Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	male germ-line stem cell population maintenance	TUBA3D JMJD1C	9.18e-06	2	63	2	GO:0036098
Domain	STAG	STAG1 STAG3	6.27e-05	4	61	2	IPR013721
Domain	SCD	STAG1 STAG3	6.27e-05	4	61	2	PS51425
Domain	SCD	STAG1 STAG3	6.27e-05	4	61	2	IPR020839
Domain	STAG	STAG1 STAG3	6.27e-05	4	61	2	PF08514
Domain	UBA	VPS13D DHX57 HUWE1	2.19e-04	36	61	3	PF00627
Domain	Alpha_tubulin	TUBA3D TUBA3E	3.72e-04	9	61	2	IPR002452
Domain	UBA	VPS13D DHX57 HUWE1	3.99e-04	44	61	3	IPR015940
Domain	UBA	VPS13D DHX57 HUWE1	4.85e-04	47	61	3	PS50030
Domain	UBA-like	VPS13D DHX57 HUWE1	1.20e-03	64	61	3	IPR009060
Domain	PDEase	PDE6C PDE8B	1.73e-03	19	61	2	IPR023088
Domain	-	TUBA3D TUBA3E	1.92e-03	20	61	2	3.30.1330.20
Domain	-	TUBA3D TUBA3E	2.12e-03	21	61	2	1.10.287.600
Domain	PDEase_I	PDE6C PDE8B	2.12e-03	21	61	2	PF00233
Domain	PDEASE_I	PDE6C PDE8B	2.12e-03	21	61	2	PS00126
Domain	PDEase_CS	PDE6C PDE8B	2.12e-03	21	61	2	IPR023174
Domain	Tubulin_C	TUBA3D TUBA3E	2.32e-03	22	61	2	SM00865
Domain	Tubulin_C	TUBA3D TUBA3E	2.32e-03	22	61	2	PF03953
Domain	Tubulin/FtsZ_2-layer-sand-dom	TUBA3D TUBA3E	2.32e-03	22	61	2	IPR018316
Domain	-	TUBA3D TUBA3E	2.32e-03	22	61	2	3.40.50.1440
Domain	-	PDE6C PDE8B	2.32e-03	22	61	2	1.10.1300.10
Domain	Tubulin_C	TUBA3D TUBA3E	2.54e-03	23	61	2	IPR023123
Domain	TUBULIN	TUBA3D TUBA3E	2.54e-03	23	61	2	PS00227
Domain	Tubulin	TUBA3D TUBA3E	2.54e-03	23	61	2	IPR000217
Domain	Tub_FtsZ_C	TUBA3D TUBA3E	2.54e-03	23	61	2	IPR008280
Domain	Tubulin	TUBA3D TUBA3E	2.54e-03	23	61	2	SM00864
Domain	PDEase_catalytic_dom	PDE6C PDE8B	2.54e-03	23	61	2	IPR002073
Domain	Tubulin_CS	TUBA3D TUBA3E	2.54e-03	23	61	2	IPR017975
Domain	HDc	PDE6C PDE8B	2.77e-03	24	61	2	SM00471
Domain	HD/PDEase_dom	PDE6C PDE8B	2.77e-03	24	61	2	IPR003607
Domain	Tubulin_FtsZ_GTPase	TUBA3D TUBA3E	2.77e-03	24	61	2	IPR003008
Domain	Tubulin	TUBA3D TUBA3E	2.77e-03	24	61	2	PF00091
Domain	UBA	VPS13D HUWE1	4.30e-03	30	61	2	SM00165
Domain	ARM-type_fold	STAG1 PIK3C2B HUWE1 RALGAPA2 STAG3	4.96e-03	339	61	5	IPR016024
Domain	MFS	SPNS2 SLC22A1 SLC22A11	5.31e-03	108	61	3	PS50850
Domain	MFS_sugar_transport-like	SLC22A1 SLC22A11	6.15e-03	36	61	2	IPR005828
Domain	Sugar_tr	SLC22A1 SLC22A11	6.15e-03	36	61	2	PF00083
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPG_TO_MICROTUBULE_RHOA_SIGNALING_PATHWAY	TUBA3D TUBA3E TUBA3C	2.93e-05	17	51	3	M47768
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_DCTN1_TO_RETROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	3.50e-05	18	51	3	M47753
Pathway	KEGG_MEDICUS_ENV_FACTOR_IRON_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	4.15e-05	19	51	3	M47818
Pathway	KEGG_MEDICUS_ENV_FACTOR_ZN_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	4.15e-05	19	51	3	M47813
Pathway	KEGG_MEDICUS_REFERENCE_KINETOCHORE_MICROTUBULE_ATTACHMENT	TUBA3D TUBA3E TUBA3C	4.87e-05	20	51	3	M47890
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_DEPOLYMERIZATION_AT_THE_MINUS_ENDS	TUBA3D TUBA3E TUBA3C	4.87e-05	20	51	3	M47911
Pathway	REACTOME_TRANSPORT_OF_CONNEXONS_TO_THE_PLASMA_MEMBRANE	TUBA3D TUBA3E TUBA3C	5.67e-05	21	51	3	M27067
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_RHOA_SIGNALING_PATHWAY	TUBA3D TUBA3E TUBA3C	5.67e-05	21	51	3	M47767
Pathway	KEGG_MEDICUS_REFERENCE_PROMOTION_OF_MICROTUBULE_GROWTH	TUBA3D TUBA3E TUBA3C	6.54e-05	22	51	3	M47903
Pathway	REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY	TUBA3D TUBA3E TUBA3C	7.51e-05	23	51	3	M19135
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_DEPOLYMERIZATION	TUBA3D TUBA3E TUBA3C	7.51e-05	23	51	3	M47910
Pathway	KEGG_MEDICUS_REFERENCE_KINETOCHORE_FIBER_ORGANIZATION	TUBA3D TUBA3E TUBA3C	7.51e-05	23	51	3	M47900
Pathway	KEGG_MEDICUS_REFERENCE_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	8.56e-05	24	51	3	M47671
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	8.56e-05	24	51	3	M47700
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	STAG1 TUBA3D TUBA3E TUBA3C KNL1	9.24e-05	127	51	5	M27181
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT	TUBA3D TUBA3E TUBA3C	9.70e-05	25	51	3	M47775
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	9.70e-05	25	51	3	M47710
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ANTEROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	1.09e-04	26	51	3	M47672
Pathway	REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC	TUBA3D TUBA3E TUBA3C	1.09e-04	26	51	3	M9648
