed

Beta-spectrin Promiss-ao: a translation initiation codon mutation of the beta-spectrin gene (ATG --> GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family.

SPTA1 SPTB

6.92e-0629229414314
Pubmed

Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis.

SPTA1 SPTB

6.92e-0629229373273
Pubmed

Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.

SPTA1 SPTB

6.92e-0629229005995
Pubmed

Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis.

SPTA1 SPTB

6.92e-0629227104494
Pubmed

A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.

SPTA1 SPTB

6.92e-0629226215583
Pubmed

Novel mutations in SPTA1 and SPTB identified by whole exome sequencing in eight Thai families with hereditary pyropoikilocytosis presenting with severe fetal and neonatal anaemia.

SPTA1 SPTB

6.92e-06292230198572
Pubmed

Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis.

SPTA1 SPTB

6.92e-0629228844207
Pubmed

Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.

SPTA1 SPTB

6.92e-0629222056132
Pubmed

Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.

SPTA1 SPTB

6.92e-0629222346784
Pubmed

Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis.

SPTA1 SPTB

6.92e-0629223580577
Pubmed

Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.

SPTA1 SPTB

6.92e-0629227883966
Pubmed

Spectrin Cosenza: a novel beta chain variant associated with Sp alphaI/74 hereditary elliptocytosis.

SPTA1 SPTB

6.92e-0629229163587
Pubmed

Retinal Proteomics of a Mouse Model of Dystroglycanopathies Reveals Molecular Alterations in Photoreceptors.

KIAA1549 POMT1

6.92e-06292234027671
Pubmed

Identification of three novel spectrin alpha I/74 mutations in hereditary elliptocytosis: further support for a triple-stranded folding unit model of the spectrin heterodimer contact site.

SPTA1 SPTB

6.92e-0629228018926
Pubmed

Teneurin-3 controls topographic circuit assembly in the hippocampus.

TENM3 ADGRL3

6.92e-06292229414938
Pubmed

Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.

SPTA1 SPTB

6.92e-0629228226774
Pubmed

Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site.

SPTA1 SPTB

6.92e-0629221634521
Pubmed

Erythrocyte spectrin is comprised of many homologous triple helical segments.

SPTA1 SPTB

6.92e-0629226472478
Pubmed

Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.

SPTA1 SPTB

6.92e-06292222164239
Pubmed

Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.

SPTA1 SPTB

6.92e-06292220197550
Pubmed

A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.

SPTA1 SPTB

6.92e-06292217977835
Pubmed

Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers.

ZBTB16 DOCK7 ME1

9.78e-06169235424503
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

PPP1R7 EPPK1 DST SND1 UBAP2L USP9X AMOTL1 DOCK7 MTMR1 ANKRD17 ME1 ARCN1 WDTC1

1.04e-051149921335446349
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

BICD2 DST DOCK7 ANKRD17 TNKS1BP1 CHD7 BCOR ZMYM5

1.57e-0541892834709266
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

BICD2 SRSF6 DIS3L UBAP2L USP9X DOCK7 TNKS1BP1 ALPK1 ARCN1 YTHDF3 ARPC2 WDTC1

1.90e-051038921226673895
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

RUFY2 RELCH SLC26A2 CHP2 DOCK7 KIAA1549 MTMR1 ATP13A3 OCLN

2.05e-0556992930639242
Pubmed

Spectrin's E2/E3 ubiquitin conjugating/ligating activity is diminished in sickle cells.

SPTA1 SPTB

2.07e-05392215929114
Pubmed

Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo.

SPTA1 SPTB

2.07e-0539221385865
Pubmed

SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression.

SND1 SUPT6H

2.07e-05392233305480
Pubmed

Inherited hemolytic disease in mice: a review and update.

SPTA1 SPTB

2.07e-0539226763106
Pubmed

The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding.

SPTA1 SPTB

2.07e-05392220585040
Pubmed

Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia.

SPTA1 SPTB

2.07e-05392229884876
Pubmed

Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences.

NRXN1 RIMS1

2.07e-05392219036990
Pubmed

Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa.

