Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	6.63e-05	4	67	2	GO:0047718
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	6.63e-05	4	67	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	6.63e-05	4	67	2	GO:0045703
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	6.63e-05	4	67	2	GO:0047743
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	1.10e-04	5	67	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.10e-04	5	67	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	1.10e-04	5	67	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	1.10e-04	5	67	2	GO:0047006
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	1.10e-04	5	67	2	GO:0047787
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	1.10e-04	5	67	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	1.10e-04	5	67	2	GO:0047086
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C2	1.65e-04	6	67	2	GO:0045550
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	2.30e-04	7	67	2	GO:0072582
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C2	3.07e-04	8	67	2	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C1 AKR1C2	3.07e-04	8	67	2	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C2	3.07e-04	8	67	2	GO:0035671
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C2	3.93e-04	9	67	2	GO:0047044
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C2	3.93e-04	9	67	2	GO:0070401
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	4.91e-04	10	67	2	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C1 AKR1C2	4.91e-04	10	67	2	GO:0032052
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1C1 AKR1C2	9.83e-04	14	67	2	GO:0001758
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1C1 AKR1C2	9.83e-04	14	67	2	GO:0004032
GeneOntologyMolecularFunction	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	AKR1C1 AKR1C2	2.03e-03	20	67	2	GO:0004303
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	AKR1C1 AKR1C2	2.92e-03	24	67	2	GO:0004745
GeneOntologyMolecularFunction	RNA polymerase II core promoter sequence-specific DNA binding	GBX2 RFX7	3.17e-03	25	67	2	GO:0000979
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	AKR1C1 AKR1C2	3.42e-03	26	67	2	GO:0004022
GeneOntologyMolecularFunction	NADPH binding	AKR1C1 AKR1C2	3.42e-03	26	67	2	GO:0070402
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	3.69e-03	27	67	2	GO:0008106
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	AKR1C1 AKR1C2	4.54e-03	30	67	2	GO:0018455
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	AKR1C1 AKR1C2	5.16e-03	32	67	2	GO:0004033
GeneOntologyMolecularFunction	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	AKR1C1 AKR1C2	5.48e-03	33	67	2	GO:0033764
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	AKR1C1 AKR1C2	5.81e-03	34	67	2	GO:0016628
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	UBE2U BIRC6	6.85e-03	37	67	2	GO:0061631
GeneOntologyMolecularFunction	steroid dehydrogenase activity	AKR1C1 AKR1C2	7.59e-03	39	67	2	GO:0016229
GeneOntologyBiologicalProcess	response to jasmonic acid	AKR1C1 AKR1C2	6.03e-05	4	66	2	GO:0009753
GeneOntologyBiologicalProcess	progesterone catabolic process	AKR1C1 AKR1C2	6.03e-05	4	66	2	GO:0006709
GeneOntologyBiologicalProcess	cellular response to jasmonic acid stimulus	AKR1C1 AKR1C2	6.03e-05	4	66	2	GO:0071395
GeneOntologyBiologicalProcess	C21-steroid hormone catabolic process	AKR1C1 AKR1C2	6.03e-05	4	66	2	GO:0008208
GeneOntologyBiologicalProcess	farnesol metabolic process	AKR1C1 AKR1C2	1.00e-04	5	66	2	GO:0016487
GeneOntologyBiologicalProcess	farnesol catabolic process	AKR1C1 AKR1C2	1.00e-04	5	66	2	GO:0016488
GeneOntologyBiologicalProcess	negative regulation of isoprenoid metabolic process	AKR1C1 AKR1C2	1.00e-04	5	66	2	GO:0045827
GeneOntologyBiologicalProcess	sesquiterpenoid catabolic process	AKR1C1 AKR1C2	1.00e-04	5	66	2	GO:0016107
GeneOntologyBiologicalProcess	olefinic compound catabolic process	AKR1C1 AKR1C2	1.00e-04	5	66	2	GO:0120256
GeneOntologyBiologicalProcess	negative regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	1.00e-04	5	66	2	GO:1900053
GeneOntologyBiologicalProcess	sesquiterpenoid metabolic process	AKR1C1 AKR1C2	1.50e-04	6	66	2	GO:0006714
GeneOntologyBiologicalProcess	polyprenol catabolic process	AKR1C1 AKR1C2	1.50e-04	6	66	2	GO:0016095
GeneOntologyBiologicalProcess	response to prostaglandin D	AKR1C1 AKR1C2	2.10e-04	7	66	2	GO:0071798
GeneOntologyBiologicalProcess	cellular response to prostaglandin D stimulus	AKR1C1 AKR1C2	2.10e-04	7	66	2	GO:0071799
GeneOntologyBiologicalProcess	regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	2.10e-04	7	66	2	GO:1900052
