Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein kinase A binding	NBEA LRBA RYR2 LRRK2	7.98e-06	58	44	4	GO:0051018
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5D KDM5A	7.08e-05	6	44	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5D KDM5A	1.32e-04	8	44	2	GO:0032453
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5D KDM5A	1.73e-03	28	44	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5D KDM5A	2.12e-03	31	44	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5D KDM5A	2.26e-03	32	44	2	GO:0140457
Domain	DUF1088	NBEA LRBA	5.42e-06	2	44	2	IPR010508
Domain	DUF1088	NBEA LRBA	5.42e-06	2	44	2	PF06469
Domain	Lys_sp_deMease-like_dom	KDM5D KDM5A	3.24e-05	4	44	2	IPR013637
Domain	PLU-1	KDM5D KDM5A	3.24e-05	4	44	2	PF08429
Domain	zf-C5HC2	KDM5D KDM5A	5.40e-05	5	44	2	PF02928
Domain	DUF4704	NBEA LRBA	5.40e-05	5	44	2	IPR031570
Domain	Znf_C5HC2	KDM5D KDM5A	5.40e-05	5	44	2	IPR004198
Domain	DUF4704	NBEA LRBA	5.40e-05	5	44	2	PF15787
Domain	PH_BEACH	NBEA LRBA	8.09e-05	6	44	2	PF14844
Domain	PH-BEACH_dom	NBEA LRBA	1.51e-04	8	44	2	IPR023362
Domain	-	NBEA LRBA	1.51e-04	8	44	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	1.51e-04	8	44	2	PS51783
Domain	BEACH_dom	NBEA LRBA	1.93e-04	9	44	2	IPR000409
Domain	BEACH	NBEA LRBA	1.93e-04	9	44	2	PS50197
Domain	Beach	NBEA LRBA	1.93e-04	9	44	2	PF02138
Domain	-	NBEA LRBA	1.93e-04	9	44	2	1.10.1540.10
Domain	Beach	NBEA LRBA	1.93e-04	9	44	2	SM01026
Domain	JmjN	KDM5D KDM5A	2.41e-04	10	44	2	SM00545
Domain	JMJN	KDM5D KDM5A	2.41e-04	10	44	2	PS51183
Domain	JmjN	KDM5D KDM5A	2.41e-04	10	44	2	PF02375
Domain	JmjN	KDM5D KDM5A	2.41e-04	10	44	2	IPR003349
Domain	ARM-like	CKAP5 NBEA LRBA CUL7 LRRK2	4.17e-04	270	44	5	IPR011989
Domain	-	KDM5D KDM5A	5.59e-04	15	44	2	1.10.150.60
Domain	BRIGHT	KDM5D KDM5A	5.59e-04	15	44	2	SM00501
Domain	ARID_dom	KDM5D KDM5A	5.59e-04	15	44	2	IPR001606
Domain	ARID	KDM5D KDM5A	5.59e-04	15	44	2	PS51011
Domain	ARID	KDM5D KDM5A	5.59e-04	15	44	2	PF01388
Domain	ARM-type_fold	CKAP5 NBEA LRBA CUL7 LRRK2	1.16e-03	339	44	5	IPR016024
Domain	JmjC	KDM5D KDM5A	1.45e-03	24	44	2	PF02373
Domain	-	NBEA LRBA NRXN2	1.45e-03	95	44	3	2.60.120.200
Domain	ConA-like_dom	NBEA LRBA NRXN2 RYR2	1.73e-03	219	44	4	IPR013320
Domain	-	CKAP5 LRBA CUL7 LRRK2	1.82e-03	222	44	4	1.25.10.10
Domain	JMJC	KDM5D KDM5A	2.57e-03	32	44	2	PS51184
Domain	JmjC_dom	KDM5D KDM5A	2.57e-03	32	44	2	IPR003347
Domain	JmjC	KDM5D KDM5A	2.73e-03	33	44	2	SM00558
Domain	PH_dom-like	NBEA RABGAP1 LRBA NET1 FRMD1	3.15e-03	426	44	5	IPR011993
Domain	-	CAPN14 RYR2 ANKEF1 STAT4	3.26e-03	261	44	4	1.10.238.10
Domain	EF-hand-dom_pair	CAPN14 RYR2 ANKEF1 STAT4	4.57e-03	287	44	4	IPR011992
Domain	LRR_8	SLITRK3 TLR5 LRRK2	7.59e-03	171	44	3	PF13855
Domain	Leu-rich_rpt_typical-subtyp	SLITRK3 TLR5 LRRK2	8.34e-03	177	44	3	IPR003591
Domain	LRR_TYP	SLITRK3 TLR5 LRRK2	8.34e-03	177	44	3	SM00369
Pathway	REACTOME_AURKA_ACTIVATION_BY_TPX2	CKAP5 CEP250 CEP63	4.97e-04	71	31	3	MM15495
