Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Depressed nasal bridge	POLR1A ANK1 TRIO UBE4B SYNE1 CEP290 HDAC8 PREPL DHX30 VANGL2 NF1 ASXL3 BUB1B AKT1 FUCA1 TAF1 MAP2K1 MED12	3.12e-05	612	54	18	HP:0005280
HumanPheno	Flattened nasal bridge	POLR1A ANK1 TRIO UBE4B SYNE1 CEP290 HDAC8 PREPL DHX30 VANGL2 NF1 ASXL3 BUB1B AKT1 FUCA1 TAF1 MAP2K1 MED12	3.12e-05	612	54	18	HP:0000425
HumanPheno	Abnormal calvaria morphology	TANC2 COL5A1 RPGRIP1L POLR1A TRIO GNE UBE4B RNPC3 SYNE1 CEP290 HDAC8 HECTD4 BMS1 NEB PREPL DHX30 VANGL2 NF1 ALMS1 ASXL3 BUB1B SYT1 AKT1 FUCA1 TAF1 MAP2K1 MED12	4.52e-05	1254	54	27	HP:0002683
HumanPheno	Macroorchidism	NF1 AKT1 MED12 PDE11A	4.82e-05	20	54	4	HP:0000053
HumanPheno	Long face	RPGRIP1L SYNE1 CEP290 NEB DHX30 NF1 SLC25A1 AKT1 TAF1 MAP2K1 MED12	6.45e-05	259	54	11	HP:0000276
HumanPheno	Hirsutism	TRIO GNE UBE4B CEP290 HDAC8 ALMS1 ASXL3 AKT1 TAF1 PDE11A	7.09e-05	216	54	10	HP:0001007
HumanPheno	Abnormality of calvarial morphology	TANC2 COL5A1 RPGRIP1L POLR1A TRIO GNE UBE4B RNPC3 SYNE1 CEP290 HDAC8 HECTD4 BMS1 PREPL DHX30 VANGL2 NF1 ASXL3 BUB1B SYT1 AKT1 FUCA1 TAF1 MAP2K1 MED12	7.31e-05	1134	54	25	HP:0002648
HumanPheno	Multinodular goiter	KEAP1 ALMS1 PDE11A	9.04e-05	9	54	3	HP:0005987
Domain	AARP2CN	BMS1 TSR1	4.81e-05	2	130	2	SM00785
Domain	G_Bms1/Tsr1_dom	BMS1 TSR1	4.81e-05	2	130	2	IPR030387
Domain	AARP2CN	BMS1 TSR1	4.81e-05	2	130	2	IPR012948
Domain	AARP2CN	BMS1 TSR1	4.81e-05	2	130	2	PF08142
Domain	BMS1_TSR1_C	BMS1 TSR1	4.81e-05	2	130	2	IPR007034
Domain	RIBIOP_C	BMS1 TSR1	4.81e-05	2	130	2	PF04950
Domain	DUF663	BMS1 TSR1	4.81e-05	2	130	2	SM01362
Domain	G_BMS1	BMS1 TSR1	4.81e-05	2	130	2	PS51714
Domain	dsrm	ADARB2 DHX30 STAU1	3.44e-04	20	130	3	PF00035
Domain	DS_RBD	ADARB2 DHX30 STAU1	4.00e-04	21	130	3	PS50137
Domain	Spectrin	DRP2 TRIO SYNE1	5.27e-04	23	130	3	PF00435
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	A2M PMS1 NRDE2 SEMA3C MTMR12 PFKL ASH2L IBTK TSR1 BUB1B AACS RACGAP1 PYGB CHPF2 CRYBG3	4.35e-08	650	136	15	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 COL5A1 FLNC POLR1A BMS1 SPAG9 DHX30 STAU1 NF1 TSR1 AHNAK PYGB HECTD1 MED12	3.06e-07	653	136	14	22586326
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KANSL1L FLNC TRIO SYNE1 PEG3 CLASP2 GIT2 NEB PREPL ASH2L ALMS1 TAF1	6.50e-07	497	136	12	23414517
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	A2M VPS18 ATAD5 CEP290 SPAG9 GIT2 KEAP1 ALMS1 TSR1 AHNAK BUB1B RACGAP1 MED12	1.64e-06	645	136	13	25281560
Pubmed	Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms.	KEAP1 AKT1 MAP2K1	2.02e-06	7	136	3	24704364
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 VPS18 RNPC3 CEP290 MAGI3 SPAG9 KIAA2013 ALMS1 HECTD1 PCDH18 MED12	4.12e-06	493	136	11	15368895
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 MTMR12 TRIO MAGI3 CLASP2 NF1 ALMS1 SLC25A1 AHNAK BUB1B RACGAP1 CRYBG3 MAP2K1 HECTD1	7.64e-06	861	136	14	36931259
Pubmed	Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.	DAGLB FLNC ANK1 SRL	8.38e-06	33	136	4	8681137
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TANC2 ZNF536 DRP2 ATAD5 NEB PREPL ASH2L THAP2 BNIP3 NF1 ASXL3 DNAH11	8.41e-06	638	136	12	31182584
Pubmed	Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro.	NF1 AKT1 MAP2K1	9.43e-06	11	136	3	11435472
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	TANC2 USP34 PEG3 CLASP2 SPAG9 DHX30	1.17e-05	128	136	6	30995482
Pubmed	Ginsenoside Rh2 inhibits metastasis of glioblastoma multiforme through Akt-regulated MMP13.	AKT1 MMP13	1.52e-05	2	136	2	25835975
Pubmed	The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.	PRKX PRKY	1.52e-05	2	136	2	7633447
Pubmed	Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure.	FLNC TRIO	1.52e-05	2	136	2	16914736
Pubmed	Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.	OTOF SYT1	1.52e-05	2	136	2	21451027
Pubmed	Man to mouse--lessons learned from the distal end of the human X chromosome.	PRKX PRKY	1.52e-05	2	136	2	9414316
Pubmed	Profiles of PrKX expression in developmental mouse embryo and human tissues.	PRKX PRKY	1.52e-05	2	136	2	15879576
Pubmed	Molecular approach in the study of Alström syndrome: analysis of ten Spanish families.	RPGRIP1L ALMS1	1.52e-05	2	136	2	22876109
Pubmed	A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease.	CPB2 TAF1	1.52e-05	2	136	2	14717966
Pubmed	Protein kinase B phosphorylates AHNAK and regulates its subcellular localization.	AHNAK AKT1	1.52e-05	2	136	2	11535620
Pubmed	PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.	PRKX PRKY	1.52e-05	2	136	2	21684272
Pubmed	Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.	PRKX PRKY	1.52e-05	2	136	2	9302280
Pubmed	Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families.	OTOF MYO15A	1.52e-05	2	136	2	37189200
Pubmed	TAFI gene haplotypes, TAFI plasma levels and future risk of coronary heart disease: the PRIME Study.	CPB2 TAF1	1.52e-05	2	136	2	15978108
Pubmed	Association between thrombin-activatable fibrinolysis inhibitor (TAFI) and clinical outcome in patients with unstable angina pectoris.	CPB2 TAF1	1.52e-05	2	136	2	12876631
