Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dopamine neurotransmitter receptor activity, coupled via Gs	DRD1 DRD5	4.75e-06	2	44	2	GO:0001588
GeneOntologyMolecularFunction	kinase binding	PHYHIP ACSL3 GRB14 NBEA LRRC14 LRBA SPRED2 SPDYE2B POLA1 SPDYE6 SPDYE2	5.83e-06	969	44	11	GO:0019900
GeneOntologyMolecularFunction	palmitoyl-CoA ligase activity	ACSL3 ACSL4	1.42e-05	3	44	2	GO:0090433
GeneOntologyMolecularFunction	protein kinase binding	PHYHIP ACSL3 GRB14 NBEA LRBA SPRED2 SPDYE2B POLA1 SPDYE6 SPDYE2	1.55e-05	873	44	10	GO:0019901
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE2B SPDYE6 SPDYE2	2.81e-05	27	44	3	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE2B SPDYE6 SPDYE2	3.15e-05	28	44	3	GO:0099602
GeneOntologyMolecularFunction	dopamine neurotransmitter receptor activity	DRD1 DRD5	4.73e-05	5	44	2	GO:0004952
GeneOntologyMolecularFunction	dopamine binding	DRD1 DRD5	9.90e-05	7	44	2	GO:0035240
GeneOntologyMolecularFunction	arachidonate-CoA ligase activity	ACSL3 ACSL4	2.58e-04	11	44	2	GO:0047676
GeneOntologyMolecularFunction	catecholamine binding	DRD1 DRD5	3.64e-04	13	44	2	GO:1901338
GeneOntologyMolecularFunction	long-chain fatty acid-CoA ligase activity	ACSL3 ACSL4	4.89e-04	15	44	2	GO:0004467
GeneOntologyMolecularFunction	neurotransmitter receptor activity	DRD1 DRD5 HTR6	1.39e-03	100	44	3	GO:0030594
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSL3 ACSL4	1.49e-03	26	44	2	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSL3 ACSL4	1.61e-03	27	44	2	GO:0016405
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSL3 ACSL4	2.12e-03	31	44	2	GO:0016878
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	ACSL3 ACSL4	3.68e-03	41	44	2	GO:0016877
GeneOntologyMolecularFunction	G-protein alpha-subunit binding	DRD1 DRD5	4.05e-03	43	44	2	GO:0001965
GeneOntologyMolecularFunction	protein kinase A binding	NBEA LRBA	7.25e-03	58	44	2	GO:0051018
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE2B SPDYE6 SPDYE2	2.16e-05	25	45	3	GO:0045737
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein kinase activity	SPDYE2B SPDYE6 SPDYE2	3.06e-05	28	45	3	GO:1904031
GeneOntologyBiologicalProcess	sensitization	DRD1 DRD5	4.63e-05	5	45	2	GO:0046960
GeneOntologyBiologicalProcess	phospholipase C-activating dopamine receptor signaling pathway	DRD1 DRD5	1.66e-04	9	45	2	GO:0060158
Domain	Speedy	SPDYE2B SPDYE6 SPDYE2	1.99e-06	11	44	3	IPR020984
Domain	Spy1	SPDYE2B SPDYE6 SPDYE2	1.99e-06	11	44	3	PF11357
Domain	DUF1088	NBEA LRBA	5.42e-06	2	44	2	PF06469
Domain	DUF1088	NBEA LRBA	5.42e-06	2	44	2	IPR010508
Domain	Dopamine_rcpt	DRD1 DRD5	5.40e-05	5	44	2	IPR000929
Domain	DUF4704	NBEA LRBA	5.40e-05	5	44	2	PF15787
Domain	DUF4704	NBEA LRBA	5.40e-05	5	44	2	IPR031570
Domain	PH_BEACH	NBEA LRBA	8.09e-05	6	44	2	PF14844
Domain	Keratin_B2	KRTAP10-1 KRTAP10-2 KRTAP10-5	1.13e-04	40	44	3	PF01500
Domain	PH-BEACH_dom	NBEA LRBA	1.51e-04	8	44	2	IPR023362
Domain	PH_BEACH	NBEA LRBA	1.51e-04	8	44	2	PS51783
Domain	-	NBEA LRBA	1.51e-04	8	44	2	2.30.29.40
Domain	Beach	NBEA LRBA	1.93e-04	9	44	2	PF02138
Domain	-	NBEA LRBA	1.93e-04	9	44	2	1.10.1540.10
Domain	BEACH_dom	NBEA LRBA	1.93e-04	9	44	2	IPR000409
Domain	Beach	NBEA LRBA	1.93e-04	9	44	2	SM01026
Domain	BEACH	NBEA LRBA	1.93e-04	9	44	2	PS50197
Domain	KAP	KRTAP10-1 KRTAP10-2 KRTAP10-5	3.44e-04	58	44	3	IPR002494
Domain	AMP-binding_CS	ACSL3 ACSL4	1.70e-03	26	44	2	IPR020845
Domain	AMP_BINDING	ACSL3 ACSL4	1.97e-03	28	44	2	PS00455
Domain	AMP-binding	ACSL3 ACSL4	2.26e-03	30	44	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSL3 ACSL4	2.26e-03	30	44	2	IPR000873
