Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	response to water	UMOD PLEC SIPA1	1.91e-05	14	79	3	GO:0009415
Domain	SR	SSC4D CD163L1 CORIN DMBT1 CD163	6.72e-08	25	81	5	SM00202
Domain	SRCR_1	SSC4D CD163L1 CORIN DMBT1 CD163	8.29e-08	26	81	5	PS00420
Domain	SRCR_2	SSC4D CD163L1 CORIN DMBT1 CD163	8.29e-08	26	81	5	PS50287
Domain	SRCR-like_dom	SSC4D CD163L1 CORIN DMBT1 CD163	8.29e-08	26	81	5	IPR017448
Domain	SRCR	SSC4D CD163L1 CORIN DMBT1 CD163	1.01e-07	27	81	5	IPR001190
Domain	SRCR	SSC4D CD163L1 DMBT1 CD163	1.86e-06	21	81	4	PF00530
Domain	-	SSC4D CD163L1 DMBT1 CD163	3.87e-06	25	81	4	3.10.250.10
Domain	Cadherin_tail	PCDHA7 PCDHA4 PCDHA3	5.49e-04	37	81	3	PF15974
Domain	Cadherin_CBD	PCDHA7 PCDHA4 PCDHA3	5.49e-04	37	81	3	IPR031904
Domain	ZP_dom_CS	UMOD DMBT1	8.17e-04	10	81	2	IPR017977
Domain	ZP_1	UMOD DMBT1	1.63e-03	14	81	2	PS00682
Domain	ZP_2	UMOD DMBT1	1.63e-03	14	81	2	PS51034
Domain	ZP	UMOD DMBT1	1.88e-03	15	81	2	SM00241
Domain	ZP_dom	UMOD DMBT1	2.42e-03	17	81	2	IPR001507
Domain	Zona_pellucida	UMOD DMBT1	2.42e-03	17	81	2	PF00100
Domain	Cadherin_2	PCDHA7 PCDHA4 PCDHA3	2.83e-03	65	81	3	PF08266
Domain	Cadherin_N	PCDHA7 PCDHA4 PCDHA3	2.83e-03	65	81	3	IPR013164
Pubmed	Bone marrow-derived cells are required for the induction of a pulmonary inflammatory response mediated by CD40 ligation.	IGHM CD40	5.49e-06	2	82	2	10079270
Pubmed	Dynamics of MHC class II-activating signals in murine resting B cells.	IGHM CD40	5.49e-06	2	82	2	16393966
Pubmed	Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.	CD163L1 CD163	5.49e-06	2	82	2	11124526
Pubmed	Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library.	ANKRD30A ANKRD30B	5.49e-06	2	82	2	11280766
Pubmed	Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.	SLC22A9 SLC22A11	5.49e-06	2	82	2	10660625
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA7 PCDHA4 PCDHA3	5.63e-06	15	82	3	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA7 PCDHA4 PCDHA3	8.39e-06	17	82	3	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA7 PCDHA4 PCDHA3	1.00e-05	18	82	3	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA7 PCDHA4 PCDHA3	1.00e-05	18	82	3	10662547
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF462 KIF23 ANLN POLA1 ZNF570 WDR70 TOPBP1 WDR12 ZMYM3	1.36e-05	608	82	9	36089195
Pubmed	CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection.	IGHM CD40	1.64e-05	3	82	2	16237075
Pubmed	MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination.	MEIOB RPA2	1.64e-05	3	82	2	24240703
Pubmed	B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.	IGHM CD40	1.64e-05	3	82	2	16393971
Pubmed	NKT-cell help to B lymphocytes can occur independently of cognate interaction.	IGHM CD40	1.64e-05	3	82	2	18832653
Pubmed	Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta.	SLC22A9 SLC22A11	1.64e-05	3	82	2	18501590
Pubmed	CD40 Drives Central Nervous System Autoimmune Disease by Inducing Complementary Effector Programs via B Cells and Dendritic Cells.	IGHM CD40	1.64e-05	3	82	2	36426970
Pubmed	Astrocyte-mediated regulation of BLAWFS1 neurons alleviates risk-assessment deficits in DISC1-N mice.	WFS1 DISC1	1.64e-05	3	82	2	38642554
Pubmed	CD73 expression identifies a subset of IgM+ antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent.	IGHM CD40	1.64e-05	3	82	2	28746783
Pubmed	Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help.	IGHM CD40	1.64e-05	3	82	2	22379027
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA7 PCDHA4 PCDHA3	2.47e-05	24	82	3	24698270
Pubmed	Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules.	SLC22A9 SLC22A11	3.28e-05	4	82	2	15037815
Pubmed	Impaired germinal center maturation in adenosine deaminase deficiency.	IGHM CD40	3.28e-05	4	82	2	14607964
Pubmed	CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza.	IGHM CD40	3.28e-05	4	82	2	23835849