Pubmed	Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone.	RPGRIP1L CEP290	1.52e-05	2	136	2	33625872
Pubmed	Association of genotypes of thrombin-activatable fibrinolysis inhibitors with thrombotic microangiopathies--a pilot study.	CPB2 TAF1	1.52e-05	2	136	2	17327284
Pubmed	A novel murine PKA-related protein kinase involved in neuronal differentiation.	PRKX PRKY	1.52e-05	2	136	2	10729225
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	TRIO UBE4B SYNE1 CHCHD6 NF1 AHNAK CTNNA2 MAP2K1	1.58e-05	281	136	8	28706196
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ATAD5 CLASP2 GIT2 PFKL ASH2L DHX30 TSR1 TAF1 MAP2K1	1.62e-05	370	136	9	22922362
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TRIO CLASP2 KEAP1 IBTK ALMS1 CRYBG3 HECTD1	1.94e-05	209	136	7	36779422
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	USP34 BMS1 UBL4A CLASP2 TSNAX EIF3CL DHX30 STAU1 FNDC1 TSR1 BUB1B RACGAP1 AKT1 CTNNA2	2.89e-05	971	136	14	33306668
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 USP34 FLNC TRIO UBE4B HECTD4 UBL4A CLASP2 KIAA2013 DHX30 AHNAK PYGB AKT1 HECTD1 MED12	2.96e-05	1105	136	15	35748872
Pubmed	Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.	ERAP1 ITGAM STAT4	3.16e-05	16	136	3	19110536
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	USP34 ZNF536 RPGRIP1L POLR1A TRIO CEP290 CLASP2 STAU1 IBTK ALMS1 RACGAP1 HECTD1	3.30e-05	733	136	12	34672954
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	VPS18 RPGRIP1L TRIO ABCA13 APOB PFKL NEB ASXL3 SPAG17 HECTD1	3.62e-05	513	136	10	25798074
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 ZNF536 KEAP1 ALMS1 AHNAK BUB1B TAF1 CRYBG3 MED12	4.19e-05	418	136	9	34709266
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	PARP11 FLNC POLR1A BMS1 UBL4A MAGI3 CLASP2 KEAP1 TSNAX PFKL PREPL FUCA1 HECTD1 AKAP7	4.20e-05	1005	136	14	19615732
Pubmed	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.	APOB NF1	4.54e-05	3	136	2	11727199
Pubmed	Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing.	OTOF MYO15A	4.54e-05	3	136	2	31250571
Pubmed	Interleukin-32 stimulates osteosarcoma cell invasion and motility via AKT pathway-mediated MMP-13 expression.	AKT1 MMP13	4.54e-05	3	136	2	25846944
Pubmed	Idiopathic Restrictive Cardiomyopathy Is Primarily a Genetic Disease.	FLNC MYBPC3	4.54e-05	3	136	2	27339502
Pubmed	HDAC8 Prevents Anthrax Lethal Toxin-induced Cell Cycle Arrest through Silencing PTEN in Human Monocytic THP-1 Cells.	HDAC8 AKT1	4.54e-05	3	136	2	28509866
Pubmed	Frequency of the TAFI -438 G/A and factor XIIIA Val34Leu polymorphisms in patients with objectively proven pulmonary embolism.	CPB2 TAF1	4.54e-05	3	136	2	12958613
Pubmed	p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling.	AKT1 MAP2K1	4.54e-05	3	136	2	25843685
Pubmed	Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.	AKT1 MAP2K1	4.54e-05	3	136	2	25534823
Pubmed	The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.	ITGAM AKT1	4.54e-05	3	136	2	25092872
Pubmed	Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.	PRKX PRKY	4.54e-05	3	136	2	17980165
Pubmed	A role for immature myeloid cells in immune senescence.	ITGAM AKT1	4.54e-05	3	136	2	21148798
Pubmed	FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.	PRKX PRKY	4.54e-05	3	136	2	9154127
Pubmed	[A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells].	BNIP3 AKT1	4.54e-05	3	136	2	19799812
Pubmed	Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.	OTOF SYT1	4.54e-05	3	136	2	28696301
Pubmed	Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.	AKT1 MAP2K1	4.54e-05	3	136	2	26660732
Pubmed	Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein.	A2M CPB2	4.54e-05	3	136	2	8662763
Pubmed	Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways.	AKT1 MAP2K1	4.54e-05	3	136	2	16820947
Pubmed	Critical role of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages.	AKT1 MAP2K1	4.54e-05	3	136	2	17951252
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	POLR1A ATAD5 RNPC3 BMS1 KEAP1 DHX30 STAU1 IBTK TSR1 RACGAP1 HECTD1 MED12	4.61e-05	759	136	12	35915203
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	VPS18 ATAD5 UBL4A ALMS1 AHNAK RACGAP1 MED12	4.93e-05	242	136	7	34011540
Pubmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	UBE4B TLR6 NF1 HECTD1	5.24e-05	52	136	4	30655611
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	USP34 NRDE2 VPS18 POLR1A TRIO EIF3CL NF1 BUB1B AKT1 FUCA1 MAP2K1 PCDH18 AKAP7	6.20e-05	910	136	13	36736316
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNC POLR1A GNE UBE4B BMS1 CHCHD6 PFKL DHX30 STAU1 MEMO1 NF1 SLC25A1 AHNAK RACGAP1 PYGB MED12	8.19e-05	1353	136	16	29467282
Pubmed	Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.	UBL4A AKT1	9.06e-05	4	136	2	26195787
Pubmed	Molecular genetic analysis of 30 families with Joubert syndrome.	RPGRIP1L CEP290	9.06e-05	4	136	2	27434533
Pubmed	Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.	OTOF SYT1	9.06e-05	4	136	2	20926654
Pubmed	Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells.	AKT1 MMP13	9.06e-05	4	136	2	19633290