MYO7A RIMS1

2.07e-05392228673385
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PPP1R7 ARHGAP5 RELCH SSH1 MYO1D USP9X CEP135 KIAA1549 MTMR1 BCOR ELP3 ME1

2.10e-051049921227880917
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

BICD2 MYO1D SUPT6H USP9X TNKS1BP1 CHD7 BCOR YTHDF3 TP73

2.65e-0558892938580884
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RNMT DST SRSF6 NRXN1 SUPT6H DOCK7 RBM7 MTMR1 TNKS1BP1 CHD7 INO80 NKAPL

2.85e-051082921238697112
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

EPPK1 DST USP9X AMOTL1 TMEM30A TNKS1BP1 POMT1

2.97e-0533292737433992
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

SSH1 DOCK7 MTMR1 PLCH1 BCOR WDTC1

3.65e-0523292625515538
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

SRSF6 SND1 UBAP2L SUPT6H USP9X AMOTL1 ANKRD17 YTHDF3 TP73

3.76e-0561592931048545
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

MB21D2 DST UBAP2L TNKS1BP1 RIMS1 DCLK1 ADGRL3

3.92e-0534792717114649
Pubmed

Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.

SSH1 ARPC2

4.14e-05492217350576
Pubmed

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.

NRXN1 GRIN3A

4.14e-05492214983056
Pubmed

Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes.

SPTA1 SPTB

4.14e-0549226234993
Pubmed

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

SPTA1 SPTB

4.14e-05492221566095
Pubmed

Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.

SPTA1 SPTB

4.14e-0549223862089
Pubmed

The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes.

SPTA1 SPTB

4.14e-054922379653
Pubmed

Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.

SPTA1 SPTB

4.14e-05492221412925
Pubmed

Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia.

SPTA1 SPTB

4.14e-05492210772878
Pubmed

Clinical manifestation and phenotypic analysis of novel gene mutation in 28 Chinese children with hereditary spherocytosis.

SPTA1 SPTB

4.14e-05492233620149
Pubmed

Expression specificity of the mouse exonuclease 1 (mExo1) gene.

SPTA1 EXO1

4.14e-05492210497278
Pubmed

Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.

SPTA1 SPTB

4.14e-05492212820899
Pubmed

Adducin: structure, function and regulation.

SPTA1 SPTB

4.14e-05492210950304
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PPP1R7 RELCH MB21D2 SRSF6 NRXN1 SND1 MYO7A AMOTL1 SMC6 DOCK7 TNKS1BP1 DCLK1 WDTC1

4.44e-051321921327173435
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

PPP1R7 SRSF6 UBAP2L ANKRD17 BCOR ELP3

4.62e-0524292634011540
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

EPPK1 TENM3 MYO7A SUPT6H TMEM30A CHD7 CCND2

4.78e-0535892732460013
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

SRSF6 SND1 SUPT6H USP9X DOCK7 RBM7 ELP3 CMC2 ARCN1

5.97e-0565392933742100
Pubmed

Major erythrocyte membrane protein genes in EKLF-deficient mice.

SPTA1 SPTB

6.89e-05592216728274
Pubmed

The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.

ZBTB16 KIAA1549

6.89e-05592217118363
Pubmed

TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules.

TMEM132C TMEM132B

6.89e-05592229088312
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

USP9X SPTA1 DCLK1 MYBPC1

7.52e-058492415203218
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

EPPK1 DST SRSF6 MYO1D SND1 UBAP2L SUPT6H USP9X DOCK7 ARCN1 ARPC2

8.34e-051024921124711643
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ZBTB16 DST DOCK7 RBM7 EXO1 ANKRD17 TNKS1BP1 ALPK1 PLCH1 DCLK1

9.49e-05861921036931259
Pubmed

A new intracellular targeting motif in the cytoplasmic tail of the spike protein may act as a target to inhibit SARS-CoV-2 assembly.

SND1 ARCN1 ARPC2

1.01e-043492336572190
Pubmed

Microphthalmia/Anophthalmia/Coloboma Spectrum – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

CHD7 POMT1 BCOR

1.01e-043492320301552
Pubmed

STAT3 down-regulates the expression of cyclin D during liver development.

TDO2 CCND2

1.03e-04692212147685
Pubmed

A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice.

SPTA1 SPTB

1.03e-04692227848995
Pubmed

Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.

EPPK1 OCLN

1.03e-04692225617501
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SND1 UBAP2L USP9X AMOTL1 DOCK7 TNKS1BP1 BCOR ARCN1

1.07e-0454992838280479
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

DST SRSF6 DOCK7 CHD7 DCLK1 ARCN1 YTHDF3

1.11e-0441092726949251
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

EPPK1 DST SRSF6 MYO1D SND1 AMOTL1 BTBD10 DOCK7 ANKRD17 TNKS1BP1 ARCN1 ARPC2

1.19e-041257921236526897
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

ARHGAP5 RNMT UBAP2L SMC6 ANKRD17 CHD7 INO80 BCOR DCLK1 YTHDF3 CCND2

1.38e-041084921111544199
Pubmed

Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man.

