Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.74e-30	114	64	20	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.29e-29	124	64	20	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.92e-28	137	64	20	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.26e-25	192	64	20	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	7.71e-15	654	64	20	GO:0008233
GeneOntologyMolecularFunction	protein phosphatase activator activity	PPP4R3C PPP4R3A	1.33e-03	17	64	2	GO:0072542
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH11	1.50e-03	18	64	2	GO:0008569
GeneOntologyMolecularFunction	phosphatase activator activity	PPP4R3C PPP4R3A	1.85e-03	20	64	2	GO:0019211
GeneOntologyMolecularFunction	R-SMAD binding	SMURF1 ZEB2	3.13e-03	26	64	2	GO:0070412
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.06e-29	125	65	20	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	4.19e-28	144	65	20	GO:0070646
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 SMURF1 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.91e-12	1009	65	21	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 SMURF1 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	6.26e-12	1074	65	21	GO:0043687
GeneOntologyBiologicalProcess	melanocyte migration	KIT ZEB2	2.93e-05	3	65	2	GO:0097324
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L7 GDPD1 USP17L21 USP17L4 USP17L2 POMGNT2 USP17L12 USP17L1 USP17L17 USP17L20 ZDHHC6 DNAJC25 USP17L11 SYNE2 USP17L6P USP17L3 USP17L5 TRPM8 USP17L10 APOB RAB1B USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.64e-16	1293	64	27	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L7 GDPD1 USP17L21 USP17L4 USP17L2 POMGNT2 USP17L12 USP17L1 USP17L17 USP17L20 ZDHHC6 DNAJC25 USP17L11 SYNE2 USP17L6P USP17L3 USP17L5 TRPM8 USP17L10 APOB RAB1B USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.84e-16	1299	64	27	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L7 GDPD1 USP17L21 USP17L4 USP17L2 POMGNT2 USP17L12 USP17L1 USP17L17 USP17L20 ZDHHC6 DNAJC25 USP17L11 SYNE2 USP17L6P USP17L3 USP17L5 TRPM8 USP17L10 APOB RAB1B USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.14e-16	1327	64	27	GO:0042175
GeneOntologyCellularComponent	protein phosphatase 4 complex	PPP4R3C PPP4R3A	1.37e-04	6	64	2	GO:0030289
MousePheno	increased trophectoderm apoptosis	USP17L2 USP17L15 USP17L13	1.03e-06	8	38	3	MP:0012119
MousePheno	abnormal embryonic tissue physiology	USP17L2 KAT2A KIT ZEB2 USP17L15 USP17L13 DNAH11	1.31e-05	297	38	7	MP:0008932
MousePheno	increased thymus weight	USP17L2 USP17L15 USP17L13	3.61e-05	24	38	3	MP:0004955
Domain	HABP4_PAI-RBP1	USP17L7 USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	4.84e-34	16	62	14	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L7 USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	4.84e-34	16	62	14	IPR006861
Domain	UCH	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.31e-30	71	62	18	PF00443
Domain	USP_2	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.31e-30	71	62	18	PS00973
Domain	USP_3	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	5.73e-30	72	62	18	PS50235
Domain	USP_dom	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	5.73e-30	72	62	18	IPR028889
Domain	Peptidase_C19_UCH	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	5.73e-30	72	62	18	IPR001394
Domain	USP_CS	USP17L7 USP17L21 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.46e-28	66	62	17	IPR018200
Domain	USP_1	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.52e-28	70	62	17	PS00972
Domain	DHC_N1	DYNC2H1 DNAH11	3.00e-04	8	62	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH11	3.00e-04	8	62	2	IPR013594