GeneOntologyBiologicalProcess	cellular response to fatty acid	CPS1 AKR1C1 AKR1C2	3.29e-04	42	66	3	GO:0071398
GeneOntologyBiologicalProcess	daunorubicin metabolic process	AKR1C1 AKR1C2	3.58e-04	9	66	2	GO:0044597
GeneOntologyBiologicalProcess	establishment of planar polarity	PKHD1 DLG3 CPLANE1	3.77e-04	44	66	3	GO:0001736
GeneOntologyBiologicalProcess	establishment of tissue polarity	PKHD1 DLG3 CPLANE1	4.03e-04	45	66	3	GO:0007164
GeneOntologyBiologicalProcess	doxorubicin metabolic process	AKR1C1 AKR1C2	4.46e-04	10	66	2	GO:0044598
GeneOntologyBiologicalProcess	regulation of isoprenoid metabolic process	AKR1C1 AKR1C2	4.46e-04	10	66	2	GO:0019747
GeneOntologyBiologicalProcess	negative regulation of vitamin metabolic process	AKR1C1 AKR1C2	4.46e-04	10	66	2	GO:0046137
GeneOntologyBiologicalProcess	polyketide metabolic process	AKR1C1 AKR1C2	4.46e-04	10	66	2	GO:0030638
GeneOntologyBiologicalProcess	aminoglycoside antibiotic metabolic process	AKR1C1 AKR1C2	4.46e-04	10	66	2	GO:0030647
GeneOntologyBiologicalProcess	regulation of testosterone biosynthetic process	AKR1C1 AKR1C2	5.44e-04	11	66	2	GO:2000224
GeneOntologyBiologicalProcess	terpenoid catabolic process	AKR1C1 AKR1C2	5.44e-04	11	66	2	GO:0016115
GeneOntologyBiologicalProcess	regulation of cell-cell adhesion involved in gastrulation	MBP MAP2K5	6.52e-04	12	66	2	GO:0070587
GeneOntologyBiologicalProcess	negative regulation of heterotypic cell-cell adhesion	MBP MAP2K5	6.52e-04	12	66	2	GO:0034115
GeneOntologyBiologicalProcess	cell-cell adhesion involved in gastrulation	MBP MAP2K5	7.69e-04	13	66	2	GO:0070586
MousePheno	abnormal myelination	PTPRZ1 FA2H MBP LAMA4 AKR1C1 AKR1C2	1.42e-05	166	45	6	MP:0000920
MousePheno	abnormal oligodendrocyte morphology	PTPRZ1 MBP AKR1C1 AKR1C2	2.10e-05	51	45	4	MP:0000953
MousePheno	abnormal spatial learning	ANK2 PTPRZ1 FA2H MBP SUPT16H DLG3 DNMT1	2.59e-05	276	45	7	MP:0001463
Domain	ALDOKETO_REDUCTASE_1	AKR1C1 AKR1C2	5.27e-04	10	65	2	PS00798
Domain	Aldo/ket_reductase_CS	AKR1C1 AKR1C2	5.27e-04	10	65	2	IPR018170
Domain	Aldo/keto_reductase	AKR1C1 AKR1C2	5.27e-04	10	65	2	IPR020471
Domain	ALDOKETO_REDUCTASE_2	AKR1C1 AKR1C2	5.27e-04	10	65	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1C1 AKR1C2	5.27e-04	10	65	2	PS00063
Domain	-	STAB2 HMCN1	6.43e-04	11	65	2	2.40.155.10
Domain	GFP-like	STAB2 HMCN1	6.43e-04	11	65	2	IPR023413
Domain	DUF4599	SPATA31D4 SPATA31D3	7.70e-04	12	65	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	7.70e-04	12	65	2	IPR027970
Domain	PB1	PARD6B MAP2K5	1.06e-03	14	65	2	SM00666
Domain	PB1	PARD6B MAP2K5	1.06e-03	14	65	2	PF00564
Domain	PB1	PARD6B MAP2K5	1.06e-03	14	65	2	PS51745
Domain	PB1_dom	PARD6B MAP2K5	1.06e-03	14	65	2	IPR000270
Domain	-	AKR1C1 AKR1C2	1.39e-03	16	65	2	3.20.20.100
Domain	NADP_OxRdtase_dom	AKR1C1 AKR1C2	1.57e-03	17	65	2	IPR023210
Domain	Aldo_ket_red	AKR1C1 AKR1C2	1.57e-03	17	65	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1C1 AKR1C2	1.57e-03	17	65	2	IPR001395
Domain	DEATH	ANK2 DAPK1	3.96e-03	27	65	2	SM00005
Domain	EGF_LAM_2	STAB2 LAMA4	4.87e-03	30	65	2	PS50027
Domain	EGF_LAM_1	STAB2 LAMA4	4.87e-03	30	65	2	PS01248
Domain	Ig_E-set	PKHD1 TGM6 NXPE3	5.70e-03	104	65	3	IPR014756
Domain	Death	ANK2 DAPK1	5.87e-03	33	65	2	PF00531
Domain	EGF_Lam	STAB2 LAMA4	6.59e-03	35	65	2	SM00180
Pubmed	Placental endocrine function shapes cerebellar development and social behavior.	MBP AKR1C1 AKR1C2	2.45e-06	14	67	3	34400844
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	3.66e-06	2	67	2	8573067
Pubmed	Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.	AKR1C1 AKR1C2	3.66e-06	2	67	2	11514561
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	3.66e-06	2	67	2	15492289
Pubmed	Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.	HEATR5A HEATR5B	3.66e-06	2	67	2	38240799
Pubmed	cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.	AKR1C1 AKR1C2	3.66e-06	2	67	2	8011662
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	3.66e-06	2	67	2	18654764
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	3.66e-06	2	67	2	21217827
Pubmed	The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.	AKR1C1 AKR1C2	3.66e-06	2	67	2	26934124
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	3.66e-06	2	67	2	8486699
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2	1.10e-05	3	67	2	19320734
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2	1.10e-05	3	67	2	31780644
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2	1.10e-05	3	67	2	21232532
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2	1.10e-05	3	67	2	13678667