Pubmed	Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells.	IGHM CD40	3.28e-05	4	82	2	16517718
Pubmed	Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.	ASXL1 IGHM	3.28e-05	4	82	2	19861679
Pubmed	A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus.	IGHM CD40	3.28e-05	4	82	2	18768874
Pubmed	B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells.	IGHM CD40	3.28e-05	4	82	2	29396161
Pubmed	Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.	IGHM CD40	3.28e-05	4	82	2	31484732
Pubmed	B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo.	IGHM CD40	3.28e-05	4	82	2	17202317
Pubmed	Isolation of a family of organic anion transporters from human liver and kidney.	SLC22A9 SLC22A11	3.28e-05	4	82	2	11327718
Pubmed	Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.	IGHM CD40	3.28e-05	4	82	2	25035957
Pubmed	Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus.	IGHM CD40	3.28e-05	4	82	2	16272340
Pubmed	A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.	KIF23 ANLN	3.28e-05	4	82	2	36894036
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA7 PCDHA4 PCDHA3	3.97e-05	28	82	3	15347688
Pubmed	Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.	IGHM CD40	5.47e-05	5	82	2	28768709
Pubmed	The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.	IGHM CD40	5.47e-05	5	82	2	19805369
Pubmed	Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.	IGHM CD40	5.47e-05	5	82	2	20691615
Pubmed	ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.	KIF23 YWHAQ	5.47e-05	5	82	2	22580824
Pubmed	Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis.	KIF23 YWHAQ	5.47e-05	5	82	2	20451386
Pubmed	T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation.	IGHM CD40	8.19e-05	6	82	2	12538659
Pubmed	Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.	PPARGC1A PERM1	8.19e-05	6	82	2	23836911
Pubmed	TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.	IGHM CD40	8.19e-05	6	82	2	16195331
Pubmed	MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation.	YWHAQ MAP3K4	8.19e-05	6	82	2	21152872
Pubmed	ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.	IGHM CD40	8.19e-05	6	82	2	21636296
Pubmed	CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α.	PPARGC1A RBX1	1.14e-04	7	82	2	26407237
Pubmed	CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.	IGHM CD40	1.14e-04	7	82	2	8666928
Pubmed	Mouse model resources for vision research.	MDM1 RP1 AGTPBP1	1.26e-04	41	82	3	21052544
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	KIF23 ANLN POLA1 PLEC YWHAQ ZMYM3	1.38e-04	332	82	6	32786267
Pubmed	Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.	MAPKAP1 RBX1	1.52e-04	8	82	2	20832730
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	MYO15B CAPZA2 PLEC	1.67e-04	45	82	3	22114352
Pubmed	Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.	MAPKAP1 GNB4 YWHAQ	1.67e-04	45	82	3	22926577
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	KIF23 CAPZA2 WDR12 PLEC YWHAQ AGTPBP1 RBX1	1.74e-04	496	82	7	31343991
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 MAPKAP1 KIF23 ANLN LSG1 PLEC YWHAQ MAP3K21 AGAP3	1.95e-04	861	82	9	36931259
Pubmed	Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.	PPARGC1A PERM1	1.96e-04	9	82	2	34029594
Pubmed	Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.	IGHM CD40	1.96e-04	9	82	2	16973390
Pubmed	Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function.	IGHM CD40	2.44e-04	10	82	2	16775321
Pubmed	Differential requirements of CD45 for lymphocyte development and function.	IGHM CD40	2.98e-04	11	82	2	8566034
Pubmed	Timing and casting for actors of thymic negative selection.	IGHM CD40	2.98e-04	11	82	2	9973382
Pubmed	A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.	GNB4 RBX1	2.98e-04	11	82	2	25982117
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA7 PCDHA4	2.98e-04	11	82	2	9655502