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH11	9.62e-04	14	62	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH11	9.62e-04	14	62	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH11	9.62e-04	14	62	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH11	9.62e-04	14	62	2	PF08393
Domain	MT	DYNC2H1 DNAH11	9.62e-04	14	62	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH11	9.62e-04	14	62	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH11	9.62e-04	14	62	2	IPR011704
Domain	AAA_5	DYNC2H1 DNAH11	9.62e-04	14	62	2	PF07728
Domain	DHC_fam	DYNC2H1 DNAH11	1.11e-03	15	62	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH11	1.11e-03	15	62	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH11	1.11e-03	15	62	2	PF03028
Domain	Spectrin	SYNE2 MCF2L	2.62e-03	23	62	2	PF00435
Domain	SH3_2	ZDHHC6 SORBS1 MCF2L	2.93e-03	86	62	3	IPR011511
Domain	SH3_2	ZDHHC6 SORBS1 MCF2L	2.93e-03	86	62	3	PF07653
Domain	-	GDPD1 PLCL2	3.10e-03	25	62	2	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	GDPD1 PLCL2	3.10e-03	25	62	2	IPR017946
Domain	Spectrin_repeat	SYNE2 MCF2L	4.16e-03	29	62	2	IPR002017
Domain	Spectrin/alpha-actinin	SYNE2 MCF2L	5.04e-03	32	62	2	IPR018159
Domain	SPEC	SYNE2 MCF2L	5.04e-03	32	62	2	SM00150
Domain	SH3	ZDHHC6 SORBS1 MCF2L NEB	5.75e-03	216	62	4	SM00326
Domain	SH3_domain	ZDHHC6 SORBS1 MCF2L NEB	6.13e-03	220	62	4	IPR001452
Pathway	REACTOME_RAS_PROCESSING	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.16e-35	45	55	19	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.28e-24	191	55	20	MM15289
Pathway	REACTOME_DEUBIQUITINATION	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P APC USP17L3 USP17L5 USP17L10 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	9.62e-23	262	55	21	MM15286
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	4.01e-21	221	55	19	M27578
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 CNKSR2 USP17L19 USP17L22 KIT USP17L15 USP17L8 USP17L13 USP17L18	5.72e-21	318	55	21	MM15278
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 APC USP17L3 USP17L5 USP17L10 USP17L19 KAT2A USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	4.66e-20	299	55	20	M27574
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L7 USP17L21 USP17L4 USP17L2 POMGNT2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P APC USP17L3 USP17L5 USP17L10 APOB RAB1B USP17L19 KAT2A USP17L22 FBXO21 USP17L15 USP17L8 USP17L13 USP17L18	9.35e-12	1389	55	25	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L4 USP17L2 POMGNT2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 APC USP17L3 USP17L5 USP17L10 APOB RAB1B USP17L19 KAT2A USP17L22 FBXO21 USP17L15 USP17L8 USP17L13 USP17L18	2.48e-10	1475	55	24	M19806
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.64e-51	21	65	19	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.64e-51	21	65	19	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.64e-51	21	65	19	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.64e-51	21	65	19	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.64e-51	21	65	19	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.64e-51	21	65	19	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.20e-50	22	65	19	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.30e-49	24	65	19	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.37e-48	25	65	19	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.09e-48	26	65	19	35816173
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.83e-48	33	65	20	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	20403174
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	14699124
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	11941478
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.41e-47	34	65	20	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.30e-47	35	65	20	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.30e-47	35	65	20	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	7.41e-47	36	65	20	20147298