Pubmed	3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide.	RPGRIP1L CEP290	9.06e-05	4	136	2	22832925
Pubmed	RAF1-MEK1-ERK/AKT axis may confer NSCLC cell lines resistance to erlotinib.	AKT1 MAP2K1	9.06e-05	4	136	2	23923067
Pubmed	In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies.	CEP290 ALMS1	9.06e-05	4	136	2	31302159
Pubmed	Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population.	ITGAM STAT4	9.06e-05	4	136	2	30041578
Pubmed	FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells.	RACGAP1 AKT1	9.06e-05	4	136	2	38172354
Pubmed	MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly.	APOB MAP2K1	9.06e-05	4	136	2	17038630
Pubmed	Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis.	AKT1 MAP2K1	9.06e-05	4	136	2	28225038
Pubmed	Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia.	ITGAM AKT1	9.06e-05	4	136	2	30337485
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	A2M TANC2 TRIO MAGI3 CHCHD6 CLASP2 DHX30 STAU1 NF1	1.11e-04	475	136	9	31040226
Pubmed	GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.	ITGAM STAT4 KCNJ3	1.11e-04	24	136	3	24871463
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	UBE4B PEG3 HECTD4 CHCHD6 KEAP1 IBTK AHNAK HECTD1 SLC27A2	1.22e-04	481	136	9	28190767
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	DHX30 STAU1 AHNAK	1.26e-04	25	136	3	35211260
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	NRDE2 FLNC POLR1A ATAD5 GIT2 KEAP1 PFKL STAU1 IBTK AHNAK RACGAP1	1.37e-04	724	136	11	36232890
Pubmed	Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression.	AKT1 MMP13	1.51e-04	5	136	2	38251858
Pubmed	Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.	ITGAM STAT4	1.51e-04	5	136	2	19165918
Pubmed	Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk.	IBTK AKT1	1.51e-04	5	136	2	18596081
Pubmed	RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST.	NF1 MAP2K1	1.51e-04	5	136	2	23423222
Pubmed	Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 With Behçet's disease in Iranians.	ERAP1 STAT4	1.51e-04	5	136	2	26097239
Pubmed	Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo.	CDO1 SPAG9	1.51e-04	5	136	2	17074887
Pubmed	Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.	AKT1 MAP2K1	1.51e-04	5	136	2	17461449
Pubmed	Neurofibromatosis type 1 alternative splicing is a key regulator of Ras/ERK signaling and learning behaviors in mice.	NF1 AKT1	1.51e-04	5	136	2	28934393
Pubmed	Regulation of human myoblast differentiation by PEBP4.	AKT1 MAP2K1	1.51e-04	5	136	2	19197339
Pubmed	Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer.	CDO1 KEAP1	1.51e-04	5	136	2	31107239
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TANC2 FLNC VPS18 TRIO SYNE1 CLASP2 PFKL EIF3CL DHX30 STAU1 NF1 SYT1 PYGB CTNNA2 MAP2K1 DNAH11	1.56e-04	1431	136	16	37142655
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	FLNC ERAP1 CYP3A5 C11orf54 SPAG9 SLC27A2 MYBPC3	2.03e-04	304	136	7	32235678
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	PFKL BUB1B AKT1	2.20e-04	30	136	3	32867711
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	PARP11 VPS18 UBE4B CYP3A5 OR4D1 UBL4A CLASP2 KEAP1 PREPL ASH2L DHX30 NF1 SLC25A1 HECTD1 MED12	2.25e-04	1327	136	15	32694731
Pubmed	Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation.	ITGAM AKT1	2.25e-04	6	136	2	24642468
Pubmed	Negative regulation of mTOR activation by diacylglycerol kinases.	AKT1 MAP2K1	2.25e-04	6	136	2	21310925
Pubmed	Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.	FLNC MAP2K1	2.25e-04	6	136	2	9006895
Pubmed	Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways.	AKT1 MAP2K1	2.25e-04	6	136	2	24126911
Pubmed	HIV-1 Nef mediates Pak phosphorylation of Mek1 serine298 and elicits an active phospho-state of Pak2.	AKT1 MAP2K1	2.25e-04	6	136	2	23746211
Pubmed	The locus controlling pineal serotonin N-acetyltransferase activity (Nat-2) is located on mouse chromosome 11.	APOB ADH7	2.25e-04	6	136	2	8170356
Pubmed	Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation.	CDO1 SPAG9	2.25e-04	6	136	2	19470755
Pubmed	Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.	A2M AKT1	2.25e-04	6	136	2	15389876
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M DRP2 ANK1 ABCA13 APOB NEB ASXL3 MYO15A SPAG17 DNAH11	2.59e-10	184	135	10	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M DRP2 ANK1 ABCA13 APOB NEB ASXL3 MYO15A SPAG17 DNAH11	2.59e-10	184	135	10	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M DRP2 ANK1 ABCA13 APOB NEB ASXL3 MYO15A SPAG17 DNAH11	2.59e-10	184	135	10	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	background-Hepatocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	A2M CDO1 CYP3A5 PON3 CPB2 APOB SERPING1 SLC27A2	1.81e-07	200	135	8	787d35b5c2f2ad967ae14e99496a0299ac7e72fd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RPGRIP1L ABCA13 SYNE1 ANKRD18B SPAG17 CCDC191 DNAH11	2.16e-06	194	135	7	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Control-Classical_Monocyte-\|Control / Disease condition and Cell class	TANC2 PARP11 TAGAP THAP2 BUB1B SERPING1	2.87e-06	130	135	6	e55f522dab5a6c3af30ad87ac8b32166f660c314
