Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ErbB-3 class receptor binding	ERBB2 ERBB3	7.89e-06	6	15	2	GO:0043125
GeneOntologyMolecularFunction	glutamate-gated calcium ion channel activity	GRIN2C GRIN2D	1.47e-05	8	15	2	GO:0022849
GeneOntologyMolecularFunction	NMDA glutamate receptor activity	GRIN2C GRIN2D	1.47e-05	8	15	2	GO:0004972
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	6.14e-05	105	15	3	GO:0015171
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIN2C GRIN2D	7.12e-05	17	15	2	GO:0004970
GeneOntologyMolecularFunction	glutamate receptor activity	GRIN2C GRIN2D	1.83e-04	27	15	2	GO:0008066
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	GRIN2C GRIN2D	2.42e-04	31	15	2	GO:0099604
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	4.56e-04	207	15	3	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	4.62e-04	208	15	3	GO:0005342
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIN2C GRIN2D	8.21e-04	57	15	2	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIN2C GRIN2D	9.09e-04	60	15	2	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIN2C GRIN2D	1.07e-03	65	15	2	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIN2C GRIN2D	1.07e-03	65	15	2	GO:0022824
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	ERBB2 ERBB3	1.07e-03	65	15	2	GO:0004714
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	1.25e-03	293	15	3	GO:0008514
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIN2C GRIN2D	1.42e-03	75	15	2	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GRIN2C GRIN2D	1.49e-03	77	15	2	GO:0005230
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	ERBB2 ERBB3	1.81e-03	85	15	2	GO:0019199
GeneOntologyMolecularFunction	transporter activity	ATP10A SLC6A15 SLC2A11 GRIN2C GRIN2D	1.93e-03	1289	15	5	GO:0005215
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ERBB2 ERBB3 OR6C68 GRIN2C GRIN2D	2.40e-03	1353	15	5	GO:0004888
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GRIN2C GRIN2D	2.50e-03	100	15	2	GO:0030594
GeneOntologyMolecularFunction	calcium channel activity	GRIN2C GRIN2D	4.12e-03	129	15	2	GO:0005262
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PIGN ERBB2 ERBB3 MAP3K14	4.36e-03	938	15	4	GO:0016772
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	4.63e-03	465	15	3	GO:0046873
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	GRIN2C GRIN2D	4.83e-03	140	15	2	GO:0099094
GeneOntologyMolecularFunction	protein tyrosine kinase activity	ERBB2 ERBB3	5.17e-03	145	15	2	GO:0004713
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	GRIN2C GRIN2D	5.59e-03	151	15	2	GO:0015085
GeneOntologyMolecularFunction	growth factor binding	ERBB2 ERBB3	5.96e-03	156	15	2	GO:0019838
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	GRIN2C GRIN2D	8.02e-03	182	15	2	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	GRIN2C GRIN2D	8.19e-03	184	15	2	GO:0022832
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GRIN2C GRIN2D	8.98e-03	193	15	2	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GRIN2C GRIN2D	9.34e-03	197	15	2	GO:0022834
GeneOntologyMolecularFunction	protein kinase activity	ERBB2 ERBB3 MAP3K14	9.38e-03	600	15	3	GO:0004672
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A15 SLC2A11 GRIN2C GRIN2D	9.80e-03	1180	15	4	GO:0022857
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	1.06e-02	627	15	3	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	1.24e-02	664	15	3	GO:0008324
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	ERBB2 ERBB3 MAP3K14	1.47e-02	709	15	3	GO:0016773
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	1.76e-02	758	15	3	GO:0015318
GeneOntologyMolecularFunction	kinase activity	ERBB2 ERBB3 MAP3K14	1.80e-02	764	15	3	GO:0016301
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A15 GRIN2C GRIN2D	1.99e-02	793	15	3	GO:0015075
GeneOntologyMolecularFunction	gated channel activity	GRIN2C GRIN2D	2.54e-02	334	15	2	GO:0022836
GeneOntologyMolecularFunction	ubiquitin protein ligase binding	ERBB2 ERBB3	2.58e-02	337	15	2	GO:0031625
GeneOntologyMolecularFunction	monoatomic cation channel activity	GRIN2C GRIN2D	2.67e-02	343	15	2	GO:0005261
GeneOntologyMolecularFunction	ubiquitin-like protein ligase binding	ERBB2 ERBB3	2.89e-02	358	15	2	GO:0044389
GeneOntologyBiologicalProcess	ERBB2-ERBB3 signaling pathway	ERBB2 ERBB3	3.83e-05	13	15	2	GO:0038133
GeneOntologyBiologicalProcess	ERBB3 signaling pathway	ERBB2 ERBB3	4.47e-05	14	15	2	GO:0038129
GeneOntologyBiologicalProcess	excitatory chemical synaptic transmission	GRIN2C GRIN2D	5.89e-05	16	15	2	GO:0098976
GeneOntologyBiologicalProcess	regulation of striated muscle tissue development	ERBB3 CDON	1.47e-04	25	15	2	GO:0016202
GeneOntologyBiologicalProcess	ERBB2 signaling pathway	ERBB2 ERBB3	1.71e-04	27	15	2	GO:0038128
GeneOntologyBiologicalProcess	ionotropic glutamate receptor signaling pathway	GRIN2C GRIN2D	1.71e-04	27	15	2	GO:0035235
GeneOntologyBiologicalProcess	positive regulation of muscle tissue development	ERBB3 CDON	1.98e-04	29	15	2	GO:1901863
GeneOntologyBiologicalProcess	regulation of muscle organ development	ERBB3 CDON	2.27e-04	31	15	2	GO:0048634
GeneOntologyBiologicalProcess	ligand-gated ion channel signaling pathway	GRIN2C GRIN2D	3.79e-04	40	15	2	GO:1990806
GeneOntologyBiologicalProcess	startle response	GRIN2C GRIN2D	3.98e-04	41	15	2	GO:0001964
GeneOntologyBiologicalProcess	positive regulation of synaptic transmission, glutamatergic	GRIN2C GRIN2D	4.38e-04	43	15	2	GO:0051968
GeneOntologyBiologicalProcess	positive regulation of excitatory postsynaptic potential	GRIN2C GRIN2D	4.38e-04	43	15	2	GO:2000463
GeneOntologyBiologicalProcess	Schwann cell development	ERBB2 ERBB3	5.24e-04	47	15	2	GO:0014044
GeneOntologyBiologicalProcess	Schwann cell differentiation	ERBB2 ERBB3	7.17e-04	55	15	2	GO:0014037
GeneOntologyBiologicalProcess	regulation of muscle tissue development	ERBB3 CDON	7.70e-04	57	15	2	GO:1901861
GeneOntologyBiologicalProcess	glutamate receptor signaling pathway	GRIN2C GRIN2D	8.25e-04	59	15	2	GO:0007215
GeneOntologyBiologicalProcess	calcium-mediated signaling	ERBB3 GRIN2C GRIN2D	8.60e-04	266	15	3	GO:0019722
GeneOntologyBiologicalProcess	modulation of excitatory postsynaptic potential	GRIN2C GRIN2D	1.00e-03	65	15	2	GO:0098815
GeneOntologyBiologicalProcess	protein localization to postsynaptic membrane	ERBB2 GRIN2C	1.40e-03	77	15	2	GO:1903539
GeneOntologyBiologicalProcess	protein localization to postsynapse	ERBB2 GRIN2C	1.51e-03	80	15	2	GO:0062237
GeneOntologyBiologicalProcess	regulation of neuronal synaptic plasticity	GRIN2C GRIN2D	1.62e-03	83	15	2	GO:0048168
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	DNMBP ERBB2 CDON	1.64e-03	333	15	3	GO:0051056
GeneOntologyBiologicalProcess	positive regulation of phosphorylation	ERBB2 ERBB3 CDON DYNAP	1.98e-03	780	15	4	GO:0042327
GeneOntologyBiologicalProcess	regulation of synaptic transmission, glutamatergic	GRIN2C GRIN2D	1.99e-03	92	15	2	GO:0051966
GeneOntologyBiologicalProcess	positive regulation of small GTPase mediated signal transduction	ERBB2 CDON	1.99e-03	92	15	2	GO:0051057
GeneOntologyBiologicalProcess	peripheral nervous system development	ERBB2 ERBB3	2.25e-03	98	15	2	GO:0007422
GeneOntologyBiologicalProcess	positive regulation of kinase activity	ERBB2 ERBB3 DYNAP	2.87e-03	405	15	3	GO:0033674
GeneOntologyBiologicalProcess	positive regulation of phosphate metabolic process	ERBB2 ERBB3 CDON DYNAP	3.07e-03	879	15	4	GO:0045937
GeneOntologyBiologicalProcess	positive regulation of phosphorus metabolic process	ERBB2 ERBB3 CDON DYNAP	3.07e-03	879	15	4	GO:0010562
GeneOntologyBiologicalProcess	protein localization to synapse	ERBB2 GRIN2C	3.09e-03	115	15	2	GO:0035418
GeneOntologyCellularComponent	ERBB3:ERBB2 complex	ERBB2 ERBB3	4.81e-07	2	15	2	GO:0038143