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.55e-46	29	65	19	32527007
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.61e-46	37	65	20	20228808
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.29e-40	50	65	19	31806660
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	4.27e-21	10	65	8	24207026
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L7 NUTM1 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 CNKSR2 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.18e-20	674	65	21	37196079
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	4.68e-20	12	65	8	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	2.83e-19	14	65	8	11793228
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	7.08e-18	19	65	8	28067227
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	2.75e-12	81	65	8	12838346
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	2.71e-09	119	65	7	28625976
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L2 USP17L15 USP17L13	2.49e-08	4	65	3	22984479
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L7 USP17L4 USP17L1 USP17L3 USP17L8	3.14e-08	48	65	5	16421571
Pubmed	Chromosomal mapping of two members of the human dynein gene family to chromosome regions 7p15 and 11q13 near the deafness loci DFNA 5 and DFNA 11.	DYNC2H1 DNAH11	3.44e-06	2	65	2	9325061
Pubmed	A protective role of mast cells in intestinal tumorigenesis.	APC KIT	3.44e-06	2	65	2	18258601
Pubmed	IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors.	APC IFNAR1	3.44e-06	2	65	2	17671179
Pubmed	Dendritic cells modulate c-kit expression on the edge between activation and death.	KIT IFNAR1	3.44e-06	2	65	2	30758056
Pubmed	Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils.	KIT IFNAR1	1.03e-05	3	65	2	26066745
Pubmed	IDO1+ Paneth cells promote immune escape of colorectal cancer.	APC IFNAR1	2.06e-05	4	65	2	32444775
Pubmed	The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.	APC KIT	2.06e-05	4	65	2	29422500
Pubmed	Mast cells are an essential hematopoietic component for polyp development.	APC KIT	2.06e-05	4	65	2	18077429
Pubmed	MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.	MAP9 APC	2.06e-05	4	65	2	31662330
Pubmed	Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells.	ELF3 ZEB2	2.06e-05	4	65	2	28247944
Pubmed	Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance.	KIT IFNAR1	3.43e-05	5	65	2	15914553
Pubmed	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.	BCL9L APC	3.43e-05	5	65	2	30760710
Pubmed	Genetic and molecular control of folate-homocysteine metabolism in mutant mice.	APC APOB	5.13e-05	6	65	2	12016514
Pubmed	The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.	KIT ZEB2	5.13e-05	6	65	2	21355089
Pubmed	Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin.	TUBGCP2 PPP4R3A	5.13e-05	6	65	2	23966160
Pubmed	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.	BCL9L APC	5.13e-05	6	65	2	30760720
Pubmed	Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells.	ZEB2 IFNAR1	5.13e-05	6	65	2	33773107
Pubmed	Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.	WDR19 DYNC2H1 DNAH11	5.86e-05	40	65	3	32317081
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP17L7 USP17L2 DYNC2H1 EIF3L APC MIOS CNKSR2 KAT2A TUBGCP2	1.02e-04	1005	65	9	19615732
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLCL2 SMURF1 CNKSR2 SORBS1 MCF2L ZEB2	1.14e-04	407	65	6	12693553
Pubmed	SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse.	APC ZEB2	1.87e-04	11	65	2	24243579
Pubmed	The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.	WDR19 DYNC2H1	1.87e-04	11	65	2	22689656
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	WDR19 DYNC2H1 SYNE2 RAB1B MCF2L NEB DNAH11	1.87e-04	638	65	7	31182584