ToppCell	Control-Classical_Monocyte-\|Classical_Monocyte / Disease condition and Cell class	TANC2 PARP11 TAGAP THAP2 BUB1B SERPING1	2.87e-06	130	135	6	4433b40b099845f113993b6ecf85ec594b4b9219
ToppCell	droplet-Bladder-nan-3m-Hematologic-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAGAP ITGAM OTOF MMP13 PLD4 MYBPC3	6.80e-06	151	135	6	a7b1a60d68f0ed17022fe4c97af64f9f08d39fa3
ToppCell	droplet-Lung-3m-Hematologic-myeloid-interstitial_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DAGLB TANC2 SRL MYO15A MMP13 PLD4	8.82e-06	158	135	6	9a6d9b541446a6aa9f8ed040b330dbb5c6447076
ToppCell	droplet-Lung-3m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DAGLB TANC2 SRL MYO15A MMP13 PLD4	8.82e-06	158	135	6	2438713d2a7e32c647ab3384237ed614f4ec8fec
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPB2 APOB SLC25A1 AACS SERPING1 SLC27A2	1.13e-05	165	135	6	d449a568664a81d9b5538e8f409301448a32ac37
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 ANK1 CKMT2 KCNJ3 SRL MYBPC3	1.29e-05	169	135	6	88aa2246ede582c2e11de63228d76f520889ecb3
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 ANK1 CKMT2 KCNJ3 SRL MYBPC3	1.29e-05	169	135	6	a6a5b00912b653fad2ca7f096deaf35c9ef85e5b
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ZNF536 ANK1 ADARB2 ABCG4 FNDC1 SLC27A2	1.29e-05	169	135	6	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 ANK1 CKMT2 KCNJ3 SRL MYBPC3	1.29e-05	169	135	6	42a9b8c77d2a4d68b01e4db38f8a1af53c9c814f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 ADARB2 FNDC1 SRL PCDH18	1.34e-05	170	135	6	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 NEB CKMT2 KCNJ3 SRL MYBPC3	1.43e-05	172	135	6	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 NEB CKMT2 KCNJ3 SRL MYBPC3	1.43e-05	172	135	6	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 ADARB2 SRL PCDH18 PDE11A	1.68e-05	177	135	6	fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3C ZNF536 MAGI3 ADARB2 STAT4 PCDH18	1.79e-05	179	135	6	c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3C ZNF536 PEG3 FNDC1 SYT1 PCDH18	1.79e-05	179	135	6	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 RGS5 ADCY8 SRL PRKX	2.03e-05	183	135	6	121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3C ZNF536 PEG3 FNDC1 SYT1 PCDH18	2.03e-05	183	135	6	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 ADCY8 CKMT2 FNDC1 SRL	2.09e-05	184	135	6	7d41784eac0935e77d6bc701f20c693adf998730
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M PMS1 ANK1 KCNJ3 SYT1 AKAP7	2.16e-05	185	135	6	cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 FLNC SEMA3C ANK1 FNDC1 SERPING1	2.36e-05	188	135	6	7191087d8754f5e8700e3d744cd920ee26db1e57
ToppCell	droplet-Fat-SCAT-30m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3C RGS5 ADH7 FNDC1 AHNAK SERPING1	2.43e-05	189	135	6	8161910a19089f8cc5a3f1fda039f41a2488f04f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 GNE ABCA13 CNNM1 KCNJ3 DNAH11	2.43e-05	189	135	6	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3C ZNF536 SYNE1 FNDC1 SYT1 PCDH18	2.43e-05	189	135	6	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	droplet-Fat-SCAT\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3C RGS5 ADH7 FNDC1 AHNAK SERPING1	2.43e-05	189	135	6	264c59de2adb8bee5bb57633d79d530a8829617b
ToppCell	droplet-Heart-nan-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 PEG3 KCNJ3 SERPING1 SRL PCDH18	2.51e-05	190	135	6	96a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 SYNE1 PEG3 FNDC1 SYT1 PCDH18	2.58e-05	191	135	6	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3C PEG3 FNDC1 FUCA1 PCDH18 AKAP7	2.74e-05	193	135	6	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SEMA3C ZNF536 ADARB2 FNDC1 SYT1 PCDH18	2.74e-05	193	135	6	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CDO1 FLNC SEMA3C PEG3 FNDC1 ASXL3	2.74e-05	193	135	6	09de51f8ac509e03d480ed3dc9dfe7e7defc59cb
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL5A1 FLNC DRP2 ADH7 FNDC1 SERPING1	2.82e-05	194	135	6	5594f7437448cb4b37d2d100f44d30c4a367df26
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL5A1 FLNC SEMA3C TRIO FNDC1 SERPING1	2.82e-05	194	135	6	7b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell	P15-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL5A1 ZNF536 RGS5 FNDC1 SERPING1 SYT1	2.82e-05	194	135	6	5f04d21c4e2d36e74b6c5889aa97fd98f75a0973
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 SYNE1 ADH7 SPAG17 SLC27A2 DNAH11	3.07e-05	197	135	6	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 SYNE1 ADH7 SPAG17 SLC27A2 DNAH11	3.07e-05	197	135	6	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RPGRIP1L SYNE1 CEP290 SPAG17 CCDC191 DNAH11	3.07e-05	197	135	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 SYNE1 ADH7 SPAG17 SLC27A2 DNAH11	3.07e-05	197	135	6	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	Fibroblast\|World / shred by cell class for bronchial biopsy	A2M COL5A1 CDO1 RGS5 SERPING1 PCDH18	3.07e-05	197	135	6	8bf9846228b6b6721b10375fe54a2fb389ff64a6