Domain	7TM_GPCR_Srsx	DRD1 DRD5 HTR6	2.32e-03	112	44	3	SM01381
Domain	WD40	WDR18 NBEA LRBA MED16	3.17e-03	259	44	4	PF00400
Domain	WD40	WDR18 NBEA LRBA MED16	3.59e-03	268	44	4	SM00320
Domain	WD40_repeat	WDR18 NBEA LRBA MED16	3.78e-03	272	44	4	IPR001680
Domain	Keratin_B2_2	KRTAP10-1 KRTAP10-2	3.80e-03	39	44	2	PF13885
Domain	WD_REPEATS_1	WDR18 NBEA LRBA MED16	4.08e-03	278	44	4	PS00678
Domain	WD_REPEATS_2	WDR18 NBEA LRBA MED16	4.14e-03	279	44	4	PS50082
Domain	WD_REPEATS_REGION	WDR18 NBEA LRBA MED16	4.14e-03	279	44	4	PS50294
Domain	WD40_repeat_dom	WDR18 NBEA LRBA MED16	5.16e-03	297	44	4	IPR017986
Domain	-	WDR18 NBEA LRBA MED16	7.69e-03	333	44	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR18 NBEA LRBA MED16	7.85e-03	335	44	4	IPR015943
Pathway	WP_MONOAMINE_GPCRS	DRD1 DRD5 HTR6	4.15e-05	31	31	3	MM15871
Pathway	REACTOME_DOPAMINE_RECEPTORS	DRD1 DRD5	4.66e-05	5	31	2	M27301
Pathway	REACTOME_DOPAMINE_RECEPTORS	DRD1 DRD5	4.66e-05	5	31	2	MM15007
Pathway	WP_MONOAMINE_GPCRS	DRD1 DRD5 HTR6	5.02e-05	33	31	3	M39585
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	DRD1 DRD5 HTR6	1.04e-04	42	31	3	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	DRD1 DRD5 HTR6	1.04e-04	42	31	3	MM14971
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ACSL3 ACSL4 EBP	1.46e-04	47	31	3	M39853
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ACSL3 ACSL4 EBP	1.98e-04	52	31	3	MM15920
Pathway	KEGG_MEDICUS_REFERENCE_BETA_OXIDATION_ACYL_COA_SYNTHESIS	ACSL3 ACSL4	2.54e-04	11	31	2	M47626
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL3 ACSL4	2.54e-04	11	31	2	M27317
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL3 ACSL4	2.54e-04	11	31	2	MM15035
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	4.19e-04	14	31	2	MM15840
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	4.19e-04	14	31	2	M39780
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	4.83e-04	15	31	2	M39789
Pathway	WP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION	ACSL3 ACSL4	5.51e-04	16	31	2	MM15841
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	5.51e-04	16	31	2	MM15813
Pathway	WP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION	ACSL3 ACSL4	6.24e-04	17	31	2	M39365
Pathway	WP_FATTY_ACID_TRANSPORTERS	ACSL3 ACSL4	7.01e-04	18	31	2	M42570
Pathway	WP_MITOCHONDRIAL_FATTY_ACID_OXIDATION_DISORDERS	ACSL3 ACSL4	7.82e-04	19	31	2	M48049
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACSL3 ACSL4	1.05e-03	22	31	2	M39440
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ACSL3 ACSL4	1.05e-03	22	31	2	MM15451
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACSL3 ACSL4	1.15e-03	23	31	2	MM15885
Pathway	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	ACSL3 ACSL4	1.25e-03	24	31	2	M1016
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ACSL3 ACSL4	2.23e-03	32	31	2	MM15446
Pathway	WP_FATTY_ACID_BETAOXIDATION	ACSL3 ACSL4	2.51e-03	34	31	2	M39596
Pathway	WP_FATTY_ACID_BETAOXIDATION	ACSL3 ACSL4	2.51e-03	34	31	2	MM15937
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	ACSL3 ACSL4	2.97e-03	37	31	2	M729
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	DRD1 DRD5 HTR6	3.73e-03	143	31	3	MM15055
Pathway	KEGG_FATTY_ACID_METABOLISM	ACSL3 ACSL4	3.81e-03	42	31	2	M699
Pathway	REACTOME_KERATINIZATION	KRTAP10-1 KRTAP10-2 KRTAP10-5	4.51e-03	153	31	3	MM15343
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	DRD1 DRD5 HTR6	4.85e-03	157	31	3	M4904
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE2B SPDYE6 SPDYE2	1.69e-07	9	45	3	36272447