Pubmed	Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling.	CMYA5 CCN3	2.98e-04	11	82	2	30410445
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	KIF23 ANLN LSG1 POLA1 A2ML1 WDR70 CAPZA2 PRR14L PLEC YWHAQ ZMYM3	3.30e-04	1353	82	11	29467282
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA7 PCDHA4 PCDHA3	3.37e-04	57	82	3	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA7 PCDHA4 PCDHA3	3.55e-04	58	82	3	30377227
Pubmed	Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G-Protein β-Subunit Ubiquitination and Downstream Signaling.	GNB4 RBX1	3.57e-04	12	82	2	34342229
Pubmed	RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.	POLA1 RPA2	3.57e-04	12	82	2	11473323
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA7 PCDHA4	3.57e-04	12	82	2	10612399
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SSC4D POMGNT1 ANKRD24 SIPA1 CD163 CCN3 AGAP3	3.62e-04	560	82	7	21653829
Pubmed	IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.	IGHM CD40	4.21e-04	13	82	2	28137874
Pubmed	The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size.	KIF23 ANLN	4.21e-04	13	82	2	24173802
Pubmed	Protein interaction and cellular localization of human CDC45.	TOPBP1 RPA2	4.21e-04	13	82	2	23364835
Pubmed	Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice.	IGHM CD40	4.21e-04	13	82	2	23006848
Pubmed	MEIOB targets single-strand DNA and is necessary for meiotic recombination.	MEIOB RPA2	4.91e-04	14	82	2	24068956
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	PCDHA4 PLEC	4.91e-04	14	82	2	14672974
Pubmed	Screening of the interaction between xenobiotic transporters and PDZ proteins.	SLC22A9 SLC22A11	5.65e-04	15	82	2	15553237
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA7 PCDHA4 PCDHA3	5.67e-04	68	82	3	11230163
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	TPP2 POLA1 BAG1 CAPZA2 CARS1 WDR12 PLEC YWHAQ CMYA5 RPA2 RBX1	6.07e-04	1455	82	11	22863883
Pubmed	CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer.	IGHM CD40	6.45e-04	16	82	2	27292635
Pubmed	Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.	ASXL1 WDR12	6.45e-04	16	82	2	18258596
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA7 PCDHA4 PCDHA3	6.70e-04	72	82	3	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA7 PCDHA4 PCDHA3	7.26e-04	74	82	3	10817752
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA7 PCDHA4 PCDHA3	7.55e-04	75	82	3	15372022
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA7 PCDHA4 PCDHA3	8.15e-04	77	82	3	10835267
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	CLEC4A SCN5A	8.20e-04	18	82	2	31666509
Pubmed	MORC2B is essential for meiotic progression and fertility.	MEIOB RPA2	8.20e-04	18	82	2	29329290
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ZNF462 KIF23 LSG1 A2ML1 CAPZA2 WDR12 GNB4 ZMYM3	8.72e-04	847	82	8	35850772
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	CAPZA2 TOPBP1 GNB4 PLEC YWHAQ RPA2 RBX1	8.89e-04	652	82	7	31180492
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA7 PCDHA4 PCDHA3	9.11e-04	80	82	3	10716726
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	NEUROD1 POMGNT1 RP1	9.44e-04	81	82	3	20301590
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	CAPZA2 PLEC YWHAQ	9.44e-04	81	82	3	20697350
Pubmed	Human immunodeficiency virus type 1 Vpr: functions and molecular interactions.	CD40 YWHAQ	1.01e-03	20	82	2	19458171
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	OGFRL1 PPARGC1A ANO9 NEUROD1 RHBDF1 ANLN CAPZA2 PLEC YWHAQ	1.03e-03	1084	82	9	11544199
Pubmed	Limb-Girdle Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	POMGNT1 PLEC	1.12e-03	21	82	2	20301582
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	ZNF462 MAPKAP1 ASXL1 YWHAQ ZMYM3 RBX1	1.13e-03	495	82	6	27705803
Pubmed	Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.	DMBT1 RBX1	1.23e-03	22	82	2	26631746