Pathway	REACTOME_AURKA_ACTIVATION_BY_TPX2	CKAP5 CEP250 CEP63	5.18e-04	72	31	3	M27749
Pathway	REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES	CKAP5 CEP250 CEP63	7.32e-04	81	31	3	M748
Pathway	REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION	CKAP5 CEP250 CEP63	8.42e-04	85	31	3	MM14906
Pathway	REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION	CKAP5 CEP250 CEP63	9.01e-04	87	31	3	M27194
Pathway	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	CKAP5 CEP250 CEP63	9.94e-04	90	31	3	MM14979
Pathway	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	CKAP5 CEP250 CEP63	1.16e-03	95	31	3	M6729
Pathway	REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE	CKAP5 CEP250 CEP63	1.20e-03	96	31	3	MM15207
Pathway	REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE	CKAP5 CEP250 CEP63	1.23e-03	97	31	3	M27478
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	4.91e-06	3	45	2	28814779
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5D KDM5A	9.81e-06	4	45	2	16541399
Pubmed	H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.	KDM5A STAT4	9.81e-06	4	45	2	27050510
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CKAP5 RABGAP1 LRBA ANKHD1 KDM5A CSTPP1	1.59e-05	418	45	6	34709266
Pubmed	BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.	NBEA LRBA	1.63e-05	5	45	2	12160729
Pubmed	An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.	NBEA LRBA	2.45e-05	6	45	2	19482073
Pubmed	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.	RABGAP1 SENP5	4.56e-05	8	45	2	16608850
Pubmed	The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.	CKAP5 CEP250 CEP63	5.35e-05	56	45	3	11076968
Pubmed	The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.	CKAP5 CEP250 CEP63	5.64e-05	57	45	3	16462731
Pubmed	Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.	CKAP5 CEP250 CEP63	5.94e-05	58	45	3	12852856
Pubmed	Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.	CKAP5 CEP250 CEP63	6.91e-05	61	45	3	7790358
Pubmed	Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.	CKAP5 CEP250 CEP63	8.75e-05	66	45	3	12221128
Pubmed	Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes.	NBEA LRBA ATP9A	1.13e-04	72	45	3	34882091
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5D KDM5A	1.27e-04	13	45	2	24619213
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CNDP2 ANKHD1 NFE2L1	1.86e-04	85	45	3	15449545
Pubmed	Functional screen identifies regulators of murine hematopoietic stem cell repopulation.	NBEA STAT4	2.47e-04	18	45	2	26880577
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	CKAP5 NBEA LRBA ANKHD1 STX12	2.80e-04	449	45	5	31732153
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	CKAP5 ANKHD1 CSTPP1	3.66e-04	107	45	3	30995489
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	ANKHD1 CEP63	3.72e-04	22	45	2	12812986
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	CKAP5 LRBA CSTPP1 PDZD4	3.73e-04	263	45	4	34702444
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	KDM5A NFE2L1 SENP5	3.97e-04	110	45	3	26841866