Pubmed	Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21.	KRTAP10-1 KRTAP10-2 KRTAP10-5	3.32e-07	11	45	3	14962103
Pubmed	Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.	DRD1 DRD5 HTR6	3.32e-07	11	45	3	18855532
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE2B SPDYE6 SPDYE2	5.74e-07	13	45	3	15611625
Pubmed	A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.	KRTAP10-1 KRTAP10-2 KRTAP10-5	1.12e-06	16	45	3	15028290
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE2B SPDYE6 SPDYE2	1.36e-06	17	45	3	15574121
Pubmed	D1/D5 modulation of synaptic NMDA receptor currents.	DRD1 DRD5	1.64e-06	2	45	2	19279248
Pubmed	Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.	DRD1 DRD5	1.64e-06	2	45	2	26186971
Pubmed	Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.	ACSL3 ACSL4	1.64e-06	2	45	2	32286604
Pubmed	The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.	DRD1 DRD5	1.64e-06	2	45	2	21893192
Pubmed	Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors.	DRD1 DRD5	1.64e-06	2	45	2	26763483
Pubmed	Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory.	DRD1 DRD5	1.64e-06	2	45	2	24843151
Pubmed	Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.	DRD1 DRD5	1.64e-06	2	45	2	1831904
Pubmed	Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory.	DRD1 DRD5	1.64e-06	2	45	2	26174222
Pubmed	CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter.	POLA1 CUX1	1.64e-06	2	45	2	12665598
Pubmed	Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity.	DRD1 DRD5	1.64e-06	2	45	2	13679419
Pubmed	PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation.	DRD1 DRD5	1.64e-06	2	45	2	26807952
Pubmed	Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses.	DRD1 DRD5	1.64e-06	2	45	2	25429131
Pubmed	Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates.	DRD1 DRD5	1.64e-06	2	45	2	19204052
Pubmed	Agonist-dependent and -independent dopamine-1-like receptor signalling differentially regulates downstream effectors.	DRD1 DRD5	1.64e-06	2	45	2	25154512
Pubmed	Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.	ACSL3 ACSL4	1.64e-06	2	45	2	28193492
Pubmed	Role of the extracellular amino terminus and first membrane-spanning helix of dopamine D1 and D5 receptors in shaping ligand selectivity and efficacy.	DRD1 DRD5	1.64e-06	2	45	2	19786093
Pubmed	Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice.	DRD1 DRD5	1.64e-06	2	45	2	11823893
Pubmed	Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists.	DRD1 DRD5	1.64e-06	2	45	2	20180564
Pubmed	The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport.	DRD1 DRD5	1.64e-06	2	45	2	24552847
Pubmed	The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.	ACSL3 ACSL4	1.64e-06	2	45	2	29450800
Pubmed	Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase.	DRD1 DRD5	1.64e-06	2	45	2	11500503
Pubmed	Dopamine D₁-like receptors regulate the α₁A-adrenergic receptor in human renal proximal tubule cells and D₁-like dopamine receptor knockout mice.	DRD1 DRD5	4.91e-06	3	45	2	25339698
Pubmed	Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor.	DRD1 DRD5	4.91e-06	3	45	2	18172057
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	4.91e-06	3	45	2	28814779
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE6 SPDYE2	4.91e-06	3	45	2	22763696
Pubmed	Identification of a cyclic adenosine 3',5'-monophosphate-dependent protein kinase phosphorylation site in the carboxy terminal tail of human D1 dopamine receptor.	DRD1 DRD5	4.91e-06	3	45	2	7609904