Pubmed	SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.	MEIOB RPA2	1.23e-03	22	82	2	35489071
Pubmed	Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.	MEIOB RPA2	1.23e-03	22	82	2	26742488
Pubmed	Klf14 is an imprinted transcription factor that regulates placental growth.	PPARGC1A ENPP2	1.35e-03	23	82	2	31675530
Pubmed	The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.	TOPBP1 UMOD YWHAQ	1.50e-03	95	82	3	20843830
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	KIAA1671 PLEC	1.59e-03	25	82	2	30309841
Interaction	LIMA1 interactions	MAPKAP1 KIF23 ANLN POLA1 DISC1 CAPZA2 PLEC YWHAQ SIPA1 MAP3K21 RPA2	1.00e-06	429	80	11	int:LIMA1
Interaction	RACGAP1 interactions	KIF23 ANLN CAPZA2 YWHAQ RPA2 MAP3K4 AGAP3	1.89e-05	208	80	7	int:RACGAP1
Interaction	ACSL4 interactions	SLC22A9 KIF23 ANLN IGHM YWHAQ RPA2	1.99e-05	140	80	6	int:ACSL4
Interaction	SIPA1 interactions	ANLN CAPZA2 YWHAQ SIPA1	2.08e-05	41	80	4	int:SIPA1
Interaction	PHLDB2 interactions	MAPKAP1 KIF23 ANLN CAPZA2 YWHAQ MAP3K21	2.24e-05	143	80	6	int:PHLDB2
Interaction	CGN interactions	MAPKAP1 ANLN CAPZA2 YWHAQ MAP3K21 RPA2	3.16e-05	152	80	6	int:CGN
Interaction	CALM1 interactions	TPP2 KIF23 NEUROD1 WFS1 ANLN DISC1 SCN5A BAG1 YWHAQ GLP2R AGAP3	3.57e-05	626	80	11	int:CALM1
Interaction	TJP1 interactions	KIAA1671 KIF23 WFS1 ANLN CLDN16 PLEC YWHAQ RPA2	4.44e-05	325	80	8	int:TJP1
Interaction	RTTN interactions	KIF23 ANLN RPA2	5.58e-05	19	80	3	int:RTTN
Interaction	MACF1 interactions	KIF23 ANLN DISC1 CAPZA2 PLEC YWHAQ RPA2	5.66e-05	247	80	7	int:MACF1
Cytoband	8q24.1	ENPP2 CCN3	6.58e-05	7	82	2	8q24.1
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SSC4D CD163L1 CD163	9.60e-05	27	60	3	1253
GeneFamily	Clustered protocadherins	PCDHA7 PCDHA4 PCDHA3	1.25e-03	64	60	3	20
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K21 MAP3K4	2.85e-03	24	60	2	654
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN RP1 CMYA5	7.87e-07	172	82	6	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN RP1 CMYA5	7.87e-07	172	82	6	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	OGFRL1 RBM44 CLEC4A ENPP2 PRR14L CD163	8.14e-07	173	82	6	8384d533a1071fc65a06e6d9f5f17d8ab00c3966
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A ADIG BAG1 CLDN16 UMOD PERM1	1.13e-06	183	82	6	6b5fa169477821355d1ab7aa11935cdfde1c339c
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN RP1 CMYA5	1.36e-06	189	82	6	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN RP1 CMYA5	1.36e-06	189	82	6	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A KIF23 MALRD1 UMOD RP1	1.95e-05	178	82	5	4df6218b20c2f076c22346d23260964cc0d73e65
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.06e-05	180	82	5	eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.06e-05	180	82	5	a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCell	15-Airway-Epithelial-Submucosal_gland\|Airway / Age, Tissue, Lineage and Cell class	OGFRL1 ANO9 MFSD6L DMBT1 RNF39	2.06e-05	180	82	5	283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	KIF23 ANLN CD163L1 ENPP2 CD163	2.06e-05	180	82	5	4eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.23e-05	183	82	5	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A ADIG BAG1 CLDN16 UMOD	2.23e-05	183	82	5	03c7e69136d5a3b9c5b2c91733e9b1c791f45c49
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.29e-05	184	82	5	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-Cycling_Dendritic\|lymph-node_spleen / Manually curated celltypes from each tissue	KIF23 CLEC4A ANLN RNF39 PPM1J	2.35e-05	185	82	5	912d8efdc37820dbb07736221a98af929e5a7c97