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	CUL7 PABPC4	4.44e-04	24	45	2	33705438
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ANKHD1 NET1 NFE2L1 UNC5C CSTPP1 RAD17 CEP63	4.52e-04	1084	45	7	11544199
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	NBEA LRBA RYR2 UNC5C PABPC4 LRRK2	4.73e-04	777	45	6	35844135
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	NBEA RABGAP1 LRBA ATP9A STX12	4.75e-04	504	45	5	34432599
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	NBEA LRBA UNC5C STX12	5.05e-04	285	45	4	34369648
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	OTOP3 CEP250 ADD2	5.11e-04	120	45	3	21697133
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	NBEA RABGAP1 CUL7 ANKHD1	5.25e-04	288	45	4	23383273
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	NBEA LRBA	5.63e-04	27	45	2	19723784
Pubmed	Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.	CKAP5 RYR2	5.63e-04	27	45	2	18468998
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CKAP5 ATP9A ANKHD1 NET1 KDM5A CDK12 MBD3 PABPC4	6.01e-04	1497	45	8	31527615
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CKAP5 CUL7 NRXN2	6.46e-04	130	45	3	12421765
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5D KDM5A	8.43e-04	33	45	2	26864203
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	CKAP5 NBEA LRBA CUL7	8.63e-04	329	45	4	17474147
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CKAP5 CEP250 CEP63	9.04e-04	146	45	3	21399614
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	CNDP2 RABGAP1 LRBA STX12	9.64e-04	339	45	4	37232246
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	NBEA RABGAP1 CEP63	9.96e-04	151	45	3	17043677
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KDM5D KDM5A MBD3	1.11e-03	157	45	3	30186101
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CKAP5 SDE2 LRBA ANKHD1 CDK12 CSTPP1	1.23e-03	934	45	6	33916271
Cytoband	1p35.3	THEMIS2 STX12	5.17e-04	34	45	2	1p35.3
Cytoband	11p11.2	CKAP5 CSTPP1	3.04e-03	83	45	2	11p11.2
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	8.27e-05	9	28	2	1230
GeneFamily	AT-rich interaction domain containing	KDM5D KDM5A	2.40e-04	15	28	2	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5D KDM5A	6.25e-04	24	28	2	485
GeneFamily	EF-hand domain containing	CAPN14 RYR2 ANKEF1	4.59e-03	219	28	3	863
GeneFamily	PHD finger proteins	KDM5D KDM5A	8.52e-03	90	28	2	88
Coexpression	GSE37301_GRANULOCYTE_MONOCYTE_PROGENITOR_VS_RAG2_KO_NK_CELL_UP	PDP2 CUL7 NANS UNC5C RAD17	1.53e-05	183	45	5	M8832
Disease	autism spectrum disorder (implicated_via_orthology)	NBEA LRBA KDM5D NRXN2 KDM5A	3.51e-06	152	45	5	DOID:0060041 (implicated_via_orthology)
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5D KDM5A	1.36e-05	4	45	2	DOID:0060809 (implicated_via_orthology)
Disease	Systemic lupus erythematosus	STAT4 TLR5	1.24e-04	11	45	2	cv:C0024141
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5D KDM5A	2.69e-04	16	45	2	DOID:0050888 (implicated_via_orthology)