Pubmed	Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers.	DRD1 DRD5	4.91e-06	3	45	2	19171671
Pubmed	Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.	DRD1 DRD5	4.91e-06	3	45	2	22710646
Pubmed	Dopamine receptor genes and migraine with and without aura: an association study.	DRD1 DRD5	4.91e-06	3	45	2	12047334
Pubmed	Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons.	DRD1 DRD5	4.91e-06	3	45	2	12867509
Pubmed	Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers.	DRD1 DRD5	4.91e-06	3	45	2	21115476
Pubmed	Dopamine genes and pathological gambling in discordant sib-pairs.	DRD1 DRD5	9.81e-06	4	45	2	17394052
Pubmed	Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults.	DRD1 HTR6	9.81e-06	4	45	2	18197272
Pubmed	Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.	DRD1 DRD5	9.81e-06	4	45	2	25049074
Pubmed	Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors.	DRD1 DRD5	9.81e-06	4	45	2	16962565
Pubmed	Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.	DRD1 DRD5	9.81e-06	4	45	2	20164562
Pubmed	Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes.	DRD1 DRD5	9.81e-06	4	45	2	12967601
Pubmed	Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.	DRD1 DRD5	9.81e-06	4	45	2	18403039
Pubmed	Dopamine receptors: from structure to function.	DRD1 DRD5	1.63e-05	5	45	2	9457173
Pubmed	[Dopamine receptor signaling regulates human osteoclastogenesis].	DRD1 DRD5	1.63e-05	5	45	2	23445730
Pubmed	Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.	ACSL3 ACSL4	1.63e-05	5	45	2	15292367
Pubmed	Evidence against dopamine D1/D2 receptor heteromers.	DRD1 DRD5	1.63e-05	5	45	2	25560761
Pubmed	Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes.	DRD1 DRD5	1.63e-05	5	45	2	22219295
Pubmed	Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain.	DRD1 DRD5	1.63e-05	5	45	2	20714340
Pubmed	Upregulation of renal D5 dopamine receptor ameliorates the hypertension in D3 dopamine receptor-deficient mice.	DRD1 DRD5	1.63e-05	5	45	2	23753418
Pubmed	Redundant catecholamine signaling consolidates fear memory via phospholipase C.	DRD1 DRD5	1.63e-05	5	45	2	22323706
Pubmed	The effects of spiritual intervention and changes in dopamine receptor gene expression in breast cancer patients.	DRD1 DRD5	1.63e-05	5	45	2	26597879
Pubmed	Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort.	DRD1 DRD5	1.63e-05	5	45	2	19105202
Pubmed	Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.	DRD1 DRD5	1.63e-05	5	45	2	12509874
Pubmed	BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.	NBEA LRBA	1.63e-05	5	45	2	12160729
Pubmed	Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo.	DRD1 DRD5	1.63e-05	5	45	2	20038975
Pubmed	Dopamine receptor mRNA and protein expression in the mouse corpus striatum and cerebral cortex during pre- and postnatal development.	DRD1 DRD5	1.63e-05	5	45	2	17509542
Pubmed	The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.	ACSL3 ACSL4	1.63e-05	5	45	2	22633490
Pubmed	Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.	DRD1 DRD5	1.63e-05	5	45	2	18083900
Pubmed	Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1.	KRTAP10-1 KRTAP10-2 KRTAP10-5	1.93e-05	40	45	3	12359730
Pubmed	An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.	NBEA LRBA	2.45e-05	6	45	2	19482073
Pubmed	Retinal dopamine mediates multiple dimensions of light-adapted vision.	DRD1 DRD5	2.45e-05	6	45	2	22764243
Pubmed	DISC1 regulates primary cilia that display specific dopamine receptors.	DRD1 DRD5	2.45e-05	6	45	2	20531939