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.41e-05	186	82	5	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.41e-05	186	82	5	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.48e-05	187	82	5	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.48e-05	187	82	5	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.48e-05	187	82	5	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.48e-05	187	82	5	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF462 RHBDF1 TOPBP1 PRR14L CMYA5	2.48e-05	187	82	5	a6a112689d1c9049f57935ad9d2f4955538427de
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.48e-05	187	82	5	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.54e-05	188	82	5	4db566f3f708e66730aa9e16f4d73d91dc534177
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.54e-05	188	82	5	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.54e-05	188	82	5	6704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.60e-05	189	82	5	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.67e-05	190	82	5	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.67e-05	190	82	5	cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.74e-05	191	82	5	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.74e-05	191	82	5	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	2.74e-05	191	82	5	715f5b449b8e075959c05a5b38389df319663164
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 CLDN16 UMOD RP1	2.81e-05	192	82	5	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	3.10e-05	196	82	5	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A SCN5A PERM1 CORIN CMYA5	3.10e-05	196	82	5	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac-Erythrophagocytic_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	CLEC4A CD163L1 ENPP2 GNB4 CD163	3.18e-05	197	82	5	be9879e3352b8c17e91ab1e2d1fb4c30ef6d8ce8
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD163L1 DISC1 GNB4 CD163 AGAP3	3.18e-05	197	82	5	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD163L1 DISC1 GNB4 CD163 AGAP3	3.18e-05	197	82	5	304044ace926943b8eb588f686ecbe5d1689a809
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / Treatment groups by lineage, cell group, cell type	KIF23 ANLN DISC1 RP1 RPA2	3.18e-05	197	82	5	038fd92750257d43d5e980fd06d77742b543f11a
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac\|GI_small-bowel / Manually curated celltypes from each tissue	CLEC4A CD163L1 ENPP2 GNB4 CD163	3.25e-05	198	82	5	748db69d3c9774e44c0cc425d937d18b83af8312
ToppCell	Transverse-Dendritic_cell-cycling_DCs\|Transverse / Region, Cell class and subclass	KIF23 CLEC4A ANLN GNB4 CD163	3.41e-05	200	82	5	f588d8889f351c797963616a3575fa43efd46b9a
ToppCell	Sigmoid-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	KIF23 ANLN CD163L1 CD163 AGAP3	3.41e-05	200	82	5	372fe9018481a4e9ac6ab3af43705a48238c4376
ToppCell	Transverse-(5)_Dendritic_cell-(52)_cycling_DCs\|Transverse / shred on region, Cell_type, and subtype	KIF23 CLEC4A ANLN GNB4 CD163	3.41e-05	200	82	5	51e643d48b5e97a0e117b578a6ea7d429c6cdd1e
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	KIF23 ANLN POLA1 TOPBP1 YWHAQ	3.41e-05	200	82	5	7e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	KIF23 ANLN POLA1 TOPBP1 YWHAQ	3.41e-05	200	82	5	9775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	VWA3A NEUROD1 WFS1 GLP2R	7.17e-05	120	82	4	a6d0406a174d46ce06b41280292931954af88a59
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Ptrf\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEUROD1 WFS1 DISC1 CD163	1.07e-04	133	82	4	a1bc34e5dda4ff4716b857931cc196f6770f58f4
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEUROD1 WFS1 ENPP2 CD163	1.61e-04	148	82	4	d5cace5605bff2bb8248fadb51f2dad7539930ba
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWA3A KIF23 RHBDF1 ANLN	1.74e-04	151	82	4	c06a54afe918b14f885d6a85fbcf81e80f33afae
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Agmat\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEUROD1 WFS1 ENPP2 DISC1	1.97e-04	156	82	4	09e0702400570089d9012dcf94dfb4827c97e49d