Pubmed	Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.	AKR1C1 AKR1C2	1.10e-05	3	67	2	22064385
Pubmed	Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.	DAPK1 DNMT1	1.10e-05	3	67	2	27286455
Pubmed	Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation.	ANK2 FA2H MBP	1.52e-05	25	67	3	32266943
Pubmed	Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.	PTPRZ1 MBP LAMA4	1.52e-05	25	67	3	19373938
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C1 AKR1C2	2.19e-05	4	67	2	20124700
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C1 AKR1C2	2.19e-05	4	67	2	10500239
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C1 AKR1C2	2.19e-05	4	67	2	16508162
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C1 AKR1C2	2.19e-05	4	67	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	2.19e-05	4	67	2	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C1 AKR1C2	2.19e-05	4	67	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C1 AKR1C2	2.19e-05	4	67	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C1 AKR1C2	2.19e-05	4	67	2	31479646
Pubmed	KLF4, DAPK1 and SPG20 promoter methylation is not affected by DNMT1 silencing and hypomethylating drugs in lymphoma cells.	DAPK1 DNMT1	2.19e-05	4	67	2	34751409
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	2.19e-05	4	67	2	15222881
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C1 AKR1C2	2.19e-05	4	67	2	16191478
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C1 AKR1C2	2.19e-05	4	67	2	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C1 AKR1C2	2.19e-05	4	67	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C1 AKR1C2	2.19e-05	4	67	2	17034817
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C1 AKR1C2	2.19e-05	4	67	2	17629694
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C1 AKR1C2	2.19e-05	4	67	2	29764944
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C1 AKR1C2	2.19e-05	4	67	2	10526179
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C1 AKR1C2	2.19e-05	4	67	2	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C1 AKR1C2	2.19e-05	4	67	2	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C1 AKR1C2	2.19e-05	4	67	2	28329705
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C1 AKR1C2	2.19e-05	4	67	2	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	2.19e-05	4	67	2	17272929
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C1 AKR1C2	2.19e-05	4	67	2	19237748
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C1 AKR1C2	2.19e-05	4	67	2	18667791
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C1 AKR1C2	2.19e-05	4	67	2	28259989
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C1 AKR1C2	2.19e-05	4	67	2	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	2.19e-05	4	67	2	8274401
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	2.19e-05	4	67	2	16511129
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C1 AKR1C2	2.19e-05	4	67	2	10803568
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C1 AKR1C2	2.19e-05	4	67	2	34590152
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C1 AKR1C2	2.19e-05	4	67	2	7789999
Pubmed	Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.	AKR1C1 AKR1C2	3.64e-05	5	67	2	7737980
Pubmed	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.	AKR1C1 AKR1C2	3.64e-05	5	67	2	21851338
Pubmed	Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.	AKR1C1 AKR1C2	3.64e-05	5	67	2	17872381
Pubmed	Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia.	MBP PLD2	3.64e-05	5	67	2	21085684
Pubmed	Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.	AKR1C1 AKR1C2	3.64e-05	5	67	2	17064890
Pubmed	Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth.	ZDBF2 DNMT1	3.64e-05	5	67	2	27841881
Pubmed	Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.	AKR1C1 AKR1C2	3.64e-05	5	67	2	10672042
Pubmed	PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals.	RPTOR PLD2	3.64e-05	5	67	2	16837165
Pubmed	Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.	AKR1C1 AKR1C2	3.64e-05	5	67	2	38788959
Pubmed	Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.	AKR1C1 AKR1C2	3.64e-05	5	67	2	15212687
Pubmed	Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.	AKR1C1 AKR1C2	3.64e-05	5	67	2	16984997
Pubmed	Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.	AKR1C1 AKR1C2	3.64e-05	5	67	2	18003893
Pubmed	A human MAP kinase interactome.	PARD6B POM121 LAMA4 ARHGEF11 CPLANE1 MAP2K5 RNF111	4.20e-05	486	67	7	20936779
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	GPD1 ANK2 SUPT16H LAMA4 BIRC6 AKR1C2 PLCE1	4.84e-05	497	67	7	23414517
Pubmed	The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.	AKR1C1 AKR1C2	5.46e-05	6	67	2	29107092