Pubmed	The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.	APC KAT2A	2.65e-04	13	65	2	16510874
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DYNC2H1 DNAH11	2.65e-04	13	65	2	17884984
Pubmed	Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.	KIT IFNAR1	2.65e-04	13	65	2	18480244
Pubmed	A targeted mutation of Nkd1 impairs mouse spermatogenesis.	APC KIT	3.08e-04	14	65	2	15546883
Pubmed	Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.	APC IFNAR1	3.08e-04	14	65	2	27716507
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH11	3.08e-04	14	65	2	9373155
Pubmed	A high-resolution molecular atlas of the fetal mouse lower urogenital tract.	ELF3 KIT ZEB2	3.82e-04	75	65	3	21905163
Pubmed	Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system.	APC ZEB2	4.06e-04	16	65	2	22365546
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SIN3B SYNE2 APC MIOS SPATA20 CNKSR2 SORBS1 ZEB2	4.20e-04	963	65	8	28671696
Pubmed	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	ZDHHC6 TRPM8 SORBS1	4.29e-04	78	65	3	23793025
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	DYNC2H1 DNAH11	4.59e-04	17	65	2	22357932
Pubmed	A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo.	APC KIT	5.16e-04	18	65	2	28494873
Pubmed	The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.	KAT2A KIT	5.16e-04	18	65	2	23637336
Pubmed	Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort.	SMURF1 APC	5.16e-04	18	65	2	20844743
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	SMURF1 FBXO21	5.76e-04	19	65	2	21572392
Pubmed	GATOR2 complex-mediated amino acid signaling regulates brain myelination.	APC MIOS	6.39e-04	20	65	2	35022234
Pubmed	An Alternative Splicing Program for Mouse Craniofacial Development.	SYNE2 SORBS1	7.06e-04	21	65	2	33013468
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	DYNC2H1 DNAH11	1.00e-03	25	65	2	27340223
Pubmed	Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.	NUTM1 NEB	1.09e-03	26	65	2	23892084
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	EIF3L TUBGCP2	1.26e-03	28	65	2	29653964
Pubmed	Maternal DNA Methylation Regulates Early Trophoblast Development.	PTPRE ZEB2	1.26e-03	28	65	2	26812015
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	SYNE2 EIF3L TUBGCP2 SNX29	1.27e-03	251	65	4	29778605
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	WDR19 SIN3B MCF2L	1.36e-03	116	65	3	30652415
Pubmed	Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.	KIT ZEB2	1.65e-03	32	65	2	16516881
Pubmed	Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor.	APC ZEB2	1.65e-03	32	65	2	27806288
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	BCL9L APC	1.86e-03	34	65	2	30894540
Pubmed	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	APOB DNAH11	1.86e-03	34	65	2	19060911
Interaction	FLT3 interactions	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 APOB USP17L19 USP17L18	3.88e-06	318	59	8	int:FLT3
Cytoband	4p16.1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.35e-26	79	65	14	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.24e-19	222	65	14	chr4p16
Cytoband	8p23.1	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	9.06e-08	154	65	6	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.06e-06	234	65	6	chr8p23
Coexpression	MADAN_DPPA4_TARGETS	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.85e-33	86	64	19	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 GBE1 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.16e-32	112	64	20	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.94e-27	160	64	19	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	6.81e-16	647	64	19	MM981
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L7 USP17L21 SIN3B USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 SMURF1 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.82e-13	1198	64	21	MM1062