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	VWA3A NEUROD1 WFS1 ENPP2	1.97e-04	156	82	4	2cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPARGC1A KIF23 LSG1 ZNF570	2.02e-04	157	82	4	bd45590da540a557dc8096980a45220fccb99505
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OGFRL1 RBM44 POLA1 WDR12	2.02e-04	157	82	4	eea53cf8d8a607264e1ee00b7a97c94bcf2ac80d
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPARGC1A KIF23 LSG1 ZNF570	2.02e-04	157	82	4	00c9a58b033b8b95b0d838f233dd077b62d8b02a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 UMOD RP1	2.17e-04	160	82	4	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A CLDN16 UMOD RP1	2.33e-04	163	82	4	cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYO15B CORIN RP1	2.35e-04	65	82	3	25d2f56f6cd982a227772f8a3b453cdcc8516a47
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYO15B CORIN RP1	2.35e-04	65	82	3	d7d571be0662967e6d8d934e45f928a2f9e1c06a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	VWA3A ADAMTSL1 CLDN16 RP1	2.44e-04	165	82	4	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	VWA3A ADAMTSL1 CLDN16 RP1	2.44e-04	165	82	4	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A9 ASXL1 ADAMTSL1 ANKRD30A	2.44e-04	165	82	4	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	LPS-antiTNF-Endothelial-Mes-Like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1671 PPARGC1A ANLN CARS1	2.50e-04	166	82	4	3b750d4023a0a09d86113aae5a97d84391f7b482
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	KIAA1671 ANLN ANKRD24 DMBT1	2.50e-04	166	82	4	d16af6570806ed2880bd0efb5298932fd2a89cf5
ToppCell	E16.5-Endothelial-Endothelial_lymphatic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN5A APBA2 PLEC SIPA1	2.56e-04	167	82	4	b93103a868fba63a8910bffb690a6242b9252833
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN5A APBA2 PLEC SIPA1	2.56e-04	167	82	4	fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN5A APBA2 PLEC SIPA1	2.56e-04	167	82	4	f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN5A APBA2 PLEC SIPA1	2.56e-04	167	82	4	26cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF671 ENPP2 TOPBP1 ZMYM3	2.67e-04	169	82	4	c8691c4f707d46b2865fe46eabe24ea4d03c7b43
ToppCell	facs-Marrow-T_cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DISC1 APBA2 ANKRD24 CD163	2.67e-04	169	82	4	2a35846b0e0be0a19a5a04a86cbd72ce65257c8a
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN16 UMOD PERM1 MFSD6L	2.86e-04	172	82	4	87a30a219b0a6979abb5fba292a2d8ea946fd849
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN16 UMOD PERM1 MFSD6L	2.86e-04	172	82	4	5030ac31709cac236bb58f4ef9d545d24690411a
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KIF23 POLA1 MDM1 MFSD6L	2.86e-04	172	82	4	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	PPARGC1A ATF7IP2 RP1 AGTPBP1	2.99e-04	174	82	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 UMOD RP1	3.05e-04	175	82	4	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SCN5A APBA2 RNF39	3.12e-04	176	82	4	057d2759fdc67176c25802b57a78064d8cc93205
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SCN5A APBA2 RNF39	3.12e-04	176	82	4	b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	OGFRL1 ANLN WDR12 GNB4	3.12e-04	176	82	4	4bba41ebf9dd187c8705a6997ed039878de62b4e
ToppCell	facs-Spleen-nan-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1671 CD163L1 PPM1J RPA2	3.19e-04	177	82	4	0d894a14ddbb2734557743e9efdb89cee5c26769
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	POLA1 CD40 MAP3K21 ZMYM3	3.19e-04	177	82	4	95760841b3f085d38c4926b258a33563d93a2016
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1671 ZNF462 CD163L1 PERM1	3.26e-04	178	82	4	408e41c853f608965cef9111fb87fdc311cdc7a8