Pubmed	Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.	AKR1C1 AKR1C2	5.46e-05	6	67	2	19273550
Pubmed	Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.	AKR1C1 AKR1C2	5.46e-05	6	67	2	15860270
Pubmed	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.	ANK2 MBP	5.46e-05	6	67	2	31142747
Pubmed	Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	5.46e-05	6	67	2	15471942
Pubmed	MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.	AKR1C1 AKR1C2	5.46e-05	6	67	2	26748576
Pubmed	Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.	AKR1C1 AKR1C2	5.46e-05	6	67	2	17122075
Pubmed	Decidual prolactin silences the expression of genes detrimental to pregnancy.	AKR1C1 AKR1C2	5.46e-05	6	67	2	17255200
Pubmed	The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.	RPTOR RFX7	5.46e-05	6	67	2	29967452
Pubmed	The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.	AKR1C1 AKR1C2	7.63e-05	7	67	2	26160177
Pubmed	Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.	AKR1C1 AKR1C2	7.63e-05	7	67	2	34843575
Pubmed	MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.	AKR1C1 AKR1C2	7.63e-05	7	67	2	22529366
Pubmed	A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.	AKR1C1 AKR1C2	7.63e-05	7	67	2	33127481
Pubmed	Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels.	STAB2 TC2N	7.63e-05	7	67	2	21029358
Pubmed	Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.	AKR1C1 AKR1C2	7.63e-05	7	67	2	19846565
Pubmed	A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.	AKR1C1 AKR1C2	7.63e-05	7	67	2	12562828
Pubmed	17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.	AKR1C1 AKR1C2	7.63e-05	7	67	2	16337335
Pubmed	Topoisomerase II regulates the maintenance of DNA methylation.	SUPT16H DNMT1	7.63e-05	7	67	2	25451918
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SPATA31D4 SPATA31D3 PHF3 DLG3 MAP2K5	8.90e-05	233	67	5	37704626
Pubmed	Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.	AKR1C1 AKR1C2	1.02e-04	8	67	2	33584538
Pubmed	mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.	RPTOR MBP	1.02e-04	8	67	2	23524951
Pubmed	Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.	AKR1C1 AKR1C2	1.02e-04	8	67	2	20837989
Pubmed	Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.	AKR1C1 AKR1C2	1.02e-04	8	67	2	9224647
Pubmed	Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.	AKR1C1 AKR1C2	1.30e-04	9	67	2	33348080
Pubmed	Lack of placental neurosteroid alters cortical development and female somatosensory function.	AKR1C1 AKR1C2	1.63e-04	10	67	2	36313771
Pubmed	Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice.	CRLF2 DNMT1	1.63e-04	10	67	2	37163450
Pubmed	CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.	CISH CRLF2	1.63e-04	10	67	2	34290377
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHB11 PCDHB9 GBX2	1.95e-04	58	67	3	30377227
Pubmed	The aftiphilin/p200/gamma-synergin complex.	HEATR5A HEATR5B	1.99e-04	11	67	2	15758025
Pubmed	Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.	AKR1C1 AKR1C2	2.38e-04	12	67	2	21256921
Pubmed	Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.	MBP MAP2K5	2.38e-04	12	67	2	24975362
Pubmed	Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.	AKR1C1 AKR1C2	2.38e-04	12	67	2	28893949
Pubmed	Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles.	MBP LAMA4	2.38e-04	12	67	2	12843252
Pubmed	A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.	AKR1C1 AKR1C2	2.38e-04	12	67	2	25774556
Pubmed	The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.	AKR1C1 AKR1C2	2.81e-04	13	67	2	11682476
Pubmed	Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.	AKR1C1 AKR1C2	2.81e-04	13	67	2	17062636
Pubmed	Protocadherins.	PCDHB11 PCDHB9	2.81e-04	13	67	2	12231349
Cytoband	10p15-p14	AKR1C1 AKR1C2	3.14e-05	6	67	2	10p15-p14
Cytoband	9q21.32	SPATA31D4 SPATA31D3	3.53e-04	19	67	2	9q21.32
Cytoband	14q32.12	TC2N CATSPERB	8.30e-04	29	67	2	14q32.12
GeneFamily	Aldo-keto reductases	AKR1C1 AKR1C2	5.96e-04	15	44	2	399
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2U BIRC6	4.47e-03	41	44	2	102
GeneFamily	Phospholipases	PLD2 PLCE1	4.68e-03	42	44	2	467
GeneFamily	PDZ domain containing	PARD6B DLG3 ARHGEF11	6.00e-03	152	44	3	1220
GeneFamily	Olfactory receptors, family 52	OR52B2 OR52J3	6.33e-03	49	44	2	165
Coexpression	GSE24142_DN2_VS_DN3_THYMOCYTE_DN	MBP DYNLT5 DAPK1 DLG3 TMEM131 RNF111	9.23e-06	199	64	6	M4558
Coexpression	GSE3982_MEMORY_CD4_TCELL_VS_BCELL_UP	CISH DLG3 CATSPERB AKR1C1 FRMD4B DNMT1	9.23e-06	199	64	6	M5384
Coexpression	GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_T425A_HEXON_INF_DN	ANKRD13B MBP DLG3 ARHGEF11 CPLANE1 NXPE3	9.23e-06	199	64	6	M9295