SPTA1 SPTB

1.44e-0479223186715
Pubmed

Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning.

MYO7A CHD7

1.44e-04792234004180
Pubmed

Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome.

CHD7 PLXND1

1.44e-04792225985275
Pubmed

An Analysis of Translocations in the Mouse.

MYO7A DOCK7

1.44e-04792217247190
Pubmed

Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.

ARHGAP5 SMC6

1.44e-04792228100790
Pubmed

Myosins: a diverse superfamily.

MYO1D MYO7A

1.44e-04792210722873
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

RUFY2 BICD2 ARHGAP5 DST DIS3L USP9X SPTB DAAM2 DCLK1 ARCN1 ZMYM5 BFSP1

1.46e-041285921235914814
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

PPP1R7 ARHGAP5 DST MYO7A KAZN TUBE1 TMEM132B CCDC39 ARCN1

1.47e-0473692929676528
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TMEM132C EPPK1 TSHZ1 CHD7 ADGRL3 ZMYM5 TP73

1.49e-0443092735044719
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

EPPK1 USP9X SPTA1 AMOTL1 KIAA1549 ELP3 ARPC2

1.49e-0443092732581705
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

DST SLITRK5 CHD7 OCLN ARCN1

1.58e-0419192531177093
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

BICD2 CEP135 ANKRD17 PLXND1

1.60e-041029249734811
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

PPP1R7 SRSF6 USP9X AMOTL1 DOCK7 TSHZ1 BCOR CMC2 YTHDF3 ARPC2

1.66e-04922921027609421
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

RUFY2 RELCH TENM3 ALPK1

1.66e-0410392410819331
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

PPP1R7 ZBTB16 SND1 DIS3L UBAP2L CEP135 ATP13A3 MPHOSPH6 WDTC1

1.76e-0475492933060197
InteractionKCNA3 interactions

EPPK1 MB21D2 DST MYO1D SND1 UBAP2L USP9X DOCK7 SLITRK5 MTMR1 ANKRD17 TNKS1BP1 RIMS1 OCLN PLCH1 ARCN1

1.61e-068719116int:KCNA3
InteractionDIS3L interactions

BICD2 DIS3L RBM7 MPHOSPH6 WDTC1

3.03e-0650915int:DIS3L
InteractionKCTD13 interactions

PPP1R7 ARHGAP5 DST MYO1D SND1 MYO7A UBAP2L USP9X SPTA1 SPTB DOCK7 KIAA1549 MTMR1 TNKS1BP1 RIMS1 PLCH1 ELP3 DCLK1 ARCN1 ARPC2

3.13e-0613949120int:KCTD13
InteractionEXOSC5 interactions

DIS3L SPTA1 RBM7 DAAM2 MPHOSPH6 YTHDF3 WDTC1

9.48e-06164917int:EXOSC5
InteractionUNK interactions

ARHGAP5 DST SND1 UBAP2L USP9X ANKRD17 TMEM30A TNKS1BP1 YTHDF3 ARPC2

1.55e-054089110int:UNK
InteractionAFDN interactions

BICD2 DST NRXN1 ZNF382 USP9X AMOTL1 OCLN PLCH1 DCLK1

1.97e-05333919int:AFDN
InteractionMEX3A interactions

EPPK1 DST UBAP2L USP9X AMOTL1 TMEM30A TNKS1BP1 POMT1 YTHDF3

5.96e-05384919int:MEX3A
InteractionMKRN2 interactions

TENM3 MYO7A UBAP2L TMEM30A CHD7 BCOR YTHDF3 CCND2 WDTC1

6.09e-05385919int:MKRN2
InteractionGJA1 interactions

MB21D2 DST MYO1D SND1 USP9X KIAA1549 ATP13A3 OCLN PLCH1 ARCN1 WDTC1

6.30e-055839111int:GJA1
GeneFamilyEF-hand domain containing|Spectrins

SPTA1 SPTB

2.18e-0475921113
GeneFamilyEF-hand domain containing|Plakins

EPPK1 DST

2.89e-048592939
GeneFamilyDNA helicases

CHD7 INO80

1.38e-03175921167
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TMEM132C PPP1R7 MYO1D OCLN

