Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Elevated circulating hepatic transaminase concentration	MKKS SLC25A20 BRCA2 PEX2 CPT1A HSD17B4 GNMT ALG6	5.51e-06	370	16	8	HP:0002910
HumanPheno	Abnormal circulating hepatic transaminase concentration	MKKS SLC25A20 BRCA2 PEX2 CPT1A HSD17B4 GNMT ALG6	5.51e-06	370	16	8	HP:0430135
HumanPheno	Abnormal liver function tests	MKKS SLC25A20 BRCA2 PEX2 CPT1A HSD17B4 GNMT ALG6	5.51e-06	370	16	8	HP:0001411
Pubmed	Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.	HK2 BRCA2	7.91e-06	3	57	2	25176644
Pubmed	Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences.	SLC25A20 CPT1A	2.63e-05	5	57	2	28671672
Pubmed	Etomoxir regulates the differentiation of male germ cells by specifically reducing H3K27ac level.	HK2 CPT1A	5.51e-05	7	57	2	33517883
Pubmed	Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.	BRCA2 HSD17B4	7.34e-05	8	57	2	18086758
Pubmed	Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.	OPN1SW TOP2B	9.43e-05	9	57	2	28370415
Pubmed	Molecular enzymology of carnitine transfer and transport.	SLC25A20 CPT1A	9.43e-05	9	57	2	11257506
Pubmed	Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo.	GREB1 HSD17B4	1.18e-04	10	57	2	18794456
Pubmed	The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.	XRN1 TRIM71	1.18e-04	10	57	2	23125361
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	XRN1 SMC4 NEURL4 TOP2B	3.43e-04	202	57	4	33005030
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	SGSM1 JADE2 KHNYN TSTD2 SERPINA7	3.57e-04	371	57	5	15747579
Pubmed	AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.	SLC25A20 CPT1A	3.97e-04	18	57	2	16054041
Pubmed	Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.	HK2 KHNYN CPT1A	5.86e-04	99	57	3	31723608
Pubmed	Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells.	OPN1SW TOP2B	6.53e-04	23	57	2	24463367
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	BRCA2 USP1	7.12e-04	24	57	2	21466675
Pubmed	GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.	HK2 CPT1A	7.73e-04	25	57	2	32913122
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	PEX2 HSD17B4	8.36e-04	26	57	2	30378028
Pubmed	Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.	HK2 CPT1A	9.02e-04	27	57	2	24086110
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	PEX2 HSD17B4	9.71e-04	28	57	2	22002062
Pubmed	Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.	HK2 CPT1A	1.11e-03	30	57	2	27133129
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	BRCA2 USP1	1.19e-03	31	57	2	19690177
Pubmed	TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.	BRCA2 SMC4	1.19e-03	31	57	2	26095369
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF26 ZNF37A	1.19e-03	31	57	2	2288909
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	MKKS TRAF7 SMC4 TMEM131L USP1 NUAK2	1.41e-03	750	57	6	11230166
Pubmed	Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.	RBM11 ZC2HC1A ZNF740 NUAK2	1.59e-03	305	57	4	21244100
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF26 ZNF556 ZNF37A ZNF569 ZNF740	1.18e-02	718	35	5	28
GeneFamily	Ring finger proteins	TRAF7 PEX2 TRIM71	1.59e-02	275	35	3	58