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 ADARB2 ANKRD18B ADH7 ASXL3 MMP13	3.07e-05	197	135	6	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 SYNE1 ADH7 SPAG17 SLC27A2 DNAH11	3.07e-05	197	135	6	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M COL5A1 ZNF536 FNDC1 CRYBG3 PCDH18	3.16e-05	198	135	6	7582ee9ec8a87ecb094201f1f9191b412f9d2875
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M COL5A1 FNDC1 SERPING1 CRYBG3 PCDH18	3.25e-05	199	135	6	a272c54baf8de59c0f259e6498d144a0de8d8924
ToppCell	ILEUM-non-inflamed-(8)_Fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	A2M COL5A1 FNDC1 SERPING1 CRYBG3 PCDH18	3.25e-05	199	135	6	d9d7f36b4b5592b7855448730044c90997b55499
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL5A1 SEMA3C SYNE1 FNDC1 SYT1 PCDH18	3.25e-05	199	135	6	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 ANK1 ADARB2 SRL PCDH18 PDE11A	3.34e-05	200	135	6	9f21e4e0913d8ef95a3f771dff0abaad8fe1d9f2
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	COL5A1 CDO1 FLNC SEMA3C FNDC1 PCDH18	3.34e-05	200	135	6	fee22a6a6c7b93af204b5b56f2c34f1411500e18
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M COL5A1 FNDC1 SERPING1 CRYBG3 PCDH18	3.34e-05	200	135	6	c5d818203bef80ff97c2e0158cf61970673dd258
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 ANK1 ADARB2 FNDC1 PCDH18 PDE11A	3.34e-05	200	135	6	0ff2607c58bc929e203f407ecf3605e0b21bfa90
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	COL5A1 CDO1 FLNC SEMA3C FNDC1 PCDH18	3.34e-05	200	135	6	64d2941689d7ca8af54f9ba21c5aeabf719084ef
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M COL5A1 FNDC1 SERPING1 CRYBG3 PCDH18	3.34e-05	200	135	6	c0ea7cbc9d5e999530888145ce9e4c232fc874de
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA13 ADARB2 ANKRD18B ADH7 ASXL3 MMP13	3.34e-05	200	135	6	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF536 ANK1 ADARB2 FNDC1 PCDH18 PDE11A	3.34e-05	200	135	6	de23a5d22d94935802b5b84a9e029b3f62c57028
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	COL5A1 CDO1 FLNC SEMA3C FNDC1 PCDH18	3.34e-05	200	135	6	76f3043cb88071256ff661885fe5a82a54f5b733
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF536 RPGRIP1L RGS5 MYO15A SPAG17	4.61e-05	129	135	5	cbeeaa554da971ba2e4c4b82c85a1d070a45abb8
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA3C ZNF536 ADARB2 PCDH18 AKAP7	6.58e-05	139	135	5	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA3C ZNF536 MAGI3 ADARB2 PCDH18	7.78e-05	144	135	5	7de962346ba9653d90dd13bb7d977fe44d200bba
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ANK1 ADCY8 ABCG4 FNDC1 SLC27A2	8.03e-05	145	135	5	8b13b576fd2e6e33ccb146860a91a53cee0cdd4d
ToppCell	droplet-Liver-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 CPB2 APOB SERPING1 SLC27A2	8.30e-05	146	135	5	d9df42f8e44018b149a84f07c540cdba74d6374a
ToppCell	droplet-Liver-hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 CPB2 APOB SERPING1 SLC27A2	8.30e-05	146	135	5	a9fa64617c7fb7a66de77360c5642c1da91e465c
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 CPB2 APOB SERPING1 SLC27A2	8.30e-05	146	135	5	e03658ead410d003e2b18fe94da086a38560b8e7
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 CPB2 APOB SERPING1 SLC27A2	8.30e-05	146	135	5	9d7122cc640500c7cd93230df06e331c31625bd5
ToppCell	facs-Liver-Non-hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 ANK1 APOB SERPING1 SLC27A2	8.85e-05	148	135	5	5c853637f6058f78608ba0e76cda72a548d40710
ToppCell	facs-Liver-Non-hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 ANK1 APOB SERPING1 SLC27A2	8.85e-05	148	135	5	763c598826445bf627989220cd7acd71c4f1ea36
ToppCell	facs-Liver-Non-hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 ANK1 APOB SERPING1 SLC27A2	8.85e-05	148	135	5	d3f224128593251b72429a1cd52e82f77df8e386
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SEMA3C ZNF536 MAGI3 ADARB2 PCDH18	9.13e-05	149	135	5	10ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PON3 ADARB2 BUB1B RMC1 CCDC191	9.43e-05	150	135	5	9cb3332924bd67c966873343c14445e30d3f384f
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 APOB ADCY8 SERPING1 SLC27A2	9.73e-05	151	135	5	e243b6c76e59035f10519a86399b598dd2123f87
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 APOB ADCY8 SERPING1 SLC27A2	9.73e-05	151	135	5	cdd2ce0969da446616627e3569bbe5a5d9b475bd
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAGLB ANK1 ITGAM AHNAK PLD4	1.00e-04	152	135	5	b2e29fbda6b5f2d87cfc05423caf9cbf3b04ac65
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 APOB ADCY8 SERPING1 SLC27A2	1.07e-04	154	135	5	a5289000597068ee8d559f89bce7bce31f35dd57
ToppCell	facs-Skin-nan-24m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M CCNB3 ASXL3 SPAG17 PLD4	1.10e-04	155	135	5	fa2776d258e0420b2895de1008e292ad7725dac0
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SEMA3C ZNF536 ADARB2 PCDH18 PDE11A	1.10e-04	155	135	5	105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 APOB CKMT2 SLC27A2 MYBPC3	1.17e-04	157	135	5	8d30d8e6fae93afcada6bd68799439335cd65b69