Disease	Autistic Disorder	NBEA CUL7 NRXN2 MBD3	6.70e-04	261	45	4	C0004352
Disease	IgA glomerulonephritis (is_implicated_in)	STAT4 ADD2	9.63e-04	30	45	2	DOID:2986 (is_implicated_in)
Disease	Papillary Renal Cell Carcinoma	CUL7 UNC5C LRRK2	9.90e-04	128	45	3	C1306837
Disease	Renal Cell Carcinoma	CUL7 UNC5C LRRK2	9.90e-04	128	45	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	CUL7 UNC5C LRRK2	9.90e-04	128	45	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	CUL7 UNC5C LRRK2	9.90e-04	128	45	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	CUL7 UNC5C LRRK2	9.90e-04	128	45	3	C1266044
Disease	Malignant neoplasm of breast	THEMIS2 LRBA NET1 ANKEF1 STAT4 STX12 PDZD4	1.12e-03	1074	45	7	C0006142
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	CUL7 UNC5C LRRK2	1.50e-03	148	45	3	C0279702
Disease	Alzheimer disease, polygenic risk score	LRBA NFE2L1 CSTPP1 PABPC4 LRRK2	1.93e-03	586	45	5	EFO_0030082, MONDO_0004975
Disease	mammographic density measurement	NBEA ADD2	2.66e-03	50	45	2	EFO_0005941
Disease	alcohol use disorder (implicated_via_orthology)	KDM5D KDM5A RYR2	3.29e-03	195	45	3	DOID:1574 (implicated_via_orthology)
Disease	Libman-Sacks Disease	STAT4 TLR5	3.56e-03	58	45	2	C0242380

Protein segments in the cluster

Peptide	Gene	Start	Entry
MDHDLMGLLESGLVH	CDK12	816	Q9NYV4
LQGDMRHMTLEGEEE	EIF2D	211	P41214
MRAAELGHELSMEIL	ANKEF1	86	Q9NU02
LHAAMREAGIMLSDD	CAPN14	611	A8MX76
LLDEAMLDEISLMDL	NFE2L1	441	Q14494
MLDEISLMDLAIEEG	NFE2L1	446	Q14494
LKMEALTDREHGMID	RAD17	596	O75943
HDPMLKLSIMSEEEL	NET1	201	Q7Z628
DVRNSDMHLLDLESM	RABGAP1	356	Q9Y3P9
TGMLLEIDNSELLHM	PABPC4	591	Q13310
SMHREIEAELGILME	OTOP3	251	Q7RTS5
EALMADMLAHVEELA	MBD3	241	O95983
GGEDMVRHLDEMDLS	IMPG1	511	Q17R60
LMMEGDLLEVTLDEN	KDM5D	1386	Q9BY66
RNESLGHEMAMLEEE	PDZD4	391	Q76G19
GHEMAMLEEELRHLE	PDZD4	396	Q76G19
MAEETDHLILLAIMT	PTGER2	256	P43116
HMLEILGFEEDIEDM	CUL7	426	Q14999
MELLDGHLYLLLDMG	NRXN2	556	Q9P2S2
TMHEDDNLMDVLQLL	LRBA	686	P50851
ALEMLSLEGAMDSVL	LRRK2	576	Q5S007
IESLEMEMELLCLTG	ATP9A	636	O75110
MEMELLCLTGVEDQL	ATP9A	641	O75110
GSELMEILDGMDQSH	CYHR1	196	Q6ZMK1
EELMMVGDLLEVSLD	KDM5A	1446	P29375
LLDLHMEMGLSIEEA	PDP2	216	Q9P2J9
MDAMASEHRDVLVLL	FRMD1	46	Q8N878
DLMHGLITLMLDSRI	CKAP5	1641	Q14008
LMHDPAMDEELERLL	CSTPP1	261	Q9H6J7
LSEMVMKLELGLHEA	CEP63	476	Q96MT8
IESLEQLLLDKHMGM	CPAMD8	1586	Q8IZJ3
LESELMELHETMASL	CEP250	1311	Q9BV73
HEMAERLEDSVLKGM	SDE2	161	Q6IQ49
HTMMFTLNGEILLDD	RYR2	1171	Q92736
DDMIADLLVDMLGVL	NBEA	171	Q8NFP9
MLDHIGRSLMELQLE	SLITRK3	216	O94933
ASGMDEMAVEFLHEL	NANS	111	Q9NR45
GEHEFEALMRMLDNL	ADD2	361	P35612
MEAAREGHEEMVALL	ANKHD1	476	Q8IWZ3
VHEAMTDLILLMGSL	CNDP2	236	Q96KP4
KHMLDMDDLATLDGQ	SENP5	566	Q96HI0
DTLMRDILGHELAAM	TULP2	6	O00295
MIGMLESLQHESDLL	ZNF260	1	Q3ZCT1
AMMIHDQGDLIDSIE	STX12	206	Q86Y82
HETDLLMNTMLIEEL	STAT4	221	Q14765
EDQLLMLEAVVMHLG	THEMIS2	126	Q5TEJ8
MHMGLLYEEDGQLLE	TTC29	186	Q8NA56
MGDHLDLLLGVVLMA	TLR5	1	O60602
LSMLAAVLEEMGRHE	UNC5C	906	O95185