Pathway	REACTOME_TRANSLOCATION_OF_SLC2A4_GLUT4_TO_THE_PLASMA_MEMBRANE	TUBA3D TUBA3E RALGAPA2 TUBA3C	1.30e-04	72	51	4	M26954
Pathway	KEGG_MEDICUS_REFERENCE_MICROTUBULE_NUCLEATION	TUBA3D TUBA3E TUBA3C	1.37e-04	28	51	3	M47898
Pathway	REACTOME_ACTIVATION_OF_AMPK_DOWNSTREAM_OF_NMDARS	TUBA3D TUBA3E TUBA3C	1.53e-04	29	51	3	M27948
Pathway	REACTOME_SEALING_OF_THE_NUCLEAR_ENVELOPE_NE_BY_ESCRT_III	TUBA3D TUBA3E TUBA3C	2.05e-04	32	51	3	M29848
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_IQGAPS	TUBA3D TUBA3E TUBA3C	2.05e-04	32	51	3	M27491
Pathway	REACTOME_COOPERATION_OF_PREFOLDIN_AND_TRIC_CCT_IN_ACTIN_AND_TUBULIN_FOLDING	TUBA3D TUBA3E TUBA3C	2.25e-04	33	51	3	M27297
Pathway	KEGG_MEDICUS_REFERENCE_BRANCHING_MICROTUBULE_NUCLEATION	TUBA3D TUBA3E TUBA3C	2.25e-04	33	51	3	M47901
Pathway	KEGG_MEDICUS_REFERENCE_ARL8_REGULATED_MICROTUBULE_PLUS_END_DIRECTED_TRANSPORT	TUBA3D TUBA3E TUBA3C	2.69e-04	35	51	3	M47774
Pathway	REACTOME_GAP_JUNCTION_ASSEMBLY	TUBA3D TUBA3E TUBA3C	3.44e-04	38	51	3	M14981
Pathway	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	TUBA3D TUBA3E JMJD1C TUBA3C KDM1A	3.61e-04	170	51	5	M941
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	4.97e-04	43	51	3	M47669
Pathway	KEGG_MEDICUS_REFERENCE_RAB7_REGULATED_MICROTUBULE_MINUS_END_DIRECTED_TRANSPORT	TUBA3D TUBA3E TUBA3C	4.97e-04	43	51	3	M47773
Pathway	REACTOME_AGGREPHAGY	TUBA3D TUBA3E TUBA3C	5.32e-04	44	51	3	M29830
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	TUBA3D TUBA3E TUBA3C	5.32e-04	44	51	3	M27934
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	TUBA3D TUBA3E TUBA3C	5.69e-04	45	51	3	M47670
Pathway	REACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN	TUBA3D TUBA3E TUBA3C	6.07e-04	46	51	3	M27828
Pathway	REACTOME_SEPARATION_OF_SISTER_CHROMATIDS	STAG1 TUBA3D TUBA3E TUBA3C KNL1	6.14e-04	191	51	5	M29614
Pathway	KEGG_MEDICUS_VARIANT_TEL_AML1_FUSION_TO_TRANSCRIPTIONAL_REPRESSION	MPO GZMB	6.91e-04	11	51	2	M47438
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	TUBA3D TUBA3E TUBA3C	7.31e-04	49	51	3	M891
Pathway	REACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION	TUBA3D TUBA3E TUBA3C	8.22e-04	51	51	3	M26972
Pathway	REACTOME_MITOTIC_PROMETAPHASE	STAG1 TUBA3D TUBA3E TUBA3C KNL1	8.27e-04	204	51	5	M4217
Pathway	REACTOME_COPI_INDEPENDENT_GOLGI_TO_ER_RETROGRADE_TRAFFIC	TUBA3D TUBA3E TUBA3C	9.20e-04	53	51	3	M27651
Pathway	REACTOME_L1CAM_INTERACTIONS	TUBA3D NFASC TUBA3E TUBA3C	9.45e-04	121	51	4	M872
Pathway	WP_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	TUBA3D TUBA3E TUBA3C	1.03e-03	55	51	3	M39613
Pathway	KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	TUBA3D TUBA3E TUBA3C	1.08e-03	56	51	3	M2333
Pathway	REACTOME_HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND	TUBA3D TUBA3E TUBA3C	1.14e-03	57	51	3	M27251
Pathway	REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT	SLC22A1 SLC22A11	1.31e-03	15	51	2	M888
Pathway	REACTOME_KINESINS	TUBA3D TUBA3E TUBA3C	1.38e-03	61	51	3	M977
Pathway	REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE	STAG1 TUBA3D TUBA3E TUBA3C KNL1	1.58e-03	236	51	5	M27185
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	TUBA3D TUBA3E TUBA3C KNL1	1.62e-03	140	51	4	M27550
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	CHD9 PPARA	1.89e-03	18	51	2	MM15034
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	CHD9 PPARA	1.89e-03	18	51	2	M26942
Pathway	WP_PARKINUBIQUITIN_PROTEASOMAL_SYSTEM_PATHWAY	TUBA3D TUBA3E TUBA3C	2.14e-03	71	51	3	M39690
Pathway	REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY	TUBA3D TUBA3E TUBA3C	2.60e-03	76	51	3	M27215
Pathway	REACTOME_PKR_MEDIATED_SIGNALING	TUBA3D TUBA3E TUBA3C	2.60e-03	76	51	3	M48037
Pathway	REACTOME_THE_ROLE_OF_GTSE1_IN_G2_M_PROGRESSION_AFTER_G2_CHECKPOINT	TUBA3D TUBA3E TUBA3C	2.91e-03	79	51	3	M27743
Pathway	REACTOME_MISCELLANEOUS_TRANSPORT_AND_BINDING_EVENTS	LRRC8E TUSC3	3.65e-03	25	51	2	MM15172
Pubmed	Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity.	TUBA3D TUBA3E HUWE1 TUBA3C	1.39e-09	9	65	4	21167302
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 SMG8 HK2 GTF3C1 DHX57 ERGIC2 ECT2 JMJD1C RGS3	3.31e-06	650	65	9	38777146
Pubmed	Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice.	PPARA HUWE1	3.44e-06	2	65	2	36933792
Pubmed	Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion.	HK2 HUWE1	3.44e-06	2	65	2	31201299