2.88e-03181594694
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

DST NRXN1 TENM3 SLITRK5 DAAM2 TMEM132B ADGRL3

5.99e-0816892788c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMEM132C TENM3 AMOTL1 KAZN GRIN3A PLCH1 ANKRD55

1.54e-071939274979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN1 TENM3 SLITRK5 DAAM2 TMEM132B ADGRL3

1.10e-06162926d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN1 TENM3 SLITRK5 DAAM2 TMEM132B ADGRL3

1.10e-061629265bbd7130d4dad9035e73a439dda568195c136f31
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN1 TENM3 SLITRK5 DAAM2 TMEM132B ADGRL3

1.10e-06162926eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN1 TENM3 SLITRK5 DAAM2 TMEM132B ADGRL3

1.10e-06162926e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

NRXN1 TENM3 SLITRK5 DAAM2 TMEM132B ADGRL3

1.22e-061659266ed52cb756d21addf46c7f6c457458b01339fe04
ToppCell10x3'2.3-week_17-19-Neuro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MB21D2 NRXN1 TENM3 CHP2 TMEM132B ADGRL3

1.72e-06175926bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell10x3'2.3-week_17-19-Neuro-stroma-schwann_cells|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MB21D2 NRXN1 TENM3 CHP2 TMEM132B ADGRL3

1.72e-061759268b010220cdfb680ec839572f4933adfb85045ea6
ToppCell10x3'2.3-week_17-19-Neuro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MB21D2 NRXN1 TENM3 CHP2 TMEM132B ADGRL3

1.72e-061759260b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCellRA-16._Neuronal|RA / Chamber and Cluster_Paper

NRXN1 TENM3 SLITRK5 DAAM2 TMEM132B ADGRL3

2.02e-061809265842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN1 CYP7A1 SPTA1 PLCH1 SPAG17 ADGRL3

2.30e-061849262cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN1 CYP7A1 SPTA1 PLCH1 SPAG17 ADGRL3

2.30e-06184926ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN1 CYP7A1 SPTA1 PLCH1 SPAG17 ADGRL3

2.30e-061849262b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMEM132C TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

3.03e-0619392653bcd50892c379b2a571751f6eb1062436339fe7
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMEM132C TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

3.12e-06194926e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN1 KAZN RIMS1 TMEM132B ELMOD1 DCLK1

3.51e-061989264ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

3.71e-0620092645ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCellControl-Fibroblasts-Mesothelial_FB|Control / group, cell type (main and fine annotations)

TMEM132C NRXN1 TENM3 ANKRD55 DCLK1

1.04e-05139925e769beb031b262dd92c9605b07dbf3c29fb82520
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM132C ZBTB16 MYO1D DAAM2 GRIN3A

2.30e-05164925f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTX4 NRAP PLCH1 TP73 MYBPC1

2.51e-05167925d78356bf0c473816dbabaee51984940bd822f84e
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

NRXN1 TENM3 CHP2 TMEM132B ADGRL3

2.59e-051689252fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DST NRXN1 TENM3 CHD7 TMEM132B

2.59e-05168925af82e07d1eec51fc6530155f37addbce6221885d
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

NRXN1 TENM3 CHP2 TMEM132B ADGRL3

2.59e-05168925c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellLV-16._Neuronal|LV / Chamber and Cluster_Paper

NRXN1 TENM3 SLITRK5 TMEM132B ADGRL3

2.66e-05169925a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCellfacs-Marrow-T_cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 IRF4 ANKRD55 TP73 CCND2

2.98e-05173925e0cf99ddbe6e9eab05d7bf89e9aa124850c6a807
ToppCellRA-16._Neuronal|World / Chamber and Cluster_Paper

NRXN1 TENM3 SLITRK5 TMEM132B ADGRL3

3.69e-051819257d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DST NRXN1 TENM3 CHD7 TMEM132B

3.69e-05181925a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCellCOVID-19-B_cells-Plasma_cells|COVID-19 / group, cell type (main and fine annotations)

MYO1D SND1 IRF4 TP73 CCND2

3.89e-05183925130c109f63a5e3c8f83cb96e32f4addf513b6415
ToppCellCOVID-19-B_cells|COVID-19 / group, cell type (main and fine annotations)

MYO1D SND1 IRF4 TP73 CCND2

3.89e-051839252c016bb59f131a0e821853b085289a3583f0a729
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TMEM132C DAAM2 TSHZ1 RIMS1 TMEM132B

3.89e-0518392512daaea821e49bc94a01e2496331e92a80d27339
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

