Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscellular response to dopamine

PRKN RGS9 DRD5 ALK

9.50e-0664434GO:1903351
GeneOntologyBiologicalProcessresponse to dopamine

PRKN RGS9 DRD5 ALK

1.07e-0566434GO:1903350
GeneOntologyBiologicalProcesscellular response to monoamine stimulus

PRKN RGS9 DRD5 ALK

1.21e-0568434GO:0071868
GeneOntologyBiologicalProcesscellular response to catecholamine stimulus

PRKN RGS9 DRD5 ALK

1.21e-0568434GO:0071870
GeneOntologyBiologicalProcessresponse to catecholamine

PRKN RGS9 DRD5 ALK

1.61e-0573434GO:0071869
GeneOntologyBiologicalProcessresponse to monoamine

PRKN RGS9 DRD5 ALK

1.69e-0574434GO:0071867
GeneOntologyBiologicalProcesspositive regulation of molecular function

EPHB2 NEDD9 PRKN RGS9 ACTN2 DRD5 TNFSF18 EIF2AK3 ALK ODAM SIRT3 TP53BP1

2.40e-0514304312GO:0044093
GeneOntologyBiologicalProcessG protein-coupled dopamine receptor signaling pathway

RGS9 DRD5 ALK

1.05e-0444433GO:0007212
GeneOntologyBiologicalProcesslearning or memory

EPHB2 NEDD9 PRKN MME DRD5 GRM4

1.16e-04373436GO:0007611
GeneOntologyBiologicalProcesscognition

EPHB2 NEDD9 PRKN MME DRD5 GRM4

2.30e-04423436GO:0050890
GeneOntologyBiologicalProcesscellular response to manganese ion

PRKN EIF2AK3

2.77e-0412432GO:0071287
Pubmed

EphB2 signaling-mediated Sirt3 expression reduces MSC senescence by maintaining mitochondrial ROS homeostasis.

EPHB2 SIRT3

1.56e-06244228687409
Pubmed

Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway.

VRK1 TP53BP1

1.56e-06244231629252
Pubmed

Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function.

EPHB2 MYCBP2

1.56e-06244238289221
Pubmed

Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.

VRK1 TP53BP1

4.69e-06344222621922
Pubmed

Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy.

PRKN SIRT3

4.69e-06344227794418
Pubmed

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase.

VRK1 TP53BP1

4.69e-06344231101118
Pubmed

Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair.

SIRT3 TP53BP1

4.69e-06344229136592
Pubmed

Brain-specific regulator of G-protein signaling 9-2 selectively interacts with alpha-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors.

RGS9 ACTN2

9.37e-06444216510730
Pubmed

Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.

PRKN SIRT3

1.56e-05544229674007
Pubmed

Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress.

PRKN EIF2AK3

1.56e-05544216720581
Pubmed

Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

EPHB2 NEDD9 RBM5

7.11e-056344310508479
Pubmed

DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4.

PRKN UPF1

1.21e-041344235659652
Pubmed

The reduction of oocytes and disruption of the meiotic prophase I in Fanconi anemia E-deficient mice.

DAZL TP53BP1

1.21e-041344235671285
Pubmed

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.

MYCBP2 ALK

2.10e-041744219398581
Pubmed

Genome-wide Analysis of RARβ Transcriptional Targets in Mouse Striatum Links Retinoic Acid Signaling with Huntington's Disease and Other Neurodegenerative Disorders.

RGS9 ACTN2

2.36e-041844227405468
Pubmed

The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.

TRBV5-7 TRBV5-6 TRBV5-5

2.41e-04954438650574
Pubmed

ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.

ACTN2 FOXC2

2.64e-041944235177595
Pubmed

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.

ASF1B PARP2

2.64e-041944220504901
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

RBM5 CCDC97 PARP2 TP53BP1

2.87e-0425144431076518
Pubmed

Characterization of a common progenitor pool of the epicardium and myocardium.

ACTN2 FOXC2

3.24e-042144233414188
Pubmed

Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.

PRKN ACTN2

4.24e-042444225348719
Pubmed

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.

RGS9 DRD5 GRM4

4.56e-0411844319156168
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

CHSY3 VRK1 EIF2AK3 PARP2 TP53BP1 FOXC2

6.99e-0485744625609649
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

EPHB2 CFH CHSY3 MYCBP2 EIF2AK3 GLCE SEL1L3

7.21e-04120144735696571
Pubmed

The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.

ACTN2 FOXC2

7.57e-043244223369715
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

EPHB2 ALK

1.18e-034044230898150
InteractionRGS9 interactions

PRKN RGS9 ACTN2

6.87e-0619403int:RGS9
InteractionGRIN1 interactions

EPHB2 PRKN RGS9 ACTN2 TP53BP1

1.29e-05154405int:GRIN1
InteractionLRCH2 interactions

BPNT1 PRKN MYCBP2 TP53BP1

1.31e-0573404int:LRCH2
Cytoband7q34

TRBV5-7 TRBV5-6 TRBV5-5

6.00e-041674537q34
CytobandEnsembl 112 genes in cytogenetic band chr7q34

TRBV5-7 TRBV5-6 TRBV5-5

8.07e-04185453chr7q34
GeneFamilyT cell receptor beta locus at 7q34

TRBV5-7 TRBV5-6 TRBV5-5

4.83e-0487323372
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAZL RGS9 MME ACTN2 GRM4

1.10e-06182455d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAZL RGS9 MME ACTN2 GRM4