Pubmed	Dual regulation of notch1 signaling pathway by adaptor protein fe65.	APBB1 NOTCH1	3.44e-06	2	65	2	22199353
Pubmed	Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.	GZMB GZMM	3.44e-06	2	65	2	32282833
Pubmed	HIV-1 Tat protein enhances microtubule polymerization.	TUBA3D TUBA3E TUBA3C	5.91e-06	19	65	3	15691386
Pubmed	HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?	TUBA3D TUBA3E TUBA3C	5.91e-06	19	65	3	15698476
Pubmed	Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.	TUBA3D TUBA3E TUBA3C	9.35e-06	22	65	3	23826228
Pubmed	F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.	TUBA3D TUBA3E TUBA3C	9.35e-06	22	65	3	28117675
Pubmed	Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1.	PPARA HUWE1	1.03e-05	3	65	2	29331071
Pubmed	The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.	MPO PPARA	1.03e-05	3	65	2	16956579
Pubmed	PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα.	PPARA HUWE1	1.03e-05	3	65	2	34474167
Pubmed	Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.	GZMB GZMM	1.03e-05	3	65	2	15494398
Pubmed	Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis.	MPO HFE	1.03e-05	3	65	2	15885363
Pubmed	Do genetic variations in antioxidant enzymes influence the course of hereditary hemochromatosis?	MPO HFE	1.03e-05	3	65	2	20673159
Pubmed	Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction.	APBB1 NOTCH1	2.06e-05	4	65	2	17368826
Pubmed	RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.	NOTCH1 KDM1A	2.06e-05	4	65	2	29030483
Pubmed	Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.	APBB1 NOTCH1	2.06e-05	4	65	2	15044485
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	HK2 GTF3C1 STAG1 WDR55 HUWE1 ECT2 JMJD1C NOTCH1 KDM1A	2.99e-05	857	65	9	25609649
Pubmed	STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.	STAG1 STAG3	3.43e-05	5	65	2	12034751
Pubmed	Functional analysis of granzyme M and its role in immunity to infection.	GZMB GZMM	3.43e-05	5	65	2	16116214
Pubmed	SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.	GZMB GZMM	3.43e-05	5	65	2	15454490
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	VPS13D GTF3C1 PIK3C2B CHD9 DHX57 SPG11 KDM1A	3.97e-05	497	65	7	36774506
Pubmed	Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.	SLC22A1 SLC22A11	5.13e-05	6	65	2	11907186
Pubmed	The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development.	NOTCH1 KDM1A	5.13e-05	6	65	2	27112428
Pubmed	Cryo-EM structure of the human cohesin-NIPBL-DNA complex.	STAG1 STAG3	5.13e-05	6	65	2	32409525
Pubmed	Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.	GZMB GZMM	5.13e-05	6	65	2	25526309
Pubmed	PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.	CHD9 PPARA	7.18e-05	7	65	2	16554032
Pubmed	NK cell intrinsic regulation of MIP-1α by granzyme M.	GZMB GZMM	9.56e-05	8	65	2	24625974
Pubmed	LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity.	NOTCH1 KDM1A	9.56e-05	8	65	2	31152129
Pubmed	Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.	HK2 PPARA	9.56e-05	8	65	2	34857752
Pubmed	PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.	MPO CSF2RA	9.56e-05	8	65	2	8777716
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	VPS13D HK2 APBB1 FTSJ1 USP54 HUWE1 VPS51	1.37e-04	606	65	7	36538041
Pubmed	RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.	STAG1 STAG3	1.53e-04	10	65	2	21242291
Pubmed	Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.	GZMB NOTCH1	1.53e-04	10	65	2	16798735
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	GTF3C1 STAG1 STAG3 RGS3 ZNF654	1.59e-04	272	65	5	31010829
Pubmed	A role for granzyme M in TLR4-driven inflammation and endotoxicosis.	GZMB GZMM	2.65e-04	13	65	2	20585036
Pubmed	Murine Models of Acute Alcoholic Hepatitis and Their Relevance to Human Disease.	HFE PPARA	3.08e-04	14	65	2	26835538
Pubmed	Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.	MPO SMG8	3.08e-04	14	65	2	23620142
Pubmed	HIV-host interactome revealed directly from infected cells.	TUSC3 ERGIC2 HUWE1 NOTCH1	3.09e-04	172	65	4	27375898
Pubmed	Germline genomic variants associated with childhood acute lymphoblastic leukemia.	DDC RYR2	3.56e-04	15	65	2	19684603
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	CHD9 JMJD1C NOTCH1 KDM1A	3.91e-04	183	65	4	36129980
Pubmed	Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos.	MPO CSF2RA	4.06e-04	16	65	2	15914564
Pubmed	Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.	GZMB GZMM	4.06e-04	16	65	2	24487434