Coexpression	BRUINS_UVC_RESPONSE_EARLY_LATE	CISH UBN1 PHF3 DLG3 STIL FAM228A RNF111	1.19e-05	316	64	7	M2248
Coexpression	BRUINS_UVC_RESPONSE_EARLY_LATE	CISH UBN1 PHF3 DLG3 STIL FAM228A RNF111	1.30e-05	320	64	7	MM1063
Coexpression	GSE21033_1H_VS_24H_POLYIC_STIM_DC_DN	ANKRD13B MFNG IFI35 BAIAP3 CRLF2	6.23e-05	171	64	5	M7729
Coexpression	GSE24081_CONTROLLER_VS_PROGRESSOR_HIV_SPECIFIC_CD8_TCELL_DN	PARD6B DLG3 STIL CPS1 IFI35	1.21e-04	197	64	5	M4540
Coexpression	GSE33513_TCF7_KO_VS_HET_EARLY_THYMIC_PROGENITOR_UP	CISH STAB2 PTPRZ1 IFI35 UBE2U	1.27e-04	199	64	5	M5105
Coexpression	GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_FETAL_DN	MBP DYNLT5 DAPK1 DLG3 TMEM131	1.27e-04	199	64	5	M4571
Coexpression	GSE15735_2H_VS_12H_HDAC_INHIBITOR_TREATED_CD4_TCELL_UP	CISH TEX2 DAPK1 CRLF2 NXPE3	1.30e-04	200	64	5	M7159
Coexpression	GSE7852_THYMUS_VS_FAT_TCONV_DN	MBP DAPK1 PLD2 BAIAP3 FRMD4B	1.30e-04	200	64	5	M5750
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	POM121 PHF3 SUPT16H HEATR5A ZDBF2 STIL RFX7 BIRC6 DNMT1 RNF111	3.48e-06	532	63	10	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	STAB2 TC2N HMCN1 LAMA4 CATSPERB AKR1C2 PLCE1	1.62e-08	195	66	7	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STAB2 TC2N LAMA4 CATSPERB FRMD4B PLCE1	2.54e-07	177	66	6	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N PTPRZ1 SPRR3 AKR1C1 AKR1C2	4.80e-06	166	66	5	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N PTPRZ1 SPRR3 AKR1C1 AKR1C2	4.80e-06	166	66	5	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B PKHD1 DAPK1 HEATR5A AKR1C1	6.55e-06	177	66	5	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	COVID-19-Heart-Lymph_EC\|Heart / Disease (COVID-19 only), tissue and cell type	STAB2 TC2N DAPK1 CATSPERB FRMD4B	6.92e-06	179	66	5	411620201a860716a8773b92f50f7b94ef34a586
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 HMCN1 PKHD1 CPS1 PLCE1	7.91e-06	184	66	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 HMCN1 PKHD1 CPS1 PLCE1	7.91e-06	184	66	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 HMCN1 PKHD1 CPS1 PLCE1	7.91e-06	184	66	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COPD-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	PARD6B SPRR3 CATSPERB AKR1C1 AKR1C2	8.34e-06	186	66	5	d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 FA2H PKHD1	8.55e-06	187	66	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 TC2N ANK2 LAMA4 PLCE1	9.24e-06	190	66	5	a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 TC2N ANK2 LAMA4 PLCE1	9.24e-06	190	66	5	0bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 TC2N ANK2 LAMA4 PLCE1	9.24e-06	190	66	5	26e2237f65cb43723c5da853831b40df2982d6e4
ToppCell	facs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 TC2N ANK2 LAMA4 PLCE1	9.48e-06	191	66	5	48823a97c38263f2c6e58348214f5b62773a6368
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 TC2N ANK2 LAMA4 PLCE1	9.48e-06	191	66	5	0eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1 CATSPERB	9.72e-06	192	66	5	39804d9ddc67c1b41887752df2503389eae44a1a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 FA2H PKHD1	9.72e-06	192	66	5	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 MBP CATSPERB	9.72e-06	192	66	5	8898332387e5d746feb346ce1dabd6b2218fc6e5
ToppCell	COPD-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	LAMA4 DAPK1 CATSPERB FRMD4B PLCE1	1.05e-05	195	66	5	e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1 CATSPERB	1.05e-05	195	66	5	d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 FA2H PKHD1	1.05e-05	195	66	5	98dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1 CATSPERB	1.07e-05	196	66	5	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1 CATSPERB	1.07e-05	196	66	5	0a34a0009f479384f1994c6f977f942699a132c8
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1 CATSPERB	1.07e-05	196	66	5	7b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCell	Control-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	TC2N LAMA4 CATSPERB FRMD4B PLCE1	1.07e-05	196	66	5	e0cf617b0f5d9c3c19574f587a3d0ccbf93d8ca4
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1 CATSPERB	1.10e-05	197	66	5	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SUPT16H LAMA4 DAPK1 FRMD4B	1.17e-05	94	66	4	d25f096626af873f724a8cd6454ed56e33fd9854
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SUPT16H LAMA4 DAPK1 FRMD4B	1.17e-05	94	66	4	2fb80a08f823295fa4c3e6494bf020e5b4052f0f
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DYNLT5 DAPK1 STIL AKR1C1	8.91e-05	158	66	4	74aa4f75307575ac3b2b1aa9f727753692f88742