GeneOntologyCellularComponent	NMDA selective glutamate receptor complex	GRIN2C GRIN2D	1.73e-05	9	15	2	GO:0017146
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	ERBB2 ERBB3 GRIN2C GRIN2D	9.11e-05	350	15	4	GO:0098802
GeneOntologyCellularComponent	postsynaptic membrane	ERBB2 ERBB3 GRIN2C GRIN2D	1.60e-04	405	15	4	GO:0045211
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	GRIN2C GRIN2D	4.67e-04	45	15	2	GO:0008328
GeneOntologyCellularComponent	neurotransmitter receptor complex	GRIN2C GRIN2D	5.77e-04	50	15	2	GO:0098878
GeneOntologyCellularComponent	receptor complex	ERBB2 ERBB3 GRIN2C GRIN2D	6.31e-04	581	15	4	GO:0043235
GeneOntologyCellularComponent	synaptic membrane	ERBB2 ERBB3 GRIN2C GRIN2D	6.40e-04	583	15	4	GO:0097060
GeneOntologyCellularComponent	plasma membrane protein complex	ERBB2 ERBB3 GRIN2C GRIN2D	1.93e-03	785	15	4	GO:0098797
GeneOntologyCellularComponent	postsynapse	ERBB2 ERBB3 GRIN2C GRIN2D	4.96e-03	1018	15	4	GO:0098794
GeneOntologyCellularComponent	postsynaptic density membrane	GRIN2C GRIN2D	5.52e-03	157	15	2	GO:0098839
GeneOntologyCellularComponent	transporter complex	ATP10A GRIN2C GRIN2D	6.51e-03	550	15	3	GO:1990351
GeneOntologyCellularComponent	postsynaptic specialization membrane	GRIN2C GRIN2D	8.90e-03	201	15	2	GO:0099634
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PIGN ATP10A GRIN2C GRIN2D	1.15e-02	1293	15	4	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PIGN ATP10A GRIN2C GRIN2D	1.17e-02	1299	15	4	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PIGN ATP10A GRIN2C GRIN2D	1.25e-02	1327	15	4	GO:0042175
MousePheno	abnormal Schwann cell precursor morphology	ERBB2 ERBB3	1.38e-06	3	10	2	MP:0004074
MousePheno	decreased Schwann cell precursor number	ERBB2 ERBB3	1.38e-06	3	10	2	MP:0004075
MousePheno	abnormal petrosal ganglion morphology	ERBB2 ERBB3	4.17e-05	14	10	2	MP:0001084
MousePheno	decreased atrioventricular cushion size	ERBB2 ERBB3	7.00e-05	18	10	2	MP:0000301
MousePheno	poor circulation	ERBB2 ERBB3	7.83e-05	19	10	2	MP:0001633
MousePheno	abnormal ventral spinal root morphology	ERBB2 ERBB3	7.83e-05	19	10	2	MP:0003993
MousePheno	abnormal axon fasciculation	ERBB2 ERBB3	1.16e-04	23	10	2	MP:0009450
MousePheno	abnormal glossopharyngeal ganglion morphology	ERBB2 ERBB3	2.26e-04	32	10	2	MP:0001096
MousePheno	abnormal neural crest cell migration	ERBB2 ERBB3	2.55e-04	34	10	2	MP:0002950
MousePheno	abnormal Schwann cell morphology	ERBB2 ERBB3	3.03e-04	37	10	2	MP:0001106
MousePheno	abnormal PNS glial cell morphology	ERBB2 ERBB3	3.03e-04	37	10	2	MP:0001105
MousePheno	abnormal neural crest cell physiology	ERBB2 ERBB3	4.09e-04	43	10	2	MP:0012745
MousePheno	abnormal vagus ganglion morphology	ERBB2 ERBB3	4.49e-04	45	10	2	MP:0001100
MousePheno	holoprosencephaly	PIGN CDON	5.11e-04	48	10	2	MP:0005157
MousePheno	abnormal paravertebral ganglion morphology	ERBB2 ERBB3	5.76e-04	51	10	2	MP:0008317
MousePheno	abnormal trigeminal nerve morphology	ERBB2 ERBB3	5.99e-04	52	10	2	MP:0001065
MousePheno	abnormal trigeminal ganglion morphology	ERBB2 ERBB3	6.70e-04	55	10	2	MP:0001092
MousePheno	abnormal sympathetic ganglion morphology	ERBB2 ERBB3	6.70e-04	55	10	2	MP:0001008
MousePheno	abnormal sympathetic system morphology	ERBB2 ERBB3	8.24e-04	61	10	2	MP:0001007
MousePheno	abnormal atrioventricular cushion morphology	ERBB2 ERBB3	1.28e-03	76	10	2	MP:0000297
MousePheno	abnormal fetal atrioventricular canal morphology	ERBB2 ERBB3	1.45e-03	81	10	2	MP:0006107
MousePheno	abnormal autonomic nervous system morphology	ERBB2 ERBB3	1.74e-03	89	10	2	MP:0002751
MousePheno	abnormal dorsal root ganglion morphology	ERBB2 ERBB3	2.37e-03	104	10	2	MP:0000961
MousePheno	abnormal spinal nerve morphology	ERBB2 ERBB3	2.51e-03	107	10	2	MP:0001077
MousePheno	abnormal vertical activity	DNMBP GRIN2C GRIN2D	3.13e-03	439	10	3	MP:0020167
MousePheno	abnormal mammary gland development	ERBB3 MAP3K14	3.46e-03	126	10	2	MP:0000628
MousePheno	abnormal myocardial trabeculae morphology	ERBB2 ERBB3	4.49e-03	144	10	2	MP:0002189
MousePheno	abnormal motor neuron morphology	ERBB2 ERBB3	4.93e-03	151	10	2	MP:0000937
MousePheno	abnormal midbrain morphology	PIGN ERBB3	4.93e-03	151	10	2	MP:0000897
Domain	Tyr_kinase_EGF/ERB/XmrK_rcpt	ERBB2 ERBB3	3.61e-06	4	15	2	IPR016245
Domain	GF_recep_IV	ERBB2 ERBB3	9.01e-06	6	15	2	PF14843
Domain	GF_recep_IV	ERBB2 ERBB3	9.01e-06	6	15	2	IPR032778
Domain	Furin-like	ERBB2 ERBB3	1.26e-05	7	15	2	PF00757
Domain	Rcpt_L-dom	ERBB2 ERBB3	1.26e-05	7	15	2	IPR000494
Domain	Furin-like_Cys-rich_dom	ERBB2 ERBB3	1.26e-05	7	15	2	IPR006211
Domain	Recep_L_domain	ERBB2 ERBB3	1.26e-05	7	15	2	PF01030
Domain	-	ERBB2 ERBB3	1.26e-05	7	15	2	3.80.20.20
Domain	PBPe	GRIN2C GRIN2D	9.14e-05	18	15	2	SM00079
Domain	Iono_rcpt_met	GRIN2C GRIN2D	9.14e-05	18	15	2	IPR001508
Domain	Glu/Gly-bd	GRIN2C GRIN2D	9.14e-05	18	15	2	IPR019594
Domain	Furin_repeat	ERBB2 ERBB3	9.14e-05	18	15	2	IPR006212
Domain	Iontro_rcpt	GRIN2C GRIN2D	9.14e-05	18	15	2	IPR001320
Domain	Lig_chan	GRIN2C GRIN2D	9.14e-05	18	15	2	PF00060
Domain	FU	ERBB2 ERBB3	9.14e-05	18	15	2	SM00261
Domain	Lig_chan-Glu_bd	GRIN2C GRIN2D	9.14e-05	18	15	2	SM00918
Domain	Lig_chan-Glu_bd	GRIN2C GRIN2D	9.14e-05	18	15	2	PF10613
Domain	ANF_receptor	GRIN2C GRIN2D	3.95e-04	37	15	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIN2C GRIN2D	3.95e-04	37	15	2	IPR001828
Domain	Peripla_BP_I	GRIN2C GRIN2D	4.39e-04	39	15	2	IPR028082
Domain	TyrKc	ERBB2 ERBB3	2.21e-03	88	15	2	SM00219
Domain	Tyr_kinase_cat_dom	ERBB2 ERBB3	2.21e-03	88	15	2	IPR020635
Domain	PROTEIN_KINASE_TYR	ERBB2 ERBB3	2.68e-03	97	15	2	PS00109
Domain	Tyr_kinase_AS	ERBB2 ERBB3	2.68e-03	97	15	2	IPR008266
Domain	Pkinase_Tyr	ERBB2 ERBB3	4.69e-03	129	15	2	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB2 ERBB3	5.34e-03	138	15	2	IPR001245
Domain	PROTEIN_KINASE_ATP	ERBB2 ERBB3 MAP3K14	5.38e-03	459	15	3	PS00107
Domain	Prot_kinase_dom	ERBB2 ERBB3 MAP3K14	6.42e-03	489	15	3	IPR000719
Domain	PROTEIN_KINASE_DOM	ERBB2 ERBB3 MAP3K14	6.56e-03	493	15	3	PS50011
Domain	Growth_fac_rcpt_	ERBB2 ERBB3	6.78e-03	156	15	2	IPR009030
Domain	Kinase-like_dom	ERBB2 ERBB3 MAP3K14	8.52e-03	542	15	3	IPR011009
Domain	L_dom-like	ERBB2 ERBB3	2.78e-02	328	15	2	IPR032675
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	GRIN2C GRIN2D	7.84e-06	5	13	2	MM15655
Pathway	KEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	7.84e-06	5	13	2	M47667
Pathway	REACTOME_GRB7_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB3	7.84e-06	5	13	2	M26937
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	1.18e-05	6	13	2	M47668
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	ERBB2 ERBB3 GRIN2C GRIN2D	1.61e-05	178	13	4	M2890
Pathway	REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING	ERBB2 ERBB3	4.30e-05	11	13	2	MM15478
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_LIGAND_GATED_CA2_CHANNEL	GRIN2C GRIN2D	5.15e-05	12	13	2	M47953
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	ERBB2 ERBB3	5.15e-05	12	13	2	MM14550
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	ERBB2 ERBB3	6.09e-05	13	13	2	M549
Pathway	REACTOME_ERBB2_REGULATES_CELL_MOTILITY	ERBB2 ERBB3	6.09e-05	13	13	2	MM15320
Pathway	REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING	ERBB2 ERBB3	6.09e-05	13	13	2	M27729
Pathway	REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB3	7.10e-05	14	13	2	MM14761
Pathway	REACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB3	7.10e-05	14	13	2	MM14531
Pathway	PID_ERBB_NETWORK_PATHWAY	ERBB2 ERBB3	8.19e-05	15	13	2	M201
Pathway	REACTOME_ERBB2_REGULATES_CELL_MOTILITY	ERBB2 ERBB3	8.19e-05	15	13	2	M27608
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	8.19e-05	15	13	2	M47691
Pathway	REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB3	9.35e-05	16	13	2	M570