ToppCell	facs-Heart-Unknown-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 APOB CKMT2 SLC27A2 MYBPC3	1.17e-04	157	135	5	2ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 APOB CKMT2 SLC27A2 MYBPC3	1.17e-04	157	135	5	8a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCell	facs-Heart-RV-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 RGS5 CKMT2 MYO15A MYBPC3	1.20e-04	158	135	5	2ef43d14ee65d004dc62c12ff209bbe12e4db681
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 CPB2 APOB SERPING1 SLC27A2	1.28e-04	160	135	5	8de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 ADCY8 CKMT2 MYO15A MYBPC3	1.28e-04	160	135	5	41d6c811c445c0ba9b6a2deb10a3b6b793172582
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 ADCY8 CKMT2 MYO15A MYBPC3	1.28e-04	160	135	5	c1d03c0ac9c12615a06499209fcdf18e9b6f1fba
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDO1 EXD1 APOB SERPING1 SLC27A2	1.31e-04	161	135	5	274838cebdc7af1db32d309dfe42ef7ccd3c190b
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SEMA3C ZNF536 PON3 FNDC1 DNAH11	1.39e-04	163	135	5	1e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRIO TAGAP CLASP2 AHNAK CCDC191	1.39e-04	163	135	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	A2M SEMA3C ZNF536 ADARB2 PDE11A	1.39e-04	163	135	5	bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell	3'-Adult-LargeIntestine-Epithelial-mature_enterocytic-Paneth\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EXD1 CEP290 APOB KCNJ3 ASXL3	1.52e-04	166	135	5	b64ab3d13b76bba3c305ebbfc96f983cd6ca30c9
ToppCell	367C-Fibroblasts-Fibroblast-G\|367C / Donor, Lineage, Cell class and subclass (all cells)	A2M CDO1 CYP3A5 APOB SERPING1	1.60e-04	168	135	5	8c95093b1ea45826f62893edd3c410fe53b563a4
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPB2 APOB SLC25A1 SERPING1 SLC27A2	1.60e-04	168	135	5	b98af4043dfa5dfa4413e482879fad88de484675
ToppCell	367C-Fibroblasts-Fibroblast-G-\|367C / Donor, Lineage, Cell class and subclass (all cells)	A2M CDO1 CYP3A5 APOB SERPING1	1.60e-04	168	135	5	b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPB2 APOB SLC25A1 SERPING1 SLC27A2	1.60e-04	168	135	5	073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3C ZNF536 ADARB2 VANGL2 PCDH18	1.65e-04	169	135	5	6a2ef66d7ff69a92e8c62759482e823a07352440
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_PENK\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 ANK1 ADARB2 PCDH18 DNAH11	1.65e-04	169	135	5	eb3b8e473192c4b8688f2f8da400116dd6fe193d
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	A2M CDO1 SERPING1 FUCA1 CRYBG3	1.65e-04	169	135	5	84b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL5A1 PEG3 CATSPER3 ADH7 SERPING1	1.65e-04	169	135	5	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNC ANK1 CKMT2 OTOF KCNJ3	1.69e-04	170	135	5	cb1ed6bd409ee1cf11be0d5e7cdcffe2ab220d38
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL5A1 SEMA3C ZNF536 MAGI3 ADARB2	1.69e-04	170	135	5	14aa86a4f526ed6986afcb28c49225522055550c
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNC ANK1 CKMT2 OTOF KCNJ3	1.69e-04	170	135	5	da4fb1e186e9bec6bba0b25f2a0e68f9e11c6017
Computational	Neighborhood of IGFBP1	CDO1 PON3 CPB2 APOB SLC27A2	1.15e-04	57	91	5	CAR_IGFBP1
Disease	Colorectal Carcinoma	CDO1 FLNC VPS18 ABCA13 SYNE1 PEG3 APOB ADARB2 ADCY8 NF1 CCNB3 BUB1B AKT1 SPAG17 DNAH8	5.15e-07	702	130	15	C0009402
Disease	Stuttering	USP34 ZNF536 OTOL1 STAT4 FUCA1 CTNNA2 AKAP7	3.48e-06	143	130	7	HP_0025268
Disease	vulva cancer (is_marker_for)	AKT1 MMP13	1.93e-05	2	130	2	DOID:1245 (is_marker_for)
Disease	urate measurement, bone density	COL5A1 UBE4B SYNE1 MAGI3 CATSPER3 CLASP2 PREPL FNDC1 CTNNA2 SLC30A9 DNAH8 DNAH11	1.99e-05	619	130	12	EFO_0003923, EFO_0004531
Disease	diabetic retinopathy (biomarker_via_orthology)	KEAP1 ITGAM AKT1 FUCA1	4.66e-05	45	130	4	DOID:8947 (biomarker_via_orthology)
Disease	polymyositis (is_implicated_in)	PMS1 STAT4	5.76e-05	3	130	2	DOID:0080745 (is_implicated_in)
Disease	dermatomyositis (is_implicated_in)	PMS1 STAT4	5.76e-05	3	130	2	DOID:10223 (is_implicated_in)
Disease	cerebral infarction (is_marker_for)	A2M APOB ITGAM	7.69e-05	19	130	3	DOID:3526 (is_marker_for)
Disease	Behcet Syndrome	ERAP1 APOB STAT4	1.58e-04	24	130	3	C0004943
Disease	Intellectual Disability	TANC2 TRIO SYNE1 PREPL NF1 SYT1 FUCA1 TAF1 CTNNA2	1.70e-04	447	130	9	C3714756
Disease	cerebellar ataxia (is_implicated_in)	RPGRIP1L SYNE1	1.91e-04	5	130	2	DOID:0050753 (is_implicated_in)
Disease	Neoplasm of uncertain or unknown behavior of ovary	PMS1 AKT1 MAP2K1	2.81e-04	29	130	3	C0496920
Disease	Ovarian Carcinoma	PMS1 AKT1 MAP2K1	3.11e-04	30	130	3	C0029925
Disease	acute myocardial infarction (is_marker_for)	ITGAM SERPING1	3.99e-04	7	130	2	DOID:9408 (is_marker_for)
Disease	Prostatic Neoplasms	PMS1 COL5A1 CYP3A5 KEAP1 TLR6 DHX30 BNIP3 AKT1 MMP13 MED12	4.14e-04	616	130	10	C0033578
Disease	Malignant neoplasm of prostate	PMS1 COL5A1 CYP3A5 KEAP1 TLR6 DHX30 BNIP3 AKT1 MMP13 MED12	4.14e-04	616	130	10	C0376358
Disease	cerebrospinal fluid clusterin measurement	ABCA13 MAGI3 CTNNA2	4.93e-04	35	130	3	EFO_0007657
Disease	vitamin K measurement	CDO1 CTNNA2	6.80e-04	9	130	2	EFO_0004618