Pubmed	A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).	MPO HFE PPARA	4.62e-04	80	65	3	19420105
Pubmed	STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.	STAG1 STAG3	6.39e-04	20	65	2	24797475
Pubmed	Discovery and refinement of loci associated with lipid levels.	HFE SLC22A1 PPARA JMJD1C	6.67e-04	211	65	4	24097068
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	HUWE1 NOTCH1	7.06e-04	21	65	2	19686682
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	STAG1 HUWE1 VPS51 ECT2 KDM1A KNL1	7.66e-04	582	65	6	20467437
Pubmed	Functional proteomics mapping of a human signaling pathway.	STAG1 TUSC3 HUWE1 RGS3 RYR2 KNL1	8.29e-04	591	65	6	15231748
Pubmed	Proteomic dissection of the von Hippel-Lindau (VHL) interactome.	TUBA3D TUBA3E TUBA3C	8.35e-04	98	65	3	21942715
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MPO UBR1 SMG8 HK2 GTF3C1 DHX57 HUWE1 ECT2 KDM1A	8.94e-04	1353	65	9	29467282
Pubmed	Overview of PDEs and their regulation.	PDE6C PDE8B	1.00e-03	25	65	2	17307970
Pubmed	Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.	IGDCC3 NOTCH1	1.00e-03	25	65	2	15857914
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	GTF3C1 HUWE1 JMJD1C KDM1A KNL1	1.12e-03	418	65	5	34709266
Pubmed	Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.	HK2 PPARA	1.17e-03	27	65	2	24086110
Pubmed	Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.	VWDE RYR2	1.26e-03	28	65	2	23006423
Pubmed	Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.	MPO HFE PPARA	1.32e-03	115	65	3	20485444
Pubmed	Viral immune modulators perturb the human molecular network by common and unique strategies.	TUBA3E PLP2 TUBA3C	1.36e-03	116	65	3	22810585
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	MPO GTF3C1 STAG1 TUBA3E ERGIC2 ECT2 KDM1A KNL1	1.36e-03	1155	65	8	20360068
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMG8 GTF3C1 USP54 HUWE1 KDM1A	1.40e-03	440	65	5	34244565
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	JMJD1C KDM1A	1.45e-03	30	65	2	26593974
Pubmed	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	STAG1 JMJD1C	1.45e-03	30	65	2	19936222
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	TUBA3D KIAA1755 FTSJ1 DCSTAMP DDC STAG3	1.62e-03	674	65	6	37196079
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	PPARA RGS3	1.65e-03	32	65	2	19320717
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	GTF3C1 DHX57 ECT2 KDM1A RYR2	1.74e-03	462	65	5	31138677
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	GTF3C1 TUSC3 TBCK NFASC CHD9 PPARA HUWE1 ECHDC2 JMJD1C	1.74e-03	1489	65	9	28611215
Pubmed	A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.	HFE JMJD1C	1.86e-03	34	65	2	19820697
Pubmed	A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation.	FTSJ1 PLP2	1.86e-03	34	65	2	10857745
Interaction	IGFBP4 interactions	HK2 VWDE NOTCH1 KDM1A	8.57e-06	41	64	4	int:IGFBP4
Interaction	APBA1 interactions	UBR1 APBB1 ECT2 TUBA3C NOTCH1	1.90e-05	103	64	5	int:APBA1
Cytoband	16p12	GTF3C1 AQP8	1.78e-04	14	65	2	16p12
GeneFamily	Tubulins	TUBA3D TUBA3E TUBA3C	2.15e-05	26	38	3	778
GeneFamily	Cohesin complex	STAG1 STAG3	1.19e-04	8	38	2	1060
GeneFamily	PHD finger proteins\|Lysine demethylases	JMJD1C KDM1A	1.15e-03	24	38	2	485
GeneFamily	Phosphodiesterases	PDE6C PDE8B	1.15e-03	24	38	2	681
Coexpression	HE_LIM_SUN_FETAL_LUNG_C7_MFNG_POS_DBH_POS_NEURON_CELL	NFASC DDC VWDE	9.21e-06	17	64	3	M45795
Coexpression	GSE23568_CTRL_VS_ID3_TRANSDUCED_CD8_TCELL_DN	HK2 GZMB WDR55 ECT2 PLP2 DDC	9.23e-06	199	64	6	M8507
Coexpression	MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED	LRRC8E ASZ1 KIAA1755 TUBA3C	5.91e-05	86	64	4	M1968
Coexpression	MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED	LRRC8E ASZ1 TUBA3D KIAA1755	8.02e-05	93	64	4	MM1266
Coexpression	GSE29618_PRE_VS_DAY7_FLU_VACCINE_BCELL_DN	SLC22A11 DHX57 FTSJ1 OSGIN2 RGS3	1.18e-04	196	64	5	M4973
Coexpression	GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP	TBCK CHD9 SPG11 PPARA KNL1	1.18e-04	196	64	5	M8443
Coexpression	GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_DN	STAG1 CHD9 SPG11 PPARA CARS2	1.21e-04	197	64	5	M8271
Coexpression	GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_DN	STAG1 TUSC3 OSGIN2 KDM1A KNL1	1.24e-04	198	64	5	M6033
Coexpression	GSE22886_IGG_IGA_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_UP	CSF2RA PDE8B HUWE1 ECHDC2 STAG3	1.27e-04	199	64	5	M4444