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OGFRL1 CLEC4A CD163L1 CD163	3.33e-04	179	82	4	409364d916c5e7e2291284cc74351d8f8a8447ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A ASXL1 ADAMTSL1 ANKRD30A	3.40e-04	180	82	4	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 UMOD RP1	3.40e-04	180	82	4	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A BAG1 CLDN16 UMOD	3.40e-04	180	82	4	0b653b1b653b40f3b8711d1312029a4a8a4961db
ToppCell	NS-critical-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZNF462 PPARGC1A WFS1 MFSD6L	3.47e-04	181	82	4	cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OGFRL1 ANO9 PLEC PPM1J	3.54e-04	182	82	4	b4f347fb684f6840c166d7473f3f56389f69c14b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 UMOD RP1	3.54e-04	182	82	4	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-CD163+CD14+_DCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	OGFRL1 CLEC4A ENPP2 CD40	3.69e-04	184	82	4	2dc4b2a9970111ed5e2977fc178595a12d7bb59d
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	PPARGC1A WFS1 ATF7IP2 RP1	3.69e-04	184	82	4	561592edc3083fad41b91811151b442207c65dd9
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	CD163L1 ENPP2 DISC1 CD163	3.77e-04	185	82	4	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 CD163L1 SCN5A APBA2	3.77e-04	185	82	4	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CD163L1 ENPP2 DISC1 CD163	3.77e-04	185	82	4	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 UMOD RP1	3.77e-04	185	82	4	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	KIF23 MALRD1 ANLN DMBT1	3.85e-04	186	82	4	189b75aa98903f1cb65b624524ba6c30df7e42ff
ToppCell	356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|356C / Donor, Lineage, Cell class and subclass (all cells)	KIF23 MALRD1 ANLN DMBT1	3.85e-04	186	82	4	261891d0b148e285339ae0b9e36136ceabd9b6f5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 UMOD RP1	3.92e-04	187	82	4	85e58a312fc325e4063a2d250666b99b8f99beb6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPARGC1A MALRD1 UMOD RP1	3.92e-04	187	82	4	52b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A CORIN RP1 CMYA5	4.00e-04	188	82	4	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A CORIN RP1 CMYA5	4.00e-04	188	82	4	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPARGC1A CORIN RP1 CMYA5	4.00e-04	188	82	4	0554d542149cef654ff1e5e32dfbffd8990b52bd
Disease	protein nov homolog measurement	ENPP2 CCN3	4.34e-05	4	80	2	EFO_0020685
Disease	resting heart rate	MAPKAP1 PPARGC1A SCN5A CAPZA2 PLEC	5.44e-05	149	80	5	EFO_0004351
Disease	1,5 anhydroglucitol measurement	PCDHA7 PCDHA4 PCDHA3	6.66e-05	29	80	3	EFO_0008009
Disease	kallikrein-7 measurement	CD163L1 CD163	7.22e-05	5	80	2	EFO_0008195
Disease	age related macular degeneration (implicated_via_orthology)	PPARGC1A MDM1	1.08e-04	6	80	2	DOID:10871 (implicated_via_orthology)
Disease	colitis (implicated_via_orthology)	PPARGC1A CD40	5.55e-04	13	80	2	DOID:0060180 (implicated_via_orthology)
Disease	Autosomal recessive limb-girdle muscular dystrophy	POMGNT1 PLEC	6.47e-04	14	80	2	cv:C2931907
Disease	respiratory symptom change measurement, response to placebo	PPARGC1A ATF7IP2	9.61e-04	17	80	2	EFO_0008344, EFO_0010068
Disease	post-traumatic stress disorder symptom measurement	PCDHA7 PCDHA4 PCDHA3	1.46e-03	82	80	3	EFO_0008535
Disease	pulse pressure measurement, alcohol consumption measurement	ENPP2 CCN3	1.62e-03	22	80	2	EFO_0005763, EFO_0007878
Disease	visceral adipose tissue measurement, body mass index	PCDHA7 PCDHA4 PCDHA3	1.73e-03	87	80	3	EFO_0004340, EFO_0004765
Disease	chronic widespread pain	WDR70 CDON	1.77e-03	23	80	2	EFO_0010099
Disease	smoking cessation	MAPKAP1 ASXL1 ENPP2 CCN3 RBX1	1.92e-03	325	80	5	EFO_0004319
Disease	Alzheimer disease	DISC1 WDR70 WDR12 PLEC YWHAQ CDON	2.06e-03	485	80	6	MONDO_0004975
Disease	L lactate dehydrogenase measurement	CD163L1 CD163	2.26e-03	26	80	2	EFO_0004808