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	1.19e-04	18	13	2	M47761
Pathway	WP_NRXN1_DELETION_SYNDROME	GRIN2C GRIN2D	1.19e-04	18	13	2	M48098
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	1.33e-04	19	13	2	M47677
Pathway	BIOCARTA_NOS1_PATHWAY	GRIN2C GRIN2D	1.48e-04	20	13	2	MM1445
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIN2C GRIN2D	1.48e-04	20	13	2	MM15485
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIN2C GRIN2D	1.63e-04	21	13	2	M27736
Pathway	BIOCARTA_NOS1_PATHWAY	GRIN2C GRIN2D	1.63e-04	21	13	2	M11650
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIN2C GRIN2D	1.63e-04	21	13	2	M838
Pathway	REACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION	GRIN2C GRIN2D	1.63e-04	21	13	2	M27944
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIN2C GRIN2D	1.79e-04	22	13	2	MM15104
Pathway	REACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB3	1.79e-04	22	13	2	M26929
Pathway	BIOCARTA_HER2_PATHWAY	ERBB2 ERBB3	1.96e-04	23	13	2	MM1480
Pathway	BIOCARTA_HER2_PATHWAY	ERBB2 ERBB3	1.96e-04	23	13	2	M18719
Pathway	REACTOME_LONG_TERM_POTENTIATION	GRIN2C GRIN2D	1.96e-04	23	13	2	M27949
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	ERBB2 ERBB3	2.33e-04	25	13	2	M47934
Pathway	REACTOME_SIGNALING_BY_ERBB2_IN_CANCER	ERBB2 ERBB3	2.52e-04	26	13	2	M29535
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING	ERBB2 ERBB3	2.52e-04	26	13	2	MM15501
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING	ERBB2 ERBB3	3.14e-04	29	13	2	M27756
Pathway	WP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4	ERBB2 ERBB3	4.08e-04	33	13	2	M39455
Pathway	WP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV	GRIN2C GRIN2D	4.08e-04	33	13	2	M39875
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	GRIN2C GRIN2D	4.59e-04	35	13	2	MM15109
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	GRIN2C GRIN2D	4.86e-04	36	13	2	M39831
Pathway	PID_ERBB2_ERBB3_PATHWAY	ERBB2 ERBB3	7.27e-04	44	13	2	M175
Pathway	REACTOME_SIGNALING_BY_ERBB2	ERBB2 ERBB3	7.27e-04	44	13	2	MM14520
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	GRIN2C GRIN2D	7.27e-04	44	13	2	M27934
Pathway	WP_ERBB_SIGNALING_PATHWAY	ERBB2 ERBB3	7.94e-04	46	13	2	MM15950
Pathway	PID_A6B1_A6B4_INTEGRIN_PATHWAY	ERBB2 ERBB3	7.94e-04	46	13	2	M239
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	GRIN2C GRIN2D	8.29e-04	47	13	2	M39531
Pathway	REACTOME_SIGNALING_BY_PTK6	ERBB2 ERBB3	8.65e-04	48	13	2	MM15479
Pathway	REACTOME_SIGNALING_BY_ERBB2	ERBB2 ERBB3	9.38e-04	50	13	2	M553
Pathway	WP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER	GRIN2C GRIN2D	9.38e-04	50	13	2	M39822
Pathway	KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	GRIN2C GRIN2D	1.05e-03	53	13	2	M3812
Pathway	REACTOME_SIGNALING_BY_PTK6	ERBB2 ERBB3	1.09e-03	54	13	2	M29742
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	ERBB2 ERBB3	1.13e-03	55	13	2	M47952
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	GRIN2C GRIN2D	1.13e-03	55	13	2	M39763
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	GRIN2C GRIN2D	1.18e-03	56	13	2	M27616
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	GRIN2C GRIN2D	1.68e-03	67	13	2	MM15327
Pathway	KEGG_LONG_TERM_POTENTIATION	GRIN2C GRIN2D	1.83e-03	70	13	2	M3115
Pathway	WP_ALZHEIMERS_DISEASE	GRIN2C GRIN2D	2.04e-03	74	13	2	MM15962
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_ABERRANT_PI3K_IN_CANCER	ERBB2 ERBB3	2.56e-03	83	13	2	M27163
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY	ERBB2 ERBB3	2.56e-03	83	13	2	M47961
Pathway	WP_GLIOBLASTOMA_SIGNALING	ERBB2 ERBB3	2.56e-03	83	13	2	M39637
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	ERBB2 ERBB3	2.62e-03	84	13	2	M39839
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	ERBB2 ERBB3 GRIN2D	2.75e-03	318	13	3	MM15278
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	GRIN2C GRIN2D	2.81e-03	87	13	2	M27617
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	ERBB2 ERBB3	2.81e-03	87	13	2	M12467
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY	ERBB2 ERBB3	2.94e-03	89	13	2	M47963
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	ERBB2 ERBB3 GRIN2D	2.98e-03	327	13	3	M27565
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY	ERBB2 ERBB3	3.14e-03	92	13	2	M47927
Pathway	WP_ERBB_SIGNALING	ERBB2 ERBB3	3.14e-03	92	13	2	M39715
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	GRIN2C GRIN2D	3.27e-03	94	13	2	M2843
Pathway	WP_IL6_SIGNALING_PATHWAY	ERBB2 ERBB3	3.69e-03	100	13	2	MM15826
Pathway	REACTOME_PI3K_AKT_SIGNALING_IN_CANCER	ERBB2 ERBB3	4.45e-03	110	13	2	M27162
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	ERBB2 ERBB3	4.69e-03	113	13	2	MM14783
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	ERBB2 ERBB3	5.10e-03	118	13	2	M713
Pathway	WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING	GRIN2C GRIN2D	7.11e-03	140	13	2	M42572
Pathway	WP_NRF2_PATHWAY	SLC6A15 SLC2A11	7.21e-03	141	13	2	M39454
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GRIN2C GRIN2D	7.51e-03	144	13	2	MM14501
Pathway	KEGG_ALZHEIMERS_DISEASE	GRIN2C GRIN2D	9.87e-03	166	13	2	M16024
Pubmed	H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3.	ERBB2 ERBB3	1.74e-07	2	15	2	20581867
Pubmed	Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.	ERBB2 ERBB3	1.74e-07	2	15	2	35108525
Pubmed	Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	17203234
Pubmed	Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling.	ERBB2 ERBB3	1.74e-07	2	15	2	22733765
Pubmed	Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1-Mediated Lung Cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	29959202
Pubmed	HER2 expression as a potential marker for response to therapy targeted to the EGFR.	ERBB2 ERBB3	1.74e-07	2	15	2	16622439
Pubmed	ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival.	ERBB2 ERBB3	1.74e-07	2	15	2	22157714
Pubmed	In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.	GRIN2C GRIN2D	1.74e-07	2	15	2	29651654
Pubmed	Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology.	ERBB2 ERBB3	1.74e-07	2	15	2	16199884
Pubmed	Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	30068375
Pubmed	Genomic profiling of pleomorphic and florid lobular carcinoma in situ reveals highly recurrent ERBB2 and ERRB3 alterations.	ERBB2 ERBB3	1.74e-07	2	15	2	31932682
Pubmed	HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value.	ERBB2 ERBB3	1.74e-07	2	15	2	25739551
Pubmed	Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling.	ERBB2 ERBB3	1.74e-07	2	15	2	20589763
Pubmed	Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells.	ERBB2 ERBB3	1.74e-07	2	15	2	10799311
Pubmed	Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.	GRIN2C GRIN2D	1.74e-07	2	15	2	31110197
Pubmed	Targeting HER2/HER3 co-mutations in metastatic breast cancer: Case reports of exceptional responders to trastuzumab and pertuzumab therapy.	ERBB2 ERBB3	1.74e-07	2	15	2	38441358
Pubmed	Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines.	ERBB2 ERBB3	1.74e-07	2	15	2	22806884
Pubmed	Oncogenic ERBB3 mutations in human cancers.	ERBB2 ERBB3	1.74e-07	2	15	2	23680147
Pubmed	Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	10205169
Pubmed	Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface.	ERBB2 ERBB3	1.74e-07	2	15	2	23843458
Pubmed	Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity.	ERBB2 ERBB3	1.74e-07	2	15	2	34171264
Pubmed	Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain.	ERBB2 ERBB3	1.74e-07	2	15	2	23688700
Pubmed	HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways.	ERBB2 ERBB3	1.74e-07	2	15	2	22983903
Pubmed	In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	21638049
Pubmed	HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models.	ERBB2 ERBB3	1.74e-07	2	15	2	27358485
