Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

8.68e-051412289GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

1.12e-041459289GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZIC1

1.33e-031244287GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZIC1

1.51e-031271287GO:0000987
Domainzf-C2H2

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

6.51e-07693299PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

6.58e-07694299IPR013087
DomainZINC_FINGER_C2H2_2

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

1.65e-06775299PS50157
DomainZINC_FINGER_C2H2_1

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

1.69e-06777299PS00028
DomainZnf_C2H2-like

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

2.06e-06796299IPR015880
DomainZnf_C2H2

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

2.26e-06805299IPR007087
DomainZnF_C2H2

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

2.33e-06808299SM00355
Domain-

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1

6.38e-066792983.30.160.60
Domainzf-C2H2_6

ZNF578 ZNF676 ZNF91 ZNF714 ZNF891

1.11e-04314295PF13912
DomainKRAB

ZNF578 ZNF676 ZNF91 ZNF714 ZNF891

2.05e-04358295PS50805
DomainKRAB

ZNF578 ZNF676 ZNF91 ZNF714 ZNF891

2.35e-04369295SM00349
DomainKRAB

ZNF578 ZNF676 ZNF91 ZNF714 ZNF891

2.38e-04370295IPR001909
DomainPROTEIN_KINASE_ATP

TNNI3K ROS1 CAMKK2 MAP3K8

5.25e-03459294PS00107
DomainProt_kinase_dom

TNNI3K ROS1 CAMKK2 MAP3K8

6.56e-03489294IPR000719
DomainPROTEIN_KINASE_DOM

TNNI3K ROS1 CAMKK2 MAP3K8

6.75e-03493294PS50011
DomainG-protein_beta_WD-40_rep

PAK1IP1 WDR17

7.67e-0385292IPR020472
DomainKinase-like_dom

TNNI3K ROS1 CAMKK2 MAP3K8

9.37e-03542294IPR011009
Pubmed

Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient.

ZIC4 ZIC1

6.71e-07229221204220
Pubmed

Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.

ZIC4 ZIC1

6.71e-07229235997131
Pubmed

Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.

ZIC4 ZIC1

2.01e-06329215338008
Pubmed

Transcriptional expression of ZICs as an independent indicator of survival in gliomas.

ZIC4 ZIC1

2.01e-06329234475426
Pubmed

The ZIC gene family in development and disease.

ZIC4 ZIC1

2.01e-06329215733262
Pubmed

High-depth spatial transcriptome analysis by photo-isolation chemistry.

ZIC4 ZIC1

4.02e-06429234285220
Pubmed

Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.

ZIC4 ZIC1

4.02e-06429215895369
Pubmed

If the skull fits: magnetic resonance imaging and microcomputed tomography for combined analysis of brain and skull phenotypes in the mouse.

ZIC4 ZIC1

4.02e-06429222947655
Pubmed

Increased enhancer-promoter interactions during developmental enhancer activation in mammals.

ZIC4 ZIC1

1.00e-05629238509385
Pubmed

Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.

ZIC4 ZIC1

1.00e-05629215465018
Pubmed

Fine mapping of the circling (cir) gene on the distal portion of mouse chromosome 9.

ZIC4 ZIC1

1.41e-05729214727813
Pubmed

The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes.

ZIC4 ZIC1

2.41e-05929225178196
Pubmed

Spatiotemporal expression of Zic genes during vertebrate inner ear development.

ZIC4 ZIC1

3.01e-051029223606270
Pubmed

CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.

ZIC4 ZIC1

3.01e-051029218298960
Pubmed

FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development.

ZIC4 ZIC1

3.68e-051129218547559
Pubmed

The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.

ROS1 MAP3K8

6.07e-05142929151674
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ANKRD17 DEPDC1 ZNF148 RCBTB1 MAP3K8 LACTB

6.43e-0585729625609649
Pubmed

Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.

ZIC4 ZIC1

9.06e-051729226025376
Pubmed

Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.

ZIC4 ZIC1

1.99e-042529215229182
Pubmed

Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.

ZIC4 ZIC1

1.99e-042529221307096
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

TNNI3K CAMKK2 RCBTB1 MAP3K8

2.48e-0437229422939624
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

EEFSEC ANKRD17 ROS1 PAK1IP1 GPC3 LACTB

8.08e-04137129636244648
Cytoband19p12

ZNF676 ZNF91 ZNF714

2.57e-059029319p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF676 ZNF91 ZNF714

6.36e-05122293chr19p12
Cytoband3q24

ZIC4 ZIC1

1.77e-04312923q24
CytobandEnsembl 112 genes in cytogenetic band chr3q24

ZIC4 ZIC1

4.09e-0447292chr3q24
CytobandEnsembl 112 genes in cytogenetic band chr3q21

EEFSEC ZNF148

4.61e-03160292chr3q21
CytobandEnsembl 112 genes in cytogenetic band chr1p31

TNNI3K DEPDC1

8.82e-03224292chr1p31
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZIC4 ZNF578 ZNF676 ZNF148 ZNF91 ZNF714 ZNF891 ZIC1 ZNF518A

1.16e-0771823928
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-Cortical_hem|1_mon / Sample Type, Dataset, Time_group, and Cell type.