Pubmed	Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.	DRD1 DRD5	2.45e-05	6	45	2	21982372
Pubmed	Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heart.	ACSL3 ACSL4	3.42e-05	7	45	2	17197235
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	NBEA DRD1 DRD5 HTR6 NTS	4.25e-05	300	45	5	19086053
Pubmed	Two-stage case-control association study of dopamine-related genes and migraine.	DRD1 DRD5	5.86e-05	9	45	2	19772578
Pubmed	Confirmation of quantitative trait loci for cocaine-induced activation in the AcB/BcA series of recombinant congenic strains.	DRD1 DRD5	5.86e-05	9	45	2	12777963
Pubmed	Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice.	DRD1 DRD5	5.86e-05	9	45	2	16525059
Pubmed	A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.	DRD1 DRD5 HTR6	5.94e-05	58	45	3	11140838
Pubmed	Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).	DRD1 DRD5	7.32e-05	10	45	2	21083670
Pubmed	Support for association between ADHD and two candidate genes: NET1 and DRD1.	DRD1 DRD5	8.94e-05	11	45	2	15717291
Pubmed	Association study of 182 candidate genes in anorexia nervosa.	DRD1 DRD5 HTR6 NTS	9.14e-05	182	45	4	20468064
Pubmed	Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.	DRD1 DRD5 HTR6	1.04e-04	70	45	3	12036966
Pubmed	Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control.	DRD1 DRD5	1.70e-04	15	45	2	26053317
Pubmed	Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.	ACSL3 ACSL4	2.20e-04	17	45	2	14741744
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	DRD1 DRD5	2.47e-04	18	45	2	8521822
Pubmed	Identification of novel spartin-interactors shows spartin is a multifunctional protein.	ACSL3 ACSL4	2.76e-04	19	45	2	19765186
Pubmed	Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies.	DRD1 DRD5	3.38e-04	21	45	2	18270970
Pubmed	GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.	DNHD1 THADA	4.07e-04	23	45	2	23725790
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	DRD1 DRD5	4.82e-04	25	45	2	28154160
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	DRD1 DRD5 HTR6	4.87e-04	118	45	3	19156168
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	NBEA LRBA	5.63e-04	27	45	2	19723784
Pubmed	Biosynthesis of triacylglycerols.	ACSL3 ACSL4	6.06e-04	28	45	2	8944226
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	GRB14 LRBA SPRED2 POLA1	7.61e-04	318	45	4	16919269
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	DRC7 ACSL3 LRBA CUX1 EBP	8.14e-04	568	45	5	37774976
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	MUC19 APOBEC3G THADA SPRED2	9.96e-04	342	45	4	23128233
Pubmed	Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.	NSUN5P2 CUX1	1.12e-03	38	45	2	11779826
Cytoband	7q22.1	SPDYE2B CUX1 SPDYE6 SPDYE2	4.80e-06	113	45	4	7q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	SPDYE2B CUX1 SPDYE6 SPDYE2	6.44e-05	219	45	4	chr7q22
Cytoband	21q22.3	KRTAP10-1 KRTAP10-2 KRTAP10-5	2.76e-04	128	45	3	21q22.3
Cytoband	1p34.1	KDM4A LRRC41	1.45e-03	57	45	2	1p34.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq23	ACSL4 LHFPL1	3.48e-03	89	45	2	chrXq23
Cytoband	Ensembl 112 genes in cytogenetic band chr21q22	KRTAP10-1 KRTAP10-2 KRTAP10-5	6.04e-03	377	45	3	chr21q22
Cytoband	Ensembl 112 genes in cytogenetic band chr4q31	LRBA ZNF827	1.14e-02	164	45	2	chr4q31
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE2B SPDYE6 SPDYE2	9.94e-07	12	31	3	756
GeneFamily	Dopamine receptors	DRD1 DRD5	2.84e-05	5	31	2	181
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	1.02e-04	9	31	2	1230
GeneFamily	Keratin associated proteins	KRTAP10-1 KRTAP10-2 KRTAP10-5	8.47e-04	109	31	3	619