Pubmed	Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.	GRIN2C GRIN2D	1.74e-07	2	15	2	29317596
Pubmed	Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu.	ERBB2 ERBB3	1.74e-07	2	15	2	17638894
Pubmed	The anti-HER3 antibody in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive gastric cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	27317872
Pubmed	The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation.	ERBB2 ERBB3	1.74e-07	2	15	2	12853564
Pubmed	Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase.	ERBB2 ERBB3	1.74e-07	2	15	2	21385943
Pubmed	Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome.	ERBB2 ERBB3	1.74e-07	2	15	2	21709195
Pubmed	CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes.	ERBB2 ERBB3	1.74e-07	2	15	2	28805349
Pubmed	Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association.	ERBB2 ERBB3	1.74e-07	2	15	2	12000754
Pubmed	Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors.	ERBB2 ERBB3	1.74e-07	2	15	2	12134143
Pubmed	Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.	ERBB2 ERBB3	1.74e-07	2	15	2	22248472
Pubmed	Higher-order association states of cellular ERBB3 probed with photo-cross-linkable aptamers.	ERBB2 ERBB3	1.74e-07	2	15	2	18942860
Pubmed	The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers.	ERBB2 ERBB3	1.74e-07	2	15	2	33907275
Pubmed	Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	22848366
Pubmed	A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.	ERBB2 ERBB3	1.74e-07	2	15	2	18056992
Pubmed	HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer.	ERBB2 ERBB3	1.74e-07	2	15	2	25915155
Pubmed	Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.	ERBB2 ERBB3	1.74e-07	2	15	2	12483526
Pubmed	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	ERBB2 ERBB3	1.74e-07	2	15	2	12888923
Pubmed	Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.	GRIN2C GRIN2D	1.74e-07	2	15	2	35057644
Pubmed	NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.	GRIN2C GRIN2D	1.74e-07	2	15	2	33766086
Pubmed	Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab.	ERBB2 ERBB3	1.74e-07	2	15	2	25112701
Pubmed	Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.	ERBB2 ERBB3	1.74e-07	2	15	2	14737100
Pubmed	Co-overexpression of HER2/HER3 is a predictor of impaired survival in breast cancer patients.	ERBB2 ERBB3	1.74e-07	2	15	2	25017122
Pubmed	Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice.	ERBB2 ERBB3	1.74e-07	2	15	2	15731393
Pubmed	Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3.	ERBB2 ERBB3	1.74e-07	2	15	2	23698633
Pubmed	Overexpression of ErbB2 and ErbB3 receptors in Schwann cells of patients with Charcot-Marie-tooth disease type 1A.	ERBB2 ERBB3	1.74e-07	2	15	2	16307437
Pubmed	The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells.	ERBB2 ERBB3	1.74e-07	2	15	2	35177646
Pubmed	Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.	ERBB2 ERBB3	1.74e-07	2	15	2	16168116
Pubmed	Increased erbB3 promotes erbB2/neu-driven mammary tumor proliferation and co-targeting of erbB2/erbB3 receptors exhibits potent inhibitory effects on breast cancer cells.	ERBB2 ERBB3	1.74e-07	2	15	2	26261492
Pubmed	Mechanistic Investigations of Diarrhea Toxicity Induced by Anti-HER2/3 Combination Therapy.	ERBB2 ERBB3	1.74e-07	2	15	2	29654069
Pubmed	Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.	ERBB2 ERBB3	1.74e-07	2	15	2	7538656
Pubmed	Pharmacological targeting of the pseudokinase Her3.	ERBB2 ERBB3	1.74e-07	2	15	2	25326665
Pubmed	Impact of HER2 codon 655 polymorphism and expression of HER2 and HER3 in non small cell lung cancer patients.	ERBB2 ERBB3	1.74e-07	2	15	2	26208475
Pubmed	Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.	ERBB2 ERBB3	1.74e-07	2	15	2	29338072
Pubmed	Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension.	ERBB2 ERBB3	1.74e-07	2	15	2	24678002
Pubmed	HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors.	ERBB2 ERBB3	1.74e-07	2	15	2	19622585
Pubmed	NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.	GRIN2C GRIN2D	1.74e-07	2	15	2	31786200
Pubmed	Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies.	ERBB2 ERBB3	1.74e-07	2	15	2	26138066
Pubmed	Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients.	ERBB2 ERBB3	1.74e-07	2	15	2	14614020
Pubmed	NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies.	ERBB2 ERBB3	5.21e-07	3	15	2	26770651
Pubmed	APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.	ERBB2 ERBB3	5.21e-07	3	15	2	26942872
Pubmed	EGFR, HER2, and HER3 protein expression in paired primary tumor and lymph node metastasis of colorectal cancer.	ERBB2 ERBB3	5.21e-07	3	15	2	35902718
Pubmed	[Correlation of epidermal growth factor receptor mutations and HER2/3 protein expression with clinical outcome in advanced non-small cell lung cancer patients treated with gefitinib].	ERBB2 ERBB3	5.21e-07	3	15	2	20038315
Pubmed	Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.	ERBB2 ERBB3	5.21e-07	3	15	2	7514177
Pubmed	Study of inhibition effect of herceptin on interaction between heregulin and erbB receptors HER3/HER2 by single-molecule force spectroscopy.	ERBB2 ERBB3	5.21e-07	3	15	2	19497323
Pubmed	A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion.	ERBB2 ERBB3	5.21e-07	3	15	2	28940194
Pubmed	Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers.	ERBB2 ERBB3	5.21e-07	3	15	2	17426253
Pubmed	Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1, 2 and 3 in Periampullary Adenocarcinoma.	ERBB2 ERBB3	5.21e-07	3	15	2	27070783
Pubmed	Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941.	ERBB2 ERBB3	5.21e-07	3	15	2	19411071
Pubmed	HER2 regulates cancer stem-like cell phenotype in ALK translocated NSCLC.	ERBB2 ERBB3	5.21e-07	3	15	2	28656214
Pubmed	Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.	GRIN2C GRIN2D	5.21e-07	3	15	2	9718984
Pubmed	Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.	GRIN2C GRIN2D	5.21e-07	3	15	2	35867797
Pubmed	Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4).	ERBB2 ERBB3	5.21e-07	3	15	2	28653892
Pubmed	Role of HER3 expression and PTEN loss in patients with HER2-overexpressing metastatic breast cancer (MBC) who received taxane plus trastuzumab treatment.	ERBB2 ERBB3	5.21e-07	3	15	2	24346286
Pubmed	A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy.	ERBB2 ERBB3	5.21e-07	3	15	2	18632642
Pubmed	Bivalence of EGF-like ligands drives the ErbB signaling network.	ERBB2 ERBB3	5.21e-07	3	15	2	9305636
Pubmed	Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.	ERBB2 ERBB3	5.21e-07	3	15	2	26372697
Pubmed	Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion.	ERBB2 ERBB3	5.21e-07	3	15	2	23062209
Pubmed	Dimerization drives EGFR endocytosis through two sets of compatible endocytic codes.	ERBB2 ERBB3	5.21e-07	3	15	2	25588832
Pubmed	Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer.	ERBB2 ERBB3	5.21e-07	3	15	2	25471734
Pubmed	EGFR/ERBB receptors differentially modulate sebaceous lipogenesis.	ERBB2 ERBB3	5.21e-07	3	15	2	25889637
Pubmed	The immunoexpression of EGFR, HER2 and HER3 in malignant serous ovarian tumors.	ERBB2 ERBB3	5.21e-07	3	15	2	29556616
Pubmed	Parallel visualization of multiple protein complexes in individual cells in tumor tissue.	ERBB2 ERBB3	5.21e-07	3	15	2	23436906
Pubmed	Mapping ErbB receptors on breast cancer cell membranes during signal transduction.	ERBB2 ERBB3	5.21e-07	3	15	2	17652160
Pubmed	WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling.	ERBB2 ERBB3	5.21e-07	3	15	2	26804171
Pubmed	Nuclear Y-box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer.	ERBB2 ERBB3	5.21e-07	3	15	2	19648825
Pubmed	The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.	ERBB2 ERBB3	5.21e-07	3	15	2	26534963
Pubmed	Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.	ERBB2 ERBB3	5.21e-07	3	15	2	7556068