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_NONRESPONDER_7DY_UP	MKKS ZNF26 XRN1 ALG6 TOP2B	8.44e-06	127	57	5	M40905
Drug	Piperine [94-62-2]; Up 200; 14uM; MCF7; HT_HG-U133A	ATP8A1 CLCA2 ENPP2 TRPM8 GREB1 ST7L OPN1SW	6.19e-07	198	57	7	4830_UP
Disease	Disorder of fatty acid metabolism	SLC25A20 CPT1A	1.17e-04	9	54	2	cv:C0268634
Disease	Zellweger Spectrum	PEX2 HSD17B4	2.53e-04	13	54	2	C3658299
Disease	Zellweger-Like Syndrome	PEX2 HSD17B4	2.53e-04	13	54	2	C0751594
Disease	Hepatitis	ENPP2 GNMT	3.40e-04	15	54	2	C0019158
Disease	Adrenoleukodystrophy, Neonatal	PEX2 HSD17B4	3.40e-04	15	54	2	C0282525
Disease	lipid metabolism disorder (implicated_via_orthology)	SLC25A20 HSD17B4	3.40e-04	15	54	2	DOID:3146 (implicated_via_orthology)
Disease	Zellweger Syndrome	PEX2 HSD17B4	3.88e-04	16	54	2	C0043459
Disease	thyroxine measurement	TRIM71 ACMSD SERPINA7	4.80e-04	83	54	3	EFO_0005130
Disease	unipolar depression, schizophrenia	AGBL4 ZNF804A	9.60e-04	25	54	2	EFO_0003761, MONDO_0005090
Disease	non-alcoholic fatty liver disease, type 2 diabetes mellitus	AMZ1 XXYLT1 ALG6	1.09e-03	110	54	3	EFO_0003095, MONDO_0005148

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCSGSGPFTFLHFDK	ADGRB2	141	O60241
FTFSKFLPGHEVGVC	AMZ1	191	Q400G9
FGVTLFGAFVPKHFQ	CATSPER4	231	Q7RTX7
HALPFFCFLLGKCFK	ALG6	206	Q9Y672
FHSFPFVAFGKGIIK	CPT1A	546	P50416
VFEKFPKLKVCFAHG	ACMSD	211	Q8TDX5
FKKCTIAGVAYGHVP	ATP8A1	421	Q9Y2Q0
EGKPKSFGFVCFKHP	RBM11	46	P57052
GNFKGLCKQIDHFPE	CACNG2	71	Q9Y698
CTAKFGSKHFFHLIP	MKKS	351	Q9NPJ1
QVFKPCGAFHHKFGT	TRIM71	631	Q2Q1W2
KPVIFKGHGNFPYLC	GREB1	381	Q4ZG55
KKLPLGFTFSFPCHQ	HK2	146	P52789
KFKSFCQEHSDGGPR	JADE2	356	Q9NQC1
QFTQCFHGFKPGLLA	PEX2	36	P28328
FAVCFFGFGLGKKLQ	SLC25A20	86	O43772
FGGKCQHSVLGDFKP	GNMT	261	Q14749
EFGLQKFHKPLATFS	METTL21A	11	Q8WXB1
VTILCDKFSGHPKGF	PABPN1	201	Q86U42
CGSLFHTPKFVKGRQ	BRCA2	161	P51587
FAKPNIFCHFAQGIG	DNAH17	2726	Q9UFH2
FDKPILHGLCTFGFS	HSD17B4	526	P51659
KKQPFCDGSHFFQRT	CISD3	66	P0C7P0
CGQPKKGHLIFDACF	AGBL4	36	Q5VU57
PKLHCIFLGAQGFFL	KHNYN	86	O15037
FAGPHAALANKSFFK	EIF2A	206	Q9BY44
FIFPHCGRKAGVAKN	FDXACB1	86	Q9BRP7
PSGSFKIRGIGHFCK	SDS	36	P20132
HFGPVFFGSSKIKHA	CFAP47	256	Q6ZTR5
VYKKPSGKCFFQGDH	ENPP2	461	Q13822
GVFHNGLKICEKFGP	NEURL4	1221	Q96JN8
GKPGTFLKKNFHGCI	CNTNAP5	316	Q8WYK1
ICKPFGNFRFSSKHA	OPN1SW	136	P03999
DGFKPGQRKVLFTCF	TOP2B	741	Q02880
FSDKLFSGKGLHFQP	TMEM131L	81	A2VDJ0
CFGPSFLTLHGGKKA	FER1L5	431	A0AVI2
NGAKVCSFFKQHAPG	NUAK2	346	Q9H093
GCGKEGKYIHFTPNF	CLCA2	131	Q9UQC9
CGKAFPENSLFLVHK	ZNF37A	151	P17032
GFQHLICSLNFPKKE	SERPINA7	111	P05543
GKAFSCPKAFQGHVR	ZNF556	431	Q9HAH1
QKALYFCGFPTLKHI	XRN1	651	Q8IZH2
FCGFPTLKHIRHKFF	XRN1	656	Q8IZH2
DPQQIFKCKGTFVGH	TRAF7	381	Q6Q0C0
AGEKILGPFHKRFSC	SMC4	96	Q9NTJ3
KKELPLFIHFTAGFC	ST7L	506	Q8TDW4
DFKTSKGGAHCFPEL	TSTD2	241	Q5T7W7
FRFPKGGHLLQFLSC	SGSM1	351	Q2NKQ1
ICGRTFFPVALKKHG	ZC2HC1A	21	Q96GY0
FVITPFKCNHCGKGF	ZNF569	181	Q5MCW4
CGKAFSLKSPFVVHQ	ZNF26	291	P17031
NFEFVGGLHCKPAKA	UGT2A3	271	Q6UWM9
GCGFVSFRKKPVDKH	TRPM8	706	Q7Z2W7
KIPKNFVCEHCFGAF	ZNF740	96	Q8NDX6
FCPGFKSGVKHLFNI	USP1	101	O94782
PAAGFKCKVIFHDVA	XXYLT1	161	Q8NBI6
GIHRHKIGFSFAFPK	ZNF804A	206	Q7Z570
KGKFPFHFVEVLACA	NARF	361	Q9UHQ1