GeneFamily	Acyl-CoA synthetase family	ACSL3 ACSL4	9.01e-04	26	31	2	40
GeneFamily	WD repeat domain containing	WDR18 NBEA LRBA MED16	9.97e-04	262	31	4	362
Coexpression	MARTINEZ_RESPONSE_TO_TRABECTEDIN	SPIDR LRBA POLA1 CUX1	1.37e-06	50	43	4	M5077
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP	NBEA KDM4A THADA LRBA POLA1	1.74e-05	197	43	5	M7403
CoexpressionAtlas	dev gonad_e13.5_M_DevVasTestis_Flk_k-means-cluster#3_top-relative-expression-ranked_500	ACSL4 TENT5C GRB14 PLXDC1	1.68e-06	45	41	4	gudmap_dev gonad_e13.5_M_gudmap_devVasTestis_Flk_k3_500
Drug	melperone	DRD1 DRD5 HTR6 NTS	4.19e-08	19	43	4	CID000015386
Drug	SB 200646A	DRD1 DRD5 HTR6 NTS	4.19e-08	19	43	4	CID000126769
Drug	setoperone	DRD1 DRD5 HTR6 NTS	7.87e-08	22	43	4	CID000068604
Drug	CI-943	DRD1 DRD5 NTS	1.25e-07	6	43	3	CID000146009
Drug	oxiperomide	DRD1 DRD5 NTS	1.25e-07	6	43	3	CID000068634
Drug	LEK-8829	DRD1 DRD5 NTS	3.49e-07	8	43	3	CID000164460
Drug	iloperidone	DRD1 DRD5 HTR6 NTS	6.22e-07	36	43	4	CID000071360
Drug	spiroxatrine	DRD1 DRD5 HTR6 NTS	1.17e-06	42	43	4	CID000005268
Drug	fluphenazine decanoate	DRD1 DRD5 NTS	2.25e-06	14	43	3	CID000003388
Drug	SCH 23390	DRD1 DRD5 LRBA HTR6 NTS	2.60e-06	116	43	5	CID000005018
Drug	OPC-4392	DRD1 DRD5 HTR6	2.81e-06	15	43	3	CID000163839
Drug	columbamine	DRD1 DRD5	3.48e-06	2	43	2	CID000072309
Drug	dehydrocorybulbine	DRD1 DRD5	3.48e-06	2	43	2	CID005316439
Drug	zelandopam	DRD1 DRD5	3.48e-06	2	43	2	CID003078104
Drug	tetrahydrocolumbamine	DRD1 DRD5	3.48e-06	2	43	2	CID000010220
Drug	spirodecanone	DRD1 DRD5 NTS	5.02e-06	18	43	3	CID000070556
Drug	tiospirone	DRD1 DRD5 HTR6	5.95e-06	19	43	3	CID000055751
Drug	S-20499	DRD1 DRD5 HTR6	5.95e-06	19	43	3	CID000121851
Drug	RP 62203	DRD1 DRD5 HTR6	5.95e-06	19	43	3	CID000060785
Drug	EEDQ	DRD1 DRD5 HTR6 NTS	1.03e-05	72	43	4	CID000027833
Drug	AC1LR3WA	DRD1 DRD5	1.04e-05	3	43	2	CID001361946
Drug	Berupipam	DRD1 DRD5	1.04e-05	3	43	2	CID000066002
Drug	carphenazine	DRD1 DRD5	1.04e-05	3	43	2	CID000018104
Drug	U-99363E	DRD1 DRD5	1.04e-05	3	43	2	CID000133107
Drug	Carphenazine	DRD1 DRD5	1.04e-05	3	43	2	DB01038
Drug	ecopipam	DRD1 DRD5	1.04e-05	3	43	2	ctd:C058081
Drug	phenanthridine	DRD1 DRD5 ISM1	1.08e-05	23	43	3	CID000009189
Drug	Mp2589	DRD1 DRD5 HTR6 NTS	1.22e-05	75	43	4	CID003073497
Drug	N-1-naphthylphthalamic acid	DRD1 DRD5 NTS	1.24e-05	24	43	3	CID000008594
Drug	hydroxamates	DRD1 DRD5 HTR6	1.40e-05	25	43	3	CID000033630
Drug	Olanzapine	DRD1 DRD5 HTR6	1.40e-05	25	43	3	DB00334
Drug	Ziprasidone	DRD1 DRD5 HTR6	1.40e-05	25	43	3	DB00246
Drug	N-n-propylnorapomorphine	DRD1 DRD5 NTS	1.40e-05	25	43	3	CID000030137
Drug	Aripiprazole	DRD1 DRD5 HTR6	1.40e-05	25	43	3	DB01238
Drug	AC1L1JND	DRD1 DRD5 HTR6 NTS	1.49e-05	79	43	4	CID000005118
Drug	tardan	DRD1 DRD5 HTR6	1.58e-05	26	43	3	CID000002729
Drug	Quetiapine	DRD1 DRD5 HTR6	1.58e-05	26	43	3	DB01224
Drug	T15550	DRD1 DRD5 HTR6	1.58e-05	26	43	3	CID000005454
Drug	melanostatin	DRD1 DRD5 NTS	1.58e-05	26	43	3	CID000092910
Drug	ergolines	DRD1 DRD5 HTR6	1.78e-05	27	43	3	CID003083577
Drug	fluperlapine	DRD1 DRD5 HTR6	1.78e-05	27	43	3	CID000049381
Drug	NSC169490	DRD1 DRD5 HTR6	1.78e-05	27	43	3	CID004210613
Drug	AC1L1BOS	DRD1 DRD5 NTS	1.99e-05	28	43	3	CID000051767
Drug	NSC407316	DRD1 DRD5 HTR6	1.99e-05	28	43	3	CID000003067
Drug	dimethocaine	DRD1 DRD5	2.09e-05	4	43	2	CID000007177
Drug	MK-458	DRD1 DRD5	2.09e-05	4	43	2	CID000057532
Drug	SCH 40853	DRD1 DRD5	2.09e-05	4	43	2	CID003035575
Drug	DK-118	DRD1 DRD5	2.09e-05	4	43	2	CID000145953
Drug	U 101958	DRD1 DRD5	2.09e-05	4	43	2	CID005311492