Disease	Endogenous Hyperinsulinism	CD40 CD163	2.26e-03	26	80	2	C1257963
Disease	Exogenous Hyperinsulinism	CD40 CD163	2.26e-03	26	80	2	C1257964
Disease	Compensatory Hyperinsulinemia	CD40 CD163	2.26e-03	26	80	2	C1257965
Disease	Limb-girdle muscular dystrophy	POMGNT1 PLEC	2.26e-03	26	80	2	cv:C0686353
Disease	Abnormality of refraction	ZNF462 PPARGC1A ADAMTSL1 PCDHA7 PCDHA4 PCDHA3 RBX1	2.34e-03	673	80	7	HP_0000539
Disease	TYPE 2 DIABETES MELLITUS	NEUROD1 WFS1	2.62e-03	28	80	2	125853
Disease	Type 2 diabetes mellitus	NEUROD1 WFS1	2.62e-03	28	80	2	cv:C0011860
Disease	Hyperinsulinism	CD40 CD163	2.62e-03	28	80	2	C0020459

Protein segments in the cluster

Peptide	Gene	Start	Entry
SCSVSSADQWSEATT	AGAP3	496	Q96P47
TLWTSDSAGEECDAA	YWHAQ	226	P27348
EENSWDSESPCETVS	ANKRD30B	571	Q9BXX2
QDSEENDSSVCLDWE	ADIG	41	Q0VDE8
SWADSQTSSCLCADD	A2ML1	836	A8K2U0
EENSWDTESLCETVS	ANKRD30A	681	Q9BXX3
ESSWDSESLCETVSQ	ANKRD30A	801	Q9BXX3
TDCWMVNADDSLEVS	CLDN16	26	Q9Y5I7
EEATWSEEATQSEEA	BAG1	96	Q99933
TDECQEAVEEWTDSA	APBA2	131	Q99767
MEISTCETEASEQWD	ANO9	21	A1A5B4
QASCVVDVVDSSGWT	ANKRD24	136	Q8TF21
TVCDDGWNTTASTVV	CD163L1	71	Q9NR16
VWHTNDNATSCDVVE	AGTPBP1	1036	Q9UPW5
DSSETLDASWEAACS	DISC1	151	Q9NRI5
RTECESGTTSWESDD	ASXL1	786	Q8IXJ9
ASATSEECTVAWGVC	RBX1	61	P62877
DCQTSWTSVFDDSII	RBM44	376	Q6ZP01
ETESSFAMTCWDNES	MEIOB	201	Q8N635
WATASVSVEVADVND	PCDHA7	436	Q9UN72
VEDCDSTWQTDSEPE	OGFRL1	16	Q5TC84
WATASVSVEVADVND	PCDHA3	436	Q9Y5H8
VSDQDCSTATSLEWA	LINS1	36	Q8NG48
WTEQCQSGESLATES	KIAA1671	1541	Q9BY89
DCSQDWKESSTADSE	LSG1	331	Q9H089
AATICSWEDDVNHSF	ANLN	206	Q9NQW6
SWEAQDSAERNTTSE	ADAMTSL1	1041	Q8N6G6
VSDTSDSEQGTEQDW	MFSD6L	561	Q8IWD5
DSNCCWDVSSTTSSE	MDM1	366	Q8TC05
SGDTTCALWDIETAQ	GNB4	161	Q9HAV0
CWDIDQEGDSSFSVQ	POLA1	306	P09884
CNQDSESVWSDIECA	PPARGC1A	6	Q9UBK2
SSDWQGQICSSTDSD	PPARGC1A	416	Q9UBK2
SEECYSAEVESWTTG	MYO15B	656	Q96JP2
WATASVSVEVADVND	PCDHA4	436	Q9UN74
GNWTTACSLTQDSED	MALRD1	1736	Q5VYJ5
ACSLTQDSEDDLDWA	MALRD1	1741	Q5VYJ5
IENATDIWQDDSECS	GLP2R	146	O95838
TFSAVGEASICEDDW	IGHM	281	P01871
DSSVNCIEQTTEWTA	CCN3	201	P48745
WASEESQTSGVCSRE	CMYA5	96	Q8N3K9
VWEGDSCAHSETEIN	CDON	1231	Q4KMG0
SDSSDEWDCVTLSIN	CORIN	681	Q9Y5Q5
NCESADSTWQSSLDT	ATF7IP2	261	Q5U623
GTVCDDSWDLDDAQV	CD163	951	Q86VB7
VCDDSWDTNDANVVC	DMBT1	126	Q9UGM3
TVCDDSWDTSDANVV	DMBT1	386	Q9UGM3
GTVCDDSWDTNDANV	DMBT1	516	Q9UGM3
VCDDSWDTNDANVVC	DMBT1	626	Q9UGM3
TVCDDSWDTNDANVV	DMBT1	756	Q9UGM3
VCDDSWDTSDANVVC	DMBT1	886	Q9UGM3
TVCDDSWDTNDANVV	DMBT1	1016	Q9UGM3
DDVECSGTESTLWQC	DMBT1	1951	Q9UGM3
TATSWSEADTEPCVD	SLC22A11	101	Q9NSA0
SDQDWAEFSATADEC	PERM1	11	Q5SV97
DNEESCNSSEDESKW	ENPP2	801	Q13822
WSNSSDRDSVCTCVE	PRR14L	1291	Q5THK1
GAESEWTDVETRCSV	KIF23	921	Q02241
VAETCSSASWENATV	RP1	416	P56715
QESCAEFWTSADDSS	MAP3K4	771	Q9Y6R4
QSIDKSEASADTWCS	UTY	306	O14607
DWLDSTLGCDVTDNS	CARS1	196	P49589
AESWEEAASANAATV	MAP3K21	686	Q5TCX8
SFSSTIVTEWDLVCD	SLC22A9	126	Q8IVM8
LSSAEEAECHWADTE	POMGNT1	246	Q8WZA1
VQTSEEECSSTLAVW	RHBDF1	511	Q96CC6
WDVTTDCEVAATVDR	PPM1J	431	Q5JR12
TASSEAEASASQADW	SCN5A	1101	Q14524
DLDSTLESQSAWEFC	MAPKAP1	336	Q9BPZ7
EDEWQAISEIASTCN	SIPA1	926	Q96FS4
ENEDLWAESEGTVAC	PEX13	206	Q92968
CEVENAVESWRTSVE	CAPZA2	111	P47755
STESASWQDSEKDCA	CLEC4A	121	Q9UMR7
AVSSSVASTDWQDID	TEX44	36	Q53QW1
CWHGVEDEEVSSEQS	ZNF671	131	Q8TAW3
QWVDTDDTSSENTVV	RPA2	106	P15927
TAATDTSEARWCSEC	UMOD	21	P07911
SVCDDDWDVVDANVV	SSC4D	81	Q8WTU2
TCSNDATVRTWEVEN	WDR70	301	Q9NW82
TWAEVTVCSCSSEVS	TPP2	671	P29144
QECEWEEITISSSDG	PLEC	4311	Q15149
VDFSQEEWDCLDSSQ	ZNF570	21	Q96NI8
CQVWTGESSQVSEDE	ZNF233	141	A6NK53
TSDWDAVNSQSESIS	ZNF462	496	Q96JM2
SSVLWSDAEEICSAS	WDR12	261	Q9GZL7
SDAEEICSASWDHTI	WDR12	266	Q9GZL7
CEVEATVGEVVTNTW	TOPBP1	601	Q92547
TEQLDGSTWDFCSED	ZMYM3	691	Q14202
TSETDTICTCEEGWH	CD40	96	P25942
QSWQDTLVETTDAAC	VWA3A	1006	A6NCI4
WEVETADAASCRDSS	RNF39	286	Q9H2S5
DTDEELNSCTAVDWL	WFS1	116	O76024
SWTDECLSSQDEEHE	NEUROD1	21	Q13562