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 GIMAP5 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.11e-13	1072	64	20	MM1031
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 ELF3 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.93e-12	1226	64	20	MM979
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#4_top-relative-expression-ranked_500	GDPD1 SYNE2 NEB KIT	2.37e-05	81	44	4	gudmap_developingGonad_e18.5_ovary_500_k4
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP251 DYNC2H1 SYNE2 ELF3 DNAH11	5.52e-06	195	58	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CFAP251 DYNC2H1 SYNE2 ELF3 DNAH11	5.52e-06	195	58	5	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP251 DYNC2H1 SYNE2 ELF3 DNAH11	5.52e-06	195	58	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PCYOX1L SPATA20 SORBS1 KIT	5.10e-05	156	58	4	8790b4b400695571fcf1ccb24c658b5e90854ff7
ToppCell	NS-critical-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MAP9 CFAP251 DYNC2H1 DNAH11	8.14e-05	176	58	4	b794275fdd757b8fa2108e3c867f23da2649146d
ToppCell	BAL-Mild-cDC_3\|Mild / Compartment, Disease Groups and Clusters	MAP9 PCYOX1L ELF3 KAT2A	8.14e-05	176	58	4	f9b0c3ced391e7ebe6b242d3f12ba14741f88d22
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SYNE2 SORBS1 MCF2L KIT	8.88e-05	180	58	4	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	droplet-Marrow-nan-3m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCYOX1L KAT2A KIT ZEB2	9.47e-05	183	58	4	92ef926e6c1de8477fa4f35d1dae85482d8009de
ToppCell	droplet-Marrow-nan-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCYOX1L KAT2A KIT ZEB2	9.47e-05	183	58	4	24db9cc717e651586317c6a8e03a3401651273c1
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOB CNKSR2 NEB DNAH11	9.67e-05	184	58	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOB CNKSR2 NEB DNAH11	9.67e-05	184	58	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOB CNKSR2 NEB DNAH11	9.67e-05	184	58	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CCDC82 GIMAP5 PLCL2 SNX29	1.03e-04	187	58	4	c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NIBAN1 SORBS1 ZEB2 DNAH11	1.09e-04	190	58	4	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NIBAN1 SORBS1 ZEB2 DNAH11	1.14e-04	192	58	4	24e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAP9 CFAP251 DYNC2H1 DNAH11	1.16e-04	193	58	4	e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NIBAN1 SYNE2 SORBS1 MCF2L	1.16e-04	193	58	4	5260ac95a15cc43a19909badad0c7e3854da920d
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NIBAN1 SYNE2 SORBS1 MCF2L	1.16e-04	193	58	4	5ec917931b438dd0e7fb03eb6af459d3ef6b84ba
ToppCell	facs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCYOX1L POMGNT2 KAT2A KIT	1.19e-04	194	58	4	c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CFAP251 DYNC2H1 ELF3 DNAH11	1.19e-04	194	58	4	958e648138676d46698090b4046cb484083ae449
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-LZ_GC_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NIBAN1 CFAP251 SYNE2 SNX29	1.21e-04	195	58	4	cccc9c70bb8f6df8c6ab94534c17475af1d3e224
ToppCell	COVID-19_Mild-PLT_5\|COVID-19_Mild / Disease Group and Platelet Clusters	GIMAP5 SYNE2 KAT2A TUBGCP2	1.21e-04	195	58	4	bdf9a6ea1bd83c72a834c45f86ce3f4643a9bef3
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP251 SYNE2 ELF3 DNAH11	1.23e-04	196	58	4	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP251 SYNE2 ELF3 DNAH11	1.23e-04	196	58	4	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	CFAP251 DYNC2H1 ELF3 DNAH11	1.23e-04	196	58	4	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP251 DYNC2H1 SYNE2 DNAH11	1.26e-04	197	58	4	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Bronchial_Brush-Epithelial\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 SYNE2 ELF3 DNAH11	1.26e-04	197	58	4	272c7f4e582ef57564450540242b0db766b78328