Drug	mianserin	DRD1 DRD5 HTR6 NTS	2.19e-05	87	43	4	CID000004184
Drug	NBQX	DRD1 DRD5 HTR6 NTS	2.50e-05	90	43	4	CID003272523
Drug	desipramine	DRD1 DRD5 HTR6 MED16 NTS	2.72e-05	188	43	5	CID000002995
Drug	mesulergine	DRD1 DRD5 HTR6	2.72e-05	31	43	3	CID000068848
Drug	eticlopride	DRD1 DRD5 NTS	3.00e-05	32	43	3	CID000057266
Drug	SR 48692	DRD1 DRD5 NTS	3.00e-05	32	43	3	CID000119192
Drug	Dihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A	LRRC14 SPIDR MED16 LRRC41 CAPN15	3.16e-05	194	43	5	2793_DN
Drug	pirenperone	DRD1 DRD5 HTR6	3.29e-05	33	43	3	CID000004847
Drug	BMY 14802	DRD1 DRD5 NTS	3.29e-05	33	43	3	CID000108046
Drug	mesoridazine	DRD1 DRD5 HTR6	3.29e-05	33	43	3	CID000004078
Drug	Etanidazole [22668-01-5]; Up 200; 18.6uM; HL60; HT_HG-U133A	TNFRSF12A TENT5C APOBEC3G MED16 LRRC41	3.32e-05	196	43	5	2510_UP
Drug	Dobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	ACSL4 TENT5C LRRC14 SPRED2 CAPN15	3.32e-05	196	43	5	5386_DN
Drug	pargyline	DRD1 DRD5 HTR6 NTS	3.36e-05	97	43	4	CID000004688
Drug	SCH 24518	DRD1 DRD5	3.47e-05	5	43	2	CID000146265
Drug	dimethylphenylphosphine	CUX1 NTS	3.47e-05	5	43	2	CID000069597
Drug	DH97	DRD1 DRD5	3.47e-05	5	43	2	CID003467177
Drug	AMMTC	DRD1 DRD5	3.47e-05	5	43	2	CID005311004
Drug	tilozepine	DRD1 DRD5	3.47e-05	5	43	2	CID000172286
Drug	2-di-n-propylaminoindan	DRD1 DRD5	3.47e-05	5	43	2	CID000130402
Drug	mezilamine	DRD1 DRD5	3.47e-05	5	43	2	CID000068678
Drug	C9H11N3O2	DRD1 DRD5	3.47e-05	5	43	2	CID000123703
Drug	NNC-687	DRD1 DRD5	3.47e-05	5	43	2	CID000164252
Drug	SKF 77434	DRD1 DRD5	3.47e-05	5	43	2	CID000001241
Drug	proterguride	DRD1 DRD5	3.47e-05	5	43	2	CID000071999
Drug	NO 756	DRD1 DRD5	3.47e-05	5	43	2	CID000129967
Drug	Levodopa	DRD1 DRD5	3.47e-05	5	43	2	DB01235
Drug	SKF 82957	DRD1 DRD5	3.47e-05	5	43	2	CID000130844
Drug	SKF85174	DRD1 DRD5	3.47e-05	5	43	2	CID000132435
Drug	corydaline	DRD1 DRD5	3.47e-05	5	43	2	CID000101301
Drug	l-CSL	DRD1 DRD5	3.47e-05	5	43	2	CID006918538
Drug	3-iodobenzamide	DRD1 DRD5	3.47e-05	5	43	2	CID000202425
Drug	dihydrexidine	DRD1 DRD5	3.47e-05	5	43	2	ctd:C061532
Drug	dazopride	DRD1 DRD5	3.47e-05	5	43	2	CID000054801
Drug	Fenoldopam	DRD1 DRD5	3.47e-05	5	43	2	DB00800
Drug	azapride	DRD1 DRD5	3.47e-05	5	43	2	CID003036441
Drug	piquindone	DRD1 DRD5	3.47e-05	5	43	2	CID000121903
Drug	A 68930	DRD1 DRD5	3.47e-05	5	43	2	ctd:C065380
Drug	Drofenine hydrochloride [548-66-3]; Down 200; 11.4uM; HL60; HT_HG-U133A	NBEA SPIDR MED16 CUX1 LRRC41	3.48e-05	198	43	5	2714_DN
Drug	Netilmicin sulfate [56931-57-2]; Down 200; 2.8uM; MCF7; HT_HG-U133A	ACSL4 TENT5C SPRED2 LRRC41 CAPN15	3.65e-05	200	43	5	6005_DN
Drug	5-HTP	DRD1 DRD5 HTR6 NTS	3.94e-05	101	43	4	CID000000144
Drug	AC1L1CXF	DRD1 DRD5 HTR6	4.29e-05	36	43	3	CID000002104
Drug	molindone	DRD1 DRD5 HTR6	4.29e-05	36	43	3	CID000023897
Drug	benzotropine mesylate	DRD1 DRD5 HTR6	4.66e-05	37	43	3	CID000002344
Drug	promazine	DRD1 DRD5 HTR6	4.66e-05	37	43	3	CID000004926
Drug	AC1L1E8W	DRD1 DRD5 LRBA ISM1	4.94e-05	107	43	4	CID000002691
Drug	pipamperone	DRD1 DRD5 HTR6	5.05e-05	38	43	3	CID000004830
Drug	3-methoxytyramine	DRD1 DRD5 NTS	5.05e-05	38	43	3	CID000001669
Drug	2'-ISP	DRD1 DRD5	5.20e-05	6	43	2	CID000128389
Drug	Rotigotine	DRD1 DRD5	5.20e-05	6	43	2	DB05271
Drug	pyrazole-3	DRD1 DRD5	5.20e-05	6	43	2	CID000354929
Drug	Zuclopenthixol	DRD1 DRD5	5.20e-05	6	43	2	DB01624
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	ACSL3 ACSL4 THADA	1.65e-07	9	38	3	DOID:0050776 (implicated_via_orthology)