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 PTPRZ1 PKHD1 CPS1	9.35e-05	160	66	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 PTPRZ1 PKHD1 CPS1	9.35e-05	160	66	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	DYNLT5 DAPK1 STIL AKR1C1	9.58e-05	161	66	4	58381131e651744b5141b202f9d6063f55432db5
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B FA2H PKHD1 AKR1C1	9.58e-05	161	66	4	1e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VPS4A CATSPERB PLD2 CPS1	1.00e-04	163	66	4	2d6fd2562d78be9f83fa35d811eb7e27eb8cc5d1
ToppCell	P07-Endothelial-lymphatic_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.00e-04	163	66	4	5cbab3d03bb1af9391ecad635d6eea1dd42c1337
ToppCell	P07-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.00e-04	163	66	4	322ba94c3ec1e1859c2e2195ecb3f7dab8d190f6
ToppCell	LPS-antiTNF-Epithelial_airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TC2N PTPRZ1 SPRR3 AKR1C1	1.08e-04	166	66	4	eb942ed68677e55c46cb039046f45686d4062d7c
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	STAB2 TC2N LAMA4 CATSPERB	1.10e-04	167	66	4	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	TC2N CATSPERB AKR1C1 AKR1C2	1.15e-04	169	66	4	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POM121 HMCN1 MBP ARHGEF11	1.21e-04	171	66	4	e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.32e-04	175	66	4	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.32e-04	175	66	4	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	facs-MAT-Fat-3m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH SPATA31D3 STAB2 FRMD4B	1.35e-04	176	66	4	71b3309ddadd035a1224fca4fc5946dc4c0283fe
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TC2N LAMA4 AKR1C1 AKR1C2	1.38e-04	177	66	4	64fbf799e7b0c4003b2f486cc41b0f7e7c11ea0c
ToppCell	P28-Endothelial-lymphatic_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.38e-04	177	66	4	6e330aa3c87fd640526b746a9deb3b2250d2518c
ToppCell	P28-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.38e-04	177	66	4	e96a7e4544710aaab8bd2800ecff9667880a8bf4
ToppCell	Control-Epithelial_alveolar-AT_1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B PKHD1 DAPK1 AKR1C1	1.41e-04	178	66	4	aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_THTPA\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TEX2 LAMA4 AKR1C1 AKR1C2	1.41e-04	178	66	4	e4e11e4940c911c17806200c25096928153c684d
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	TC2N CATSPERB AKR1C1 AKR1C2	1.50e-04	181	66	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B PKHD1 DAPK1 HEATR5A	1.50e-04	181	66	4	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PARD6B ANK2 PKHD1 DAPK1	1.50e-04	181	66	4	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TC2N LAMA4 AKR1C1 AKR1C2	1.50e-04	181	66	4	b9fe3833a6a56b9fbe5c257393fdbea5bf8ac4a3
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 TC2N LAMA4 CATSPERB	1.54e-04	182	66	4	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PARD6B ANK2 PKHD1 DAPK1	1.54e-04	182	66	4	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	P03-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.57e-04	183	66	4	89727b4f65949ed2dce9d2e0228c79fe4280230c
ToppCell	P03-Endothelial-lymphatic_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STAB2 TC2N LAMA4 PLCE1	1.57e-04	183	66	4	113e6d8d4bb271be984af06cd6c22b180425dcfc
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 TC2N LAMA4 CATSPERB	1.60e-04	184	66	4	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TC2N DAPK1 STIL DNMT1	1.60e-04	184	66	4	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	droplet-Lung-nan-21m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ANK2 LAMA4 PLCE1	1.63e-04	185	66	4	3a4ae836e882e8d29eb0a2dfab5677f10f2d365f
ToppCell	Control-Epithelial_alveolar\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B PKHD1 DAPK1 AKR1C1	1.63e-04	185	66	4	3937e026add96a396122139daf8011cfbc60e75c
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFNG ANK2 PTPRZ1 LAMA4	1.63e-04	185	66	4	0149981d3818a6250f32c08456c28e7037c39d91
ToppCell	droplet-Lung-nan-21m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 ANK2 LAMA4 PLCE1	1.63e-04	185	66	4	224f0b022c21dd40bf1f7503f00b3107ef958975
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARD6B TC2N PKHD1 DAPK1	1.67e-04	186	66	4	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	HMCN1 TMEM131 HEATR5A BIRC6	1.67e-04	186	66	4	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PARD6B PKHD1 LAMA4 DAPK1	1.70e-04	187	66	4	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PARD6B PKHD1 LAMA4 DAPK1	1.70e-04	187	66	4	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PARD6B PKHD1 LAMA4 DAPK1	1.70e-04	187	66	4	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	droplet-Lung-nan-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 PCDHB9 LAMA4 PLCE1	1.74e-04	188	66	4	a6ed43fdd42d681c9fbb2fb368947ab7e41d8d7c