Coexpression	GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_DN	STAG1 OSGIN2 PLP2 JMJD1C NOTCH1	1.27e-04	199	64	5	M4310
Coexpression	GOLDRATH_NAIVE_VS_EFF_CD8_TCELL_DN	GZMB GZMM VPS51 ECT2 PLP2	1.30e-04	200	64	5	M3036
Coexpression	GSE16450_CTRL_VS_IFNA_6H_STIM_IMMATURE_NEURON_CELL_LINE_UP	HFE UBR1 RALGAPA2 NOTCH1 MOG	1.30e-04	200	64	5	M7417
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGDCC3 CTXN3 ECHDC2 ZNF654	4.96e-05	138	65	4	6b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCell	Adult-Immune-enucleated_erythrocyte-D175\|Adult / Lineage, Cell type, age group and donor	NT5DC4 WDR55 RSPO4 DCSTAMP	7.22e-05	152	65	4	530d5427d8617dcb223d807b73abee0ef89285f3
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLC22A1 GZMB USP54 ECT2	7.99e-05	156	65	4	fc8b8aef29d6d1c0f0c1d08280d8aaff8d30535e
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB GZMM DDC RGS3	8.60e-05	159	65	4	94bc6ab248a8f02ccbc0facd24e0c7e9fda687d2
ToppCell	FLU-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	HFE GZMB ZNF654 KNL1	8.60e-05	159	65	4	97c8e16a7ac10ebba96daee97f9fb1d4a404f23b
ToppCell	FLU-Healthy-1\|FLU / Virus stimulation, Condition and Cluster	HFE GZMB ZNF654 KNL1	8.60e-05	159	65	4	fe2a9f79b058e89214256e736f6e266830cdfa28
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB NFASC RGS3	8.81e-05	160	65	4	955acb023ce4ccfac5073c9d693db87db3856187
ToppCell	tumor_Lung-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	GTF3C1 GZMB GZMM AQP8	9.69e-05	164	65	4	60fe6bb86afaebd92590135f08f5434ce0d8d73c
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 CSF2RA AQP8 DCSTAMP	9.92e-05	165	65	4	2477b0f1a0ea26184cf3cc4a9ffcdfa825cbc615
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE8B NFASC CTXN3 ECHDC2	1.06e-04	168	65	4	e40a3f85be7e9bb23bfbc1f9cb5e5fc54bb43863
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE8B NFASC CTXN3 ECHDC2	1.06e-04	168	65	4	b1d6c35a5ae69c8638afd68c2be5bc9ce6fd2659
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HFE CSF2RA DCSTAMP PLP2	1.09e-04	169	65	4	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HFE HK2 CSF2RA KNL1	1.11e-04	170	65	4	9e94fa0d05abed3438b28296a293767096d517d6
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CSF2RA USP54 OSGIN2 KNL1	1.11e-04	170	65	4	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HFE HK2 CSF2RA PLP2	1.14e-04	171	65	4	0385d5834ae16bbb0c6a68893fec60e4dd1e478d
ToppCell	PND14-Immune-Immune_Myeloid-DC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HFE HK2 CSF2RA KNL1	1.14e-04	171	65	4	8772d6349db24de47f089df2032a80345db7177f
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HFE HK2 CSF2RA PLP2	1.14e-04	171	65	4	a3e3fe0cbab21abb178c482f5951e576529f7e30
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HFE CSF2RA DCSTAMP PLP2	1.14e-04	171	65	4	38a05b5ec8ef8f09a2399994c6b4b9a707918ec1
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	PIK3C2B SPNS2 RGS3 NOTCH1	1.22e-04	174	65	4	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAG1 CHD9 JMJD1C RYR2	1.27e-04	176	65	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	facs-Spleen-nan-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB GZMM RGS3 NOTCH1	1.30e-04	177	65	4	0d894a14ddbb2734557743e9efdb89cee5c26769
ToppCell	3'_v3-Lung-Myeloid_Monocytic-Cycling_mono\|Lung / Manually curated celltypes from each tissue	MPO USP54 MAP10 ECT2	1.33e-04	178	65	4	67aa17b17da3121c199af45e747c23e2626a9bb2
ToppCell	10x5'v1-week_12-13-Lymphocytic_T-T_NK-CD8_T_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GZMM APBB1 DDC STAG3	1.39e-04	180	65	4	5273aa2b939b5c640d708d6ca1812550dff5ec0f
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC22A1 GZMB GZMM RYR2	1.45e-04	182	65	4	c4a7007c864a9455a7e7447e28ccd380878a6a0f
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B2\|356C / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	1.45e-04	182	65	4	52baef8173df0a55307c375674a37c2488066738
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC22A1 GZMB GZMM RYR2	1.45e-04	182	65	4	c315d820ffad912c014ba5eac6f5fa6de1a94384
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO ECT2 STAG3 KNL1	1.45e-04	182	65	4	11494a66d986297b837332ee9d382b71b9f22591
ToppCell	Control-immature_Neutrophil-\|Control / Disease condition and Cell class	MPO ECT2 RGS3 KNL1	1.51e-04	184	65	4	c4e8ba82a6aa76c46f05a71d5f1c7926555318cf