Disease	non-syndromic X-linked intellectual disability 63 (implicated_via_orthology)	ACSL3 ACSL4	1.61e-06	2	38	2	DOID:0112050 (implicated_via_orthology)
Disease	Sjogren-Larsson syndrome (implicated_via_orthology)	ACSL3 ACSL4	2.41e-05	6	38	2	DOID:14501 (implicated_via_orthology)
Disease	outer ear morphology trait	LRBA CUX1	1.06e-04	12	38	2	EFO_0007664
Disease	lobe attachment	NBEA SPIDR LRBA CUX1	1.44e-04	207	38	4	EFO_0007667
Disease	Waxy flexibility	DRD1 NTS	1.68e-04	15	38	2	C0233612
Disease	Catalepsy	DRD1 NTS	1.68e-04	15	38	2	C0007370
Disease	alanine measurement	ACSL3 TENT5C LRRC14	1.87e-04	86	38	3	EFO_0009765
Disease	mean platelet volume	ACSL3 ACSL4 TENT5C CATSPERB C4BPB POLA1 CUX1	2.85e-04	1020	38	7	EFO_0004584
Disease	depressive disorder (implicated_via_orthology)	DRD1 DRD5	3.67e-04	22	38	2	DOID:1596 (implicated_via_orthology)
Disease	Depressive disorder	ACSL4 DRD1 DRD5 NTS	5.12e-04	289	38	4	C0011581
Disease	Hyperkinesia, Generalized	DRD1 NTS	7.82e-04	32	38	2	C0751217
Disease	Hyperkinesia	DRD1 NTS	7.82e-04	32	38	2	C3887506
Disease	lung cancer (is_marker_for)	ACSL3 KDM4A	1.16e-03	39	38	2	DOID:1324 (is_marker_for)
Disease	Depression, Neurotic	ACSL4 DRD5	1.28e-03	41	38	2	C0282126
Disease	Melancholia	ACSL4 DRD5	1.28e-03	41	38	2	C0025193
Disease	Depressive Syndrome	ACSL4 DRD5	1.35e-03	42	38	2	C0086133
Disease	glucose measurement	TENT5C GRB14 KDM4A THADA	1.41e-03	380	38	4	EFO_0004468
Disease	Endogenous depression	ACSL4 DRD5	1.61e-03	46	38	2	C0011573
Disease	Manic Disorder	DRD1 DRD5	3.79e-03	71	38	2	C0024713
Disease	Amphetamine Abuse	DRD1 HTR6	4.22e-03	75	38	2	C0236807
Disease	Amphetamine Addiction	DRD1 HTR6	4.22e-03	75	38	2	C0236804
Disease	Amphetamine-Related Disorders	DRD1 HTR6	4.22e-03	75	38	2	C0236733
Disease	Unipolar Depression	ACSL4 DRD5 CUX1	4.49e-03	259	38	3	C0041696
Disease	Manic	DRD1 DRD5	4.56e-03	78	38	2	C0338831
Disease	Depression, Bipolar	DRD1 DRD5	4.67e-03	79	38	2	C0005587
Disease	sensory perception of sweet taste	GRB14 KDM4A	5.03e-03	82	38	2	GO_0050916

Protein segments in the cluster

Peptide	Gene	Start	Entry
FCETRAEWMIAAQTC	ACSL4	156	O60488
LWTAFDVMCCSASIL	HTR6	101	P50406
AFIMWSASTECFVTT	CATSPERB	806	Q9H7T0
CFTSWSPCFSCAQEM	APOBEC3G	281	Q9HC16
ASVEAWEAVCNCFMP	DNHD1	2566	Q96M86
CNIWVAFDIMCSTAS	DRD1	96	P21728
AFCDVWVAFDIMCST	DRD5	111	P21918
MTADILSDSWEFCSF	INSYN1	101	Q2T9L4
MATVGEWSCVRCTFL	CAPN15	1	O75808
WSESMERDCATFCAK	CUX1	641	Q13948
MYAEACSAVGVCVSW	MUC19	1516	Q7Z5P9
ASMATLLAWAGVSCC	NSUN5P2	81	Q63ZY6
KASEDWMCSRCSANA	KDM4A	756	O75164
KCDITCQAEVWSMFT	LRBA	101	P50851
AAAAMLICTWLSCFA	LHFPL1	176	Q86WI0
WIESAETHVSCCVMV	POLA1	366	P09884
ACAWSCRNLIAFTMD	MED16	36	Q9Y2X0
AFSSWSLCSDSEEEM	NTS	16	P30990
GMTWCITTCNFDVDV	CCDC93	56	Q567U6
ACCLMVAWRVSASDA	C4BPB	6	P20851
WDSCAQFVSDFLTMV	DRC7	146	Q8IY82
MLCAEEEQSRTCWVT	GRB14	321	Q14449
MSVCSSACSDSWQVD	KRTAP10-1	6	P60331
MSICSSACTNSWQVD	KRTAP10-2	6	P60368
MSVCSSACSDSWRVD	KRTAP10-5	6	P60370
NFTVCMETITACLWG	EBP	116	Q15125
EVDTDSCERWMSCKS	ISM1	291	B1AKI9
VDCTSVPEWFMSSCR	THADA	281	Q6YHU6
SCWFCEVAAATTMEA	LRRC41	11	Q15345
EHCDVTCQAEIWSMF	NBEA	126	Q8NFP9
TCDSFRISWAMEDSD	PHYHIP	16	Q92561
EVAVCTDSAAPMWSC	WDR18	6	Q9BV38
FFCSMSCRAWVSPEE	SPDYE2B	366	A6NHP3
SCTRDCMSFSVLNWD	TENT5C	6	Q5VWP2
CETRAEWMIAAQACF	ACSL3	166	O95573
VDESTAFSWPVCDMC	SPIDR	786	Q14159
FFCSMSCRAWVSPEE	SPDYE2	366	Q495Y8
FFCSMSCRAWVSPEE	SPDYE6	366	P0CI01
MDSWTFCCVSLCILV	TRBV12-3	1	P01733
SCDTSDEKFCLRWMA	SPRED2	366	Q7Z698
DKEQWMFSICCTACD	ZNF827	921	Q17R98
SWSADLDKCMDCASC	TNFRSF12A	41	Q9NP84
DACMSSDLTFNCSWC	PLXDC1	311	Q8IUK5
AAIMVSCCAISWSTV	XKR9	166	Q5GH70
MWDCTAAVARTCIAQ	LRRC14	136	Q15048