1.10e-061824556cde859edfe7607bd7ada89d20258413d06f4207
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-7|TCGA-Liver / Sample_Type by Project: Shred V9

EPHB2 MME ACTN2 ODAM

2.00e-0515945470288df54adab167c0f50675128619299077db11
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DAZL RGS9 ACTN2 OTOF

2.05e-05160454f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DAZL RGS9 ACTN2 OTOF

2.10e-05161454ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 TNFSF18 OTOF MYCBP2

2.15e-0516245493bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHSY3 RGS9 ACTN2 GRM4

2.31e-051654541b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHSY3 RGS9 ACTN2 GRM4

2.31e-05165454b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCelllymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell|World / Lineage, cell class and subclass

CFH CHSY3 RGS9 MYBL1

3.32e-051814540d096d7d557fd2e71b35e41816e11d7e83cd9210
ToppCellmetastatic_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ|metastatic_Lymph_Node / Location, Cell class and cell subclass

BPNT1 MME MYBL1 SEL1L3

3.46e-0518345430db83f600e2c4ad3af68a8a946673f4352a2807
ToppCelllymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell|lymphoid / Lineage, cell class and subclass

CFH CHSY3 RGS9 MYBL1

3.77e-0518745499dfa50f6325b0d66d23ee8dcaa6437e7161628a
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ZFHX2 ITIH3 FOXC2

4.53e-051964547d5eaed189aa6116f3799be010139fb675ec65e0
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH ZFHX2 ITIH3 FOXC2

4.53e-05196454dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCellmLN-B_cell-B_cell_cycling|B_cell / Region, Cell class and subclass

RGS9 MME ASF1B MYBL1

4.62e-051974542071526fe46de8359ea118ff78581eb4454aa55a
ToppCellTracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_alveolar|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NEDD9 MME ACTN2 ITIH3

4.89e-05200454fda92cb28de99a9c4fe83b7db8145a4beafb0826
Diseasecomplement factor H-related protein 2 measurement

CFH SMIM23

8.21e-0429432EFO_0600055

Protein segments in the cluster

PeptideGeneStartEntry
MNQIEPGVQYNYVYD

ACTN2

1

P35609
YQVPPSYQNQGIYQV

NEDD9

106

Q14511
NGALSILQYPYDNGY

EIF2AK3

466

Q9NZJ5
NFYINYYRQQVTGEP

AHSP

46

Q9NZD4
YLNSGPLVYYQVEQR

CSRNP2

411

Q9H175
NENGDAPGRYDIYQY

GRM4

466

Q14833
QGYFYPIQIAQYGLS

GLCE

206

O94923
IQTQCYYQGNIEGYP

ADAM32

91

Q8TC27
FPYLENGYNQNYGRK

CFH

391

P08603
IAGVINQPYYNYEAG

BPNT1

146

O95861
QNLGNFIVRYGYIYP

RGS9

71

O75916
YPGQFALYQQLAQGN

DRD5

11

P21918
ILNPDGYTLNYNEYI

PARP2

546

Q9UGN5
RSLGYAYVNYQQPVD

PABPC1L2A

41

Q5JQF8
APLLYEQYIGQYLTQ

CCDC97

181

Q96F63
QPNGVILDYELQYYE

EPHB2

461

P29323
DNGGLGQAYRAYQNY

MME

651

P08473
QQYEEQIPFYAQFGY

ODAM

171

A1E959
YAAQQYPGNYEQQQI

ACBD3

261

Q9H3P7
NALGVVPYLSEQNYY

FOXC2

11

Q99958
VDYSYLQPGQDGYAQ

RBM5

356

P52756
YEDAYQYQNIFGPLV

UPF1

296

Q92900
FIRVGYYVNNEYLNP

ASF1B

106

Q9NVP2
VQVITGYQLPVYNYQ

DAZL

176

Q92904
QNQFYIPVQIPGYQY

MYBL1

221

P10243
PQLEYYQIYRGNATA

OTOF

1071

Q9HC10
IYAYLQPGNNYSQDQ

OR2B8P

256

P59922
NLGYKHYQGIDNYPL

SEL1L3

611

Q68CR1
ILGEEQYNRYQQYGA

PRKN

306

O60260
PLYNLGFGNNLNYNF

ITIH3

421

Q06033
NYYQNLAVPQGLEYQ

SMIM23

66

A6NLE4
GSGLYSNLQQYDLPY

SIRT3

161

Q9NTG7
LGYAQGYLLYRDVNN

MYCBP2

416

O75592
NVNYGYQQQGLPLEA

ALK

1581

Q9UM73
IQGQQVYYPIIFSQY

CHSY3

736

Q70JA7
QVLGQGPQFIFQYYE

TRBV5-5

56

A0A597
YSYYNQGILPEQGIQ

ZNF519

46

Q8TB69
VFGPQLQGAYFQQLY

ZFHX2

2361

Q9C0A1
QNGLYLIYGQVAPNA

TNFSF18

91

Q9UNG2
QNYRNYLLPAGYSLE

TP53BP1

1841

Q12888
QALGQGPQFIFQYYE

TRBV5-7

56

A0A0A0MS05
QALGQGPQFIFQYYE

TRBV5-6

56

A0A599
NYKNPDQVYLVDYGL

VRK1

186

Q99986
EVYPGQQYLQGGQYA

ZMIZ2

271

Q8NF64
NQIFYKPHEYGQYIG

TMEM117

321

Q9H0C3
PALVYQDYQYLGQQG

THSD8

21

A0A1W2PP97