TMEM132C ZBTB16 KAZN CCDC39 DCLK1

3.99e-051849252b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMEM132C TENM3 GRIN3A PLCH1 ANKRD55

3.99e-0518492523515c28e1f42aab29cef9e5b4a7f45bda7f5520
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.31e-0518792504dba2ed09ee4180830bdf0191921696697ea234
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.31e-051879251bba994aaaa9825b54aaeaff3829850267bc4602
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM132C MYO1D KIAA1549 DAAM2 GRIN3A

4.31e-0518792515d6e158562d7d85af3ceaf955439b379c8fce81
ToppCellfacs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.31e-05187925805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM132C MYO1D KIAA1549 DAAM2 GRIN3A

4.31e-05187925f62074b631fd45ad299c69d71b09267b04d656ee
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.31e-05187925d6ac351e7aeba98851d308c14ac395044fe4fbbb
ToppCelldroplet-Lung-1m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.42e-05188925bc0b9ba8ae88e8a89e98b446584ed39606e4229e
ToppCelldroplet-Lung-1m-Epithelial-airway_epithelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.42e-0518892550994e304c719f2f3c3232e48141e2dd15c96612
ToppCelldroplet-Lung-1m-Epithelial-airway_epithelial-lung_ciliated_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.42e-05188925a7b7ba56603a8a50869b41902aed6a9ab1c5c021
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.54e-0518992528c750ac56e3861fe7280e32839a4d8ce8bd8692
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.54e-05189925efee01edd171bf569267b672fab05c421de6c92d
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.54e-05189925a28e0922e10013ae79266f6a3f9305e6ee614d8b
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLCH1 SPAG17 ELMOD1 CCDC39 TP73

4.65e-051909259ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMEM132C TENM3 GRIN3A PLCH1 ANKRD55

4.65e-05190925d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLCH1 SPAG17 ELMOD1 CCDC39 TP73

4.65e-051909253ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO1D TENM3 DAAM2 DCLK1 ADGRL3

4.65e-0519092570c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.65e-05190925edc0a0eb17abbecb0f06d302be3d4f8c1dd4f333
ToppCellfacs-Pancreas-Endocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DST SND1 USP9X TMEM30A CCND2

4.77e-05191925b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCellRV-01._Fibroblast_I|World / Chamber and Cluster_Paper

TMEM132C ZBTB16 KAZN DCLK1 ADGRL3

4.77e-0519192570c067c54084bfb02c29bab085f4defd477194fb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TMEM132C TENM3 AMOTL1 GRIN3A PLCH1

4.77e-05191925782bc7946417549ffd39e5b596db659436fa01ba
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPPK1 SPAG17 ELMOD1 CCDC39 TP73

4.77e-051919256a8fc9dc1a4c7115862e8f20204fa2f95e50e22f
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYO1D EXO1 IRF4 TP73 CCND2

4.77e-05191925b23fdcd3090df9f58310b4dc8f7dc0c6d6b33226
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLITRK5 EXO1 MYH16 CHD7 TP73

4.89e-05192925d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

5.01e-05193925d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

5.01e-051939252189da4b727e25e62669d7b9257f06493be21a27
ToppCellControl-Myeloid-cDC2|Myeloid / Disease state, Lineage and Cell class

ARHGAP5 MB21D2 MYO1D IRF4 CCND2

5.01e-051939254cb938c346cc32ec122d11e6b9f25db20e0f7ff6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

5.01e-051939253ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

5.01e-05193925e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

5.01e-05193925658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM132C ZBTB16 KAZN CCDC39 DCLK1

5.01e-05193925261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

5.14e-0519492583863da11dfbe59b2d0a2c08db40b537c150588c
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

MB21D2 TENM3 IRF4 TDO2 DCLK1

5.14e-05194925eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 KAZN GRIN3A ANKRD55

5.14e-051949254f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 KAZN GRIN3A ANKRD55

5.14e-0519492502a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM132C ZBTB16 MB21D2 KAZN DCLK1

5.26e-05195925ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

ZBTB16 DST TENM3 KAZN ADGRL3

5.26e-05195925603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 AMOTL1 KAZN GRIN3A ANKRD55

5.39e-051969257af6c5147ac859353504d19727dbe24f63a29dd4
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB16 SND1 USP9X TMEM30A ARCN1

5.39e-05196925151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZBTB16 DST USP9X TMEM30A ARCN1

5.52e-05197925e77016d64b1cac9825fec7cfe5071f1567401187
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB16 DST USP9X TMEM30A ARCN1