ZIC4 GPC3 MAP3K8 ZIC1

7.32e-061942946f32422e1c079a2fbf0ab568e6cb8365fd627d9a
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Proliferating|6_mon / Sample Type, Dataset, Time_group, and Cell type.

ZIC4 DEPDC1 GPC3 ZIC1

8.25e-06200294c784459a62bebec560e79aba83de8611457437bc
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Proliferating-Cycling|6_mon / Sample Type, Dataset, Time_group, and Cell type.

ZIC4 DEPDC1 GPC3 ZIC1

8.25e-06200294322337a5a9cc2de1913ee9258c98ae51fb4bd6bb
DiseaseDandy-Walker syndrome (implicated_via_orthology)

ZIC4 ZIC1

2.80e-063292DOID:2785 (implicated_via_orthology)
Diseaselevel of Sphingomyelin (d34:2) in blood serum

ANKRD17 SGPL1

7.23e-0513292OBA_2045174
DiseaseAdenocarcinoma of large intestine

TNNI3K ROS1 CAMKK2

1.15e-0496293C1319315
Diseaseage at first sexual intercourse measurement

ZIC4 TNNI3K ZIC1 ZNF518A

5.13e-04383294EFO_0009749
Diseasenicotine dependence symptom count

ZIC4 TNNI3K SGPL1

2.71e-03285293EFO_0009262
DiseaseVertigo

ZNF148 ZNF91

8.23e-03139292HP_0002321
DiseaseLiver carcinoma

ZIC4 DEPDC1 GPC3

1.32e-02507293C2239176
Diseaseprostate specific antigen measurement

EEFSEC GPC3

1.46e-02188292EFO_0004624

Protein segments in the cluster

PeptideGeneStartEntry
GGHVKIVKLLLAHKA

ANKRD17

311

O75179
IDGKYIHVHKAVLKI

RCBTB1

376

Q8NDN9
LFIDKKVLKVAHVEH

GPC3

366

P51654
HLSGIRHYEKDIKKV

LACTB

216

P83111
HVLKGLDFLHSKKVI

MAP3K8

236

P41279
NKLIHIKKYGEHNVL

MUC19

561

Q7Z5P9
TAVEKHLDYLKKGHI

DEPDC1

691

Q5TB30
LIKGIEYLHYQKIIH

CAMKK2

296

Q96RR4
AEVYHHLKGVIKAKY

ENO3

186

P13929
VHKDSGLYKELLHKL

SLC20A1

381

Q8WUM9
GLYKELLHKLHLAKV

SLC20A1

386

Q8WUM9
TKEILHKYKLHGKRI

PPEF1

246

O14829
KVTRYIHHKIVGKLH

TDRD12

1016

Q587J7
IIRTIDGKVLHKYKH

WDR17

506

Q8IZU2
VAKLAVKYKIPLHVD

SGPL1

301

O95470
RLKVYKLKHKHGLVE

EEFSEC

466

P57772
LTKHKIIHTGEKLYK

ZNF714

411

Q96N38
ILTKHKIIHTGEKRY

ZNF676

491

Q8N7Q3
VRKHQIIHLGEKQYK

ZNF578

246

Q96N58
YPHTKKIKIKAIIIH

TMPRSS12

146

Q86WS5
LEHKVKYPREVKIHN

ROS1

1256

P08922
VITLHKEHLYAKEKL

ZNF518A

281

Q6AHZ1
GASKHKLHYRKEVEI

PKD2L2

11

Q9NZM6
IYDMKKKIEHGALVH

PAK1IP1

66

Q9NWT1
KAKYKLVNHIRVHTG

ZIC4

186

Q8N9L1
LTTHKIIHAGKKLYK

ZNF91

561

Q05481
LTKHKIIHAGEKLYK

ZNF91

701

Q05481
LAKHKIIHAGEKLYK

ZNF91

841

Q05481
KYKLVNHIRVHTGEK

ZIC1

286

Q15915
KYLLQRHEKIHTGEK

ZNF148

211

Q9UQR1
EKGHDAIVTLLKHYK

TNNI3K

391

Q59H18
HLKVHKKIHTGENVY

ZNF891

446

A8MT65