ToppCell	Control-immature_Neutrophil\|Control / Disease condition and Cell class	MPO ECT2 RGS3 KNL1	1.51e-04	184	65	4	2fdae5c6b3eb2232881d933a8c1061fda3623016
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PIK3C2B SPNS2 TUSC3 RALGAPA2	1.51e-04	184	65	4	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A11 KIAA1755 PPARA RGS3	1.57e-04	186	65	4	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIK3C2B SPNS2 CHD9 RGS3	1.60e-04	187	65	4	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIK3C2B SPNS2 CHD9 RGS3	1.60e-04	187	65	4	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PIK3C2B SPNS2 RGS3 NOTCH1	1.64e-04	188	65	4	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	control-immature_Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MPO HFE HK2 VWDE	1.67e-04	189	65	4	bdfd120900ba58d5e54765f7b576e1f8cc2401bf
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMM ECHDC2 ECT2 KNL1	1.71e-04	190	65	4	b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCell	COVID-19-Endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PIK3C2B SPNS2 TUSC3 RALGAPA2	1.71e-04	190	65	4	9fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCell	wk_20-22-Hematologic_Lymphocytic-NK-Cycling_NK\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	GZMB GZMM ECT2 KNL1	1.74e-04	191	65	4	5d4fed25bd318472a17228b12ade4c331865bda5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A11 KIAA1755 CTXN3 DDC	1.78e-04	192	65	4	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIK3C2B SPNS2 RALGAPA2 NOTCH1	1.81e-04	193	65	4	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GTF3C1 GZMB GZMM KNL1	1.85e-04	194	65	4	8bfd7c5be518b81b17913139bcb3ebea01f48dd5
ToppCell	lymphoid-NK_cell-NK_cell\|World / Lineage, cell class and subclass	GTF3C1 GZMB GZMM RGS3	1.85e-04	194	65	4	7f5adc18e632109694446b8eb1543cbae62dccbe
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	1.85e-04	194	65	4	a8dc3336aa4ef497f6d26cede02ddac425e7c655
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD8-Tem/emra_CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	GTF3C1 GZMB GZMM TUBA3C	1.85e-04	194	65	4	ecdfc27d06e363fb23f0309f26ef6404a89f14ec
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GTF3C1 GZMB GZMM KNL1	1.85e-04	194	65	4	f0707601883b234ed477c7704ca9a88efaefc3fd
ToppCell	lymphoid-NK_cell\|World / Lineage, cell class and subclass	GTF3C1 GZMB GZMM RGS3	1.85e-04	194	65	4	4bf5a140be8691e4ec99d7ee15588fd48acd6fb5
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GTF3C1 GZMB GZMM RGS3	1.85e-04	194	65	4	ae5357e2a276473cde1fc8c43acaf9f69da35fd7
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GTF3C1 GZMB GZMM RGS3	1.85e-04	194	65	4	3a0b8b5d0354c43da57bb951cd8ba878363c3de5
ToppCell	IIF-Lymphocyte-T_NK-NK\|IIF / Disease, Lineage and Cell Type	GTF3C1 GZMB GZMM RGS3	1.88e-04	195	65	4	464ce05cb52f78aee22d3baa6641b37bd53aae16
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 GZMB GZMM RGS3	1.88e-04	195	65	4	acc603dc94ac6518adb0dffb43305b380ec75b52
ToppCell	T/NK_cells-CD56dim_NK_cell\|World / Lineage and Cell class	GTF3C1 GZMB GZMM RGS3	1.88e-04	195	65	4	6124e87cb9061bf8918377fb4a79084079ddfc16
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B SPNS2 RGS3 NOTCH1	1.88e-04	195	65	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 STAG1 CHD9 JMJD1C	1.88e-04	195	65	4	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	normal-na-Lymphocytic_NK\|normal / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 GZMB GZMM RGS3	1.88e-04	195	65	4	cebe79c42af5910353ba9ad7d0edb01982f772a3
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	5b5cf6f70534661d694f47359b6595b4580876c3
ToppCell	10x5'-Liver-Lymphocytic_NK-NK_CD16\|Liver / Manually curated celltypes from each tissue	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	e6d4853ccefbcd45a019cee595811f0474dcc036
ToppCell	normal-na-Lymphocytic_NK-NK_dim-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	61bc0d161e01f36e5bcda4d4f4693afbfe5654bb
ToppCell	lymphoid-NK_cell\|lymphoid / Lineage, cell class and subclass	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	0c7fb03ef782256f61624afc5c1bfaed9f1005fb
ToppCell	Fetal_29-31_weeks-Endothelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIK3C2B SPNS2 RALGAPA2 NOTCH1	1.92e-04	196	65	4	3981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCell	lymphoid-NK_cell-NK_cell\|lymphoid / Lineage, cell class and subclass	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	5e6238fe131e349013c60a73c99f84a6be7955ef