ToppCell	droplet-Lung-nan-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 PCDHB9 LAMA4 PLCE1	1.74e-04	188	66	4	54550313db78b3b5b572fa1e67092c8f6f33aab5
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1	1.74e-04	188	66	4	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1	1.77e-04	189	66	4	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	HMCN1 DAPK1 AKR1C1 FRMD4B	1.77e-04	189	66	4	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 PCDHB9 LAMA4 PLCE1	1.81e-04	190	66	4	e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFNG STAB2 AKR1C1 AKR1C2	1.81e-04	190	66	4	32400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 PCDHB9 LAMA4 PLCE1	1.81e-04	190	66	4	f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1	1.81e-04	190	66	4	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 PCDHB9 LAMA4 PLCE1	1.81e-04	190	66	4	b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 ANK2 LAMA4 PLCE1	1.81e-04	190	66	4	f50b9814a1beac67dc042a8c27dfd085ceeda3a6
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFNG STAB2 AKR1C1 AKR1C2	1.81e-04	190	66	4	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 ANK2 LAMA4 PLCE1	1.81e-04	190	66	4	a22a510b4a257eb0eaf09c7ae7978d3d2f07a58c
ToppCell	IPF-Epithelial-Goblet\|IPF / Disease state, Lineage and Cell class	PARD6B CATSPERB AKR1C1 AKR1C2	1.81e-04	190	66	4	e41dd5a997ad9952810ffecb57737c03ea1d88b3
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	TC2N PTPRZ1 CATSPERB AKR1C1	1.81e-04	190	66	4	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 ANK2 LAMA4 PLCE1	1.81e-04	190	66	4	57c136bf6d7feafb4a220877bed0cc8fdf314db2
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Cbln1_(Layer_5a,_entorhinal_cortex_,_Cbln1+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	STAB2 TC2N OR52B2	1.81e-04	74	66	3	0be24b07a2503a16ece1489e765200be4c7253cc
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STIL BAIAP3 MAP3K19 PLCE1	1.85e-04	191	66	4	683e5c7e6173644f01e67c98ab7b75d7cb9cce99
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TC2N PTPRZ1 PKHD1 STIL	1.85e-04	191	66	4	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	GPD1 HEATR5B AKR1C1 AKR1C2	1.85e-04	191	66	4	a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1	1.88e-04	192	66	4	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFNG ANK2 PTPRZ1 LAMA4	1.88e-04	192	66	4	3fc7a661ef39286abfd82ed8ab580011f01cb8fd
ToppCell	COVID-19-lung-Lymphatic_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STAB2 TC2N LAMA4 CATSPERB	1.88e-04	192	66	4	cbe57cda44232b183821ac633b60a2668265e616
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 LAMA4 AKR1C1 AKR1C2	1.88e-04	192	66	4	5388f3115ab285f3f3001af1d71543ed64b9e044
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N ANK2 PKHD1	1.88e-04	192	66	4	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	COPD-Epithelial-Goblet\|COPD / Disease state, Lineage and Cell class	FA2H SPRR3 CATSPERB AKR1C1	1.88e-04	192	66	4	93b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1	1.88e-04	192	66	4	1aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	HMCN1 DAPK1 AKR1C1 FRMD4B	1.92e-04	193	66	4	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPRZ1 DYNLT5 CPLANE1 MAP3K19	1.92e-04	193	66	4	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PARD6B TC2N PTPRZ1 PKHD1	1.92e-04	193	66	4	ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 LAMA4 AKR1C1 AKR1C2	1.92e-04	193	66	4	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	TC2N CATSPERB AKR1C1 AKR1C2	1.92e-04	193	66	4	dc17f3b9758936d428cf17f77a1ce6d4c479b165
Drug	Methylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; PC3; HT_HG-U133A	UBN1 PHF3 GBX2 PLD2 IFI35 MAP2K5 NXPE3	1.34e-06	194	65	7	7137_DN
Drug	20-alpha-Dihydroprogesterone	MBP AKR1C1 AKR1C2	1.84e-06	9	65	3	ctd:D004092
Drug	(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE	AKR1C1 AKR1C2	8.03e-06	2	65	2	DB07768
Drug	cyclopentanone	AKR1C1 AKR1C2	2.40e-05	3	65	2	ctd:C007201
Drug	5-dihydrodeoxycorticosterone	AKR1C1 AKR1C2	2.40e-05	3	65	2	ctd:C454687
Drug	4-benzoylbenzoic acid	AKR1C1 AKR1C2	2.40e-05	3	65	2	ctd:C058818
Drug	cyclopentanol	AKR1C1 AKR1C2	2.40e-05	3	65	2	ctd:C016327
Drug	dichloro(4-cymene)ruthenium(II)	AKR1C1 AKR1C2	2.40e-05	3	65	2	ctd:C530610
Drug	tetrahydrodeoxycorticosterone	AKR1C1 AKR1C2	4.80e-05	4	65	2	ctd:C009413