Pubmed	Expression of PAM50 Genes in Lung Cancer: Evidence that Interactions between Hormone Receptors and HER2/HER3 Contribute to Poor Outcome.	ERBB2 ERBB3	5.21e-07	3	15	2	26678909
Pubmed	The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-γ1 signalling in breast cancer cell migration and dissemination.	ERBB2 ERBB3	5.21e-07	3	15	2	22262199
Pubmed	Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3.	ERBB2 ERBB3	5.21e-07	3	15	2	7592681
Pubmed	Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation.	ERBB2 ERBB3	5.21e-07	3	15	2	26490994
Pubmed	HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer.	ERBB2 ERBB3	5.21e-07	3	15	2	24706169
Pubmed	Tetraspanin CD151 impairs heterodimerization of ErbB2/ErbB3 in breast cancer cells.	ERBB2 ERBB3	5.21e-07	3	15	2	30639369
Pubmed	Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.	ERBB2 ERBB3	5.21e-07	3	15	2	34759323
Pubmed	Epidermal growth factor contains both positive and negative determinants for interaction with ErbB-2/ErbB-3 heterodimers.	ERBB2 ERBB3	5.21e-07	3	15	2	11914075
Interaction	MUC4 interactions	ERBB2 ERBB3	1.38e-05	9	13	2	int:MUC4
Interaction	ABL1 interactions	ERBB2 ERBB3 CDON GRIN2D	1.74e-05	259	13	4	int:ABL1
Interaction	SMIM20 interactions	ERBB2 ERBB3	3.48e-05	14	13	2	int:SMIM20
Interaction	TMEM134 interactions	ERBB2 ERBB3	5.20e-05	17	13	2	int:TMEM134
Interaction	SHD interactions	ERBB2 ERBB3	5.84e-05	18	13	2	int:SHD
Interaction	CDH2 interactions	ERBB2 CDON GRIN2D	8.73e-05	139	13	3	int:CDH2
Interaction	SHC4 interactions	ERBB2 ERBB3	8.81e-05	22	13	2	int:SHC4
Interaction	MERTK interactions	ERBB2 ERBB3 MDN1	8.92e-05	140	13	3	int:MERTK
Interaction	SOCS5 interactions	ERBB2 ERBB3	1.05e-04	24	13	2	int:SOCS5
Interaction	DUSP18 interactions	ERBB2 ERBB3	1.05e-04	24	13	2	int:DUSP18
Interaction	SLA2 interactions	ERBB2 ERBB3	1.05e-04	24	13	2	int:SLA2
Interaction	SH2B3 interactions	ERBB2 ERBB3	1.14e-04	25	13	2	int:SH2B3
Interaction	HSH2D interactions	ERBB2 ERBB3	1.14e-04	25	13	2	int:HSH2D
Interaction	ZNF532 interactions	ERBB2 ERBB3	1.34e-04	27	13	2	int:ZNF532
Interaction	STAP1 interactions	ERBB2 ERBB3	1.34e-04	27	13	2	int:STAP1
Interaction	SLA interactions	ERBB2 ERBB3	1.54e-04	29	13	2	int:SLA
Interaction	EGF interactions	ERBB2 ERBB3	1.77e-04	31	13	2	int:EGF
Interaction	GRB14 interactions	ERBB2 MAP3K14	1.77e-04	31	13	2	int:GRB14
Interaction	GRB7 interactions	ERBB2 ERBB3 MAP3K14	1.82e-04	178	13	3	int:GRB7
Interaction	SH2B1 interactions	ERBB2 ERBB3	1.88e-04	32	13	2	int:SH2B1
Interaction	TVP23B interactions	ERBB2 ERBB3	1.88e-04	32	13	2	int:TVP23B
Interaction	SH2D1B interactions	ERBB2 ERBB3	1.88e-04	32	13	2	int:SH2D1B
Interaction	BEND5 interactions	RTP5 ERBB3	1.88e-04	32	13	2	int:BEND5
Interaction	PLA2G2A interactions	ERBB2 ERBB3	2.67e-04	38	13	2	int:PLA2G2A
Interaction	HCST interactions	PIGN ERBB2 MDN1	2.75e-04	205	13	3	int:HCST
Interaction	OPALIN interactions	PIGN ERBB2 MDN1	2.91e-04	209	13	3	int:OPALIN
Interaction	ODF2L interactions	ERBB2 ERBB3	2.95e-04	40	13	2	int:ODF2L
Interaction	TNS1 interactions	ERBB2 ERBB3	3.11e-04	41	13	2	int:TNS1
Interaction	MATK interactions	ERBB2 ERBB3	3.42e-04	43	13	2	int:MATK
Interaction	SHC2 interactions	ERBB2 ERBB3	3.58e-04	44	13	2	int:SHC2
Interaction	SH2D1A interactions	ERBB2 ERBB3	3.74e-04	45	13	2	int:SH2D1A
Interaction	TMEM230 interactions	ERBB2 ERBB3	3.91e-04	46	13	2	int:TMEM230
Interaction	TMA7 interactions	ERBB2 ERBB3	3.91e-04	46	13	2	int:TMA7
Interaction	CLGN interactions	PIGN ERBB2 ERBB3	4.11e-04	235	13	3	int:CLGN
Interaction	SH3BP2 interactions	ERBB2 ERBB3	4.26e-04	48	13	2	int:SH3BP2
Interaction	BLNK interactions	ERBB2 ERBB3	4.26e-04	48	13	2	int:BLNK
Interaction	FGFR2 interactions	SLC6A15 ERBB2 ERBB3	4.31e-04	239	13	3	int:FGFR2
Interaction	FER interactions	ERBB2 ERBB3	4.62e-04	50	13	2	int:FER
Interaction	SH2D2A interactions	ERBB2 ERBB3	5.00e-04	52	13	2	int:SH2D2A
Interaction	SELENOK interactions	ERBB2 ERBB3	5.20e-04	53	13	2	int:SELENOK
Interaction	VAV3 interactions	ERBB2 ERBB3	5.60e-04	55	13	2	int:VAV3
Interaction	LCP2 interactions	ERBB2 ERBB3	5.60e-04	55	13	2	int:LCP2
Interaction	TXK interactions	ERBB2 ERBB3	6.01e-04	57	13	2	int:TXK
Interaction	LRRC7 interactions	ERBB2 ERBB3	6.22e-04	58	13	2	int:LRRC7
Interaction	SYNM interactions	ERBB2 ERBB3	6.22e-04	58	13	2	int:SYNM
Interaction	FES interactions	ERBB2 ERBB3	6.88e-04	61	13	2	int:FES
Interaction	CD82 interactions	ERBB2 ERBB3	6.88e-04	61	13	2	int:CD82
Interaction	ITK interactions	ERBB2 ERBB3	7.11e-04	62	13	2	int:ITK
Interaction	LRIG1 interactions	ERBB2 ERBB3	7.34e-04	63	13	2	int:LRIG1
Interaction	L1CAM interactions	ERBB2 ERBB3	7.57e-04	64	13	2	int:L1CAM
Interaction	BCAR3 interactions	ERBB2 ERBB3	8.05e-04	66	13	2	int:BCAR3
Interaction	HSPA1B interactions	DNMBP ERBB2 ERBB3	8.44e-04	301	13	3	int:HSPA1B
Interaction	SNAP91 interactions	ERBB2 ERBB3	9.05e-04	70	13	2	int:SNAP91
Interaction	PPM1F interactions	ERBB2 ERBB3	9.31e-04	71	13	2	int:PPM1F
Interaction	SHC3 interactions	ERBB2 ERBB3	9.57e-04	72	13	2	int:SHC3
Interaction	IL6ST interactions	ERBB2 ERBB3	1.01e-03	74	13	2	int:IL6ST
Interaction	SH2D3A interactions	ERBB2 ERBB3	1.04e-03	75	13	2	int:SH2D3A
Interaction	CFLAR interactions	ERBB3 MAP3K14	1.15e-03	79	13	2	int:CFLAR
Interaction	PIN4 interactions	ERBB2 ERBB3	1.21e-03	81	13	2	int:PIN4
Interaction	PTPRH interactions	ERBB2 ERBB3	1.30e-03	84	13	2	int:PTPRH
Interaction	SHB interactions	ERBB2 ERBB3	1.30e-03	84	13	2	int:SHB
Interaction	STYX interactions	ERBB2 ERBB3	1.30e-03	84	13	2	int:STYX
Interaction	MYCBP2 interactions	PIGN ERBB3 MDN1	1.36e-03	355	13	3	int:MYCBP2
Interaction	TNS3 interactions	ERBB2 ERBB3	1.39e-03	87	13	2	int:TNS3
Interaction	BMX interactions	ERBB2 ERBB3	1.49e-03	90	13	2	int:BMX
Interaction	TEC interactions	ERBB2 ERBB3	1.49e-03	90	13	2	int:TEC
Interaction	FAM241B interactions	ERBB2 ERBB3	1.49e-03	90	13	2	int:FAM241B
Interaction	ZAP70 interactions	ERBB2 ERBB3	1.56e-03	92	13	2	int:ZAP70
Interaction	FGR interactions	ERBB2 ERBB3	1.59e-03	93	13	2	int:FGR
Interaction	PIK3CB interactions	ERBB2 ERBB3	1.59e-03	93	13	2	int:PIK3CB
Interaction	DUSP19 interactions	ERBB2 ERBB3	1.69e-03	96	13	2	int:DUSP19
Interaction	CHN2 interactions	DNMBP ERBB3	1.73e-03	97	13	2	int:CHN2
Interaction	STMN2 interactions	ERBB2 MDN1	1.73e-03	97	13	2	int:STMN2
Interaction	VAV2 interactions	ERBB2 ERBB3	1.80e-03	99	13	2	int:VAV2
Interaction	PLCG2 interactions	ERBB2 ERBB3	1.83e-03	100	13	2	int:PLCG2
Interaction	PTK6 interactions	ERBB2 ERBB3	1.98e-03	104	13	2	int:PTK6
Interaction	PIGU interactions	PIGN SLC6A15	1.98e-03	104	13	2	int:PIGU
Interaction	GRAP2 interactions	ERBB2 ERBB3	1.98e-03	104	13	2	int:GRAP2
Interaction	NRG1 interactions	ERBB2 ERBB3	2.06e-03	106	13	2	int:NRG1
Interaction	DAB1 interactions	ERBB2 ERBB3	2.10e-03	107	13	2	int:DAB1
Interaction	ABL2 interactions	ERBB2 ERBB3	2.10e-03	107	13	2	int:ABL2
Interaction	PTPRR interactions	ERBB2 ERBB3	2.21e-03	110	13	2	int:PTPRR
Interaction	SOCS3 interactions	ERBB2 ERBB3	2.21e-03	110	13	2	int:SOCS3
Interaction	IRF2BP2 interactions	ERBB2 ERBB3	2.21e-03	110	13	2	int:IRF2BP2
Interaction	ILKAP interactions	ERBB2 ERBB3	2.21e-03	110	13	2	int:ILKAP
Interaction	EPHA3 interactions	SLC6A15 ERBB2	2.25e-03	111	13	2	int:EPHA3
Interaction	HSP90AB2P interactions	ERBB2 MAP3K14	2.25e-03	111	13	2	int:HSP90AB2P
Interaction	FKBP1A interactions	ERBB2 ERBB3	2.33e-03	113	13	2	int:FKBP1A
Interaction	RIN1 interactions	ERBB2 ERBB3	2.33e-03	113	13	2	int:RIN1
Interaction	SLC25A5 interactions	ERBB2 ERBB3 MAP3K14	2.37e-03	431	13	3	int:SLC25A5
Interaction	SOS1 interactions	ERBB2 ERBB3	2.50e-03	117	13	2	int:SOS1
Interaction	TEK interactions	ERBB2 MDN1	2.58e-03	119	13	2	int:TEK
Interaction	PTK2B interactions	ERBB2 ERBB3	2.58e-03	119	13	2	int:PTK2B
Interaction	GPR89A interactions	PIGN SLC6A15	2.63e-03	120	13	2	int:GPR89A