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	c25f90c4e5abfe7cfaa85bfe136c438a5179c978
ToppCell	(1)_T_cells-(1)_T_CD8_CytT\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	3a4ba9ca84ce6b35038765da8c55812587b58bc2
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	d451f279f4086fcf727af712f98923551181c76e
ToppCell	normal-na-Lymphocytic_NK-NK_dim\|normal / PBMC cell types (v2) per disease, treatment status, and sex	GTF3C1 GZMB GZMM RGS3	1.92e-04	196	65	4	3360d96dc06241498995bcb875615bd4c1424f5a
ToppCell	356C-Lymphocytic-NK_cells\|356C / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	1.96e-04	197	65	4	ae55ac5c714e55061d605dee030cbe29b43cf9c1
ToppCell	tumor_Lung-T/NK_cells-NK\|T/NK_cells / Location, Cell class and cell subclass	GTF3C1 GZMB GZMM RGS3	1.96e-04	197	65	4	e9fac2c923179b2b8b0500076421c6fb09960b56
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	1.96e-04	197	65	4	d2f7ba404a0340e12ccbd3f9d76c8d782584e775
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	1.96e-04	197	65	4	c7cd7960e8f022b1db49485ff153675827efa35e
ToppCell	cycling_basal_cell\|World / shred by cell class for bronchial biopsy	ECT2 PLP2 NOTCH1 KNL1	2.00e-04	198	65	4	d5306121a75c5eb37d62c353799a98e6ba5ab63f
ToppCell	mild_COVID-19_(asymptomatic)-NK\|World / disease group, cell group and cell class (v2)	GTF3C1 GZMB GZMM RGS3	2.00e-04	198	65	4	7a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B\|356C / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	2.00e-04	198	65	4	0bf7a339e9ee384f1a198ca7c1c51b9a54a7b99f
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-NK\|Multiple_Sclerosis / Disease, Lineage and Cell Type	GTF3C1 GZMB GZMM RGS3	2.00e-04	198	65	4	d413020012977eb8da0a5641dd16d0b0a60bec38
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ASZ1 IGDCC3 MYO15A ECT2	2.00e-04	198	65	4	d5e125f0c4f41b47d567568d0838adcca7655f6d
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GZMB GZMM PLP2 KNL1	2.04e-04	199	65	4	75f221c99adaa29f45dbe365f638b8b123eea148
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	b03539908131308d7bf5036e78c4c840a6a79a17
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GZMB GZMM PLP2 KNL1	2.04e-04	199	65	4	ef767641b669eb2ef3461e51548f4dd09292de90
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	4820f5bcd7bc34c2ebf6a3422cc8eb383a3b5a4e
ToppCell	356C-Lymphocytic-NK_cells\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	9c196c3d8260379d3c9711179e0a913ac9906438
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-gd_T\|Leuk-UTI / Disease, condition lineage and cell class	GTF3C1 SPNS2 GZMB GZMM	2.04e-04	199	65	4	b2c1b9ee764e1246bfa3ecf666ca76ae4ac6c362
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	eb05ccae5187e4701bbbe6d714a6d2808fbcf306
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	10c8729b779073c3bf808e85958d59147f0be5c5
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	867fd292f3879982422e840e087bfdb3b21a8715
ToppCell	Healthy/Control-NK\|Healthy/Control / Disease group and Cell class	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	e7fd91080fca7c31a2d48433791da3c2a4adf14d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	7d071c88a003babf6dbdb84dde561fc03c92f375
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	5e9fe852a70546c9d235414a2c26ca3e67ba6eb9
ToppCell	Control-Lymphoid_T/NK-NK\|Control / Disease group, lineage and cell class	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	94b2693a8378b9b2c58c6aebb2c6658d75b2e3de
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	c3ee60602bdb166a5e67ba1c884dba88b934dfe1
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	d2c9fb69e5ef75778a1652da293fcf8cfa7ecfcc
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A\|356C / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 GZMB GZMM RGS3	2.04e-04	199	65	4	868412bbd8a203f3e9369fb6dc09791c07023496
ToppCell	MS-IIF-Lymphocyte-T/NK-NK\|IIF / Disease, condition lineage and cell class	GTF3C1 GZMB GZMM RGS3	2.08e-04	200	65	4	4f889cc5ab76a128fd781d927b0d8368f4f927b7
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-gd_T\|ICU-NoSEP / Disease, condition lineage and cell class	GTF3C1 GZMB GZMM ERGIC2	2.08e-04	200	65	4	2c2cea7691c340912f6ad77667a580a071eaeb8b