5.52e-051979250353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DST NRXN1 TENM3 TMEM132B ADGRL3

5.52e-05197925b2f4d7c301c0b24003374923b31d6d058e40b213
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TMEM132C ZBTB16 DST KAZN TDO2

5.52e-051979250034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TMEM132C DST TSHZ1 KAZN TDO2

5.52e-0519792511a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellfacs-Tongue-nan-3m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP5 EPPK1 DST USP9X ARCN1

5.66e-051989252f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN1 RIMS1 TMEM132B ELMOD1 DCLK1

5.66e-05198925c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DST NRXN1 TENM3 CHD7 TMEM132B

5.66e-0519892550dfe6efca76ea9683a19b6bff59cb5030d346f1
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DST NRXN1 TENM3 CHD7 TMEM132B

5.66e-051989255b9a7b9f53a3d9cf8d6e6a7c1c94514b22cf9fa8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN1 RIMS1 TMEM132B ELMOD1 DCLK1

5.66e-051989256d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

MYO7A PLCH1 SPAG17 CCDC39 TP73

5.66e-051989256d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellfacs-Tongue-nan-3m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP5 EPPK1 DST USP9X ARCN1

5.66e-05198925f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMEM132C DST TENM3 KAZN DCLK1

5.66e-0519892521cf4d81386761d09d0f6829c01c198e5524176d
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP5 EPPK1 DST USP9X ARCN1

5.79e-051999258d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCellMesenchymal|World / Lineage, Cell type, age group and donor

TMEM132C DST TENM3 KAZN DCLK1

5.79e-051999254bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TMEM132C DST SLITRK5 TDO2 ALPK1

5.93e-052009259b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C KAZN GRIN3A PLCH1 ANKRD55

5.93e-05200925f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C TENM3 AMOTL1 GRIN3A PLCH1

5.93e-052009255ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C KAZN GRIN3A PLCH1 ANKRD55

5.93e-0520092570a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C TENM3 AMOTL1 GRIN3A PLCH1

5.93e-05200925e79d93d55b25804f2608185168da472301b6ebca
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

NRXN1 SLITRK5 ELMOD1 DCLK1 ARPC2

5.93e-05200925db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM3 AMOTL1 GRIN3A PLCH1 ANKRD55

5.93e-05200925347a510755374c6a66acee326565dfc447993f18
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

NRXN1 SLITRK5 ELMOD1 DCLK1 ARPC2

5.93e-0520092530a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C TENM3 GRIN3A PLCH1 ANKRD55

5.93e-05200925107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C KAZN GRIN3A PLCH1 ANKRD55

5.93e-052009251639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C TENM3 AMOTL1 GRIN3A PLCH1

5.93e-05200925320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Necab1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TMEM132C SPTB GRIN3A TUBE1

1.35e-04126924a4fc7ac4931d2fc8aa8196a62d809b698937aa9c
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

NRXN1 EXO1 TMEM132B ADGRL3

2.51e-041489240dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|356C / Donor, Lineage, Cell class and subclass (all cells)

ZBTB16 SPTA1 SPTB KIAA1549

2.64e-041509246bdf9df586f348641a25a445e83a41e47e7f347e
Diseasenon-high density lipoprotein cholesterol measurement

INTS10 SSH1 CYP7A1 SPTA1 SMC6 DOCK7 CHD7 MMP26 M6PR ARCN1 CCND2

1.00e-057138911EFO_0005689
DiseaseHereditary elliptocytosis

SPTA1 SPTB

5.38e-054892cv:C0013902
Diseasemean platelet volume

ZBTB16 SRSF6 SSH1 DIS3L SPTA1 DOCK7 MTMR1 CHD7 ATP13A3 PLXND1 BCOR ARPC2

5.60e-0510208912EFO_0004584
DiseaseAnemia, hereditary spherocytic hemolytic

SPTA1 SPTB

8.94e-055892C0221409
Diseasehereditary spherocytosis (is_implicated_in)

SPTA1 SPTB

8.94e-055892DOID:12971 (is_implicated_in)
DiseaseHereditary spherocytosis

SPTA1 SPTB

8.94e-055892cv:C0037889
Diseaseproliferative diabetic retinopathy (is_implicated_in)

SRSF6 BCOR

1.34e-046892DOID:13207 (is_implicated_in)
DiseaseElliptocytosis, Hereditary

SPTA1 SPTB

1.34e-046892C0013902
DiseaseHereditary spherocytosis

SPTA1 SPTB

2.49e-048892C0037889
Diseaseprogression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma

INTS10 ZBTB34 DCLK1

2.80e-0442893EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

INTS10 CYP7A1 DOCK7 CCND2

3.62e-04111894EFO_0004530, EFO_0008595
Diseasestomach carcinoma (is_implicated_in)

BCOR CCND2

5.82e-0412892DOID:5517 (is_implicated_in)
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

ZBTB16 RNMT NRAP NRXN1 SND1 UBAP2L CHD7 TMEM132B ADGRL3

7.01e-04801899EFO_0003888, EFO_0007052, MONDO_0002491
DiseaseAutistic Disorder

MYO1D NRXN1 SND1 RIMS1 TDO2

1.18e-03261895C0004352
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

INTS10 CYP7A1 DOCK7 CCND2

1.63e-03166894EFO_0004530, EFO_0004611
Diseasesevere acute respiratory syndrome, COVID-19

TMEM132C NRXN1 MYO7A USP9X ADGRL3 ARPC2

2.36e-03447896EFO_0000694, MONDO_0100096
Diseaselung squamous cell carcinoma (is_implicated_in)

TP73 CCND2

2.38e-0324892DOID:3907 (is_implicated_in)
Diseaserheumatoid arthritis

ZBTB34 PTX4 MB21D2 IRF4 ALPK1 ANKRD55

2.77e-03462896EFO_0000685
DiseaseS-warfarin to R-warfarin ratio measurement

MMP26 ELMOD1 ADGRL3

3.01e-0395893EFO_0803331
Diseasecolorectal adenocarcinoma (is_marker_for)

TP73 ARPC2

3.01e-0327892DOID:0050861 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
REHNFTRPNEKGEYE