Drug	Pregnanes	AKR1C1 AKR1C2	4.80e-05	4	65	2	ctd:D011278
Drug	tetralol	AKR1C1 AKR1C2	4.80e-05	4	65	2	ctd:C019106
Drug	gliquidone	AKR1C1 AKR1C2	4.80e-05	4	65	2	ctd:C010969
Drug	3',3'',5',5''-tetrabromophenolphthalein	AKR1C1 AKR1C2	4.80e-05	4	65	2	ctd:C018156
Drug	cloxazolam	AKR1C1 AKR1C2	4.80e-05	4	65	2	ctd:C005522
Drug	Hydroxysteroids	AKR1C1 AKR1C2	7.98e-05	5	65	2	ctd:D006914
Drug	NSC86000	AKR1C1 AKR1C2	7.98e-05	5	65	2	CID000257630
Drug	cresolphthalein	AKR1C1 AKR1C2	7.98e-05	5	65	2	ctd:C010092
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	1.30e-05	3	62	2	C0027661
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	4.33e-05	5	62	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	4.33e-05	5	62	2	C0033804
Disease	Hermaphroditism	AKR1C1 AKR1C2	4.33e-05	5	62	2	C0019269
Disease	Intersex Conditions	AKR1C1 AKR1C2	4.33e-05	5	62	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	4.33e-05	5	62	2	C2930619
Disease	X-16570 measurement	FA2H CPS1	6.48e-05	6	62	2	EFO_0800759
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	9.06e-05	7	62	2	C0036875
Disease	N-palmitoylglycine measurement	FA2H CPS1	9.06e-05	7	62	2	EFO_0800342
Disease	response to methotrexate	AKR1C1 AKR1C2	5.11e-04	16	62	2	GO_0031427
Disease	mean platelet volume	PWWP2A UBN1 TEX2 DLG3 CATSPERB STIL CPS1 PLCE1	1.28e-03	1020	62	8	EFO_0004584
Disease	factor VIII measurement, von Willebrand factor measurement	STAB2 TC2N	1.47e-03	27	62	2	EFO_0004629, EFO_0004630
Disease	obesity	RPTOR PKHD1 ZDBF2 MAP2K5	1.67e-03	241	62	4	EFO_0001073
Disease	Ischemic stroke, von Willebrand factor measurement	STAB2 TC2N	1.82e-03	30	62	2	EFO_0004629, HP_0002140
Disease	Carcinoma, Granular Cell	DAPK1 DNMT1 PLCE1	1.89e-03	116	62	3	C0205644
Disease	Adenocarcinoma, Tubular	DAPK1 DNMT1 PLCE1	1.89e-03	116	62	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	DAPK1 DNMT1 PLCE1	1.89e-03	116	62	3	C0205642
Disease	Carcinoma, Cribriform	DAPK1 DNMT1 PLCE1	1.89e-03	116	62	3	C0205643
Disease	Adenocarcinoma, Basal Cell	DAPK1 DNMT1 PLCE1	1.89e-03	116	62	3	C0205641
Disease	Adenocarcinoma	DAPK1 DNMT1 PLCE1	1.89e-03	116	62	3	C0001418
Disease	temporal lobe epilepsy (biomarker_via_orthology)	PTPRZ1 MBP	1.94e-03	31	62	2	DOID:3328 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DGKPEPLVFHIPQSF	C2orf42	381	Q9NWW7
SIVKVTVPPFVDPLF	FAM228A	51	Q86W67
IVPVEHLTPFPCGIF	DAPK1	1131	P53355
GFPVKHEPVFIRLNP	C4orf33	11	Q8N1A6
VAAPGFFIHPSDVIP	BIRC6	1681	Q9NR09
FFIHPSDVIPPTPKT	BIRC6	1686	Q9NR09
VPCLPHIFKGIKIFP	CATSPERB	341	Q9H7T0
GEKLPLFPEPLHVFA	DNMT1	1321	P26358
SDPFVIVELGPPHLF	BAIAP3	1046	O94812
GPPKHFPVVTVNHIL	DYNLT5	71	Q8N7M0
FHIPLSPVEVKPGNV	ARHGEF11	551	O15085
PPATAVHLKLVQPFV	CISH	201	Q9NSE2
VTPHGLEKVPGIFIS	PARD6B	181	Q9BYG5
TKFLGPVIVEIPHFA	ANK2	1071	Q01484
LPPGFPVKIEIPIFH	ANKRD13B	411	Q86YJ7
GQVPLFSDPIRHKFP	ERVFC1-1	316	P60608
VPFSVPKIPLVFRGH	IFI35	41	P80217
PVLPVGEFSEPFVHF	MAP2K5	381	Q13163
VTIFHPAVFVLPGIP	OR52B2	6	Q96RD2
HAVVVGVYRPPPKVK	FBL	306	P22087
PISDDVGAIPIKHFP	PTPRZ1	1691	P23471
PDPKSIFPGLFEIHQ	CRLF2	266	Q9HC73
FALVPFHDPEIGPVT	HMCN1	81	Q96RW7
SVPKGPFPGHLVDVS	PCDHB11	726	Q9Y5F2
KVVPAYVPTPIHPIF	POM121	1016	Q96HA1
HKAPFDGSRLVFPPV	FA2H	261	Q7L5A8
PKKPGPTILHFAVRF	FRMD4B	126	Q9Y2L6
FFAVQFHPEVTPGPI	CPS1	371	P31327
PKIVVPIPVHVSRFA	GBX2	321	P52951
RFATVPEPEFPGHVI	HEATR5A	1296	Q86XA9
IIKKFASVPEPEFPG	HEATR5B	1321	Q9P2D3
SIEFGPAEFIPLHPL	CPLANE1	356	Q9H799
EKIHPFTIPAIIRPF	FASTKD1	566	Q53R41
NPHVPDDPGIFITKI	DLG3	151	Q92796
GHKLPPNVVAVPDVV	GPD1	66	P21695
LVVADVVVPGHGPPF	MBLAC1	221	A4D2B0
VHFFKNIVTPRTPPP	MBP	221	P02686
HITFPVDGSPKEPVI	MAP3K19	486	Q56UN5
PGPPKLQLHDVFIAV	MFNG	46	O00587
KPIDHREPVFVGGVP	LAMA4	1761	Q16363
TGEFKFLKPITPHLP	PCDHB9	761	Q9Y5E1
KSIFHPVTFFLIGIP	OR52J3	6	Q8NH60
FGPHGIPVTVFPKRE	PWWP2A	196	Q96N64
LPSDGKEVPFVVPKF	TC2N	66	Q8N9U0
HRQVPDVGPVPFVKS	NXPE3	86	Q969Y0
VTVHGVPGPEPFTVF	PLCE1	2016	Q9P212
FKVHVPISIIPGDFP	SPATA31D4	661	Q6ZUB0
PHVFLGESFIPPTLV	PKHD1	3506	P08F94
PVFGIATPFHIATIK	SUPT16H	541	Q9Y5B9
LAISVIPPPKFAVVF	STRC	1686	Q7RTU9
RNPGVPSVVKFHPFT	RPTOR	1021	Q8N122
GFIKFPEPGAIKVPE	SPRR3	121	Q9UBC9
IHFPVSVKPGEEVIP	AKR1C1	116	Q04828
IHFPVSVKPGEEVIP	AKR1C2	116	P52895
FKVHVPISIIPGDFP	SPATA31D3	661	P0C874
VVRKEPDVPVFFPSG	STIL	876	Q15468
ILLHPEPIGAAKSFP	RNF111	36	Q6ZNA4
KHVVLPPSFPGKIVH	TMEM131	676	Q92545
VLEALPHVPPSFVGK	ZDBF2	1816	Q9HCK1
LGATDKIPHPLVPFD	PHF3	1316	Q92576
VKDLVGPGPFTVFAP	STAB2	1621	Q8WWQ8
APPVVKFITIPFHPN	UBE2U	66	Q5VVX9
VTPFGSPVTPEVHVF	RFX7	1096	Q2KHR2
AVPVPGPQVKVFHAG	UBN1	796	Q9NPG3
VQHPELPVKTLGFFI	TEX2	466	Q8IWB9
SLKVHPLVFAPGVPV	PLD2	51	O14939
LVSPHFPDIKGFVIV	TGM6	686	O95932
EAVILPIKFPHLFTG	VPS4A	141	Q9UN37