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP9 CFAP251 DYNC2H1 DNAH11	1.26e-04	197	58	4	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP9 CFAP251 DYNC2H1 DNAH11	1.26e-04	197	58	4	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NIBAN1 PTPRE SYNE2 ZEB2	1.28e-04	198	58	4	faeef749a4b4bdc7f3edb6923e0e248e8b92c9d0
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP9 CFAP251 DYNC2H1 DNAH11	1.28e-04	198	58	4	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	lymphoid-NK_cell-NK_cell\|NK_cell / Lineage, cell class and subclass	PTPRE SYNE2 ZEB2 PPP4R3A	1.31e-04	199	58	4	945fbf5845403a8b22d04963f50ad69c414b6153
ToppCell	Biopsy_IPF-Epithelial-Differentiating_Ciliated\|Biopsy_IPF / Sample group, Lineage and Cell type	CFAP251 DYNC2H1 ELF3 DNAH11	1.33e-04	200	58	4	8dfce65e417d6dcacb871d93d1539cdf807002fe
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	WDR19 DNAJC25 PLCL2 ZNF75D	1.33e-04	200	58	4	6b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCell	Biopsy_IPF-Epithelial\|Biopsy_IPF / Sample group, Lineage and Cell type	MAP9 DYNC2H1 ELF3 DNAH11	1.33e-04	200	58	4	76f1ac00b34d07057d8da03d276438b719b46b1d
Drug	S(-)-terguride hydrogen maleate [37686-85-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	KCNE2 APC ZNF75D ELF3 CNKSR2 TUBGCP2 MCF2L	2.55e-07	199	50	7	4633_UP
Drug	Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; PC3; HT_HG-U133A	NIBAN1 PTPRE ELF3 MCF2L KIT	4.40e-05	178	50	5	2048_UP
Drug	Advicor	SYNE2 APOB	4.71e-05	5	50	2	CID000151176
Drug	Phenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; PC3; HT_HG-U133A	APC ELF3 SORBS1 MCF2L IFNAR1	6.46e-05	193	50	5	6699_DN
Drug	Carbachol [51-83-2]; Up 200; 21.8uM; MCF7; HT_HG-U133A	SMURF1 APC SORBS1 MCF2L NEB	6.62e-05	194	50	5	5342_UP
Drug	Sulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A	DYNC2H1 SMURF1 ZNF75D MCF2L PPP4R3A	6.78e-05	195	50	5	3409_DN
Drug	Thiocolchicoside [602-41-5]; Down 200; 7uM; MCF7; HT_HG-U133A	WDR19 MAP9 NEB PPP4R3A IFNAR1	6.78e-05	195	50	5	5520_DN
Drug	Metampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; PC3; HT_HG-U133A	MAP9 APC CNKSR2 SORBS1 TUBGCP2	6.78e-05	195	50	5	5115_UP
Drug	Sulfadiazine [68-35-9]; Down 200; 16uM; MCF7; HT_HG-U133A	MAP9 DYNC2H1 SMURF1 ELF3 PPP4R3A	6.95e-05	196	50	5	5523_DN
Drug	dibromosulphthalein	APOB MCF2L	7.05e-05	6	50	2	CID000086995
Drug	Scoulerine [6451-73-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	DYNC2H1 SMURF1 APC NEB PPP4R3A	7.12e-05	197	50	5	5536_DN
Drug	Bupivacaine hydrochloride [18010-40-7]; Down 200; 12.4uM; MCF7; HT_HG-U133A	WDR19 SMURF1 APC KAT2A PPP4R3A	7.29e-05	198	50	5	5537_DN
Drug	5286656; Down 200; 50uM; MCF7; HT_HG-U133A_EA	MAP9 DYNC2H1 ELF3 TUBGCP2 MCF2L	7.29e-05	198	50	5	889_DN
Drug	Aminophylline [317-34-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	PLCL2 APC CNKSR2 TUBGCP2 FBXO21	7.47e-05	199	50	5	6295_UP
Drug	Domperidone maleate; Down 200; 7.4uM; MCF7; HT_HG-U133A	PTPRE SMURF1 APC TUBGCP2 NEB	7.47e-05	199	50	5	5701_DN
Drug	Ondansetron Hydrochloride [103639-04-9]; Down 200; 12.2uM; MCF7; HT_HG-U133A	MAP9 PTPRE SMURF1 ZNF75D MCF2L	7.65e-05	200	50	5	6270_DN
Drug	Todralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A	SMURF1 APC TUBGCP2 PPP4R3A IFNAR1	7.65e-05	200	50	5	5512_DN
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.04e-42	46	64	20	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.07e-38	69	64	20	DOID:1682 (implicated_via_orthology)
Disease	Jeune thoracic dystrophy	WDR19 DYNC2H1	2.77e-05	4	64	2	cv:C0265275
Disease	coronary artery disease, factor VII measurement	KCNE2 DYNC2H1 APOB MCF2L	1.01e-04	111	64	4	EFO_0001645, EFO_0004619