Disease	ciliopathy (implicated_via_orthology)	RPGRIP1L CEP290 VANGL2	7.33e-04	40	130	3	DOID:0060340 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	TANC2 TRIO DHX30 ASXL3	7.76e-04	93	130	4	C1535926
Disease	Cutaneous Melanoma	NF1 AKT1 MAP2K1	7.88e-04	41	130	3	C0151779
Disease	diabetes mellitus (is_marker_for)	CPB2 APOB FUCA1	7.88e-04	41	130	3	DOID:9351 (is_marker_for)
Disease	Meckel-Gruber syndrome	RPGRIP1L CEP290	8.47e-04	10	130	2	cv:C0265215
Disease	Essential hypertension	CYP3A5 RGS5	8.47e-04	10	130	2	cv:C0085580
Disease	Essential hypertension, genetic	CYP3A5 RGS5	8.47e-04	10	130	2	cv:CN305331
Disease	HYPERTENSION, ESSENTIAL	CYP3A5 RGS5	8.47e-04	10	130	2	145500
Disease	Adenocarcinoma of large intestine	PMS1 AKT1 TAF1 MAP2K1	8.74e-04	96	130	4	C1319315
Disease	macrophage migration inhibitory factor measurement	ZNF208 CPB2 SUSD2	9.07e-04	43	130	3	EFO_0008221
Disease	cardiovascular disease	USP34 POLR1A EXD1 ERAP1 APOB GIT2 PCDH18 MYBPC3	9.76e-04	457	130	8	EFO_0000319
Disease	end stage renal disease (biomarker_via_orthology)	CYP3A5 KEAP1 BNIP3	1.18e-03	47	130	3	DOID:783 (biomarker_via_orthology)
Disease	Essential Hypertension	CYP3A5 RGS5	1.24e-03	12	130	2	C0085580
Disease	AL amyloidosis	CHPF2 DNAH11	1.24e-03	12	130	2	MONDO_0019438
Disease	Bipolar Disorder	ABCA13 SYNE1 TSNAX PFKL ITGAM ADCY8 AKT1 DNAH8	1.28e-03	477	130	8	C0005586
Disease	Ciliopathies	RPGRIP1L CEP290 DNAH8 DNAH11	1.45e-03	110	130	4	C4277690
Disease	Bardet-Biedl Syndrome	CEP290 ALMS1	1.46e-03	13	130	2	C0752166
Disease	intermediate coronary syndrome (is_marker_for)	ITGAM AKT1	1.46e-03	13	130	2	DOID:8805 (is_marker_for)
Disease	gallbladder cancer (is_implicated_in)	APOB KEAP1	1.46e-03	13	130	2	DOID:3121 (is_implicated_in)
Disease	lipoprotein A measurement	TAGAP APOB ADH7 FNDC1	1.55e-03	112	130	4	EFO_0006925
Disease	Drug habituation	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C0013170
Disease	Drug abuse	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C0013146
Disease	Prescription Drug Abuse	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C4316881
Disease	Substance-Related Disorders	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C0236969
Disease	Drug Use Disorders	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C0013222
Disease	Drug Dependence	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C1510472
Disease	Substance Dependence	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C0038580
Disease	Substance Use Disorders	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	SYNE1 ADARB2 DNAH8 AKAP7	1.70e-03	115	130	4	C0029231
Disease	Substance abuse problem	SYNE1 ADARB2 DNAH8 AKAP7	1.76e-03	116	130	4	C0740858
Disease	Meckel-Gruber syndrome	RPGRIP1L CEP290	1.95e-03	15	130	2	C0265215
Disease	periprosthetic osteolysis, disease progression measurement	RGS5 CTNNA2	1.95e-03	15	130	2	EFO_0008336, EFO_0009761
Disease	RASopathy	NF1 MAP2K1	1.95e-03	15	130	2	cv:C5555857
Disease	amenorrhea, response to antineoplastic agent	APOB ADCY8	1.95e-03	15	130	2	EFO_0010269, GO_0097327
Disease	systemic lupus erythematosus, COVID-19	KEAP1 ITGAM STAT4	2.16e-03	58	130	3	MONDO_0007915, MONDO_0100096
Disease	ureidopropionic acid measurement	RPGRIP1L ADARB2	2.22e-03	16	130	2	EFO_0010542
Disease	T-Cell Lymphoma	ASXL3 AKT1	2.22e-03	16	130	2	C0079772
Disease	sickle cell anemia (is_implicated_in)	APOB HBE1	2.22e-03	16	130	2	DOID:10923 (is_implicated_in)
Disease	coronary artery disease	DAGLB DXO SEMA3C DUS4L HECTD4 MAGI3 OTOL1 APOB ADARB2 FNDC1 SUSD2 MMP13 PCDH18	2.40e-03	1194	130	13	EFO_0001645
Disease	hypertension	ANK1 ERAP1 HECTD4 KIAA2013 ADH7 PCDH18	2.45e-03	307	130	6	EFO_0000537
Disease	C-reactive protein measurement	USP34 ZNF536 UBE4B APOB ADCY8 EIF3CL AHNAK AACS PYGB RMC1 AKAP7 DNAH11 MYBPC3	2.62e-03	1206	130	13	EFO_0004458
Disease	Meckel syndrome type 1	RPGRIP1L CEP290	2.81e-03	18	130	2	C3714506
Disease	essential hypertension (is_implicated_in)	CYP3A5 RGS5	2.81e-03	18	130	2	DOID:10825 (is_implicated_in)
Disease	bitter alcoholic beverage consumption measurement	ADH7 NF1 SLC25A1 RMC1	2.89e-03	133	130	4	EFO_0010092
Disease	HbA1c measurement	DXO ANK1 UBL4A PFKL ABCG4 SRL OR6Y1 MYO15A MYBPC3	3.09e-03	675	130	9	EFO_0004541
Disease	Congenital Myasthenic Syndromes, Presynaptic	PREPL SLC25A1	3.14e-03	19	130	2	C0751884
Disease	cortical surface area change measurement, age at assessment	ZNF536 SPAG9	3.14e-03	19	130	2	EFO_0008007, EFO_0021503
Disease	Familial aplasia of the vermis	RPGRIP1L CEP290	3.47e-03	20	130	2	cv:C0431399
Disease	bilirubin measurement	SEMA3C ANK1 UBL4A APOB ADH7 OR6Y1 DNAH11	3.52e-03	442	130	7	EFO_0004570
Disease	insomnia measurement	TANC2 ZNF536 STAU1 ALMS1 ASXL3 MAP2K1 DNAH11	3.56e-03	443	130	7	EFO_0007876
Disease	dentures	ADCY8 KCNJ3 MED12	3.69e-03	70	130	3	EFO_0010078
Disease	dental caries, dentures	ADCY8 KCNJ3 MED12	3.69e-03	70	130	3	EFO_0003819, EFO_0010078
Disease	COVID-19 (is_implicated_in)	A2M SERPING1	3.83e-03	21	130	2	DOID:0080600 (is_implicated_in)
Disease	chronic myeloid leukemia (is_implicated_in)	CYP3A5 AKT1	3.83e-03	21	130	2	DOID:8552 (is_implicated_in)