Interaction	DLG4 interactions	ERBB2 GRIN2C GRIN2D	2.66e-03	449	13	3	int:DLG4
Interaction	PATJ interactions	GRIN2C GRIN2D	2.85e-03	125	13	2	int:PATJ
Interaction	VAPB interactions	SLC6A15 ERBB2 ERBB3	2.92e-03	464	13	3	int:VAPB
Cytoband	Ensembl 112 genes in cytogenetic band chr18q21	PIGN DYNAP	2.01e-03	205	15	2	chr18q21
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	ERBB3 OR6C68	8.21e-03	423	15	2	chr12q13
GeneFamily	Erb-b2 receptor tyrosine kinases	ERBB2 ERBB3	3.34e-06	4	14	2	1096
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN2D	1.17e-05	7	14	2	1201
ToppCell	368C-Lymphocytic-ILC-ILC-2\|368C / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 CDON MDN1	2.37e-05	171	15	3	fd01076574dcc82bfd4a1538812500543b16794f
ToppCell	368C-Lymphocytic-ILC\|368C / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 CDON MDN1	2.37e-05	171	15	3	3b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell	368C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 CDON MDN1	2.77e-05	180	15	3	eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell	368C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 CDON MDN1	2.77e-05	180	15	3	ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ERBB2 ERBB3 CDON	3.00e-05	185	15	3	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PIGN ERBB2 ERBB3	3.15e-05	188	15	3	9155b9a92496e75646778c025b02947e9e9ec73a
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PIGN ERBB2 ERBB3	3.15e-05	188	15	3	c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell	TCGA-Mesothelium\|World / Sample_Type by Project: Shred V9	ATP10A CDON	8.49e-04	130	15	2	3ef1733eb57e2a9a3298ce0d65401f19e2084df1
ToppCell	droplet-Lung-nan-3m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 GRIN2C	1.03e-03	143	15	2	4d11d53330a9197275a8851e1bbf55a113715a09
ToppCell	droplet-Lung-nan-3m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 GRIN2C	1.03e-03	143	15	2	8b9f4d87d5faac7752c83e1992491fc5550600f8
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 MAP3K14	1.11e-03	149	15	2	defe2e4a2f3118f8b42e99a4f2bf03e54c1b698f
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RTP5 PIGN	1.19e-03	154	15	2	ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	ERBB3 MAP3K14	1.23e-03	157	15	2	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCell	Club_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 ERBB3	1.26e-03	159	15	2	a7bcff268b1962a561fd2848e01ae16565bce895
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDON GRIN2D	1.30e-03	161	15	2	deb10628d258fb813c293f81fb71be8e383dc82a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDON GRIN2D	1.30e-03	161	15	2	8aaca49b53a551395f4025ac4e535c7b0ce41a49
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIGN ERBB2	1.30e-03	161	15	2	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	Club-club-13\|World / Class top	SLC6A15 GRIN2D	1.31e-03	162	15	2	7d18f05a65ac715e62d610df9cc4a26539340dee
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RTP5 ATP10A	1.33e-03	163	15	2	004765e016c5658ee4a8bda4899804303064727b
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	SLC6A15 ERBB2	1.34e-03	164	15	2	08c725548e751f815b4df778607270498204b353
ToppCell	severe-unassigned\|severe / disease stage, cell group and cell class	DNMBP MAP3K14	1.36e-03	165	15	2	f9ddd547992fec065d539a1d0305acba8fc7d79c
ToppCell	facs-Lung-nan-3m-Epithelial-type_I_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 GRIN2D	1.38e-03	166	15	2	11b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCell	facs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 GRIN2D	1.38e-03	166	15	2	fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCell	Club-club-2\|World / Class top	SLC6A15 MAP3K14	1.38e-03	166	15	2	56f11efb6b686b3ee2c34a051f626e3d761b5112
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ATP10A ERBB3	1.41e-03	168	15	2	3fb79aaa858057c82645a90bd139fc4f096323c7
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDON GRIN2C	1.49e-03	173	15	2	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Basophil\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNMBP GRIN2D	1.49e-03	173	15	2	2cba41c3d9d3076f703115d19729073a3ac3feb6
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNMBP GRIN2D	1.49e-03	173	15	2	11d69a4ab4a87b8820cd3bd204de8c4124450a90
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDON GRIN2C	1.49e-03	173	15	2	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIGN ATP10A	1.51e-03	174	15	2	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIGN ATP10A	1.51e-03	174	15	2	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Myeloid-new-cluster\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 GRIN2D	1.51e-03	174	15	2	718e14d9a4264456459bec4c062c94c3a848d43a
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP10A CDON	1.51e-03	174	15	2	4da79da7a09ee1e345102c5331675ebcdbe56171
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDON GRIN2C	1.51e-03	174	15	2	a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDON GRIN2C	1.51e-03	174	15	2	a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell	10x3'2.3-week_17-19-Neuro-stroma-schwann_cells\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ERBB2 ERBB3	1.53e-03	175	15	2	8b010220cdfb680ec839572f4933adfb85045ea6
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 GRIN2D	1.53e-03	175	15	2	61fdafba120fbda063d4dc05263d6f8d1dcab1e1
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB3 GRIN2D	1.53e-03	175	15	2	8de8031fdf2af187642833feb80caa64932897cf
ToppCell	10x3'2.3-week_17-19-Neuro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ERBB2 ERBB3	1.53e-03	175	15	2	0b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell	10x3'2.3-week_17-19-Neuro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ERBB2 ERBB3	1.53e-03	175	15	2	bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 ERBB3	1.55e-03	176	15	2	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2C GRIN2D	1.55e-03	176	15	2	95d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RTP5 GRIN2D	1.58e-03	178	15	2	3c973aac16988e88f5677d3d695dd772ccfd6570
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERBB2 ERBB3	1.60e-03	179	15	2	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2C GRIN2D	1.60e-03	179	15	2	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATP10A CDON	1.60e-03	179	15	2	adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	ERBB2 ERBB3	1.60e-03	179	15	2	d5763912a4ce7188535675e338799b856edb9dda
ToppCell	AT2_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 ERBB3	1.63e-03	181	15	2	ed0ea67f0607073aedf153f8d1073b35e46127c3
ToppCell	BAL-Control-cDC_8\|Control / Compartment, Disease Groups and Clusters	DNMBP ATP10A	1.63e-03	181	15	2	f370161afef2ec827a7b194c06abb9ac1a507cbb
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RTP5 DNMBP	1.67e-03	183	15	2	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 ERBB3	1.67e-03	183	15	2	6821dca076318115d360ff426eb1218cfe104063
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	ERBB2 ERBB3	1.70e-03	185	15	2	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC6A15 GRIN2D	1.72e-03	186	15	2	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-chondrocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SLC6A15 ERBB3	1.72e-03	186	15	2	80a0a42ca8585cdb1dda57a18c254316a126ee64
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL14A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	ERBB3 CDON	1.72e-03	186	15	2	6259f0f2d5bc863782d09a901d6be2f387d1f074
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 GRIN2C	1.76e-03	188	15	2	505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC6A15 GRIN2D	1.76e-03	188	15	2	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC6A15 ERBB2	1.76e-03	188	15	2	c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 GRIN2C	1.78e-03	189	15	2	784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 GRIN2C	1.78e-03	189	15	2	37ecbd73408d462b47d7e5611f203143e08a2689