Disease	migraine disorder	KCNE2 ZDHHC6 TRPM8 CNKSR2 SORBS1 ZEB2	1.25e-04	357	64	6	MONDO_0005277
Disease	Jeune thoracic dystrophy	WDR19 DYNC2H1	2.52e-04	11	64	2	C0265275
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	KCNE2 DYNC2H1 APOB	3.52e-04	63	64	3	EFO_0001645, EFO_0004792
Disease	gallbladder cancer (is_implicated_in)	APC APOB	3.56e-04	13	64	2	DOID:3121 (is_implicated_in)
Disease	tissue plasminogen activator measurement, coronary artery disease	KCNE2 DYNC2H1 APOB	5.01e-04	71	64	3	EFO_0001645, EFO_0004791
Disease	Lipidemias	APC APOB	6.17e-04	17	64	2	C1706412
Disease	Hyperlipidemia	APC APOB	6.17e-04	17	64	2	C0020473
Disease	myocardial infarction	KCNE2 DYNC2H1 PLCL2 APOB ZEB2	9.81e-04	350	64	5	EFO_0000612
Disease	proprotein convertase subtilisin/kexin type 9 measurement	APOB CNKSR2	1.04e-03	22	64	2	EFO_0009312
Disease	Coronary heart disease	APOB DNAH11	1.24e-03	24	64	2	C0010068
Disease	Dyslipidemias	APOB DNAH11	1.24e-03	24	64	2	C0242339
Disease	Dyslipoproteinemias	APOB DNAH11	1.24e-03	24	64	2	C0598784
Disease	migraine disorder, pulse pressure measurement	KCNE2 DYNC2H1	1.46e-03	26	64	2	EFO_0005763, MONDO_0005277
Disease	Ciliopathies	WDR19 DYNC2H1 DNAH11	1.78e-03	110	64	3	C4277690
Disease	Mental deterioration	DNAH11 IFNAR1	1.81e-03	29	64	2	HP_0001268
Disease	factor VIII measurement, coronary artery disease	KCNE2 DYNC2H1 APOB	1.92e-03	113	64	3	EFO_0001645, EFO_0004630
Disease	colorectal cancer (implicated_via_orthology)	APC RAB1B	1.94e-03	30	64	2	DOID:9256 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YVEYFIEQVLSWQNK	DNAH11	1511	Q96DT5
QVLDWISYQVEKNKY	ELF3	71	P78545
KVWNYENKQYLFSRV	CFAP251	631	Q8TBY9
YANVKQWLQEIDRYA	RAB1B	96	Q9H0U4
QAEDVATYKVNYTRW	KAT2A	281	Q92830
IENYWKALEDVDYVQ	PPP4R3A	621	Q6IN85
TDYVNWLEEYKVRQK	FBXO21	91	O94952
TEVQEREQDKCYQYW	PTPRE	526	P23469
AAVYQEWLEKKNVYL	MAP9	426	Q49MG5
QWKVVEEINGNNYVY	KIT	556	P10721
QKVYEIQDIYENSWT	EIF3L	86	Q9Y262
EVSVQNQNYVLKWDY	IFNAR1	236	P17181
YNRWYQDLDKIDQKD	PCYOX1L	471	Q8NBM8
INIEQLWRDYNKYEE	CSTF3	181	Q12996
KERIQEDYNDKYWDQ	TUBGCP2	416	Q9BSJ2
YIWVLNEEQEYKRAF	GDPD1	276	Q8N9F7
QYIVEDWQEKYKSQI	KCNE2	86	Q9Y6J6
KYEVWLQEQGENTYV	POMGNT2	521	Q8NAT1
ISKDVYENFRQWQRY	NUTM1	206	Q86Y26
YSVKVYVLNEDEEWN	PPP4R3C	6	Q6ZMV5
DYRQYQAKVEWQVEK	GIMAP5	241	Q96F15
RELWIKENYEVYKQE	DNAJC25	311	Q9H1X3
IYYQELEKFKARWDQ	DYNC2H1	1046	Q8NCM8
SRWKEQYKERVENYS	CCDC82	396	Q8N4S0
YQEWKDKAQNLYQEL	APOB	4141	P04114
AKYVVREGDNVNYDW	GBE1	161	Q04446
EQVAWRKLQEEYYEE	BCL9L	516	Q86UU0
KFEIWYNAREEVYIV	MCF2L	911	O15068
HVYQVYIRIKDDEWN	SNX29	676	Q8TEQ0
LQEWKIYDQLYDEVN	SYNE2	5276	Q8WXH0
KEFQVSFQVQKYWEV	PLCL2	631	Q9UPR0
QGFNKIWREQYEKAY	SIN3B	586	O75182
YKEAVVAYENAKQWQ	WDR19	911	Q8NEZ3
EENKKEYVRLYVNWR	SMURF1	581	Q9HCE7
EEKEKDWYYAQLQNL	APC	151	P25054
YAERERIKQEQDYWS	CNKSR2	671	Q8WXI2
WIEEKAKDRIQYYQL	ZDHHC6	241	Q9H6R6
QAYVLFYIQKSEWER	USP17L3	366	A6NCW0
QAYVLFYIQKSEWER	USP17L4	366	A6NCW7
DVLKDERVQYWIENY	MIOS	686	Q9NXC5
WKERYVVVKNDYAVE	NIBAN1	86	Q9BZQ8
KEGAYYVWTVKEVQQ	SPATA20	396	Q8TB22
KGDIVYIYKQIDQNW	SORBS1	816	Q9BX66
QAYVLFYIQKSEWER	USP17L18	366	D6R9N7
QAYVLFYIQKSEWER	USP17L5	366	A8MUK1
QAYVLFYIQKSEWER	USP17L21	366	D6R901
QAYVLFYIQKSEWER	USP17L13	366	C9JLJ4
QAYVLFYIQKSEWER	USP17L19	366	D6RCP7
QAYVLFYIQKSEWER	USP17L1	366	Q7RTZ2
QAYVLFYIQKSEWER	USP17L12	366	C9JPN9
VFQKEYWNTYRVLQE	ZNF75D	171	P51815
QAYVLFYIQKSEWER	USP17L24	366	Q0WX57
QAYVLFYIQKSEWER	USP17L7	366	P0C7H9
QAYVLFYIQKSEWER	USP17L8	366	P0C7I0
QAYVLFYIQKSEWER	USP17L6P	366	Q6QN14
DQVWKFQRYFLVQEY	TRPM8	991	Q7Z2W7
EFVKEWFEQRKVYQY	ZEB2	686	O60315
QAYVLFYIQKSEWER	USP17L22	366	D6RA61
QAYVLFYIQKSEWER	USP17L15	366	C9J2P7
QAYVLFYIQKSEWER	USP17L17	366	D6RBQ6
QAYVLFYIQKSEWER	USP17L2	366	Q6R6M4
QAYVLFYIQKSEWER	USP17L20	366	D6RJB6
QAYVLFYIQKSEWER	USP17L10	366	C9JJH3
QAYVLFYIQKSEWER	USP17L11	366	C9JVI0
RIQSDNEYKQDYNEW	NEB	2161	P20929