ToppCell	Control-Control-Lymphocyte-T/NK-NK\|Control / Disease, condition lineage and cell class	GTF3C1 GZMB GZMM RGS3	2.08e-04	200	65	4	c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK\|COVID-19_Mild / Disease, condition lineage and cell class	GTF3C1 GZMB GZMM RGS3	2.08e-04	200	65	4	885fcb6c6c744f89fc983a617303e6f57126d908
ToppCell	mild-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GTF3C1 GZMB GZMM RGS3	2.08e-04	200	65	4	a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-NK\|Multiple_Sclerosis / Disease, condition lineage and cell class	GTF3C1 GZMB GZMM RGS3	2.08e-04	200	65	4	d7a611d88107d84b5995b353e8cf95c6a7eb79de
Disease	microlissencephaly (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	5.15e-07	8	63	3	DOID:0112234 (implicated_via_orthology)
Disease	lissencephaly 3 (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	5.15e-07	8	63	3	DOID:0112232 (implicated_via_orthology)
Disease	polymicrogyria (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	5.15e-07	8	63	3	DOID:0080918 (implicated_via_orthology)
Disease	lissencephaly (implicated_via_orthology)	TUBA3D TUBA3E TUBA3C	2.62e-05	27	63	3	DOID:0050453 (implicated_via_orthology)
Disease	Alzheimer's disease 1 (is_implicated_in)	MPO HFE	2.68e-05	4	63	2	DOID:0080348 (is_implicated_in)
Disease	testosterone measurement	HFE UBR1 STAG1 PDE8B SPNS2 SLC22A11 PPARA MYO15A JMJD1C ZNF654 KNL1	7.32e-05	1275	63	11	EFO_0004908
Disease	Experimental Autoimmune Encephalomyelitis	PPARA MOG	1.60e-04	9	63	2	C0014072
Disease	Ischemic stroke, fibrinogen measurement	STAG1 CHD9 JMJD1C	2.25e-04	55	63	3	EFO_0004623, HP_0002140
Disease	Mental Retardation, X-Linked Nonsyndromic	FTSJ1 HUWE1	3.45e-04	13	63	2	C3501611
Disease	serum hepcidin measurement	HFE KIAA1755	6.71e-04	18	63	2	EFO_0004504
Disease	cardiovascular system disease (is_implicated_in)	MPO UBR1	9.18e-04	21	63	2	DOID:1287 (is_implicated_in)
Disease	myeloperoxidase measurement	MPO SMG8	1.41e-03	26	63	2	EFO_0005243
Disease	cystic fibrosis (is_implicated_in)	MPO HFE	1.52e-03	27	63	2	DOID:1485 (is_implicated_in)
Disease	acute kidney failure (implicated_via_orthology)	MPO SLC22A1	1.52e-03	27	63	2	DOID:3021 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLFIFLGILIVRCFR	CTXN3	36	Q4LDR2
GKFIVEIICCRFRLG	ERGIC2	336	Q96RQ1
LKRCGGFLIRDDFVL	GZMB	46	P10144
LVCGKGRVLARVLSF	GZMM	211	P51124
LGECRVRFLSFLAVG	APBB1	601	O00213
VGLLIRCFIGDGKTR	AQP8	241	O94778
CVEVILGLVCFRLKG	DDC	401	P20711
LKRTAITICGFGFLL	ASZ1	451	Q8WWH4
TRGCFDLAQKRIFGL	RGS3	1156	P49796
LCFTGFRKKEELVRL	ECT2	181	Q9H8V3
IRVGGKVTCFLREDL	PCDHB1	376	Q9Y5F3
LLFFVGCGVLLSRKR	NOTCH1	1746	P46531
VLFLLFGQRGRVLLC	IGDCC3	656	Q8IVU1
VIRFGRGKSCLFRLQ	MAP10	86	Q9P2G4
ALTLQRCLRGFFIKR	MYO15A	1906	Q9UKN7
IGALGVKVFRSRIAC	KIAA1755	566	Q5JYT7
RAELVGKRFLCVAVG	JMJD1C	6	Q15652
LGVALAKELIFTGRR	ECHDC2	181	Q86YB7
NILIDFTKRGLLFRG	HK2	756	P52789
LACIIGTQFRKLRDG	MPO	661	P05164
LTEHGLIKCGIRLFF	PDE6C	516	P51160
LGLKVFSRFGVCEFL	PDE8B	576	O95263
FILLVFLSCGLREGR	DCSTAMP	81	Q9H295
VFKDKVRRCSLGIFL	KNL1	1666	Q8NG31
EELFFCRKLRTLLLG	LRRC8E	716	Q6NSJ5
FIGILFIILRKRQGS	HFE	321	Q30201
NSIKIRCEGIRLFLL	RALGAPA2	121	Q2PPJ7
RALAELFGLLVKLCV	HUWE1	1061	Q7Z6Z7
VGLIFLCLQYRLRGK	MOG	171	Q16653
RTRKGILLFAEIILC	PLP2	21	Q04941
FNFRQVLTCGRKLLG	PIK3C2B	741	O00750
ILLIVCFIKRSRGGK	NFASC	1231	O94856
FVNRSLALGKIRCFG	NT5DC4	6	Q86YG4
VRFLKGGALGVTRCL	OSGIN2	471	Q9Y236
RFVFLLCTRAGGLGI	CHD9	1251	Q3L8U1
DVIVGRCLAILKGIF	KDM1A	721	O60341
VRIGKLMLFGSIFRC	DHX57	1066	Q6P158
LQTLRVVFAVLGKGC	SLC22A11	426	Q9NSA0
DRFGRKLCLLGTVLV	SLC22A1	171	O15245
VFRGFFRIICSLLLG	RYR2	4301	Q92736
LVCGIVLGFLFKRFL	CSF2RA	336	P15509
GCKGFFRRTIRLKLV	PPARA	121	Q07869
FTFLILRLPFCGVRI	OR52E5	161	Q8NH55
EICVVGIFGKTALRL	SMG8	46	Q8ND04
RFDIIRRILTKVFGC	CARS2	96	Q9HA77
LFIRREGIRQYGKCL	RSPO4	56	Q2I0M5
LGDRFNRKVILSCGI	SPNS2	161	Q8IVW8
DFECFLLRLSRIGGV	SPG11	956	Q96JI7
LLECVRLRTFGRFGL	VPS51	711	Q9UID3
RIRKLADLCTGLQGF	TUBA3D	121	P0DPH8
RLCLAFLGKRLDSVI	VWDE	821	Q8N2E2
RRIICLVGLGLVVFF	TUSC3	311	Q13454
RRLLAGFCKLLLYGV	STAG3	871	Q9UJ98
RIRKLADLCTGLQGF	TUBA3C	121	P0DPH7
LGCVRIFKRIGFLNK	ZNF654	751	Q8IZM8
GAGVCIFLKIRECRV	UBR1	1661	Q8IWV7
GIKELARRFALTFGL	STAG1	951	Q8WVM7
GIILFELCVGRKLFQ	TBCK	191	Q8TEA7
GCFVAKIFRGRDVTL	FTSJ1	151	Q9UET6
CLGIFNIKRRRFELL	WDR55	191	Q9H6Y2
RIRKLADLCTGLQGF	TUBA3E	121	Q6PEY2
LGKLREELGLCERTF	GTF3C1	276	Q12789
FCEGVKIIFRVGLVL	TBC1D10A	296	Q9BXI6
SLGTCLKLGDLFFRV	USP54	266	Q70EL1
LGKCFFLRVEITLRG	VPS13D	3486	Q5THJ4