ToppCell	10x5'v1-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ERBB3 CDON	1.78e-03	189	15	2	473b01c9162b12b90a617c600238436177a0d18d
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 GRIN2C	1.80e-03	190	15	2	07f21386ea6eb23416a537d2250e3042efe93fb0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 GRIN2C	1.80e-03	190	15	2	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	BL-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB2 ERBB3	1.80e-03	190	15	2	f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCell	LAM-Epithelial-AT1\|LAM / Condition, Lineage and Cell class	ERBB2 ERBB3	1.82e-03	191	15	2	66875b2ec2c510489407f3e433a90cdf74a15094
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ATP10A CDON	1.82e-03	191	15	2	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 GRIN2C	1.82e-03	191	15	2	a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 GRIN2C	1.82e-03	191	15	2	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	ATP10A MAP3K14	1.83e-03	192	15	2	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ERBB2 ERBB3	1.85e-03	193	15	2	2d18f39615043dfbff120a00f6540ffa93082c83
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 ERBB3	1.85e-03	193	15	2	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	Club_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 ERBB3	1.85e-03	193	15	2	6582c0367052b9d10fb629c383ee0c55872afd2d
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ERBB2 ERBB3	1.85e-03	193	15	2	525e0de0f25f3308daf49e7d4c8774562f1f40ad
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-keratinocyte-new-cluster\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DNMBP DYNAP	1.87e-03	194	15	2	b847c5b4e8914b1c306bfff3d7119c32063784a8
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-keratinocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DNMBP DYNAP	1.87e-03	194	15	2	bd94d30584128628b34ed8c3857ce103586cfe2e
ToppCell	NS-critical-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB2 ERBB3	1.87e-03	194	15	2	2172d951896265243d14996eacce5aab5e14e26e
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERBB2 ERBB3	1.89e-03	195	15	2	576142b4e75457c0973051bccc4163bd624496af
ToppCell	normal_Lung-Epithelial_cells-AT1\|normal_Lung / Location, Cell class and cell subclass	ERBB2 ERBB3	1.89e-03	195	15	2	569d1ebc5a5aa110a2430b096755ae35354040c4
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERBB2 ERBB3	1.89e-03	195	15	2	b9a1c5836eb0ca92df788c3ee093b0d9ec7b8ad9
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERBB2 ERBB3	1.89e-03	195	15	2	8f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell	NS-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB2 ERBB3	1.89e-03	195	15	2	b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ERBB2 ERBB3	1.89e-03	195	15	2	b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERBB2 ERBB3	1.89e-03	195	15	2	2a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell	distal-Epithelial-Differentiating_Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ERBB2 ERBB3	1.89e-03	195	15	2	3fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCell	NS-moderate-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB2 ERBB3	1.91e-03	196	15	2	70384c1da9baed843f414cfd1403ddd586a2db07
ToppCell	(7)_Epithelial-I_(AT1)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ERBB2 ERBB3	1.91e-03	196	15	2	150554fa06868d29b0608189862eef6505ba757f
ToppCell	distal-3-Epithelial-Differentiating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ERBB2 ERBB3	1.91e-03	196	15	2	77635a0f86910c4019d3370e9c8ba41de176bcf3
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB2 ERBB3	1.91e-03	196	15	2	47930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell	critical-Epithelial-Secretory\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ERBB2 ERBB3	1.91e-03	196	15	2	7da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ERBB2 ERBB3	1.91e-03	196	15	2	d5f9168001e60bafec17fe6c702e68f5528edc20
ToppCell	NS-critical-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB2 ERBB3	1.93e-03	197	15	2	a72047b7428c0d4aaf016c1ac23dc30919260fd8
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ERBB2 CDON	1.93e-03	197	15	2	6b6504c47c309bac4f790e2f372d454bbdea49e8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC6A15 ERBB3	1.93e-03	197	15	2	54fb207638e211f8efdb13003ae62a6b1f003b09
ToppCell	21-Trachea-Epithelial-Club-like_secretory\|Trachea / Age, Tissue, Lineage and Cell class	ERBB2 ERBB3	1.95e-03	198	15	2	e735d82e5151c98b5724c543f8ad633c8ed824d2
ToppCell	moderate-Epithelial-Secretory\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ERBB2 ERBB3	1.95e-03	198	15	2	7d96d7105a849c7280ce87bd76ce130ac47384fd
ToppCell	moderate-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ERBB2 ERBB3	1.95e-03	198	15	2	7ecce5e266bb08797088cc8f8309e0c7b48df5c9
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-SMG_Basal/Duct\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ERBB2 ERBB3	1.95e-03	198	15	2	27a3c1c5ac855dff8d63f44eaa289be3f5bd621a
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	ERBB2 ERBB3	1.95e-03	198	15	2	a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB2 ERBB3	1.95e-03	198	15	2	e8bfae3888b2406b5629b576cb02913b3297337e
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 ERBB3	1.95e-03	198	15	2	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
Drug	2-acetamidoethanethiol	ERBB2 ERBB3	1.21e-06	3	15	2	ctd:C023704
Drug	enzacamene	ERBB2 ERBB3 GRIN2C GRIN2D	1.28e-06	129	15	4	ctd:C038939
Drug	octylmethoxycinnamate	ERBB2 ERBB3 GRIN2C GRIN2D	1.72e-06	139	15	4	ctd:C118580
Drug	butylparaben	ERBB2 ERBB3 GRIN2C GRIN2D	2.80e-06	157	15	4	ctd:C038091
Drug	5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione	GRIN2C GRIN2D	4.05e-06	5	15	2	ctd:C498554
Drug	(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid	GRIN2C GRIN2D	4.05e-06	5	15	2	ctd:C491996
Drug	2-Aminoadipic Acid	GRIN2C GRIN2D	4.05e-06	5	15	2	ctd:D015074
Drug	SDZ EAA 494	GRIN2C GRIN2D	4.05e-06	5	15	2	ctd:C065286
Drug	Naphthols	GRIN2C GRIN2D	6.07e-06	6	15	2	ctd:D009284
Drug	Meperidine	GRIN2C GRIN2D	6.07e-06	6	15	2	DB00454
Drug	1,5-(diethylamino)piperidine	GRIN2C GRIN2D	6.07e-06	6	15	2	CID000004025
Drug	ZD-6	ERBB2 ERBB3	6.07e-06	6	15	2	CID010062753
Drug	3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	GRIN2C GRIN2D	8.49e-06	7	15	2	ctd:C050592
Drug	Tenocyclidine	GRIN2C GRIN2D	8.49e-06	7	15	2	DB01520
Drug	tetrazol-5-yl)glycine	GRIN2C GRIN2D	8.49e-06	7	15	2	CID000126383
Drug	homoquinolinate	GRIN2C GRIN2D	8.49e-06	7	15	2	CID003080554
Drug	S)-piperazine-2-carboxylic acid	GRIN2C GRIN2D	8.49e-06	7	15	2	CID001502069
Drug	6-chloroquinoxaline-2,3-diol	GRIN2C GRIN2D	1.13e-05	8	15	2	CID000081143
Drug	ES-242-1	GRIN2C GRIN2D	1.13e-05	8	15	2	CID000131976
Drug	piperazine-2,3-dicarboxylic acid	GRIN2C GRIN2D	1.13e-05	8	15	2	CID000280973
Drug	SDZ 220-581	GRIN2C GRIN2D	1.13e-05	8	15	2	CID000128019
Drug	3alpha5betaHS	GRIN2C GRIN2D	1.13e-05	8	15	2	CID000165024
Drug	neramexane	GRIN2C GRIN2D	1.13e-05	8	15	2	CID006433106
Drug	Folfox protocol	ERBB2 ERBB3	1.13e-05	8	15	2	ctd:C410216
Drug	L-687,414	GRIN2C GRIN2D	1.13e-05	8	15	2	CID000125556
Drug	Phenanthrenes	GRIN2C GRIN2D	1.45e-05	9	15	2	ctd:D010616
Drug	Androgen Antagonists	ERBB2 ERBB3 GRIN2D	1.52e-05	75	15	3	ctd:D000726
Drug	AC1L1BWR	ERBB2 GRIN2C GRIN2D	1.58e-05	76	15	3	CID000001642
Drug	6-(methylamino)pyrido(3,4-d)pyrimidine	ERBB2 ERBB3	1.82e-05	10	15	2	ctd:C107875
Drug	5-phosphonopentanoic acid	GRIN2C GRIN2D	2.22e-05	11	15	2	CID002773807