BTBD10

201

Q9BSF8
KLRREAYDSDNPQHE

ELMOD1

121

Q8N336
EAREAQHAEEKGRYE

BICD2

461

Q8TD16
ENPTEENRHRISKYS

ATP13A3

116

Q9H7F0
KEGENRAVIHYRDDE

ARPC2

136

O15144
IIDRGYNHNETALEK

ADGRL3

1221

Q9HAR2
NRQLSSREYEGHEDK

AMOTL1

526

Q8IY63
EEQRAHQKDPSRDRY

ANKRD55

356

Q3KP44
ARGANKEHRNVSDYT

ANKRD17

1171

O75179
ESERCEYSVGNKHRD

BCOR

1076

Q6W2J9
SHGRYKRQLTEQDVE

CHD7

1626

Q9P2D1
EEVNYHVDDRSARKE

ALPK1

596

Q96QP1
AYQDHETSRIQLKGE

CCDC39

296

Q9UFE4
SADDIQRIQHLYGEK

MMP26

241

Q9NRE1
SENVSRDYKALRDGN

MTMR1

76

Q13613
RAGRSKRTEQDHYET

OCLN

386

Q16625
EGESHQRYLRNKDFL

INO80

936

Q9ULG1
VSNVYGDVEIDRNKH

INTS10

351

Q9NVR2
DDLSSGDTKERHRVY

KIAA1549

1551

Q9HCM3
YRQDQRDGSKSEDEL

CCND2

261

P30279
RYSDDGNRETDEKVA

RELCH

191

Q9P260
AYQRHQKELGSTEDI

DAAM2

646

Q86T65
RNRDEGSYHVDESRN

NRXN1

421

P58400
FIRNYEQHRKESEDA

KAZN

176

Q674X7
AQQVSDKHLEEGRLY

ME1

486

P48163
QEFTKHDQREYDDQR

MB21D2

41

Q8IYB1
HAGKQDYNREEDAAL

IRF4

56

Q15306
QLASQVEYKRGHDER

NRAP

186

Q86VF7
GRYEDLSKSVNERNE

DST

4136

Q03001
HFDERDKAQRYSRGS

DCLK1

11

O15075
KEQDSLGLQSHEYRV

PLXND1

1201

Q9Y4D7
YSQHAVKQLEGEARD

GOLGA6L6

136

A8MZA4
RERIEENGHNTYASQ

FGF22

116

Q9HCT0
RNRDEGSYHVDESRN

NRXN1

1426

Q9ULB1
HDNRRKYIFSDEEGQ

GRIN3A

1021

Q8TCU5
EARRYQGEHKDDAPT

RIMS1

101

Q86UR5
EEHRYGASQEQRERE

POMT1

511

Q9Y6A1
DRKADEDHYREQQAL

TP73

301

O15350
KGDYNSEIHQITRER

CEP135

491

Q66GS9
DDYQHRLSIKRGELE

CEP135

681

Q66GS9
GNSYQDDQDDLKRRS

DOCK7

166

Q96N67
EYVENRTKSREHGIA

CMC2

51

Q9NRP2
REERSQQAYKSQHGE

GALT

201

P07902
RERENESQESHGKEY

DIS3L

211

Q8TF46
RKEQYEHADEASRAA

BFSP1

11

Q12934
HRRYVKSRDDSQLNG

TMEM30A

131

Q9NV96
YEDVARDTNRGHTVK

ELP3

251

Q9H9T3
AHYNELQEVGLEKRS

RNMT

151

O43148
TLHLEDGSYNIRKDD

CYP7A1

371

P22680
RDAEDVDLNHYRIGK

PPP1R7

76

Q15435
SDDKYGRIRLHVENE

ARCN1

306

P48444
YATEDNDNKLVLHGR

PTX4

316

Q96A99
RDGLFDTIQRSKNHY

USP9X

2366

Q93008
SHDYDNRRDSSRDGK

RBM7

246

Q9Y580
ETELQTYKHSRQGLD

RUFY2

281

Q8WXA3
NDIEGINREYKDHLS

TMEM132B

801

Q14DG7
DYEEDEIKNHASDRR

TMEM132C

811

Q8N3T6
NRRHYRDNFKGEENE

TDO2

176

P48775
RKRDHANYEEDENGD

MPHOSPH6

131

Q99547
DLYERLEHGQATAKD

EPPK1

581

P58107
ELRSRDGSEYLIQHD

ARHGAP27

581

Q6ZUM4
RQDDDQRSSHYDELL

SND1

466

Q7KZF4
ITEADSKEVYGRHQR

ARHGAP5

466

Q13017
RQAGEVTYADAHKER

SRSF6

131

Q13247
HYGLSDENNDDRVLK

SWT1

476

Q5T5J6
NLHESEYGDQEGKRL

EXO1

536

Q9UQ84
TQLKRRGEDDHTNRY

SPAG17

196

Q6Q759
SEYEGILDASKQRHN

SSH1

441

Q8WYL5
QLYDLDRDGKISRHE

CHP2

121

O43745
QSAEDYEKEESHRQR

NKAPL

106

Q5M9Q1
DITATGQKLRNRYHE

TEPP

151

Q6URK8
FGENLRDSYQRHETE

SUPT6H

546

Q7KZ85
DGLIRQYDLRENSKH

WDTC1

156

Q8N5D0
TEHGNKRLDAAYRSL

YTHDF3

441

Q7Z739
SARELHYGREESAEQ

ZBTB16

291

Q05516
SNEEGKENRDRDRDY

UBAP2L

116

Q14157
DEYDNHCGKEQRRAV

M6PR

126

P20645
ENRSHKVRYSDSVEN

SPO16

31

Q5VVC0
RSREGNSVEDYKDLH

SLITRK5

766

O94991
VDRELQKAGYDNAHS

SLC26A2

176

P50443
REHAAVNQKGIYDEA

TUBE1

26

Q9UJT0
KRDHHGRYSSQDADE

TNKS1BP1

911

Q9C0C2
SEVDNQKRGKRHYEE

SMC6

806

Q96SB8
DHDSSRLLYGNRVKD

TENM3

51

Q9P273
ESGHPRSREVKQYQD

SPTB

916

P11277
IKDEIDGHQDSYQRV

SPTB

1106

P11277
RVAERGQKLEDSYHL

SPTA1

41

P02549
DHYDSENIKAIRDGL

SPTA1

546

P02549
SENNSHYVRKRSIGD

PLCH1

901

Q4KWH8
DEDARQHEELRKQYN

MYH16

821

Q9H6N6
AEHRLYENEKNDGVL

ZMYM5

651

Q9UJ78
TRAHRGERTFEYNKD

ZNF382

231

Q96SR6
NETGHYRDDNRDKDS

TSHZ1

266

Q6ZSZ6
EYQADGRQDRKSNLH

ZNF300

81

Q96RE9
RKDQLEYHIRGHTDD

ZBTB34

411

Q8NCN2
IIDKQHTEQEASYGR

MYO1D

326

O94832
RNDNSSRFGKYIDIH

MYO7A

206

Q13402
RDDSGVYHINLKNEA

MYBPC1

591

Q00872