Disease	carotid artery intima media thickness	COL5A1 CEP170P1 APOB MEMO1 CTNNA2 HBE1 DNAH11	3.88e-03	450	130	7	EFO_0007117
Disease	progression free survival, ovarian serous carcinoma	ABCA13 CTNNA2	4.20e-03	22	130	2	EFO_0004920, EFO_1001516

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEFVDPKSHKFVMRL	VANGL2	501	Q9ULK5
PKSHKFVMRLQSETS	VANGL2	506	Q9ULK5
RFVSTPFHEIMSLKD	BUB1B	616	O60566
VSLAKPKHRVTMNEF	AKT1	136	P31749
TDDHVIKGTMVSKFP	ADH7	61	P40394
EHIKPFSLMFKDSSL	ADCY8	686	P40145
PSEDLFSFLKHKITM	ATAD5	1471	Q96QE3
TIHQPSAKLFEMFDK	ABCG4	256	Q9H172
DSRGQPFIKKMHFTI	CDY2A	261	Q9Y6F7
PFIKKMHFTIRLTES	CDY2A	266	Q9Y6F7
NFKKTLSHTDPMVLD	CATSPER3	326	Q86XQ3
ISQDKMSSFPLKITH	CRYBG3	851	Q68DQ2
SVLEEKAMKPVETHS	AACS	386	Q86V21
FPLATTDMKIAFTVH	ADGRG4	491	Q8IZF6
GESRSFKPHLTFMKL	AKAP7	211	Q9P0M2
TFTSGKLKEMFPIIA	CYP3A5	136	P20815
VLVSDKHRMSFPETV	ANK1	796	P16157
EPMKKFTTSITFSSH	ALMS1	2706	Q8TCU4
ELVDHLKKFSMSESP	ANKRD18B	636	A2A2Z9
KGIEPVHKDSISLFM	DNAH11	3031	Q96DT5
FHKDVIAEMSFVPKD	ABCA13	2291	Q86UQ4
HFKTPKISMPDVDFN	AHNAK	2306	Q09666
IHVAVTEMAALFPKK	GIT2	676	Q14161
LQAKIHMPEKTAVEF	DHX30	821	Q7L2E3
HMPEKTAVEFLSKAV	DHX30	826	Q7L2E3
FPKIMGVLTHLDSFK	BMS1	176	Q14692
EHPFVSSVDKSSVLM	ASXL3	1251	Q9C0F0
KQEDMKGHFSISIPV	A2M	516	P01023
FVIEPMTFKKTHKTE	CCNB3	206	Q8WWL7
TMSKERDVFLVKEHP	ASH2L	226	Q9UBL3
VVFKVSHKPSGLVMA	MAP2K1	81	Q02750
QKFREVTTDLTPMHA	ADARB2	371	Q9NS39
DMSTSVPKLFLHLEK	MSL3P1	301	P0C860
SSHVSPKIMETFKID	PCDH18	286	Q9HCL0
MKIEKSFDAHPRKES	SPAG9	1076	O60271
KMKTFHEPTTILGNS	KANSL1L	271	A0AUZ9
DMEKSHFTRDPSQLK	MAGI3	391	Q5TCQ9
VDKKVSFVDIMPHQS	RPGRIP1L	971	Q68CZ1
MVIILATHFGKEFTP	HBE1	111	P02100
TDPKNHTVMFDTLKD	MTMR12	196	Q9C0I1
STETHELMVKFPLKE	MYO15A	3446	Q9UKN7
PESKIRFVHKEMGII	ECHDC1	176	Q9NTX5
VMKDRPTHVVFKNTD	IBTK	126	Q9P2D0
MTPKHEFQASLSLKE	EXD1	431	Q8NHP7
FMEFVSVSVTHPELK	ERAP1	381	Q9NZ08
TPDMTHSEVEKAFKK	MMP13	126	P45452
IESPVVKFTKSFELM	PDE11A	431	Q9HCR9
PVTELKKDTDFEHRM	PFKL	721	P17858
FDDLVKMHIKSPTDF	DNAH8	1766	Q96JB1
DMFFLPHSVKEQAKI	FAM169B	31	Q8N8A8
HGMVNKPATFTIVTK	FLNC	1871	Q14315
FKTQHFVSAKTMPEL	FUCA1	201	P04066
VFHLVMPLFSGKEKS	NRDE2	716	Q9H7Z3
PHFEKFLTKSMAENR	METTL7B	101	Q6UX53
SETKVKKRHVDPFME	MED12	171	Q93074
KTPKGHSVFMDIFEL	HECTD4	36	Q9Y4D8
SLHKPEMETELKGSF	NUDT13	121	Q86X67
YVELKTSKEMHSPGQ	DXO	251	O77932
HGVIMEKFIKDVSRS	PEG3	311	Q9GZU2
PRAHAETTKMKVLEF	MAGEA13P	271	A6NCF6
IPFSRVNHSKFMVTE	PLD4	421	Q96BZ4
PEMFHKAEELFSKTT	PARP11	6	Q9NR21
PKMFAKGTEITHAVV	EIF3CL	316	B5ME19
KMLETVRTPALHFKS	APOB	1311	P04114
KVFPMEKLSSFSHEE	HECTD1	2471	Q9ULT8
SHKRMDITVFKPFID	GRHL1	451	Q9NZI5
EFLFKHPKRTATLSM	BNIP3	131	Q12983
KHISPVQALSEFKAM	CTNNA2	936	P26232
PVTTDIKHSIKMFEL	GNE	221	Q9Y223
PDMLTKIHIGSSFEK	CPB2	141	Q96IY4
PKTMIDLTEFRNSKH	CEP290	511	O15078
SHEAEFSKILIGPKM	DAGLB	621	Q8NCG7
KVTMTFHSKFGIRTP	CDO1	176	Q16878
TKMPVVFDRKASAAH	FNDC11	206	Q9BVV2
HSKAFIVAMPTTSKA	FNDC1	446	Q4ZHG4
FQSTHILPDEEKMVK	CCDC191	291	Q8NCU4
VAPGFVHTDMTKDLK	CBR4	176	Q8N4T8
MPTSSSFKHRIKEQE	CEP170P1	1	Q96L14
KTTKFLDRSDHPMID	COL5A1	186	P20908
TTFDPKKTRMEPFHF	SERPING1	301	P05155
HKVVLASSSPVFKAM	KEAP1	96	Q14145
KDPIEMFHSGQLVKV	DUS4L	16	O95620
FTSKVMTVSLHKFSP	HDAC8	191	Q9BY41
IKKPMSASALFVQDH	PMS1	571	P54277
HIQAIKLFKEEFSPM	DRP2	271	Q13474
VTSPKMLVDFLHETK	OR4D1	76	Q15615
TPHTKFTKKSEEREM	OTOL1	26	A6NHN0
HVSPDVMFDKIIKIS	OTOF	306	Q9HC10
PRVMKHTTDLDASKI	CKMT2	136	P17540
AKAMESHKDEFTIIP	MEMO1	141	Q9Y316
SKHDIIGEFKVPMNT	SYT1	236	P21579
KDFVVRHFKMSSPTD	SUSD2	76	Q9UGT4
RKEHNSKLTITFPAM	POLR1A	216	O95602
ELEVFKNHAPITTMK	SEMA3C	476	Q99985
SREIKKHSMSFTFAP	TAGAP	501	Q8N103
EAHKKLSEPLEVSFM	SYNE1	726	Q8NF91
PKEVNIDHFTKDITM	RGS5	126	O15539
EITGTFKHRKMTLVE	SLC27A2	566	O14975
FKHRKMTLVEEGFNP	SLC27A2	571	O14975
RMEDIKKAFPSHSES	TAF1	826	P21675
QFHEAASKMESTIKP	CHCHD6	176	Q9BRQ6
DFLTFVKMTGHDPII	PRORSD1P	151	A6NEY8
AKHFFALKVMSIPDV	PRKY	71	O43930
KMSVHRIITHPDFEK	PRSS47P	151	A8MTI9
DTIVSFLSKMIGKFP	TANC2	556	Q9HCD6
IIPHDFRRMKEFVST	ITGAM	161	P11215
VISPKMLVDFLSHDK	OR6Y1	81	Q8NGX8
SPHTKMDVANLAKVF	RACGAP1	486	Q9H0H5
SFPKMEETTKSHVTE	SPAG17	1826	Q6Q759
LMDVVSKKHPVDTLF	CHPF2	576	Q9P2E5
PHGKRVFSMFLETLV	CLASP2	706	O75122
LATHRFMATEVEPFK	CNNM1	611	Q9NRU3
KGKVKSHIMPAEFSS	C11orf54	211	Q9H0W9
RVVLSGHPFKIFTKM	TSR1	696	Q2NL82
IEFHISTDMPAAFKK	RNPC3	321	Q96LT9
PHMKNFVTKVSVGEF	STAU1	211	O95793
HFRAGTMSKLPKFEI	RMC1	181	Q96DM3
SAFVEKKEMPHKFVI	RMC1	466	Q96DM3
SVEFRHLQPKEMKSS	STAT4	396	Q14765
TSEFTVLMHGPKLKT	SRL	131	Q86TD4
KFFEMIENHPLSTKL	UBE4B	951	O95155
EKFGPLKHMVKDSST	VPS18	361	Q9P253
TTVAHKMKEHIPFFE	SERINC5	56	Q86VE9
PKDHVSKETESFRLM	ZNF620	101	Q6ZNG0
VKINPSSMFDVHVKR	PYGB	556	P11216
CPMETIKVKFIHDQT	SLC25A1	141	P53007
TKEEHMRPFNDFVKS	NF1	1456	P21359
KDGKLVPMTVFHKTD	PREPL	451	Q4J6C6
VNHPHMKSTVEIFKF	PON3	131	Q15166
AKHFFALKVMSIPDV	PRKX	71	P51817
MTKDKEPIVKSFHFV	TLR6	1	Q9Y2C9
HKDEMSSKASLFIRP	ZNF536	821	O15090
EIPKHMLADVFSVKT	TSNAX	266	Q99598
KGFSMFSILTKHEVI	ZNF208	896	O43345
RFLHPEVTETMEKGF	UBL4A	141	P11441
VKTPEELETFMLKHG	SLC30A9	521	Q6PML9
VPTIFDFCTHIKSMK	THAP2	76	Q9H0W7
FVLETFIHSKEKPTM	USP34	2311	Q70CQ2
VTPMISKHLEQKEAF	TRIO	1056	O75962
LFSPGVEMKKITDTH	KIAA2013	341	Q8IYS2
QPKKRAETLMFSEHA	KCNJ3	186	P48549
VVKVLFGDKMFHPHT	LIPK	221	Q5VXJ0
SAKLHFMEVKIDFVP	MYBPC3	626	Q14896
KTSFHTPVDMLSVVA	NEB	1866	P20929