Drug	EAB 515	GRIN2C GRIN2D	2.22e-05	11	15	2	CID000159489
Drug	o-difluorobenzene	GRIN2C GRIN2D	2.22e-05	11	15	2	CID000009706
Drug	BE-23372M	ERBB2 ERBB3	2.22e-05	11	15	2	CID005311105
Drug	Piperazines	GRIN2C GRIN2D	2.22e-05	11	15	2	ctd:D010879
Drug	oxiracetam	GRIN2C GRIN2D	2.22e-05	11	15	2	CID000004626
Drug	CI-1041	GRIN2C GRIN2D	2.66e-05	12	15	2	CID000156328
Drug	pY-5	ERBB3 MAP3K14	2.66e-05	12	15	2	CID000444861
Drug	tenocyclidine	GRIN2C GRIN2D	2.66e-05	12	15	2	CID000062751
Drug	CMF regimen	ERBB2 ERBB3	3.15e-05	13	15	2	ctd:C034456
Drug	Agmatine	GRIN2C GRIN2D	3.15e-05	13	15	2	ctd:D000376
Drug	1,10-diaminodecane	GRIN2C GRIN2D	3.15e-05	13	15	2	CID000001317
Drug	remacemide	GRIN2C GRIN2D	3.67e-05	14	15	2	CID000060510
Drug	thiokynurenic acid	GRIN2C GRIN2D	4.23e-05	15	15	2	CID003035667
Drug	ACEA-1011	GRIN2C GRIN2D	4.23e-05	15	15	2	CID000127872
Drug	NVP-TAE684	ERBB2 ERBB3	4.23e-05	15	15	2	ctd:C516714
Drug	4-anilinoquinazoline	ERBB2 ERBB3	4.84e-05	16	15	2	CID000324081
Drug	argiopine	GRIN2C GRIN2D	4.84e-05	16	15	2	CID000122294
Drug	3,4,7,8-tetrahydroquinoline	GRIN2C GRIN2D	4.84e-05	16	15	2	CID000094356
Drug	LY233536	GRIN2C GRIN2D	4.84e-05	16	15	2	CID000126239
Drug	metaphit	GRIN2C GRIN2D	4.84e-05	16	15	2	CID000114745
Drug	7-Cl-Thio-Kyna	GRIN2C GRIN2D	5.48e-05	17	15	2	CID003035668
Drug	PRE-084	GRIN2C GRIN2D	5.48e-05	17	15	2	CID000126402
Drug	ADCI	GRIN2C GRIN2D	5.48e-05	17	15	2	CID000130099
Drug	3-hydroxyglutaric acid	GRIN2C GRIN2D	6.16e-05	18	15	2	CID000181976
Drug	MNQX	GRIN2C GRIN2D	6.16e-05	18	15	2	CID000130818
Drug	NVP & EFV	ERBB2 GRIN2C GRIN2D	6.36e-05	121	15	3	CID000492400
Drug	arcaine	GRIN2C GRIN2D	6.88e-05	19	15	2	CID000002227
Drug	C22H28N2O4	GRIN2C GRIN2D	6.88e-05	19	15	2	CID000065570
Drug	IDRA 21	GRIN2C GRIN2D	7.64e-05	20	15	2	CID000003688
Drug	NCI60_002052	ERBB2 ERBB3	7.64e-05	20	15	2	CID006801032
Drug	diphenyl	CDON GRIN2C GRIN2D	8.24e-05	132	15	3	CID000007095
Drug	carbetapentane	GRIN2C GRIN2D	8.45e-05	21	15	2	CID000002562
Drug	NS 102	GRIN2C GRIN2D	9.29e-05	22	15	2	CID005282252
Drug	CX516	GRIN2C GRIN2D	9.29e-05	22	15	2	CID000148184
Drug	D-G-G	GRIN2C GRIN2D	1.02e-04	23	15	2	CID000444866
Drug	YM90K	GRIN2C GRIN2D	1.02e-04	23	15	2	CID005486547
Drug	AC1L1CT9	ERBB2 ERBB3	1.02e-04	23	15	2	CID000002054
Drug	pentanol	GRIN2C GRIN2D	1.02e-04	23	15	2	CID000006276
Drug	PHA665752	ERBB2 ERBB3	1.02e-04	23	15	2	CID010461815
Drug	CGP 39653	GRIN2C GRIN2D	1.11e-04	24	15	2	CID006437837
Drug	3-MP	CDON MAP3K14	1.11e-04	24	15	2	CID000007970
Drug	RS)-2-chloro-5-hydroxyphenylglycine	GRIN2C GRIN2D	1.11e-04	24	15	2	CID003645780
Drug	gavestinel	GRIN2C GRIN2D	1.20e-04	25	15	2	CID006450546
Drug	budipine	GRIN2C GRIN2D	1.20e-04	25	15	2	CID000068778
Drug	AC1NQH9B	GRIN2C GRIN2D	1.30e-04	26	15	2	CID005221504
Drug	AC1L1BL0	GRIN2C GRIN2D	1.30e-04	26	15	2	CID000001484
Drug	2-chloropropionate	GRIN2C GRIN2D	1.41e-04	27	15	2	CID000011734
Drug	benzylidenemalononitrile	ERBB2 ERBB3	1.41e-04	27	15	2	CID000017608
Drug	SKF 10,047	GRIN2C GRIN2D	1.41e-04	27	15	2	CID000001235
Drug	L-689,560	GRIN2C GRIN2D	1.41e-04	27	15	2	CID000121918
Drug	chlormethiazole	GRIN2C GRIN2D	1.52e-04	28	15	2	CID000010783
Drug	aptiganel	GRIN2C GRIN2D	1.52e-04	28	15	2	CID000060839
Drug	C-PP	GRIN2C GRIN2D	1.52e-04	28	15	2	CID000001228
Drug	AC1NUW3V	GRIN2C GRIN2D	1.63e-04	29	15	2	CID005462126
Drug	ketobemidone	GRIN2C GRIN2D	1.63e-04	29	15	2	CID000010101
Drug	Raloxifene Hydrochloride	DNMBP PIGN ERBB2 ERBB3 CDON	1.64e-04	857	15	5	ctd:D020849
Drug	LY293558	GRIN2C GRIN2D	1.74e-04	30	15	2	CID000127894
Drug	AC1L32TU	GRIN2C GRIN2D	1.74e-04	30	15	2	CID000107831
Drug	cis-2,3-piperidine dicarboxylic acid	GRIN2C GRIN2D	1.74e-04	30	15	2	CID000001226
Drug	GYKI 53655	GRIN2C GRIN2D	1.74e-04	30	15	2	CID000126757
Drug	LY235959	GRIN2C GRIN2D	1.86e-04	31	15	2	CID000131938
Drug	4-methylglutamic acid	GRIN2C GRIN2D	1.86e-04	31	15	2	CID000005365
Drug	eliprodil	GRIN2C GRIN2D	1.86e-04	31	15	2	CID000060703
Drug	NPC 12626	GRIN2C GRIN2D	1.86e-04	31	15	2	CID000108099
Drug	indole-2-carboxylic acid	GRIN2C GRIN2D	1.99e-04	32	15	2	CID000072899
Drug	remifentanil	GRIN2C GRIN2D	1.99e-04	32	15	2	CID000060814
Drug	NSC-673323	GRIN2C GRIN2D	1.99e-04	32	15	2	CID000384101
Drug	alpha-methyl-4-carboxyphenylglycine	GRIN2C GRIN2D	1.99e-04	32	15	2	CID000001222
Drug	pentamidine	GRIN2C GRIN2D	2.11e-04	33	15	2	CID000004735
Drug	Depixol	GRIN2C GRIN2D	2.11e-04	33	15	2	CID000017011
Disease	Head and Neck Carcinoma	ERBB2 ERBB3	8.05e-06	10	13	2	C3887461
Disease	gallbladder neoplasm	ERBB2 ERBB3	9.83e-06	11	13	2	C0016978
Disease	Malignant neoplasm of gallbladder	ERBB2 ERBB3	9.83e-06	11	13	2	C0153452
Disease	median neuropathy (biomarker_via_orthology)	ERBB2 ERBB3	1.63e-05	14	13	2	DOID:571 (biomarker_via_orthology)
Disease	Benign neoplasm of stomach	ERBB2 ERBB3	2.43e-05	17	13	2	C0153943
Disease	Carcinoma in situ of stomach	ERBB2 ERBB3	2.43e-05	17	13	2	C0154060
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB2 ERBB3	2.43e-05	17	13	2	C0496905
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB2 ERBB3	3.05e-05	19	13	2	DOID:2876 (is_marker_for)
Disease	Stomach Carcinoma	ERBB2 ERBB3	3.75e-05	21	13	2	C0699791
Disease	Nasopharyngeal carcinoma	ERBB2 ERBB3	4.12e-05	22	13	2	C2931822
Disease	stomach carcinoma (is_marker_for)	ERBB2 ERBB3	4.92e-05	24	13	2	DOID:5517 (is_marker_for)
Disease	Ovarian Mucinous Adenocarcinoma	ERBB3 MAP3K14	8.27e-05	31	13	2	C1335167
Disease	intestinal cancer (implicated_via_orthology)	ERBB2 ERBB3	8.82e-05	32	13	2	DOID:10155 (implicated_via_orthology)
Disease	Head and Neck Neoplasms	ERBB2 ERBB3	9.39e-05	33	13	2	C0018671
Disease	ductal carcinoma in situ (is_marker_for)	ERBB2 ERBB3	1.32e-04	39	13	2	DOID:0060074 (is_marker_for)
Disease	Malignant Head and Neck Neoplasm	ERBB2 ERBB3	1.68e-04	44	13	2	C0278996
Disease	lung adenocarcinoma (is_implicated_in)	ERBB2 ERBB3	2.08e-04	49	13	2	DOID:3910 (is_implicated_in)
Disease	developmental disorder of mental health (implicated_via_orthology)	GRIN2C GRIN2D	2.08e-04	49	13	2	DOID:0060037 (implicated_via_orthology)
Disease	transitional cell carcinoma (is_marker_for)	ERBB2 ERBB3	3.45e-04	63	13	2	DOID:2671 (is_marker_for)
Disease	carcinoma (implicated_via_orthology)	ERBB2 ERBB3	3.56e-04	64	13	2	DOID:305 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	ERBB2 ERBB3	4.38e-04	71	13	2	DOID:0050700 (implicated_via_orthology)
Disease	urinary bladder cancer (is_marker_for)	ERBB2 ERBB3	9.90e-04	107	13	2	DOID:11054 (is_marker_for)
Disease	endometrial carcinoma	SLC6A15 MDN1	1.10e-03	113	13	2	EFO_1001512
Disease	Malignant Neoplasms	ERBB2 ERBB3	1.41e-03	128	13	2	C0006826
Disease	epilepsy (implicated_via_orthology)	GRIN2C GRIN2D	2.27e-03	163	13	2	DOID:1826 (implicated_via_orthology)
Disease	Disease Exacerbation	ERBB2 ERBB3	2.33e-03	165	13	2	C0235874
Disease	alcohol use disorder (implicated_via_orthology)	ERBB2 ERBB3	3.23e-03	195	13	2	DOID:1574 (implicated_via_orthology)
Disease	Adenocarcinoma of lung (disorder)	PIGN ERBB2	3.60e-03	206	13	2	C0152013
Disease	asthma	ERBB2 ERBB3 MAP3K14	3.88e-03	751	13	3	MONDO_0004979
Disease	Neoplasm Metastasis	ERBB2 ERBB3	3.98e-03	217	13	2	C0027627
Disease	smoking behaviour measurement	SLC6A15 ERBB3	4.16e-03	222	13	2	EFO_0005671

Protein segments in the cluster

Peptide	Gene	Start	Entry
ICTIDVYMIMVKCWM	ERBB2	946	P04626
VYMIMVKCWMIDSEC	ERBB2	951	P04626
CTIDVYMVMVKCWMI	ERBB3	936	P21860
CVKVVAAVSMWDVCM	DNMBP	1056	Q6XZF7
MNCDVLWCVLLLVCM	ATP10A	306	O60312
SIMKCVQMSWMVILV	MDN1	2051	Q9NU22
AACMVCGALMWIMLI	SLC2A11	406	Q9BYW1
MVLILMVFIAMCLWK	CDON	976	Q4KMG0
MWKVFLACLLACVIM	DYNAP	111	Q8N1N2
KVDVWSSCCMMLHML	MAP3K14	576	Q99558
IWVSMTVCVFWLMCM	RTP5	546	Q14D33
CLLAAWVMVCLAMIK	SLC6A15	231	Q9H2J7
TMVICCWMAALMIIL	OR6C68	141	A6NDL8
MMWKILIPFVLVMCA	PIGN	831	O95427
WVMMFVMCLTVVAIT	GRIN2C	556	Q14957
WVMMFVMCLTVVAVT	GRIN2D	586	O15399